PMID- 4314900 TI - SV40-specific RNA in the nucleus and polyribosomes of transformed cells. AB - Cells transformed by the oncogenic virus SV40 are known to contain viral DNA integrated into cellular DNA and to produce virus-specific RNA. It has been shown that nuclear molecules containing virus-specific sequences are considerably longer than presumed virus-specific mRNA molecules from cytoplasmic polyribosomes. This finding suggests the possibility that cytoplasmic mRNA is derived by the specific cleavage of larger nuclear RNA. PMID- 4314901 TI - The reductive inactivation of UDPgalactose-4-epimerase from yeast and E. coli. AB - The prosthetic groups of UDPgalactose-4-epimerase from yeast and E. coli can be reduced by incubation with D-galactose or L-arabinose provided that 5' uridylic acid (5'UMP) is also present. This type of concerted reduction can also be performed using sodium borohydride. The latter type of reduction also depends on the addition of 5'UMP. Enzymatic analysis of the released prosthetic group by means of lactic dehydrogenase and pyruvate revealed that the pyridine nucleotide of the reduced epimerase generated in the concerted reaction is dehydrogenated in the 4-position of the pyridine ring. The catalytic activity of the reduced epimerase is much lower than that of epimerase (10-15% of native epimerase). This reductive inactivation was also found in crude epimerase preparations from E. coli, again provided 5'UMP is present. Fractionated E. coli epimerase subjected to the concerted reduction show a striking fluorescent enhancement of the order of magnitude of that observed in the purified yeast epimerase. Unlike the latter, however, E. coli epimerase also becomes fluorescent upon addition of the specific substrate UDPgalactose. The physiological aspects of the phenomenon as related to induction of the galactose genes is discussed. PMID- 4314902 TI - Proteins specified by herpes simplex virus. 3. Viruses differing in their effects on the social behavior of infected cells specify different membrane glycoproteins. AB - We examined the electrophoretic properties of the proteins and glycoproteins in the smooth membranes and virions purified from cells infected with herpes simplex virus strains differing with respect to their effects on the interaction of cells among themselves. The data show the following: (1) The glycoproteins in virions and binding to membranes share common features but vary quantitatively and qualitatively depending on the virus strain. (2) The binding to smooth membranes is ordered and not random. (3) Differences in the glycosylation of membrane proteins in African green monkey (VERO) and human (HEp-2) cells indicate that glycosylation is at least in part determined by the host. PMID- 4314903 TI - Interconversion of phospho- and dephospho- forms of pig heart pyruvate dehydrogenase. AB - Pyruvate dehydrogenase from pig heart exists in active and inactive forms. Interconversion from the active (dephospho) form into the inactive (phospho) form is catalyzed by an ATP-dependent kinase. Conversely the enzyme is reactivated by a phosphatase which removes the phosphate group from the protein. By gradient centrifugation pyruvate dehydrogenase was prepared free of phosphatase but still containing the kinase. Reactivation of pyruvate dehydrogenase is stimulated by adenosine 3',5'-cyclic phosphate. There is incorporation of (32)P from gamma (32)P-ATP into the protein fraction containing the phosphatase and this phosphorylation reaction is also stimulated by adenosine 3',5'-cyclic phosphate. The participation of this phosphate in the pyruvate dehydrogenase interconversion system suggests that, in heart muscle, pyruvate oxidation may be under hormonal control by a mechanism similar to that involved in the regulation of glycogen synthesis and breakdown. PMID- 4314904 TI - Purification and properties of initiation factors F1 and F2. PMID- 4314905 TI - Protein factors involved in polypeptide chain initiation in Escherichia coli. PMID- 4314906 TI - Isolation and some properties of the amino acid polymerization factors from Escherichia coli. PMID- 4314907 TI - Purification and properties of factor G. PMID- 4314908 TI - Protein biosynthesis: studies using synthetic and viral mRNAs. PMID- 4314909 TI - Interaction of guanosine triphosphate with E. coli soluble transfer factors. PMID- 4314910 TI - Peptide chain elongation. PMID- 4314911 TI - Further studies on bacterial polypeptide elongation. PMID- 4314912 TI - Mutants of Escherichia coli blocked in protein synthesis: mutants with an altered G factor. PMID- 4314913 TI - The RNA metabolism of nucleoli and mitochondria in mammalian cells. PMID- 4314914 TI - Inactivation of aminoacyl transferase II by diphtheria toxin. PMID- 4314915 TI - Studies on transferase II using diphtheria toxin. PMID- 4314916 TI - Adenosine diphosphoribosylation of aminoacyl transferase II by diphtheria toxin. PMID- 4314917 TI - A proposed mechanism for ADP ribosylation of aminoacyl transferase II by diphtheria toxin. PMID- 4314918 TI - The 5'-terminus of f2 RNA and the coat protein gene. PMID- 4314919 TI - The formation of poliovirus proteins. PMID- 4314920 TI - Translation of poliovirus RNA by an E. coli cell-free system. PMID- 4314921 TI - Enzymic adenosine diphosphoribosylation of nuclear proteins. PMID- 4314922 TI - Nonribosomal polypeptide synthesis: the biosynthesis of a cyclic peptide antibiotic, gramicidin S. PMID- 4314924 TI - [Luminescent-cytochemical study of the growth of A22 foot-and-mouth disease virus in cell cultures]. PMID- 4314923 TI - Biosynthesis of cyclic oligopeptide. PMID- 4314925 TI - [Survival time of foot-and-mouth disease virus in the sewage of biological products factories]. PMID- 4314926 TI - [Viability of foot-and-mouth disease virus in pastures]. PMID- 4314927 TI - Synaptic organization in the uropile of the lateral eye of Limulus. PMID- 4314928 TI - Isolation from turkeys of a cell-associated herpesvirus antigenically related to Marek's disease virus. PMID- 4314929 TI - Association of stomatitis and paronychias due to herpes simplex. PMID- 4314930 TI - The lipid composition of tissues in Niemann-Pick disease. PMID- 4314932 TI - Metabolism of dibutyryl cyclic adenosine 3',5'-monophosphate during its regulation of lipolysis and glucose oxidation in isolated rat epididymal adipocytes. PMID- 4314933 TI - Purification of rabbit liver fructose 1,6-diphosphatase by substrate elution. PMID- 4314934 TI - Structural analysis of nucleolar precursors of ribosomal ribonucleic acid. Studies on the 5'-terminal and alkali-resistant dinucleotides of nucleolar high molecular weight ribonucleic acid. PMID- 4314935 TI - Structural analysis of nucleolar precursors of ribosomal ribonucleic acid. Comparative hybridizations of nucleolar and ribosomal ribonucleic acid with nucleolar deoxyribonucleic acid. PMID- 4314936 TI - Isolation and purification of a nuclear 4.4 S ribonucleic acid of the Novikoff hepatoma. PMID- 4314937 TI - 17 Beta-estradiol dehydrogenase of ovine ovaries. PMID- 4314938 TI - Studies on the respiratory chain-linked reduced nicotinamide adenine dinucleotide dehydrogenase. XVII. Reaction sites of piericidin A and rotenone. PMID- 4314939 TI - Biosynthesis and characteristics of brain protein and ribonucleic acid in mice subjected to neonatal infection or undernutrition. PMID- 4314940 TI - The prevention of ascending, catheter-induced infections of the urinary tract. PMID- 4314941 TI - Microvascular effects of collagenase. PMID- 4314942 TI - Correlation of collagenase production to periodontal disease. PMID- 4314943 TI - The age change of acid mucopolysaccharides in the periodontal membrane of man. PMID- 4314944 TI - Ultrastructural features of the root surface of deciduous teeth in patients with hypophosphatasia. PMID- 4314945 TI - Undesirable patient behavior: improvement with monetary reward. PMID- 4314947 TI - Do you read the nurses' observation notes? PMID- 4314946 TI - The role of the psychiatric nurse in the rehabilitation of the schizophrenic patient. PMID- 4314948 TI - The mental hospital patient's perception of the aide as a psychotherapist. PMID- 4314949 TI - The developmental concepts of Piaget applied to nursing assessment and interventions with atypical children. PMID- 4314950 TI - Levels of utilization: nursing specialists in community mental health. PMID- 4314951 TI - The psychiatrist-nurse team and home care in Soviet Union and Amsterdam. PMID- 4314953 TI - Free associating on mental health manpower. PMID- 4314952 TI - The First Lady of psychiatric nursing retires (Dr. Esther Garrison). PMID- 4314954 TI - Psychiatric drugs and trends. Drug abuse - the 1969 social concern. II. PMID- 4314955 TI - Programs for culturally deprived and retarded youngsters. An international commentary. PMID- 4314957 TI - The role of the nurse with the drug abuser and addict. PMID- 4314956 TI - Problems in the after care management of the schizophrenic patient. PMID- 4314958 TI - The long road back. PMID- 4314959 TI - The significant others off stage. PMID- 4314960 TI - Behavior modification utilizing a token economy program. PMID- 4314961 TI - Clinical psychology in the mental health service of asocialist community. PMID- 4314962 TI - On standards for psychiatric facilities: philosophically understandable but practically disappointing. PMID- 4314963 TI - Training the nurse in psychiatric group work. PMID- 4314964 TI - Am I my brother's keeper? PMID- 4314965 TI - Who am I? A patient--No. I am. PMID- 4314966 TI - Involvement--a way of nursing. PMID- 4314967 TI - [Reflections on my nursing care]. PMID- 4314968 TI - A method for the determination of dATP and dTTP in picomole amounts. PMID- 4314969 TI - Enzymic degradation of isotopically labeled compounds. I. Degradation of 14C labeled glycerol. PMID- 4314970 TI - Enzymic degradation of isotopically labeded compounds. II. Glucose labeled with 14C and tritium. PMID- 4314971 TI - An evaluation of film detection methods for weak beta-emitters, particularly tritium. PMID- 4314972 TI - Improved ultracentrifuge cells for high-speed sedimentation equilibrium studies with interference optics. PMID- 4314973 TI - A simplified MAK column procedure for separation of RNA subfractions. PMID- 4314974 TI - Variable decomposition by environmental contaminants in air of estrogens on glass plates coated with silica gel for thin-layer chromatography. PMID- 4314975 TI - Biology of the mycobacterioses. Biochemical study on the specificity of the hemagglutination reaction by the phosphatide of the tubercle bacillus. PMID- 4314976 TI - Biology of the mycobacterioses. Structure of mycobacterial phosphatides. PMID- 4314977 TI - Isolation and identification of a new pteridine, neopterinyl-3'-beta-D-glucuronic acid from Bacillus subtilis. PMID- 4314978 TI - Observations on the blood glucose of Lumbricus. PMID- 4314979 TI - [Non-suppressible adrenocortical function in a patient with active acromegaly]. PMID- 4314980 TI - [Successful surgery of primary cancer of the liver]. PMID- 4314981 TI - [Recanalization of the hepatic ducts in their cancerous obstruction]. PMID- 4314982 TI - Calcium pyrophosphate crystal synovitis with articular chondrocalcinosis ("pseudogout" syndrome). PMID- 4314983 TI - [Which diagnosis would you make?]. PMID- 4314984 TI - Temperature and relative humidity requirements of species of Penicillium isolated from yellow dent corn kernels. PMID- 4314985 TI - Melatonin synthesis: adenosine 3',5'-monophosphate and norepinephrine stimulate N acetyltransferase. AB - Treatment of cultured rat pineal glands with norepinephrine or dibutyryl adenosine 3',5'-monophosphate causes a six- to tenfold stimulation of N acetyltransferase. This enzyme converts serotonin to N-acetylserotonin, the immediate precursor of melatonin. The increased synthesis of melatonin caused by norepinephrine treatment appears to be the result of stimulation of N acetyltransferase by an adenosine 3',5'-monophosphate mechanism. PMID- 4314986 TI - Myxovirus antibody increases in human connective tissue disease. AB - Antibodies to measles and parainfluenza type 1 viruses were significantly increased in systemic lupus erythematosus and Reiter's syndrome. Of the individuals with highest titers of measles antibody, 75 percent had neurologic illness. Persistent virus infection may be a factor in the pathogenesis of these diseases. PMID- 4314987 TI - [Epidemiology of adenovirus infections in newborn infants]. PMID- 4314988 TI - Adenyl cyclase activity in Morris hepatomas 7777, 7794A, and 9618A. PMID- 4314989 TI - Changes in the nucleotide compositions of nucleolar 45 S RNA of azo dye-induced hepatoma. PMID- 4314990 TI - Release of leukemia C particles from murine cell lines infected with Bittner virus-containing inocula. PMID- 4314991 TI - Occurrence, pathological features, and propagation of gonadal teratomas in inbred mice and in rabbits. PMID- 4314992 TI - Benzpyrene hydroxylase activity and its induction by methylcholanthrene in Morris hepatomas, in host livers, in adult livers, and in rat liver during development. PMID- 4314993 TI - The biocleavage of alkyl glyceryl ethers in Morris hepatomas and other transplantable neoplasms. PMID- 4314994 TI - Nephroblastomas induced in ovariectomized rats by dimethylbenzanthracene. PMID- 4314995 TI - Cyclic nucleotides on cell growth in vitro. PMID- 4314996 TI - Metabolic adaptations in rat hepatomas: altered regulation of serine dehydratase synthesis by glucose and amino acids in hepatocellular carcinomas. PMID- 4314997 TI - Potentiation of the pressor response to angiotensin by amphetamine and ephedrine. PMID- 4314998 TI - Isolation of cyclic 3',5'-adenosine monophosphate on a neutral silicic acid-glass microfiber matrix. PMID- 4314999 TI - Intestinal microflora in a chronic carrier of Vibrio cholerae. PMID- 4315000 TI - Production of interferon by long-term suspension cultures of leukocytes derived from patients with viral and nonviral diseases. PMID- 4315001 TI - A new class of ultralong-acting local anesthetics. PMID- 4315002 TI - The antagonism of phentolamine against exogenously administered and endogenously released norepinephrine in rabbit aortic strips. PMID- 4315003 TI - Effects of metabolic inhibitors on norepinephrine release from the perfused spleen of the cat. PMID- 4315004 TI - Cholinergic activities of halogeno-acetylcholines. PMID- 4315005 TI - The actions of gamma-aminobutyric acid and related amino acids on mammalian autonomic ganglia. PMID- 4315006 TI - The bioelectrode, a new concept explaining the reaction mechanism of beef heart cytochrome c reductase. PMID- 4315007 TI - Enzyme activity calculations by curvilinear regression analysis. A program for a computing desk top calculator, used in the study of cytochrome c reductase and hyaluronidase. PMID- 4315008 TI - [Hystochemistry of some enzymes in uterine myoma]. PMID- 4315009 TI - [Use of iodolipol and ether for direct lymphangioadenography]. PMID- 4315010 TI - Carbohydrate changes in liver disease. PMID- 4315012 TI - Methylation of mouse DNA in vivo: di- and tripyrimidine sequences containing 5 methylcytosine. PMID- 4315013 TI - Activation of thymidine kinase of adult rat liver by the culture filtrate of Clostridium perfringens. PMID- 4315014 TI - Inactivation of thymidylate kinase by a microsomal factor. PMID- 4315011 TI - Allosteric controls of amphilbolic pathways in bacteria. PMID- 4315015 TI - Biochemical and biological characteristics of carbethoxylated poliovirus and viral RNA. PMID- 4315017 TI - On the effect of chloramphenicol and oxytetracycline on the biogenesis of mammalian mitochondria. PMID- 4315016 TI - Characterization and cell-free activity of polyribosomes isolated from baby hamster kidney cells. PMID- 4315018 TI - Ornithine decarboxylase activity in relation to growth of rat liver. Effects of partial hepatectomy, hypertonic infusions, celite injection or other stressful procedures. PMID- 4315019 TI - Purification of an ATP-dependent nuclease from Micrococcus lysodeikticus. PMID- 4315020 TI - Effect of 3',5'-AMP on a step after the transcription of the lactose messenger RNA. PMID- 4315021 TI - Preparation of bactoprenyl pyrophosphate. PMID- 4315022 TI - [Sources of aphthous fever virus used in Italy for production of inactivated antiaphthous fever vaccines]. PMID- 4315023 TI - [Study of the modified variants of aphthous fever virus]. PMID- 4315024 TI - [Column culture of aphthous fever virus on bovine lingual epithelium]. PMID- 4315025 TI - [Attempted adaptation of the Belgian anti-aphthous fever vaccine to the O-1 strain]. PMID- 4315026 TI - [Culture of the aphthous fever virus on bovine lingual epithelium: importance of early contact between the virus and epithelium]. PMID- 4315027 TI - [Study of the cultivation of the aphthous fever virus on bovine lingual epithelium. Current prospects]. PMID- 4315028 TI - [Studies of the structure of the aphthous fever virus and of the antigenicity of its protein fractions]. PMID- 4315029 TI - [Serological study (serological relationships) of a strain of aphthous fever virus, type "O", isolated in Great Britain]. PMID- 4315030 TI - [Multiplication of the aphthous fever virus, variant A 22, in explants of lingual epithelium of cattle with prior aphthous fever]. PMID- 4315031 TI - [Study with microcinematography of tissue culture cells in the normal state and after contamination with aphthous fever virus A 22 and its RNA]. PMID- 4315032 TI - [Study of strains of aphthous fever virus of type A]. PMID- 4315033 TI - [Study of the influence of certain physico-chemical factors on aphthous fever virus and the elements of its structure]. PMID- 4315034 TI - [Comparative serological study of strains of aphthous fever virus of type O isolated in the Middle East and Europe]. PMID- 4315035 TI - [Use of BHK-21 culture in suspensions for the multiplication of aphthous fever virus and the preparation of aphthous fever vaccines]. PMID- 4315036 TI - [Effect of neuroleptics of phenothiazine series on the summation of impulses in central nervous system]. PMID- 4315037 TI - [Correlation between impulse activity of single neurons and high frequency electrocorticogramm in physostigmine and phenamine desynchronizations]. PMID- 4315038 TI - [Dependence between chemical structure and physiological effect in series of aminoketols]. PMID- 4315039 TI - [Increase in resistance of brain to oxygen deficiency by means of gutimine and N methyl-phenazine-metasulfate]. PMID- 4315040 TI - [Effect of salts of ethylenediamine tetraacetic acid and sodium dimercaptopropane sulfonate on hemolytic activity of alpha-toxin of Clostridium perfringens]. PMID- 4315042 TI - The length and diameter of the node of Ranvier. PMID- 4315041 TI - [Changes of some biochemical indices in the organism during inhalation effect of small concentrations of tetrabromethane]. PMID- 4315043 TI - Surgic grand rounds. PMID- 4315044 TI - Carcinosarcoma and mixed mesodermal tumor of the uterine corpus. Review of 49 cases. PMID- 4315045 TI - The preparation of 2'-O-methylcytidine-5'-mono and pyrophosphate, and poly-2'-O methylcytidylic acid. PMID- 4315046 TI - [Vulvar cancer and colored lymphoradioisotopotherapy]. PMID- 4315047 TI - Behavious of turkey pox virus during adaptation to embryonic pig kidney epithelial cell cultures. PMID- 4315048 TI - The effect of pH on the characteristics of the binding of nicotinamide-adenine dinucleotide by nicotinamide-adenine dinucleotide-specific isocitrate dehydrogenase from pea mitochondria. AB - 1. The effect of pH on the V(max.) and concentration of NAD(+) at half-maximum velocity at a constant isocitrate concentration was examined, and the results were related to the requirements for binding of H(+) ions to the enzyme. 2. The effect of varying the NAD(+) concentration on the pH optimum with constant isocitrate concentration was studied. 3. A comparison has been made between the effect of isocitrate concentration on the characteristics of binding of NAD(+) and the effect of NAD(+) concentration on the characteristics of isocitrate binding at three different pH values. 4. The mechanistic and metabolic significance of these studies is considered. PMID- 4315050 TI - The relation between phospholipase action and release of NADH dehydrogenase from mitochondrial membrane. PMID- 4315049 TI - Fractionation of liver plasma membranes prepared by zonal centrifugation. AB - 1. Plasma membranes were isolated from crude nuclear sediments from mouse and rat liver by a rate-dependent centrifugation through a sucrose density gradient contained in the ;A' type zonal rotor. 2. The membranes were further purified by isopycnic centrifugation, and characterized enzymically, chemically and morphologically. 3. When the plasma-membrane fraction of sucrose density 1.17g/cm(3) was dispersed in a tight-fitting homogenizer, two subfractions of densities 1.12 and 1.18 were obtained by isopycnic centrifugation. 4. The light subfraction contained 5'-nucleotidase, nucleoside diphosphatase, leucine naphthylamidase and Mg(2+)-stimulated adenosine triphosphatase activities at higher specific activities than unfractionated membranes. The heavy subfraction was deficient in the above enzymes but contained higher Na(+)+K(+)-stimulated adenosine triphosphatase activity. 5. The light subfraction contained twice as much phospholipid and cholesterol, and three times as much N-acetylneuraminic acid relative to unit protein weight as the heavy subfraction. Polyacrylamide-gel electrophoresis indicated differences in protein composition. 6. Electron microscopy showed the light subfraction to be vesicular. The heavy subfraction contained membrane strips with junctional complexes in addition to vesicles. PMID- 4315051 TI - Cellular membranes: membrane marker enzyme activities in synchronized mouse leukemic cells L5178Y. PMID- 4315052 TI - The effect of calcium on amylase secretion by rat parotid slices. PMID- 4315053 TI - Purification and separation of alpha- and beta-galactosidases from spinach leaves. PMID- 4315054 TI - Studies on the angiotensin converting enzyme with different substrates. PMID- 4315055 TI - Immunologic relationship of a purified human skin collagenase to other human and animal collagenases. PMID- 4315056 TI - Intracellular distribution of palmitoyl-CoA synthetase in rat liver. PMID- 4315057 TI - The ternary complexes of fatty acid amides with horse liver alcohol dehydrogenase and NA+. PMID- 4315058 TI - Effect of the urea-urease system and the carbonate ion on the activities of lactate dehydrogenase isoenzymes. PMID- 4315059 TI - Spectrophotometric studies of binary and ternary complexes of octopine dehydrogenase. PMID- 4315060 TI - Myeloperoxidase of the leukocyte of normal blood. I. Reaction of myeloperoxidase with hydrogen peroxide. PMID- 4315062 TI - [Phosphodiesterases of Actinomyces No 5 of the coelicolor type]. PMID- 4315061 TI - The vascular responses of the spleen to intravenous infusions of catecholamines, angiotensin and vasopressi in the anaesthetized cat. AB - 1. Splenic arterial flow and splenic weight were recorded in cats anaesthetized with sodium pentobarbitone. The responses of the spleen to catecholamines, angiotensin and vasopressin were investigated.2. Catecholamines caused responses mediated by alpha- and beta-adrenoceptors in the arteriolar smooth muscle, but only insignificant beta-adrenoceptor responses could be elicited from the capsular smooth muscle. The difficulties in elucidating the mechanism of action of catecholamines on arteriolar smooth muscle are discussed.3. Angiotensin caused marked vasoconstriction, but contraction of the capsular smooth muscle was less marked. Vasopressin caused vasoconstriction but had no effect on capsular smooth muscle. Thus these peptides constrict the resistance vessels but produce much weaker contraction of the capsule.4. These responses are discussed in relation to the splenic responses to acute haemorrhage. PMID- 4315063 TI - A comparative study of rat liver, spleen and skin lysosomes. PMID- 4315064 TI - Recruiting responses in the cerebral cortex produced by putamen and pallidum stimulation. PMID- 4315065 TI - Excitability of the lateral geniculate nucleus in the alert, non-alert and sleeping cat. PMID- 4315066 TI - Reciprocal lateral inhibition of on- and off-center neurones in the lateral geniculate body of the cat. PMID- 4315067 TI - [Management of women with ovarian cancer]. PMID- 4315068 TI - [Studies on homogeneity of poliomyelitis virus strains. I. The RTC-40 marker in attenuated virus clones]. PMID- 4315069 TI - [Cytochemical study of human thyroid gland cells infected with SV40 virus]. PMID- 4315070 TI - [Use of paper electrophoresis for separation of viomycin from the accompanying substances]. PMID- 4315071 TI - [Data on therapy of Syndenham's chorea. Case records of the Clinica Pediatrica of Geno during the period 1955-1966]. PMID- 4315072 TI - [Anti-SV-40 complement-fixing antibodies in tumors of childhood]. PMID- 4315073 TI - [Pathogenesis of bone changes in glycogenosis. I. Nephrogenic rickets in type I glycogenosis]. PMID- 4315074 TI - Action of guanethidine on the pressor effect of angiotensin in adrenalectomized dogs. PMID- 4315075 TI - Measurement of adenosine 3',5'-monophosphate (cyclic AMP) in brain. PMID- 4315076 TI - The effect of desmethylimipramine and theophylline on plasma free fatty acids and blood glucose in rats. PMID- 4315077 TI - [Radio-immunologic determination of plasma ACTH]. PMID- 4315078 TI - [Chiari's anomaly]. PMID- 4315079 TI - [99m Technetium pertechnetate for barin photo-scintigraphy]. PMID- 4315080 TI - [Secretion in the endocrine tissues in vitro]. PMID- 4315081 TI - [Use of corticotropin, dexamethasone and metyrapone in the differential diagnosis of Cushing's syndrome and corticosteromas]. PMID- 4315082 TI - [Influence of beta-adrenergic processes on the adrenal cortex function]. PMID- 4315083 TI - [Effect of corticotropin on the metabolism and distribution of sulfur-containing proteins in the adrenal gland cortex]. PMID- 4315084 TI - [Effect of glutamic and diverse other amino acids on the biosynthesis of glucocorticoids in the adrenal glands]. PMID- 4315085 TI - [Personal experience with saccoradiculography using methylglucamine iothalamate]. PMID- 4315086 TI - [Analysis of transmission potentials across the corpus callosum during electric silence]. PMID- 4315087 TI - Vasopressin: effect on deformability of urinary surface of collecting duct cells. AB - In isolated renal collecting ducts vasopressin decreased the negative pressure required to suck a hemispherical bulge of the epitheliat cells' urinary surface into the tip of a micropipette. Increased surface deformability may be related to the increased permeability to water which also occurs in the apex of the cells in response to the hormone. PMID- 4315089 TI - Paget's disease of the breast. PMID- 4315088 TI - Endocrine studies in the arrhenoblastoma. PMID- 4315090 TI - [Possibilities of induction of rat liver lysosomal enzymes by phenobarbital. 1. Beta-glucuronidase, beta-acetylglucosaminidase and collagenase]. PMID- 4315091 TI - Intermittent tetracosactrin-depot therapy in dermatology. PMID- 4315092 TI - Congenital anomaly: cutaneous pigmentation and atrophy with partial webbing of digits. PMID- 4315093 TI - Effects of amiloride on active sodium transport by the isolated frog skin: evidence concerning site of action. AB - 1. Amiloride reduces short-circuit current and potential difference across the isolated frog skin.2. Isotopically measured sodium influx and efflux are diminished.3. Total electrical conductance and partial sodium conductance are diminished, the reduction in total conductance being entirely accounted for by the reduction in partial sodium conductance.4. The effect of antidiuretic hormone (ADH), cyclic 3'5'-adenosine monophosphate (cyclic AMP) and theophylline can be antagonized by pretreatment with amiloride but the antagonism can be abolished by increasing the concentration of these compounds.5. Amiloride has no effect on oxygen consumption in concentrations which inhibit sodium transport. However, it prevents the stimulatory effect of ADH on oxygen consumption.6. The results are consistent with an action of amiloride at the passive outside membrane of the transporting cells of isolated frog skin. PMID- 4315094 TI - The effect of betamethasone on circadian and stress-induced pituitary adrenocortical function in the rat. AB - 1. Both the circadian and stress-induced changes in plasma corticosterone concentration were abolished by the inclusion of betamethasone in the drinking water of rats.2. Adrenal sensitivity to exogenous corticotrophin (ACTH) was unimpaired by the betamethasone treatment.3. The normal circadian rhythm in plasma corticosterone returned within 1 day of withdrawal of the steroid, but the response to stress was normal only after 3 days.4. The possible significance of these observations is discussed. PMID- 4315095 TI - [Glomus jugularge tumor. Non-chromaffin paraganglioma]. PMID- 4315096 TI - Changes in interscapular brown adipose tissue of the rat during perinatal and early postnatal development and after cold acclimation. I. Activities of some respiratory enzymes in the tissue. PMID- 4315097 TI - Temperature adaptation and the phospholipids of membranes in goldfish (Carassius auratus). PMID- 4315098 TI - Feline viruses. VII. Immunity to the feline herpesvirus in kittens inoculated experimentally by the aerosol method. PMID- 4315099 TI - Changing concepts in the histopathologic diagnosis of polypoid lesions of the colon. PMID- 4315100 TI - Dietary and hormonal effects on gluconeogenesis and glycogenesis from pyrute-3 14C, fructose-U-14C and glycerol-2-14C in the rat. PMID- 4315101 TI - Hypothalamic stimulation of growth hormone and thyrotropin lease in vitro and pituitary 3'5'-adenosine cyclic monophosphate. PMID- 4315102 TI - Effect of procine beta melanocyte-stimulating hormone on blood lymphocyte count and serum corticosterone concentration of the rabbit. PMID- 4315103 TI - Prostaglandins: stimulation of bone resorption in tissue culture. PMID- 4315104 TI - Bovine virus diarrhea: infectious bovine rhinotracheitis complex. PMID- 4315105 TI - Role of parainfluenza-3 in cattle. PMID- 4315106 TI - Field use of bovine vaccines. PMID- 4315107 TI - [Studies on respiratory syncytial (RS) virus]. PMID- 4315108 TI - [Radiation therapy of juvenile angiofibromas at the base of the skull]. PMID- 4315110 TI - Successful localization of a pancreatic islet cell adenoma by selective celiac angiography. PMID- 4315109 TI - Studies with pinealectomized rats. PMID- 4315111 TI - Squirrel viruses. PMID- 4315112 TI - Cell-virus interaction in virus-induced animal tumours. PMID- 4315113 TI - Are observations on tumour viruses in animals applicable to man? PMID- 4315115 TI - [On feminizing tumors of the ovary]. PMID- 4315114 TI - In vitro lymphocyte response in some immunity deficiency diseases and in intrauterine virus infections. PMID- 4315116 TI - Clinical value of exercise tests in childhood asthma. PMID- 4315117 TI - The pathogenesis and treatment of collagenase-induced diseases of the cornea. PMID- 4315118 TI - The diurnal variation of the concentration of corticosterone in plasma in experimental trypanosomiasis in mice. PMID- 4315119 TI - Estimation of young peoples' ages by a radiological method. PMID- 4315120 TI - Advances in viral hepatitis. PMID- 4315121 TI - Mitochondrial changes during the malarial life cycle. PMID- 4315122 TI - [Malignant malanoma of the penis]. PMID- 4315123 TI - Ammonium acid urate calculus in a cat with a high uric acid excretion possibly due to a renal tubular reabsorption defect. PMID- 4315124 TI - [Sleep and REM]. PMID- 4315125 TI - [Hidradenoma of the vulva]. PMID- 4315126 TI - [Antineoplastic antibiotics from Streptomycetes]. PMID- 4315127 TI - [Antagonism of circulation effect of adenosine by theophylline]. PMID- 4315128 TI - [Experimental studies concerning sensitizing side effects of tetracosactide]. PMID- 4315129 TI - [Effect of diisopropylfluorophosphate (DFP) on alcohol dehydrogenase (E.C. 1.1.1.1.)]. PMID- 4315130 TI - Environment of copper in Pseudomonas fluorescens azurin: fluorometric approach. PMID- 4315131 TI - Iron-mercaptoethanol-inorganic sulfide complex. Possible model for the chromophore of nonheme iron proteins. PMID- 4315132 TI - Electron paramagnetic resonance studies of cob(II)alamin and cob(II)inamides. PMID- 4315133 TI - Reconstitution of tobacco mosaic virus: calorimetric and related studies. PMID- 4315134 TI - Structure of Klebsiella aerogenes type 8 polysaccharide. PMID- 4315135 TI - A novel reaction involved in the degradation of apiogalacturonans from Lemna minor and the isolation of apibiose as a product. PMID- 4315136 TI - Lipolysis and alpha-aminoisobutyric acid uptake in isolated fat cells. Effects of insulin and lipolytic agents. PMID- 4315137 TI - Lipolysis and potassium accumulation in isolated fat cells. Effect of insulin and lipolytic agents. PMID- 4315139 TI - Degradation of steroids by intestinal bacteria. I. Deconjugation of bile salts. PMID- 4315138 TI - ATP content of isolated fat cells. Effects of insulin, ouabain, and lipolytic agents. PMID- 4315140 TI - Relation between electrophoretic charge of phospholipids and the activating effect on protoheme ferro-lyase. PMID- 4315141 TI - Oxidation of urinary 17-oxogenic steroids with sodium metaperiodate. PMID- 4315142 TI - A cause of apparently abnormal urinary 17-hydroxy corticosteroids responses to metyrapone in normal subjects. PMID- 4315143 TI - The fine structure of nuclear inclusions. PMID- 4315144 TI - The assessment of skeletal maturity in the growing rat. PMID- 4315145 TI - Radiographic analysis of foetal mortality in a litter of piglets. PMID- 4315146 TI - Effects of O2 and CO2 on airway smooth muscle following pulmonary vascular occlusion. PMID- 4315147 TI - Regulation of phosphoenolpyruvate metabolism in mitochondria from guinea pig liver. PMID- 4315148 TI - Differences in the thermal inactivation properties of lysyl and arginyl transfer ribonucleic acid synthetases of bakers' yeast. PMID- 4315149 TI - Regulation of lac messenger ribonucleic acid synthesis by cyclic adenosine 3',5' monophosphate and glucose. PMID- 4315150 TI - Studies on the reaction mechanism of skeletal muscle phosphofructokinase. PMID- 4315151 TI - The control of ribonucleic acid synthesis in Escherichia coli. V. Characterization of a nucleotide associated with the stringent response. PMID- 4315152 TI - Metabolic interlock. The influence of histidine on tryptophan biosynthesis in Bacillus subtilis. PMID- 4315153 TI - Adrenal cells in tissue culture. V. On the specificity of the stimulation of 11beta-hydroxylation by adrenocorticotropin. PMID- 4315154 TI - Further studies on synaptic transmission in insects. I. External recording of synaptic potentials in a single giant axon of the cockroach, Periplaneta americana L. PMID- 4315155 TI - Differential blockage and potentiation of transmission in a sympathetic ganglion. PMID- 4315156 TI - Effects of phenothiazine derivatives on biological membranes: drug-induced changes in electron spin resonance spectra from spin-labeled erythrocyte ghost membranes. PMID- 4315157 TI - Virus-specific antigens in hamster cells transformed by Rous sarcoma virus. AB - Virus-specific antigens were studied in hamster cells transformed by Rous sarcoma virus (RSV). Antigens were localized in the cytoplasm, as demonstrated by fluorescent antibody staining of fixed cells as well as by complement fixation (CF) following subcellular fractionation. Cytoplasmic extracts were analyzed by velocity and isopycnic centrifugation. CF antigens were found in a soluble form and in association with membranes and polyribosomes. Isolated plasma membranes had no CF antigen. Both soluble and particulate fractions with CF activity contained the same antigenic determinants by Ouchterlony analysis. These antigenic determinants were identical to those released by ether treatment of RSV. PMID- 4315158 TI - Characterization of bluetongue virus ribonucleic acid. AB - An improved purification procedure yielded bluetongue virus free from any single stranded ribonucleic acid (RNA) component. Double-stranded RNA obtained from purified virus or isolated from infected cells was fractionated into 5 components by means of sucrose gradient sedimentation analysis, and into 10 components by electrophoresis on polyacrylamide gels. The size of these components vary from 0.5 x 10(6) to 2.8 x 10(6) daltons, with a total molecular weight estimate of about 1.5 x 10(7) for the viral nucleic acid. The denaturation of the genome and separation of the resulting fragments are also discussed. PMID- 4315159 TI - Protection of vaccinia from heat inactivation by nucleotide triphosphates. AB - The presence of adenosine triphosphate, guanosine triphosphate, cytosine triphosphate, or uridine triphosphate reduced the rate of inactivation of vaccinia when heated at 50 C. The virus-associated nucleoside triphosphate phosphohydrolases (adenosine triphosphatase, guanosine triphosphatase, cytosine triphosphatase, and uridine triphosphatase) and ribonucleic acid polymerase were also protected from heat inactivation by these compounds. These obervations are best explained by postulating that ribonucleoside triphosphates bind to enzymes in the virus particle, and that these enzyme-substrate complexes are more resistant to thermal denaturation than are the enzymes without their substrates. The kinetics of heat inactivation of the vaccinia ATP phosphohydrolase activity is biphasic, suggesting that there are two proteins in the vaccinia particle that have this enzyme activity but they have different kinetics of heat inactivation. Any of the vaccinia-associated nucleotide phosphohydrolase activities are protected from heat inactivation by the presence of any one of the respective nucleoside triphosphates. This observation suggests that there is a single enzymatic site in vaccinia that is able to react with any ribonucleoside triphosphate. PMID- 4315160 TI - Type 1 and type 2 herpes simplex viruses: serological and biological differences. AB - Forty isolates of herpes simplex virus were compared by means of cross neutralization curves. The 11 oral isolates were serotype 1, and all 29 genital/anal isolates were serotype 2. The cytopathic effects of the two serotypes were consistently different. Passage of strains of type 1 and type 2 in mice and in rabbits yielded two variants, although the majority of the strains remained unchanged serologically and in their cytopathic effects. The two variants were derived from type 1 strains and differed from the parent strains in their cytopathic effects, each of them producing syncytia and enlarged plaques. They had, however, retained the serotypic properties and the deoxyribonucleic acid (DNA) densities of their parent strains. The Roizman syncytial/macroplaque strain of herpes simplex virus was also included in the study; the density of its DNA (1.727 g/ml) was typical of type 1 strains, and serologically it seemed to be basically a type 1 strain, although it was neutralized by type 2 antiserum slightly better than were other type 1 strains. Growth curves were performed of the two serotypes in rabbit kidney, human fibroblast, and mouse embryo tissue cultures. The type 2 strains attained lower titers of infectivity in these three cell systems; the levels of infectivity of type 2 virus in the culture fluid decreased much more rapidly after the maximum had been attained than did the levels of infectivity of the type 1 strains, due to the greater instability of the type 2 virus. Parallel titrations of different strains in tissue cultures and intracerebrally in mice indicated that the latter assay system was usually more sensitive for type 2 strains than it was for type 1 strains. The paralytic sequelae and inflammatory changes of lumbar ganglia and spinal cord in young rabbits inoculated extraneurally with strains of the two serotypes also indicate that the type 2 virus is more virulent in laboratory animals than is type 1 virus. PMID- 4315162 TI - Eight postulates in allergy. PMID- 4315163 TI - [Roentgenotherapy of acute inflammatory affections in the surgical practice]. PMID- 4315161 TI - Inhibition of Sindbis virus production by media of low ionic strength: intracellular events and requirements for reversal. AB - Incubation of Sindbis virus-infected cultures in medium with an ionic strength of 0.105 reduced the virus yield more than 99%. This inhibition was rapidly reversed by exposing the cultures to normal medium: within 20 min the previously inhibited cultures had released as much infectious virus as normal controls had produced during hours of incubation. The following intracellular processes were essentially normal in inhibited, infected monolayers: protein and phospholipid synthesis, the synthesis of infectious viral ribonucleic acid and its incorporation into nucleocapsids, and viral modification of the cell membrane. Accelerated virus production was detected within 20 sec after exposure of inhibited cultures to normal medium. It required an ionic strength greater than 0.145, a pH above 6.7, and a temperature above 21 C. It was not dependent on osmotic pressure, de novo protein synthesis, or a functional energy metabolism. Virus release also occurred in sonic-treated materials of inhibited cells under the same conditions as in living cells. Potential applications of the inhibition to concentration of virus stocks or to obtaining virus in nonphysiological solutions are noted. Preliminary studies with Semiliki Forest virus, Newcastle disease virus, and vesicular stomatitis virus suggest that this phenomenon may be limited to arboviruses. PMID- 4315164 TI - Recurrent polyneuropathy with pregnancy and oral contraceptives. PMID- 4315165 TI - [Etiological structure of viral respiratory diseases in children under 7]. PMID- 4315166 TI - [The renin-angiotensin-aldosterone system in 2 cases of Schwartz-Bartter syndrome]. PMID- 4315167 TI - Radiation-induced radicals in thymine: ESR studies of single crystals. PMID- 4315168 TI - The subcellular distribution of plutonium in rat liver. PMID- 4315170 TI - [Lipoma of the stomach]. PMID- 4315169 TI - [Pseudo-tumorous appearance of esophagitis with hiatal hernia. Spasmodic obstruction of the terminal esophagus and enclosure of food particles]. PMID- 4315171 TI - [Voluminous submucosal gastric lipoma revealed by hematemesis]. PMID- 4315172 TI - [Double cancerized ulcer of the body of the stomach. Diagnosis by guided gastric biopsy]. PMID- 4315173 TI - [Degenerated peptic ulcer]. PMID- 4315174 TI - [3 cases of cancer appearing on operated stomachs]. PMID- 4315175 TI - [Leiomyosarcoma of the duodenum]. PMID- 4315176 TI - [Primary malignant pseudotumor of the duodenum (propagating cancers of the pancreas)]. PMID- 4315177 TI - [Primary Hodgkin's disease of the small intestine presenting as staged stenosis of the duodenum, jejunum and ileum]. PMID- 4315178 TI - [Hodgkin's disease with perforated small intestine]. PMID- 4315179 TI - [Fibro-leiomyoma of the small intestine]. PMID- 4315180 TI - [A further case of Peutz-Jeghers syndrome]. PMID- 4315181 TI - [Extensive ileo-cecal-colonic tuberculosis]. PMID- 4315182 TI - [Crohn's disease with ileo-cecal localization]. PMID- 4315183 TI - [Total colonic Crohn's disease]. PMID- 4315184 TI - [Polyps of the colon]. PMID- 4315185 TI - [Cases of pyopneumocholecystitis and peripneumocholecystitis due to gangrene and covered perforations of the gallbladder]. PMID- 4315186 TI - [Residual lithiasis of the common bile duct with stenosis of a choledocho duodenal anastomosis]. PMID- 4315187 TI - [Biliary ileus and postoperative adhesions]. PMID- 4315188 TI - [Importance of celio-mesenteric arteriography in pancreatic surgery]. PMID- 4315189 TI - [A very unusual hernia]. PMID- 4315190 TI - [Fatal diastatic perforation of a strangulated post-traumatic diaphragmatic hernia]. PMID- 4315191 TI - [Amnesic ictus]. PMID- 4315192 TI - [Primary cholesteatoma of the ear]. PMID- 4315193 TI - [Infections following induced immune deficiencies]. PMID- 4315194 TI - [Primary congestive heart failure during myasthenia]. PMID- 4315195 TI - [Terminal cerebral localization of hepatic and pulmonary alveolar echinococcosis]. PMID- 4315196 TI - [General practitioner and mental diseases in patients]. PMID- 4315197 TI - Persistent polyagglutinability in vivo unrelated to T-anigen activation. PMID- 4315199 TI - [On bronchial cylindroma. (Observations on a personal case)]. PMID- 4315198 TI - [Transplacental induction of malignant tumours of the nervous system. II. Ethyl nitrosurea in 10 genetically defined strains of rats]. PMID- 4315200 TI - [Panmyelophthisis and viral hepatitis. Experimental study with the MHV3 mouse hepatitis virus]. PMID- 4315201 TI - The use of iodized oil in goiter prevention. PMID- 4315202 TI - Neuromuscular transmission and hypocalcemic paresis in the cow. PMID- 4315203 TI - Perianal Paget's disease. PMID- 4315204 TI - Tracheobronchial adenomas. PMID- 4315205 TI - [Molecular weight and number of ionogenic groups of ristomycins and related antibiotics]. PMID- 4315206 TI - Sleep patterns in normal and psychotic children. PMID- 4315207 TI - I. Cultivation conditions and mixed lymphocyte interaction of mouse peripheral lymphocytes. PMID- 4315208 TI - Lymphocyte transformation in patients with amyloidosis. PMID- 4315209 TI - Inorganic pyrophosphate and pyrophosphatases in clcification and calcium homeostasis. PMID- 4315210 TI - Morphologic and biochemical aspects of experimental extraosseous tissue calcification. PMID- 4315211 TI - Hypothenar mass and ulnar neuropathy. A case report. PMID- 4315212 TI - Quantitative microchemical studies of chondroblastoma, giant-cell tumor, chondromyxoid fibroma and desmoplastic fibroma. PMID- 4315213 TI - Studies on the identity of a vascular permeability factor of renal origin. PMID- 4315214 TI - Kinetics for free-radical conversion processes in irradiated D,L-valine. PMID- 4315215 TI - Luteinizing hormone-releasing factor discharged by dopamine in rats. PMID- 4315216 TI - Intraneural ganglionic cyst of the peroneal nerv Case report. PMID- 4315217 TI - Inhibitory effect of rabbit bile on renin angiotensinogen reacton system. PMID- 4315218 TI - [Cytomegaly as concomitant infection in acute leukemia]. PMID- 4315220 TI - [Comparative studies on the content of adenine and pyridine nucleotides, hexose phosphates and triglycerides in the blood of latent and manifest diabetics]. PMID- 4315221 TI - Studies on ethanl-induced stimulation of glucose-6-phosphatase activity. PMID- 4315219 TI - [Adrenal gland function test in children using fluorometric 11-hydroxy corticosteroid (11-OHCS) determination in the urine following intravenous administration of synthetic ACTH preparations]. PMID- 4315222 TI - Trial of mannoheptulose in man. PMID- 4315223 TI - Activity of kinin-releasing enzymes in the mammary gland of rats administered with hormones and bacterial extracts. PMID- 4315224 TI - Screening tests of pulmonary function. PMID- 4315225 TI - Neuropathy in uremia. PMID- 4315226 TI - Skeletal muscle relaxants. PMID- 4315227 TI - Pharmaco-microangiography: an experimental technique. PMID- 4315228 TI - Physiological concentrations of lactate dehydrogenases and substrate inhibition. AB - Lactate dehydrogenases at physiological concentrations are inhibited by high concentrations of pyruvate when the enzyme and the pyruvate are incubated in the presence of oxidized nicotinamide-adenine dinucleotide before assay. The inhibition is much more pronounced with the H-type than with the M-type lactate dehydrogenase. These results suggest that substrate inhibition may be operative in vivo. PMID- 4315229 TI - ["Cancer-chronic lymphoid leukemia" association. 27 cases extracted from a series of 365 cases of chronic lymphoid leukemia and review of the literature]. PMID- 4315230 TI - [Delayed cutaneous reaction to red ant (Formica Ruffa) bites. (Warty and necrotic skin granuloma)]. PMID- 4315231 TI - [L-Asparaginase in the treatment of acute leukemia]. PMID- 4315232 TI - [Suicide attempts by adolescents. Study of 70 cases]. PMID- 4315233 TI - [Mechanism of renal compensation in diabetes mellitus. Adaptation of the urinary osmolarity as a phenomenon of compensation in diabetes mellitus. I. Clinico physiological experiment]. PMID- 4315234 TI - [Mechanism of renal compensation in diabetes mellitus. Adaptation of urinary osmolarity as a phenomenon of compensation in diabetes mellitus. II. Study of 75 cases]. PMID- 4315235 TI - [Satisfactory prophylaxis of urinary lithiasis with D-penicillamine in cystinuria]. PMID- 4315236 TI - [Transient synovitis of the hip]. PMID- 4315237 TI - [Uterine gas gangrene with haemolysis and anuria following spontaneous abortion]. PMID- 4315238 TI - Amino-terminal analysis of submaxillary mucins. PMID- 4315239 TI - On the mechanism of renin stimulation. The effect of postural change, salt depletion and exercise. PMID- 4315240 TI - [Addison's disease and Basedow's disease]. PMID- 4315241 TI - [Diagnostic problems in Cushing's disease]. PMID- 4315242 TI - [Dangers of prolonged corticotherapy]. PMID- 4315244 TI - [Meningeal tumors (anatomopathological review)]. PMID- 4315243 TI - [Histogenesis of cylindromas]. PMID- 4315245 TI - Forward vs reversed Bekesy tracings. PMID- 4315246 TI - Collagenase and rheumatoid arthritis. PMID- 4315247 TI - The participation of I- and 2-isomers of O-alkylglycerols as acyl acceptors in cell-free systems. PMID- 4315248 TI - Control of lipid metabolism in hepatomas: effects of fasting and dietary fat on the activities of several glycolytic and Krebs-cycle enzymes in mouse liver and hepatoma BW 7756. PMID- 4315249 TI - Di- and triphosphoinositide metabolism in swine erythrocyte membranes. PMID- 4315250 TI - Di- and triphosphoinositide metabolism in intact swine erythrocytes. PMID- 4315251 TI - Reduction of dehydroepiandrosterone sulfate in the liver during ethanol metabolism. PMID- 4315252 TI - Lipids of ocular tissues. II. The phospholipids of mature bovine and rabbit whole retina. PMID- 4315253 TI - Synthesis of corticotropin peptides. IX. Synthesis of [1-glycine]-ACTH(1-18) octadecapeptide amide. PMID- 4315254 TI - Immunogenicity of hemocyanin for the mouse. PMID- 4315255 TI - Conversion of ATP by mouse lung preparations and by an extract of Bordetella pertussis. PMID- 4315256 TI - Thymidine incorporation into deoxyribonucleic acid by isolated rat liver mitochondria. PMID- 4315257 TI - Mechanism of gene expression in Tenebrio molitor. Juvenile hormone determination of translational control through transfer ribonucleic acid and enzyme. PMID- 4315258 TI - Studies on poly adenosine diphosphate-ribose. 8. A method for purification of poly adenosine diphosphate-ribose. PMID- 4315259 TI - The anthranilate synthetase-anthranilate 5-phosphoribosylpyrophosphate phosphoribosyltransferase aggregate. Catalytic and regulatory properties of aggregated and unaggregated forms of anthranilate 5-phosphoribosylpyrophosphate phosphoribosyltransferase. PMID- 4315260 TI - Studies on the formation of transfer ribonucleic acid-ribosome complexes. VII. The role of the 3'-hydroxyl-terminal end of transfer ribonucleic acid for interaction with ribosomes and ribosomal subunits. PMID- 4315261 TI - Stimulant effect of a heart infusion on streptococcal nicotinamide adenine dinucleotidase (EC 3.2.2.5). (Preliminary report). PMID- 4315262 TI - Immunology of interferons. I. Immune response to protective and nonprotective interferons. PMID- 4315263 TI - Immunology of interferons. II. Heterospecific activities of human interferons and their neutralization by antibody. PMID- 4315264 TI - Production of hypersensitivity in the neonatal mouse. PMID- 4315265 TI - The use of an immunofluorescence technique for the determination of antibodies to cytomegalovirus strains in human sera. PMID- 4315266 TI - Uptake of viral particles by oyster leukocytes in vitro. PMID- 4315267 TI - The selectivity of the thrombin-induced platelet release reaction: subcellular localization of released and retained constituents. PMID- 4315268 TI - [Congenital malformations in newborn infants in Zagreb]. PMID- 4315269 TI - [Which diagnosis would you make?]. PMID- 4315270 TI - Testing with metyrapone. PMID- 4315271 TI - Severe growth retardation in children with inflammatory bowel disease. PMID- 4315272 TI - The treatment of chronic uremia in childhood. I. Transplantation. PMID- 4315273 TI - [Reticulosarcoma of the small intestine revealed by malabsorption syndrome]. PMID- 4315274 TI - [Chordomas of the base of the skull]. PMID- 4315275 TI - [Auricular flutter of the 2-1 type revealing pulmonary embolism. A case]. PMID- 4315276 TI - [Medical doctrines during the Renaissance]. PMID- 4315277 TI - Total prosthetic transplantation of the inferior vena cava, with venous drainage restoration of the one remaining kidney on the graft, successfully performed on a child with Wilms' tumor. PMID- 4315278 TI - [Properties of polysilicic acid gels and conditions of the origin and development of life]. PMID- 4315279 TI - [Hepatitis in monkeys following inoculation with adenovirus from humans with viral hepatitis. II. Histopathological findings]. PMID- 4315280 TI - Experimental Herpes-T infection in hamsters. PMID- 4315281 TI - [The effect of high molar salt solutions on the thermo-inactivation of the foot and-mouth disease (FMD) virus]. PMID- 4315282 TI - [The necessity and production of germicidal types of paper. II]. PMID- 4315283 TI - [Inhibitory manifestations in the impulse activity of cat cochlear nucleus neurons]. PMID- 4315284 TI - [The electroencephalogram during dreams]. PMID- 4315285 TI - The effect of exogenic adrenaline on the concentration of cholesterol in the serum of rabbits with experimental atherosclerosis. PMID- 4315286 TI - Body movements during sleep. PMID- 4315287 TI - Ultrastructure of Entamoeba histolytica trophozoites obtained from the colon and from in vitro cultures. PMID- 4315288 TI - [Effect of cationic, anionic, non-ionogenic surface-active agents (SAA) and antibiotics on the loss of hyaluronidase from cells of Staphylococcus aureus]. PMID- 4315289 TI - [Metastatic tumors, melanoma, and sarcoma]. PMID- 4315291 TI - Cervical synovial sarcoma. PMID- 4315290 TI - Analytical studies on experimental skin calcification in the rat after administration of lead acetate and subsequent administration of polymyxin B sulphate. PMID- 4315292 TI - Some characteristics of human cancer tissues in vitro. PMID- 4315293 TI - Metanephric hamartomas and nephroblastomatosis in siblings. PMID- 4315294 TI - An incident of familial cancer, including 3 cases of osteogenic sarcoma. PMID- 4315295 TI - Tumors of minor salivary glands. A report of 73 cases. PMID- 4315296 TI - Clear-cell sarcoma of tendons and aponeuroses. Three additional cases. PMID- 4315297 TI - [Radiographic diagnosis of malignant synovialoma]. PMID- 4315298 TI - In-vivo and in-vitro conversion of angiotensin I to angiotensin II in dog blood. PMID- 4315299 TI - The structural and biochemical basis of movement disorders in treatment with neuroleptic drugs and in extrapyramidal diseases. PMID- 4315300 TI - Sleep characteristics of the human aged female. PMID- 4315301 TI - Solubilization of NADH-cytochrome b5 reductase from liver microsomes by lysosomal digestion. PMID- 4315302 TI - Purification and properties of NADH-cytochrome b5 reductase solubilized by lysosomes from rat liver microsomes. PMID- 4315303 TI - The kinetic behavior of the FMN and protoheme moieties of yeast L(plus)-lactate dehydrogenase (cytochrome b2). PMID- 4315305 TI - The influence of prepuberal ovariectomy, and subsequent hormone treatment, on vaginal opening in the rat. PMID- 4315304 TI - Urinary polypeptides related to collagen synthesis. AB - Of the total urinary hydroxyproline in normal subjects and those with skeletal disorders, between 4 and 20% was nondialyzable. In some patients with Paget's disease of bone, hyperparathyroidism with osteitis fibrosa, hyperphosphatasia, and extensive fibrous dysplasia the total urinary hydroxyproline was sufficiently high to permit purification of this polypeptide hydroxyproline by gel filtration and ion exchange chromatography. The partially purified polypeptides had molecular weights between 4500 and 10,000 and amino acid compositions and physical properties resembling those of gelatin. The polypeptide fractions also contained neutral sugar and glucosamine. These fragments had been shown to be susceptible to cleavage by purified bacterial collagenase suggesting the presence of the sequence-Pro-X-Gly-Pro-Y-. After administration of proline-(14)C to patients with Paget's disease hydroxyproline-(14)C was excreted in the urine. The hydroxyproline-(14)C specific activity reached a peak in 2-4 hr and declined rapidly. The specific activity of the polypeptide (retentate) portion was severalfold greater than that of the raw urine and diffusate. When the labeled urines were subjected to gel filtration the hydroxyproline-(14)C fractions of highest molecular weight which were eluted first from the columns had the highest specific activities. Exposure of the hydroxyproline-(14)C-containing polypeptides to bacterial collagenase rendered them dialyzable. Four patients with hyperparathyroidism and osteitis fibrosa were studied before and after removal of a parathyroid adenoma, a period of transition from a predominance of bone collagen resorption to one of relatively increased bone collagen synthesis. The total urinary hydroxyproline fell rapidly after operation whereas the ratio of the polypeptide fraction to the total rose three- to fourfold. The results of these studies suggest that the urinary polypeptides represent fragments of collagen related to collagen synthesis. Changes in the ratio of these peptides to total hydroxyproline in the urine may serve as an index of new bone formation in patients with skeletal disorders. PMID- 4315306 TI - Macrophage-melanocyte heterokaryons. I. Preparation and properties. AB - High yields of mouse macrophage-melanocyte heterokaryons and macrophage macrophage homokaryons were obtained through the virus-induced fusion of cells spread on a glass surface. After fusion there was a striking reorganization of cellular architecture by means of a colcemid-sensitive process. Heterokaryons were isolated through the use of differential trypsinization and many underwent division to form melanocyte-like hybrids. The selective uptake of dextran sulfate by macrophages served as a useful cytoplasmic marker in identifying hybrids. Many characteristic macrophage properties were altered in the heterokaryons. Within an hour of fusion macrophage nuclei became swollen, nucleoli were more prominent, and increased nuclear RNA synthesis occurred. 3 hr after fusion, a wave of DNA synthesis took place in the previously dormant macrophage nuclei. The fate of typical macrophage markers was examined in both heterokaryons and homokaryons. Macrophage homokaryons continued to exhibit active phagocytosis of sensitized erythrocytes, whereas this capacity was lost irreversibly in heterokaryons. The loss of phagocytic activity of heterokaryons occurred at an exponential rate and was accelerated by high concentrations of calf serum. Another macrophage surface marker, a divalent cation-dependent adenosine triphosphatase (ATPase), could be demonstrated histochemically on heterokaryons. Shortly after fusion, it was present in discrete regions, but it became more diffuse and disappeared within a day. Acid phosphatase-positive secondary lysosomes and retractile lipid droplets disappeared from heterokaryons but continued to accumulate in macrophage homokaryons. These observations indicate that typical macrophage properties cease to be expressed in heterokaryons, and melanocyte functions presumably predominate in heterokaryons and hybrids. PMID- 4315307 TI - Observations on the carrier state and related antibody titres during an outbreak of foot-and-mouth disease. AB - An outbreak of foot-and-mouth disease in a partially immune population of cattle in Botswana is described. The results show that when cattle immunized by vaccination were presented with natural field challenge of FMD, many animals with immunity sufficient to protect them against clinical disease were, however, susceptible to pharyngeal infection and subsequently became virus carriers. The proportion of animals becoming carriers appeared to vary with the degree of severity of the challenge.Vaccination before exposure to virus appeared to have little effect on the duration of the carrier state. No evidence was obtained of the spread of carrier virus to immune herds following the outbreak.Antibody titres during the outbreak were higher in the clinically infected animals than in the carrier animals and the uninfected animals. Evidence suggested that natural challenge boosted the titres of immune animals. After the outbreak, however, it was not possible to distinguish by their antibody titres between the carrier animal and the virus-negative animal.Antigenic studies on the strains of virus isolated are described. PMID- 4315308 TI - Studies on phosphorylase b kinase from neutral tissues. PMID- 4315309 TI - [Perfusion of the isolated liver: changes of the organo-cellular enzymatic activities as a function of time]. PMID- 4315310 TI - Application of automatic processing methods to the radiologic image. PMID- 4315311 TI - A case of Poland's syndrome: congenital unilateral brachysyndactyly with partial absence of the pectoralis major muscle. PMID- 4315312 TI - Pyrexia in a rural Bantu children's ward. PMID- 4315313 TI - Drugs and the mechanism of insulin secretion. PMID- 4315314 TI - Brain stem tumors of childhood and adolescence. PMID- 4315315 TI - Hemodialysis in children. PMID- 4315316 TI - Vaccine-derived poliomyelitis. PMID- 4315317 TI - [Determination of vitamins in pharmaceutic products. I. Trans-retinol (vitamin A)]. PMID- 4315318 TI - Breast cancer found on repetitive examination in mass screening. PMID- 4315319 TI - Gustatory sweating after radical neck dissection. PMID- 4315320 TI - Herniation of the facial nerve in the middle ear. PMID- 4315321 TI - [A microphysiologic analysis of the electrical activity of various types of spinal neurons in experimental tetanus]. PMID- 4315322 TI - Enlargement of mitochondrial compartment in iron and copper deficiency. PMID- 4315323 TI - Effects of prostaglandins, epinephrine and NaF on human leukocyte, platelet and liver adenyl cyclase. PMID- 4315324 TI - Aldosterone, angiotensin, and hypertension. PMID- 4315325 TI - Staging, grading and histochemistry of ovarian epithelial tumors. PMID- 4315326 TI - Subsequent second primary and metastatic cancer of the ovary. PMID- 4315327 TI - [Extrapancreatic hypoglycemic tumor associated with pancreatic nesidioblastoma]. PMID- 4315328 TI - Accelerated induction of hepatoma in rats fed N,N'2,7-fluorenylenebisacetamide by x-irradiation to the target area. PMID- 4315329 TI - [Change in the ultrastructure and function of the fibroblast under the effect of quartz dust]. PMID- 4315330 TI - [Hygienic, clinical and experimental data on the characteristics of magnesite pneumoconiosis]. PMID- 4315331 TI - The enzymehistochemical maturation of the cerebellar cortex of rats after early postnatal x-irradiation. PMID- 4315332 TI - Hereditary motor end-plate disease in the mouse: light and electron microscopic studies. PMID- 4315333 TI - [Histochemistry of the adrenal cortex: the effect of ACTH and cortisone on the rat adrenal cortex]. PMID- 4315334 TI - [Corticosteroids in complex therapy of patients with various types of tuberculosis]. PMID- 4315335 TI - [Canalicular pain syndromes in the upper extremities]. PMID- 4315336 TI - Properties of a solubilized form of the cytochrome P-450-containing mixed function oxidase of liver microsomes. PMID- 4315337 TI - The binding of antimalarial aminoquinolines to nucleic acids and polynucleotides. PMID- 4315338 TI - [Anatomo-clinical correlations in cystosarcoma phyllodes of the breast. Presentation of a case of giant fibroadenoma]. PMID- 4315339 TI - [Influence of human serum on neuromuscular transmission in mammalian muscle]. PMID- 4315340 TI - Facial paralysis. PMID- 4315341 TI - The passive immunotherapy of murine leukaemia. I. The production of antisera against leukaemic antigens. PMID- 4315342 TI - Choriocarcinoma and the HL-A2 antigen (MAC). PMID- 4315343 TI - [Morphopathology of pulmonary and extra-pulmonary neural structures associated with broncho-pulmonary cancer]. PMID- 4315344 TI - [Morphological characteristic of chemodectomas]. PMID- 4315345 TI - [Treatment of non-specific ulcerative colitis with steroid preparations]. PMID- 4315346 TI - The rate-limiting step in the adenine phosphoribosyltransferase reaction. PMID- 4315347 TI - Synthesis of 3'-5' dinucleotides with RNase T-1. PMID- 4315348 TI - Sorbitol synthesis in isolated rat pancreatic islets. PMID- 4315349 TI - Preparation and properties of the o-nitrophenyl sulfenyl derivative of ACTH: an inhibitor of the lipolytic action of the hormone. PMID- 4315350 TI - Cyclic 3',5'-nucleotide phosphodiesterase. Demonstration of an activator. PMID- 4315351 TI - A phosphoribosyl-enzyme covalent intermediate in the first enzyme of histidine biosynthesis. PMID- 4315352 TI - Oxidative phosphorylation in Thiobacillus novellus. PMID- 4315353 TI - The mechanism of 6-deoxyhexose synthesis IV. The role of pyridine nucleotide in substrate release. PMID- 4315354 TI - 32P-3',5'-cyclic AMP: a simple preparative proceduce. PMID- 4315355 TI - [Pancreatic organic hypoglycemia]. PMID- 4315356 TI - [Renin-angiotensin system in pathology]. PMID- 4315357 TI - Arginase activity in nickel sulfide-induced rat tumors. PMID- 4315359 TI - Benign mixed tumor of the trachea with seven-year follow-up. PMID- 4315358 TI - Metabolically active liver metastases treated by 5-fluorouracil hepatic artery infusion. PMID- 4315360 TI - Bronchogenic carcinoma: nitrogen mustard as a surgical adjuvant and factors influencing survival. University surgical adjuvant lung project. PMID- 4315361 TI - [Case of insulinoma]. PMID- 4315362 TI - Enzymes controlling 2,3-diphosphoglycerate in human erythrocytes. PMID- 4315363 TI - Phage-specific and host proteins in the replication of bacteriophage RNA. PMID- 4315364 TI - The pharmacology of bone. Introduction. PMID- 4315365 TI - Cyclic 3',5'-adenylic acid in bone and the mechanism of action of parathyroid hormone. PMID- 4315366 TI - Cyclic 3',5'-adenylic acid in bone and the mechanism of action of parathyroid hormone. Discussion. PMID- 4315367 TI - Nucleoproteins in regulation of gene function. PMID- 4315369 TI - [Action of lysolecithin and (omega-acyloxyalkyl)-choline phosphates on the activity of microsomal enzymes]. PMID- 4315368 TI - Gluconeogenesis, lipogenesis and the Sherringtonian metaphor. PMID- 4315370 TI - [Properties of a p-anisate-O-demethylase in cell-free extracts of Pseudomonas species]. PMID- 4315371 TI - Inhibition of peptide chain elongation in a cell-free system from yeast by pre incubation of the yeast peptidyl-translocase with diphtheria toxin and NAD. PMID- 4315372 TI - Left adrenal aldosterone producing tumor with a congenitally absent right adrenal gland. PMID- 4315373 TI - Diagnosis of renal hypertension using renal activity and renal vein pressor assay. PMID- 4315374 TI - [Pathological biochemistry of tumor bearing animals. 9. Seum glycoproteins]. PMID- 4315376 TI - [Demonstration of sorbite dehydrogenase in human erythrocytes]. PMID- 4315375 TI - [Adrenaline and noradrenaline excretion during angiotensin II infusions into the carotid artery of anesthetized dogs]. PMID- 4315378 TI - The combined treatment of glioblastoma multiforme. PMID- 4315377 TI - [Chemical changes in blood and bile in heterologous liver perfusion]. PMID- 4315379 TI - The combined treatment of malignant gliomas with various chemotherapeutics administered simultaneously. PMID- 4315380 TI - Histological investigations of brain tumours treated by combined therapy. PMID- 4315381 TI - Phasic D.C. potential shifts in the sensorimotor and visual cortices during desynchronized sleep. PMID- 4315383 TI - Psychopharmacological action of nicotinamide adenine dinucleotide. PMID- 4315382 TI - The contribution of the medial and lateral vestibular nuclei to presynaptic and postsynaptic effects produced in the lumbar cord by vestibular volleys. PMID- 4315384 TI - Amoebiasis in Cape Town children. PMID- 4315385 TI - [Experimental studies on survival of autogenic adrenal grafts]. PMID- 4315386 TI - Physiologic development of impulse conduction in embryonic cardiac tissue. PMID- 4315387 TI - A twenty-five year experience with soft tissue sarcomas. PMID- 4315388 TI - Problems in diagnosis and treatment in renal transplantation. PMID- 4315389 TI - [Viral diseases of the nervous system]. PMID- 4315390 TI - [Cellular alterations proper to viral infections]. PMID- 4315391 TI - [Anatomy and classification of viruses]. PMID- 4315392 TI - Adenyl cyclase and myocardial contractility. PMID- 4315393 TI - [Testicular feminization and androblastoma]. PMID- 4315394 TI - Analysis of axon-sheath relations during early Wallerian degeneration. PMID- 4315396 TI - The effects of adrenocorticotrophic hormone on adrenal weight and adrenal ascorbic acid in the normal and bursectomized fowll. PMID- 4315395 TI - Testing the hypothalamic-pituitary-adrenal axis. PMID- 4315397 TI - Effect of trypsin on mitochondrial and microsomal enzymes. PMID- 4315398 TI - Studies in vitro on amino acid incorporation into purified components of rat liver mitochondria. PMID- 4315399 TI - An electroencephalographic study of behavioral rapid eye movement states in the human newborn. PMID- 4315401 TI - Crisis intervention with geriatric hospitalized patients. PMID- 4315400 TI - Small molecule-macromolecular interactions as studied by optical rotatory dispersion--circular dichroism. PMID- 4315402 TI - Psychiatric drugs & trends. Chemical used to treat tumor arouses woman; scientists begin testing it on animals. PMID- 4315404 TI - Effect of alpha-methyl tyrosine on content and subcellular distribution of norepinephrine in rat heart and brain. PMID- 4315403 TI - Proteins spcified by herpes simplex virus. II. Viral glycoprotins associated with cellular membranes. AB - Membranes prepared from HEp-2 cells infected with herpes simplex virus and free from soluble proteins, virus, ribosomes, and other cellular constituents were solubilized and subjected to electrophoresis on acrylamide gels. The electropherograms showed the following. (i) The synthesis of host proteins and glycoproteins ceases after infection. However, the spectrum of host proteins in membranes remains unaltered. (ii) Between 4 and 22 hr postinfection, at least four glycoproteins are synthesized and bound to the smooth cytoplasmic membranes. On electrophoresis, these glycoproteins form two major and two minor bands in the gel and migrate with proteins ranging from 50,000 to 100,000 daltons in molecular weight. (iii) The same glycoproteins are present in all membranes fractionated by density and in partially purified virus. The implications of the data are discussed. PMID- 4315405 TI - Temporal and quantitative aspects of continuous superfusion of rat adrenals. PMID- 4315406 TI - Involvement--a way of nursing. PMID- 4315408 TI - Hydrocephalus in mice inoculated neonatally by the oronasal route with reovirus type 1. AB - Mice inoculated neonatally by the oronasal route with reovirus type 1 or 2 developed typical acute disease. Fifteen percent of the mice recovered from the acute infection. No further disease was noted in mice infected with reovirus 2, but 9 percent of the survivors of reovirus I infections developed hydrocephalus at a mean time of 109 days after inoculation. Infectious virus could not be isolated from hydrocephalic mice. PMID- 4315409 TI - Studies of the pH inactivation of three variants of Mengo encephalomyelitis virus. PMID- 4315410 TI - Granular-cell myoblastoma of the tongue. PMID- 4315411 TI - [Cancerostatic effect of alkylating compounds in relation to glycolytic activity of tumor cells in vivo]. PMID- 4315412 TI - Multiple histiocytomas. Report of a case. PMID- 4315413 TI - Lentiginosis profusa in daughter and mother: multiple granular cell "myoblastomas" in the former. PMID- 4315414 TI - Oxidative deficiencies and some ultrastructural features of acridine-induced male strains of Allomyces arbusculus. PMID- 4315415 TI - Purification and some properties of two hemorrhagic principles (HR2a and HR2b) in the venom of Trimeresurus flavoviridis; complete separation of the principles from proteolytic activity. PMID- 4315416 TI - [Chromosomal and cytochemical findings in osteomyelosclerosis]. PMID- 4315417 TI - Distribution of adrenergic nerves and changes in neuromuscular transmission in the mouse vas deferens during postnatal development. PMID- 4315418 TI - [A new inhibitor, fuscin, in the study of animal and yeast mitochondria respiratory chains]. PMID- 4315419 TI - The nucleotide sequences of tyrosine transfer RNAs of Escherichia coli. PMID- 4315420 TI - [Histogenetic considerations on a case of extramammary Paget's disease]. PMID- 4315421 TI - [Clinico-statistical data on 1000 pre-epitheliomatosic lesions and epitheliomatosis]. PMID- 4315422 TI - Disturbances in fat digestion induced by acidic jejunal pH due to gastric hypersecretion in man. PMID- 4315423 TI - [Metastatic glomus tumor of the middle ear]. PMID- 4315424 TI - Terramycin powder with polymixin B in office surgery. PMID- 4315425 TI - [Specific therapy of virus diseases]. PMID- 4315426 TI - [Mixed tumors of the salivary glands. Pleomorphic adenomas]. PMID- 4315427 TI - Stimulation of thyroid adenyl cyclase activity and cyclic adenosine 3',5' monophosphate by long-acting thyroid stimulator. PMID- 4315428 TI - Tumor hypoglycemia: a heterogeneous disorder. PMID- 4315429 TI - Correlation of effects of thyrotropin, prostaglandins and ions on glucose oxidation, cyclic-AMP, and colloid droplet formation in dog thyroid slices. PMID- 4315430 TI - [A case of hepatoblastoma in a 12-month-old girl with postoperative survival of over 3 years]. PMID- 4315431 TI - [Experimental production of pneumatosis cystoides intestinalis of an infantile type]. PMID- 4315432 TI - [Solitary osseous metastasis during mixed tumor of the parotid gland]. PMID- 4315433 TI - [Iodized oil diagnosis of the posterior cranial fossa]. PMID- 4315434 TI - [Ventriculography with positive contrast media in expansive diseases of the median line and in the area of the posterior cranial fossa]. PMID- 4315435 TI - [Seriographic studies with central iodine-ventriculography in tumors of the posterior cranial fossa]. PMID- 4315436 TI - Intracranial self-stimulation and wakefulness: effect of manipulating ambient brain catecholamines. AB - Rats were given disulfiram, an inhibitor of norepinephrine biosynthesis, to see if norepinephrine is a transmitter for motivation in electrical stimulation of the brain. Animals given the drug paused in bar pressing, appearing asleep or sedated; if replaced on the bar, they always resumed pressing at normal rates. The decrease in bar pressing may result from a direct or indirect effect of the drug on wakefulness rather than on reward. PMID- 4315437 TI - [Malignant adenomatosis of the lung]. PMID- 4315438 TI - [Pulmonary adenomatosis]. PMID- 4315439 TI - [Adrenal cortex function in patients with chronic pneumonia]. PMID- 4315440 TI - Mammary tumor virus associated antigens on the membrane of infected mouse spleen cells. PMID- 4315441 TI - Surface antigen(s) of SV40-transformed tumor cells. PMID- 4315442 TI - [Unspecific phosphodiesterases in 2 strains of Proteus mirabilis]. PMID- 4315443 TI - The pathogenic actions of exotoxins. PMID- 4315444 TI - [Reciprocal dissociativity of DNA synthesis and giant cell formation in Herpesvirus hominis caused by cytosine arabinoside and compound 48-80]. PMID- 4315445 TI - [Electron microscopic and virological studies of virus production in Rous sarcomas]. PMID- 4315446 TI - [Modification of the pyrogenic effect of influenza viruses with various biologically active compounds]. PMID- 4315447 TI - [Activated sepharose as immunoadsorbent in the foot-and-mouth disease virus system]. PMID- 4315448 TI - [Characterization of nucleases of Staphylococcus aureus]. PMID- 4315449 TI - Hypokalemia with normal blood pressure, aldosterone and renin levels secondary to a renal or adrenal tumor. PMID- 4315450 TI - Surgery and facial nerve grafting in malignant parotid disease. PMID- 4315451 TI - Emphysematous cholecystitis: An unusual form of presentation. PMID- 4315452 TI - Occipital and geniculate potentials related to eye movements in the unanaesthetized cat. PMID- 4315453 TI - Spinal cord function in postischemic rigidity in the rat. PMID- 4315454 TI - "Functional isolation" as a general mode of nervous activity. PMID- 4315455 TI - The inhibitory effect of climbing fiber activation on cerebellar purkinje cells. PMID- 4315456 TI - Recurrent excitatory pathways of anterior commissure and mitral cell axons in the olfactory bulb. PMID- 4315457 TI - [Radioimmunologic determination of rat LH , EITHER IN A HYPOPHYSEAL INCUBATION MEDIUM OR IN PLASMA, FOLLOWING THE ADMINISTRATION OF LRF and cyclic AMP]. PMID- 4315458 TI - [Obtaining a specific antigenic extract from Entamoeba histolytica kept in mixed culture]. PMID- 4315459 TI - [Effect of thiocyanate and perchlorate on free thyroxine fraction]. PMID- 4315460 TI - Selective effects of anti-macrophage serum, silica and anti-lymphocyte serum on pathogenesis of herpes virus infection of young adult mice. PMID- 4315461 TI - Macrophages and age-dependent resistance to Herpes simplex virus in mice. PMID- 4315462 TI - [On the correlation between angiotensin II and the glomerular area of the adrenal gland]. PMID- 4315463 TI - [Functioning of the adrenal cortex and protein composition of blood serum in dogs with Eck-Pavlov venous anastomosis]. PMID- 4315464 TI - Comparison of survival curves, 1956 versus 1962, in children with Wilms' tumor and neuroblastoma. Report of the Subcommittee on Childhood Solid Tumors, Solid Tumor Task Force, National Cancer Institute. PMID- 4315466 TI - [Immunofluorescent determination in tissue cultures of adenovirus isolated from swine]. PMID- 4315465 TI - [The blood phosphatase-bilirubin ratio in the differential diagnosis of icterus]. PMID- 4315467 TI - [Culturing foot-and-mouth disease virus in VNK-21 cells in rotating vessels]. PMID- 4315468 TI - [Purifying foot-and-mouth disease virus for electron microscopy]. PMID- 4315469 TI - [Seroprotection reaction in suckling mice for identification of foot-and-mouth disease virus strains]. PMID- 4315470 TI - [Disinfection of milk contaminated with foot-and-mouth disease virus at dairy plants]. PMID- 4315472 TI - [Hydrazine- and hydroxylamine-derivatives of phosphonous acids]. PMID- 4315471 TI - [Marchionini memorial lecture. The sick leg from the viewpoint of dermatology]. PMID- 4315473 TI - [Effect of Aerosil and Aerosil R 972 on the water absorption ability of powdered raw materials]. PMID- 4315474 TI - [Preliminary study of crude collagenase extracted from the 1st stage larva of Hypoderma lineatum (de Villers)]. PMID- 4315475 TI - Experimental study of the blood-brain barrier in the frozen cerebral cortex. PMID- 4315477 TI - Synovial sarcoma with osseous metaplasia at an uncommon site. PMID- 4315476 TI - Biochemical studies on the host-liver and hepatocarcinoma induced by N-2 fluorenyl-acetamide (N-2FAA). PMID- 4315478 TI - Cushing's disease without hypercortisolism. PMID- 4315479 TI - "Cure" of ectopic ACTH syndrome secondary to adrenocarcinoma of the lung. PMID- 4315480 TI - Effect of testosterone on growth hormone secretion in patients with anorchia and delayed puberty. PMID- 4315481 TI - Specific estrogen binding by the cytoplasm fof human breast carcinoma. PMID- 4315482 TI - Pituitary-adrenal function in ten patients receiving medroxyprogesterone acetate for true precocious puberty. PMID- 4315483 TI - XO-XX-XXX mosaicism with possible congenital adrenal hyperplasia. PMID- 4315484 TI - Cortisol is secreted episodically in Cushing's syndrome. PMID- 4315485 TI - Unusual type of congenital adrenal hyperplasia probably due to deficiency of 3 beta-hydroxysteroid dehydrogenase. Case report of a surviving girl and steroid studies. PMID- 4315487 TI - Fusion of unfertilized mouse eggs with somatic cells. PMID- 4315486 TI - Extra-adrenal action of adrenocorticotropin on cortisol metabolism. PMID- 4315488 TI - Herpesvirus infection and central nervous system malformations. PMID- 4315489 TI - Herpesvirus infection and central nervous system malformations. PMID- 4315490 TI - Cylindroma. PMID- 4315491 TI - Effect of protein synthesis inhibitor on accumulation of fructose-1, 6 diphosphate in irradiated rat thymocytes. PMID- 4315492 TI - [Adrenocortical functions in cancer patients-ectopic ACTH syndrome]. PMID- 4315493 TI - Studies on swine enteroviruses. Japanese 6th serotype and relationship between heat susceptibility and ctyopathic effects. PMID- 4315494 TI - Acid phosphatase in Clostridium perfringens. A new rapid and simple identification method. PMID- 4315495 TI - In vitro transformation of hamster cells by infectious canine hepatitis virus. PMID- 4315496 TI - Mental health in and out of public health. PMID- 4315497 TI - Excretion of murine leukaemia virus. PMID- 4315498 TI - Synthesis of herpes simplex virus structural proteins in arginine deprived cells. PMID- 4315500 TI - Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 25-1970. PMID- 4315499 TI - [Information furnished by extemporaneous histopathological examination in the course of neurosurgical intervention]. PMID- 4315501 TI - [Electropolygraphic aspects of sleep in patients with parkinsonism]. PMID- 4315502 TI - Renal-portal venous shunt for the correction of pressor-induced hypertension. PMID- 4315503 TI - Experimental coarctation of the aorta: effects of diminished pulse pressure on renin activity, juxtaglomerular granulation, and angiotensin sensitivity. PMID- 4315504 TI - Effect of macro- and micropulmonary emboli on airway resistance and lung compliance. PMID- 4315505 TI - Influence of adrenocorticotropic hormone on the rate of gastric mucosal cell turnover. PMID- 4315506 TI - Alterations in membrane transport produced by diarrheogenic non-beta islet cell tumors of the pancreas. PMID- 4315507 TI - Energy metabolism of the glioblastoma: chemotherapeutic implications. PMID- 4315508 TI - Distribution of cell doubling times in in vivo human cerebral tumors. PMID- 4315509 TI - Inhibition by antiandrogens of the prostatic growth stimulated by adrenal androgens and pituitary prolactin in castrate rats. PMID- 4315510 TI - Prevention by topical antibiotics of experimental wound infections produced by enteric bacteria. PMID- 4315511 TI - Mechanism of action of glucagon-induced hypocalcemia. PMID- 4315512 TI - Electron microscopic observations of sural nerve in familial opticoacoustic nerve degeneration with polyneuropathy. PMID- 4315513 TI - [Ultrastructure of unmyelinated(Remak) nerve fibers in isoniazid neuropathy]. PMID- 4315514 TI - Fine-needle aspiration biopsy of human liver for enzymatic diagnosis of glycogen storage disease and gargoylism. PMID- 4315515 TI - Cytomegalovirus infections in different groups of paediatric patients. PMID- 4315516 TI - Encephaloningitis in children associated with an adenovirus type 7 epidemic. PMID- 4315517 TI - Re-examination of encephalitic brains known to contain intranuclear inclusion bodies: electron-microscopic observations following prolonged fixation in formalin. PMID- 4315518 TI - Health-screening for occupational skin diseases in uilding workers. PMID- 4315519 TI - [Session on industrial dermatology. 2d International Symposium "Industrial Hygiene and Protection in the Construction Industry". (Eisenach 15-19 Oct 1968)]. PMID- 4315520 TI - An electrophysiological study of the cerebellar projections to the nucleus ventralis lateralis thalami in the cat. 2. Nucleus lateralis. PMID- 4315521 TI - Sleep stage relations within the sleep cycles of the cat. PMID- 4315522 TI - [Scintigraphy in lung cancer diagnostics]. PMID- 4315523 TI - On the origin of adenosine triphosphate in chromaffin granules. PMID- 4315524 TI - Studies on the biochemical characterization of human ceruloplasmin. PMID- 4315525 TI - Significance of cyclic AMP in the regulation of exocrine pancreas secretion. PMID- 4315526 TI - Failure of the D-analog of angiotensin II-amide [D-asp (NH2)-D-arg-D-val-D-try-D val-D-his-D-prol-D-phe (OH)] to influence water diuresis in the rat. PMID- 4315527 TI - Influence of germ-free status on the excretion of simple phenols of possible significance in tumour promotion. PMID- 4315528 TI - Relation between carcinogenicity and metabolic reduction of 4-nitroquinoline 1 oxide derivatives. PMID- 4315529 TI - Suppression of antibody formation against Sendai virus in the SV40 and adenovirus 16 infected hamsters. PMID- 4315530 TI - Volumetric determination of amino acid and peptide hydrazides. PMID- 4315531 TI - Possible requirement of adenosine triphosphate for the rejoining of x-ray-induced breaks in the DNA of Ehrlich ascites-tumour cells. PMID- 4315532 TI - Radiation-induced radicals in thymidine single crystals at 77 degrees K. PMID- 4315533 TI - [Influence of antibiotics on the pyocyaninproduction by Pseudomon auginosa]. PMID- 4315534 TI - [Therapy of hepatoma]. PMID- 4315535 TI - [Studies on the adrenocortical functions in patients with nephrotic syndrome during administration of ACTH-Z]. PMID- 4315536 TI - Alcoholic neuropathy. An electrophysiological and histological study. PMID- 4315537 TI - [Multiple neuritis]. PMID- 4315538 TI - [Neurologic symptoms in malignant tumors--the cerebellum, spinal cord and peripheral nerves]. PMID- 4315540 TI - [Differential diagnosis of neuropathy and myopathy]. PMID- 4315539 TI - [Neurologic symptoms in malignant tumors. Muscles and the myoneural junction]. PMID- 4315541 TI - [Neuropathy due to drug therapy]. PMID- 4315542 TI - [Insulinoma]. PMID- 4315543 TI - [Chemodectoma of the thyroid gland]. PMID- 4315544 TI - [Use of hormones in surgery]. PMID- 4315545 TI - [Pathological study of PML, with special reference to the significance of PML virion]. PMID- 4315546 TI - [Case of recurrent multiple cranial neuropathy caused by sarcoidosis]. PMID- 4315547 TI - Making proteins in higher cells. PMID- 4315548 TI - Cytoplasmic methionine transfer RNAs from eukaryotes. PMID- 4315549 TI - Rat embryo cells in complement fixation tests for murine leukemia virus. PMID- 4315550 TI - Serological studies with EB virus in infectious lymphocytosis. PMID- 4315551 TI - Histones and gene control. PMID- 4315552 TI - Evidence for epitaxy in the formation of collagen and apatite. PMID- 4315553 TI - Stimulation of glycerol production in fat cells by cholera toxin. PMID- 4315554 TI - [Angiographic diagnosis of insuloma. Discussion of a case]. PMID- 4315555 TI - The medial tarsal tunnel syndrome. Entrapment neuropathy of the plantar nerves. PMID- 4315556 TI - [Direct and indirect effect of irradiation on the transmission of the stimulus in the upper neck sympathetic ganglion of cats]. PMID- 4315557 TI - Oxygen cost of sodium reabsorption in proximal and distal parts of the nephron. PMID- 4315558 TI - Serum triglyceride values in healthy adults. PMID- 4315559 TI - A non-extraction atomic absorption method for the determination of lead in blood. PMID- 4315560 TI - Cardiac response to increased aortic pressure. Changes in output and left ventricular pressure pattern at various levels of inotropy. PMID- 4315561 TI - [Transformation with virus SV40 of renal cells of the adult golden hamster (Mesocricetus auratus) cultured in vitro]. PMID- 4315562 TI - [Primary hepatic cancer in childhood]. PMID- 4315563 TI - [The sensitivity of B. pertussis to antibiotics. Examination of 122 patients' strains of B. pertussis]. PMID- 4315564 TI - [Etiology of acute respiratory infections in infants. Virological and serological studies]. PMID- 4315565 TI - Suppression of impulse transmission in the cat's dorsal horn by inhalation anesthetics. PMID- 4315566 TI - [Studies on the pathophysiological principles of brain scintigraphy using Tc99m pertechnate]. PMID- 4315567 TI - Syndromes of infectious mononucleosis. PMID- 4315568 TI - [Enzyme activity in irradiated skin. Cytochrome oxidase and monoamine oxidase]. PMID- 4315569 TI - [Angiofibroma in adolescents]. PMID- 4315570 TI - [Complex genital tumor in women: Mulleroblastoma]. PMID- 4315571 TI - [Use of conjugated estrogens in diabetic retinopathy]. PMID- 4315572 TI - [Results of angiotensin infusion test in renovascular hypertension and other forms of hypertension]. PMID- 4315573 TI - [Virostatic effect and clinical use of 1-allyl-3,5-diethyl-6-chlorouracil]. PMID- 4315574 TI - [Clinical trial of a powder spray associating terramycin and polymyxin B in the local treatment of burn surfaces and some traumatic wounds. (20 cases)]. PMID- 4315575 TI - [A case of Biermer's anemia with liver cirrhosis (development followed for 14 years, death due to hepatocarcinoma)]. PMID- 4315576 TI - [Acroparesthesias]. PMID- 4315577 TI - [Effects of 2 hypnotics (Nitrazepam and Dormin) on self-rated and physiologically recorded sleep in subjects with and without anxiety symptoms]. PMID- 4315578 TI - [Spontaneous, peripheral and central nystagmus]. PMID- 4315579 TI - [Effect of neonatal thymectomy on antibody formation and experimental infections in mice]. PMID- 4315580 TI - [Clinical aspects and diagnosis of para-influenzal infections in children]. PMID- 4315581 TI - [Prognostic value of certain blood indices in rickets]. PMID- 4315582 TI - Bronchial adenomas. PMID- 4315583 TI - Hepatoblastoma and hepatocarcinoma in infancy and childhood. Report on the pathology of eight cases from the University Hospital, Copenhagen. PMID- 4315584 TI - Effects of ACTH on membranous whorls in the adrenal glands of the Mongolian gerbil. PMID- 4315586 TI - Cornea and sclera. PMID- 4315585 TI - Generation of reducing power in chemosynthesis. VI. Energy-linked reactions in the chemoautotroph, Thiobacillus neapolitanus. PMID- 4315587 TI - Spin label studies of oriented phospholipids: egg lecithin. PMID- 4315588 TI - The effect of ACTH on the sloughing frequency of normal and thyroidectomized Anolis carolinensis (Iguanidae, Lactertilia). PMID- 4315589 TI - Demonstration of IgM cytomegalovirus-antibodies as an aid to early diagnosis in adults. PMID- 4315590 TI - Effects of glucagon on serum calcium in the rat and on bone resorption in tissue culture. PMID- 4315591 TI - Response of hepatic glucokinase and glucose-6-phosphatase activities in juvenile and adult hyperthyroid mice. PMID- 4315592 TI - Effects of dibutryl cyclic-3',5'-AMP and other agents upon luteinization of porcine granulosa cells in culture. PMID- 4315594 TI - Studies on the subcellular localization of corticotrophin releasing factor (CRF) and vasopressin in the median eminence of the rat. PMID- 4315595 TI - Direct inhibitory effect of adenosine monophosphates on Na plus-K plus-dependent ATPase prepared from human gastric mucosa. PMID- 4315593 TI - Lipolytic substances in bovine thyroid, parotid and pineal glands. PMID- 4315596 TI - Thyroid scanning in the diagnosis of thyroid neoplasia in two dogs. PMID- 4315597 TI - Compositional variations in the common pentanucleotide from transfer ribonucleic acids of Escherichia coli. PMID- 4315598 TI - The anthranilate synthetase-anthranilate 5-phosphoribosylpyrophosphate phosphoribosyltransferase aggregate. Purification of the aggregate and regulatory properties of anthranilate synthetase. PMID- 4315599 TI - ESR study of an irradiated crystal of L-alanine: two new proton-deuteron exchange reactions. PMID- 4315600 TI - Certain bacteria, some of medical interest, associated with the slug Limax maximus. PMID- 4315601 TI - Melanotic lesions in two insect species. Drosophila melanogaster (Diptera) and Melanoplus sanguinipes (Orthoptera). PMID- 4315602 TI - Electron spin resonance study of deamination of amino acids by hydrated electrons. PMID- 4315603 TI - An integrated rate equation for determining initial velocities. PMID- 4315604 TI - Labile coat: reason for noninfectious cell-free varicella-zoster virus in culture. AB - Experiments designed to determine why cell-free varicella-zoster virus replicated in cell culture is noninfectious were performed. Electron micrographs in which varicella-zoster virus (a herpesvirus) was compared to herpes simplex virus in primary human amnion cell cultures showed that the viruses were morphologically indistinguishable inside the nucleus. However, extranuclear varicella-zoster viruses were distinguished from herpes simplex virus by the presence of pleomorphism, incomplete coats, and a resultant loss of central dense cores. This result indicates that varicella-zoster virus possesses a labile coat which is degraded outside the nucleus. It is suggested that the labile coat is a principal reason for the lack of cell-free infectious virus in this system. PMID- 4315605 TI - Viral inactivation by disulfide bond reducing agents. PMID- 4315606 TI - Varicella arthritis. PMID- 4315607 TI - [Case of cholangioma caused by injection of thorotrat]. PMID- 4315608 TI - [Anesthesia and the cardiovascular system. II. The peripheral circulation]. PMID- 4315609 TI - [Chemical and physiochemical behavior of colloidal silicic acid aerosil and its reciprocal effect with anorganic and organic substances]. PMID- 4315610 TI - [Can abnormal water be demonstrated SPECTROSCOPICALLY IN CAPILLARIES?]. PMID- 4315611 TI - Comparison of Bender-Gestalt reproductions patients with peripheral neuropathy. PMID- 4315612 TI - Neutralization of sensitized virus by purified components of complement. AB - Herpes simplex virus which had been sensitized with immunoglobulin M antibody was neutralized by serum deficient in the fifth and sixth components of complement (C) but not by serum deficient in the fourth component C (C4). The sequential addition of the functionally purified components of C showed that the activated first component of C (C1[unk]) failed to neutralize sensitized virus. However, in the presence of an optimal concentration of C1[unk], the addition of C4 resulted in neutralization. The amount of virus neutralized was dependent upon the concentration of immunoglobulin M used to sensitize the virus and the concentration of C1[unk] and C4. The addition of the second component of C (C2) to reaction mixtures containing an optimal concentration of C1[unk] and a limiting concentration of C4 resulted in increased neutralization and the amount of virus neutralized was dependent upon the concentration of C2. The addition of the third component of C (C3) to reaction mixtures containing an optimal concentration of C1[unk] and limiting concentrations of C4 and C2 also resulted in increased neutralization and the amount of virus neutralized was dependent upon the concentration of C3. PMID- 4315613 TI - Isolation of double lysogens from 3T3 cells transformed by plaque morphology mutants of SV40. AB - Simian virus 40 (SV40) rescued from 3T3 lines transformed independently by fuzzy plaque strain, SV40 (mKS-U4), and small-clear plaque strain, SV40 (mKS-U88), resembled the virus used to initiate the transformation. When a mixture of the two viruses was used for transformation, both plaque types could be rescued. Two clonal lines, after fusion with CV-1 cells, yielded both plaque types of infectious centers, and a third clonal line, 3T3(4-88)G-1, yielded fuzzy and small-clear plaque types of infectious centers plus large-clear infectious centers resembling "wild-type" SV40 clone 307L. Two secondary and 14 tertiary clones of 3T3(4-88)G-1 were isolated, all of which yielded fuzzy plaque type and clear infectious centers after fusion with CV-1 cells. When these infectious centers were picked and replated on CV-1 cells, the fuzzy and small-clear plaque types of SV40, as well as a large-clear plaque type resembling parental SV40, were isolated. PMID- 4315614 TI - The relationship between glucocorticoid binding and tyrosine aminotransferase induction in hepatoma tissue culture cells. AB - Glucocorticoid receptors with many properties suggesting their involvement in the hormonal induction of tyrosine aminotransferase have been detected in rat hepatoma tissue culture cells. These "specific receptors" approach saturation as the steroid concentrations required for maximal induction are reached. Inducer analogs influence cortisol binding to the specific receptors in direct relation to their influence on cortisol induction. The inducer association with and dissociation from specific receptors are rapid enough to account for the kinetics of induction and deinduction. Chromatographic studies suggest the specific receptors bind unaltered dexamethasone and cortisol. "Nonspecific" association of steroids with the cells also occurs and can be distinguished from specific binding. PMID- 4315615 TI - ACTH receptors in the adrenal: specific binding of ACTH-125I and its relation to adenyl cyclase. AB - Pure monoiodo ACTH-(125)I was prepared that was biologically active and free of unlabeled ACTH. Extracts of adrenal cortex that contained ACTH-sensitive adenyl cyclase, bound ACTH-(125)I; extracts that lacked the ACTH-sensitive cyclase did not bind ACTH-(125)I. Unlabeled ACTH inhibited the binding of ACTH-(125)I. Five ACTH derivatives which varied widely in biological activity were tested. All inhibited the binding of ACTH-(125)I in direct proportion to their biological activity. Albumin, insulin, and four unrelated iodinated hormones were inert. The addition of excess hormone or acetic acid produced rapid dissociation of bound ACTH-(125)I. This study demonstrates directly the binding of ACTH to its biologically significant site. PMID- 4315617 TI - [Maturation indices in the surveillance of scoliosis]. PMID- 4315616 TI - Reaction sites of rotenone, piericidin A, and amytal in relation to the nonheme iron components of NADH dehydrogenase. AB - The locus of inhibition of nicotinamide adenine dinucleotide, reduced form (NADH) oxidation in mitochondria by rotenone, piercidin A, and barbiturates is considered in the light of available information. Most lines of evidence indicate that the point of inhibition is on the O(2) side of NADH dehydrogenase. Kinetic experiments on the substrate-induced appearance of the electron paramagnetic resonance signal at g = 1.94 in membrane preparations (ETP) reveal that these inhibitors do not interfere with the reduction of the electron paramagnetic resonance detectable iron by NADH. Our spectrophotometric studies on complex I give no evidence for absorbance differences between untreated and rotenone or piericidin inhibited preparations, which can be attributed to nonheme iron. Whatever changes were observed appear to be due to cytochromes. These experiments, therefore, do not support the idea that in inhibited preparations electron transport is interrupted between the flavin and nonheme iron components of NADH dehydrogenase. The specific binding of rotenone and piericidin seems to involve both lipid and protein. The possibility that NADH dehydrogenase participates in the binding is suggested by the apparent stoichiometric relation between specific binding site titer and NADH dehydrogenase content and the profound effect of mersalyl inhibition of the enzyme on piericidin binding capacity.ETP, electron transport particle. PMID- 4315618 TI - [Endocardial fibroelastosis. 20 cases]. PMID- 4315619 TI - [Aneurysms of the hepatic artery. A case with multiple localizations]. PMID- 4315620 TI - [Cerebral tumors revealed by an acute meningeal syndrome: subarachnoid hemorrhage or aseptic meningitis]. PMID- 4315621 TI - [Abduction apparatus for the follow-up treatment of congenital hip dislocation]. PMID- 4315622 TI - The association of genital herpesvirus with cervical atypia and carcinoma in situ. PMID- 4315623 TI - Antibodies to Herpesvirus hominis types 1 and 2 in humans. I. Patients with genital herpetic infections. PMID- 4315624 TI - Antibodies to Herpesvirus hominis types 1 and 2 in humans. II. Women with cervical cancer. PMID- 4315625 TI - Seroepidemiologic studies of coronavirus infection in adults and children. PMID- 4315626 TI - Pathogenic potential of fungal insecticides. PMID- 4315627 TI - Hypertension in young females receiving anovulatory steroids. PMID- 4315628 TI - Some properties of carrier strains of foot-and-mouth disease virus. PMID- 4315629 TI - Observations on the growth and development of bluetongue, nairobi sheep disease and Rift Valley Fever viruses by fluorescent antibody technique and titration in a tissue culture system. PMID- 4315630 TI - Interference between bovine parainfluenza 3 virus and a street strain of rabies virus in rabbits. PMID- 4315631 TI - Cytomegalovirus antibody assay by platelet aggregation. PMID- 4315632 TI - The possible value of certain cells for the propagation of respiratory viruses. PMID- 4315633 TI - Partial purification of a soluble (Na+ + K+)--dependent ATPase from rabbit kidney. PMID- 4315634 TI - Carbohydrate composition of the plasma membranes of rat ascites hepatoma. PMID- 4315635 TI - [Research the overseas Pasteur Institutes]. PMID- 4315636 TI - Serological response of the EBV antibodies in pediatric cases of infectious mononucleosis and in their contacts. AB - The EBV antibodies were measured in 378 sera from a group of 129 pediatric and older cases of infectious mononucleosis and from 117 family and social contacts. Cases of infectious mononucleosis with only one exception were EBV seropositive in acute and/or convalescent sera. Fourteen cases, however, from whom no convalescent serum was available were EBV seronegative. A rise in EBV antibodies of two dilutions or more was demonstrated in 15 of the 129 cases. The prevalence of these antibodies in contacts reached 50 to 70% in each of four age groups. A significant antibody rise was encountered in only four cases, one of whom was found to have infectious mononucleosis simultaneously with the index case and one after an interdisease period of 10 months. The infectivity of the EB virus (and of infectious mononucleosis if causally related) and its horizontal transmission seem to be as low in nature as they appear to be experimentally in the laboratory. PMID- 4315637 TI - Changes in interscapular brown adipose tissue of the rat during perinatal and early postnatal development and after cold acclimation. II. Mitochondrial changes. PMID- 4315638 TI - ACTH and protein synthesis in a transplantable ACTH-secreting tumor. Evidence for the absence of MSH. PMID- 4315639 TI - Pathways at the hypothalamic level through which traumatic stress activates ACTH secretion. PMID- 4315640 TI - The effect of palitantin, a metabolite of Penicillium frequentans on Leishmania brasiliensis. PMID- 4315641 TI - Late complications of burns of the hand in children and their treatment. PMID- 4315642 TI - Effects of the infectious bovine rhinotracheitis virus on the central nervous system of cattle. PMID- 4315643 TI - Biosynthesis of uridine diphosphate D-xylose. IV. Mechanism of action of uridine diphosphoglucuronate carboxy-lyase. PMID- 4315644 TI - Role of enzyme-enzyme interactions in the regulation of gluconeogenesis. Effect of fatty acids, tricarboxylic acid cycle intermediates, and dinitrophenol on the rate of inactivation on D-frucose, 1,6-diphosphatase by kidney mitochondria. PMID- 4315645 TI - Hepatic microsomal ethanol-oxidizing system. In vitro characteristics and adaptive properties in vivo. PMID- 4315646 TI - Effect of phenazine methosulfate on lipogenesis. PMID- 4315647 TI - Specific acylation of the guanine residues of ribonucleic acid. PMID- 4315649 TI - Differential effects of three tricyclic antidepressants on sleep and REM sleep in the rat. PMID- 4315648 TI - Metabolic patterns of Dirofilaria immitis microfilariae in vitro. PMID- 4315650 TI - Potassium reversible inhibition of leukotaxis by ouabain. PMID- 4315651 TI - [Attempted visualization of lymphatic drainage of the uterus in vivo]. PMID- 4315652 TI - Molecular weight and chain length of rabbit reticulocyte rRNA. PMID- 4315653 TI - Enzymatic binding of valine to the 3' end of TYMV-RNA. PMID- 4315654 TI - Evidence against a presynaptic action of acetylcholine during ganglionic transmission. PMID- 4315655 TI - [Osteomalacia, chronic pancreatitis and the blind loop syndrome]. PMID- 4315656 TI - Immune virolysis: effect of antibody and complement on C-type RNA virus. AB - In the presence of envelope antibody and complement, the AKR strain of mouse leukemia virus was lysed, with the result that (i) the viral nucleic acid became susceptible to ribonuclease digestion and (ii) the internal group-specific antigen of the virus was released. The internal localization of the group specific antigen is confirmed, the evidence being based on the failure of group specific antibody to lyse virus in the presence of complement. PMID- 4315657 TI - [Methods of preparation of small or delicate silica structures for electron and light microscopy, especially of diatoms or with small amounts of material]. PMID- 4315658 TI - [The role of adrenoreactive structures in conduction of a signal in the retina of frogs]. PMID- 4315659 TI - Effects of intravenous and intra-arterial procaine and lidocaine on neuromuscular transmission in man. PMID- 4315660 TI - Involvement of peripheral nerves in radical neck dissection. PMID- 4315661 TI - Surgical approach to insulinomas. PMID- 4315662 TI - Angiofibroma clinically indistinguishable from carotid body tumor. A possible embryologic relationship. PMID- 4315663 TI - [A study of the arginine desimidase system in toxigenic and weak-toxigenic strains of Clostridium perfringens type A]. PMID- 4315664 TI - [The connection between ribonucleoprotein and ribosomes]. PMID- 4315665 TI - [The effects of some stress factors on the digestive function of the intestinal epithelium]. PMID- 4315666 TI - [Study of the mutagenic activity of polyoma virus and the modificational mechanism in oncogenesis]. PMID- 4315668 TI - Hospital social work. PMID- 4315667 TI - [Radiation effects on the permeability of thymocyte nuclear membranes]. PMID- 4315669 TI - Clinically unrecognized, silent renal-cell carcinoma in elderly cancer patients. PMID- 4315670 TI - [Elimination of suppression of longitudinal growth caused by betamethasone administration after switching to ACTH in bronchial asthma]. PMID- 4315671 TI - [The positive inotropic effect of catecholamines]. PMID- 4315672 TI - Etiology of "idiopathic" intussusception in infants. PMID- 4315673 TI - [Innervation and motility of the stomach]. PMID- 4315674 TI - [Cysto-sarcoma phyllodes]. PMID- 4315675 TI - Incorporation of H-uridine into the adrenal cortex of mice after stimulation and inhibition. An autoradiographic study. PMID- 4315676 TI - Experimentally induced changes in plasma angiotensinogen and plasma renin. Studies on normal, nephrectomized, ureterligated, hypoxic, partially corticectomized or medullectomized and renal or spontaneously hypertensive rats. PMID- 4315677 TI - Effect of anti-angiotensin II on blood pressure and sensitivity to angiotensin and renin. Studies on normal, nephrectomized, ureterligated, continuously angiotensin infused, and renal hypertensive rats. PMID- 4315678 TI - A rapid semidirect method for the estimation of oestrogen excretion in pregnancy. PMID- 4315679 TI - Stimulation of ADH release by the renin-angiotensin system. PMID- 4315680 TI - Failure of blood pressure restoration to repair glomerular filtration rate in hypophysectomized rats. PMID- 4315681 TI - Synaptic sites in sympathetic and vagal cardioaccelerator nerves of the dog. PMID- 4315682 TI - Excitatory and inhibitory actions of acetylcholine on hearts of oyster and mussel. PMID- 4315683 TI - Effect of the administration of the antischistosomal drug niridazole on muscle glycogen levels of monkeys. PMID- 4315684 TI - Cyclic AMP and drug action. PMID- 4315685 TI - Endocrine hormones. PMID- 4315686 TI - Regulation of norepinephrine biosynthesis. PMID- 4315688 TI - Cellular aspects of invertebrate neuropharmacology. PMID- 4315687 TI - Psychopharmacology. PMID- 4315689 TI - Studies on cytochrome oxidase. I. Fine structure of cytochrome oxidase-rich submitochondrial membrane. PMID- 4315690 TI - Incorporation of carbohydrates into endogenous acceptors of liver microsomal fractions. PMID- 4315691 TI - The reduction of vitamin B 12a by carbon monoxide. PMID- 4315692 TI - The kinetics of 32P incorporation into the phospholipids of hepatic rough and smooth microsomal membranes of male and female rats. PMID- 4315693 TI - The 2,3-diphosphoglyceric acid phosphatase activity of phosphoglyceric acid mutase purified from human erythrocytes. PMID- 4315694 TI - Action of periodate on ovotransferrin and s metal complexes. PMID- 4315695 TI - Effects of dipyridamole on mitochondrial electron transport: a new inhibitor at site I. PMID- 4315696 TI - Inactivation of rabbit muscle L-alpha-glycerophosphate dehydrogenase by N alkylmaleimides. PMID- 4315697 TI - Lipid oxidation in biological membranes. I. Lipid oxidation in submitochondrial particles and microsomes induced by chaotropic agents. PMID- 4315699 TI - Aetiological factors in pleuralffusion. PMID- 4315698 TI - Lipid oxidation in biological membranes. II. Kinetics and mechanism of lipid oxidation in submitochondrial particles. PMID- 4315700 TI - [Bronchoscopic study of 649 patients with chronic pleurisy]. PMID- 4315701 TI - [Cholic acid transformation with the aid of a culture of Mycobacterium No. 1210]. PMID- 4315702 TI - [De novo synthesis of lecithinase by Clostridium perfringens]. PMID- 4315703 TI - [Zinc as a metal cofactor of lecithinase C of Clostridium perfringens]. PMID- 4315704 TI - [The role of cholinergic processes in the synaptic transmission in the brain cortex]. PMID- 4315705 TI - Effects of Clonidine on central sympathetic tone. PMID- 4315706 TI - Central and peripheral effects of 2-(2,6-dimethylphenylamino)-4-H-5,6-dihydro-1,3 thiazin (Bayer 1470) on the sympathetic system. PMID- 4315707 TI - Enterovirus isolation study in connection with polio immunization programme in Pondicherry. PMID- 4315708 TI - Actual aspects of the radioimmunological determination of plasma ACTH. PMID- 4315709 TI - Viral prostatitis. PMID- 4315711 TI - [Renin-angiotensin system in hypervolemia simulated by immersion]. PMID- 4315712 TI - [The pharmacotherapy of rheumatoid diseases (4): pathogenesis of inflammation of the joints]. PMID- 4315713 TI - [Infectious mononucleosis and its complications]. PMID- 4315714 TI - [Caudagraphy using methylglucamine iothalamate (Conray 60, Contrix 28)]. PMID- 4315716 TI - The ischemia test for glomus tumor: a new diagnostic test. PMID- 4315710 TI - [Renin-angiotensin-aldosterone system from the pathophysiological viewpoint]. PMID- 4315715 TI - Renal function and the renin-angiotensin system in the isolated perfused dog kidney. PMID- 4315717 TI - [Waldenstrom's disease and pulmonary images. 2 cases]. PMID- 4315718 TI - [On the fate of patients with primary broncho-pulmonary cancer. 215 cases]. PMID- 4315719 TI - [Carcinoid tumor with double, apparently primary, bronchial and ileal localization]. PMID- 4315720 TI - [2 cases of glucose 6-phosphate dehydrogenase deficiency revealed during treatment with para-amino-salicylic acid]. PMID- 4315721 TI - [Pulmonary mycobacteriosis caused by Mycobacterium avium. A recent case]. PMID- 4315722 TI - [Necrosing enteritis with hemorrhage during collective food poisoning]. PMID- 4315723 TI - Inhibition of a purified adrenal steroid 21-hydroxylating system by cytochrome P 450 particles. PMID- 4315725 TI - Adrenocortical function in Nigerians. (Evaluation of normal function and reaction to certain stress conditions). PMID- 4315724 TI - The fluorescence of delta 4-3-keto-11-deoxysteroids. I. Optimal conditions for the measurement of 11-deoxycortisol. PMID- 4315726 TI - [Problem of the "nothing-dehydrogenase" effect in the histochemical demonstration of dehydrating enzyme systems]. PMID- 4315727 TI - [Microspectrophotometry studies on Feulgen-stained primary goiter cells in infections with adenovirus type 3]. PMID- 4315728 TI - [Histochemical demonstration of soluble NAD-dependent dehydrogenases by means of PVA gel incubation]. PMID- 4315729 TI - Some histological, histochemical, and ultrastructural studies and hormone assays in a transplantable islet carcinoma of the Syrian hamster. PMID- 4315730 TI - Clear-cell sarcoma of tendons. A study of 4 cases. PMID- 4315731 TI - Changes in sensitivity to angiotensin and renin. Studies on normal, nephrectomized, ureterligated, hypoxic, partially corticectomized or medullectomized and renal or spontaneously hypertensive rats. PMID- 4315732 TI - Cell-mediated and humoral immune reactions against tumour-specific and viral antigens in relation to Rous sarcoma virus tumorigenesis in rats. PMID- 4315733 TI - Extrinsic nervous control of colonic motility and blood flow. An experimental study in the cat. PMID- 4315734 TI - Carotenoid pigments of Stigmatella aurantiaca (Myxobacterales).I. The minor carotenoids. PMID- 4315735 TI - In situ tumors in fetuses, newborns and young infants. PMID- 4315736 TI - Radiographically determined sternal ossification. An approach to skeletal maturity. PMID- 4315737 TI - Mechanism of oxidation of cytoplasmic reduced nicotinamide adenine dinucleotides in the developing rat liver. PMID- 4315738 TI - [Ovarian folliculo-thecoma]. PMID- 4315739 TI - [Gangrene due to perfringens]. PMID- 4315740 TI - [Changes in the activity of liver NADase in rats after administration of nicotinic acid, 3-methylpyridine and nicotinamide in excess]. PMID- 4315742 TI - [E.S.R. of the triplet excited state of bases and metallic complexes of porphyrins, the effect of temperature on the parameters of E.S.R. spectra]. PMID- 4315741 TI - [Content of some oxidative enzymes in the nuclear membrane in the rat liver]. PMID- 4315743 TI - [The content of arylsulfatase, adenosine triphosphatase, cathepsins and glucose-6 phosphatase in nuclear membranes in the rat's liver]. PMID- 4315744 TI - [The effect of hypertensin on the electrical and mechanical activity of the smooth muscle cells in blood vessels]. PMID- 4315746 TI - [Microspectrofluorometric study of accumulation and oxidation of benz(a)pyrene by yeast organisms]. PMID- 4315745 TI - [Discovery and study of a new kind of ESR signals characteristic of some neoplastic tissues]. PMID- 4315747 TI - [Study of melanins of Nadsoniella nigra by electron spin resonance (ESR)]. PMID- 4315748 TI - [Post-traumatic tarsal tunnel syndrome. Report of 35 personal observations]. PMID- 4315749 TI - Metabolism of sphingosine bases. 13. Enzymatic synthesis of 1-phosphate esters of 4t-sphingenine (sphingosine), sphinganine (dihydrosphingosine), 4 hydroxysphinganine (phytosphingosine) and 3-dehydrosphinganine by erythrocytes. PMID- 4315750 TI - [Basocellular epithelioma on histiocytofibroma]. PMID- 4315751 TI - [Changes in the urinary excretion by the maternal adrenals, during the 3d trimester of pregnancy, of placental steroids induced by stimulation]. PMID- 4315752 TI - [Peritoneal cytology and ovarian function]. PMID- 4315753 TI - The synthesis of an enzyme. PMID- 4315755 TI - [Precancerous enzyme defects in rat liver induced by dibutylnitrosamine and 1,2 dimethylhydrazine]. PMID- 4315756 TI - Selective ovarian angiography in trophoblastic disease. PMID- 4315754 TI - [Immunobiological aspects of blood. Humoral factors of natural resistance]. PMID- 4315757 TI - C cells of the normal human thyroid. PMID- 4315758 TI - [Poliomyelitis: immunologic bases and prophylactic deductions]. PMID- 4315759 TI - [Syndrome of the hilus of the upper limb]. PMID- 4315760 TI - [Long case history of a cylindroma]. PMID- 4315761 TI - [Functional state of the adrenal cortex in diverse heart defects]. PMID- 4315762 TI - [Glomus tumor in a rare location]. PMID- 4315763 TI - [Virus infections of the otorhinolaryngologic organs]. PMID- 4315764 TI - [Microbe-virus associations in various clinical forms of chronic tonsillitis in children]. PMID- 4315766 TI - [Mixed tumors in otorhinolaryngolic practice]. PMID- 4315765 TI - [Some laryngoscopic data in disease of the recurrent nerve]. PMID- 4315767 TI - Mechanisms in the control of insulin release by glucose and other substances. PMID- 4315768 TI - Hematologic changes associated with viral infection and hypobaric hypoxia. PMID- 4315769 TI - The effect of diethylaminoethyl dextran and agar overlay pH on plaque formation by two plaque-size variants of foot-and-mouth disease virus. AB - The effect of diethylaminoethyl (DEAE) dextran and agar overlay medium pH on a small-plaque (SP) and large-plaque (LP) foot-and-mouth disease virus (FMDV), type A, strain 119 (A119) was studied. The SP virus was inhibited under normal agar overlay but the addition of 100, 1,000 and 2,000 microg DEAE dextran/ml of agar overlay permitted plaque development. By using untreated and DEAE dextran-treated agar overlay medium, plaque formation by the SP virus was enhanced when the pH of agar medium was raised to a more alkaline level before overlay. Plaques formed by the LP virus were relatively uninhibited under the regular overlay but were larger in the presence of 1,000 microg DEAE dextran/ml. The enhancement of LP virus plaques occurred at various pH levels and was also inversely related to the hydrogen ion concentration of agar overlays; regular and DEAE dextrantreated alkaline overlays produced larger plaques. PMID- 4315770 TI - A spin label study of the effects of cholesterol in liposomes. PMID- 4315771 TI - Prosthetic treatment after radiation for oral cancer. PMID- 4315772 TI - Electrochemical and electron paramagnetic resonance studies of metalloporphyrins and their electrochemical oxidation products. PMID- 4315773 TI - Triplet-state electron spin resonance of the aromatic amino acids and proteins. PMID- 4315774 TI - Double resonance studies of anions formed in irradiated succinic and thiodiglycolic acid. PMID- 4315776 TI - Isolation, identification, and experimental transmission of herpesvirus T from an owl monkey (Aotus trivirgatus). PMID- 4315775 TI - Hormone syndromes associated with bronchogenic carcinoma. Clues to histologic type. PMID- 4315777 TI - Beta-glucuronidase, sulfatase, and phosphatase activities in the urine of dogs, monkeys, and mice. PMID- 4315778 TI - The effects of cesarean derivation and foster nursing procedures on enzootic viruses of the LSH strain of inbred hamsters. PMID- 4315780 TI - The incidence of poliovirus in chimpanzees (Pan troglodytes). PMID- 4315779 TI - Normal values for blood constituents of the baboon (Papio species). PMID- 4315782 TI - Cancer: DNA from RNA template. PMID- 4315781 TI - Serum and cerebral spinal fluid chemistry values for the monkey (Macaca mulatta). PMID- 4315783 TI - Uses for fructose. PMID- 4315784 TI - [Study of lactotransferrin in extracts of human cancerous kidney. Comparison with normal adult and fetal kidneys]. PMID- 4315785 TI - Distribution of tritiated daunomycin in man by a simplified method. PMID- 4315786 TI - Long-lived organic radicals formed by irradiation of FD&C blue no. 2 and thionine in aqueous solution. BNWL-715. 2. PMID- 4315787 TI - [On primary tumors of the parotid gland]. PMID- 4315788 TI - [Sensitivity to antibiotics in different serologic groups and types of Salmonella]. PMID- 4315789 TI - [Acinic cell tumors of the mucous glands. Mucous acinic cell carcinomas of the nose]. PMID- 4315791 TI - [Metabolic studies on rat kidney after administration of polythiazide, furosemide and ethacrynic acid. II. Changes in some enzymatic activities in mitochondria of the renal cortex and medulla]. PMID- 4315790 TI - [The cytochrome oxidase system of light-anaerobically and dark-aerobically grown cells of Rhodopseudomonas capsulata]. PMID- 4315792 TI - [Enzyme test, enzymatic course control and function test of the pituitary-adrenal system in long-term treatment of dermatomyositis using glucocorticoids]. PMID- 4315793 TI - [Management of bronchial asthma using a synthetic beta 1-18-corticotropin derivative]. PMID- 4315794 TI - [Radioimmunologic determination of angiotensin I and angiotensin II in human plasma]. PMID- 4315795 TI - [Significance of the renin-angiotensin system in the hypertension of aortic coarctation]. PMID- 4315796 TI - Antineoplastic action of methylglyoxal. PMID- 4315799 TI - [Acoustic neurinoma. 5 cases]. PMID- 4315798 TI - [Influence of bilateral nephrectomy on the renin-angiotensin system in man]. PMID- 4315797 TI - Comparison of production of avian sarcoma virus B77 by two tumour lines derived from the rat tumour RBI. PMID- 4315800 TI - [Bilateral primary bronchogenic cancers]. PMID- 4315801 TI - [The blocking action of human adenovirus type 16 on the formation of tumors caused by papovavirus SV40]. PMID- 4315802 TI - [Tumor induction by Rous sarcoma virus in adult rats. 2. Virologic and antigenic characteristics of primary and transplantable tumors in adult rats]. PMID- 4315803 TI - [The stimulating effect of inactivated influenza virus on the multiplication of herpes virus]. PMID- 4315804 TI - [Isolation of viruses from the bile of patients with infectious hepatitis]. PMID- 4315805 TI - Immunochemical characteristics of hamster antibodies reacting in complement fixation with polyoma virus-induced tumour antigen. PMID- 4315806 TI - [Dynamics of the total electrical activity of the brain in sleeping humans]. PMID- 4315807 TI - [The origin of wave-spike discharge: centrencephalic or centrasthenic?]. PMID- 4315808 TI - [Presynaptic inhibition in the olfactory bulb of frogs]. PMID- 4315809 TI - [Surgical management of breast carcinoma]. PMID- 4315810 TI - An aminopeptidase from human serum specific for hydrolysis of alpha-L dicarboxylic amino acid residues. II. Some properties and its relationship to the serum angiotensinase activity. PMID- 4315811 TI - Cytomorphometric and biochemical differences between the muscle cells in atria and ventricles of the guinea pig heart. PMID- 4315812 TI - Lithium carbonate and sleep in affective illness. PMID- 4315813 TI - Rapid diagnosis of respiratory disease due to adenovirus and mycoplasma. PMID- 4315814 TI - Neurovirulence of polioviruses isolated from sewage and stool of healthy children. I. Studies on neurovirulence, antigenic marker and RCT-40 mrker of type 2 strains. PMID- 4315815 TI - Selection and genetic studies on mutants of herpes simplex virus sensitive to sulfated agar polysaccharides. PMID- 4315816 TI - Selection of herpesvirus mutants producing mottled plaques in human fibroblast monolayers. (Brief report). PMID- 4315817 TI - Absence of heterologous antibody responses in human volunteers after rhinovirus vaccination. (Brief report). PMID- 4315818 TI - Oral administration of rhinoviruses grown at different temperatures in human diploid cells. (Briefeport). PMID- 4315819 TI - Effect of lyophilization on picornaviruses. (Brief report). PMID- 4315820 TI - Further analysis of physiochemical and immunologic properties of herpes simplex vus precipitating antigens. PMID- 4315821 TI - [Ribonucleic acid of parainfluenza vius type 3]. PMID- 4315822 TI - Characteristics of a paravaccinia virus from cattle. PMID- 4315823 TI - Increased resistance of SV40 transformed human amnion cells to poliovirus infection. PMID- 4315824 TI - Replication of poliovirus in human lymphocytes stimulated with specific antigens. PMID- 4315825 TI - Interferons of foot-and-mouth disease virus: a new assay for interferon. PMID- 4315826 TI - Synthesis of cellular and viral macromolecules under conditions of suboptimal temperature. PMID- 4315827 TI - ["Indifferent" epithelium in hormonopoiesis of the adenohypophysis]. PMID- 4315828 TI - [The behavior of the colloido-osmotic pressure of the blood of rats treated with angiotensin]. PMID- 4315829 TI - [Electrocardiographic changes in the rat caused by the administration of adenosine compounds. I. Changes produced by intravenous injection of ATP, 5'-AMP, 3',5' AMP cyclic and N6-2-O-dibutyryl-AMP cyclic]. PMID- 4315830 TI - [Electrocardiographic changes in the rat caused by administration of adenosine compounds. II. Independence of the innervation and the electrocardiographic effect of ATP and of N6-2-dibutyryl-AMP cyclic]. PMID- 4315832 TI - [Loss of the capacity of ACTH to induce sexual excitation caused by lesions of the areas of the brain accumulating testosterone]. PMID- 4315831 TI - [Electrocardiographic changes in the rat caused by the administration of adenosine compounds. 3. Influence of aminophylline on the electrocardiographic response to ATP, 5'AMP, 3'-5'-AMP cyclic and N6-2-O-dibutyryl-AMP cyclic]. PMID- 4315833 TI - [Phosphorylase phosphatase in the liver of hyperthyroid and hypothyroid rats]. PMID- 4315834 TI - [Blood sugar and liver glucose-6-phosphatase, phosphoglucomutase and phosphorylase in adult sheep after fasting for 10 days. Preliminary note]. PMID- 4315835 TI - [Important hematoma in a histiocytoma raising problems of melanoma diagnosis]. PMID- 4315836 TI - [Isolated glomus tumor of the left lower limb]. PMID- 4315837 TI - On the inhibitory influencesf the reaction products in the determination of lactate dehydrogenase activity, using lactate as a substrate. PMID- 4315839 TI - Lipolytic activities of stereoisomeric pentapeptides related to the partial structure of ACTH. PMID- 4315838 TI - [Informational etiology of mental diseases]. PMID- 4315840 TI - Kinetics of bovine liver aldehyde dehydrogenase. Effect of coenzyme and aldehyde structure. PMID- 4315841 TI - Complexes of liver alcohol dehydrogenase. Further studies on the rate of inactivation. PMID- 4315842 TI - Structural investigations on the 2-keto-3-deoxyoctonate region of lipopolysaccharides. PMID- 4315843 TI - The chemical and electronic structure of the neutral flavin radical as revealed by electron spin resonance spectroscopy of chemically and isotopically substituted derivatives. PMID- 4315844 TI - The effect of triton X-100 on the respiratory chain enzymes of a heart-muscle preparation. PMID- 4315845 TI - Inheritance of responsiveness to pertussis HSF in mice. PMID- 4315846 TI - Replication of foot-and-mouth disease virus ribonucleic acid. PMID- 4315847 TI - Investigations on virus production in RSV mammalian tumours. PMID- 4315848 TI - Inhibition of infectious bovine rhinotracheitis virus multiplication by thiosemicarbazones. PMID- 4315849 TI - Enhanced or inhibited plaque formation of superinfecting viruses in Yaba virus infected cells. PMID- 4315850 TI - [Clinical conferences. Adrenal gland tumours]. PMID- 4315851 TI - Electron microscopic study of neuroblastoma. PMID- 4315852 TI - A report of an actinomycin D study group in Japan. PMID- 4315853 TI - [Causes of fatty liver development following partial hepatectomy and relation of this change to liver regeneration]. PMID- 4315854 TI - DNA polymerase activities associated with smooth membranes and ribosomes from rat liver and hepatoma cytoplasm. AB - Deoxyribonucleic acid polymerase activity that prefers denatured DNA primer concentrates with the smooth membranes during sucrose gradient centrifugation of rat liver and hepatoma cytoplasmic extracts. The activity in this fraction is eightfold higher in hepatoma tissue. Deoxyribonucleic acid polymerase activity that prefers native DNA primer concentrates with the free ribosome fraction from both tissues. PMID- 4315855 TI - [Analysis of tumor transformation of tissue. I. Indications of the degree of autonomy and their appearance]. PMID- 4315856 TI - [Ultrastructure of the Rous sarcoma]. PMID- 4315857 TI - Interferon stimulation and other phenotypic properties of two variants of polyoma virus. PMID- 4315858 TI - [Concentration of foot-and-mouth disease virus by polyethylene glycol]. PMID- 4315859 TI - Arbovirus identification by an agar-gel diffusion technique. AB - A double diffusion-in-agar test was used to investigate precipitation reactions of 75 arboviruses. Specific reactions were regularly observed with members of arbovirus groups B, California, Simbu, Turlock, Hart Park, vesicular stomatitis, and several other arboviruses as well as with a member of the Tacaribe group and a herpesvirus. The results demonstrated the feasibility of applying this technique to the identification of arboviruses. PMID- 4315860 TI - Formation of hydrogen peroxide by group N streptococci and its effect on their growth and metabolism. AB - The formation of hydrogen peroxide by group N streptococci was found to occur through the action of a reduced nicotinamide adenine dinucleotide (NADH) oxidase which catalyzed the oxidation of NADH by molecular oxygen. The enzyme was activated by flavine adenine dinucleotide. Whereas some of the hydrogen peroxide formed was removed through the action of an NADH peroxidase, sufficient accumulated in media to inhibit the growth, respiration, and viability of these organisms. The amount of hydrogen peroxide which accumulated varied among strains, and this variation could be related to differences in the properties of the NADH oxidase present. PMID- 4315861 TI - Enzymatic removal of diacetyl from beer. II. Further studies on the use of diacetyl reductase. AB - Diacetyl removal from beer was studied with whole cells and crude enzyme extracts of yeasts and bacteria. Cells of Streptococcus diacetilactis 18-16 destroyed diacetyl in solutions at a rate almost equal to that achieved by the addition of whole yeast cells. Yeast cells impregnated in a diatomaceous earth filter bed removed all diacetyl from solutions percolated through the bed. Undialyzed crude enzyme extracts from yeast cells removed diacetyl very slowly from beer at its normal pH (4.1); at a pH of 5.0 or higher, rapid diacetyl removal was achieved. Dialyzed crude enzyme extracts from yeast cells were found to destroy diacetyl in a manner quite similar to that of diacetyl reductase from Aerobacter aerogenes, and both the bacterial and the yeast extracts were stimulated significantly by the addition of reduced nicotinamide adenine dinucleotide (NADH). Diacetyl reductase activity of four strains of A. aerogenes was compared; three of the strains produced enzyme with approximately twice the specific activity of the other strain (8724). Gel electrophoresis results indicated that at least three different NADH-oxidizing enzymes were present in crude extracts of diacetyl reductase. Sephadex-gel chromotography separated NADH oxidase from diacetyl reductase. It was also noted that ethyl alcohol concentrations approximately equivalent to those found in beer were quite inhibitory to diacetyl reductase. PMID- 4315862 TI - Virus particle content of smallpox vaccines. AB - Calf lymph smallpox vaccines contain too much extraneous debris for an accurate assessment of their virus particle content. The process of partial purification of the vaccine utilizing enzymatic digestion by chymotrypsin, subtilisin, and collagenase solubilized enough debris to permit electron microscopic virus particle count. Enzyme treatment did not degrade or destroy the virus nor did it reduce the infective titer. Commercial vaccines studied ranged in virus content from 1.89 x 10(9) to 1.09 x 10(11) virus particles/ml. The pocking efficiencies on the chorioallantoic membrane of some of these vaccines varied from 200 to 1,200 virus particles per pock-forming unit. PMID- 4315863 TI - [On the question of "grading" of gliomas in animals]. PMID- 4315864 TI - [Tetanus at Abidjan]. PMID- 4315866 TI - Physical and chemical studies of Mengo virus variants. 3. Absorbance--temperature profiles, sedimentation in dextran sulfate gradients, and total-infectious particle ratios. PMID- 4315865 TI - Virus isolations from sewage and from a stream receiving effluents of sewage treatment plants. AB - In order to detect viruses in sewage or streams, it is first necessary to concentrate the virus present in the fluid sample. Available methods are not readily manageable for concentrating virus from large volumes of fluid, and have not always yielded high recovery rates. In the study described in this paper, a method for concentration of viruses by adsorption on insoluble cross-linked maleic anhydride polyelectrolytes has been utilized to survey the viral flora of sewage and of a stream receiving sewage effluents, in a residential area of Houston, Texas. On a single day the virus flow at different points along the stream varied from 304 000 to 6 014 000 PFU/min. From 84 samples each of 1 US gal, 14 520 isolates were obtained, chiefly echovirus type 7 and polioviruses of all 3 types, some of them with characteristics of virulent wild strains. With virus isolation rates as high as those achieved, it is now possible to monitor virus in natural waters more effectively. PMID- 4315867 TI - Effects of chloramphenicol and its isomers and analogues on the mitochondrial respiratory chain. PMID- 4315868 TI - A review of literature on infectious mononucleosis with special emphasis on the possible relationship between infectious mononucleosis and infectious hepatitis. PMID- 4315869 TI - Cystic and solid ovarian tumors in children: a 44-year review. PMID- 4315870 TI - Problems of radiation dosimetry in endolymphatic therapy with radioactive isotopes. PMID- 4315871 TI - Endolymphatic radiotherapy in malignant lymphomas--long term results. PMID- 4315873 TI - Correlation conferences in radiology and pathology. Glomus jugulare tumor. PMID- 4315872 TI - [Possibilities and limits of mediastinoscopy for the evaluation of metastatic and primary diseases of the mediastinum and the lung]. PMID- 4315874 TI - Comparative susceptibility of non-inbred and strain LSH inbred Syrian hamsters to the oncogenic adenoviruses. PMID- 4315875 TI - Inhibition of the acute ethanol-induced fatty liver by pyrazole. PMID- 4315876 TI - Pituitary cytology of rats with Leydig-cell tumors induced by low-level testicular irradiation. PMID- 4315877 TI - Adrenal gland factors in magnesium-deficient rats. PMID- 4315878 TI - [Observations on patients convalescing from hepatitis in a polyclinic]. PMID- 4315880 TI - [Prevalence of generally not accepted therapeutic procedures in free practice. Result of a second poll]. PMID- 4315881 TI - [Immunization against gas gangrene and tetanus with sexta-anatoxin (in experiments with animals)]. PMID- 4315882 TI - A clinical experimental investigation of the rate of cell proliferation in human malignant tumours. PMID- 4315883 TI - Virus as the cause of rhinopharyngeal carcinoma. PMID- 4315884 TI - Titration of hormone metabolites in cases of nasopharyngeal angiofibroma five years after the operation. PMID- 4315885 TI - Development of strains of genus Candida and genus Torulopsis resistant to antimycotics. PMID- 4315886 TI - [Research on enzymes of polyphosphate metabolism in yeasts: I. Study of the variation of enzyme activities as a function of intracellular concentration in polyphosphates]. PMID- 4315887 TI - [Clinical trial of a new coenzyme complex in patients with liver disease]. PMID- 4315888 TI - [Antipyretics, analgesics and plasmakinins]. PMID- 4315889 TI - [Mode of action of various antibiotics]. PMID- 4315890 TI - Chemical and biochemical changes in subcellular fractions of guinea pig liver during infection with Coxiella burneti. AB - Livers of uninfected guinea pigs and of guinea pigs infected with Coxiella burneti were fractionated into smooth endoplasmic reticulum, rough endoplasmic reticulum (RER), pellet, and cell sap fractions. The ribonucleic acid (RNA) and protein of each fraction were determined, and the phosphorylase, glucose-6 phosphatase, and glucosyl transferase (glycogen synthetase) activities of each fraction were measured. Decreased RNA, protein, and enzyme activities were found in the RER and pellet fractions of infected livers, with the greatest differences in the RER. The evidence indicates a solubilization of the phosphorylase and synthetase, with the enzymes moving from the RER and glycogen-containing pellet fraction to the cell sap. The data suggest the RER as a target during Q fever. PMID- 4315891 TI - Endo-N-acetyl-glucosaminidase from Clostridium perfringens, lytic for cell wall murein of gram-negative bacteria. AB - An endo-N-acetyl-glucosaminidase which degrades the murein (peptidoglycan) sacculi of the cell walls of Escherichia coli and Spirillum serpens, but not those of Micrococcus lysodeikticus and Sarcina lutea, is present as a contaminant in a "phospholipase C" from Clostridium perfringens. The specificity of enzyme action was elucidated by reduction of liberated glycosidic groups with NaBH(4) and identification of glucosaminol as the reduction product. This finding contradicts previous reports associating cell wall breakdown with specific phospholipase action. PMID- 4315892 TI - Comparative metabolism of vegetative and sporulating cultures of Clostridium thermosaccharolyticum. AB - Cultures of Clostridium thermosaccharolyticum, under conditions of restricted growth achieved by slow feeding of glucose, showed a high degree of sporulation. Analysis of the end products showed an accumulation of ethyl alcohol in addition to butyrate and acetate, whereas, in the nonsporulating cultures, acetate and butyrate were the principal products. Incorporation of uniformly labeled (14)C glucose by sporulating cells was three to four times higher than by nonsporulating cells. The efficiency of acetate assimilation into the lipid fraction of sporulating cells was at least two times higher than that of glucose. When starch was used as the carbon source, the growth rate was reduced; sporulation occurred, and the end products and carbon distribution were similar. Alcohol dehydrogenase, glucose-6-phosphate dehydrogenase, and 6-phosphogluconate dehydrogenase were preferentially formed by sporulating cells. In vegetative cells, the formation of these enzymes was repressed if the glucose concentration in the medium was increased. The change in enzyme activity appeared to be related to a morphological change in the cells and indicated an altered metabolic pattern for sporulating cells. PMID- 4315893 TI - Mapping of the nadB locus adjacent to a previously undescribed purine locus in Escherichia coli K-12. AB - It is proposed that all mutants blocked in the de novo pathway of nicotinamide adenine dinucleotide biosynthesis be designated nad rather than nic. It is further suggested that mutants blocked in the pyridine nucleotide cycle be designated pnc. The nadB locus and a previously unidentified pur locus are cotransducible. These two loci have been mapped near minute 49 on the standard genetic map of Escherichia coli. The order of genes in that region is purC-guaB purG-glyA-pur-nadB-tyrA-pheA. PMID- 4315894 TI - UGA nonsense mutations in Salmonella typhimurium. AB - Salmonella typhimurium strain LT-2 carries a weak UGA suppressor activity. This activity prevents the detection of some UGA mutants as auxotrophs and probably accounts for the rarity of his UGA mutants in this strain. A selection method is described which permits the isolation of these rare his UGA mutants. Map distribution of his UGA mutations is normal, and their polarity effects are indistinguishable from the polarity effects of amber and ochre mutations at similar locations. Isolation and properties of a prototrophic his UGA mutant are described. UGA mutants are common among lac mutants isolated from Salmonella strains carrying an F'lac episome. Apparently the suppressor activity is insufficient to prevent detection of lac UGA mutants. It is not yet clear whether the suppressor activity plays an important role in normal cell physiology. PMID- 4315895 TI - Studies on the ultrastructure of Bordetella pertussis. I. Morphology, origin, and biological activity of structures present in the extracellular fluid of liquid cultures of Bordetella pertussis. AB - Two distinct particles have been recognized in the extracellular fluid of B. pertussis cultures. Both appeared to arise from the surface (cell wall) of the organism. One of these, a membranous particle, seemed to derive from long projections on the organism composed of the outer membrane of the cell wall. The second particle, a fine filament, was not readily comparable with any previously described bacterial structure. The two particles could be separated from each other by gradient centrifugation in CsCl. Lymphocytosis-promoting factor and histamine-sensitizing activity were only associated with fractions containing the fine filaments. PMID- 4315896 TI - Interferon in rabbit brain, cerebrospinal fluid and serum following administration of polyinosinic-polycytidylic acid. PMID- 4315897 TI - Enhancement of virus multiplication and interferon production by cortisone in ocular herpesvirus infection. PMID- 4315898 TI - Case reports of three teleost neoplasms. PMID- 4315899 TI - Cytological and comparative biochemical studies on normal and neoplastic earthworm tissues. PMID- 4315900 TI - Neoplasia and primitive vertebrate phylogeny: echinoderms, prevertebrates, and fishes--A review. PMID- 4315901 TI - Neoplasia and transplantation immunity in annelids. PMID- 4315902 TI - Effect of diphenylhydantoin on the metabolism of dexamethasone. PMID- 4315903 TI - Histochemical observations on the tegumentary epithelium and interproglottidal glands of Moniezia expansa (Rud., 1805) (Cestoda, Cyclophyllidea). PMID- 4315904 TI - Attitudes of stroke patients toward rehabilitation and recovery. PMID- 4315905 TI - Primary adenocarcinoma of the lung in men. PMID- 4315906 TI - [Conjugated estrogens, estrogen excretion and antigonadotropic effect]. PMID- 4315907 TI - Histochemistry of a cotylocercous cercaria. II. Hydrolytic and oxidative enzymes in Plagioporus lepomis. PMID- 4315908 TI - Biochemistry of the dog hookworm. 3. Oxidative phosphorylation. PMID- 4315909 TI - [Histochemical enzyme pattern of the mammary gland during the experimental influence of sex hormones]. PMID- 4315912 TI - Studies on angiotensin like activity in rat uterus. I. PMID- 4315910 TI - [Histochemical behavior of azolesterases and other oxidoreductases during atresia of follicles in the ovaries of some rodents]. PMID- 4315911 TI - The dual localization of beta-glucuronidase in rat thyroid. PMID- 4315913 TI - Metabolism of sodium iodide, calcium iodate, and pentacalcium orthoperiodate initially placed in the bovine rumen or abomasum. PMID- 4315914 TI - Estimation of rumen microbial nitrogen by three analytical methods. PMID- 4315915 TI - Effect of perchlorate on the milk-plasma radioiodine ratio of intact and thyroidectomized goats. PMID- 4315916 TI - The development of an improved ZrSiO4 prophylactic paste. PMID- 4315917 TI - [Clinical aspects, diagnosis, and treatment of retroperitoneal teratoid tumors in children]. PMID- 4315918 TI - [Immunosuppressive agents in hematology]. PMID- 4315919 TI - Wilms' tumor. PMID- 4315920 TI - Differential susceptibility to a viral agent in mice housed alone or in groups. PMID- 4315921 TI - [Analysis by zonal centrifugation in a saccharose gradient of viral particles contained in a preparation of the foot-and-mouth disease virus]. PMID- 4315923 TI - [Removal of angiofibroma of the external nose with simultaneous plastic repair with lyophilized homologous cartilage]. PMID- 4315922 TI - [Roentgenodiagnosis of chronic sphenoiditis with the use of contrast examination]. PMID- 4315924 TI - [Studies on the relation of chronologic and biologic age to spiroergometric measurements, cardiac volume, anthropometric data and skeletal muscle strength in 8 to 18-year-old boys]. PMID- 4315925 TI - [Rare forms of acute leukemia with vertebral and nervous system lesions]. PMID- 4315926 TI - Neurotransmitter releasing effects of two quaternary nicotine analogues. PMID- 4315927 TI - Viral hepatitis in Israel: morbidity and mortality data. PMID- 4315928 TI - An automated method for the determination of lactic acid. PMID- 4315929 TI - The effect of angiotensin on the excretion of free and conjugated 5 hydroxyindoleacetic acid in man. PMID- 4315930 TI - [Changes in the kidney in infants with cytomegaly]. PMID- 4315931 TI - Phospholipid synthesis and exchange in isolated liver cells. AB - 1. The [(32)P]phosphate incorporated into the phospholipids of isolated rat hepatic cells is present in phosphatidic acid and to a smaller extent in phosphatidylinositol. 2. The ability to synthesize nitrogen-containing phospholipids is restored by adding a liver supernatant fraction, and it is suggested that the metabolic deficiency is caused by the leakage of cytoplasmic enzymes of the synthetase system from the cells. 3. Fortified cell preparations were pulse-labelled with [(32)P]phosphate, [Me-(14)C]choline, [2 (14)C]ethanolamine and [U-(14)C]inositol and the subsequent fate of the labelled microsomal and mitochondrial phospholipids followed. 4. A fall in the specific radioactivity of microsomal phospholipids and a rise in that of mitochondrial phospholipids is interpreted as providing evidence of a transfer of labelled phospholipid molecules from the synthetic site (endoplasmic reticulum) to the mitochondrial membranes in the intact cells. 5. The formation of the phospholipids of mitochondrial membranes is discussed. PMID- 4315932 TI - Equilibrium relations between the cytoplasmic adenine nucleotide system and nicotinamide-adenine nucleotide system in rat liver. AB - 1. The ratio [ATP]/[ADP][P(i)], as measured by direct determination of the three components in rat liver, was found in various nutritional states to have approximately the same value as the ratio [ATP]/[ADP][P(i)] calculated from the concentrations of lactate, pyruvate, glyceraldehyde phosphate and 3 phosphoglycerate on the assumption that lactate dehydrogenase, glyceraldehyde phosphate dehydrogenase and 3-phosphoglycerate kinase are at near-equilibrium in the liver. This implies that the redox state of the NAD couple in the cytoplasm is linked to, and partially controlled by, the phosphorylation state of the adenine nucleotides. 2. The combined equilibrium constant of the glyceraldehyde 3 phosphate dehydrogenase and 3-phosphoglycerate kinase reactions at 38 degrees C and I0.25, was found to be 5.9x10(-6). 3. The fall of the [NAD(+)]/[NADH] ratio in starvation and other situations is taken to be the consequence of a primary fall of the [ATP]/[ADP][HPO(4) (2-)] ratio. PMID- 4315933 TI - Pathways leading to and from serine during growth of Pseudomonas AM1 on C1 compounds or succinate. AB - 1. The following enzymes of the phosphorylated pathway of serine biosynthesis have been found in methanol- and succinate-grown Pseudomonas AM1: phosphoglycerate dehydrogenase, phosphoserine-alpha-oxoglutarate aminotransferase and phosphoserine phosphohydrolase. Their specific activities were similar in the organism grown on either substrate. 2. A procedure for preparation of auxotrophic mutants of Pseudomonas AM1 is described involving N-methyl-N'-nitro-N nitrosoguanidine as mutagen and a penicillin enrichment step. 3. A mutant, M-15A, has been isolated that is unable to grow on methanol and that lacks phenazine methosulphate-linked methanol dehydrogenase. The mutant is able to grow on methylamine, showing that the amine is not oxidized by way of methanol. 4. Loss of methanol dehydrogenase activity in mutant M-15A led to loss of phenazine methosulphate-linked formaldehyde dehydrogenase activity showing that the same enzyme is probably responsible for both activities. 5. A mutant, 20B-L, has been isolated that cannot grow on any C(1) compound tested but can grow on succinate. 6. Mutant 20B-L lacks hydroxypyruvate reductase, and revertants that regained the ability to grow on methanol, methylamine and formate contained hydroxypyruvate reductase activity at specific activities similar to that of the wild-type organism. This shows that hydroxypyruvate reductase is necessary for growth on methanol, methylamine and formate but not for growth on succinate. 7. The results suggest that during growth of Pseudomonas AM1 on C(1) compounds, serine is converted into 3-phosphoglycerate by a non-phosphorylated pathway, whereas during growth on succinate, phosphoglycerate is converted into serine by a phosphorylated pathway. PMID- 4315934 TI - Activation of delta-aminolaevulate synthetase in extracts of Rhodopseudomonas spheroides. AB - 1. The spontaneous activation of delta-aminolaevulate synthetase in extracts from Rhodopseudomonas spheroides grown semi-anaerobically in the light requires oxygen and does not take place anaerobically in the dark. 2. Activation is completely prevented by azide or cyanide and is partially inhibited by chlorpromazine. These compounds inhibit markedly the succinoxidase activity of extracts. 3. NADH delays activation, but when it has been oxidized by the extract activation begins at the normal rate and complete activation occurs. By contrast both the rate and the extent of activation are markedly decreased by even small amounts of carboxylic acids. 4. The inhibitory effects of succinate and citrate on activation can be prevented by malonate and fluorocitrate respectively. 5. These results suggest that for activation to occur some endogenous compound has to be oxidized via the electron transport chain. 6. Activation occurs under anaerobic conditions in the light, probably by photo-oxidation. PMID- 4315935 TI - Factors affecting the permeability of isolated fat-cells from the rat to [42K] potassium and [36Cl] chloride ions. AB - 1. The effluxes of (42)K(+) and (36)Cl(-) from isolated fat-cells from the rat were studied under a variety of conditions known to affect the metabolism of the cells. 2. (42)K(+) efflux from isolated fat cells was increased in a Na(+)-free high-K(+) medium and decreased in a K(+)-free medium. The existence of K(+) exchange diffusion across the fat-cell membrane is suggested. 3. (36)Cl(-) efflux from isolated fat-cells was decreased when the Cl(-) component of the wash medium was replaced by acetate. The basal (36)Cl(-) efflux is suggested to be partly by Cl(-) exchange diffusion and partly in company with a univalent cation. 4. A variety of lipolytic stimuli, adrenaline, adrenocorticotrophic hormone, N-6,O-2' dibutyryladenosine cyclic 3':5'-monophosphate and theophylline, increased (42)K(+) efflux from isolated fat-cells. The adrenaline stimulation was biphasic; an initial, rapid and transient increase in (42)K(+) loss from the fat-cells was followed by a slower, more prolonged, increase in (42)K(+) efflux. The initial phase was inhibited by phentolamine but not by propranolol. 5. Insulin increased (42)K(+) efflux only after preincubation with the cells. PMID- 4315936 TI - [Effect of actinomycin D on the development of poliovirus]. PMID- 4315937 TI - [Specular behavior of guanidine-dependent viral mutants in relation to the original sensitive strains]. PMID- 4315938 TI - [Effect of histamine on neuromuscular transmission in the rat]. PMID- 4315939 TI - [Factors influencing the formation of endogenous hematopoietic colonies in the spleen of the mouse after panirradiation. II. Effects of stress due to cold and of hormones]. PMID- 4315940 TI - [Quantitative evaluation of the cytopathological effect of poliovirus by incorporation of neutral red]. PMID- 4315941 TI - [Estrogens and the renin-angiotensinogen reaction]. PMID- 4315942 TI - [Action of ACTH and hydrocortisone on the renin-angiotensinogen reaction]. PMID- 4315943 TI - [The renin-angiotensinogen reaction with different concentrations of urea]. PMID- 4315944 TI - Enteropathogenic factors of food-poisoning Clostridium perfringens type A. PMID- 4315945 TI - Response of ligated intestinal loops in lambs to an enteropathogenic factor of Clostridium perfringens type A. PMID- 4315946 TI - Tumors induced in hamsters by a respiratory-associated canine adenovirus (A26 61). PMID- 4315947 TI - Cyclic AMP and calcium uptake of the sarcoplasmic reticulum in relation to increased rate of relaxation under the influence of catecholamines. PMID- 4315948 TI - Reduction of renin-release by puromycin. PMID- 4315949 TI - [Oral vaccination against poliomyelitis using trivalent vaccines]. PMID- 4315951 TI - [Histochemistry of the chick neuropil during ontogenesis--true hyperstriatum]. PMID- 4315952 TI - [Enzyme-histochemical studies on the nervous system. 3. Distribution of some hydrolases in the nervous system of the earthworm (Eisenia foetida)]. PMID- 4315953 TI - Studies on the histochemical "leucine aminopeptidase" reaction. VI. The selective demonstration of cathepsin B activity by means of the naphythylamide reaction. PMID- 4315954 TI - Proteins of vesicular stomatitis virus: kinetics and cellular sites of synthesis. AB - FIVE VIRAL PEPTIDES SYNTHESIZED IN L CELLS INFECTED WITH VESICULAR STOMATITIS (VS) VIRUS WERE IDENTIFIED BY POLYACRYLAMIDE GEL ELECTROPHORESIS AND DESIGNATED AS FOLLOWS: nucleoprotein N, a membrane glycoprotein G, a membrane surface protein S, and two nonstructural proteins NS1 and NS2. A slowly migrating minor structural protein L also present in infected cells is probably an aggregate. Incorporation of (3)H-amino acids into each viral protein could be detected by the 2nd hr after infection and even earlier for protein N which is synthesized in the greatest amount. There was no evidence of regulation of viral protein synthesis at the transcriptive level; nonstructural and structural proteins were synthesized throughout the cycle of infection. Short pulses of (3)H-amino acids revealed no uncleaved precursor peptides that could be chased into structural peptides. Proteins N and S were chased into released virions but protein G was apparently incorporated into virions as it was being synthesized. VS viral proteins of infected cells were released by mechanically disrupting cytoplasmic membrane by nitrogen decompression and fractionated by high-speed centrifugation. Protein NS1 was present in the nonsedimentable cytoplasmic fraction throughout the cycle of infection. The nucleoprotein N was recovered primarily from the nonsedimentable fraction early in infection but aggregated into a sedimentable component, presumably the nucleocapsid, later in infection. Proteins G and S were always present in the sedimentable fraction of mechanically disrupted infected cells, presumably in association with plasma membrane. Exposure of infected cells to the membrane-dissolving agent, digitonin, resulted in solubilization of most of protein G and all of protein S but not of protein N. These experiments are compatible with the hypothesis that VS viral proteins G and S are synthesized at and inserted into plasma membrane which envelopes a nucleocapsid core to form the VS virion. PMID- 4315950 TI - [The impulse conducting system of birds. Histochemical and electron microscopy studies]. PMID- 4315955 TI - Genetic characteristics of conditional lethal mutants of vesicular stomatitis virus induced by 5-fluorouracil, 5-azacytidine, and ethyl methane sulfonate. AB - One hundred and seventy-five temperature-sensitive (ts) mutants of vesicular stomatitis virus (type Indiana-C) induced by 5-fluorouracil (FU), 5-azacytidine (ACR), and ethyl methane sulfonate (EMS) have been assigned to four complementation groups by a qualitative test. Group I contains 151 mutants; group II, 2 mutants; group III, 1 mutant; and group IV, 15 mutants; 6 are unclassified. FU was much more effective as a mutagen than either ACR or EMS. The proportion of the mutants belonging to groups I and IV, however, was similar in the case of all three mutagens. Fifteen mutants from groups I and IV have been used to obtain quantitative complementation data. Both groups appear to be homogeneous. Complementation yields increase with increasing multiplicity, but the number of particles per cell required to elicit maximal complementation is small. The pattern of genetic recombination parallels that of complementation. No recombination could be detected in crosses within group I (<0.001%) or group IV (<0.07%), whereas recombination (0.31 to 3.4%) was observed in crosses between groups I and IV. Recombination frequency did not increase with multiplicity above an input of 0.6 plaque-forming units per cell. Many group I mutants have very low reversion rates, and BHK 21 clone 13 cells infected with one of these mutants have been "cured" of infection by prolonged exposure at the restrictive temperature. PMID- 4315956 TI - Quantitative characteristics of the transformation of hamster cells by PARA (defective simian virus 40)-adenovirus 7. AB - An in vitro method for the quantitative measurement of transformation in hamster embryo fibroblasts by the PARA [defective simian virus 40 (SV40)]-adenovirus 7 hybrid has been developed. Transformation by PARA particles followed one-hit kinetics with a ratio of 1 focus-forming unit per 250 plaque-forming units. The method of viral adsorption had a direct effect upon the total number of foci which developed but not on the quantitative aspects of this assay. A fluorescent focus assay was developed which provided a direct correlation of the observed morphological transformation and the presence of the PARA genome. This fluorescent-focus assay utilized detection of the SV40 tumor antigen, which was present in all foci transformed by PARA. Single foci induced by PARA were isolated and grown into cell lines. Two types of foci were observed and isolated; the first contained cells having a cuboidal or SV40-type morphology, and the second consisted of epithelial or adenovirus-type transformed cells. Both types contained the SV40 tumor and SV40 surface antigens as determined by the indirect fluorescence technique; however, only the epithelial cells contained the adenovirus 7 tumor antigen. All five cell lines which were injected into weanling Syrian hamsters were found to be oncogenic. These cell lines induced antibodies to both SV40 and adenovirus 7 tumor antigens in tumor-bearing animals. PMID- 4315957 TI - Initial site of synthesis of virus during rescue of simian virus 40 from heterokaryons of simian virus 40-transformed and susceptible cells. AB - Simian virus 40 (SV40) can be rescued from certain SV40-transformed hamster cells by fusion with susceptible African green monkey kidney (CV-1) cells, in the presence of ultraviolet-irradiated Sendai virus. We have determined the sites in which SV40 is produced during rescue in these heterokaryons. To determine the sequence, nuclei were isolated from fused cells at various times after fusion, separated on sucrose-density gradients, and assayed for infectious center formation and virus content on CV-1 monolayers. Virus was first detected in the transformed nucleus (40 hr postfusion), and later associated with both transformed and susceptible nuclei (68 to 72 hr). Viral rescue apparently does not depend upon the transfer of SV40 deoxyribonucleic acid to a susceptible CV-1 nucleus, since the transformed nucleus is the primary site of virus production. The time course of certain cytological events in the rescue process and in productive infection was found to be similar. PMID- 4315959 TI - Phenotypic mixing of envelope proteins of the parainfluenza virus SV5 and vesicular stomatitis virus. AB - Cells mixedly infected with parainfluenza virus SV5 and vesicular stomatitis virus (VSV) yield phenotypically mixed virions, in addition to both parental types. Two types of phenotypically mixed virions have been identified: 0.6 to 1.2% of the VSV plaque formers were neutralized by SV5 antiserum, but not by VSV antiserum, suggesting the presence of a VSV genome in an SV5 envelope; 9 to 45% of the VSV plaque formers were neutralized by both antisera, indicating the presence of both SV5 and VSV antigens in their envelopes. The presence of SV5 antigen in virions with the typical bullet-shaped appearance of VSV was confirmed with ferritin-labeled anti-SV5 antibody. In contrast to standard VSV, phenotypically mixed virions adsorbed to and eluted from chicken erythrocytes, indicating that these virions contained in their envelopes SV5 hemagglutinin, and possibly neuraminidase. Thus, the VSV nucleocapsid can interact with membranes which contain SV5 proteins in the manner which leads to virus maturation, and the production of a high yield of phenotypically mixed virions with the morphology of VSV indicates that this process can function efficiently. No evidence of genetic recombination between the two viruses was found. These results raise the possibility of an evolutionary relatedness between the paramyxoviruses and the rhabdoviruses. PMID- 4315958 TI - Biochemical consequences of type 2 adenovirus and Simian virus 40 double infections of African green monkey kidney cells. AB - African green monkey kidney (AGMK) cells were nonpermissive hosts for type 2 adenovirus although the restriction was not complete; when only 3 plaque-forming units/cell was employed as the inoculum, the viral yield was about 0.1% of the maximum virus produced when simian virus 40 (SV40) enhanced adenovirus multiplication. The viral yield of cells infected only with type 2 adenovirus increased as the multiplicity of infection was increased. Type 2 adenovirus could infect almost all AGMK cells in culture; adenovirus-specific early proteins and DNA were synthesized in most cells, but small amounts of late proteins were made in relatively few cells. Even when cells were infected with both SV40 and adenovirus, only about 50% were permissive for synthesis of adenovirus capsid proteins. Approximately the same quantity of adenovirus deoxyribonucleic acid (DNA) was synthesized in the restricted as in the SV40-enhanced infection. However, in cells infected with SV40 and type 2 adenovirus, replication of SV40 DNA was blocked, multiplication of SV40 was accordingly inhibited, and synthesis of host DNA was not stimulated. To enhance propagation of type 2 adenovirus, synthesis of an early SV40 protein was essential; 50 mug of cycloheximide per ml prevented the SV40-induced enhancement of adenovirus multiplication, whereas 5 x 10(-6)m 5-fluoro-2-deoxyuridine did not abrogate the enhancing phenomenon. PMID- 4315960 TI - Morphological changes in productive and abortive infection by feline herpesvirus. AB - Feline herpesvirus produces characteristic morphological alterations in feline kidney cells. Nucleocapsid particles are formed in infected nuclei and are enveloped as they pass through the modified inner nuclear membrane. Aggregates of dense granular material and filamentous structures also regularly appear in infected nuclei. Infection of human embryonic lung cells by feline herpesvirus results in the appearance of intranuclear inclusion bodies, aggregates of dense granular material, and bundles of parallel filaments but no nucleocapsid particles. PMID- 4315962 TI - [American neurology for Swedish use]. PMID- 4315963 TI - [Insulin biosynthesis, storage and secretion. 10. Some properties of insulin granula]. PMID- 4315964 TI - Mammary intraductal carcinoma in a buffalo (Bubalus bubalis). PMID- 4315961 TI - Replication of Sendai virus. II. Steps in virus assembly. AB - Chick embryo fibroblast cultures infected with Sendai virus were incubated with (3)H-uridine in the presence of actinomycin D beginning at 18 hr after infection. The 35 and 18S virus-specific ribonucleic acid (RNA) components were found in a ribonuclease-sensitive form in the cell and appeared to be associated with polyribosomes. Newly synthesized 57S viral RNA was rapidly coated with protein to form intracellular viral nucleocapsid, and no 57S RNA was found "free" (ribonucleasesensitive) in the 2,000 x g supernatant fraction of disrupted cells. The nucleocapsid from detergent-disrupted Sendai virus and that from disrupted cells were indistinguishable in ultrastructure and buoyant density, and neither was found to be infectious or have hemagglutinating activity. Kinetic studies of nucleocapsid and virus formation indicated a relative block in conversion of viral nucleocapsid to complete enveloped virus in these cells, resulting in accumulation of large amounts of nucleocapsid in the cell cytoplasm. PMID- 4315965 TI - [Electromyography in the tarsal tunnel syndrome]. PMID- 4315966 TI - [A new product made of selfpolymerizing resin andquartz (Adaptic) as filling material]. PMID- 4315967 TI - [The intermediate lobe of the pituitary and its role in adaptation reactions]. PMID- 4315968 TI - [Peculiarities of the configuration of nucleic acids in viral particles]. PMID- 4315969 TI - Treatment of children with acute amoebic dysentery. Comparative trial of metronidazole against a combination of dehydroemetine, tetracycline, and diloxanide furoate. PMID- 4315970 TI - Adrenal cortical function in children on steroids. PMID- 4315972 TI - Sensory nerve conduction in lower extremities. PMID- 4315971 TI - Coincidence of congenital malformation and embryonic tumours of childhood. PMID- 4315973 TI - The catabolism of ethanolamine phospholipids in brain tissue. PMID- 4315974 TI - Free-radical intermediates in the reduction of oxygen. PMID- 4315975 TI - Initial steps in oxygen interaction with protein-bound metals. PMID- 4315976 TI - Co-operation of electron-accepting sites in oxygen reduction by oxidases. PMID- 4315978 TI - Evidence for the induction of a new deoxycytidine kinase in cells infected with herpes virus. PMID- 4315977 TI - Phosphatidic acid and phosphatidylinositol metabolism in Schizosaccharomyces pombe. AB - The phospholipid composition of Schizosaccharomyces pombe was not markedly affected by changes in the phosphate concentration of the medium or phase of growth. The major fatty acids in the total lipid extract and purified phosphatidylinositol were palmitic acid and oleic acid. Phosphatidic acid was synthesized by acylation of l-3-glycerophosphate in Schiz. pombe and phosphatidate phosphohydrolase was present. Phosphatidylinositol synthesis from inositol occurred in the absence of CDP-diglyceride. Even with dialysed cell-free preparations, the inositol lipid was synthesized by an apparently energy independent route, at rates greater than would be required during cell growth. Phosphatidylinositol appeared to be broken down by a phospholipase D. All the enzymes examined were particulate; similar activities were found in Saccharomyces cerevisiae. PMID- 4315979 TI - Cytochromes of ovary mitochondria: effect of human chorionic gonadotrophin. PMID- 4315980 TI - The effect of angiotensin II on the biosynthesis of aldosterone by ox adrenocortical tissue in continuous-flow experiments in vitro. PMID- 4315981 TI - Studies on adenyl cyclase and adenosine triphosphatase in rat corpus luteum. PMID- 4315983 TI - Toxicity of methylxanthines and local anaesthetics towards muscle. PMID- 4315982 TI - The stereochemistry of betulaprenol biosynthesis. AB - By using stereospecifically double-labelled radioactive mevalonates it was shown that betulaprenols-6 to -9, found in the woody tissue of Betula verrucosa, each contain three biogenetically trans-isoprene residues and that the remaining residues are biogenetically cis. The results obtained with these radioactive mevalonates also indicated that the activity of isopentenyl pyrophosphate isomerase is low relative to the activity of prenyltransferase in this woody tissue. The incorporation of radioactive farnesyl pyrophosphate and radioactive geranylnerol and the lack of incorporation of radioactive geranylgeraniol into betulaprenols-6 to -9 demonstrated that they are formed by the cis-additions of isoprene residues to all-trans-farnesyl pyrophosphate. PMID- 4315984 TI - [Effects of angiotensin on platelet aggregation]. PMID- 4315986 TI - Evidence that guanethidine does not block adrenergic nerves by acting as a false transmitter. PMID- 4315985 TI - [Inhibiting action of gliotoxin on the development of poliovirus I in vitro]. PMID- 4315987 TI - Circadian rhythm in plasma corticosterone concentration and pituitary adrenocorticotrophic response to stress in the betamethasone treated rat. PMID- 4315988 TI - Pituitary-adrenocortical activity in the ascorbic acid deficient guinea-pig. PMID- 4315989 TI - Release by amphetamine in man of growth hormone and corticosteroids: the effects of thymoxamine and propranolol. PMID- 4315990 TI - The action of angiotensin on the human colon in vitro. AB - 1. The action of angiotensin on the circular and longitudinal muscle of the human colon has been studied in vitro. The ED50 value (g/ml) of circular muscle was 8.7 x 10(-8) and of longitudinal muscle 3.1 x 10(-8), while the corresponding figures for acetylcholine were 1.6 x 10(-6) and 1.1 x 10(-6), respectively. Angiotensin caused a sustained contraction associated with prolonged tachyphylaxis.2. As the action of angiotensin was not antagonized by atropine, hexa-methonium or procaine, angiotensin appeared to act directly on the smooth muscle of the human colon.3. Lidoflazine is not a specific antagonist of angiotensin. PMID- 4315992 TI - Experimentally induced retinopathies in relation to the problem of diabetes. PMID- 4315991 TI - Localization of kininogenase in the rat kidney. AB - 1. The rat kidney kininogenase (KGA) activity was located mainly in the kidney cortex.2. Differential centrifugation of kidney cortex homogenate revealed that the microsomal fraction contained more KGA activity per unit of protein than the other subcellular fractions.3. Subfractionation of the microsomal fraction showed that the KGA activity was recovered in a subfraction also containing high specific activity of both alkaline phosphate and glucose-6-phosphatase. It is suggested that the KGA activity is localized in the plasma membrane and/or endoplasmic reticulum membranes of kidney cortical cells.4. Hydrolysis of N-alpha benzoyl-L-arginine ethyl ester at pH 8.5 paralleled the KGA activity. PMID- 4315993 TI - Treatment of isolated pulmonary metastases. PMID- 4315994 TI - Congenital dilatation of intrahepatic biliary ducts with cholangiocarcinoma. PMID- 4315995 TI - Platelet aggregation test with measles antigen in multiple sclerosis. AB - With the measles platelet aggregation test, a new technique recently developed for measuring virus antibody, 153 serum specimens from patients with multiple sclerosis and 164 controls were tested. With one of the three measles antigens used in the test a significantly higher positive rate (P<0.001) was obtained in the specimens from the patients with multiple sclerosis (40%) than in those from the controls (11%). The other two measles antigens also yielded slightly but not significantly higher positive rates in the patients with multiple sclerosis. PMID- 4315997 TI - [Bilateral Wilms' tumor (apropos of a case)]. PMID- 4315996 TI - Subclinical neuropathy in lead workers. AB - Evidence is presented for a minimal defect of peripheral nerve function in a group of lead accumulator workers without clinical evidence of a neurological lesion. Of the 19 men examined, 13 had blood levels above 80 mug./100 ml. and seven had haemoglobin levels below 12 g./100 ml., showing that considerable exposure to lead was occurring. PMID- 4315998 TI - [Studies on the Schneierson-Shore phenomenon]. PMID- 4315999 TI - Comparative analysis of mammary tissue and milk lipids of the sow. PMID- 4316000 TI - The synergistic action of the sulfonamides and the polymyxins against Serratia marcescens. PMID- 4316001 TI - Hunting common cold viruses by some new methods. PMID- 4316002 TI - [Insular myoblastoma granulocellulare in the pituitary stalk]. PMID- 4316003 TI - [Tumors with a mixed sarcomatous and glioma multiforme texture within 1 neoplastic area]. PMID- 4316004 TI - [Some problems of primary multifocal brain gliomas]. PMID- 4316005 TI - Hypophosphatemic osteomalacia associated with "nonendocrine" tumors. PMID- 4316006 TI - The response of superior sulcus tumors to radiation therapy. PMID- 4316007 TI - Evaluation of dilute pantopaque for large-volume myelography. PMID- 4316008 TI - [Acute respiratory tract diseases among military personnel. Etiologic aspects in 1965, 1966, 1967, 1968]. PMID- 4316009 TI - [Homicide followed by criminal incineration of the bodies of newborns. Medico legal considerations]. PMID- 4316010 TI - Activity of arylaminopeptidases, phosphatases, and L-cystine cleaving enzymes in normal and carious human dentine. PMID- 4316011 TI - Hydrolysis of phosphates by enzyme preparations derived from carious dentine, bacterial plaque and saliva. PMID- 4316012 TI - Efficient filtration and sizing of viruses with membrane filters. AB - Untreated membrane filters retain viruses by adsorption, as well as by physical restriction which occurs when the pore diameter of the filter is smaller than that of the virus particle. As originally recommended by Elford, membranes had to be pretreated with proteinaceous material to preclude virus adsorption. However, coating materials that prevent adsorption of certain viruses do not necessarily prevent adsorption of other viruses. In contrast to proteins, salts enhance virus adsorption. Viruses treated with sodium lauryl sulfate to reduce the surface tension, or purified viruses in distilled water, are not adsorbed to membranes. A procedure is recommended by which viruses may be passed through membranes with a porosity twice the diameter of the virus. Such filtrates, which contain 50 to 100% of the initial virus concentration, should be used for sizing viruses by subsequent filtration through smaller pores. The determination of virus size would then be based on the major population of particles in the virus suspension. In the past, as little as 0.1 to 0.001% of the initial virus population was the basis for size determination, because more than 99.9% of the virus was often lost by adsorption to membranes during the clarifying procedures. PMID- 4316013 TI - Herpesvirus envelopment. AB - The growth and envelopment processes of three representative herpesviruses, equine abortion, pseudorabies, and herpes simplex, were examined in baby hamster kidney (BHK 21/13) cells by bioassay (plaque-forming units) and electron microscopy. The envelopment process was identical for all three viruses. After assembly in the nucleus, the nucleocapsid acquired an envelope by budding from the inner nuclear membrane. This membrane was reduplicated as the enveloped particle was released so that the budding process did not result in disruption of the continuity of the nuclear membrane. That portion of the nuclear membrane which comprised the viral envelope was appreciably thicker than the remainder of the membrane and exhibited numerous projections on its surface. Once enveloped, the viral particles were seen in vesicles and vacuoles in the cell cytoplasm. These appeared to open at the cytoplasmic membrane, releasing the virus from the cell. There was no detectable difference in the size or appearance of enveloped particles in intra- or extracellular locations. PMID- 4316014 TI - Intracellular herpesvirus aggregate in the form of a pentagonal dipyramidal crystal-like structure. PMID- 4316015 TI - Preparation of herpes simplex virus of high titer. PMID- 4316016 TI - Biophysical studies on rhinovirus and poliovirus. I. Morphology of viral ribonucleoprotein. AB - An explanation has been sought for the high buoyant density of rhinoviruses, which are classified as acid-sensitive picornaviruses. Heat degradation of purified preparations of rhinovirus type 1B and poliovirus type LSc leads to the extrusion of ribonucleoprotein strands. Contour lengths of these strands were measured by electron microscopy, and the molecular weights of rhinovirus and poliovirus ribonucleic acid (RNA) were determined. Values of 2 x 10(6) and 4 x 10(6) daltons were obtained for the molecular weight of poliovirus and rhinovirus RNA, respectively. This additional nucleic acid in the rhinovirion probably accounts for the increased density and may be related to the acid sensitivity of the rhinovirus. PMID- 4316017 TI - Adenovirus transformation of hamster embryo cells. AB - Inoculation of hamster embryo cell cultures with human adenovirus type 12 (Ad12) or simian adenovirus (SA7) resulted in the formation of foci of morphologically transformed cells within 12 days. The rapid appearance of well-defined foci was dependent upon the transfer of cells into new plates, with sufficient dilution after virus adsorption, and was independent of virus dose. Dose-response studies showed linearity of focus formation with dilution of Ad12 or SA7. Results averaged from several experiments show plaque-forming unit to focus-forming unit ratios of approximately 1.8 x 10(6) for Ad12 and 2.6 x 10(5) for SA7. Other experiments showed that most of the adenovirus involved in transformation was adsorbed by 3 hr. Cell lines derived from SA7 transformed cells produced tumors within 19 days when inoculated intradermally into young adult hamsters. Such cell induced tumors histologically resembled SA7 virus-induced hamster tumors. Formation of tumors with SA7 transformed cells was inhibited by prior immunization of test animals with SA7 or Ad12 virus. PMID- 4316019 TI - Transformation of African green monkey kidney cells by irradiated adenovirus 7 simian virus 40 hybrid. AB - The ability of adenovirus 7-simian virus 40 (SV40) hybrid (strain LL "E-46") to replicate decreased exponentially as a function of the amount of gamma irradiation; the ability to induce SV40 and adenovirus 7 T antigen decreased at a much slower rate. Nevertheless, the virus was still able to transform African green monkey kidney cells at a radiation dosage that had completely destroyed its replication ability. All transformed colonies were positive for SV40 T antigen but were negative for adenovirus 7 T antigen. The adenovirus 7-SV40 hybrid transformed cells were superinfectible with SV40 virus. Two of the three transformed cell populations apparently did not sensitize hamsters against the appearance SV40 primary tumors, thus suggesting a deficiency in the SV40 transplantation antigen. PMID- 4316018 TI - Herpes simplex virus products in productive and abortive infection. II. Electron microscopic and immunological evidence for failure of virus envelopment as a cause of abortive infection. AB - Herpes simplex virus strain MPdk(-) multiplies in HEp-2 cells, but not in dog kidney (DK) cells. Strain MPdk(+)sp, a multistep mutant of MPdk(-), multiplies in both HEp-2 and DK cells. Stabilized lysates of productively infected cells yield three macromolecular aggregates of viral deoxyribonucleic acid and protein banding in CsCl gradients at densities of 1.285 g/cm(3) (alpha), 1.325 g/cm(3) (beta), and 1.37 to 1.45 g/cm(3) (gamma). Similar lysates from abortively infected cells yield only the beta and gamma bands. Electron microscopic examination revealed that (i) the alpha band contained enveloped nucleocapsids, whereas the beta band contained naked nucleocapsids and particles tentatively identified as internal components of the nucleocapsids, and that (ii) the enveloped virions and reduplication of cellular membranes observed in thin sections of productively infected cells were absent from abortively infected cells. Studies of the surface antigens of infected cells in a cytolytic system described previously revealed that abortively infected cells contained approximately 10-fold less virus-induced surface antigen than did productively infected cells. From these and other data published previously, we concluded that infectious MPdk(-) virions are not made in DK cells because (i) functional viral products necessary for the envelopment of the nucleocapsid are not made, and (ii) capsid proteins and some nonstructural products specified by the virus malfunction. PMID- 4316020 TI - Effect of arginine-deficient media on the herpes-type virus associated with cultured Burkitt tumor cells. AB - After incubation at 37 C for 2 or more days, Basal Medium Eagle (BME) supplemented with 25% fetal calf serum (FCS) was not able to support adequate growth of EB3 and other lines of Burkitt tumor cells. The medium did, however, increase, by a factor of about 10, the number of cells synthesizing herpes-type virus with which the cultures were persistently infected. Not every lot of FCS produced these effects, nor were these effects seen when BME and FCS were incubated separately for 7 days before the medium was completed. At 37 C, appropriate lots of FCS interacted with several of the amino acids present in BME; this interaction resulted in an inhibition of cellular growth, whereas interaction with arginine yielded the virus-enhancing effect. Arginine-free BME, supplemented with 25% FCS and used without prior incubation, prevented cellular replication and promoted viral infection to a similar extent as did preincubated complete medium. Replenishment of arginine reduced, but did not regularly abolish, the virus-enhancing activity of preincubated media. RPMI-1629 medium was less affected by preincubation with FCS because it contained twice the amount of arginine that BME contained. The FCS factors which act upon arginine and other amino acids are not dialyzable and are partially resistant to heating at 56 or 60 C for 30 to 60 min. Calf and horse sera appear to be devoid of these activities. The nature of these interactions, as well as the mechanism by which arginine deficiency enhanced the viral infection, remains to be ascertained. PMID- 4316021 TI - Production of virus by mammalian cells tranformed by Rous sarcoma and murine sarcoma viruses. AB - Cultured cells of mammalian tumors induced by ribonucleic acid (RNA)-containing oncogenic viruses were examined for production of virus. The cell lines were established from tumors induced in rats and hamsters with either Rous sarcoma virus (Schmidt-Ruppin or Bryan strains) or murine sarcoma virus (Moloney strain). When culture fluids from each of the cell lines were examined for transforming activity or production of progeny virus, none of the cell lines was found to be infectious. However, electron microscopic examination of the various cell lines revealed the presence of particles in the rat cells transformed by either Rous sarcoma virus or murine sarcoma virus. These particles, morphologically similar to those associated with murine leukemias, were found both in the extracellular fluid concentrates and in whole-cell preparations. In the latter, they were seen budding from the cell membranes or lying in the intercellular spaces. No viruslike particles were seen in preparations from hamster tumors. Exposure of the rat cells to (3)H-uridine resulted in the appearance of labeled particles with densities in sucrose gradients typical of virus (1.16 g/ml.). RNA of high molecular weight was extracted from these particles, and double-labeling experiments showed that this RNA sedimented at the same rate as RNA extracted from Rous sarcoma virus. None of the hamster cell lines gave radioactive peaks in the virus density range, and no extractable high molecular weight RNA was found. These studies suggest that the murine sarcoma virus produces an infection analogous to certain "defective" strains of Rous sarcoma virus, in that particles produced by infected cells have a low efficiency of infection. The control of the host cell over the production and properties of the RNA-containing tumorigenic viruses is discussed. PMID- 4316023 TI - Specificities of transport systems and enzymes. PMID- 4316024 TI - Bulk isolation in nonaqueous media of nuclei from lyophilized cells. AB - Intact lyophilized nuclei are obtainable from a variety of tissues, either in situ or in culture, by freezing at -156 degrees C, drying at -25 degrees C, and mechanical disassociation in glycerol at 2 degrees C. Centrifugal separation of nuclei is accomplished in an 85 : 15 by volume mixture of glycerol and 3-chloro 1,2 propanediol at 2 degrees C. The method gives homogeneous nuclear preparations in high yield with preservation of labile and water-soluble constituents. PMID- 4316022 TI - Characteristics of and relationship between C particles and intracisternal A particles in cloned cell strains. AB - Four murine tissue culture cell strains, which originated by cloning from one common cell of subcutaneous connective tissue origin, were examined for the presence of virus by electron microscopy and complement fixation techniques. The relative distribution of C particles and intracisternal A particles was determined. Thereafter, the characteristics of and relationship between A- and C type particles were investigated. Cell extracts were passaged onto virus-free Swiss and C3Hf mouse embryo tissue cultures; CF and EM tests were again made to investigate the infective capacities of the various particle types. Although C particles were found in passage cultures exposed to extracts from the C particle bearing strains, no A particles were found in any passage culture. These results indicate that the intracisternal A particle was neither infective nor developmentally associated with the C particle. A positive CF test was correlated with the presence of morphologically detectable C particles and was independent of the concentration of A particles. PMID- 4316026 TI - Alterations in virus distribution in mouse mammary carcinoma after irradiation, colchicine and androgen. PMID- 4316025 TI - Pyrazole and induction of fatty liver by a single dose of ethanol. AB - Pyrazole (4 millimoles per kilogram or 272 milligrams per kilogram of body weight), given to fasted rats 10 minutes before gavage with ethanol (4 grams per kilogram), completely prevented both the disappearance of ethanol from the blood over a 16-hour period and the ethanol-induced reduction in the ratio of oxidized to reduced hepatic nicotinamide-adenine dinucleotide. However, it did not affect the accumulation of triglycerides in the liver after the administration of ethanol. These results indicate that metabolism of ethanol is not required for production of fatty liver by a single, large dose of ethanol. PMID- 4316027 TI - Facilitation, inhibition and habituation of the vestibular responses. PMID- 4316028 TI - Orthodromic transmission of 8th nerve volleys through the vestibular nuclei during sleep. PMID- 4316029 TI - Some factors influencing the replicability of assessments of skeletal maturity (Greulich-Pyle). PMID- 4316030 TI - Differences in skeletal maturity levels between the knee and hand. PMID- 4316032 TI - Unusual renal masses in the pediatric age group. PMID- 4316031 TI - Correlation of angiography and isotope scanning in abdominal diseases of children. PMID- 4316033 TI - Presacral masses in childhood. PMID- 4316034 TI - [Inhibition of RNA-polymerase in poliovirus by guanidine]. PMID- 4316035 TI - [Influence of pH on the activity and electrophoretic migration of an ATP- and ADP phosphatase of the microsomal fraction of rat spleen]. PMID- 4316036 TI - [Transport of water in the small intestine of the rat]. PMID- 4316037 TI - Haematological changes in heat-acclimated golden hamsters. PMID- 4316038 TI - Presumed plasmacytoma of clivus producing isolated hypoglossal nerve palsy. PMID- 4316039 TI - Synthesis of corticotropin peptides. XI. Synthesis and biological properties of [1-beta-alanine]-ACTH(1-18)-octadecapeptide amide. PMID- 4316041 TI - [New studies on the active site of porcine heart lactate dehydrogenase]. PMID- 4316040 TI - Role of renin in acute postural homeostasis. PMID- 4316042 TI - The resolution of steps in heart and muscle lactate dehydrogenase reactions. PMID- 4316043 TI - [Regulation of heart muscle pyruvate dehydrogenase by enzymatic phosphorylation and dephosphorylation, and the participation of 3',5'-cyclo-AMP]. PMID- 4316045 TI - [The metabolite pair lactate-pyruvate as redox indicator]. PMID- 4316044 TI - [Molarities of glycolytic enzymes]. PMID- 4316046 TI - Hypoxia and lactate formation. PMID- 4316047 TI - [Effect of starvation, cortisol and insulin on the activities of pyruvate carboxylase, phosphopyruvate carboxylase (PEP-carboxykinase) and pyruvate kinase in the liver of NZo mice in various stages of diabetes]. PMID- 4316048 TI - [On the redox state of NAD-NADH systems in guinea pig liver under different experimental conditions]. PMID- 4316049 TI - Gluconeogenesis and redox state. PMID- 4316050 TI - Regulation of gluconeogenesis in rat and guinea pig liver. PMID- 4316051 TI - The effect of cyclic nucleotides on glucose synthesis in isolated rat kidney tubules. PMID- 4316052 TI - Transfer of carbon and hydrogen across the mitochondrial membrane in the control of gluconeogenesis. PMID- 4316053 TI - Studies on the effect of nucleoside cyclic 3',5'-monophosphates on antibody synthesis by spleen cells. PMID- 4316054 TI - [Isolation of Langerhans' islets from rat pancreas]. PMID- 4316055 TI - [Enzyme induction in Streptomyces hydrogenans. I. Criteria of enzyme induction]. PMID- 4316056 TI - [Interference in the test for phospho-2-keto-3-desoxyheptonate aldolase]. PMID- 4316057 TI - [A reversible cooperative conformational change of a synthetic DNA under the influence of high salt concentrations]. PMID- 4316058 TI - Long-term dietary management of dialysis patients. II. Composition and planning of the diet and patient education. PMID- 4316059 TI - Growth and caloric intake of heavy and tall children. PMID- 4316060 TI - Observations on latent bluetongue virus infection in cattle. PMID- 4316061 TI - Effect of temperature on growth of canine herpesvirus in canine kidney cell and macrophage cultures. PMID- 4316062 TI - Temperature as a factor in resistance of young puppies to canine herpesvirus. PMID- 4316063 TI - The influence of germ-free status and antilymphocyte serum on tumour development in mice exposed to chemical carcinogens. PMID- 4316064 TI - Hyperparathyroidism with local amyloid deposition. PMID- 4316065 TI - Studies of factors affecting gluconeogenesis and glycolysis in glycogenoses of the liver. PMID- 4316066 TI - A syndrome of pseudohermaphroditism, Wilms' tumor, hypertension, and degenerative renal disease. PMID- 4316067 TI - Common neurologic brachial pain problems. PMID- 4316068 TI - Neurologic complications in chronic renal failure. PMID- 4316069 TI - The pupil in neurologic diagnosis. PMID- 4316070 TI - Radioimmunoassay of serum chorionic gonadotropin and placental lactogen in trophoblastic disease. PMID- 4316071 TI - Krukenberg tumor of the ovaries. A review of 81 records. PMID- 4316072 TI - Inferior vena cava and ovarian vein ligation during late pregnancy. PMID- 4316073 TI - Virus infections during pregnancy. PMID- 4316074 TI - Inflammatory mammary cancer during pregnancy and lactation. Report of a case. PMID- 4316075 TI - [Neuropathies due to antituberculosis drugs]. PMID- 4316076 TI - [Late sequelae following intermittent positive-pressure respiration in severe idiopathic respiratory distress syndrome]. PMID- 4316077 TI - [Guillain-Barre-Strohl syndrome in children. Observation of 83 cases]. PMID- 4316079 TI - [The functioning of cortical neurons under the effects of non-synaptic (ephaptic) factor]. PMID- 4316080 TI - [Ultrahistochemical demonstration of periodate-reactive secretory substances in mouse Paneth cell granules]. PMID- 4316078 TI - [19S and 7S memory of mice after primary immunization with an immunogenic threshold dose of sheep erythrocytes]. PMID- 4316081 TI - [Use of tris-(hydroxymethyl)-aminomethane for the histochemical blockade of aldehydes]. PMID- 4316082 TI - [Case of methemoglobulinemia due to phenacetin]. PMID- 4316083 TI - [Microstructure of Wilms's tumor]. PMID- 4316085 TI - Activation of pain pathways in animals. PMID- 4316084 TI - [Activities of aminotransferases and phosphatases in experimental mercuric chloride poisoning in rabbits]. PMID- 4316087 TI - [Psychiatric care today]. PMID- 4316086 TI - Management of ovarian carcinoma, Surgery, irradiation, and chemotherapy. PMID- 4316088 TI - Cystosarcoma phyllodes in adolescent females. A report of seven patients. PMID- 4316089 TI - Paget's disease of the breast. PMID- 4316091 TI - The regulation of xanthine oxidase. Inhibition by reduced nicotinamide-adenine dinucleotide of rat liver xanthine oxidase type D and of chick liver xanthine dehydrogenase. AB - 1. Rat liver xanthine oxidase type D (NAD(+)-dependent) and chick liver xanthine oxidase are inhibited by NADH, which competes with NAD(+). 2. The addition of a NADH-reoxidizing system in the assay of these enzyme activities is proposed. 3. Rat liver xanthine oxidase type O (oxygen-dependent) is not affected by NADH. PMID- 4316090 TI - Effects of ischaemia on metabolite concentrations in rat liver. AB - 1. Changes in the concentrations of ammonia, glutamine, glutamate, 2 oxoglutarate, 3-hydroxybutyrate, acetoacetate, alanine, aspartate, malate, lactate, pyruvate, NAD(+), NADH and adenine nucleotides were measured in freeze clamped rat liver during ischaemia. 2. Although the concentrations of most of the metabolites changed rapidly during ischaemia the ratios [glutamate]/[2 oxoglutarate][NH(4) (+)] and [3-hydroxybutyrate]/[acetoacetate] changed equally and the value of the expression [3-hydroxybutyrate][2-oxoglutarate][NH(4) (+)]/[acetoacetate][glutamate] remained approximately constant, indicating that the 3-hydroxybutyrate dehydrogenase and glutamate dehydrogenase systems were at near-equilibrium with the mitochondrial NAD(+) couple. 3. The value of the expression [alanine][oxoglutarate]/[pyruvate][glutamate] was about 0.7 in vivo and remained fairly constant during the ischaemic period of 5min, although the concentrations of alanine and oxoglutarate changed substantially. No explanation can be offered why the value of the ratio differed from that of the equilibrium constant of the alanine aminotransferase reaction, which is 1.48. 4. Injection of l-cycloserine 60min before the rats were killed increased the concentration of alanine in the liver fourfold and decreased the concentration of the other metabolites measured, except that of pyruvate. During ischaemia the concentration of alanine did not change but that of aspartate almost doubled. 5. After treatment with l-cycloserine the value in vivo of the expression [alanine][oxoglutarate]/[pyruvate][glutamate] rose from 0.7 to 2.4. During ischaemia the value returned to 0.8. 6. The effects of l-cycloserine are consistent with the assumption that it specifically inhibits alanine aminotransferase. 7. Most of the alanine formed during ischaemia is probably derived from pyruvate and from ammonia released by the deamination of adenine nucleotides and glutamine. The alanine is presumably formed by the combined action of glutamate dehydrogenase and alanine aminotransferase. 8. The rate of anaerobic glycolysis, calculated from the increase in the lactate concentration, was 1.3mumol/min per g fresh wt. 9. Although the concentrations of the adenine nucleotides changed rapidly during ischaemia, the ratio [ATP][AMP]/[ADP](2) remained constant at 0.54, indicating that adenylate kinase established near equilibrium under these conditions. PMID- 4316092 TI - Effect of temperature acclimatization on the fatty acid composition of goldfish intestinal lipids. AB - 1. The fatty acid composition of whole goldfish, whole-intestinal mucosa, intestinal mucosal membranes and individual phospholipids extracted from mucosal membranes were measured, fish adapted to different temperatures being used. 2. Alterations of the adaptation temperature did not noticeably affect the fatty acid composition of the whole-fish lipids, but there were marked changes in the fatty acids of lipids extracted from homogenates of goldfish intestinal mucosa. These changes were more pronounced in a membrane fraction prepared from these homogenates. Raising the adaptation temperature by 20 degrees C halved the percentage of C(20:1), C(20:4) and C(22:6) fatty acids and nearly doubled the percentage of C(18:0) and C(20:3) fatty acids recovered. 3. Choline phosphoglycerides constituted about one-half and ethanolamine phosphoglycerides about one-quarter of the total membrane phospholipids. 4. The fatty acids of choline and ethanolamine phosphoglycerides were more susceptible to temperature dependent changes than were the phosphoglycerides of inositol or serine. 5. The increase in C(18:0) fatty acid that occurred in membranes of warm-adapted fish was greatest for ethanolamine phosphoglycerides, but increases also occurred in other phospholipid fractions and in membrane neutral lipids. PMID- 4316093 TI - Enzymatic activities of the matrix and inner membrane of pigeon-liver mitochondria. PMID- 4316094 TI - Studies of FAD and NADH in the presence of N1-dodecyl-nicotinamide chloride micelles. PMID- 4316095 TI - Some properties of a nitrate reductase from Pseudomonas denitrificans. PMID- 4316096 TI - A simple micro method for the direct determination of delta-amino (14C) levulinic acid production in murine spleen and liver homogenates. PMID- 4316097 TI - Effect of aging on the adenyl cyclase and phosphodiesterase activity of isolated fat cells of rat. PMID- 4316098 TI - Radiation and the phagocytic function of the reticuloendothelial system. II. Mechanism of RES stimulation after irradiation. PMID- 4316099 TI - Growth of viruses in organ cultures of intestine. PMID- 4316100 TI - [A lacrimal gland mixed tumor with malignant finding]. PMID- 4316101 TI - Feeding studies on sodium cyclamate, saccharin and sucrose for carcinogenic and tumour-promoting activity. PMID- 4316103 TI - Effect of temporary denervation on the develop- ment of the acetylcholinesterase positive structures of the rat myoneural junction. PMID- 4316102 TI - Effects of phase transitions on enzymes bound to different cellular membranes. PMID- 4316105 TI - Characterization of antisera for human follicle-stimulating hormone radioimmunoassay. PMID- 4316104 TI - [Enzyme-histochemical studies on the mammary gland. Pregnancy, lactation, involution and experimental obstruction, with special attention to myoepithelial cells]. PMID- 4316107 TI - A surface enzyme in Hymenolepis diminuta (cestoda). PMID- 4316106 TI - Lipolysis by human adipose tissue: the role of cyclic 3',5'-adenosine monophosphate and adrenergic receptor sites. PMID- 4316108 TI - [The effect of restricted food intake on the glucose and lipid metabolism in obese-hyperglycemic mice]. PMID- 4316109 TI - [Homocytotrophic antibody in rats]. PMID- 4316110 TI - The effect of intravenous antirenin injection on chronic experimental and acute renin-induced hypertension in dogs. PMID- 4316111 TI - The effect of immunity to renin on the renal response to saline infusions in dogs. PMID- 4316112 TI - Type 3 glycogenosis. A biochemical and electron microscopic study. PMID- 4316113 TI - [Effect of the chain length of oligonucleotides on interferon induction]. PMID- 4316114 TI - The effect of neurohumoral drugs on the fixation of spinal reflexes and the incorporation of uridine into the spinal cord. PMID- 4316115 TI - [Tuberculosis and immune deficiencies. 2 cases]. PMID- 4316116 TI - [Clinical and paraclinical diagnosis of arteriovenous fistulas of the limbs]. PMID- 4316117 TI - [Study of toxoplasmosis in Caen C.H.U. Results of a systematic serologic inquiry]. PMID- 4316118 TI - [Normal and pathological strontium 85 tests. Application in cancerology]. PMID- 4316119 TI - [Continuous treatment with diazoxide of hypoglycemia due to hyperinsulinism]. PMID- 4316120 TI - [How to oversee the treatment of tuberculosis?]. PMID- 4316121 TI - Viruslike particles in human breast cancer. PMID- 4316122 TI - Treatment of varicella-zoster with cytosine arabinoside. PMID- 4316123 TI - Continuous fasciculations, myokymia and muscle contraction due to peripheral nerve disease. PMID- 4316124 TI - [Enzymes of amniotic fluid]. PMID- 4316126 TI - Malignant synovioma. PMID- 4316125 TI - [The origin of amniotic fluid enzymes]. PMID- 4316127 TI - [Intestinal invagination due to a benign tumor of the small intestine. Schwannoma and histiocytofibroma]. PMID- 4316128 TI - [Study of 600 strains of isolated staphylococci in current bacteriological practice]. PMID- 4316129 TI - Sperm antibodies and their action upon human spermatozoa. PMID- 4316130 TI - [Disseminated cryptococcosis revealing hepatoma and cancer of the kidney]. PMID- 4316131 TI - [Jugular glomus and its tumors]. PMID- 4316132 TI - [Results of the section of Jacobson's nerve and tympanic chorda parotid diseases and their sequelae]. PMID- 4316133 TI - [Glomus and false glomus (4 cases)]. PMID- 4316134 TI - [Somatic future of children with kwashiorkor]. PMID- 4316135 TI - [Neonatal hypoglycemia]. PMID- 4316136 TI - [Radiological study of the wrist in phenylketonuria. 23 cases]. PMID- 4316137 TI - [Action of periodic acid on perseulose]. PMID- 4316139 TI - [Presence of specific "repressor" in hamster or rat cells transformed by polyoma virus]. PMID- 4316138 TI - [Electron microscopy of an inflammatory reaction in rabbit's cornea. II. Changes in collagen: edema, collagenolysis, fibrillogenesis]. PMID- 4316140 TI - [Morphology and endocrine function of the rat pancreas in an organ culture system]. PMID- 4316141 TI - [Hormone sensitive lipase]. PMID- 4316142 TI - [Cylindromas of upper respiratory and digestive tract]. PMID- 4316143 TI - The Oklahoma City child disappearances of 1967: forensic anthropology in the identification of skeletal remains. PMID- 4316144 TI - Titration of cholera enterotoxin and antitoxin in isolated fat cells. PMID- 4316145 TI - The relation between the persistence of El Tor vibrio in the intestines of germfree mice and so-called coproantibody. PMID- 4316146 TI - Infectious-mononucleosis-like disease with negative heterophil agglutination test. Clinical features in relation to Epstein-Barr virus and cytomegalovirus antibodies. PMID- 4316147 TI - Age-related cellular resistance of the chicken embryo to viral infections. I. Interferon and natural resistance to myxoviruses and vesicular stomatitis virus. PMID- 4316148 TI - Age-related cellular resistance of the chicken embryo to viral infections. II. Inducible resistance produced by influenza virus and Escherichia coli. PMID- 4316149 TI - A mutant of Parainfluenza type 1 virus with decreased capacity for growth at 38 C and 39 C. PMID- 4316151 TI - Glycolytic and cytochrome oxidase activity in Plasmodia. PMID- 4316150 TI - [Intrarenal action of angiotensin]. PMID- 4316152 TI - Cytochrome oxidase activity in a normal and some drug-resistant strains of Plasmodium berghei--a cytochemical study. I. Asexual erythrocytic stages. PMID- 4316154 TI - [Importance of the Hoffmann H response in lesions of the 1st sacral root caused by herniated disk (preliminary note)]. PMID- 4316153 TI - [Course of silicosis in porcelain manufacture workers of Limousin between 1948 and 1968]. PMID- 4316155 TI - [Does the posterior cervical sympathetic syndrome, so-called "Barre-Lieou syndrome", exist?]. PMID- 4316156 TI - [Articular manifestations of Takayasu's disease]. PMID- 4316157 TI - [Osteo-articular manifestations of acromegaly]. PMID- 4316158 TI - [Doege-Potter syndrome. Clinical and anatomo-pathological data]. PMID- 4316159 TI - [Biology and physiopathology of Doege-Potter syndrome]. PMID- 4316160 TI - [Nadler-Wolfer-Elliot syndrome (hypoglycemic hepatoma)]. PMID- 4316161 TI - [Anderson's syndrome]. PMID- 4316162 TI - [Duodenal ulcer and accessory pancreatitis. Sever hemorrhage triggered off by contact with aspirin]. PMID- 4316163 TI - [Karyotyping]. PMID- 4316164 TI - [Kahlbaum's catatonia, schizophrenia and revision of psychiatric nosography]. PMID- 4316165 TI - [Role of rickettsiosis and neo-rickettsiosis in obstetrical pathology]. PMID- 4316166 TI - [Liver and Hodgkin's disease]. PMID- 4316167 TI - The neurophysiologic principles of the Andresen method of functional jaw orthopedics. A critical analysis and new hypothesis. PMID- 4316168 TI - [Transmission of fowl pox virus by Persian ticks]. PMID- 4316169 TI - The human corpus luteum of pregnancy with reference to the state of the trophoblastic tissue. A histological, histochemical and biochemical study. PMID- 4316170 TI - Synergistic effect in viral-bacterial infection. 2. Influence of viral infection on the phagocytic ability of alveolar macrophages. PMID- 4316171 TI - [Activities of oxidoreductases and phosphatases in the synapse]. PMID- 4316172 TI - [Inhibitory transmitter of cerebellar Purkinje cells]. PMID- 4316173 TI - [Release of chemical transmitters in the brain]. PMID- 4316174 TI - Serratia marcescens keratoconjunctivitis. PMID- 4316175 TI - Pathogenetic approach to therapy of peripheral corneal inflammatory disease. PMID- 4316176 TI - Electromyographic evidence of some control factors involved in the acquisition of skilled performance. PMID- 4316177 TI - The effect of nasal and nasopharyngeal irritation on airway resistance in man. PMID- 4316178 TI - Empyema caused by Clostridium perfringens. PMID- 4316179 TI - [Intra-hepatic cholestasis by obstruction of interlobular biliary ducts during generalized disease of cytomegalic inclusions in the newborn]. PMID- 4316180 TI - [Growth of children with craniopharyngioma. Growth speed and results of determinations of blood growth hormone before and after surgery]. PMID- 4316181 TI - [Craniopharyngioma. Recovery of growth after surgery in spite of somatotropin deficiency]. PMID- 4316182 TI - Evidence for cyclic-3',5'-adenosine monophosphate as chemotactic agent for polymorphonuclear leukocytes. PMID- 4316183 TI - [Autopsy case of liver cancer undetected until the terminal stage]. PMID- 4316184 TI - Addison's disease due to reticulum-cell sarcoma apparently confined to the adrenals. PMID- 4316185 TI - [Clinical trial of a new anti-inflammatory and anti-infectious otologic drugs: stapolidex]. PMID- 4316186 TI - The rat fat-free body in middle life: continuing growth and histochemical changes. PMID- 4316187 TI - A study of some selected trace elements in normal and cancerous tissue by neutron activation analysis. PMID- 4316188 TI - [Treating severe arterial insufficiency in the legs by induced hypertension]. PMID- 4316189 TI - [On a tumor with theca cells and granulosa cells in pregnancy]. PMID- 4316190 TI - [Chromosome changes induced by viruses in human cells]. PMID- 4316191 TI - [Chromosome abnormalities following leukemia virus action in mice]. PMID- 4316192 TI - [Chromosome abnormalities caused by DNA oncogenic viruses on animal cells]. PMID- 4316194 TI - [Some current data concerning the mechanism of action of insulin]. PMID- 4316193 TI - [Adenyl-cyclase system in the distribution of energy]. PMID- 4316196 TI - [The interrelationship between the adrenal cortex and the thyroid gland]. PMID- 4316195 TI - [Hybrids of malignant and normal cells]. PMID- 4316197 TI - [Hepatocellular changes in liver biopsy in chronic lead poisoning in man]. PMID- 4316198 TI - Primary infection with human cytomegalovirus: virus isolation from healthy infants and pregnant women. PMID- 4316200 TI - Analysis of serum pooling schemes for identification of large numbers of viruses. PMID- 4316199 TI - Prevalence of antibody against viruses in the Tiriyo, an isolated Amazon tribe. PMID- 4316201 TI - Experimental reovirus infection in monkeys. I. Clinical and virological studies. PMID- 4316202 TI - [Malignant abdominal tumors in childhood: diagnosis and treatment in 134 cases]. PMID- 4316203 TI - [Structure and function of the granular nuclear bodies. Investigation on the squamous cell carcinoma]. PMID- 4316204 TI - Affinity of ventricular 99mTc pertechnetate and iodide ions for choroid plexus. PMID- 4316205 TI - A cyclic-3',5'-adenosine monophosphate dependent protein kinase from the adrenal cortex: comparison with a cyclic AMP binding protein. PMID- 4316206 TI - The effect of amino acids on the ability of cyclic AMP to reverse catabolite repression in Escherichia coli. PMID- 4316207 TI - A second form of energy transfer factor B and a new factor (factor C) of mitochondrial oxidative phosphorylation. PMID- 4316208 TI - A complex of mitochondrial factor A and a new factor involved in oxidative phosphorylation. PMID- 4316209 TI - The redox potential of liver cytochrome P-450. PMID- 4316210 TI - Complexes of polyoma DNA and synthetic polyribonucleotides. PMID- 4316211 TI - Biochemical properties of a nuclear thermosensitive mutant of Saccharomyces cerevisiae. PMID- 4316212 TI - Relation between conformations and activities of lipoamide dehydrogenase. IV. Apoenzyme structure and flavin binding aspects. PMID- 4316213 TI - Metabolism of naturally occurring homopolymers. II. Characterization of adenine rich polynucleotides of mouse liver ribosomes. PMID- 4316214 TI - Studies on the intracellular and intramitochondrial distribution of A 5' endonuclease in regenerating rat liver. PMID- 4316215 TI - Chromatography of nuclear 4-7-S RNA on DEAE-sephadex columns. PMID- 4316216 TI - [Multiple glomus tumor]. PMID- 4316217 TI - [The problem of wart therapy. I. Practical review of current methods. II. Own comparative study on the use of liquid nitrogen and sharp spoon in 298 cases]. PMID- 4316218 TI - Spontaneous activity in the cardioaccelerator nerves of the crayfish, Astacus pallipes lereboullet. PMID- 4316219 TI - [A case of narcolepsy associated to Kilayditi syndrome. Its comparison with Pickwick syndrome]. PMID- 4316220 TI - Feedback regulation of adrenocorticotropin secretion in "basal" and "stress" conditions: acute and chronic effects of intrahypothalamic corticoid implantation. PMID- 4316221 TI - Role of the baroreceptor reflexes and vasoactive polypeptides in the corticotropin release evoked by hypotension. PMID- 4316222 TI - Effect of dibutyryl-3',5'-AMP, theophylline and norepinephrine on lipolytic action of growth hormone and glucocorticoid in white fat cells. PMID- 4316223 TI - Urinary estrogen excretion after ACTH in ovariectomized monkeys (Macaca mulatta). PMID- 4316224 TI - Pseudo-traumatic epilepsy. PMID- 4316226 TI - Inactivation and heat stabilization of poliovirus by 2-thiouracil. AB - Treatment of poliovirus Type I with 10(-3)m 2-thiouracil (2-TU) resulted in the inactivation of greater than 90% of the virus infectivity and stabilization of approximately 50% of the residual virus to heat inactivation. These effects were due to a reaction with the protein moiety of the virus and could be blocked by pre-treatment of the virus with l-cystine or of the drug with cysteine. Both inactivation and stabilization occurred synchronously and reached equilibrium at the same time. Neither process was reversed by reducing agents. It is suggested that an oxidized form of 2-TU reacts with capsid sulfhydryl groups to form a product which is stable in either the inactive or heat-resistant form. PMID- 4316225 TI - Effect of acute hypoxia on vascular responsiveness in man. I. Responsiveness to lower body negative pressure and ice on the forehead. II. Responses to norepinephrine and angiotensin. 3. Effect of hypoxia and hypocapnia. AB - An effect of hypoxemia on vascular responsiveness and blood pressure regulation has not been demonstrated in man. The response of forearm resistance vessels to several vasoconstrictor stimuli was compared during normoxia and acute hypoxia. Forearm vasoconstrictor responses to lower body negative pressure and to the application of ice to the forehead, which are neurogenic stimuli, were decreased during acute hypoxia. Lower body negative pressure caused a decrease in mean arterial pressure during hypoxia, but not during normoxia. Because norepinephrine is the neurotransmitter released during reflex vasoconstriction, we considered the possibility that decreased responsiveness to norepinephrine might be one mechanism for diminished responses to lower body negative pressure and ice on the forehead during hypoxia. Hypoxia decreased the response of forearm resistance vessels to infusions of norepinephrine and angiotensin into the brachial artery. In addition, the effectiveness of intravenous infusions of norepinephrine in elevating mean arterial pressure was decreased during hypoxia. Since exposure to acute hypoxia stimulates hyperventilation and hypocapnia, experiments were done to determine the contribution of hypocapnia during hypoxia to the decreased vasoconstriction. The results indicate that hypocapnia may diminish the vascular response to some stimuli, but the reduction in oxygen appears to be the primary mechanism for decreased vasoconstrictor responses during acute hypoxia. PMID- 4316227 TI - Nonidentiy of some simian virus 40-induced enzymes with tumor antigen. AB - The complement-fixing tumor (T) antigen induced by simian virus 40 (SV40) has been prepared from SV40-infected cell cultures, from infected cell cultures treated at the time of infection with 1-beta-d-arabinofuranosylcytosine (ara-C), and from SV40-transformed cells. Upon partial purification, the T antigen exhibited the following properties: it was tightly adsorbed by calcium phosphate gel, it was precipitated by acetic acid at pH 5 or by ammonium sulfate at about 20 to 32% saturation, and it had a molecular weight greater than 250,000, as estimated by Sephadex G-200 gel chromatography. In contrast, deoxycytidylate (dCMP) deaminase, thymidylate (dTMP) kinase, and thymidine (dT) kinase were less strongly bound to calcium phosphate and were not precipitated at pH 5; these enzymes also had much lower molecular weights than the T antigen, as did dihydrofolic (FH(2)) reductase. Furthermore, higher ammonium sulfate concentrations were required to precipitate dCMP deaminase, dTMP kinase, and FH(2) reductase activities than to precipitate the T antigen. Another difference was that the T antigen was not stabilized, but dCMP deaminase, dTMP kinase, and dT kinase, were stabilized, respectively, by dCTP, dTMP, and dT or dTTP. Deoxyribonucleic acid (DNA) polymerase activity resembled the T antigen in adsorption to calcium phosphate, in precipitation by ammonium sulfate or at pH 5, and in the rate of inactivation when incubated at 38 C. However, the polymerase activity could be partly separated from the T antigen by Sephadex G-200 gel chromatography. The cell fraction containing partially purified T antigen also contained a soluble complement-fixing antigen (presumably a subunit of the viral capsid) which reacted with hyperimmune monkey sera. The latter antigen was present in very low titers or absent from cell extracts prepared from SV40 infected monkey kidney cell cultures which had been treated with ara-C at the time of infection, or from SV40-transformed mouse kidney (mKS) or hamster tumor (H-50) cells. The T antigen, however, was present in usual amounts in SV40 transformed cells or ara-C treated, infected cells. PMID- 4316228 TI - Comparative studies of the regeneration of HeLa cell receptors for poliovirus T1 and coxsackievirus B3. AB - Enterovirus receptors of live HeLa cells have been shown to reappear after inactivation by proteolytic enzymes, provided the cells are incubated at 37 C in a nutritionally adequate medium. Regeneration of receptor activity for poliovirus T1 occurred at a significantly faster rate than for coxsackievirus B3. The regenerative process for both types of receptors studied evidently required an active process of protein synthesis, since it was found that reappearance of receptor activity was inhibited by streptovitacin A, puromycin, and actinomycin D. Substitution of p-fluorophenylalanine for the naturally occurring amino acid, at concentrations which inhibited virus synthesis, was without effect on regeneration of receptor activity. It is anticipated that these findings will aid in the study of the biosynthesis and subsequent chemical characterization of viral receptors of living host cells. PMID- 4316229 TI - Nonproducing state of Rous sarcoma cells: its contagiousness in chicken cell cultures. AB - Nonproducing Rous sarcoma cells of the chicken were capable of transmitting the Rous sarcoma virus genome to neighboring chick embryo fibroblasts. This transfer required close proximity of sarcoma and normal cells and may have been mediated by a subcellular infectious agent which was found to be released from nonproducing cells. PMID- 4316230 TI - Induction of cellular deoxyribonuleic acid synthesis by simian virus 40. AB - The incorporation of (3)H-thymidine ((3)H-dT) into deoxyribonucleic acid (DNA) has been studied in uninfected confluent monolayer cultures of monkey kidney and mouse kidney cells, simian virus 40 (SV40)-infected cells, and in SV40 transformed mouse kidney cells. Radioautographic measurements revealed that during the period from 28 to 51 hr after productive SV40 infection of monkey kidney cultures about 80% of the cells synthesized DNA, compared to about 16% in uninfected cultures. At 28 to 43 hr after abortive SV40 infection of mouse kidney cultures, 24 to 37% of the cells synthesized DNA, compared to about 6 to 8% in uninfected cultures. The infected monkey kidney and mouse kidney cultures, respectively, incorporated about 5 to 10 times and 3 to 5 times as much (3)H-dT into DNA as did uninfected cultures. Moreover, the net DNA synthesized by SV40 infected monkey kidney cultures, estimated by colorimetric methods, substantially exceeded that of uninfected cultures. Nitrocellulose chromatography and band centrifugation experiments were performed to elucidate the kinds of DNA synthesized in the cultures. In uninfected monkey kidney cultures and at 2 to 12 hr after SV40 infection, almost all of the (3)H-dT labeled DNA sedimented more rapidly than SV40 DNA, and the radioactive DNA was denatured by heating for 12 min at 100 C (cellular DNA). Almost all of the labeled DNA obtained from abortively infected mouse kidney cultures and from SV40-transformed cells also had the properties of cellular DNA. However, approximately one-third to one-half of the labeled DNA obtained from monkey kidney cultures 28 to 51 hr after infection sedimented more slowly than cellular DNA and was not denatured by the heating (SV40 DNA). It is concluded that cellular DNA synthesis was induced during either the productive or abortive SV40 infections. PMID- 4316231 TI - Comparative study of cultured Burkitt tumor cells by immunofluorescence, autoradiography, and electron microscopy. AB - Cultured Burkitt cells were examined by immunofluorescence, autoradiography, and electron microscopy in an effort to identify the stainable cells with those harboring herpes-type virus particles. Immediately after a 2-hr pulse of (3)H thymidine, from 30 to 60% of the cells revealed heavy nuclear labeling. In most cases the grains were evenly dispersed, but in about 3 to 5% the grains showed a focal distribution and occasionally they extended into the cytoplasm. Such nuclear foci were rarely seen at 8 hr after the pulse. When the analysis was restricted to preselected immunofluorescent cells, up to 80% showed label at 8 hr and cytoplasmic grains were prominent. To reduce cellular deoxyribonucleic acid (DNA) synthesis, cells were X-irradiated with 3,000 to 6,000 R, and the isotope pulse was applied 1, 4, or 7 days later. Whereas the total number of labeled cells decreased in roughly twofold steps at the respective intervals (from 40 to 10%), the incorporation of (3)H-thymidine into fluorescent cells was not affected by X irradiation. In each series, about 70% of the fluorescent cells contained label when they were examined at 24 and 48 hr after the pulse, whereas at 8 and 72 hr fewer were positive. At the earlier intervals, unlabeled fluorescent cells most likely represented cells which had completed viral DNA synthesis prior to the pulse; at the later intervals, unlabeled fluorescent cells were probably cells which commenced viral replication after the pulse. These data support the conclusion that the immunofluorescent cells are the ones which harbor virus, and also confirm the expectation that the virus is a DNA virus from a member of the herpes group. This conclusion was firmly established by sectioning and electron microscopic examination of individual fluorescent cells, all of which contained numerous virus particles, whereas the nonstained cells prepared in a similar manner were free of them. PMID- 4316232 TI - Enhancement of the replication of human adenoviruses in simian cells by simian adenovirus SV15. PMID- 4316233 TI - Massive direct conversion of chick embryo cells by strain MC29 avian leukosis virus. PMID- 4316234 TI - Purification of T antigen from nuclei of simian virus 40-induced hamster tumors. PMID- 4316235 TI - Effects of poliovirus and of guanidine on the metabolism of glycogen in HeLa cells. PMID- 4316236 TI - Characterization of the strain of adenovirus type 7 carrying the defective monkey cell-adapting component. AB - The strain of adenovirus type 7 carrying the defective monkey cell-adapting component (MAC) has been further characterized. MAC is more sensitive to inactivation by ultraviolet light than the associated adenovirus, which, in turn, is more rapidly inactivated than complete simian virus 40 (SV40). The 37% dose was 16 sec for MAC, 60 sec for adenovirus, and 84 sec for SV40. Filtration through membranes revealed that both MAC and adenovirus were retained by 100-mmu filters. MAC equilibrated in cesium chloride at the same buoyant density as the complete adenovirions (1.34 g/ml). Deoxyribonucleic acid extracted from green monkey kidney cells infected with MAC-adenovirus 7 did not hybridize in vitro with SV40 complementary ribonucleic acid. The two components (MAC and adenovirus) of the virus population possess such similar biophysical properties that their separation has not yet been achieved. Evidence to date indicates that MAC is probably not derived from SV40. PMID- 4316237 TI - Factors influencing the enhancement of the infectivity of poliovirus ribonucleic acid by diethylaminoethyl-dextran. AB - The enhancement by diethylaminoethyl-dextran (DEAE-D) of the infectivity of poliovirus ribonucleic acid (RNA) for cell cultures was demonstrated by infective center as well as by plaque assays, both in nonprimate (L) and primate cell systems (MK, HeLa, LLC-MK(2)). The sensitivity of plaque assays was greatly improved by using a tris (hydroxymethyl)aminomethane-buffered synthetic medium (basal medium Eagle) and freshly confluent cell monolayers. Enhancement of nucleic acid infectivity was directly dependent on the molecular weight of the DEAE-D. Two observations bearing on the action of DEAE-D appeared important: ribonuclease activity was reduced by DEAE-D, and cells pretreated with DEAE-D remained susceptible to infection with RNA in isotonic medium. Appreciable susceptibility of the treated cells persisted for at least 2 hr; the susceptible state could be reversed at will by an application of heparin. Enhancement of nucleic acid infectivity was independent of an effect of DEAE-D on intact virus and agar inhibitors. PMID- 4316238 TI - Two loci controlling genetic cellular resistance to avian leukosis-sarcoma viruses. AB - Female chickens known to be heterozygous for resistance to subgroups A and B of the avian leukosis-sarcoma viruses were mated to males known to be homozygously resistant to both. The progeny were assayed both on the chorioallantoic membrane (CAM) and in tissue culture for resistance to representative viruses of the A, B, and tentatively defined C subgroups. Segregation ratios of resistance to A and B subgroup viruses agreed with the previously suggested hypothesis of single autosomal-recessive genes controlling resistance to each subgroup. Mixed infection on the CAM and replicate plate infection in tissue culture with subgroup A and B viruses showed that resistance to the A and B subgroups was inherited independently. Assays with viruses tentatively classified as subgroup C indicated that they were largely composed of a mixture of subgroup A and B viruses or of particles possessing the host range specificity of both. However, virus stocks of the subgroup C category, as well as some stocks classified as subgroup B, produced small numbers of pocks or foci on individuals known to be resistant to subgroup A and B viruses. It is suggested that these Rous sarcoma virus stocks carry between 1 and 10% of a true subgroup C virus. PMID- 4316239 TI - Analysis of hamster tumor cell lines isolated from single colonies soon after induction by polyoma strains differing in transplant antigen production. AB - Tumor cell colonies, arising after the infection of hamster embryo cells with two strains of polyoma virus (PV) which differed in their capacity to induce the PV specific transplant antigen, were isolated and studied for their transplant and tumor or "T" antigen content and growth characteristics in vitro and in vivo. Four of four tumor lines induced by the transplant immunogenic 3049 strain contained the transplant antigen, while only one of seven lines induced by the immunogenically deficient sp-D strain showed direct evidence for this antigen. T antigen was not detected by immunofluorescence in three tumor lines induced by the 3049 virus which contained the polyoma transplant antigen. No differences in growth capacity on plastic, in agar, or in the hamster subcutaneous tissue were apparent in spite of significant differences in transplant antigen content among the clones. PMID- 4316240 TI - Thymidine kinase from normal, simian virus 40-transformed and simian virus 40 lytically infected cells. AB - Simian virus 40 (SV40) infection of human diploid cells failed to cause an enhanced production of thymidine kinase during the first 10 days after infection. Thymidine kinase activities from extracts of SV40-transformed cultures (human or simian) were considerably higher than the activity levels in extracts from the normal cells of origin. In addition, whereas the kinase activities obtained for human diploid cultures decreased as the cell sheet became confluent, the kinase activities for SV40-transformed human cells remained high after confluence was reached. Antisera obtained from hamsters bearing SV40 or adeno-7-SV40 hybrid virus tumors selectively inhibited enzyme from transformed sources (human or simian). Also, the antisera selectively inhibited enzyme extracted from SV40 lytically infected monkey cells. Sera from normal animals or from hamsters bearing polyoma tumors failed to inhibit enzymes from normal, SV40-transformed, or SV40-lytically infected cells. The Michaelis constant of partially purified enzyme from SV40-transformed cells was two to five times as high as that obtained for partially purified enzyme from human diploid cell cultures. PMID- 4316241 TI - Virogenic properties of bromodeoxyuridine-sensitive and bromodeoxyuridine resistant simian virus 40-transformed mouse kidney cells. AB - When simian virus 40 (SV40)-transformed mouse kidney cells (mKS) were grown in the presence of susceptible indicator cells, SV40 was readily recovered from: (i) 15 transformed cell lines, (ii) transformed cells subcultured 45 times over a 7 month period in medium containing antiviral serum and bromodeoxyuridine (dBU), (iii) 45 of 46 clonal lines isolated in the presence of antiviral serum, (iv) 19 of 19 secondary clones isolated from two clonal lines, and (v) dBU-resistant transformed cell lines. dBU-resistant SV40-transformed mouse kidney cell lines were selected and shown to contain the T antigen and to have normal levels of thymidylate kinase and deoxyribonucleic acid (DNA) polymerase, but to be deficient in thymidine (dT) kinase. Radioautographic and biochemical experiments demonstrated that very little (3)H-dT was incorporated into DNA of dBU-resistant cells during a 6-hr labeling period. After infection of dT kinase-deficient mKS cells with vaccinia virus, high levels of dT kinase were induced. The properties of SV40 recovered from dBU-sensitive and dBU-resistant cells were studied. SV40 recovered from transformed cells was shown to express in CV-1 cells at least six functions characteristic of parental virus: synthesis of capsid antigen, synthesis of T antigen, synthesis of viral DNA, induction of dT kinase, induction of DNA polymerase, and induction of host cell DNA synthesis. In addition, SV40 recovered from the transformed cells induced T antigen, dT kinase, deoxycytidylate deaminase, thymidylate kinase, and DNA polymerase in abortively infected mouse kidney cultures, and the virus was also capable of transforming primary cultures of mouse kidney cells. PMID- 4316242 TI - Effect of polycations on growth and dissemination of the encephalomyocarditis virus in mice. AB - Pathogenicity of the encephalomyocarditis (EMC) virus for adult mice was increased when polycations of diverse type were mixed with virus and inoculated by the subcutaneous or intraperitoneal routes. Diethylaminoethyl (DEAE) dextran, hexadimethrine (polybrene), polymyxin B, polylysine, and calf thymus histone in various concentrations stimulated multiplication of virus in tissues at the injection site and enhanced entry of virus into the blood. The nonpathogenic r(+) variant of EMC which grows locally in tissues but fails to disseminate after subcutaneous and intraperitoneal inoculation was used in most experiments. This virus caused viremia and fatal central nervous system disease only when the polycations were included in the inoculum. DEAE dextran and polybrene stimulated the release of interferon in infected tissues but had no effect in the absence of virus multiplication. Histological studies of tissues from the injection site showed that polycations provoke a mononuclear cell reaction and alter the integrity of connective tissue. However, the mechanism by which the substances enhance virus growth and dissemination was not defined. PMID- 4316243 TI - Transformation of simian virus 40-resistant hamster cells with an adenovirus 7 simian virus 40 hybrid. AB - When the hamster cell lines BHK21 and Nil-2 were infected at a multiplicity of 100 with the adenovirus 7-simian virus 40 (SV40) hybrid (strain LLE46), SV40 T antigen was induced in 0.1 to 6% of the cells during the first 96 hr postinfection, morphological changes occurred 3 to 7 weeks later, and eventually all the cells contained SV40 T antigen, but no adeno 7 T antigen. Results were similar when primary and secondary monolayer cultures of hamster embryo (HE) cells were infected with the adeno 7-SV40 hybrid, and when primary HE cells were infected with SV40. However, infection of BHK21, Nil-2, and secondary HE cells with the same multiplicity of SV40 did not induce SV40 T antigen or morphological transformation. This suggests that the target cells required for infection with SV40 virions, but not those required for infection with the hybrid, are lost or altered in secondary HE cultures and in the two cell lines. In most of the virus host cell systems in which SV40 T antigen and transformation were induced, there was a decrease in the number of T antigen-positive cells after the initial infection. This was followed by a lag period of up to 2 months before the onset of a progressive increase in the number of positive cells. The beginning of the rise in T antigen production coincided with the first morphological changes. PMID- 4316244 TI - Replication of the reticuloendotheliosis virus (strain T) in chicken embryo cell culture. AB - Investigations were conducted on the in vitro replication of the reticuloendotheliosis (RE) virus (strain T) in specific-pathogen-free chicken embryo fibroblast (CEF) cultures. Active virus production was detected in the tissue culture fluid 24 hr after infection. When injected into chickens, samples taken 42 hr after infection of the cell cultures killed approximately 50% of the birds at a 1:100 dilution. The RE virus titer remained at this level for 5 days before declining. Cell-free virus preparations from tissue cultures rarely resulted in 100% mortality of the assay birds. The level of cell-associated virus was very low. Evidence that the reticuloendotheliosis was not induced by a mycoplasma was indicated by failure to isolate an organism on PPLO Agar (Difco) and failure of kanamycin or amphotericin B to inhibit multiplication of RE virus in vitro. RE virus appeared to be unrelated to members of the avian leukosis and sarcoma complex. It did not induce resistance in CEF cultures to sarcoma viruses of the A or B subgroup of this complex. Similarly, preinfection of cell cultures with leukosis viruses of the A or B subgroup did not inhibit or reduce the replication of RE virus. PMID- 4316245 TI - Growth curve and distribution of Rous sarcoma virus (Bryan) in Japanese quail. AB - On primary infection with the Bryan strain of Rous sarcoma virus (RSV), the growth curve of the virus in the brain of Japanese quail was similar to that observed in chicks and turkey poults. Infectious virus disappeared from the brain after inoculation. After an eclipse period during which no virus was detectable, infectious virus began to appear at 2 days and reached maximal titers in the brain samples at 7 days after inoculation. When Japanese quail were infected intracerebrally with RSV, relatively high titers of virus were recovered from brain tissue but not from liver, lung, kidney, or blood of moribund birds. Only tumors produced in the wing web of quail infected subcutaneously yielded high titers of virus. Other tissues yielded no virus, even though wing web tumors appeared as early as in chicks similarly infected. RSV could be propagated in the wing web of quail for at least 14 passages without any loss of infectivity. On the other hand, serial passage in quail brain resulted in a progressive loss of infectivity until virus was completely lost. PMID- 4316246 TI - Effect of actinomycin D on virus-induced ribonucleic acid polymerase formation in foot-and-mouth disease virus-infected baby hamster kidney cells. AB - Actinomycin D, at a concentration that inhibits cellular ribonucleic acid (RNA) synthesis, inhibited the production of foot-and-mouth disease virus-induced RNA polymerase in baby hamster kidney cells. Inhibition was proportional to exposure time and reached 85% when actinomycin D was added 90 min before infection. Polymerase production was inhibited to the same extent in growth and minimal media, and the kinetics of its appearance were slightly different than in untreated cells. Enzyme preparations from actinomycin-treated cells having one third to one-tenth the activity of untreated samples gave products with RNA profiles similar to those of controls. The 37S viral peak, 20S ribonuclease resistant peak, and 26 to 28S peaks were present in all cases. Actinomycin D did not consistently inhibit virus production in either medium. Insulin did not prevent the actinomycin induced inhibition of polymerase and virus production from occurring. PMID- 4316247 TI - Studies on circular deoxyribonucleic acid. I. Isolation of bovine papilloma virus and characterization of its deoxyribonucleic acid. AB - A simple method is described for the isolation of bovine papilloma virus and its deoxyribonucleic acid (DNA). As found with other representatives of this virus group, this DNA preparation contains two components, I and II, as shown by sedimentation and electron microscopic studies. Component I is a fast sedimenting, twisted, circular DNA molecule and represents usually 70 to 90% of the DNA in the mixture. The direction of the twist in the superstructure is right handed. Component II originates from I by one or more single-strand breaks and is the "relaxed" circular from of the viral DNA. PMID- 4316248 TI - Specific role of each human leukocyte type in viral infections. I. Monocyte as host cell for vesicular stomatitis virus replication in vitro. AB - Each major leukocyte type of the peripheral blood of healthy donors was studied in vitro for its ability to support vesicular stomatitis virus (VSV) replication. Purified cultures of each white blood cell type were prepared by the selective adsorption and elution of cells from silicone-treated glass beads. It was found that monocytes and macrophages (derived from the rapid transformation of monocytes in vitro) were the principal host cells for VSV replication. Interferon added to mixed leukocyte cultures, prior to virus inoculation, reduced virus yields and prevented destruction of macrophages. Cultures of small lymphocytes, containing no detectable monocytes or macrophages, produced amounts of virus equivalent to 1% of that produced in leukocyte cultures which contained 7% monocytes. Small lymphocytes did not undergo demonstrable cytopathic alterations in virus-infected cultures. VSV neither replicated nor produced cytopathic effects in polymorphonuclear leukocytes. PMID- 4316249 TI - Transient inhibition of avian myeloblastosis virus reproduction by amethopterin and fluorodeoxyuridine. AB - Avian myeloblastosis virus cannot initiate its reproduction in the presence of amethopterin or fluorodeoxyuridine. This inhibition is reversed by thymidine. Addition of either inhibitor after virus production has started does not inhibit further virus synthesis. In presence of either inhibitor, deoxyribonucleic acid synthesis is inhibited by over 90%, but ribonucleic acid synthesis is not affected. Cells resume their normal growth rate 24 hr after removal of either inhibitor. PMID- 4316250 TI - Interferon production in mice by cell wall mutants of Salmonella typhimurium. AB - The interferon response elicited by Salmonella typhimurium mutants in mice is not dependent on the presence of a complete cell wall lipopolysaccharide. In fact, a mutant (G30/C21) which has lost all the polysaccharide side chains and sugars of the O antigen and contains only 2-keto-3-deoxyoctonate and lipid is indistinguishable in its interferon-stimulating ability from the wild type which possesses a complete O antigen with polysaccharide side chains. PMID- 4316252 TI - [Influence of the laboratory adaptation of sleep on the skin potential responses]. PMID- 4316253 TI - [Glandular neoplasms of the ear]. PMID- 4316251 TI - In vitro and in vivo observations on a murine C-type virus. AB - From 40 discrete mouse tissue culture cell lines examined by electron microscopy or complement fixation, or both, for the presence of detectable virus, one (NCTC 4705), initiated and maintained on chemically defined medium, was chosen for a more extensive study. Virus-like particles (100 to 110 mmu), morphologically similar to previously reported immature and mature C-type leukemia virus particles, were found budding from the plasma membrane and free in the intracellular spaces of cells in tissue culture and in fibrosarcomas resulting from intramuscular implants of these tissue cultures. Complement-fixation tests for group reactive murine leukemia antigens were positive, with titers consistently higher to a broadly reactive anti-serum than to anti-Friend, anti Moloney, or anti-Rauscher sera. The 4705 virus was neutralized by Gross antiserum, but not by the F-M-R antisera. When injected into DD, BALB/c, or C3H/He newborn mice, the virus thus far has manifested no leukemogenicity, though virus from tumor extracts and tissue culture medium has been shown to be capable of infecting C3H and Swiss mouse embryo tissue cultures and successfully replicating in them. The role of the virus in accelerating or inducing neoplastic transformation in NCTC 4705 is still not known. When it was introduced into NCTC [ill], a non-neoplastic cell line in other respects similar to NCTC 4705, 4823 manifested no signs of neoplastic transformation after harboring the virus more than 300 days in vitro. PMID- 4316254 TI - The value of electromyographic changes in the early diagnosis of carbon disulphide peripheral neuropathy. PMID- 4316255 TI - [On the possibility of the appearance of silicosis in workers in the production of ferrosilicon]. PMID- 4316256 TI - [On some cases of acute respiratory insufficiency caused by obstruction of the respiratory passages]. PMID- 4316257 TI - Peripheral neuropathy in uremia. Pathological studies on peripheral nerves from 6 patients. PMID- 4316258 TI - Effect of imidazole and its derivatives on norepinephrine-, ACTH-, theophylline- and dibutyryl cyclic AMP-induced lipolysis in isolated rat fat cells. PMID- 4316259 TI - [Carbohydrate metabolism in patients with hypophyseal and extrahypophyseal tumors]. PMID- 4316260 TI - Antagonistic effect of foreign compounds on microsomal enzymes of the liver of the rat. PMID- 4316261 TI - Maculotoxin, a potent toxin secreted by Octopus maculosus Hoyle. PMID- 4316262 TI - Results of 22 cases of breast sarcoma over five years after surgery. PMID- 4316264 TI - [Possibilities for quantitative determination of nitrifying bacteria]. PMID- 4316265 TI - [Mycoplasma infection and histopathology of experimental enzootic pneumonia in pigs]. PMID- 4316263 TI - Strongly acid intestinal content and lowered protein, carotene and vitamin A blood levels in Eimeria acervulina infected chickens. PMID- 4316266 TI - [Respiratory tract diseases in calf and cattle herds]. PMID- 4316267 TI - [Stability of aqueous solutions of viomycin sulfate]. PMID- 4316268 TI - Current concepts of the regulation of urinary sodium excretion--a review. PMID- 4316269 TI - [Utilization of plastic ribbons for the collection of eggs and larval and nymphal stages of simulids (Diptera Paranematocera) and for their biological study]. PMID- 4316270 TI - Metabolism of tryptophan by Pseudomonas aureofaciens. 3. Production of substituted pyrrolnitrins from tryptophan analogues. AB - Exogenous tryptophan is metabolized by Pseudomonas aureofaciens to yield pyrrolnitrin [3-chloro-4-(2'-nitro-3'-chlorophenyl)-pyrrole], an antifungal agent. The ability of this culture to metabolize tryptophan analogues in a similar manner was investigated by addition of the appropriate compound to the fermentation. Tryptophan precursors and metabolites or nonphenyl-substituted tryptophans had little effect on pyrrolnitrin biosynthesis, but simple derivatives of indole inhibited the production of pyrrolnitrin. Tryptophans substituted at the 4 position decreased pyrrolnitrin production and were converted into the corresponding substituted indoles. Tryptophans substituted at the 5, 6, and 7 position with fluorine or at the 5 and 7 position with methyl yielded new pyrrolnitrin derivatives. Substitution of larger groups (such as chloro, bromo, trifluoromethyl, and methoxy) at these positions led to the formation of the intermediate, amino pyrrolnitrin [3-chloro-4-(2'-amino-3' chlorophenyl)-pyrrole], with the appropriate new substituent. The trifluoromethyl group at the 6 position of tryptophan prevented chlorination at the 3 position of pyrrolnitrin. PMID- 4316271 TI - Bacteriological examination of commercial precooked Eastern-type turkey rolls. AB - Studies were conducted to ascertain the bacteriological condition of commercially cooked Eastern-type (foil-wrapped-oven roasted) turkey rolls during processing and storage. After 2 weeks at 5 C, numbers of aerobes on the surface of rolls, in slices, and in whole rolls reached levels of from 1 to 10 million per cm(2) or per g. In stored whole rolls, coliform and enterococcus counts ranged, respectively, from about 10,000 to more than 1 million per g and from < 100 to more than 1 million per g. Postcooking processing operations in two plants did not significantly affect the total count of turkey rolls. Eight of 28 rolls obtained after handling and packaging contained coagulase-positive staphylococci. PMID- 4316272 TI - Viremia and virus measurements of rabbit pox in CV-1 cells. AB - Rabbit pox virus (RPV) produced cytopathic effect (CPE) in five types of cells grown in tissue cultures. The CPE on CV-1 cells was characterized by cell fusion and lysis. The CV-1 line is a useful and sensitive cell culture for measuring concentrations of RPV in blood and tissues of infected rabbits. Viremia was detected between the 2nd and 4th days after parenteral infection. By the 6th and 7th days, the concentration of RPV in various tissues ranged from 10(5-3) to 10(8 5) TCID(50)/g. Cross-reactivity was demonstrated by the fluorescent-antibody technique between rabbit pox, vaccinia, and monkey pox viruses. PMID- 4316274 TI - Enhancement by poly-D-lysine of poly I: C-induced interferon production in mice. AB - Poly-d-lysine of high molecular weight enhances interferon induction in mice by the double-stranded complex of polyinosinic and polycytidylic acids and is superior to diethylaminoethyl-dextran in this respect. PMID- 4316275 TI - Rapidly progressing adenoid cystic carcinoma. PMID- 4316273 TI - Ultraviolet devitalization of eight selected enteric viruses in estuarine water. AB - The effect of ultraviolet (UV) radiation on the devitalization of eight selected enteric viruses suspended in estuarine water was determined. The surviving fractions of each virus were calculated and then plotted against the UV exposure time for purposes of comparison. Analytical assessment of the survival data for each virus consisted of least squares regression analysis for determination of intercepts and slope functions. All data were examined for statistical significance. When the slope function of each virus was compared against the slope function of poliovirus type 1, the analytical findings indicated that poliovirus types 2 and 3, echovirus types 1 and 11, and coxsackievirus A-9 exhibited similar devitalization characteristics in that no statistically significant difference was found (P > 0.05). Conversely, the devitalization characteristics of coxsackievirus B-1 and reovirus type 1 were dissimilar from those of poliovirus type 1 in that a statistically significant difference was found between the slope functions (P < 0.05). This observed difference in devitalization of coxsackievirus B-1 and reovirus type 1 was attributed primarily to the frequency distribution of single and aggregate virions, the geometric configuration, the size of the aggregates, and the severity of aggregation. The devitalization curve of coxsackievirus B-1 was characteristic of a retardant die away curve. The devitalization curve of reovirus type 1 was characteristic of a multihittype curve. The calculated devitalization half-life values for poliovirus types 1, 2, and 3; echovirus types 1 and 11; coxsackievirus types A-9 and B-1; and reovirus type 1 were 2.8, 3.1, 2.7, 2.8, 3.2, 3.1, 4.0, 4.0 sec, respectively. These basic data should facilitate an operative extrapolation of the findings to the applied situation. It was concluded that UV can be highly effective and provide a reliable safety factor in treating estuarine water. PMID- 4316276 TI - [Effect of some factors on the metabolism of calcium and strontium]. PMID- 4316277 TI - [Current clinical aspects of viral encephalitis]. PMID- 4316278 TI - Schwann cell lysosomes in hypertrophic neuropathy and in normal human nerves. PMID- 4316279 TI - Fatal hepatitis in siblings: isolation of coxsackievirus B5 and herpes simplex virus. PMID- 4316280 TI - [A rare case of mixed tumor in the skin of the nose]. PMID- 4316281 TI - The uptake of 45Ca by individual phospholipids isolated from guinea pig heart mitochondria and the effect of various drugs. PMID- 4316282 TI - Uptake and retention of 3H-noradrenaline in adrenergic nerve terminals after reserpine and axotomy. PMID- 4316283 TI - Effects of angiotensin, oxytocin and vasopressin on placental circulation. An angiographic study in rabbits. PMID- 4316284 TI - Symposium on Immunity to Selected Canine Infectious Diseases. Report of the panel. PMID- 4316286 TI - A comparison of the pathogenesis and antigenicity of infectious canine hepatitis virus and the A26-61 virus strain (Toronto). PMID- 4316285 TI - Comments on viruses recovered from dogs. PMID- 4316287 TI - Comments on infectious canine hepatitis and Toronto A26-61 virus. PMID- 4316288 TI - Chronic hepatitis in the dog: the role of immune factors. PMID- 4316289 TI - Clinical observations of canine herpesvirus. PMID- 4316290 TI - Herpesvirus canis: aspects of pathogenesis and immune response. PMID- 4316291 TI - Comments on canine herpesvirus: pathogenesis and immune response. PMID- 4316292 TI - The epizootiology of canine parainfluenza. PMID- 4316293 TI - Comments on epizootiology of parainfluenza SV-5 in dogs. PMID- 4316294 TI - SV-5-like parainfluenza virus in dogs. PMID- 4316295 TI - Summary of the Symposium on Immunity to Selected Canine Infectious Diseases. PMID- 4316296 TI - Enzyme localizations with Gomori type lead phosphate procedures: real or artifact. PMID- 4316297 TI - The intracellular release of lysosomal contents in macrophages that have ingested silica. PMID- 4316298 TI - The effect of denervation on incorporation of 32P and (3H)glycerol by the muscle membrane. PMID- 4316299 TI - Animal viruses: cells modified. PMID- 4316300 TI - RNA-dependent DNA polymerase in virions of RNA tumour viruses. PMID- 4316302 TI - Recognition sites around the catalytic centre of DNA-dependent RNA polymerase. PMID- 4316301 TI - RNA-dependent DNA polymerase in virions of Rous sarcoma virus. PMID- 4316303 TI - New mechanism for the control of cellular reactions: the biochemical flip-flop. PMID- 4316305 TI - Evidence for peripheral neurotoxic effect of trichloroethylene. PMID- 4316304 TI - Electrodiagnostic study of trigeminal nerve. Orbicularis oculi reflex and masseter reflex in trigeminal neuralgia, paratrigeminal syndrome, and other lesions of the trigeminal nerve. PMID- 4316306 TI - Is there a biochemical lesion in the disease of alcoholism? PMID- 4316307 TI - [Experience with the patient-club in the system of a flexible rehabilitation program in psychiatry]. PMID- 4316309 TI - [Distribution of excitation transmission in vegetative ganglion under the effect of ionizing radiation and its role in the internal organ regulation]. PMID- 4316308 TI - Delirium acutum, a potentially fatal condition in the psychiatric hospital. PMID- 4316310 TI - [Cylindroma of the oral cavity]. PMID- 4316311 TI - Replication of defective and competent forms of murine sarcoma virus in mouse cell cultures. PMID- 4316312 TI - The interaction of polyoma virus with mouse-hamster somatic hybrid cells. PMID- 4316313 TI - Double-stranded DNA from cauliflower mosaic virus. PMID- 4316314 TI - Density gradient centrifugation of a herpesvirus (IBRV) in colloidal silica. PMID- 4316315 TI - Reaction of the human anti-gelatine factor with gelatine from different species and with collagen peptides. PMID- 4316316 TI - [Electromyographic diagnosis of mechanical ulnar injuries at the elbow joint]. PMID- 4316317 TI - [Origin of sarcoidosis granuloma cells]. PMID- 4316318 TI - [Activity of certain blood enzymes in healthy children and children with chronic nutritional disorders]. PMID- 4316319 TI - [Studies on the fibrous composite alloys for medical and dental use]. PMID- 4316320 TI - [Clinical study of relapses and metastases of salivary gland cylindromas]. PMID- 4316321 TI - [Surgical treatment of cerebral hemispheric tumours of the macroglial series]. PMID- 4316322 TI - [Various methodologic features of culturing macroglial tumours]. PMID- 4316323 TI - Effect of gamma-irradiation on spores of some species of the Clostridium genus. PMID- 4316324 TI - [On the so-called thalamic dementia. Apropos of a case of circumscribed neoplasm of the medial nuclei of the thalamus]. PMID- 4316326 TI - Soft tissue tumors of the penis. A clinicopathologic study of 46 cases. PMID- 4316325 TI - Carbenicillin treatment of Pseudomonas pulmonary infection. Use in children with cystic fibrosis. PMID- 4316327 TI - Carcinoma of the trachea. Clinicopathologic study of 41 cases. PMID- 4316328 TI - Morphology and metabolism of intact muscle cells isolated from adult rat heart. PMID- 4316329 TI - [A test for assessing the responsiveness of plasma renin activity]. PMID- 4316330 TI - [Biologically effective vitamin D3 metabolites]. PMID- 4316331 TI - Regulation of nuclear DNA synthesis in rat liver. PMID- 4316333 TI - [Hormonal control of water turnover and balance in the intact and hypophysectomized fresh water teleost Carassius auratus]. PMID- 4316332 TI - [On the use of epsilon-aminocaproic acid for prevention of complications caused by iodized contrast media]. PMID- 4316334 TI - [A rare tumor of the prostate. A case of muco-secreting cancer]. PMID- 4316335 TI - Cholera-like syndrome and pancreatic islet cell tumors. PMID- 4316336 TI - Extreme antidiuresis in response to chlorpropamide administered intravenously during angiotensin infusion in diabetes insipidus. PMID- 4316337 TI - [The use of P32 in the diagnosis of Paget's breast cancer]. PMID- 4316338 TI - [The influence of vibration on the functioning of the cortex of the adrenal gland]. PMID- 4316339 TI - [Tumors arising from the parasympathetic aortic bodies (Chemodectoma Glomeris Aortici)]. PMID- 4316340 TI - The effect of external potassium ion concentration on autonomic neuro-muscular transmission. PMID- 4316342 TI - The pharmacological basis for the treatment of myasthenia gravis. PMID- 4316341 TI - Role of angiotensin in the salt-hypertension of rats. PMID- 4316343 TI - Angiography of hepatic neoplasms. PMID- 4316344 TI - [Clinical roentgenologic experiences with a new contrast medium for investigation of the urinary tract]. PMID- 4316345 TI - DNA's from human hepatoma and gastric cancer mitochondria. PMID- 4316346 TI - Vaccination with complete adjuvant-added inactivated virus vaccine of Japanese encephalitis to swine, rabbits and chicks for preventing viremia (epidemiological study on Japanese encephalitis 25). PMID- 4316347 TI - Posttransfusion mononucleosis with heterophil antibodies. Simultaneous infection with cytomegalovirus and EB virus. PMID- 4316349 TI - Guide for respirable mass sampling. PMID- 4316348 TI - The pulmonary response to fibrous dusts of diverse compositions. PMID- 4316350 TI - Toxoplasmosis: recent developments. PMID- 4316351 TI - [Brown fat]. PMID- 4316352 TI - Spin-labeling studies of aminoacyl transfer ribonucleic acid. PMID- 4316353 TI - Studies on the purification of Entamoeba histolytica antigens by gel filtration. I. Some physicochemical properties of the isolated fractions. PMID- 4316354 TI - Studies on the purification of Entamoeba histolytica antigens by gel filtration. II. The antigenic properties of the isolated fractions. PMID- 4316355 TI - Release of a prostaglandin-like substance into renal venous blood in response to angiotensin II. PMID- 4316356 TI - Catecholamines-cyclic amp-angiotensin receptors. Plasma catecholamine concentrations in patients with hypertension. PMID- 4316357 TI - The relationship between plasma renin and aldosterone in normal man. PMID- 4316358 TI - The collagenolytic enzyme of the regenerating limb of the Newt triturus viridescens. PMID- 4316359 TI - Testes and Seminal vesicles of normal rat and mouse: a comparative biochemical study. PMID- 4316360 TI - Electron-spin-resonance spectroscopy of radiation-induced free radicals in irradiated single crystals of thymine monohydrate. PMID- 4316361 TI - Characterization of the lipids of Butyrivibrio fibrisolvens. AB - Butyrivibrio fibrisolvens strain D-1 was grown on a lipid-free chemically defined medium. The lipids were extracted with chloroform-methanol and separated into nonpolar and polar fractions by silicic acid column chromatography. Further separations were made by preparative thin-layer chromatography. The lipid fractions were identified by specific staining reactions and R(F) values, by phosphorus and nitrogen determinations, by chromatography of hydrolysis products, and by the use of infrared spectroscopy. The major nonpolar lipid was free fatty acid. Four major polar lipids were identified: phosphatidylethanolamine, phosphatidyl glycerol, lipoaminoacid, and glycolipid. The lipoaminoacid contained alanine, leucine, and isoleucine. The glycolipid contained galactose. The major fatty acids identified were C16:0 and C18:1. The significance of the presence of lipoaminoacid is discussed. PMID- 4316362 TI - Cardiolipin-specific phospholipase D activity in Haemophilus parainfluenzae. AB - A highly active phospholipase D that is specific for cardiolipin was detected in the gram-negative bacterium Haemophilus parainfluenzae. Previously reported phospholipase D preparations have come exclusively from higher plants. The bacterial enzyme hydrolyzed cardiolipin to phosphatidyl glycerol and phosphatidic acid. During the incubation, phosphatidic acid disappeared. Phosphatidyl ethanolamine, methylated phosphatidyl ethanolamines, phosphatidyl choline, and phosphatidyl glycerol were not hydrolyzed when cardiolipin was rapidly hydrolyzed. PMID- 4316363 TI - Electron transport in halophilic bacteria: involvement of a menaquinone in the reduced nicotinamide adenine dinucleotide oxidative pathway. AB - The reduced nicotinamide adenine dinucleotide oxidative pathway of a halophilic bacterium was found to contain a light-sensitive (360 nm) compound, menaquinone 8, which serves as a cofactor in the nicotinamide adenine dinucleotide(+)-linked pathway. PMID- 4316364 TI - Cholesterol inhibition of isopentenyl pyrophosphate delta3, delta2-isomerase in Mycoplasma laidlawii. AB - Cholesterol inhibits isopentenyl Delta(3),Delta(2)-isomerase of Mycoplasma laidlawii in an apparently competitive fashion. The conversion of mevalonic acid to isopentenyl pyrophosphate is slightly stimulated. Organisms grown in the presence of mevalonic-2-(14)C acid contain small amounts of radio-label in nucleic acid and protein fractions. Most of the label is found in the lipids and is reduced dramatically in organisms grown with cholesterol. No significant accumulation of phosphorylated intermediates of polyterpene biosynthesis was observed in cells or culture supernatant fluid. All of the radioactivity appearing in the nucleic acid fraction occurs in the minor nucleoside, isopentenyl adenosine, of the transfer ribonucleic acid. The necessity for synthesis by the organisms of this minor nucleoside from mevalonic acid may explain the site of enzyme inhibition by cholesterol of polyterpene biosynthesis. PMID- 4316365 TI - Immunological studies on guinea pig serum and liver L-asparaginases. Purification of L-asparaginases by antibody precipitation. PMID- 4316366 TI - Aldehyde dehydrogenase and ethanol preference in mice. PMID- 4316368 TI - Citrate synthase. A regulatory enzyme from Rhodopseudomonas capsulata. PMID- 4316367 TI - Further studies of stimulation of anterior pituitary cyclic adenosine 3',5' monophosphate formation by hypothalamic extract and prostaglandins. PMID- 4316369 TI - Enzymatic characterization of the N-acetylation of 3-phosphoglyceraldehyde dehydrogenase by acetyl phosphate. PMID- 4316370 TI - Purification and properties of a pink copper protein from human erythrocytes. PMID- 4316371 TI - Studies of the binding of phosphoribosyl pyrophosphate to adenine phosphoribosyltransferase. PMID- 4316372 TI - Nephrotic syndrome caused by a seed disinfectant. PMID- 4316373 TI - [Alcoholism-an urgent task for social psychiatry]. PMID- 4316374 TI - An attempt of hybridization of Rous sarcoma virus and parotitis virus. PMID- 4316375 TI - Epithelial hepatoblastoma associated with congenital hemihypertrophy and cystathioninuria: presentation of a case. PMID- 4316376 TI - The development of glyoxysomes in peanut cotyledons and maize scutella. AB - The development of glyoxysomes during germination has been studied in isolated peanut (Arachis hypogaea L.) cotyledons and in maize (Zea mays L.) scutella. In peanut cotyledons isocitratase, malate synthetase, and protein associated with the glyoxysomal fraction increase simultaneously from the 3rd to the 8th day of incubation. In scutella of germinating maize seeds the specific activities of isocitratase, malate synthetase, and catalase associated with the glyoxysomes rise until the 4th day of germination and then decline while the total amount of protein present in the fraction stays constant during the first 5 days. If the peanut cotyledons are cultured in 2% glucose, the development of isocitratase and malate synthetase is severely inhibited, but the level of the glyoxysomal protein is not measurably affected. PMID- 4316377 TI - Characterization of rapidly labeled ribonucleic acid from dwarf peas. AB - The ribonucleic acid synthesized by excised shoots of dwarf pea (Pisum sativum L. cv. Progress No. 9) during short labeling periods has been characterized. Thirty percent of the total (32)P(i) incorporated in 1 hour is found in the ribosomal fraction. This labeled RNA was polydisperse (6-18 Svedberg units) and after chromatography on a methylated albumin-kieselguhr column about 80% of the radioactivity appeared in two peaks. One of these appeared on the shoulder of heavy ribosomal RNA ("mRNA") while the other was tenaciously bound to the column (TB-RNA). In the presence of high NaCl concentration, about half of the polydisperse RNA interacted with ribosomal RNA and eluted as "mRNA" while the remainder eluted as TB-RNA. This interaction in the presence of salt seems to result in the alteration of secondary structure because the "mRNA" fraction had a high sedimentation coefficient (45-50 Svedberg units). The polydisperse RNA approaches DNA in low cytidylate and guanylate content. After short periods of labeling TB-RNA showed higher adenylate content than "mRNA." The radioactivity from the "mRNA" peak can be chased, and these counts may represent a class of shortlived messenger RNA molecules with an average half-life of 10 to 15 minutes. The other component, TB-RNA, could not be chased and accumulated radioactivity during the chase period. PMID- 4316378 TI - Hand tumors in children. PMID- 4316379 TI - Infectious SV40 and SV40 DNA: rapid fluorescent focus assay. PMID- 4316380 TI - The influence of norethynodrel on the hypophysis. PMID- 4316381 TI - Study of the potential carcinogenicity of DDT in the Syrian golden hamster. PMID- 4316382 TI - Contrasting degradation rates of synthetic angiotensin amide and natural angiotensin in human plasma. PMID- 4316384 TI - Riboflavin protection against azo dye hepatoma induction in the rat. PMID- 4316383 TI - SV40 transformation of human amnion cells under different culture conditions. PMID- 4316385 TI - Effect of desmethylimipramino on hormone-, theophylline-, and dibutyryl cyclic AMP-induced lipolysis in isolated rat fat cells. PMID- 4316386 TI - Mycoplasma effects on SV40 transformation of human amnion cells. PMID- 4316387 TI - Demonstration of the chemotactic properties of collagen. PMID- 4316388 TI - Presence of 2 different viral agents in brain cells of patients with subacute sclerosing panencephalitis. PMID- 4316389 TI - Converting enzyme in rat serum. PMID- 4316390 TI - New tuberculins. PMID- 4316391 TI - Age-related cellular resistance of the chicken embryo to viral infections. 3. Escherichia coli resistance-inducing protein. PMID- 4316392 TI - Effect of foot-and-mouth disease virus on protein synthesis and ribonucleic acid polymerase activity at various temperatures. PMID- 4316393 TI - The quantification of renin liberated in vitro from rat kidney slices. PMID- 4316394 TI - [Studies of the effect of prolonged steroid administration on serum protein pattern in cases of pemphigus and pemphigoid]. PMID- 4316395 TI - [X-ray findings of so-called alveolar cell carcinoma of the lung]. PMID- 4316396 TI - [Deficiencies of a single anterior pituitary hormone]. PMID- 4316397 TI - Pathophysiology of disseminated intravascular coagulation. PMID- 4316398 TI - Eosinophil mobilization during disseminated intravascular coagulation. PMID- 4316399 TI - [The behavior of adenovirus type 12 in the bodies of monkeys]. PMID- 4316400 TI - [Induction of the "tumor" (T) antigen of SV40 virus in various tissue cultures]. PMID- 4316402 TI - [Cytomegaly in the newborn-etiopathogenesis, clinical aspects and therapy]. PMID- 4316401 TI - [Reproduction of experimental hepatitis in puppies]. PMID- 4316403 TI - [A case of congenital generalized cytomegaly, simulating toxoplasmosis]. PMID- 4316404 TI - Concurrence of endometrial stromal malignancy with ovarian theca cell tumor. PMID- 4316405 TI - The effect of methotrexate and dactinomycin on transplantable malignant and benign trophoblastic growths. PMID- 4316406 TI - Effects of perfusion of chorionic and human postmenopausal gonadotropins on the secretion of cortisol and 17-ketosteroids in the dog. PMID- 4316407 TI - Benign ovarian stromal tumors associated with free peritoneal fluid. PMID- 4316408 TI - [The complex action of angiotensin]. PMID- 4316409 TI - Corneal infiltrates in epidemic keratoconjunctivitis. Response to double-blind corticosteroid therapy. PMID- 4316410 TI - Experimental herpes simplex keratitis. Early alterations of corneal epithelium and stroma. PMID- 4316411 TI - [Short-latent interstitiospinal and rubrospinal synaptic influences on alpha motor neurons]. PMID- 4316412 TI - On the activity of glucose-6-phosphate phosphohydrolase in the red blood cells. PMID- 4316413 TI - [The value of indirect lymphography in breast carcinoma]. PMID- 4316414 TI - [Isolated visceral neurofibromatosis]. PMID- 4316415 TI - Some biophysical properties of isolated rhinoviruses. PMID- 4316416 TI - [Enzymes and liver pathology]. PMID- 4316417 TI - [Primary cancer of the liver. Pathological anatomy--primary cancer of the liver and hepatic cirrhosis]. PMID- 4316418 TI - [Primary carcinoma of the liver. Clinical aspects--laparoscopy--functional diagnosis and differential diagnosis of hepatic cirrhosis]. PMID- 4316419 TI - [Model experiments on signal propagation in nerve nets]. PMID- 4316420 TI - The residual adrenocorticotropic activity of the hypophysis after its neural disconnection. PMID- 4316421 TI - Vaccination with live type 4 adenovirus: evaluation of antibody response and protective efficacy. PMID- 4316422 TI - Herpes simplex keratitis. Potentiation with normal horse serum and antilymphocyte serum. PMID- 4316423 TI - Collagenolytic activity in the cornea of the metamorphosing tadpole. PMID- 4316424 TI - The reproduction of and genetic resistance to Marek's disease in fowls. PMID- 4316425 TI - Efficiency of hybrid cell formation from heterokaryons fused by HVI. PMID- 4316426 TI - Autoradiographic and cytochemical studies on nuclear and cytoplasmic inclusions of duck embryo fibroblasts infected with herpes type virus isolated from chickens with Marek's disease. PMID- 4316427 TI - Platelet aggregation. 3. An epinephrine induced decrease in cyclic AMP synthesis. PMID- 4316428 TI - Alpha-ketoglutarate: glyoxylate carboligase activity in Escherichia coli. PMID- 4316429 TI - Association of cardiolipin and cytochrome oxidase. PMID- 4316430 TI - Loss and maintenance of energy-linked functions in aged mitochondria. PMID- 4316431 TI - Initiation of DNA synthesis in rat thymus: correlation of calcium-dependent initiation in thymocytes and in isolated thymus nuclei. PMID- 4316432 TI - Estimation of the molecular weight of ribulose diphosphate carboxylase sub-units. PMID- 4316433 TI - Two cases of "pancreatic cholera" with features of peptide-secreting adenomatosis of the pancreas. AB - The clinical data are presented of two women with profound metabolic upset from exceptional water and electrolyte losses in diarrhoea. One had an islet-cell adenoma of the pancreas and the other abnormal islets. Gastric and pancreatic function were abnormal in both, consistent with the subsequent demonstration of a pancreatic and choleretic secretagogue in the tumour tissue and pancreatic and gastric secretagogues in circulating blood (Cleator, Thomson, Sircus, and Coombes, 1970). PMID- 4316434 TI - Liver biopsy in the diagnosis of cirrhosis. PMID- 4316435 TI - [Cyclophosphamide as adjuvant treatment of the advanced ovarian carcinoma]. PMID- 4316436 TI - [Histoenzymatic functions of the evolution and luteolysis of the rabbit corpus luteum]. PMID- 4316438 TI - A peculiar form of malignant hepatoma in a White Leghorn hen. PMID- 4316437 TI - Some cytochemical correlations between oxidase activity (cytochrome and Peroxidase and chemical structure of bis(phenylenediamines). PMID- 4316439 TI - Hepatocellular carcinoma in a pig. PMID- 4316440 TI - A seroepidemiologic study of infectious mononucleosis. The development of EB virus antibody in a military population. PMID- 4316442 TI - [Experimental studies on the prophylactic and therapeutic effectiveness of biomycin in gas anaerobic infection]. PMID- 4316441 TI - "Non-pheochromocytoma". PMID- 4316443 TI - [Cytomegalic inclusion disease (on some personal cases)]. PMID- 4316444 TI - The weakest go to the wall. PMID- 4316445 TI - [Some familial congenital deformities of the weight-bearing locomotor apparatus]. PMID- 4316446 TI - [The effect of ionizing radiation on presynaptic terminals]. PMID- 4316447 TI - [The effect of ionizing radiation on the functional state of the neuromuscular synapses of frogs]. PMID- 4316448 TI - [Physiological relations between secretion of aldosterone and the renin angiotensin system. Bibliographic review]. PMID- 4316449 TI - [Ultrastructure of synapses and the problem of synaptic transmission]. PMID- 4316451 TI - [Virus etiology of erythema multiforme exudativum]. PMID- 4316450 TI - [Current concepts of the mechanism of vasoconstrictor and vasodilator neural activity]. PMID- 4316452 TI - [Chemodectoma of the nasal cavity]. PMID- 4316453 TI - Fatal disseminated cytomegalic inclusion disease in an adult presenting with a lesion of the gastrointestinal tract. PMID- 4316454 TI - Simultaneous determination of tissue copper and calcium. PMID- 4316455 TI - Inhibitory effect of ferrous ions on Warren assay of N-acetylneuraminic acid. PMID- 4316456 TI - Attachment to split-beam spectrophotometer for absorbance recording in round tubes of small diameter. PMID- 4316457 TI - Analysis of adenosine 3',5'-monophosphate with luciferase luminescence. PMID- 4316458 TI - [Recurrent chemodectoma of the orbit]. PMID- 4316459 TI - Synthesis and properties of nucleotides containing 4-thio-D-ribofuranose. PMID- 4316460 TI - [EPR study of the free radicals formed during the reaction of ninhydrin with amino acids, peptides and proteins]. PMID- 4316461 TI - [Photooxidation of tyrosine sensitized by chlorophyll derivatives]. PMID- 4316462 TI - [Magnetic susceptibility and electron spectra of albomycin]. PMID- 4316463 TI - [Quantitative evaluation of ionic currents through the membrane of the soma of giant neurons of the pulmonary mollusc Planorbis corneus during action potential generation]. PMID- 4316464 TI - [Free radicals in phosphorylated and nonphosphorylated mitochondria]. PMID- 4316465 TI - [Transplantable rat sarcoma, strain TW-2357]. PMID- 4316466 TI - Interrelationships between copper deficiency and dietary ascorbic acid in the rabbit. PMID- 4316467 TI - On the ultrastructural cytochemistry of nuclear pores in Novikoff hepatoma cells. PMID- 4316468 TI - [Programmed molecules]. PMID- 4316469 TI - The mechanism of tetrodotoxin on the in situ acetylcholinesterase in the vagal heart system of Rana pipiens. PMID- 4316470 TI - Functional sites of transfer RNA for the binding to messenger RNA-ribosome complex. PMID- 4316471 TI - Reactions of 3,5,3',5'-tetraiodothyroacetic acid with inorganic pyrophosphate and related compounds. PMID- 4316472 TI - Bacteriological and viral aetiology of bronchiolitis and bronchopneumonia in Lagos children. PMID- 4316473 TI - [Neuro-muscular para-neoplastic syndromes in primary bronchial cancer]. PMID- 4316474 TI - [Bronchiolar carcinoma]. PMID- 4316475 TI - [The neuro-reflex mechanism of action of corticoid therapy, ACTH-cortisone, in vaginal administration]. PMID- 4316476 TI - [Secondary hyperaldosteronism]. PMID- 4316477 TI - [Clinical tests of a new long-acting form of synthetic ACTH: Cortrosyn Depot]. PMID- 4316478 TI - Characterization of radiation-induced free radial reactions in aqueous systems. II. Physical sciences. 2. Radiological sciences. BNWL-1307. PMID- 4316479 TI - [The clinical picture and genesis of neurotrophic disorders in diseases of the peripheral nervous and vascular systems]. PMID- 4316481 TI - Spontaneous herpes-like viral infection in a chinchilla (Chinchilla laniger). PMID- 4316480 TI - Bluetongue virus in North American elk. PMID- 4316482 TI - [Cell multiplication and the course of redox potential during fermentation of Saccharomyces cerevisiae]. PMID- 4316483 TI - Epidemic keratoconjunctivitis. PMID- 4316484 TI - The effect of trigeminal resection on reflex bronchoconstriction after nasal and nasopharyngeal irritation in man. PMID- 4316485 TI - Central salivary gland tumors of jaws. PMID- 4316486 TI - Primary carcinoma of the liver in Hiroshima and Nagasaki, Japan. PMID- 4316487 TI - Gonadal hormones as regulators of pineal adenyl cyclase activity. PMID- 4316488 TI - In vivo induced oxidation by thyrotropin of reduced pyridine nucleotides on rabbit and rat thyroid. PMID- 4316489 TI - Effects of epinephrine on iodine and intermediary metabolism in isolated thyroid cells. PMID- 4316490 TI - Steroidogenic and morphologic effects of ACTH on human fetal adrenal cells grown in tissue culture. PMID- 4316491 TI - Intrathyroidal thyrocalcitonin levels in neonatal and adult rats. PMID- 4316492 TI - [Viral hepatitis]. PMID- 4316493 TI - REM sleep and the autistic child. PMID- 4316494 TI - Personality and dreams. PMID- 4316495 TI - Individual differences in dreaming. PMID- 4316496 TI - Rhythmic functions during sleep. PMID- 4316497 TI - Stage REM variability and dreaming. PMID- 4316498 TI - Temporal patterns of dreams. PMID- 4316499 TI - REM and NREM nightmares. PMID- 4316500 TI - A note on the nightmare. PMID- 4316501 TI - Sleep research and basic neurophysiology. PMID- 4316502 TI - The dream in psychoanalytic practice. PMID- 4316503 TI - Comments on the 90-minute sleep-dream cycle. PMID- 4316504 TI - Psychoanalytic dream theory reexamined. PMID- 4316505 TI - Is the domain of the psychological still floating? PMID- 4316506 TI - The relationship between REM sleep and learning: animal studies. PMID- 4316507 TI - Dreaming and memory. PMID- 4316508 TI - Age-related changes in sleep characteristics. PMID- 4316509 TI - On the functions of the sleep phases. PMID- 4316511 TI - The programing (P) hypothesis for REM sleep. PMID- 4316510 TI - REM sleep and mechanisms of oculomotor control. PMID- 4316512 TI - Length and distribution of sleep and the intrasleep process. PMID- 4316513 TI - The D-state and norepinephrine-dependent systems. PMID- 4316514 TI - The adaptive function of dreaming. PMID- 4316515 TI - Possible functions of dreaming. PMID- 4316516 TI - The dream as "guardian of sleep": indications for further research. PMID- 4316517 TI - Does dreaming have a function? PMID- 4316519 TI - Methods for research on sleep deprivation and sleep function. PMID- 4316518 TI - The public (scientific) study of private events. PMID- 4316520 TI - Suggestions for urgently needed research. PMID- 4316521 TI - The scientific study of sleep and dreams. PMID- 4316522 TI - Individual differences in sleep length. PMID- 4316523 TI - Laboratory studies of effects of presleep events on sleep and dreams. PMID- 4316524 TI - The relationship of sleep disturbances to psychopathology. PMID- 4316525 TI - Schwann cell dysfunction in acromegaly. PMID- 4316526 TI - Significance of iodide-perchlorate discharge test for detection of iodine organification defect of the thyroid. PMID- 4316527 TI - Effect of aminophylline on the secretion of insulin, glucagon, luteinizing hormone and growth hormone in humans. PMID- 4316528 TI - Effect of streptozotocin on qualitative aspects of plasma insulin in a patient with a malignant islet cell tumor. PMID- 4316529 TI - Effect of o,p'-DDD on cortisol secretory pattern in Cushing's syndrome. PMID- 4316530 TI - Cochlear nucleus and auditory cortex correlates of a click stimulus-intensity discrimination in cats. PMID- 4316531 TI - Cellular studies of sympathetic denervation produced by 6-hydroxydopamine in the vas deferens. PMID- 4316532 TI - Distribution of histamine in the canine autonomic nervous system. PMID- 4316533 TI - Absence of supersensitivity to acetylcholine in innervated muscle subjected to a prolonged pharmacologic nerve block. PMID- 4316534 TI - Selective renal vascular effects of ethacrynic acid. PMID- 4316535 TI - Potentiation by [4,4'-biphenylenebis(2-oxoethylene)]bis-[2,2-diethoxyethyl) dimethylammonium bromide] (DMAE) of the sympathetic component of the vasopressor response to angiotensin. PMID- 4316536 TI - The effects of debrisoquin and bretylium on adrenergic nerves as revealed by fluorescence histochemistry. PMID- 4316537 TI - [Angiofibroma of the esophagus]. PMID- 4316538 TI - [Differential reaction of lymphocytes to phytohemagglutinin (PHA) in liver diseases]. PMID- 4316540 TI - Repair of x-ray damage in DNA of cultivated cells from patients having xeroderma pigmentosum. PMID- 4316539 TI - [Leukocyte metabolism. IV. Comparative quantitative determination of NAD and ATP of isolated leukocytes and erythrocytes in chronic and acute human leukemias]. PMID- 4316542 TI - [Study on the activity of some enzymes during development of destructive lesions of the lung]. PMID- 4316541 TI - Atypical behaviour of certain viruses. PMID- 4316543 TI - [Usefulness of the "ninhydrin test" in lesions of the brachial plexus and its branches]. PMID- 4316544 TI - Plasma kinins in inflammation--relation to other mediators and leukocytes. PMID- 4316545 TI - Periodical weekly variations of serum bilirubin concentration in women. PMID- 4316546 TI - Radioimmunoassay for angiotensin-II to be used in direct conjunction with renin assay. PMID- 4316547 TI - Estimation of plasma renin concentration using radioimmunoassay of angiotensin. II. PMID- 4316548 TI - Lactate dehydrogenase isozymes: further kinetic studies at high enzyme concentration. AB - By competition with lactate dehydrogenase (LDH) for nicotinamide adenine dinucleotide (NAD), commonly occurring intracellular proteins, such as glyceraldehyde-3-phosphate dehydrogenase, malate dehydrogenase, and albumin, can protect LDH-1 and LDH-5 from inhibition and ternary complex formation with NAD and pyruvate. The existence of intracellular proteins that compete with LDH for NAD renders unphysiological a model for estimating the extent of intracellular LDH inhibition based on incubations of only LDH, NAD, and pyruvate. PMID- 4316549 TI - Cyclic adenosine monophosphate: potassium-dependent action on vascular smooth muscle membrane potential. AB - Dibutyryl cyclic adenosine monophosphate and theophylline hyperpolarize smooth muscle of rabbit main pulmonary artery in low concentrations of potassium (1 millimole per liter) but do not have a significant effect on the membrane potential in the presence of high concentrations of potassium (10 millimoles per liter). The dependence of the hyperpolarizing effect on a low external concentration of potassium is similar to that observed with isoproterenol. Prior treatment with theophylline potentiated the hyperpolarizing action of isoproterenol. These findings are compatible with the assumption that potassium dependent, beta-adrenergic hyperpolarization is mediated by cyclic adenosine monophosphate. PMID- 4316550 TI - [Functional status of the bronchi in influenza and para-influenza]. PMID- 4316551 TI - [Evaluation of roentgeno-morphological data and functional properties of the salivary glands in a neoplastic process]. PMID- 4316552 TI - [Experience in radical operations on the parotid salivary gland]. PMID- 4316553 TI - Collagenase and the cornea. PMID- 4316554 TI - Evidence for ambiguity in the posttranslational cleavage of poliovirus proteins. PMID- 4316555 TI - Magnesium silicate in virus transmission. PMID- 4316556 TI - Defect in poliovirus maturation under hypotonic conditions. PMID- 4316557 TI - Histochemical studies of functional groups of proteins in abnormal forms of glial cells. II. Glial tumors. PMID- 4316558 TI - The leukemogenic action of the Graffi mouse leukemia virus in inbred and randomly bred mouse strains. PMID- 4316559 TI - Cylindroma of salivary glands. A report of 80 cases. PMID- 4316561 TI - Variations in radiosensitivity of various types of malignant salivary-gland tumour. PMID- 4316562 TI - Early diagnosis of 8th-nerve tumours by acoustic reflex tests. PMID- 4316560 TI - Cytological diagnosis of salivary-gland carcinomata from aspiration biopsy smears. PMID- 4316563 TI - Endocrine thermoregulatory responses to local hypothalamic cooling in unanesthetized baboons. PMID- 4316564 TI - Effect of various substances on tensile strength of sow ovarian follicles. PMID- 4316565 TI - Malignant salivary gland tumours of the nose and exophthalmos in children. PMID- 4316566 TI - [Peptic ulceration in adolescents and their biological age]. PMID- 4316568 TI - [After care in heart infarct]. PMID- 4316567 TI - [Preventive studies on a fat embolism model using phosphatide infusions]. PMID- 4316569 TI - Effect of growth hormone on cortisone-induced hyperinsulinemia and reduction in pancreatic insulin in the mouse. PMID- 4316570 TI - Effects of beta-MSH, cortisol and ACTH on tyrosinase in the skin of newborn hamsters and mice. PMID- 4316571 TI - Cyclic-AMP production of goiter. PMID- 4316572 TI - Effect of glucagon, cyclic 3',5'-adenosine monophosphate and its dibutyryl derivative on amino acid uptake by the isolated perfused rat liver. PMID- 4316573 TI - Suppression of ACTH release from adenophypophysis by corticosterone: an in vitro study. PMID- 4316574 TI - Glycogenolytic activity of cyclic 3',5'-monophosphates in perfused rat liver. PMID- 4316575 TI - Role of calcium ions in the release of ACTH from rat pituitary tissue in vitro. PMID- 4316576 TI - Effect of pentolinium on ACTH stimulation of renin release. PMID- 4316578 TI - Surgical considerations in pancreatic hypoglycemia. PMID- 4316577 TI - [Properties of the olfactory bulb dendrites in the frog]. PMID- 4316579 TI - Effect of magnesium ions on neuromuscular transmission in the horse, steer, and dog. PMID- 4316580 TI - Serologic response to a formalized and adjuvanted parainfluenza-3 antigen in calves. PMID- 4316581 TI - Immunologic behavior of follicle-stimulating hormone extracted from postmenopausal urine and the pituitary. PMID- 4316582 TI - Progesterone, pregnancy and the augmented plasma insulin response. PMID- 4316583 TI - Photoelectric method for quantitative evaluation of mast-cell-associated enzyme activity in human gingival tissues. PMID- 4316584 TI - Lymphangiogram of Meigs' syndrome. Report of a case. PMID- 4316585 TI - Incidence and relative frequency of benign and malignant ovarian neoplasms. PMID- 4316586 TI - Mechanoreceptor function. PMID- 4316587 TI - [On the treatment of myasthenia]. PMID- 4316588 TI - [Suitable management of patients following thyroidectomy]. PMID- 4316589 TI - The participation of "short" feedback mechanisms in the control of ACTH and TSH secretion. PMID- 4316590 TI - [Morphologic and experimental bases of hypothalamic neurosecretion]. PMID- 4316591 TI - [Isolation of a strain of Myxovirus parainfluenzae 1 in a human embryo delivered during a febrile abortion]. PMID- 4316592 TI - [Cytogenetic and hematologic evolution of an infant irradiated in utero]. PMID- 4316593 TI - [A typical sclerosing hemangiomatosis. Considerations on a case resembling Maffucci's syndrome]. PMID- 4316594 TI - Equine herpes viruses. 2. Persistence of equine herpesviruses in experimentally infected horses and the experimental induction of abortion. PMID- 4316595 TI - [Vesicular stomatitis as a zoonosis]. PMID- 4316596 TI - Function of smooth muscle of the rat renal pelvis--response of the isolated pelvis muscle to angiotensin and some other substances. AB - 1. The circular component of the renal pelvis muscle of the rat appears as an intact band around the tip of the papilla.2. The isolated pelvis muscle strip showed spontaneous rhythmic contractions in Locke solution at 38 degrees C. The rate of contractions corresponded with the rate of pressure fluctuations recorded during free-flow from a ureteral catheter inserted up to the renal hilum of anaesthetized rats.3. Angiotensin and adrenaline (13 ng/ml) produced a rise in tone of the isolated pelvis muscle, and an increase in the rate of spontaneous contractions; noradrenaline produced mainly an increase in the amplitude and rate of spontaneous contractions. Angiotensin and noradrenaline injected intravenously also produced an increased rate of pressure fluctuations recorded from the ureteral catheter.4. Acetylcholine, nicotine and 5-hydroxytryptamine had no effect on the isolated tissue, but isoprenaline was capable of causing a decrease, and tyramine an increase, in the rate of spontaneous contractions in high dose (0.33 mug/ml).5. An increase in the tone of the circular pelvis muscle could lead to a reversible obstruction of urine outflow from the kidney. PMID- 4316598 TI - Immunology of the mouse mammary tumor virus: comparison of the antigenicity of mammary tumor virus obtained from several strains of mice. PMID- 4316597 TI - Renal tubular flow dynamics during angiotensin diuresis in the rat. AB - 1. Tubular size and lissamine green transit times were measured in rat kidneys undergoing a diuretic response to angiotensin II (0.5 mug/kg per min), and compared with the changes observed during diuresis induced by osmotic diuretics, noradrenaline and chlorothiazide.2. Angiotensin always caused a marked prolongation in proximal and distal tubular transit times; individual distal convolutions were coloured for prolonged periods, and lissamine green appeared in high concentration in distal tubules.3. Marked changes were observed in superficial tubular calibre during a stable diuretic response to angiotensin. Where distal tubular diameter was normal for the rate of urine flow, proximal tubular volume was generally reduced. In a number of experiments, however, distal tubules were markedly dilated, and in these cases proximal tubular volume was also often increased. Angiotensin may therefore be capable of causing a degree of internal hydronephrosis in the rat kidney.4. Prolongation of dye transit times, and the appearance of a concentrated lissamine green bolus in distal tubules, was suggestive of a decreased superficial nephron flow rate, indicating that the diuretic effect of angiotensin may take place only through deeper nephrons. PMID- 4316599 TI - Quantitative aspects of thymidine uptake into the acid-souble pool of normal and polyoma-transformed hamster cells. PMID- 4316600 TI - Biological and morphological studies of SJL-J strain reticulum cell neoplasms induced and transmitted serially in low-leukemia-strain mice. PMID- 4316601 TI - Influence of toyocamycin on avian leukemia myeloblasts: cell growth, ultrastructure, RNA synthesis, and elaboration of BAI strain A virus. PMID- 4316602 TI - 32P distribution in oligonucleotides of 28 S ribosomal RNA of the Novikoff hepatoma and normal rat liver. PMID- 4316604 TI - The cell cycles of three transplantable Morris hepatomas. PMID- 4316603 TI - Comparative studies on nuclei and chromatin of hepatomas and rat liver. PMID- 4316605 TI - Two distinct types of SV40-transformed human amnion cells. PMID- 4316606 TI - A study of two types of ferritin from rat hepatomas. PMID- 4316607 TI - [What is certain in the therapy of liver patients?]. PMID- 4316608 TI - [Diagnosis and differential diagnosis of Cushing's syndrome]. PMID- 4316609 TI - Factors determining the success or failure of nephrectomy in experimental renal hypertension. PMID- 4316610 TI - Cardiostimulatory effects of cyclic 3',5'-adenosine monophosphate and its acylated derivatives. PMID- 4316611 TI - Changes in the production of avian sarcoma virus B77 after reinoculation of the virus producing cell line l7RBI77 into the host. PMID- 4316612 TI - Avian leukosis sarcoma virus group specific antigens in heteroinduced rat tumours. PMID- 4316613 TI - Interaction of baroreceptor afferents from carotid sinus and aorta at the nucleus tractus solitarii. PMID- 4316614 TI - [Remote results of pulmonary tuberculosis therapy with antitubercular agents and corticotropin]. PMID- 4316615 TI - Contribution to the comparative morphology, electron microscopy, enzymology and biochemistry of cardiac, red and white muscles of the hen (Gallus domesticus). PMID- 4316616 TI - [Elbow neoplasms]. PMID- 4316617 TI - Ecology of Japanese encephalitis virus on Taiwan in 1968. PMID- 4316618 TI - Double-stranded RNAs (poly I:C) in the prevention of viral infections. PMID- 4316619 TI - Applied and induced interferon in the prophylaxis and treatment of leukemia. PMID- 4316620 TI - [Tuberculosis. Experience in the developping countries]. PMID- 4316621 TI - The genetic basis of cross-resistance between streptomycin, viomycin and kanamycin of tubercle bacilli and atypical mycobacteria. PMID- 4316622 TI - [Influence of epidemiologic factors on the histological structure of bronchial carcinoma]. PMID- 4316623 TI - [Effect of exogenous angiotensin II on blood pressure in experimental nephrogenic and neurogenic-interoreceptive hypertension of rats]. PMID- 4316624 TI - [Comparative studies on cardiac stimulus formation disturbances in normotonic and hypertonic rabbits during administration of synthetic angiotensin II]. PMID- 4316625 TI - [Analysis of effect of catecholamines and serotonin on vegetative ganglia]. PMID- 4316626 TI - [Peculiarities of tachyphylactic properties of some analogues of angiotensin II]. PMID- 4316627 TI - [Effect of apressin on oxygen consumption, tissue respiration and activity of some oxidoreductases in intact and hypoxic rats]. PMID- 4316628 TI - Duplication of the index finger. PMID- 4316629 TI - Bronchiolar carcinoma. PMID- 4316630 TI - [Use of leukocyte interferon for the prevention and treatment of several viral infections]. PMID- 4316631 TI - [Diagnosis of glomangiomas (Barre-Masson tumors)]. PMID- 4316633 TI - [Characteristics of cell contact in hepatomas with minimal deviation (Gel'shtein's hepatoma)]. PMID- 4316632 TI - [Analysis of tumor transformation in tissues. II. Biochemical dedifferentiation in the process of cancerogenesis (changes in creatine kinase and alkaline phosphatase as an example)]. PMID- 4316634 TI - [The interrelationship between the clinical features and morphologic brain changes in the propulsive form of epilepsy]. PMID- 4316635 TI - [The effect of superficial polarization on the intracellular activity of neurons of the motor zone of the cortex in awake rabbits]. PMID- 4316636 TI - Repetition-sensitive soma-response to de- and hyperpolarization of an identified Helix-neuron. PMID- 4316637 TI - A study of the stress reaction elicited by muscular exertion in trained and untrained man and rats. PMID- 4316638 TI - In vitro steroid production by the adrenal gland of intact rats and rats subjected to surgical stress. PMID- 4316639 TI - The acute effect of hypophysectomy on tissue blood flow and oxygen consumption of the adrenal cortex and medulla in dogs. PMID- 4316640 TI - Effect of chronic enhancement of TSH secretion on pituitary-adrenal function in the rat. PMID- 4316641 TI - The effect of dehydrobenzperidol and fentanyl on corticosteroid secretion and the stress-induced ACTH-release in the rat. PMID- 4316642 TI - Magnesium ion blockade of regional vasoconstriction. PMID- 4316643 TI - Pulmonary resection for metastasis in nonbeta islet cell tumor of pancreas. PMID- 4316645 TI - [Renewal of vitamin D]. PMID- 4316646 TI - [Association of congential toxoplasmosis and cytomegaly in infants. Study of 2 anatomoclinical cases]. PMID- 4316644 TI - A study of insulin secretion in thoracic duct lymph of the dog. PMID- 4316647 TI - [Inactivation and radical formation following UV-irradiation of trypsin in suspension]. PMID- 4316648 TI - [Reaction kinetics of radiation-induced free radicals of glycyl-DL-valine and DL valyl-glycine during heat treatment and UV-irradiation]. PMID- 4316649 TI - [The association of aniridia with tumor of the kidney in children. 4 cases]. PMID- 4316650 TI - "Unrealistic" discharges. PMID- 4316651 TI - [Importance of stapolidex in infectious dermatoses]. PMID- 4316652 TI - [Antiviral chemotherapy in dermatology. Action of N1, N1 anhydrobis (beta hydroxyethyl) biguanide hydrochloride in high doses]. PMID- 4316653 TI - Changes in release, re-uptake and subcellular distribution of noradrenaline in the spleen of renal hypertensive dogs. PMID- 4316654 TI - [Carcinogenic effect of 4,4'-diaminodiphenylmethane and 2,4' diaminodiphenylmethane]. PMID- 4316655 TI - [Influence of chloramphenicol upon liver cancerization caused by diethylnitrosamine]. PMID- 4316656 TI - A study of the renin-angiotensin system in patients with severe chronic renal insufficiency. PMID- 4316658 TI - [Hypertrophic osteoarthropathy (HOA) and paraproteinemia as paraneoplastic primary and secondary manifestations of a bronchiopulmonary carcinoma]. PMID- 4316657 TI - [Thymo-lymphatic atrophy in an infant following long-term ACTH therapy]. PMID- 4316659 TI - [Ultrastructural study of a transplantable mouse "granular cell myoblastoma"]. PMID- 4316660 TI - [Hepatic enzymohistochemical aspects in benign evolution of viral hepatitis]. PMID- 4316662 TI - [Thecoma in the ovary and Meigs' syndrome]. PMID- 4316661 TI - [Flupenthixol in depot form--a new remedy in psychiatric after-care]. PMID- 4316663 TI - Changes in the ultrastructure and number of platelets induced by an adrenochrome complex. PMID- 4316664 TI - The blood pressure response following angiotensin in nephrectomized, urethanized rats. PMID- 4316665 TI - Chemotherapy in the treatment of cancer of the ovary. PMID- 4316666 TI - Antibodies to genital herpesvirus in patients with carcinoma of the cervix. PMID- 4316667 TI - Catecholamines, a dream sleep model, and depression. PMID- 4316668 TI - Adrenal cytomegaly: studies by light and electron microscopy. Comparison with the adrenal in Beckwith's and virilism syndromes. PMID- 4316669 TI - [Fibularis paralysis in orthopedics]. PMID- 4316670 TI - [Intravenous ACTH quick test]. PMID- 4316671 TI - Dental and skeletal development in various endocrine and metabolic diseases. PMID- 4316672 TI - The quantitative separation of 3',5'-cyclic adenosine monophosphate, adenosine-5' monophosphate, adenosine-5'-diphosphate, and adenosine-5'-triphosphate by ion exchange chromatography on diethylaminoethyl sephadex. PMID- 4316673 TI - Premature deciduous tooth loss in hypophosphatasia. PMID- 4316674 TI - An in vitro effect of triiodothyronine on lipolysis, cyclic AMP-C14 accumulation and oxygen consumption in isolated fat cells. PMID- 4316675 TI - Ethanol-induced hypoglycemia in thyroxine-treated rats. PMID- 4316676 TI - [Mixed acute respiratory virus infections in young children]. PMID- 4316677 TI - Relationship of a membrane-bound D-(-)-lactic dehydrogenase to amino acid transport in isolated bacterial membrane preparations. AB - The conversion of D-lactate to pyruvate in isolated membrane preparations of E. coli ML 308-225 markedly stimulates the transport of proline, glutamic acid, aspartic acid, aspargine, tryptophan, lysine, serine, alanine, and glycine. The uptake of histidine, phenylalanine, tyrosine, leucine, isoleucine, and valine by the membranes is also markedly stimulated by this conversion, although these amino acids are taken up much less effectively than those mentioned previously. The uptake of arginine, methionine, cystine, and cysteine is enhanced only about twofold in the presence of D-(-)-lactate, and these amino acids are not concentrated well by the membranes. With the exception of glutamate, asparate, asparagine, and methionine, which are converted to other metabolites to varying extents in the intramembranal pool, each of the other amino acids was recovered from the membranes as the unchanged amino acid. Succinate, L-(+)-lactate, D,L alpha-hydroxybutyrate, and DPNH partially replace D-(-)-lactate but are less effective. PMID- 4316678 TI - Excitatory postsynaptic potential and monosynaptic reflex discharge of spinal motoneurons during anoxic insult. AB - Almost universally held is the concept that in transmission from one neuron to another the so-called postsynaptic potential is the essential step leading to discharge of the secondary neurons. According to the present experiments this is not so in the monosynaptic reflex system of the cat spinal cord. Its role in facilitation of response and certain other essential data are mentioned. PMID- 4316679 TI - Electron paramagnetic resonance studies of spin-labeled hemoglobins and their implications to the nature of cooperative oxygen binding to hemoglobin. AB - The spin label technique has been used to study human hemoglobins A, F, Zurich, and Chesapeake as a function of carbon monoxide saturation. The experimental results suggest that the changes in the electron paramagnetic resonance spectra of hemoglobin labeled with N-(1-oxyl-2,2,6,6-tetramethyl-4 piperidinyl)iodoacetamide depend on the state of ligation of more than one heme group. For those hemoglobins with full or large cooperative ligand binding (such as A, F, and Zurich), there is a lack of isosbestic points in the spectra as a function of CO saturation. However, for those hemoglobins with little or no cooperative ligand binding (such as Chesapeake and methemoglobins), there is a sharp set of isosbestic points. These findings confirm and extend the early work of McConnell and co-workers. The absence of a set of isosbestic points in those hemoglobins with full cooperative ligand binding is consistent with the sequential model of Koshland, Nemethy, and Filmer for cooperative oxygen binding to hemoglobin. The present results, with hemoglobin variants having known amino acid substitutions, also focus on the importance of the interactions among the amino acid residues located at alpha(1)-beta(2) or alpha(2)-beta(1) subunit contacts for the functioning of hemoglobin as an oxygen carrier. In addition, the resonance spectra of the spin label are very sensitive to small structural variations around the heme groups in the beta- or gamma-chains where the labels are attached. The results of the spin label experiment are discussed in relation to recent findings on the mechanism of oxygenation of hemoglobin from the nuclear magnetic resonance studies of this laboratory and the x-ray crystallographic analysis of Perutz and co-workers. PMID- 4316680 TI - Proteins specified by herpes simplex virus, IV. Site of glycosylation and accumulation of viral membrane proteins. AB - The membrane glycoproteins specified by herpes simplex virus are synthesized concurrently with structural viral proteins and accumulate in the cytoplasm and in the membranes lining it. Analyses of free and membranebound polyribosomes, the cytoplasmic pool of soluble proteins, and purified smooth membranes showed that viral membrane proteins bind to membranes soon after synthesis and become glycosylated in situ. PMID- 4316682 TI - Mitochondrial longevity in vitro: the retention of respiratory control. AB - Isolated mitochondria were maintained metabolically active and coupled, i.e., capable of respiratory control, for several hours at 25 degrees C. An increase in respiratory control generally occurred during the first 4-8 hr of incubation followed thereafter by a decline. Longevity is a dynamic function as evidenced by its dependency on substrate and cofactors, thiamine pyrophosphate, in particular. Magnesium was also essential to longevity; coenzyme A, bovine serum albumin, and reducing agents were not. The findings are discussed in terms of cytoplasmic mitochondrial interrelationships and mitochondrial autonomy. PMID- 4316681 TI - Inactivating and mutagenic effects of nitrosoguanidine on simian virus 40. AB - N-methyl-N'-nitro-N-nitrosoguanidine (NTG) in high concentrations inactivates extracellular simian virus 40. No mutants were found in stocks of virions partially inactivated by NTG under the experimental conditions employed. In contrast, NTG in low concentrations inhibits the intracellular replication of simian virus 40 and is an effective mutagen of the intracellular virus. Six temperature-sensitive mutants of simian virus 40 have been isolated for genetic studies of the virus and its interaction with mammalian cells. PMID- 4316683 TI - Membrane structure: spin labeling and freeze etching of Mycoplasma laidawii. AB - A spin-labeled fatty acid was incorporated in vivo into the polar lipids of Mycoplasma laidlawii membranes. The electron paramagnetic resonance signal from either intact cells or their extracted lipids reflected the fatty acid composition of the Mycoplasma membranes. Comparison of signals from intact cells, gramicidin-treated cells, heat-treated cells, and extracted lipids indicates that a major portion of the membrane lipids is in a semiviscous hydrocarbon environment. The results also show that the spin label in the intact membrane is slightly but significantly less mobile than it is in protein-free lipid extracts made from these membranes. Correlated electron microscope examinations using the freeze-etch technique reveal particulate components in the hydrophobic region of the membrane. The mobility of the lipids in the intact cell membrane may be influenced by their association with these particles. PMID- 4316685 TI - [Liver surgery]. PMID- 4316686 TI - [Effects of the unfractionated histone from the calf thymus upon the development of the Rous sarcoma in chicken]. PMID- 4316684 TI - Glucocorticoid regulation of ACTH sensitivity of adenyl cyclase in rat fat cell membranes. AB - Plasma membrane sacs of isolated rat fat cells (ghots) possess an adenyl cyclase system, which is activated by lipolytic hormones of disparate molecular structure, including adrenocorticotropin (ACTH), glucagon, and epinephrine. Previous studies indicated that distinctive selectivity units for individual hormones are coupled to the same unit of adenyl cyclase in the fat cell membrane. The present study has shown that ghost cyclase from adrenalectomized and hypophysectomized rats exhibits a striking reduction in response to ACTH, the stimulatory effects of epinephrine, glucagon, or fluoride being unchanged. Pretreatment of adrenalectomized, hypophysectomized, sham operated, or intact rats with the synthetic glucocorticoid, dexamethasone, selectively increased the ACTH response in ghost cyclase preparations. Cortisol, like dexamethasone, increased the ACTH response in ghosts from adrenalectomized rats; 11 deoxycorticosterone was ineffective. The dexamethasone effect to enhance the ACTH response is blocked by actinomycin D or cycloheximide. The present results show that stimulation of rat fat cell adenyl cyclase by ACTH involves a distinctive molecular entity, which can be clearly differentiated from adenyl cyclase in the membrane as well as from the selectivity sites for epinephrine and glucagon. The data indicate that the biosynthesis of the component required for ACTH stimulation of ghost cyclase-either an ACTH selectivity unit or specific coupling factor-is induced by glucocorticoids at the level of gene regulation. PMID- 4316687 TI - [Biochemical and morphological studies on the toxicity of chlorotrifluoroethylene (CTFA)]. PMID- 4316688 TI - [Schmidt's syndrome and diabetes mellitus]. PMID- 4316689 TI - [About the relations between dermatomyositis and malignant tumours]. PMID- 4316690 TI - The behaviour of two strains of murine sarcoma virus in vitro. PMID- 4316691 TI - The lipid composition of the blood of marine mammals. I. Young elephant seals, Mirounga augustirostris and harp seals, Pagophilus groenlandicus. PMID- 4316693 TI - [Protective and toxic effects of Bordetella pertussis spheroplasts in animal experiments]. PMID- 4316692 TI - [Significance of the thymus gland for neoplasms and leukemogenesis. A review]. PMID- 4316694 TI - [Plasma glucose concentration following experimental interventions in blood pressure homeostasis of rabbits. I. Effect of synthetic angiotensin II on the blood sugar level of normotonic and renal hypertonic experimental animals]. PMID- 4316695 TI - [Influence of the preparation technic on insulin secretion by isolated islands of Langerhans in vitro]. PMID- 4316696 TI - [Enzyme histochemical findings in the ultimobranchial body of the horse]. PMID- 4316697 TI - Pituitary function in the elderly. PMID- 4316698 TI - [Age determination with biologic tests]. PMID- 4316699 TI - Reduced nicotinamide adenine dinucleotide oxidase of Streptococcus diacetilactis. PMID- 4316700 TI - Changes in polysomes of the developing rat brain. PMID- 4316701 TI - The influence of deprivation of paradoxical sleep on cerebral ammonia metabolism. PMID- 4316702 TI - The effect of N-methyl-4-piperidyl-diphenyl glycolate on the incorporation of 32P into phospholipids from rat brain cortex slices and its subcellular localization. PMID- 4316703 TI - The protein composition of isolated myelin. PMID- 4316704 TI - 2',3'-cyclic nucleotide 3'-phosphohydrolase in brains of mutant mice with deficient myelination. PMID- 4316705 TI - Primary adenocarcinoma of the renal pelvis: report of a case. PMID- 4316707 TI - [Discussions on the role of viral hepatitis in the onset of chronic medullary insufficiency]. PMID- 4316706 TI - [Effect of the liver on experimental renal hypertension due to intrarenal causes]. PMID- 4316708 TI - [Statistical analysis of remote results of the treatment of patients with mixed tumors of the parotid gland]. PMID- 4316710 TI - [Certain mechanisms of reaction of the adrenal cortex in rats subjected to injury by polonium-210]. PMID- 4316709 TI - Mechanism of transmitter release. PMID- 4316711 TI - [Sites of endemic trachoma on the Ivory Coast]. PMID- 4316712 TI - Cell surface coatings and membrane potentials of malignant and nonmalignant cells. AB - A positive surface potential indicating a cell coating is common to malignant cells, lymphocytes, and normal and malignant trophoblastic cells. This characteristic was not generally found for other normal cell types tested by microelectrode penetration. PMID- 4316713 TI - The binding of luxol fast blue ARN by various biological lipids. PMID- 4316714 TI - [Activity of enzymes of energy metabolism in normal human skin]. PMID- 4316716 TI - Neurogenous nasal neoplasms. PMID- 4316715 TI - Viral myocarditis during pregnancy: encephalomyocarditis virus infection in mice. PMID- 4316717 TI - Mucous gland tumors of the nose and paranasal sinuses. PMID- 4316718 TI - Pathogenesis of rhinovirus common colds in human voluteers. PMID- 4316719 TI - Angiography of the nose and surrounding cavities. PMID- 4316720 TI - The rhinoviruses of man. PMID- 4316721 TI - Recurrent parotid tumours. PMID- 4316722 TI - [Biochemistry of brain tumors]. PMID- 4316723 TI - [Isolation of foot-and-mouth disease virus in sheep]. PMID- 4316724 TI - [Infectious bovine rhinotracheitis: isolation of the virus at the occasion of an enzootic observed in the department of Aube]. PMID- 4316725 TI - [Experimental study of Teschen's disease. Isolation and identification of 2 strains of virus in France]. PMID- 4316726 TI - Mesotheliomas of peritoneum, epicardium, and pericardium induced by strain MC29 avian leukosis virus. PMID- 4316727 TI - Histochemical studies on rat liver proteins during 4-dimethylaminoazobenzene carcinogenesis. PMID- 4316728 TI - Fine structure of nuclear inclusions in murine pulmonary tumor cells. PMID- 4316730 TI - Arginine incorporation into proteins by supernatant fractions of rat liver and Novikoff hepatoma. PMID- 4316729 TI - Structure-activity relationships of N-acylarylhydroxylamines in the rat. PMID- 4316731 TI - A study of the carcinogenicity of a series of structurally related 4 dimethylaminoazobenzenes. PMID- 4316732 TI - Detection of SV40-induced T antigen in peripheral leukocytes of tumor-bearing hamsters. PMID- 4316733 TI - Virus particles in rat leukemias. PMID- 4316735 TI - Determination of soil phosphatase activity by a fluorimetric technique. PMID- 4316734 TI - Serum enzymes in chronic hemodialysis. PMID- 4316736 TI - Electrical impedance changes in many sites of brain in paradoxical sleep, anesthesia, and activity. PMID- 4316737 TI - Sleep in the moles, Scalopus aquaticus and Condylura cristata. PMID- 4316738 TI - Study of microscopic degradation in teeth. PMID- 4316740 TI - Glioblastoma multiforme with extracranial metastases in the absence of previous craniotomy. Case report. PMID- 4316739 TI - A comparative study of histoenzymic concentrations of glioblastomas, meningiomas, acoustic neurinomas and chromophobe adenomas. PMID- 4316741 TI - The respiratory chain of plant mitochondria. V. Reaction of reduced cytochromes a and a3 in mung bean mitochondria with oxygen in the presence of cyanide. AB - The half-times of oxidation by oxygen pulses of reduced cytochromes a and a(3) in mung bean mitochondria made anaerobic with succinate have been measured by means of a rapid mixing flow apparatus coupled to a dual wave length spectrophotometer in the presence and absence of cyanide. The absorbance changes at 438 to 455 millimicrons and 603 to 620 millimicrons are suitable for recording the time course of cytochrome a oxidation; the half-time is 2.0 milliseconds at 24 Celsius. This half-time does not change over the range 0 to 300 mum KCN, but the fraction of cytochrome a oxidized falls to a limiting value of 0.3 at the higher cyanide concentrations. The absorbance changes at 445 to 455 millimicrons record the time course of both cytochrome a and cytochrome a(3) oxidation; the former contributes 60% of the absorbance change and the latter 40%. The half-time for a(3) oxidation is calculated as 0.9 milliseconds at 24 Celsius. This half-time increases slightly to 1.3 milliseconds at 300 mum KCN. Reduced cytochrome a(3), whether uncomplexed or complexed with cyanide, becomes fully oxidized. The dissociation constant for the reduced cytochrome a(3)-cyanide complex is estimated to be 30 mum, whereas that for the oxidized a(3)-cyanide complex which inhibits electron transport is estimated to be 2 mum. This suggests two different binding sites for cyanide on the reduced and oxidized forms of cytochrome a(3). The fact that a limiting fraction of reduced cytochrome a can be oxidized at high cyanide concentrations implies that there is no interference by cyanide with electron transport from a to a(3), if cyanide remains bound to the site it occupies on reduced a(3) after this carrier becomes oxidized on reaction with molecular oxygen. Rearrangement of cyanide from this noninhibitory site to the inhibitory site occurs rapidly enough to compete with cytochrome a oxidation. The half-time for the rearrangement is calculated to be 0.9 milliseconds. PMID- 4316742 TI - The pathophysiology and bio-assay of the renin-angiotensin system. PMID- 4316743 TI - Physiological highlights of the Fourth International Congress of Nephrology, Stockholm, 1969. PMID- 4316744 TI - The pharmacological basis of drug dependence. PMID- 4316745 TI - A home-care programme for elderly patients in Johannesburg. PMID- 4316747 TI - Destructive lesions of the sphenoid. PMID- 4316746 TI - Treatment of tumors of minor salivary glands. PMID- 4316748 TI - [Attapulgite: an unusual argillaceous mineral]. PMID- 4316749 TI - [The surgical treatment of myasthenia]. PMID- 4316750 TI - [The role of thiamine and pyridoxine in acute and subacute poisoning due to the phosphororganic insecticide Dipterex]. PMID- 4316751 TI - [Effect of various methods of storage and heat processing on muscle lipids of the mirror carp]. PMID- 4316752 TI - [Study of complement-fixing antibodies to adenoviruses in patients with infectious hepatitis]. PMID- 4316753 TI - [The collagen of the byssus in Mytilus edulis L. II. Autoradiographic study on the incorporation of 3H-proline]. PMID- 4316754 TI - [Morphologic changes in the genitalia of white rats under the influence of silica dust]. PMID- 4316755 TI - The distribution on MAK columns of nucleic acids isolated from different strains of mycobacteria. PMID- 4316756 TI - Mechanism of conjugation and recombination in bacteria. X. The role of donor DNA and of excision-repair mechanism in genetic recombination. PMID- 4316757 TI - The association of viruses and bacteria with infantile diarrhea. PMID- 4316758 TI - Correlations of midshaft breadths and compact bone thickness among bones of the upper and lower extremities of children aged 6 to 16 years. PMID- 4316759 TI - [Development of the laryngeal paraganglion in humans]. PMID- 4316760 TI - [Trials of vaccination of pigs with vaccines of inactivated foot-and-mouth disease (FMD) virus. II. Trials with ethyl ethyleneimine (EEI) inactivated virus and diethylaminoethyl dextran as an adjuvant]. PMID- 4316761 TI - The nature of toxins of herpes simplex virus. II. Quantitation of pyrogenicity and lethality following intracerebral injection of herpes simplex virus in young rabbits. PMID- 4316762 TI - Replicative forms of Sendai virus RNA. PMID- 4316763 TI - Adverse effect of thiadiazolylcarbamic acid esters on measles and polio viruses in Vero cells. Brief report. PMID- 4316765 TI - Feather follicle epithelium: a source of enveloped and infectious cell-free herpesvirus from Marek's disease. PMID- 4316764 TI - [Primary character of the origin of bilateral breast cancer (clinico-morphologic characteristics)]. PMID- 4316766 TI - Studies on the epidemiology of Marek's disease herpesvirus in broiler flocks. PMID- 4316767 TI - Coronaviruses, a new group of animal RNA viruses. PMID- 4316768 TI - Hematopoietic destruction in Marek's disease. PMID- 4316769 TI - Aspects of the pharmacology of local anaesthetic agents. PMID- 4316770 TI - [Factors of restoration of synaptic transmission of visual influx in lateral geniculate body]. PMID- 4316771 TI - [Kinetics of the development of Rous sarcoma virus (Schmidt-Ruppin strain). Incorporation of uridine and arginine in associated intracytoplasmic particles. Study with high resolution autoradiography]. PMID- 4316772 TI - [Possibility to use passive hemagglutination test for diagnosis of hypodermyiasis, using as antigen a raw collagenase extracted from 1st stage larvae of Hypoderma lineatum]. PMID- 4316773 TI - Polarographic investigation on tetrazolium reductase activity. PMID- 4316774 TI - [Chemodifferentiation of the rat visual pathway. Morphologic, histochemical and experimental studies]. PMID- 4316775 TI - On the mechanism of action of adrenocorticotropic hormone. Stimulation of deoxyribonucleic acid polymerase and thymidine kinase activities in adrenal glands. PMID- 4316776 TI - Demonstration of three specific sites on the surface of foot-and-mouth disease virus by antibody complexing. PMID- 4316777 TI - Rescue of heat-inactivated adenovirus type 1 and 6 by ultraviolet-irradiated adenovirus type 8. PMID- 4316778 TI - Preparation of immune rabbit sera with neutralizing activity against human cytomegalovirus and varicella-zoster virus. PMID- 4316779 TI - Replication of Rous sarcoma virus in synchronized cells. PMID- 4316780 TI - Vesicular stomatitis virus maturation sites in six different host cells. PMID- 4316781 TI - Family Centered Maternity Care emphasizes homelike atmosphere. PMID- 4316782 TI - Horn L: Nursing's silent majority. PMID- 4316783 TI - Adenocystic carcinoma--oral cavity. PMID- 4316784 TI - [Ceruloplasmin activity in various clinical forms of bronchial asthma and during ACTH, hydrocortisone, and deseril administration]. PMID- 4316786 TI - [Opacification of the spinal cord, its covering membranes, its roots]. PMID- 4316785 TI - Current trends in Australian neurology. PMID- 4316787 TI - Abnormalities in skin potential fluctuations during the sleep of acute schizophrenic patients. PMID- 4316788 TI - Differential reactivity of human serums with early antigens induced by Epstein Barr virus. AB - Inoculation of 64-10 or Raji cultures with Epstein-Barr virus derived from the HRI-K clone of the P3J Burkitt's lymphoma line caused abortive infections in most of the lymphoblastoid cells with synthesis of "early antigens" but few, if any, capsids. Antibodies to early antigens were detected by indirect immunofluorescence in serums of many patients with infectious mononucleosis, Burkitt's lymphoma, or nasopharyngeal carcinoma. These antibodies were rarely present in other serums even though some of them showed high titers of antibodies to Epstein-Barr virus when assayed on EB3 Burkitt tumor cells; they also prevented synthesis of early antigens, provided the serums were mixed with the virus prior to inoculation. Antibodies to early antigens possibly reflect current or recent disease processes that are associated with the virus. PMID- 4316789 TI - [Irreversible coma and brain death. Study of 71 cases]. PMID- 4316790 TI - [Serologic study of Mycoplasma pneumoniae infections by metabolic inhibition test. Study of 114 pairs of serums from patients with pneumonia]. PMID- 4316791 TI - [The phosphate ion in biology and therapy]. PMID- 4316792 TI - [Relationship between electro-encephalic changes and the neuro-mental state in hepatic encephalopathy]. PMID- 4316793 TI - [Indications for corticotherapy in epidemic hepatitis associated with diabetes mellitus]. PMID- 4316794 TI - [How to supervise a patient with respiratory insufficiency]. PMID- 4316795 TI - [Hormone-producing tumors of the lung. A review]. PMID- 4316796 TI - [Hormone-producing tumors of the lung. 3 cases]. PMID- 4316797 TI - [A new animal for experimental oncologic research--the Dzhungarian hamster]. PMID- 4316798 TI - Experiments for the detection of Rous-sarcoma virus neutralizing antibodies by a chorionallantois membrane test. PMID- 4316800 TI - Superior vena caval obstruction with lung cancer. PMID- 4316799 TI - Infectivity and pathogenicity of drug-resistant strains of tubercle bacilli studied by aerogenic infection of guinea pigs. PMID- 4316801 TI - Simultaneous occurrence of histologically different tumors in the same lung. PMID- 4316803 TI - Epidemic malaise. PMID- 4316802 TI - Tarsal-tunnel syndrome, a presenting feature of rheumatoid arthritis. PMID- 4316804 TI - Infectious disease epidemiology. Viruses associated with bronchiolitis and croup during 1969. PMID- 4316805 TI - [Prevention of rickets in newborn infants]. PMID- 4316806 TI - Cytomegalovirus and the post-transfusion syndrome. PMID- 4316807 TI - Post-treatment care of patients with pelvic malignancy. PMID- 4316808 TI - The use of an aerosol antibiotic in minor surgery. PMID- 4316810 TI - The rhinoviruses of man. PMID- 4316809 TI - [Immunosuppressive agents in hematology]. PMID- 4316811 TI - [Succinate oxidation in mitochondria]. PMID- 4316812 TI - [On the possibility of donor-acceptor interactions in biological systems]. PMID- 4316813 TI - [A heavy leg: a case of synovial sarcoma]. PMID- 4316814 TI - [Chondrodysplasic rheumatism]. PMID- 4316815 TI - [Multiple subcutaneous plasmocytosarcoma (1 case)]. PMID- 4316816 TI - [Study of 226 cases of acute benign lymphocytic meningitis]. PMID- 4316817 TI - [A common heart disease in young patients. Subaortic muscular stenosis]. PMID- 4316818 TI - [Treatment of advanced stage of cancer of the breast with 2-alpha methyl dihydrotestosterone propionate (CS 1507]. PMID- 4316819 TI - [The beginnings of cardiology]. PMID- 4316820 TI - [Clinical study of a psychotropic drug: sulpiride in attempted suicide without psychosis]. PMID- 4316821 TI - [Our clinical experience with sulpiride in psychiatry]. PMID- 4316822 TI - [Considerations on 30 patients treated with sulpiride]. PMID- 4316823 TI - [Sulpiride in psychiatric treatment. Clinical and psychometric study in 58 patients]. PMID- 4316824 TI - [Use of sulpiride in organic and functional digestive pathology]. PMID- 4316825 TI - [Sulpiride in neuro-respiratory resuscitation and in internal medicine. Prevention of corticotherapeutic ulcer]. PMID- 4316826 TI - [Digestive mucosa and conditions of distress. Efficacy of protective treatment with sulpiride]. PMID- 4316827 TI - [Ulcero-hemorrhagic rectocolitis, Crohn's disease and sulpiride]. PMID- 4316828 TI - [Electrosplanchnography in mental anorexia and depression. 1st results]. PMID- 4316829 TI - [Electronystagmographic study of sulpiride in vestibular syndromes]. PMID- 4316830 TI - [Psychopathologic factors in Meniere's disease]. PMID- 4316831 TI - [Place of sulpiride in the treatment of gastroduodenal ulcer]. PMID- 4316832 TI - [Migraine and sulpiride]. PMID- 4316833 TI - [Value of sulpiride in pediatrics]. PMID- 4316834 TI - [Clinical trial of a new molecule, sulpiride, in psychiatric practice]. PMID- 4316835 TI - A good culture medium for endamoeba, balantidium and trichomonas. PMID- 4316836 TI - A study of fluorescent antibodies against Endamoeba histolytica). PMID- 4316837 TI - An ultrastructural study of spheroidal nuclear bodies found in gliomas. PMID- 4316838 TI - [Ultrastructural study of the sympathetic neuron in aged subjects. Acid phosphatase activity of pigments, abnormal mitochondria and presence of lamellar bodies]. PMID- 4316845 TI - Should phoniatry be an independent speciality or a subspeciality? PMID- 4316893 TI - Effects of increased cerebrospinal fluid pressure on the blood flow and on the energy metabolism of the brain. An experimental study. PMID- 4316894 TI - Pathogenesis of vesicular stomatitis virus infection in the infant hamster and mouse. PMID- 4316895 TI - Pathogenesis of vesicular stomatitis virus New Jersey infection in the adult hamster and mouse. PMID- 4316896 TI - [Gastrocolectomy for cancer. Apropos of 41 cases]. PMID- 4316897 TI - Renin levels in nephroblastoma (Wilms' tumour). Report of a renin secreting tumour. PMID- 4316898 TI - Islet-cell tumour causing hypoglycaemia in a newborn infant. PMID- 4316899 TI - [Data on the histo- and morphogensis of experimental tumors of the kidneys in animals]. PMID- 4316901 TI - Hypercalcaemic and hypermagnesaemic perfusion of the isolated autotransplanted adrenal glands in the conscious sheep. PMID- 4316900 TI - Specific analysis of the effect of ACTH on gastric mucus. PMID- 4316903 TI - [Problems of psychiatric hospitalization]. PMID- 4316902 TI - Collagenase activity and colonic anastomotic breakdown. PMID- 4316904 TI - Enzyme patterns during bone induction. PMID- 4316905 TI - Comparative aspects of bone and calcifying cartilage. PMID- 4316906 TI - Metabolism and biological activity of vitamin D. PMID- 4316907 TI - 25-hydroxycholecalciferol: effects in idiopathic vitamin D-resistant rickets. PMID- 4316908 TI - [Biological activity of 25-hydroxycholecalciferol in vitamin resitant osteomalacia]. PMID- 4316909 TI - Degradation processes in bone and cartilage. PMID- 4316910 TI - Enzymatic and other biochemical events accompanying bone resorption in tissue culture. PMID- 4316911 TI - Bone resorption and calcium homeostasis: one process or two? PMID- 4316912 TI - A parathyroid hormone-like action of dibutyryl cyclic adenosine-3', 5' monophosphate on the explanted embryonic mouse radius. PMID- 4316913 TI - [New data on comparative physiology of the sweat gland and nephron]. PMID- 4316914 TI - [Some features of tissue respiration and anaerobic glycolysis in the skin of persons of both sexes in eczema]. PMID- 4316915 TI - Electron spin resonance of gamma-irradiated single crystal of dihydrouracil. PMID- 4316916 TI - ESR study of single crystals of copper (II)-doped L-alanine. PMID- 4316918 TI - [Primary malignant hepatoma of the diaphragm. Description of a case and review of the literature]. PMID- 4316917 TI - [Interaction between neurogenic and renal factors of pathogenesis of hypertension]. PMID- 4316919 TI - Mapping human genes. PMID- 4316920 TI - Presence of EB virus nucleic acid homology in a "virus-free" line of Burkitt tumour cells. PMID- 4316921 TI - Rapid eye movements and remembering. PMID- 4316922 TI - [Re-epithelialization of colonic lesions in Crohn's disease. Anatomo-radiological study apropos of 5 cases of ileo-colitis]. PMID- 4316923 TI - [Neurogenic hypernatremia. A case observed during the course of a pinealoma]. PMID- 4316924 TI - [Pulmonary forms of infectious mononucleosis in children]. PMID- 4316925 TI - [Polydysplasia with areas of dermal hypoplasia]. PMID- 4316926 TI - [Study of the ventilatory compartments by the method of helium dilution]. PMID- 4316927 TI - [Polyglobulia]. PMID- 4316928 TI - [Laboratory in osteo-articular brucellosis. Classical methods, recent methods]. PMID- 4316929 TI - [Some peculiarities of corticosteroid action in rheumatism]. PMID- 4316930 TI - The neuromuscular junctions of a pulmonate mollusc. I. Ultrastructural study. PMID- 4316931 TI - [Orthophosphate saturation in phosphate-depleted cells of Candida utilis]. PMID- 4316932 TI - [Radioimmunologic assay of angiotension II]. PMID- 4316933 TI - Hypothesis: renin and angiotensin as a mechanism of diuretic-induced antidiuresis in diabetes insipidus. PMID- 4316934 TI - Type and course of the inflammatory cellular reaction in acute angiotensin hypertensive vascular disease in rats. PMID- 4316935 TI - Histochemical localization of various enzymes in human fatty liver caused by moderate alcohol consumption. PMID- 4316937 TI - [Mesodermal mixed tumor of the ovary. An anatomic study]. PMID- 4316936 TI - [Uptake and storage of catecholamines by adrenergic fibers of the central and peripheral nervous system. II. Preferential retention of noradrenaline]. PMID- 4316938 TI - [Granular cell myoblastoma. Description of a case with malignant evolution and final aspect of alveolar soft part sarcoma]. PMID- 4316939 TI - [Fractures and dislocations of the pelvic bones and their visceral complications]. PMID- 4316940 TI - [Infectious pathology. II. Viral pathology]. PMID- 4316941 TI - [Tracheo-bronchial surgery (study of 7 personal cases)]. PMID- 4316942 TI - [Role of angiotensin in the control of arterial pressure]. PMID- 4316943 TI - [Antagonists of antiviral action of interferon]. PMID- 4316944 TI - Renal and hepatic inactivation of angiotensin in rats: influence of sodium balance and renal artery compression. PMID- 4316945 TI - Alteration by xylocaine (lidocaine) and its derivatives of the time course of the end plate potential. AB - Xylocaine and its derivatives act specifically at the neuromuscular junction within the concentration range 0.05 to 2.0 mM. The charged form is the active form of the drugs. There is no correlation between "local anesthetic" activity and effect at the junction. Like d-tubocurarine, these drugs have little or no effect on quantum content, acetylcholinesterase activity, or the passive impedance of the muscle fiber. Yet they produce end plate potentials characterized by a brief, early component and a late, greatly prolonged component, as does procaine. Analysis of these changes in time course suggests that the drugs have little or no effect before receptors are activated by acetylcholine, but cause a decreased and often greatly prolonged response. Clear structure-activity relations indicate that the receptor to which the drugs bind to produce the prolonged response can be the receptor for acetylcholine. Comparison of the effects of the drugs on the end plate potential and on the response to iontophoretically applied acetylcholine also shows that the effects of Xylocaine depend on the time course of receptor activation and are quite different from the effects of d-tubocurarine. PMID- 4316946 TI - A kinetic model for the action of xylocaine on receptors for acetylcholine. AB - A kinetic scheme postulating the rapid formation of a partially active acetylcholine-receptor-drug complex from Xylocaine (or a derivative) and the active acetylcholine-receptor complex can account for the effects of Xylocaine and its derivatives at the neuromuscular junction. Transmembrane currents generated by an analogue computer programmed according to the scheme can exactly match end plate currents produced by nerve stimulation in the presence of the drugs. The scheme also accounts for the qualitatively different effects of the drugs on the end plate potential and on responses to iontophoretically applied acetylcholine. The analysis presented is consistent with very rapid reactions between acetylcholine and receptors, characterized by rate coefficients in the range 10(4) to 10(6) sec(-1). It is based on the hypothesis that the activation of receptors by acetylcholine changes the structure of the receptors and thus their affinity for Xylocaine. The analysis does not require pharmacological separability of sodium and potassium conductances during the end plate current. PMID- 4316947 TI - Analysis of spike electrogenesis of Eel electroplaques with phase plane and impedance measurements. AB - Eel electroplaques provide experimental conditions in which registration of phase plane trajectories (dV/dt vs. V) and impedance measurements with an AC Wheatstone bridge, in conjunction with spike electrogenesis describe quantitatively the ionic processes of the electrogenesis. Thus, these data employing as they do measurements of transients, permit an independent test of the validity of the assumptions which underlie the Hodgkin-Huxley equivalent circuit: independent ionic channels with fixed ionic batteries and exhibiting time-variant conductance changes with different kinetics for the different channels. The analysis accords with earlier findings on voltage-clamped electroplaques and this agreement confirms the validity of the equivalent circuit despite the fact that the current voltage characteristics of the axons and electroplaques differ profoundly. As for squid axons, the equivalent circuit of the electroplaques has four branches: a capacity and three ionic channels. One of the latter is an invariant leak channel (G(L)) of high conductance. A K channel (G(K)) is fully open at rest, but rapidly undergoes inactivation when the cell is depolarized by more than 40 mv. G(L) and G(K) have a common inside negative emf (E(K)). A Na channel (G(Na)) with an inside positive emf (E(Na)) is closed at rest, but opens transiently upon depolarization. PMID- 4316948 TI - [Enzymologic studies of the degradation and re-utilization of ribonucleic acids of Escherichia coli]. PMID- 4316949 TI - The perchloric acid catalyzed acetic anhydride enol acetylation of steroidal delta 4-3 ketones. PMID- 4316950 TI - [Corticotropic and melanophorotropic activities of pituitary extracts from 2 teleost fishes (carp and salmon). Anatomical dissociation of these 2 activities]. PMID- 4316951 TI - Protein-synthesizing structures associated with mitochondria. PMID- 4316952 TI - SV40 virus-induced tumour specific transplantation antigen in cultured mouse cells. PMID- 4316953 TI - Characteristics of a human diploid cell designated MRC-5. PMID- 4316954 TI - Powerful new inhibitor of murine leukaemia and sarcoma viruses. PMID- 4316955 TI - Effect of parathyroid extract on cyclic AMP content of embryonic mouse calvaria. PMID- 4316956 TI - Inactivation of angiotensin II analogues by isolated perfused rat liver and kidney. PMID- 4316957 TI - Induction of a nematode teratoma. PMID- 4316958 TI - Sub-surface structures in normal and malignant cells. PMID- 4316959 TI - Antiviral activity of double stranded RNA from a virus isolated from Aspergillus foetidus. PMID- 4316960 TI - Effect of collagen and acid polysaccharides on the growth of BHK-21 cells in semi solid media. PMID- 4316961 TI - Herpetic infection in adults. Acute gingivostomatitis and associated traumatic herpes. PMID- 4316962 TI - [Aero-fungal inventory of the environment of 55 asthmatic patients. Study of the correlations with allergologic report]. PMID- 4316963 TI - [Brucellosis caused by Brucella abortus in humans in France. A survey at Indre-et Loire]. PMID- 4316964 TI - [Periodic disease and endocrine disorders]. PMID- 4316965 TI - [Treatment of periodic disease with immuno-depressive agents]. PMID- 4316966 TI - [The value in pathology of red cell magnesium determination]. PMID- 4316967 TI - [Management of antibiotic therapy in chronic bronchitis]. PMID- 4316968 TI - [Serologic study of 689 strains of Staphylococcus aureus isolated in Tours]. PMID- 4316969 TI - Selective effect of quaternary ammonium salts on the activity of arylaminopeptidases of the dental pulp, and on trypsin, chymotrypsin and leucine aminopeptidase. PMID- 4316970 TI - Inhibitory action of prostaglandins E1 and E2 on the neuromuscular transmission in the guinea pig vas deferens. PMID- 4316971 TI - The role of cyclic 3', 5'-adenosine monophosphate in thyroid function. PMID- 4316973 TI - [Primary hepatic carcinoma]. PMID- 4316972 TI - Oxidation of sulfur compounds and electron transport in Thiobacillus denitrificans. PMID- 4316974 TI - Induction of carcinomas in the nasal cavity of rats by dioxane. AB - Six out of 120 rats fed dioxane in drinking water at levels of 0.75, 1.0, 1.4 or 1.8% developed carcinomas in the nasal cavity. Spontaneous tumors at this tissue localization have not been reported to occur in laboratory animals. The carcinomas were pre-eminently of epidermoid type with few adenocarcinomatous areas and epithelial papillomas. Four rats with carcinoma of the nasal cavity had hepatocellular carcinoma in addition. PMID- 4316975 TI - Early ("prophylactic") oophorectomy and adrenalectomy in carcinoma of the breast: a ten-year follow-up. AB - Early "prophylactic" oophorectomy and adrenalectomy has been performed on 12 patients with carcinoma of the breast. The patients selected were considered to have a very bad prognosis on account of axillary node involvement associated with internal mammary chain deposits (9 patients), supraclavicular nodes (2 patients) and a parasternal mass (1 patient). Five patients had evidence of spread beyond the primary lymph drainage area (axillary and internal mammary nodes), and all had died within 4 years. In 7 patients the disease was confined to the primary lymph drainage area and 4 lived for more than 10 years, 3 being alive and well at 11 to 12 years. This is a higher proportion than in a control series but does not quite reach the level of statistical significance. In the 7 patients with disease confined to the axillary and internal mammary nodes prognosis was not apparently related to malignancy determined histologically, but did have an association with the extent of invasion of the axillary nodes. Urinary oestrogen estimations performed in 4 patients did not give any evidence that outcome was related to persistence of oestrogen production. Details of the patients' management and replacement therapy are given and from prolonged personal follow-up of these patients it is concluded that women who have undergone oophorectomy and adrenalectomy are able to lead full and active lives. PMID- 4316977 TI - Staging in relation to treatment of nephroblastoma with actinomycin D. PMID- 4316976 TI - Primary carcinoma of the liver in Ethiopia. A study of 38 cases proved at post mortem examination. PMID- 4316978 TI - Congenital Wilms' tumour: case report. PMID- 4316979 TI - Growth studies of calcium oxalate in the presence of various compounds and ions. II. PMID- 4316980 TI - Treatment of the nephrotic syndrome. PMID- 4316981 TI - Azathioprine in pemphigus vulgaris. PMID- 4316982 TI - Electron microscopic observations on the development of variola virus in chick embryo chorioallantoic membrane cells. PMID- 4316983 TI - [Study of respiratory chain of mitochondria of yeasts Candida lipolytica cultivated on hexadecane]. PMID- 4316984 TI - Tumors of peripheral nerve origin: benign and malignant solitary schwannomas. PMID- 4316985 TI - Viral etiology of cancer, leukemia and allied diseases. PMID- 4316986 TI - Carcinoma of the colon and antecedent epithelium. Report of a symposium. PMID- 4316987 TI - A saturation assay for cyclic adenosine monophosphate. PMID- 4316988 TI - [Histochemical studies of phosphatases in the process of healing of damaged dental pulp during conservative treatment]. PMID- 4316989 TI - [The effect of some filling materials and metals used in dentistry on the salivary acid phosphatase activity]. PMID- 4316990 TI - Serum ATP-ase and AMP-ase in liver cirrhosis and in hepatic coma. PMID- 4316991 TI - Serum glucose-6-phosphatase activity in acute hepatitis. PMID- 4316992 TI - Permeability of amphibian lens membranes to water. PMID- 4316993 TI - Lipids of ocular tissues. 3. The phospholipids of mature bovine iris. PMID- 4316994 TI - A histochemical study of oxidative enzymes in rat retina damaged by visible light. PMID- 4316995 TI - Chorioadenoma destruens. Case report. PMID- 4316996 TI - Gram negative septic shock. Experimental and clinical studies. PMID- 4316997 TI - Nucleoside phosphorothioates. PMID- 4316998 TI - Location of L-iditol: NAD oxidoreductase (D-sorbital tetrazolium reductase or ketose-reductase) in the genital tract of the bull. PMID- 4316999 TI - [Conservative treatment of ulcerative colitis and its limitation7]. PMID- 4317000 TI - Hepatocellular carcinoma with metastasis to gingival mucosa: report of case. PMID- 4317001 TI - [Sensitivity of cell lines stored in a frozen state to polioviruses type 1, 2 and 3]. PMID- 4317002 TI - Prevention of catheter-induced urinary tract infections. PMID- 4317003 TI - Use of diuretics in liver disease with ascites. PMID- 4317004 TI - [Enzyme deviation in cancer cells]. PMID- 4317005 TI - [Human cancer viruses]. PMID- 4317006 TI - [Mechanism of viral carcinogenesis]. PMID- 4317007 TI - [Naturally occurring chemical carcinogens]. PMID- 4317008 TI - [The effect of red streptomyces pigments on multiplication of adeno- and polioviruses in HeLa cells by means of fluorescence photometry]. PMID- 4317009 TI - [A medium for the differentiation of some pathogenic clostridia]. PMID- 4317010 TI - Cytomegaloviremia as a cause of delayed posttransfusion fever. PMID- 4317011 TI - [A case of synovialoma or malignant hemangioendothelioma of the wrist]. PMID- 4317012 TI - [Interference and production of interferon in chicken cells infected with Adenovirus 4, 7, 8 and 18]. PMID- 4317013 TI - [New trials of purity of phenothiazine by thin-layer chromatography]. PMID- 4317015 TI - Herpesvirus infection in burned patients. PMID- 4317014 TI - An investigation of radioactive yttrium (90Y) for the treatment of chronic knee effusions. PMID- 4317016 TI - [Identification by electron microscope of corticotropic cells in intact rats; results of adrenalectomy with and without treatment with dexamethasone]. PMID- 4317017 TI - Soluble beta-NADH oxidase system in the young root of the broad bean, Vicia faba. II. Participation of p-benzoquinone. PMID- 4317018 TI - On the collagenolytic activity of the mammalian pancreas. PMID- 4317019 TI - Some factors influencing the determination of phosphatase activity in native soils and in soils sterilized by irradiation. PMID- 4317020 TI - Succinate dehydrogenase and cytochrome oxidase in Derxia gummosa. PMID- 4317021 TI - [Activator effect of calcium on synthetic substrates of aminopeptidase which are analogs of angiotensin]. PMID- 4317022 TI - The purification and properties of mouse liver deoxyribonuclease II. PMID- 4317023 TI - Studies on serum phosphatases. V. Nonspecific human alkaline phosphatase and FDPase in normal and pathological conditions. PMID- 4317024 TI - Rat brain enzyme activities in Noble-Collip drum shock after sedation with chlorethoxybutamoxane. PMID- 4317025 TI - [Aspects of oculomotor physiopathology]. PMID- 4317026 TI - [Changes in urinary 17-ketosteroid level in surgical stress]. PMID- 4317027 TI - [Gas liquid chromatography analysis of urinary neutral steroid fractions in normal persons and patients with various diseases]. PMID- 4317029 TI - [The course and results of treatment of pulmonary tuberculosis as a function of the dosage of Pyrazinamide]. PMID- 4317028 TI - [Release of catecholamines from the adrenal medullary granules]. PMID- 4317030 TI - [Suspension culture of rat liver cells. I. Standardization of the method]. PMID- 4317031 TI - [Glucose-sensing cell (gastric type)]. PMID- 4317032 TI - [Pharmacology of diuretics--diuresis and reactions in vivo]. PMID- 4317033 TI - [Diagnosis and management of Cushing' syndrome based on our 28 cases, with special reference to combined therapy of 60Co irradiation of the hypothalamus and reserpine]. PMID- 4317034 TI - [Pathobiochemistry of tumor-bearing animals ii. Clinical application of tumor bearing animals. Free amino acids and ESR]. PMID- 4317035 TI - [Enzymes of the aortic wall and their metabolic characteristics]. PMID- 4317036 TI - Isolation of variola virus in a continuous monkey kidney cell line culture and some properties of the isolated virus. PMID- 4317037 TI - Research on dengue in tissue culture. IV. Serologic responses of human beings to combined inoculations of attenuated, tissue-cultured type I dengue virus and yellow fever vaccine. PMID- 4317038 TI - Endemic goiter in Greece: effects of iodized oil injection. PMID- 4317040 TI - [Metabolism and regulation of aldosterone secretion]. PMID- 4317039 TI - Characterization of the products of DNA-directed DNA polymerases in oncogenic RNA viruses. PMID- 4317041 TI - Transformation of labeled cholesterol, 20alpha-hydroxycholesterol, dried preparations from guinea pigs, cattle and man. II. Kinetic studies. PMID- 4317042 TI - [Ovarian thecoma in a 13-year-old girl]. PMID- 4317043 TI - [The prognostic value of the Kaplan-Silah angiotensin test]. PMID- 4317044 TI - [Hepatoma in the autopsy material of the Zurcher Pathologische Institute during the years 1901-1966 (86,549 autopsies). With a method of evaluating epidemiologic relationships on the basis of autopsy statistics]. PMID- 4317045 TI - Mesenteric adenitis in childhood simulating intussusception. PMID- 4317046 TI - Pre-eclampsia and related complications of pregnancy. PMID- 4317047 TI - Glomus tumors of the stomach. PMID- 4317048 TI - Renal regulation of sodium excretion. PMID- 4317050 TI - [Change in the composition of the microbial mass of type A Cl. perfringens during the growth of cultures]. PMID- 4317049 TI - [Myocardial contractility: biochemical bases and mechanism of action of drugs with positive inotropic effect]. PMID- 4317051 TI - Late brain recovery processes after drug overdose. AB - Though recovery of consciousness after drug overdose may occur within a day or two, the drug itself may not finally leave the brain for another one to three weeks, and at this late time a withdrawal syndrome can occur, with insomnia, restlessness, raised paradoxical (R.E.M.) sleep, epileptic phenomena, and even delirium. It is proposed that a high degree of drug-tolerance and dependence can be rapidly acquired after overdose.Abnormal sleep features of 10 patients resolved only slowly over a period of up to two months after overdose. The data support the view that R.E.M. sleep is concerned with processes of brain repair. PMID- 4317052 TI - Interaction of diazepam with the muscle-relaxant drugs. AB - Diazepam has been found to increase the duration of the neuromuscular block produced by gallamine and to reduce that produced by succinylcholine. Preliminary studies suggest that the action is at the presynaptic site. PMID- 4317053 TI - Corticosteroids and pituitary-adrenal function. PMID- 4317054 TI - Crohn's disease and pregnancy. PMID- 4317055 TI - Receptors for angiotensin I and II. PMID- 4317056 TI - Conversion of angiotensin. I. Measurement of plasma angiotensin I converting enzyme activity. PMID- 4317057 TI - Communication in cell communities. PMID- 4317059 TI - [2 cases of mixed ectopic salivary tumors]. PMID- 4317058 TI - [Neonatal mortality. Description of clinical cases of rare occurrence]. PMID- 4317060 TI - Parent guidance groups: is this therapy? PMID- 4317061 TI - Institutional and community involvement in providing work for the elderly. PMID- 4317062 TI - Problems in leader initiated change studies. PMID- 4317063 TI - An account of a nurse's role and functions in an alcoholic treatment program. PMID- 4317064 TI - Excerpts from a discussion of psychiatric nursing. PMID- 4317065 TI - Psychological aspects of abortion in Czechoslovakia. PMID- 4317066 TI - Psychiatric drugs and trends. Review of the phenothiazines. I. PMID- 4317067 TI - Geriatrics. PMID- 4317068 TI - The third hand: a theory of support. PMID- 4317069 TI - Selection of morphologically normal cell lines from polyoma-transformed BHK21/13 hamster fibroblasts. AB - A selective method was devised for the isolation of "revertants" from polyoma transformed sublines derived from BHK21/13 Syrian hamster fibroblasts. A hybrid, polyploid subline was obtained by growing together, in mixed culture in the presence of aminopterin, two variant BHK21/13 sublines lacking either inosinic acid pyrophosphorylase or thymidine kinase. Whereas these variant sublines were resistant to 6-thioguanine or to 5-bromodeoxyuridine, the hybrid had regained sensitivity to both analogues. By plating a polyoma-transformed subline derived from this hybrid in the presence of 6-thioguanine, resistant clones were obtained with a frequency of about 10(-4). All of these surviving clones had a reduced chromosome complement and some of them had regained a normal phenotype. PMID- 4317071 TI - [Radiotherapy of malignant tumors in children, with special reference to the sensitizing effect of actinomycin D]. PMID- 4317070 TI - The treatment of pyoderma in children. PMID- 4317073 TI - The human pancreatic islet cells and their tumors. I. The normal pancreatic islets. PMID- 4317072 TI - [Neosporin as premedication in eye surgery]. PMID- 4317074 TI - Luteoma of pregnancy. Report of a case. PMID- 4317075 TI - Total cytochrome-oxidase activity of the brown fat and its thermogenetic significance. PMID- 4317076 TI - [Etiology of acute respiratory diseases in military personnel]. PMID- 4317077 TI - Virus-specific, labile, nonvirion antigen in herpesvirus-infected cells. AB - The search for a specific, serologically identifiable nonvirion antigen (i.e., not a structural component of the virus) in cells infected with herpes simplex virus (HSV) was undertaken as an approach to the problem of the possible role of this virus in certain types of human cancer.Synthesis of structural components of HSV could not be prevented by a variety of inhibitors of DNA synthesis or by incubation at certain high or low temperatures, and it was, therefore, necessary to devise methods for the detection of nonvirion antigen in the presence of virion antigens. This was achieved by means of specially prepared and absorbed antisera only after the unusual lability and sedimentability of the nonvirion component became apparent. The special sera were derived from guinea pigs hyperimmunized with uncentrifuged extracts of guinea pig kidney culture cells freshly prepared three hours after infection with 20 to 30 plaque-forming units (PFU) of HSV per cell. It was possible to remove the neutralizing (N) antibodies for live virus and the complement-fixing (CF) antibodies for the sedimentable and soluble virion antigens, without loss of CF antibodies for nonvirion antigen, by absorption of these sera with uncentrifuged, HSV infected cell extracts that had been stored at +4 degrees or -66 degrees C, or both, for a sufficiently long time to permit the disappearance of the labile, nonvirion components. Human, rabbit, and guinea pig sera obtained after infection or after "ordinary" hyperimmunization had no CF antibodies for the labile, nonvirion antigen after comparable absorption. The nonvirion antigen detected in this manner is specific not only for HSV but also for the type (or strain?) of HSV, since infection of guinea pig kidney culture cells with vaccinia virus or type 2 (genital) HSV yielded no antigen detectable with the absorbed serum prepared against the type 1 HSV strain; the type 2 HSV produced large amounts of type 1 HSV virion antigen under these conditions, and the vaccinia virus large amounts of antigen reactive with ordinary rabbit antivaccinial serum. The nonvirion antigen was formed at maximum concentration early (3 hr) after high multiplicity HSV infection in guinea pig cells but late in the infectious process (12-24 hr) in rabbit or HEp 2 cells. The supernatant fluid had only 50 per cent of the activity after centrifugation at 1500 g for ten minutes and none after a further centrifugation at 33,360 g for one hour. Storage at +4 degrees C for eight to nine days led to complete loss of activity of the nonvirion antigen but no loss of activity of the various sedimentable and soluble virion antigens. At -66 degrees C or lower temperatures 50 per cent of the activity was lost in seven days and further loss occurred at different rates in extracts of guinea pig, rabbit and HEp 2 cells. PMID- 4317078 TI - [Anterior pituitary function tests]. PMID- 4317079 TI - [Adrenocortical insufficiency due to pituitary insufficiency]. PMID- 4317080 TI - [Catecholamines in adrenocortical insufficiency]. PMID- 4317081 TI - [Reversible disorders of hepatic function in cancer of the kidney]. PMID- 4317082 TI - [Statistical data on the functioning of the psychiatric department of the International Hospital of the University of Paris. Epidemiologic considerations on foreign patients]. PMID- 4317083 TI - [Pharmacology of adrenergic-blocking agents]. PMID- 4317084 TI - Intravascular coagulation in systemic amyloidosis. PMID- 4317085 TI - [What factors influence the cure rate in ovarian carcinoma?]. PMID- 4317086 TI - The function of the pituitary gland and the adrenal cortex during treatment with glucocorticoids. PMID- 4317087 TI - [Progressive polioencephalopathy with neurofibrillary degeneration]. PMID- 4317088 TI - Electron-histochemical studies on the lysosome system in ascites hepatoma AH 13 cells. PMID- 4317089 TI - Generalized cytomegalic inclusion disease in an adult, with primary systemic involvement of lymph nodes--a case report. PMID- 4317090 TI - [Thin layer silicagel chromatography of antibiotics related to azalomycin F]. PMID- 4317091 TI - [Comparative study of the reaction of tissue cells on the effect of some antibiotics and their combination]. PMID- 4317092 TI - Correlation between humification and the oxidase activity of the causative micro organisms. PMID- 4317093 TI - The oxidation and reduction of pyridine nucleotides by Rhodopseudomonas spheroides and Chlorobium thiosulfatophilum. PMID- 4317094 TI - Hypophosphatasia associated with calcium pyrophosphate dihydrate deposits in cartilage. Report of a case. PMID- 4317095 TI - Diazepam and neuromuscular transmission. PMID- 4317097 TI - [Pituitary-adrenal function test by menas of metyrapone and ACTH in nephrotic patients under protracted corticosteroid treatment]. PMID- 4317098 TI - [Carcinoma basocellulare cylindromatosum (so-called cylindroma) in the salivary glands and paranasal sinuses]. PMID- 4317096 TI - Malignant hyperthermia: aetiology unknown. PMID- 4317099 TI - The rapid separation of aflatoxins on silica gel coated glass cylinders. PMID- 4317100 TI - Determination of aflatoxins in peanut and cottonseed soapstocks. PMID- 4317101 TI - Evidence for a second chemotactic system in the cellular slime mold, Dictyostelium discoideum. AB - An unknown substance found in bacteria (Escherichia coli) is especially effective in attracting the vegetative amoebae of the cellular slime mold, Dictyostelium discoideum. However, the aggregating amoebae are not attracted to it at all. On the other hand, the vegetative amoebae show very little chemotactic response to cyclic adenosine monophosphate (cyclic AMP), whereas the aggregating amoebae are exceptionally responsive to it. It is suggested that the new factor may be used in food seeking, whereas cyclic AMP, the chemotactic substance responsible for aggregation, is the acrasin of this species. The important point is that the amoebae are differentially stage-specific in their responses to these two chemotactic agents. PMID- 4317102 TI - Comparison of lysyl-transfer ribonucleic acid species from vegetative cells and spores of Bacillus subtilis by methylated albumin-kieselguhr and reversed-phase chromatography. AB - Lysyl-transfer ribonucleic acid (tRNA) species from a spore-forming strain of Bacillus subtilis (168 trp2(-)) and an early blocked asporogenous mutant (spoA 12) were compared on reversed-phase and methylated albumin-kieselguhr columns. Lysyl-tRNA species from spores and the asporogenous mutant in stationary phase both exhibited altered chromatographic profiles compared to that of log-phase cells. The major peak in spore lysyl-tRNA species eluted later than that characteristic of vegetative cells, whereas the major peak of the lysyl-tRNA species from the asporogenous mutant in stationary phase eluted earlier. Although the early eluting lysyl-tRNA species was observable on methylated albumin columns, the late eluting peak was not detectable by that column technique. By using a shallower gradient on an RPC-2 column, the resolution of all lysyl-tRNA species increased. Several subspecies were revealed. The chromatographic comparisons clearly show that both the spore-forming strain and the asporogenous mutant undergo relative increases in different lysyl-tRNA species when grown to late stationary phase. No new species seem to be involved but rather altered amounts of minor species existing in log-phase cells. The experiments also demonstrate the usefulness of reversed-phase columns for such comparisons. PMID- 4317103 TI - Correlation of ESR and optical spectra from five x-irradiated amino acids. PMID- 4317104 TI - EPR study of radiation damage of deuterated single crystal of thymidine. PMID- 4317105 TI - Electronic structure of thymine. PMID- 4317106 TI - In vitro method for safety testing of foot-and-mouth disease vaccines. AB - The susceptibility of the tissue culture system to small amounts of residual live virus was not influenced by the inactivated antigen present. The depth of inoculum over the cell sheet did not affect results. Negative cultures frequently gave positive first (but not second or later) sub-cultures.Baby hamster kidney cells were always more sensitive than cattle tongues to infection with any of the strains used.Confidence in the safety test depends on the number of vaccination doses used; the tissue culture test can be made much more reliable than the cattle test because it is not limited to the 15 ml. of inoculum that restricts the cattle test. PMID- 4317108 TI - [Studies on determination of poliovirus neutralizing antibodies by air dried filter paper disc method]. PMID- 4317107 TI - An adhesive surface sampling technique for airborne viruses. AB - A mixture of sucrose, glycerol and bovine serum albumin produces a stable coating in a Petri dish which remains adhesive for up to an hour when exposed in a slit sampler. Virus aerosols can be collected on this surface followed by the direct addition of cell cultures to demonstrate the presence of viable virus. The technique is applicable to the Andersen sampler. A modified version of this sampler has been produced with the same particle collection efficiency as the standard Andersen sampler. The plaque counts obtained by the adhesive surface sampling technique are believed to give an indication of the number of particles collected bearing viable virus. PMID- 4317109 TI - Free-radical intermediates in the reaction of the hydroxyl radical with amino acid derivatives and related compounds. PMID- 4317111 TI - Inhibition of synchronized cellular deoxyribonucleic acid synthesis during Newcastle disease virus, mengovirus, or reovirus infection. AB - Cultures of L cells were synchronized with respect to deoxyribonucleic acid (DNA) synthesis with thymidine and 5-fluoro-2'-deoxyuridine (FUdR) and infected with Newcastle disease virus (NDV), mengovirus, or reovirus 3. Inhibition of incorporation of (3)H-cytidine into the DNA of synchronized cells is partially inhibited 2 hr after infection with NDV or mengovirus and nearly completely suppressed 4 hr after infection. With NDV and mengovirus, no evidence was obtained of differences in sensitivity of cells during early S phase as compared to later stages in DNA synthesis. When cells were infected with reovirus at the time of release from FUdR block, inhibition of cellular DNA synthesis was evident at 2 to 3 hr, and it was complete at 4 to 5 hr after infection. However, when cells were infected several hours prerelease, synthesis of DNA occurred in early S phase in spite of the fact that the cells had been infected for up to 6 hr. The results indicate that DNA synthesis in early S phase is relatively insensitive to the inhibitory function of reovirus. Colorimetric determinations (diphenylamine reaction) of the amounts of DNA produced in synchronized cells have substantiated the inhibition of DNA synthesis observed by isotope incorporation techniques. PMID- 4317110 TI - Ribonucleic acid polymerase induced in cells infected with Sendai virus. AB - A ribonucleic acid (RNA)-dependent RNA polymerase was induced in chick embryo fibroblast cells after infection with Sendai virus (parainfluenza 1 virus). The enzyme was associated with the microsomal fraction of infected cells and reached maximum detectable activity at 18 hr after virus infection. The activity of the enzyme in vitro was dependent on the presence of added magnesium ions and all four nucleoside triphosphates and was not inhibited by actinomycin D. The RNA synthesized by the enzyme in vitro was sensitive to ribonuclease and consisted of a complex mixture of RNA species including 34S, 24S, and 18S components. Similar RNA components were detected in the microsomal fraction of Sendai virus-infected cells by labeling with (3)H-uridine from 17 to 18 hr postinfection in the presence of actinomycin D. Of the RNA synthesized by Sendai virus-induced RNA polymerase in vitro, 98% became insensitive to ribonuclease after annealing with RNA extracted from purified Sendai virus particles. PMID- 4317112 TI - Human-mouse hybrid cell lines and susceptibility to poliovirus. I. Conversion from polio sensitivity to polio resistance accompanying loss of human gene dependent polio receptors. AB - A number of human-mouse somatic hybrid cell lines have been prepared, containing from 3 to 12 human biarmed chromosomes. These lines were susceptible to poliovirus type 1, producing viral yields comparable to those of the human parental cells. A small proportion of the cells of these lines survived the polio infection, and their progeny were solidly resistant to reinfection with the virus. Both sensitive and resistant hybrids produced virus following infection with viral ribonucleic acid, indicating that the cytoplasm of the resistant hybrids was able to support viral multiplication. Viral adsorption studies carried out at 4 C showed that the resistant sublines had negligible ability to adsorb the virus. It was concluded that the hybrid cells became resistant to polio through loss of the human chromosome bearing the gene for the receptor substance. PMID- 4317113 TI - Human-mouse hybrid cell lines and susceptibility to polio virus. II. Polio sensitivity and the chromosome constitution of the hybrids. AB - A number of human-mouse hybrid cell lines with partial human chromosome complements were sensitive to poliovirus because the cells contained the viral receptor substance of human origin. Infection of the lines with one type of poliovirus regularly led to the survival of a few cells, whose progeny were found to be resistant to all types of poliovirus. Comparison of the chromosomes of sensitive hybrids and their resistant sublines showed no consistent difference in the number of biarmed human chromosomes of any group. The number of acrocentrics was always lower in the resistant hybrids than in the corresponding sensitive lines. It is suggested that the human chromosome bearing the polio receptor gene is an acrocentric. PMID- 4317115 TI - [Longitudinal dynamic study of plasma insulin in Langerhans adenoma]. PMID- 4317114 TI - Deoxyribonucleic acid replication in simian virus 40-infected cells. 3. Comparison of simian virus 40 lytic infection in three different monkey kidney cell lines. AB - A comparative study of simian virus 40 (SV40) lytic infection in three different monkey cell lines is described. The results demonstrate that viral deoxyribonucleic acid (DNA) synthesis and infectious virus production begin some 10 to 20 hr earlier in CV-1 cells and primary African green monkey kidney (AGMK) cells than in BSC-1 cells. Induction of cellular DNA synthesis by SV40 was observed in CV-1 and AGMK cells but not with BSC-1 cells. Excision of large molecular weight cellular DNA to smaller fragments was easily detectable late in infection of AGMK cells. Little or no excision was observed at comparable times after infection of CV-1 and BSC-1 cells. The different kinds of responses of these three monkey cell lines during SV40 lytic infection suggest the involvement of cellular functions in the virus-directed induction of cellular DNA synthesis and the excision of this DNA from the genome. PMID- 4317116 TI - [Grant angiofibroma of the dorsum]. PMID- 4317117 TI - X-ray diagnosis of mixed forms of the stomach cancer. PMID- 4317118 TI - [Chemodectoma of the stomach]. PMID- 4317119 TI - Antagonism between perazine and flavine on the NAD-kinases of rat brain and liver. PMID- 4317120 TI - Nicotinic drugs and postganglionic sympathetic transmission. PMID- 4317121 TI - Evidence for an etiologic role of adenoviral infection in pertussis syndrome. PMID- 4317122 TI - Whooping cough - viral or bacterial disease? PMID- 4317124 TI - Anamnestic response to Leptospira canicola and infectious canine hepatitis antigens in beagles exposed to 90Sr by inhalation or intravenous injection. PMID- 4317123 TI - [Excretion of urinary steroids before and after administration of beta 1-24 corticotropin in patients with cancer of the breast]. PMID- 4317125 TI - Free-radical production by heavy ions at 77 degrees-K and its relation to the thermal spike theory. PMID- 4317126 TI - Lysosomal and some other hydrolytic enzyme activities in the whole liver and isolated hepatocyte suspension. PMID- 4317127 TI - Endocrine patterns in the African. Clinico-biochemical assessment. PMID- 4317128 TI - Cirrhosis and primary liver-cell carcinoma in Uganda. PMID- 4317129 TI - Serological survey on viral antibodies in Iran. PMID- 4317130 TI - [Enteritis and enterocolitis in viral respiratory infections]. PMID- 4317132 TI - [The PAS-substance in the motor end plate and myotendinous junction]. PMID- 4317131 TI - [Use of interferon for prevention of hospital infection in departments for respiratory diseases]. PMID- 4317133 TI - On the submicroscopic structure of nuclear inclusions in cytomegaly. A polarisation optical analysis. PMID- 4317134 TI - The chemocytological investigation on the goat adrenal medulla. PMID- 4317136 TI - Glucose-6-phosphate hydrolysing activity in the cerebellum of the mouse, rat, hamster and marmoset. PMID- 4317135 TI - [Enzyme histochemical studies on the development of neuroglia in the human brain]. PMID- 4317137 TI - Endometrial carcinoma in patients with bilateral oophorectomy or irradiation castration. PMID- 4317139 TI - [Tissue collagenase during cicatrization]. PMID- 4317140 TI - [Free radical state during respiratory processes and phosphorylation in mitochondria]. PMID- 4317138 TI - Cardiovascular alterations in toxemia. PMID- 4317141 TI - [Analysis of ESR spectra of wheat seeds irradiated during anoxia]. PMID- 4317142 TI - [Formation of free radicals in aliphatic amino acids and peptides under conditions of photosensitization by dyes]. PMID- 4317143 TI - [Localization of the action of digestive enzymes in the intestine]. PMID- 4317144 TI - [Intersegmentary routes of the visceralmotor reflexes of the spinal cord]. PMID- 4317145 TI - [Time dynamics of changes in specific and relative specific radioactivity of phosphorus of individual fractions of rat brain phospholipids]. PMID- 4317146 TI - The Gilstone skull. PMID- 4317147 TI - [3 cases of pluriorificial ectodermosis with rhinopharyngitis, bronchitis, conjunctivitis, adenomegaly and significant serologic ascent for APC virus]. PMID- 4317148 TI - [Phosphatase activity of thorium and zirconium ions on lecithin and other metabolites as substrate]. PMID- 4317149 TI - Studies on the proline oxidase complex. PMID- 4317150 TI - Oxidation and enzymatic reduction of a lipid fraction acting on arterial pressure. PMID- 4317151 TI - Human placental alkaline phosphatase; a sialoprotein. PMID- 4317152 TI - The kinetics of the reactions catalyzed by D-glyceraldehyde-3-phosphate dehydrogenase. 3. The pH dependence of apparent michaelis constants and maximum velocity. PMID- 4317153 TI - Fly control, chronic toxicity, and residues from feeding propyl thiopyrophosphate to laying hens. PMID- 4317154 TI - [A case of Wilms tumor in an adult]. PMID- 4317155 TI - Primary cancer of liver. PMID- 4317156 TI - [25-hydroxycholecalciferol. Effect of a single dose in normal children]. PMID- 4317157 TI - Colloid carcinoma in the ano-rectal region. PMID- 4317158 TI - Subacute neurologic manifestations of hypoglycemia: a case report. PMID- 4317159 TI - [Content of certain trace elements in the blood of patients with Lever's bullous pemphigoid, Sneddon-Wilkinson subcorneal pustulosis and Hailey-Hailey benign familial pemphigus]. PMID- 4317161 TI - Bats as possible maintenance hosts for vesicular stomatitis virus. PMID- 4317160 TI - [Origin. Pollution of the general atmosphere in working places]. PMID- 4317162 TI - Methisazone and monkey pox virus: studies in cell cultures, chick embryos, mice and monkeys. PMID- 4317163 TI - The skin and the prostaglandins. PMID- 4317164 TI - Multiple glomus tumors (cavernous type). PMID- 4317165 TI - Metastatic carcinoma of the scalp. PMID- 4317166 TI - Glucose and baroreceptor function. Effects of oral administration of glucose on baroreceptor function in cerebrovascular disease and in other disorders with baroreceptor reflex block. PMID- 4317167 TI - A method for determination of renin activity in dog's plasma and renal tissue. PMID- 4317168 TI - Interaction of yeast aldehyde dehydrogenase with analogues of nicotinamide adenine dinucleotide. PMID- 4317170 TI - Possibility of anion formation in irradiated frozen solutions of nucleic acid bases. PMID- 4317169 TI - Glucocorticoids and the gastrointestinal tract: current status. PMID- 4317171 TI - Spin-quenching by oxygen of a radiosensitizing nitroxide free radical in aqueous solution. PMID- 4317173 TI - Quantitative recovery of sugars from silica gel thin layers. PMID- 4317172 TI - Separation of polar lipids by column chromatography on hydroxylapatite. PMID- 4317174 TI - [Analysis of plant glyco- and phospholipids and their fatty acids. I. A new thin layer chromatographic method for the separation of plant lipids and quantitative determination of their fatty acid composition]. PMID- 4317175 TI - Thin-layer chromatography and ultraviolet spectrophotometry of mixtures of sulfonamides. Practical applications. PMID- 4317176 TI - Thin-layer chromatography of substituted methyl beta-maltosides. PMID- 4317177 TI - A method for the one-dimensional thin-layer chromatographic separation of serum phospholipids. PMID- 4317178 TI - [Micromethod for the analysis of adenine nucleotides]. PMID- 4317179 TI - The preparation of virus-infected cells for use in immunofluorescence techniques. AB - This paper describes the preparation of virus-infected cells for the detection of serum antibodies by the use of immunofluorescence techniques. The variations in virus growth in cells in relation to the length of incubation of cell monolayers and polio virus using two different fluorescein isothiocynate conjugates are discussed. It is shown that there is a critical time after virus infection when a definite positive immunofluorescent reaction is given. Furthermore, a method is described enabling the clinical pathologist to prepare infected cells with the use of an automatic tube inoculator at any time during 24 hours. PMID- 4317180 TI - Relationship of staphylococcal toxins and enzymes with serological and phage types. AB - A study has been made of 523 strains of staphylococci on the basis of biological properties, phage typing, and serology. The value of serology in the identification of pathogenic staphylococci has been assessed. PMID- 4317181 TI - The effect of perchlorate on the localization of 99mTc-pertechnetate in a mouse brain sarcoma. PMID- 4317182 TI - Visualization of tumors in humans using 67Ga-citrate and the Anger whole-body scanner, scintillation camera and tomographic scanner. PMID- 4317183 TI - Screening test for gonorrhea in male suspects. PMID- 4317184 TI - Parkinsonism. PMID- 4317185 TI - A comparison of the effects of Trasicor (oxprenolol) and Inderal (propranolol) on left ventricular myocardial function. PMID- 4317186 TI - Immunology of trophoblastic tumours. PMID- 4317187 TI - Sarcomas of the breast. PMID- 4317188 TI - Scintigraphy and angiography in primary tumours of bones and joints. (Correlations, limits and possibilities). PMID- 4317189 TI - General principles of radiation treatment of tumour of the central nervous system. PMID- 4317190 TI - Radiation treatment results in brain tumours. PMID- 4317191 TI - Newer trends in corticosteroid therapy. PMID- 4317192 TI - Leiomyoblastoma--an unusual tumor of stomach. PMID- 4317193 TI - [Biochemical and clinical features of pyrophosphate metabolism. IV. Inhibition of human renal pyrophosphatase by inorganic orthophosphate in healthy persons and patients with calculi]. PMID- 4317194 TI - Cellular proliferation and carcinogenesis. ANL-7635. PMID- 4317195 TI - Metabolic and morphologic studies of hepatocarcinogenesis in the rat. ANL-7635. PMID- 4317196 TI - Electron spin resonance studies of gamma-ray irradiated dinucleotides at 77 degrees-K. ANL-7635. PMID- 4317197 TI - [Overcoming of species cellular resistance by tumor viruses]. PMID- 4317198 TI - [Determining Clostridium perfringens by the fluorescent antibody technic]. PMID- 4317199 TI - [A simplified method for determining Clostridium perfringens]. PMID- 4317200 TI - [Effect of hog cholera virus on the reproduction of smallpox vaccine and Newcastle disease viruses]. PMID- 4317201 TI - [Preparation of highly stable reduced cytochrome c]. PMID- 4317202 TI - Vasopressin and angiotensin on resistance vessels of spleen, intestine, and liver. PMID- 4317203 TI - Fate of intravenously injected pyrophosphate-32P in dogs. PMID- 4317204 TI - Serial passage of two plaque types of parainfluenza-3 virus: changes in hemagglutinating properties and cytopathic effect. PMID- 4317205 TI - Viral flora of the gastrointestinal tract of newly imported juvenile chimpanzees. PMID- 4317206 TI - Mixed viral etiology of a shipping fever epizootic in cattle. PMID- 4317207 TI - Simplified assay for transamidinase activities of rat kidney homogenates. PMID- 4317208 TI - The retina and optic nerve. PMID- 4317209 TI - A heat labile fructosediphosphate aldolase from cold-adapted Antarctic fishes. PMID- 4317210 TI - [The mechanism of the effect of adrenocorticotropic hormone and hydrocortisone on the activity of tissue hexokinase]. PMID- 4317211 TI - [Enzyme activity distribution in the subcellular fractions from various regions of rat brains extracted by means of gradient centrifugation]. PMID- 4317212 TI - [Mitotic changes in RES (clone 1) cultures infected with Sendai virus]. PMID- 4317213 TI - [Differential diagnosis and ambulatory care of proctological diseases]. PMID- 4317214 TI - Plasma renin activity in patients with coarctation of the aorta. A comment of the pathogenesis prestenotic hypertension. PMID- 4317215 TI - Adrenal cortex, aldosterone, and hypertension. Report of an international workshop. PMID- 4317216 TI - Antenatal sex determination. A historical review. PMID- 4317217 TI - [Identification of chicken leukosis virus strains, isolated in Germany]. PMID- 4317218 TI - [The effect of smallpox virus on the mitotic regime of cell cultures RES (clone 1)]. PMID- 4317219 TI - In vitro interaction of mouse hepatitis virus and macrophages from genetically resistant mice. I. Adsorption of virus and growth curves. AB - Peritoneal macrophages from genetically resistant C(3)H mice and genetically susceptible Princeton (PRI) mice adsorbed the MHV (PRI) strain of mouse hepatitis virus equally well. The difference between the permissive cells and the nonpermissive ones seems to reside in the ability of the former to "eclipse" the virus and, subsequently, support virus replication. C(3)H cells exposed to low multiplicities of the virus remained intact with no demonstrable viral replication. Virus, taken up by the resistant cells, was protected from heat and underwent slow inactivation while few or no virus particles were released into the medium. PMID- 4317221 TI - [Listeriasis, toxoplasmosis and cytomegalovirus infections during pregnancy]. PMID- 4317220 TI - In vitro interaction of mouse hepatitis virus and macrophages from genetically resistant mice. II. Biological characterization of a variant virus MHV (C3H) isolated from stocks of MHV(PRI). AB - A variant mouse hepatitis virus MHV(C(3)H) to which cultured peritoneal macrophages from both PRI and C(3)H mice were susceptible was isolated from stocks of the MHV(PRI) strain of mouse hepatitis virus. It was cloned on C(3)H macrophage monolayers and killed both adult PRI and C(3)H mice when injected intraperitoneally. This new variant was antigenically indistinguishable from the wild type virus. While the emergence of the variant virus was delayed in the course of infecting C(3)H macrophages with large inocula of MHV(PRI), the second passage grew to a high titer in both cell types without delay. Thus, adaptation to the new host was immediate. Interference, apparently not interferon-mediated, between the two variant viruses may have been the cause for the delay in the emergence of the variant virus. The delayed destruction of C(3)H-cultured macrophages by large inocula of MHV(PRI) uniformly resulted in the emergence of MHV(C(3)H). Whether the new variant emerged as a result of a selection of a pre existing stable mutant or was conditioned by "growth" in the resistant host was not determined. PMID- 4317222 TI - Effects of renal artery constriction and subsequent contralateral nephrectomy on the blood pressure, plasma renin activity, and plasma renin substrate concentration in rabbits. PMID- 4317223 TI - [Malignant tumor in children]. PMID- 4317224 TI - Direct lymphography of the breast. PMID- 4317225 TI - [Eosinophilic granuloma of the rectum]. PMID- 4317227 TI - Nursing care of glaucoma patients. PMID- 4317226 TI - Clinical evaluation of "quantitative" rheoencephalography. PMID- 4317228 TI - Reconstruction of the cervical esophagus. PMID- 4317229 TI - Control of acute mycoplasmal and viral respiratory tract disease. PMID- 4317230 TI - [Resources in psychiatric after care strengthened in Kronoberg county]. PMID- 4317231 TI - Inhibition by prostaglandin E2 of sympathetic neurotransmission in the rabbit heart. PMID- 4317232 TI - The stimulating effect of angiotensin and vasopressin on adenosine triphosphatase activity in vitro. PMID- 4317233 TI - Influence of stress, adrenalectomy and age on the stimulation in vitro of rat kidney ATPase by angiotensin. PMID- 4317234 TI - Effect of hypobaric hypoxia on MM virus infection. PMID- 4317235 TI - Effects of helium at ambient pressure and 60 atmospheres on the acitivity of hepatic glucose-6-phosphatase and glucose-6-phosphate dehydrogenase in the mouse. PMID- 4317236 TI - Home from hospital. PMID- 4317237 TI - Cytomegalovirus infection with Lymphadenopathy. PMID- 4317238 TI - [Mechanism of morphogenetic necrosis in chick embryo foot]. PMID- 4317239 TI - [A new model for NAD+ dependent isocitrate dehydrogenase]. PMID- 4317240 TI - Viruses and cancer: herpes virus vaccine protests against Marek's disease of chickens. PMID- 4317242 TI - Preliminary virological and immunological studies of the salivary gland tumor of C3H-He mouse. PMID- 4317241 TI - Ganglion-blocking, neuromuscular-blocking and other actions of 2-imino-4 ethyloxycarbonyl-1,3-diazacycloheptane hydrochloride (OG 30), a ganglionic stimulant. PMID- 4317243 TI - Viruses in the aetiology of cancer. PMID- 4317244 TI - Production of free radicals in DNA and inactivation of its biological activity by gamma-rays. PMID- 4317245 TI - Retention of functional coding properties by polyribosomes in the x-irradiated mammalian cell. PMID- 4317246 TI - Production of hydrogen atoms in irradiated frozen aqueous alcohol solutions. An E.S.R. study. PMID- 4317247 TI - Catecholamine excretion in forty children with sympathoblastoma. PMID- 4317249 TI - [Insuloma]. PMID- 4317248 TI - Maternal virus infection after the first trimester of pregnancy and status of offspring to 4 years of age in a predominantly Negro population. PMID- 4317250 TI - [Nephrosis syndrome in adults]. PMID- 4317252 TI - Utilization of paraffin-embedded material for electron microscopy. Study of an A2 cell type microadenoma of the endocrine pancreas. PMID- 4317251 TI - Ultrastructural and biochemical characteristics of endoplasmic reticulum fractions of the Morris 7800 and Reuber H-35 hepatomas. PMID- 4317253 TI - [Cushing's syndrome with special reference to our 30 cases]. PMID- 4317254 TI - [Adenovirus infections]. PMID- 4317255 TI - [Japanese encephalitis]. PMID- 4317256 TI - Catecholamine-releasing agent recovered from plasma of subjects with arterial hypertension. PMID- 4317257 TI - A transient cytotoxic host response to the Rous sarcoma virus-induced transplantation antigen. PMID- 4317258 TI - Two mechanisms of cell resistance to repeated stimulation of interferon. PMID- 4317259 TI - Properties of rhinovirus plaque mutants. PMID- 4317261 TI - Cultures of segments of human fetal intestine: applications to cytologic and virologic investigations. PMID- 4317260 TI - Metabolism of labeled nicotinamide coenzyme in different organs of mice and rats. PMID- 4317262 TI - Virus-induced chromosome pulverization in human diploid cells. PMID- 4317263 TI - Effect of statolon on aerogenic immunization of mice with mengovirus-37A. PMID- 4317264 TI - Adrenal protein synthesis and corticosteroid production in man. PMID- 4317265 TI - A new serological technique for identification of adenovirus infections. PMID- 4317266 TI - [Attempt at treatment with methisazone of an infant with vaccinia and herpes simplex viruses]. PMID- 4317267 TI - Congenital iliac anomaly with sciatic palsy. PMID- 4317268 TI - Calciphylactic syndrome in pigs. PMID- 4317269 TI - Total Co2, lactate, and pyruvate in brain biopsies taken after freezing the tissue in situ. PMID- 4317270 TI - Clinical, electroencephalographical and neuropharmacological studies in syndromes of progressive myoclonus epilepsy. PMID- 4317272 TI - [Distribution of various forms of synapses on pyramidal neurons of the cutaneo motor areas of the brain cortex in rats]. PMID- 4317271 TI - Further studies of adrenal weight-maintaining activity in the plasma of patients with Cushing's disease. PMID- 4317273 TI - The pigment of comedones. PMID- 4317274 TI - Liver scanning in surgical practice. PMID- 4317275 TI - Mucus-secreting adenocarcinoma of anal gland origin. PMID- 4317276 TI - [Variations, in lamb serum, of the level of antibodies inhibiting hemagglutination by Myxovirus parainfluenzae during the first 3 months]. PMID- 4317277 TI - [Viremia in shep inoculated with aphthous fever virus]. PMID- 4317278 TI - Lipogenesis in homogenates of human adipose tissue. PMID- 4317279 TI - The effect of a natriuretic dose of angiotensin on rabbit kidney composition. PMID- 4317280 TI - Effect in the conscious dog of constriction of the renal artery to a sole remaining kidney on haemodynamics, sodium balance, body fluid volumes, plasma renin concentration and pressor responsiveness to angiotensin. PMID- 4317281 TI - Initiation of mitosis independent of DNA synthesis in a polyoma virus-infected confluent cell culture. PMID- 4317282 TI - Effects of x-rays on pectin studied by electron spin resonance. PMID- 4317284 TI - Kinetic studies on the biosynthesis of corticosteroids in vitro from exogenous precursors by the interrenal glands of the normal, corticotrophin-treated and adenohypophysectomized Xenopus laevis Daudin. PMID- 4317285 TI - Effect of corticotrophin and corticosteroids on oestrus, ovulation and oestrogen excretion in the sow. PMID- 4317283 TI - The role of interferon in the protective effect of a synthetic double-stranded polyribonucleotide against intranasal vesicular stomatitis virus challenge in mice. AB - Intravenous injection of polyinosinic acid/polycytidylic acid [(poly rI).(poly rC)] offered significant protection against intranasal challenge of young mice with vesicular stomatitis virus (VSV). Optimal protection was obtained when a single dose was administered 2 hr before virus challenge, but repeated doses were effective when started as late as 3 days after virus challenge. The therapeutic ratio or ratio of maximum tolerated dose to minimum effective dose for a single intravenous injection of (poly rI).(poly rC) 2 hr before virus inoculation was >/=8 mg/kg:0.004 mg/kg or >/=200.Dose-response curves for interferon production and antiviral protection by (poly rI).(poly rC) were closely parallel. Equivalent doses of poly rI or poly rC alone did not exert any interferon-inducing capacity or protective effect on intranasal VSV challenge. Several factors, which are known to potentiate or antagonize interferon production, increased or decreased the interferon-inducing capacity and antiviral protection of either (poly rI).(poly rC) or maleic acid/divinyl ether copolymer (MA/DVE) in parallel. Interferon production and antiviral protection by MA/DVE were enhanced by arginine but abolished by prior treatment with MA/DVE; DEAE-dextran (intraperitoneally), kinetin riboside and isopentenyladenosine, and prior injection of endotoxin reduced both interferon production and antiviral protection by (poly rI).(poly rC). Treatment with exogenous interferon in amounts which closely mimicked the levels of circulating interferon produced endogenously by an effective dose of (poly rI).(poly rC) gave protection against intranasal VSV which was identical with that dose of (poly rI).(poly rC). This strongly suggests that interferon production accounts for the whole protective effect of (poly rI).(poly rC) in the intranasal VSV assay. PMID- 4317286 TI - Kinetics of distribution of radioactive perchlorate in rat and guinea-pig thyroid glands. PMID- 4317287 TI - Effect of adrenocorticotrophic and growth hormones on aldosterone production and plasma renin activity in chronically hypophysectomized sodium-deficient rats. PMID- 4317288 TI - The effect of 'training' on the release of corticotrophin in response to minor stressful procedures in the rat. PMID- 4317289 TI - Relapsing corticosteroid-dependent polyneuritis. AB - Three patients are described with chronic polyneuritis of unknown cause in whom a state of corticosteroid dependence developed. A fatal relapse occurred in one patient. No clinical, electrophysiological, or pathological features were found from which it would have been possible to predict this form of response to treatment. PMID- 4317290 TI - Synaptic processing of taste-quality information in the nucleus tractus solitarius of the rate. PMID- 4317292 TI - Follow-up programs for emotionally restored patients: some issues and considerations. PMID- 4317293 TI - [Clinically atypical histiocytofibroma]. PMID- 4317291 TI - Evoked sustained focal potentials and membrane potential of neurons and of unresponsive cells of the spinal cord. PMID- 4317294 TI - Psychiatry and the community. PMID- 4317295 TI - [Considerations and suggestions for a new classification of silica compound pneumoconiosis and for a new pathogenetic or ionic theory]. PMID- 4317296 TI - [Statistical data on the cortisolemic curves after inhibition and stimulation in normal subjects]. PMID- 4317297 TI - Poultry: principles of disease control. 3. Vaccination. PMID- 4317298 TI - Karyometric studies on the reactivity of the adrenal cortex of newborn rats. PMID- 4317299 TI - Enhancement of insulin release to acute glycaemic stimulation with depression of basal insulin production rates in insulinoma following diazoxide administration. PMID- 4317300 TI - Pituitary-adrenal activation in rats with medial basal hypothalamic islands. PMID- 4317301 TI - Comparison of effects of 6-dehydro-16-methylene-hydrocortisone (STC 407) and dexamethasone on the suppression of the hypothalamo-pituitary-adrenal system. PMID- 4317302 TI - Effect of 6-dehydro-16-methylene-hydrocortisone and dexamethasone on the release of ACTH from rat pituitary glands in vitro. PMID- 4317303 TI - [Infectious pathology. II. Viral pathology]. PMID- 4317305 TI - [Conduction of impulses in excitable tissue with continuously distributed refractivity]. PMID- 4317304 TI - [Circular dichroism of single-strand DNA]. PMID- 4317306 TI - [Reactive properties of complex physiological objects]. PMID- 4317307 TI - [ESR study of free radicals appearing during UV irradiation of germinating seeds]. PMID- 4317308 TI - [Continuous description of the work of neuron impulse models]. PMID- 4317309 TI - [Various conditions for spectrophotometric determination of succinate dehydrogenase and cytochrome oxidase activity in cerebral mitochondria]. PMID- 4317311 TI - [Stimulation of the growth and artificial heterogenization of tumors by vacuolating SV40 virus and type 16 adenovirus]. PMID- 4317310 TI - [Antibodies to deoxyribonucleic acid in the serum of humans and animals with tumors]. PMID- 4317313 TI - [Epstein-Barr virus, infectious mononucleosis and Burkitt's lymphoma]. PMID- 4317312 TI - [Significance of serum transaminase changes following application of tri iodinated, biliary contrast media]. PMID- 4317314 TI - [Intradermoreaction with inactivated herpetic virus. II. Relations between the cutaneous response circulating herpetic antibodies]. PMID- 4317316 TI - Requirement of adenosine 3', 5'-cyclic phosphate for flagella formation in Escherichia coli and Salmonella typhimurium. AB - Adenosine-3',5'-cyclic phosphate (cyclic AMP) is absolutely required for flagella formation and, hence, motility in cyclic AMP-deficient mutants of Escherichia coli and Salmonella typhimurium. PMID- 4317315 TI - The distribution of carboxylic esterases in the area postrema of the guinea pig. PMID- 4317318 TI - The ultrastructural localization of nonspecific phosphatases in the intestinal epithelium of Ascaris suum. PMID- 4317317 TI - Perchloric acid extraction of deoxyribonucleic acid from thin sections of epon araldite-embedded material. PMID- 4317319 TI - Reticuloendothelial stimulation and drug metabolism. PMID- 4317320 TI - [Recent studies on insulin with special reference to Spanish publications 1951 69]. PMID- 4317321 TI - Postsynaptic action of cobra toxin at the myoneural junction. PMID- 4317322 TI - Hereditary adrenocortical unresponsiveness to ACTH--another case. PMID- 4317323 TI - [Diagnostic significance of plasma 11-hydroxycorticoid determination using the abbreviated synacthen test]. PMID- 4317324 TI - Macrophages and viral immunity. PMID- 4317325 TI - [Light and electron microscopic studies of granulated cells in the human endometrium]. PMID- 4317326 TI - [Assessment of some methods of laboratory diagnosis of acute respiratory diseases of the viral etiology in young children]. PMID- 4317327 TI - Effect of different experimental interventions on the amount of ACTH in the median eminence of the domestic pigeon. PMID- 4317328 TI - Analysis of the in situ electrical activity of nerves in fresh-water mussel (Anodonta cygnea L.). PMID- 4317329 TI - [Generalized viral infections]. PMID- 4317331 TI - Management of hyperfunction of the facial nerve. PMID- 4317332 TI - Analysis of the process of sheath expansion in swollen nerve fibers. PMID- 4317333 TI - Changes in neuronal activity in association cortex of the cat in relation to sleep and wakefulness. PMID- 4317334 TI - Time course of pyramidal activation of pontine nuclei cells in the cat. PMID- 4317335 TI - Red nuclear and interposate nuclear excitation of pontine nuclear cells. PMID- 4317336 TI - Transcallosal excitatory postsynaptic potentials of fast and slow pyramidal tract cells in cat sensorimotor cortex. PMID- 4317337 TI - Sleep stages, REM deprivation and electroconvulsive threshold in the cat. PMID- 4317338 TI - [Problems in the pathogenesis of Herpes simplex virus infections]. PMID- 4317339 TI - [Reducation of NAD linked with the presence of ferredoxin by acellular extracts of Clostridium acetobutylicum]. PMID- 4317340 TI - [Determination of serum 11-hydroxycorticosteroids (11-OHCS) in the clinical laboratory--rapid ACTH test]. PMID- 4317342 TI - Sleep requirements and the characteristics of some sleepers. PMID- 4317341 TI - The pharmacology of disordered sleep: a laboratory approach. PMID- 4317343 TI - Cushing's syndrome caused by a metyrapone responsive adrenocortical adenoma. PMID- 4317344 TI - Characterization of the Kilham rat virus. AB - Kilham rat virus (KRV) was found to grow in a rat nephroma cell line and to form plaques on secondary rat embryo monolayers. The virus was purified by enzymatic treatment and isopycnic cesium chloride sedimentation. KRV bands at a density of 1.41 g/cm(3) in cesium chloride. It contains about 26.5% deoxyribonucleic acid (DNA). The sedimentation coefficient S(20,w) in sucrose gradients was 122 corresponding to a molecular weight of 6.6 x 10(6) daltons. The reaction of formaldehyde with the KRV virion suggests that the DNA in situ is single stranded. DNA extracted from KRV had a buoyant density of 1.715 g/cm(3) in cesium chloride. The S(20,w) was determined in sucrose gradients to be 16, and the molecular weight was calculated to be approximately 1.7 x 10(6) daltons. The base composition of the DNA is 26.7% adenine, 30.8% thymine, 20.0% guanine, and 22.5% cytosine. On the basis of its noncomplementary nucleotide ratio, melting curve, and the reaction with formaldehyde, the DNA of KRV is believed to be single stranded. PMID- 4317345 TI - Purification, characterization, and attempts at isotopic labeling of mouse interferon. AB - Under optimal conditions which minimized the accumulation of extraneous proteins, interferon preparations were obtained in L cells containing from 2 x 10(4) to 5 x 10(4) units/mg of protein. The radiolabeled proteins were liberated simultaneously with interferon from cultures exposed to tritiated amino acids after viral stimulation and from corresponding controls, and were subsequently purified with the following results. Chromatography of interferon on carboxymethyl-Sephadex C-25 eliminated selectively unlabeled or poorly labeled proteins, resulting in a greater than sixfold increase in counts per minute per milligram of protein. Similarly purified control material harbored at least 12 times less tritium per milligram of protein than interferon, and the label was more diversely distributed among proteins of different molecular weights. On electrophoresis of interferon in polyacrylamide gels, labeled proteins were reduced further by a factor of at least 10 without loss in titer. Final purification was estimated at greater than 280-fold, representing a calculated specific activity of at least 1.4 x 10(7) units of interferon per milligram of protein. PMID- 4317346 TI - Effect of persistent fibroma virus infection on susceptibility of cells to other viruses. AB - Shope fibroma virus establishes a persistent cytoplasmic infection in primary (RK) and serially cultivated (DRK(3)) rabbit kidney cells which is accompanied by a morphological alteration of the cells. The response of such cells to superinfection by other viruses was compared with that of control cells by determining plaque production and virus yield of superinfecting viruses. It was found that the growth of other poxviruses, myxoma and vaccinia, was greatly inhibited in the fibroma virus-infected cells, but that of pseudorabies and herpes simplex viruses, which are unrelated deoxyribonucleic acid viruses, was virtually unaffected. The ribonucleic acid (RNA) viruses, poliovirus 1 and coxsackievirus B1, did not produce plaques on either RK or fibroma virus-infected (F-RK) monolayers. However, the growth of several other RNA viruses, vesicular stomatitis virus, encephalomyocarditis virus, Sindbis virus, and Newcastle disease virus, was enhanced in F-RK cells. None of these latter RNA viruses produced any infectious progeny in DRK(3) cells, but they all plaqued on and produced good yields in DRK(3) cells persistently infected with fibroma virus. This phenomenon is termed facilitation. Facilitation results from the infection of DRK(3) cells by fibroma virus. Neither interference nor facilitation were due to changes in the adsorption or eclipse of the superinfecting virus. PMID- 4317347 TI - Growth kinetics of Yaba tumor poxvirus after in vitro adaptation to cercopithecus kidney cells. AB - Yaba tumor poxvirus has been adapted to continuous in vitro cultivation in monolayers of cercopithecus kidney cells. At 35 C, the minimum replicative cycle, after synchronous infection of CV-1 cells with multiplicity of infection of 135 focusforming units per cell, was 35 hr; however, maximum virus yields were not obtained until 75 hr postinfection (PI). Cytoplasmic incorporation of (3)H thymidine [viral deoxyribonucleic acid (DNA) synthesis] was detected 3 hr PI and was preceded by synthesis of nonstructural associated antigens (YS). Synthesis of YS antigens was not inhibited by the DNA inhibitor, arabinofuranosyl cytosine (ARA-C). Synthesis of at least two virion structural antigens, although not detected by immunofluorescence until 2 hr after the onset of DNA synthesis, occurred in the presence of ARA-C, indicating potential translation of these structural antigens from parental DNA. The first progeny DNA was completed by 20 hr PI but was not detected in infectious form until 35 hr PI. The maximum rate of progeny DNA completion occurred between 20 and 30 hr PI. DNA synthesis continued 45 to 50 hr PI. The adapted virus retained its oncogenicity and, like the wild type, replicated better at 35 C than at 37 C. A synthetic step associated with viral DNA synthesis appears to be temperature-sensitive. PMID- 4317348 TI - Immunodiffusion analysis of Yaba poxvirus structural and associated antigens. AB - Yaba poxvirus virions were extracted and purified from Rhesus monkey tumors. A saline-soluble virion fraction (Y-xp), obtained by mechanical fractionation of purified virions with an X-press, contained seven components in acrylamide gel electrophoresis; five of these components were reactive in immunodiffusion with whole virion and Y-xp antisera produced in rabbits and monkeys. The saline insoluble residue remaining after X-press treatment was hydrolyzed with sodium dodecyl sulfate, urea, and 2-mercaptoethanol (SUM). This fraction, Y-sum, contained five components, four of which were demonstrable by immunodiffusion. There was no evidence of antigenic relationships between Y-xp and Y-sum antigens in immunodiffusion. In acrylamide gel electrophoresis, one Y-xp and one Y-sum component had similar mobilities. Y-xp but not Y-sum antisera contained viral neutralizing antibodies. Virus-free saline extracts of Yaba tumor prepared with Genetron (YS) were essentially devoid of virion structural antigens. They failed to induce precipitating antibodies for virion antigens, were nonreactive in immunodiffusion with virion antisera, and gave low complement-fixation titers with virion antisera. Yaba virion antigens were recovered from the Genetron tumor sediment by SUM and alkaline hydrolysis. Antisera prepared to YS extracts gave a maximum of 17 precipitin lines in immunodiffusion with YS extracts; none was identified as a virion structural antigen. Saline extracts of tumor prepared without Genetron contained immunogenic amounts of 5 virion antigens and 12 to 14 associated antigens. Animals immunized with infected cell culture extracts (virus free) formed antibodies to six to seven virion antigens. The implications of using extracts of Yaba poxvirus-infected tissues in complement-fixation tests to measure virion antibodies were discussed. PMID- 4317349 TI - Host-range restrictions of murine leukemia viruses in mouse embryo cell cultures. AB - Murine leukemia virus strains fall into three categories with respect to their ability to propagate in cells of National Institutes of Health (NIH) Swiss and BALB/c mouse embryos. Cultures of NIH cells are 100- to 1,000-fold more sensitive to "N-tropic" strains than BALB/c cell cultures, but are 30- to 100-fold less sensitive to "B-tropic" strains. Some virus strains (dually tropic or "NB tropic") propagate equally well in both cells. M-MSV pseudotypes show the host range characteristics of the virus supplying the envelope, both in vitro and in vivo. The host-range characteristics appear to be genetically determined and could not be explained by host-induced modification or virus mixtures. There was no correlation between host range and Gross-AKR or FMR serotype. PMID- 4317350 TI - Electron microscopy of the nucleic acid of mouse mammary tumor virus. AB - Mouse mammary tumor virus (MTV) was isolated from the milk of RIII mice by density-gradient centrifugation in Ficoll. The homogeneity of the preparation was demonstrated in electron micrographs. The nucleic acid was extracted with phenol in the presence of Pronase. Its viral origin was attested by failure of ribo nuclease and deoxyribonuclease treatment of the virus preparation to destroy the filamentous molecules; after phenol extraction, the molecules were destroyed by ribonuclease but not by deoxyribonuclease. Rotary shadowed preparations were examined in the electron microscope. The length distribution of the RNA filaments showed peaks at 1.2, 2.4, and 3.6 mum. The molecular weight of the longest molecule of MTV-RNA was estimated as 3.6 x 10(6) daltons. PMID- 4317352 TI - Base sequence and evolution of guinea-pig alpha-satellite DNA. PMID- 4317353 TI - Requirement of serum for DNA synthesis in BHK 21 cells: effects of density, suspension and virus transformation. PMID- 4317354 TI - Topoinhibition and serum requirement of transformed and untransformed cells. PMID- 4317351 TI - Purified rabbit interferon: attempts to demonstrate interferon-specific 3H protein. AB - (3)H-protein present in highly purified preparations of rabbit interferon was not conclusively separated from noninterferon, cellular (14)C-proteins by co chromatography on carboxymethyl-Sephadex or by co-electrophoresis on acid or neutral polyacrylamide gels. PMID- 4317355 TI - Lee wave hypothesis for the initial pattern of spread during the 1967-68 foot and mouth epizootic. PMID- 4317357 TI - [16 cases of splenoportal obstruction]. PMID- 4317356 TI - Immunodepression by mammalian viruses and plasmodia. PMID- 4317358 TI - Radio-induced mutants of the Schmidt-Ruppin strain of rous sarcoma virus. PMID- 4317359 TI - Single-stranded oligonucleotides from reovirus type 3. PMID- 4317360 TI - Soluble RNA polymerase complex from poliovirus-infected HeLa cells. PMID- 4317361 TI - Requirement for cell replication after SV40 infection for a structural change of the cell surface membrane. PMID- 4317362 TI - Plasma membrane lipids and parainfluenza virus assembly. PMID- 4317363 TI - Herpes simplex virus structural proteins. PMID- 4317364 TI - Susceptibility to superinfection of simian cells transformed by SV 40. PMID- 4317365 TI - Synthesis of double-stranded RNA by poliovirus temperature-sensitive mutants. PMID- 4317367 TI - Considerations on the importance of rapid eye movements on visual dreams. PMID- 4317366 TI - A new type of variation among the polyoma viruses characterized by cytoplasmic accumulation of capsid antigen. PMID- 4317368 TI - Determination of picomole amounts of enzymatically formed adenosine 3',5'-cyclic monophosphate by high pressure anion exchange chromatography. PMID- 4317369 TI - [Experience with the use of mobile laboratories in the Ivory Coast]. PMID- 4317370 TI - [The effect of 2,4,6-triethylene-imino-s-triazine and x-rays on chick embryo phosphatases]. PMID- 4317371 TI - [An analysis of the features of transmission of excitation from nerve to muscle in curarized dogs of different ages]. PMID- 4317372 TI - [Facilitation of the spinocervical tract under the influence of impulses from a focus of inflammation]. PMID- 4317373 TI - [Hemmorrhagic pleurisy following bronchography with lipiodol]. PMID- 4317374 TI - [Behavior of renal glucose-6-phosphatase in experimental alloxan diabetes in rats]. PMID- 4317375 TI - [Benign bronchial and lung neoplasms]. PMID- 4317376 TI - [Recurrence and metastases in bronchial adenoma]. PMID- 4317377 TI - [Proresid-methotrexate combination in chemotherapy of orofacial carcinoma]. PMID- 4317378 TI - [Suprapapillary duodenal carcinoma within heterotopic pancreatic islets]. PMID- 4317379 TI - Calcification in the liver, an unusual feature of ductal cell hepatic carcinoma. Report of a case. PMID- 4317380 TI - Abnormalities in hepatic enzyme activities during development of diabetes in db mice. PMID- 4317381 TI - Effect of weight and cell size on hormone-induced lipolysis in New Zealand obese mice and American obese hyperglycemic mice. PMID- 4317382 TI - Glycolytic and gluconeogenic enzyme activities in the hereditary obese hyperglycemic syndrome and in acquired obesity. PMID- 4317383 TI - Effects of glucagon, dibutyryl cyclic 3',5'-adenosine monophosphate, and theophylline on calcitonin secretion in vitro. AB - The secretion of calcitonin by slices of porcine thyroid glands has been investigated. Calcitonin in the incubation medium was determined by radioimmunoassay. Secretion of calcitonin was diminished when calcium or magnesium was omitted and was increased stepwise as the concentration of calcium or magnesium in the incubation medium was increased. Calcitonin secretion was augmented substantially when either the quantity of thyroid tissue or volume of incubation medium was increased. Secretion of calcitonin was stimulated by glucagon, theophylline, and dibutyryl cyclic 3',5'-adenosine monophosphate. It is concluded that calcitonin secretion is regulated by the concentration of calcium and magnesium, that secretion may be inhibited by calcitonin or a precursor and that secretion can be stimulated by increasing the concentration of cyclic 3',5' adenosine monophosphate in the parafollicular cells of the thyroid gland. PMID- 4317384 TI - Abnormally sustained aldosterone secretion during salt loading in patients with various forms of benign hypertension; relation to plasma renin activity. AB - Among 25 patients with benign, essential hypertension, and an equal number with other benign forms of hypertension, without serious cardiac, renal, or cerebrovascular impairment, 41 cases failed to reduce aldosterone excretion rates into the normal range (less than 5 mug/day) on a daily intake of 300 mEq of sodium. The hypertensive patients excreted slightly less than the normal fraction of labeled aldosterone as acid-hydrolyzable conjugate. Secretion rates were significantly higher in the hypertensive patients than in normotensive controls taking the high-sodium intake. On a 10 mEq sodium intake, the increase in excretion and secretion rates of aldosterone in the hypertensive patients could be correlated with plasma renin activity (PRA). The patients with the least increase in PRA had subnormal increase in aldosterone secretion and excretion, while unusually large rises in aldosterone secretion accompanied high PRA, especially in the cases with increased plasma angiotensinogen induced by oral contraceptives. The persistence of inappropriately high aldosterone secretion in most hypertensive patients during sodium loading could be related to a higher PRA than that found in normotensive controls under comparable conditions. In other hypertensives, whose PRA was unresponsive to sodium depletion, there was no significant correlation between PRA and aldosterone output, and no known stimulus to aldosterone production was detected. Five obvious cases of hyperaldosteronism were found among the 16 low-renin patients. The cause of the nonsuppressible aldosterone production in the other low-renin cases remains to be determined. PMID- 4317385 TI - [Study in utero of wakefulness and sleep states in guinea pigs]. PMID- 4317386 TI - [Dynamic response to stress and A.C.T.H. of the regenerated adrenal cortex after neonatal graft]. PMID- 4317387 TI - [Some aspects of 3'5'AMP catabolism in rat liver]. PMID- 4317388 TI - [Increasing of synthesis and utilization of serotonin (5HT) in central nervous system (SNC) of rats during deprivation of paradoxical sleep (SP)]. PMID- 4317389 TI - [Stress during experimental deprivation of paradoxical sleep]. PMID- 4317390 TI - Spontaneous infection in ex-germfree guinea pigs due to Clostridium perfringens. PMID- 4317392 TI - Adsorption chromatography: scope, technique and equipment. PMID- 4317391 TI - Cross infection with eighteen pathogens among caged laboratory animals. PMID- 4317393 TI - Ion-exchange chromatography. PMID- 4317394 TI - The control of sample migration. PMID- 4317395 TI - V. Band migration as a function of the molecular structure of the sample. PMID- 4317396 TI - [Social service in the psychiatric hospital]. PMID- 4317397 TI - The effect of lymphography with Lipiodol ultrafluide on the barrier function of the lymph node. An experimental investigation in rabbits. PMID- 4317398 TI - Problems of differential diagnosis in angiography of the pancreas. PMID- 4317399 TI - [Current trends in hormone therapy]. PMID- 4317400 TI - Cancer viruses in primates. PMID- 4317401 TI - Prostaglandin receptor site: evidence for an essential role in the action of luteinizing hormone. AB - A dose-response relation was established between prostaglandins and formation of adenosine 3',5'-monophosphate in the mouse ovary. The prostaglandin antagonist, 7 oxa-13-prostynoic acid, blocked the stimulatory effect of prostaglandin E(1), prostaglandin E(2), and luteinizing hormone on adenosine 3',5'-monophosphate formation in a competitive manner. Kinetic studies made it possible to suggest that there is a single luteinizing-hormone-related prostaglandin receptor in mouse ovaries, and that activation of this prostaglandin receptor is an essential requirement in the action of luteinizing hormone to stimulate adenosine 3',5' monophosphate formation and steroidogenesis. PMID- 4317402 TI - Lysosomal enzyme activity in rats with adjuvant-induced arthritis. PMID- 4317403 TI - Trigeminal neuropathy in connective tissue disease. PMID- 4317404 TI - Alveolar cell carcinoma occurring in idiopathic interstitial pulmonary fibrosis. PMID- 4317405 TI - Homologous viral interference: induction by RNA from defective particles of vesicular stomatitis virus. AB - The viral RNA isolated from the defective particles of vesicular stomatitis virus was capable of interfering with the replication of this virus in chick embryo cells. The data indicate that the interfering ability of the defective particles of this virus is due to their nucleic acid component. PMID- 4317406 TI - [ESR spectra of iron complexes with nucleic acid components]. PMID- 4317407 TI - [Action of modifying agents on free radicals in irradiated enzymes as related to their inactivation by radiation. Effect of oxygen]. PMID- 4317408 TI - [Comparative study of parameters of the ESR spectra of lyophilized biological objects and of semiquinone free radicals fixed on different surfaces]. PMID- 4317409 TI - [H-D exchange reactions of free radicals in irradiated crystals of d,l-serine]. PMID- 4317410 TI - [Free radical states of cellular and subcellular components]. PMID- 4317411 TI - [Kinetic studies of the content of free radicals in lyophilized tissues of malignant tumors]. PMID- 4317412 TI - [The effect of cholinergic substances and adrenaline on the duration of the bioelectric activity of the heart in acute asphyxia]. PMID- 4317413 TI - [Monosynaptic reflex changes during development of nerve dystrophy]. PMID- 4317414 TI - [Antigenic changes in the mammary gland tissues of line A mice during their postnatal growth]. PMID- 4317415 TI - [The interaction between tumor cells, vacuolizing SV40 virus and type 16 adenovirus]. PMID- 4317416 TI - [Corticotropic activity and "C.R.F." in median eminence, and corticotropic activity of hypophyseal grafts in pigeons]. PMID- 4317417 TI - [Nephroblastic dysembryoma "line DNV" of chicken. Observations on 10 generations of experimental transmission]. PMID- 4317418 TI - [A new allotype Gm in humans: the factor Bet probable racial "marker"]. PMID- 4317419 TI - Adult and embryonic transfer RNA. PMID- 4317420 TI - The cell nucleus. PMID- 4317421 TI - [Biosynthesis of N-glycoloylneuraminic acid by an ascorbic acid- or NADP dependent N-acetyl hydroxylating "N-acetylneuraminate: O2-oxidoreductase" in homogenates of porcine submaxillary gland]. PMID- 4317422 TI - [Microsomal NADH-dependent electron transport]. PMID- 4317423 TI - Kinetics of rabbit muscle lactate dehydrogenase over a large concentration range. PMID- 4317424 TI - Family-centered aftercare for young adults. PMID- 4317425 TI - Studies on the phosphorylation and activation of skeletal muscle phosphorylase and phosphorylase kinase in vivo. PMID- 4317426 TI - Mechanism of ethanol suppression of gluconeogenesis. Inhibition of phosphoenolpyruvate synthesis from glutamate and alpha-ketaglutarate. PMID- 4317427 TI - 2,3-diphosphoglycerate phosphatase from human erythrocytes. General properties and activation by anions. PMID- 4317429 TI - The management of malignant tracheal neoplasms. PMID- 4317428 TI - Control factors affecting gluconeogenesis in perfused rat liver. Effects of 4 pentenoic acid. PMID- 4317430 TI - Myoblastoma of the larynx. PMID- 4317431 TI - Alopecia neoplastica. Hair loss resembling alopecia areata caused by metastatic breast cancer. PMID- 4317432 TI - [Selective isolation media for anaerobic, non-sporulating gram-negative rods. I. Basic experiment]. PMID- 4317433 TI - Chemical and immunochemical properties of glycolipids from pig spleen. PMID- 4317434 TI - [Studies on free radicals in tumor tissue of the urinary baldder. 2. Effects of spontaneous oxidization of ESR spectra]. PMID- 4317435 TI - [Studies on free radicals in tissues of carcinoma of the urinary bladder. 3. ESR spectra of tumor surrounding tissues in human urinary bladder]. PMID- 4317437 TI - [Influence of treatment in the cardiovascular reactivity of the hypertensive patient]. PMID- 4317436 TI - [Lipids, especially lysolecithin, in the chromaffin granules of different species]. PMID- 4317438 TI - [Histochemistry of catecholamines and several enzymes in the intrascleral passages of intraocular fluid outflow in glaucoma]. PMID- 4317439 TI - Large breast tumors of early adolescence. PMID- 4317440 TI - [Radioimmunological determination of plasmatic growth hormone in growth delays. Results recorded in 43 cases after stimulations with insulin and arginine]. PMID- 4317441 TI - Treatment of vitamin D-resistant hypoparathyroidism with 25 hydroxycholecalciferol. PMID- 4317442 TI - Permeability patterns in pig aorta. PMID- 4317444 TI - [The disinfectant activity of iosan against foot and mouth disease virus]. PMID- 4317443 TI - Carbohydrate metabolism in the liver and muscle in rats fed a hypercholesterolaemic diet. PMID- 4317445 TI - Varicella-Zoster encephalomyelitis. PMID- 4317446 TI - [Determination of the alpha-spiral form of polypeptide chain in proteins by electron paramagnetic resonance]. PMID- 4317447 TI - Unit activity in premarin-induced cortical epileptogenic foci. PMID- 4317448 TI - [Cytochemical characteristics of specificity of enzymes hydrolyzing thiamine pyrophosphate and nucleoside diphosphates]. PMID- 4317449 TI - Functional variation in dermatomes in the macaque monkey following dorsal root lesions. PMID- 4317450 TI - Nucleoside phosphatase activities associated with the tangles and plaques of alzheimer's disease: a histochemical study of natural and experimental neurofibrillary tangles. PMID- 4317452 TI - [Studies on the motilitry of the goat abormarum with special reference to the pylorus]. PMID- 4317451 TI - [Evolution of antibiograms of bacilli persisting under treatment in the sanatorium]. PMID- 4317453 TI - [Sleep and akinetic mutism]. PMID- 4317454 TI - Role of cell association in virus infection and virus rescue. PMID- 4317455 TI - Aspects of the EB virus. PMID- 4317456 TI - The 48-hour adrenocorticotrophin infusion test for adrenocortical insufficiency. PMID- 4317457 TI - Chemodectomas of the glomus intravagale: vagal body tumors, nonchromaffin paragangliomas of the nodose ganglion of the vagus nerve. PMID- 4317459 TI - [Axo-dendritic associations of the pyramidal neurons of the sensomotor cortex in the cat]. PMID- 4317458 TI - [Change in the activity of cytochrome oxidase and succinate dehydrogenase of rat brain mitochondria under the influence of anti-brain antibodies in immune sera and the sera of patients with neuro-psychogenic disorders]. PMID- 4317460 TI - [Selection of materials for implanted electrodes used in neurophysiology]. PMID- 4317461 TI - [Supraspinal control of synaptic processes during viscero-motor reflexes]. PMID- 4317463 TI - [Synaptic mechanisms of reverse generalization of excitation following local injury of the cerebral cortex]. PMID- 4317462 TI - [Adrenal cortex hormones and the resistance of animals of various ages to asphyxia]. PMID- 4317464 TI - [Isoelectric points of reticular cell ribonucleoproteins of transplantable lines sensitive and resistant to the action of enteroviruses]. PMID- 4317465 TI - [The receptor function of the superior cervical sympathetic ganglion]. PMID- 4317466 TI - [The inhibiting effect of tick-borne encephalitis complex viruses possessing varying neurovirulence on mouse tumors in vivo]. PMID- 4317467 TI - Wilms' tumour propagated through the inferior vena cava into the right heart cavities. AB - A report is made of a rare case of Wilms' tumour which simulated clinically a syndrome of ;right heart failure', as found in some cases of Ebstein's disease. The clinical, radiological, and electrocardiographic study led to the suspicion of this type of malformation. The cine-angiographic study revealed two important facts: the impossibility of approaching the inferior vena cava with opaque material injected into the azygos vein and a filling defect of the right atrium. The post-mortem study revealed the presence of a Wilms' tumour of the right kidney which extended into the inferior vena cava and into the right atrium without producing metastases. This seems to be the first case of this peculiar course of a Wilm's tumour which has grown into the right atrium, resulting in this bizarre clinical picture. PMID- 4317468 TI - A study of New and Old World monkeys to determine the likelihood of a simian reservoir of smallpox. AB - The author presents data indicating that three species of New World monkeys (Cebus apella, Ateles paniscus, Lagothrix lagothricha) are not susceptible to Brazilian variola minor. Although the number of animals tested was not large, no experimental evidence was obtained to suggest that these species could form a non human reservoir for smallpox in the Western Hemisphere. The results also indicate that Cercopithecus aethiops are not very susceptible to infection with either variola major or minor. Haemagglutination-inhibition tests of sera from monkeys from South America, Africa and the Philippines failed to reveal significant levels of poxvirus antibody. Previous studies have shown that Macaca irus, although susceptible to experimental infection with variola major, are not able to maintain the infection for more than a few generations of disease. The author concludes that there is as yet no clear experimental, serological or epidemiological evidence to support the hypothesis that smallpox can exist in wild simian populations. PMID- 4317469 TI - [The Papanicolaou method in the early diagnosis of intraductal neoplasms of the breast]. PMID- 4317470 TI - [Changes of the pressoactive substance extractable from both kidneys of rats with hypertension induced by complete ligation of the aorta between the renal arteries]. PMID- 4317471 TI - Preliminary observations of calcified material in villous synovitis. PMID- 4317472 TI - Pyrophosphate arthropathy and calcific periarthris. PMID- 4317473 TI - Acrosyndactyly. A study of twenty-seven patients. PMID- 4317474 TI - Incidence of Clostridium perfringens in neonatal enteritis of Montana calves. PMID- 4317475 TI - Virus production by Rous sarcoma cells. PMID- 4317476 TI - Effect of elevated dietary levels of iron on the performance and blood constituents of calves. PMID- 4317477 TI - A method for the estimation of age in the identification of mass casualties. PMID- 4317478 TI - The 30-minute Synacthen test in pregnancy and labour. PMID- 4317479 TI - An electron microscopic study of synaptic alterations in cultured mammalian central nervous tissues exposed to serum from animals with experimental allergic encephalomyelitis. PMID- 4317480 TI - Infectious canine hepatitis: a virologic and ultrastructural study. PMID- 4317481 TI - Ultrastructural aspects of herpes simplex virus infection in organized cultures of mammalian nervous tissue. PMID- 4317482 TI - [Hypoglycemias in childhood]. PMID- 4317483 TI - [Experimental studies on corticoid influence in virus infections]. PMID- 4317484 TI - [Primary and secondary resistance in 257 cases of pulmonary tuberculosis from 1964 to 1966 at the Pneumology Service in Poitiers]. PMID- 4317485 TI - Lipid composition of brain synaptic vesicle fraction. PMID- 4317486 TI - The renin-angiotensin system in experimental cirrhosis. PMID- 4317487 TI - Blockade of catatoxic steroid actions by metyrapone. PMID- 4317488 TI - [Functional peripheral sensitivity unit]. PMID- 4317489 TI - Effects of gamma-hydroxybutyrate on plasma levels of ACTH and cortisol in man. PMID- 4317490 TI - Biosynthesis of glucans in mung bean seedlings. Formation of beta-(1,4)-glucans from GDP-glucose and beta-(1,3)-glucans from UDP-glucose. PMID- 4317492 TI - 14C labeling of glucosyl oligosaccharides during starvation and during hydrocortisone-induced glycogenesis. PMID- 4317491 TI - The pyruvate dehydrogenase complex from the mitochondrial fraction of Neurospora crassa. PMID- 4317493 TI - [Mechanisms of the inhibition of the fibrogenic power of silica dust by mineral substances: role of surface conditions]. PMID- 4317494 TI - Measurement of latency in facial nerve in normal and uremic persons. PMID- 4317495 TI - [On a case of amputation neuroma of the mandibular nerve]. PMID- 4317496 TI - [Unusual histological aspects in a case of glioblastoma]. PMID- 4317497 TI - [On a case of malignant mixed tumor of the submandibular gland]. PMID- 4317498 TI - [Reparative processes in the adrenal cortex under the influence of ACTH and prednisolone]. PMID- 4317499 TI - Hydrolysis of pyrophosphate and ester phosphates by bone extracts. PMID- 4317500 TI - Vincristine (NSC-67574) therapy for Wilms' tumor. PMID- 4317501 TI - [Angiographic findings in hand malformations]. PMID- 4317502 TI - [On 10 years of experience with excision of internal mammary lymph nodes in the extended radical surgical treatment of malignant neoplasms of the breast]. PMID- 4317503 TI - [Correlation between the degree of radioactivity, morphology and dimensions of the scintigraphic imagea of various types of cerebral tumors]. PMID- 4317504 TI - Unilateral hypoplasia of the optic nerve. PMID- 4317506 TI - [Level of scleroproteins and silicon dioxide in rat lung tissue in experimental silicosis and the effect of ultrahigh frequency waves on these indices]. PMID- 4317505 TI - Surgery of the trachea. PMID- 4317507 TI - [Methods of selecting a sample of suspended dust for determining its content of free silicon dioxide]. PMID- 4317508 TI - Cortisol and corticosterone in bovine plasma and the effect of adrenocorticotropin. PMID- 4317509 TI - Immunochemical studies of phospholipids. VI. Haptenic activity of phosphatidylinositol and the role of lecithin as an auxiliary lipid. PMID- 4317510 TI - Reaction of serum from pregnant hamsters with surface of cells transformed by SV40. PMID- 4317511 TI - Fetal antigen capable of inducing transplantation immunity against SV40 hamster tumor cells. PMID- 4317512 TI - Reciprocal neutralizing cross-reaction between rhinovirus types 9 and 32. PMID- 4317513 TI - Surgical management of thymic neoplasms. PMID- 4317514 TI - Presence of trimetaphosphatase in the turbellarian Dugesia tigrina and the relation of enzyme distribution to food uptake. PMID- 4317515 TI - Activation and release of lysosomal enzymes from isolated leukocytic granules by liposomes. A proposed model for degranulation in polymorphonuclear leukocytes. PMID- 4317517 TI - The assessment of adrenal-cortical function in patients receiving corticotrophin therapy. PMID- 4317516 TI - Viral infections in pregnancy. PMID- 4317519 TI - [Nuclear changes of HeLa cells induced by adenovirus type 8 infection]. PMID- 4317518 TI - The role of adenosine 3'-5'-cyclic monophosphate and catecholamines in the pigment migration process in Xenopus laevis. PMID- 4317520 TI - Haemagglutination-inhibition antibodies to encephalomyocarditis virus in Queensland cattle. PMID- 4317521 TI - Australia and exotic animal diseases--a reapraisal. PMID- 4317523 TI - Isolation of infective agents from cases of Marek's disease in poultry. PMID- 4317522 TI - Pneumonia in sheep. PMID- 4317524 TI - [Myelin forms in chronic gastritis observed by electron microscope]. PMID- 4317525 TI - [Relation between enzootic pneumonia (influenza of pigs) and environment]. PMID- 4317526 TI - [Inhibition of synaptic processes in motor neurons in the presence of rhythmic visceromotor influences]. PMID- 4317527 TI - [Malign bone tumors and soft tissue sarcomas of the motor apparatus. Survey on 85 cases from 1955 to 1964]. PMID- 4317528 TI - Diagnosis and results of treatment of middle lobe syndrome. PMID- 4317529 TI - [Compression of the nerve truncs of the limbs in rheumatologic diseases]. PMID- 4317530 TI - The intradermal reaction in amebiasis. AB - Studies on the amebiasis skin test were carried out in Amerindians living on reserves of Northern Saskatchewan. Results indicate the skin test to be highly sensitive in patients with acute amebic dysentery and in individuals with a history of amebic disease. A high percentage of asymptomatic school children living on a reserve where amebic disease is of common occurrence were also skin reactors. In a similar group of school children living on a reserve where amebic disease had never been reported but where E. histolytica infection rates are high there were very few reactors. A control group of white adults living in a non endemic area were uniformly negative to the skin test. A comparison with the indirect hemagglutination test showed a good general correlation, but the skin test proved to be more accurate in cases of acute amebic dysentery in children 5 years of age or under. The skin test appears to have potential as a diagnostic technique and may be of considerable value in defining endemic areas of amebic disease. PMID- 4317531 TI - Peutz-Jeghers syndrome with jejunal and colonic adenocarcinomas. PMID- 4317532 TI - Electrical activity of the human hypothalamus and midbrain during sleep. PMID- 4317533 TI - In vivo dosimetry by electron spin resonance spectroscopy. PMID- 4317534 TI - Investigation of the mechanism of action of the lipolytic agent 4-(3,4 dimethoxybenzyl)-2-imidazolidinone (Ro 7-2956). PMID- 4317535 TI - Drug induction and suppression of stimulus-bound repetition in sympathetic ganglia. PMID- 4317536 TI - [Cytomegalovirus of primates]. PMID- 4317537 TI - Effect of trypsin on reproduction of type 4 parainfluenza virus in Vero cell cultures under fluid overlay. PMID- 4317538 TI - Alpha toxoid of Clostridium perfringens. II. Immunogenicity of the toxoid. PMID- 4317539 TI - Titration of kappa toxin of Clostridium perfringens and kappa antitoxin by a modified azocoll method. PMID- 4317540 TI - Effects of the lymphocytosis-promoting factor from Bordetella pertussis on the function and potentiality of lymphocytes. I. Effect on the ability of lymphocytes to recirculate in the body. PMID- 4317541 TI - Two molecular forms of Clostridium perfringens alpha-toxin associated with lethal, hemolytic and enzymatic activities. PMID- 4317542 TI - Generalized cytomegalovirus infection in a gorilla. PMID- 4317543 TI - [Conservative treatment in carcinoid]. PMID- 4317544 TI - Experiences in laboratory diagnosis of rhinovirus infections in routine medical practice. PMID- 4317545 TI - Sarcoidosis, another disease associated with serologic evidence for herpes-like virus infection. PMID- 4317547 TI - Trick movements. PMID- 4317546 TI - [Radiotherapy of pediatric cancer]. PMID- 4317548 TI - A new theory of the termination of action of the muscle relaxants. PMID- 4317549 TI - Hepatic resection in neoplastic obstructive jaundice. A case report. PMID- 4317550 TI - A neurological disorder in porphyria cutanea tarda. PMID- 4317551 TI - Granular-cell myoblastoma of the bronchus: report of a case treated with upper lobectomy and sleeve resection of the stem bronchus. PMID- 4317552 TI - Absence of the enhanced synthesis of hippuric acid in primary hepatoma induced by azo-dye feeding. PMID- 4317553 TI - [Clinical peculiarities of primary cancer of the liver]. PMID- 4317554 TI - [Involvement of nerve trunks in diseases of veins of the lower extremities and pelvis]. PMID- 4317555 TI - The ovary of the guppy, Poecilia reticulata. The atretic follicle, a corpus atreticum or a corpus luteum praeovulationis. PMID- 4317556 TI - [Neisseria meningitidis strains isolated from patients]. PMID- 4317557 TI - Electron microscopic study of the replication of poliovirus in FL cells. PMID- 4317558 TI - Adrenocortical function during aging in the dog. PMID- 4317559 TI - Fate of the polyoma virus protein coat (capsid) in mouse embryo cells. PMID- 4317561 TI - [Extramammary Paget's disease]. PMID- 4317562 TI - [Short-latency reticulospinal synaptic projections on alpha-motor neurons]. PMID- 4317560 TI - Canine embryonal nephroma: a case report. PMID- 4317563 TI - [Adrenocorticotropin synthesis in the hypophyses of normal and irradiated rats in vitro]. PMID- 4317564 TI - [Electrocardiographic changes in the rat caused by administration of adenosine compounds. IV. Influence of ATP, 5'AMP, 3'-5' cyclic AMP and N6-2-O-dibutyryl cyclic AMP on the electrocardiographic effects of pitressin]. PMID- 4317565 TI - [Retinitis circinata therapeutically influenced by uropancreozymin]. PMID- 4317566 TI - [Evaluation of paternity probability determined according to the formula of Eseen Moller with regard to the given mother-child constellation. Description of the methods; tables and graphs]. PMID- 4317567 TI - Interaction of beta-adrenergic blocking agents with noradrenaline in vascular smooth muscle. PMID- 4317568 TI - A comparison of the effects of various sulfhydryl reagents on neuromuscular transmission. PMID- 4317569 TI - [Influence of various steroidal hormones on production of antibody in rabbits]. PMID- 4317570 TI - [ACTH-secreting tumor]. PMID- 4317571 TI - [Erythropoietin producing tumor]. PMID- 4317572 TI - Blood clotting changes in guinea pigs with a heterologous intracranial neoplasm. PMID- 4317573 TI - [Histomorphological considerations of malignant myoblastomyomas and reference to a case involving the maxillo-facial bones]. PMID- 4317574 TI - [Paget's disease of the breast]. PMID- 4317575 TI - [A premature female infant with sepsis of what origin?]. PMID- 4317576 TI - Perinatal regulation of mitochondrial and cytoplasmic enzymes in rabbit liver. PMID- 4317578 TI - [Tonsillitis in children with para-influenza]. PMID- 4317577 TI - [Pathomorphologic changes in the respiratory organs in para-influenza (according to section and experimental data)]. PMID- 4317579 TI - Inhibitory effect of angiotensin on renal sodium reabsorption. PMID- 4317581 TI - Progressive multifocal leukoencephalopathy in chronic lymphatic leukaemia--caused by polyoma virus? PMID- 4317580 TI - [Apropos of an oto-neuro-surgical association]. PMID- 4317582 TI - Free radicals in biological systems. PMID- 4317583 TI - [Fatal case of stomach cancer with a peculiar clinical course]. PMID- 4317584 TI - [Comparative clinical study of acute respiratory virus diseases]. PMID- 4317585 TI - [Basic directions in the prevention of influenza and other respiratory virus infections]. PMID- 4317586 TI - [Prevalence of influenza and other acute respiratory diseases in the USSR and GDR from 1964 to 1967]. PMID- 4317587 TI - [Multiple serologic responses in respiratory virus infections in children]. PMID- 4317588 TI - [New data from experimental study of the etiology of viral hepatitis]. PMID- 4317589 TI - [Changes in serum proteins and serum phosphatases after hypophysectomy and reduced feeding in doves]. PMID- 4317590 TI - [Oral immunization with non living microorganisms or their antigens. 8. Comparing experiments to vaccination by inhalation and nasal, oral, and rectal route]. PMID- 4317591 TI - [Experimental mycoplasma infections in small laboratory animals]. PMID- 4317592 TI - [A lipid from ox brain which inhibits the hemagglutination by TBE virus]. PMID- 4317593 TI - Purification of staphylocoagulase and some of its properties. PMID- 4317594 TI - [The virucidal effect of tannic acid and the eventual application of tannic compounds for the treatment of various virus diseases]. PMID- 4317595 TI - Leukocyte viremia and intrauterine infection. PMID- 4317596 TI - Adrenal blood flow dependence of cortisol secretion rate in unanesthetized dogs. PMID- 4317597 TI - Circadian variation of ether-induced corticosterone secretion in the rat. PMID- 4317598 TI - Brain cholinesterase in grouped and singly caged adrenal-demedullated rats. PMID- 4317599 TI - Hepatic metabolites and cofactors in riboflavin deficiency and calorie restriction. PMID- 4317600 TI - ACTH synthesis and release in pituitary monolayer culture: effect of dexamethasone. PMID- 4317601 TI - Analysis of role of renin-angiotensin system in autoregulation of glomerular filtration. PMID- 4317602 TI - Effects of angiotensin and atropine on plasma free fatty acids. PMID- 4317603 TI - Tests in cushing's syndrome. PMID- 4317604 TI - [Studies of the effect of acute toxaemia with dichlorophenoxyacetic acid on some histochemical reactions of nephrons in the kidney rat cells]. PMID- 4317605 TI - [Histochemical investigations of the liver cells at different times following bilateral vagotomy]. PMID- 4317606 TI - [Histochemical studies of hepatic cells in rats after gonadectomy]. PMID- 4317607 TI - [Pathology and pathogenesis of enzootic bovine leukosis. 3. Light and electron microscopic cytologic studies]. PMID- 4317608 TI - [Suprasegmentary control of the intraspinal pathways of viscero-motor reflexes]. PMID- 4317609 TI - A neuropsychiatric view of insomnia. PMID- 4317610 TI - Effect of general dietary deficiency and protein malnutrition on the fibrogenesis caused by silica dust in rats. PMID- 4317612 TI - Typing of the foot-and-mouth disease virus. Cumulative Quarterly Report. PMID- 4317611 TI - Macular lesions during systemic therapy with depot tetracosactrin. PMID- 4317613 TI - [Typing of the foot-and-mouth disease virus]. PMID- 4317614 TI - [Evolution of the world and regional Monthly epizootic circulars. Animal health status]. PMID- 4317615 TI - [Evolution of the world and regional animal health status. Monthly epizootic circulars]. PMID- 4317616 TI - [Interaction of ACTH with tissue components]. PMID- 4317617 TI - Abolition of the central cardiovascular effects of angiotensin by ablation of the area postrema. PMID- 4317618 TI - [Localization of phosphatases in Clostridium perfringens cells]. PMID- 4317619 TI - The role of cyclic AMP in hepatic and gastrointestinal function. PMID- 4317620 TI - Patients discharged from hospital: an aspect of communication in the Health Service. PMID- 4317622 TI - Aftercare in community mental health centers. PMID- 4317621 TI - [Synthesis of polymyxin D]. PMID- 4317624 TI - Resolution enhancement of ESR spectra from irradiated single crystals of glycine. PMID- 4317623 TI - Neonatal smiling, frowning, and rapid eye movement states. II. Sleep-cycle study. PMID- 4317625 TI - Occurrence of NADH-diaphorases in isolated thymus nuclei. PMID- 4317626 TI - Multiplicity of acid phosphatase catalyzing FMN hydrolysis in spinach leaves. PMID- 4317627 TI - Distribution of orally administered 45Ca in rat intestinal tissues and vitamin D3 effect. PMID- 4317628 TI - [Mucous adenocarcinoma of the urachus]. PMID- 4317629 TI - [Hypophyseal-thyroid-adrenal interactions in man]. PMID- 4317630 TI - [Actinomycetes, a great producer of antibiotics]. PMID- 4317631 TI - [On a case of glomangioma]. PMID- 4317632 TI - [Para-pineal intracranial epidermoid with Parinaud's syndrome]. PMID- 4317634 TI - [Results of treatment of testicular tumors in the Rotterdam Radiotherapeutic Institute]. PMID- 4317633 TI - [Wilm's tumor; preliminary results of the Rotterdam Therapeutic Management, 1965 1969]. PMID- 4317635 TI - Increase of radiation induced leukaemia in C57B1 female mice by infection with mammary tumour virus. PMID- 4317636 TI - [On a test for the choice of antitumoral drugs]. PMID- 4317637 TI - Syndactyly with ipsilateral chest deformity. PMID- 4317638 TI - [A case of surgically treated insulinoma malignum with manifestations of epileptic seizure]. PMID- 4317640 TI - The depersonalizing process the sense of reality and of unreality. PMID- 4317641 TI - [On mammary mucocellular carcinoma. (Anatomopathological, histochemical and clinical study)]. PMID- 4317642 TI - [Cytogenetic studies of a case of Krukenberg tumor secondary to carcinoma of the stomach]. PMID- 4317643 TI - Studies towards a synthesis of phosphatidylinositol. PMID- 4317644 TI - [Results of treatment of urethral cancer in women]. PMID- 4317645 TI - [Some data from a biochemical study of patients with primary cancer of the liver during chemotherapy]. PMID- 4317646 TI - [Contemporary concepts on the nature of the cholinoreceptors]. PMID- 4317647 TI - Pituitary-adrenal relationships in mice with hereditary nephrogenic diabetes insipidus, with special emphasis on the neurohypophysis and pars intermedia. PMID- 4317648 TI - Fine structure of trypsin-dissociated rat adrenal cells. PMID- 4317639 TI - Infectious diseases: annual review of significant publications. PMID- 4317649 TI - Chemical changes in radiation-preserved foods. PMID- 4317650 TI - [Rapidly labelled polyphosphates and metaphosphates in the blue-green alga Anacystis nidulans]. PMID- 4317651 TI - [Comparative action of embryonic and cancerous tissues on the division of Ophyroglena mucifera, infusoria hymenostome histiophage]. PMID- 4317652 TI - [Study of the action of adenosine-cyclic-3'-5'-monophosphate acid on release of growth hormone and prolactin in vitro]. PMID- 4317653 TI - Melanotic ameloblastoma. PMID- 4317655 TI - [Synthesis of highly active corticotropic (1-D-serine,17,18-dilysine)-beta corticotropin-(1-18)-octadecapeptide amide]. PMID- 4317654 TI - [Comparative effects of pure chloramphenicol and chloramphenicol succinate on respiration and glycolysis of rat liver homogenate]. PMID- 4317656 TI - Polyribosomes of the histidine operon in Salmonella typhimurium. PMID- 4317657 TI - Assay and subcellular localization of the arylsulphatases in rat brain. PMID- 4317658 TI - [Polyglobulism associated with primary liver cancer]. PMID- 4317659 TI - [A case of benign hypophosphatasia treated with phosphorus]. PMID- 4317660 TI - [Course of a nephroblastoma and of a sympathoblastoma in an infant]. PMID- 4317661 TI - [Spasmophilia]. PMID- 4317662 TI - [Evaluation of hypothalamo-hypophyseal function which regulates the secretion of ACTH before and after surgery in patients with sellar tumors]. PMID- 4317663 TI - [New therapeutic trials of sulpiride]. PMID- 4317664 TI - Acute intermittent porphyria. PMID- 4317665 TI - [Cell nucleus antigen in virus infection. A contribution to the hepatitis virology]. PMID- 4317666 TI - [Recent findings on the protein structure of the FMD virus]. PMID- 4317667 TI - Acute ethchlorvynol (Placidyl) intoxication. PMID- 4317669 TI - Disseminated intravascular coagulation. PMID- 4317668 TI - Studies on polyol metabolism in Aspergillus niger. 3. Purification and properties of sorbitol dehydrogenase. PMID- 4317670 TI - Clinically evident, non-terminal infections with herpesviruses and the wart virus in immunosuppressed renal allograft recipients. AB - The clinical incidence of herpes simplex lesions, herpes zoster, cytomegalovirus infection, and warts has been determined in a group of renal allograft recipients. Herpes simplex lesions appeared to be no more common after transplantation than before in those patients subject to recurrent attacks. Among 74 patients there were seven cases of herpes zoster and seven serologically proved cases of cytomegalovirus infection with clinical manifestations. The incidence of warts increased with length of time after transplantation, 42% of patients being affected more than one year after transplantation. All of the viral infections studied behaved as in healthy adults, and serious illness, dissemination, wide-spread lesions, and complications were not seen. No factors other than immunosuppression and steroid therapy could be identified with certainty as predisposing to these infections. PMID- 4317671 TI - [Thermal inactivation of NAD-H2-oxidase]. PMID- 4317672 TI - [Pathway of efferent neurons of the auditory cortex in the cat (zones A-I and A IV)]. PMID- 4317673 TI - [Study of free-radical products in the reaction of ninhydrin with amino acids]. PMID- 4317674 TI - [Electron paramagnetic resonance in solutions of oxidized sarcolysin and other antineoplastic agents]. PMID- 4317675 TI - [Morphology of synapses of intramural neurons of the urinary bladder in teleosts]. PMID- 4317676 TI - Acute effect of morphine administration on secretion of adrenal corticosterone in rats. PMID- 4317678 TI - [Purification and immunospecificity of isorenin from the mouse submaxillary gland]. PMID- 4317677 TI - Effect of ACTH on the interconversion of ester and free cholesterol and corticosterone biosynthesis in rat adrenal glands. PMID- 4317679 TI - [Inhibition of yeast alcohol dehydrogenase activity in the presence of germanate and borate]. PMID- 4317680 TI - Direct evidence for 1-electron reduction of molecular oxygen by an enzyme system. PMID- 4317681 TI - A soluble methylene hydroxylase system: structure and role of cytochrome P-450 and iron-sulfur protein components. PMID- 4317682 TI - Possible involvement of cytochrome b5 in L-kynurenine 3-hydroxylase. PMID- 4317683 TI - On the spin state and structure of cytochrome P-450. PMID- 4317684 TI - A possible spectrophotometric assay for a bacterial naphthalene oxygenase. PMID- 4317686 TI - [Cancer of the upper pole of the stomach with osteolytic metastasis of a right rib]. PMID- 4317685 TI - [New type of EPR signal in tumor tissues]. PMID- 4317688 TI - Enhancement of intracerebral infection of mice with Bordetella pertussis. PMID- 4317687 TI - Structure of phosphoprotein metabolically active in phosphorylation and dephosphorylation reactions. PMID- 4317689 TI - Isolation of Bordetella pertussis from pernasal swabs stored in Stuart's transport medium. PMID- 4317690 TI - Intracerebral infection of mice with high-virulence and low-virulence strains of Bordetella pertussis. PMID- 4317691 TI - The growth of viruses in organ-cultures of intestinal epithelium. PMID- 4317692 TI - Effects of dietary supplements and methylene blue on urinary calculi. PMID- 4317693 TI - Fetal renal hamartoma. PMID- 4317694 TI - [Paradoxical sleep and spontaneous potential responses of the skin in kittens and adult cats]. PMID- 4317695 TI - [Prevalence of antibodies against viruses in Cercopithecus aethiops and Macaca irus]. PMID- 4317696 TI - [Chemodectomas simulating tumor of the thyroid gland]. PMID- 4317697 TI - [Functional state of the pituitary-adrenal system in nonspecific ulcerative colitis]. PMID- 4317698 TI - [Insulinoma in aged patients]. PMID- 4317699 TI - [Tracheal hemangiofibroma]. PMID- 4317700 TI - [2 cases of peripheral nervous paralysis due to spontaneous hematoma during anticoagulant therapy]. PMID- 4317702 TI - [Pituitary adenomas. Radiological study of 187 cases]. PMID- 4317701 TI - [Effect of thyroid hormone substitution on length increase and skeletal maturation in children with hypophyseal insufficiency]. PMID- 4317703 TI - More of the same. PMID- 4317704 TI - Enzyme flexibility in Drosophila melanogaster. PMID- 4317705 TI - Clinical and virological studies of acute cerebellar ataxia in childhood. PMID- 4317706 TI - [Histoenzymologic methods in differential diagnosis of benign and malignant tumors in human]. PMID- 4317707 TI - [Neurogenic cervical tumors]. PMID- 4317709 TI - [Modifications of intestinal phosphatase in cirrhosis: hypothesis on physiopathology of its blood retention]. PMID- 4317708 TI - [Energy state of isolated rat liver mitochondria after cessation of prolonged hydrocortisol administration]. PMID- 4317711 TI - The effect of epinephrine and dibutyryl 3',5' cyclic AMP on the incorporation of 32P inorganic phosphate into adenine nucleotides and guanine nucleotides of the intact isolated rat diaphragm. PMID- 4317710 TI - Bartter's syndrome. A report of four cases, including three in one sibship, with comparative histologic evaluation of the juxtaglomerular apparatuses and glomeruli. PMID- 4317712 TI - The effect of heparin and some related agents on diamine oxidase in rabbit blood plasma. PMID- 4317713 TI - Facts and artifacts in gradient centrifugation analysis of catecholamine granules. PMID- 4317714 TI - Urinary oestrogens in ovariectomized cows after administration of ACTH. PMID- 4317715 TI - [Experimental acute pancreatitis in rats and its histopathologic evolution in time. II. Acute pancreatitis induced with different enzymes: trypsin, alphachymotrypsin, elastase, collagenase and lipase]. PMID- 4317716 TI - Observations on the fine structure of Chlamydobotrys stellata, with particular reference to its unusual chloroplast structure. PMID- 4317717 TI - [Borosilicates as the first no carbon containing growth factors]. PMID- 4317719 TI - [Histoenzymatic properties of osteoblastoclastoma]. PMID- 4317720 TI - [Clinico-morphologic characteristics of glomus tumors (chemodectoma) of the middle ear and jugular fossa]. PMID- 4317718 TI - Effect of oligomycin on NADH oxidation and its coupled phosphorylation with the particulate fraction from dark aerobically grown Rhodospirillum rubrum. PMID- 4317721 TI - [Tumor diseases according to autopsy data in Irkutsk for a period of 15 years (1949-1963)]. PMID- 4317723 TI - [ESR study of necroses induced in plant leaves by soil salting]. PMID- 4317722 TI - The oxidation of reduced nicotinamide nucleotides by hydrogen peroside in the presence of lactoperoxidase and thiocyanate, iodide or bromide. AB - Lactoperoxidase (EC 1.11.1.7) catalysed the oxidation of NADH by hydrogen peroxide in the presence of either thiocyanate, iodide or bromide. In the presence of thiocyanate, net oxidation of thiocyanate occurred simultaneously with the oxidation of NADH, but in the presence of iodide or bromide, only the oxidation of NADH occurred to a significant extent. In the presence of thiocyanate or bromide, NADH was oxidized to NAD(+) but in the presence of iodide, an oxidation product with spectral and chemical properties distinct from NAD(+) was formed. Thiocyanate, iodide and bromide appeared to function in the oxidation of NADH by themselves being oxidized to products which in turn oxidized NADH, rather than by activating the enzyme. Iodine, which oxidized NADH non enzymically, appeared to be an intermediate in the oxidation of NADH in the presence of iodide. NADPH was oxidized similarly under the same conditions. An assessment was made of the rates of these oxidation reactions, together with the rates of other lactoperoxidase-catalysed reactions, at physiological concentrations of thiocyanate, iodide and bromide. The results indicated that in milk and saliva the oxidation of thiocyanate to a bacterial inhibitor was likely to predominate over the oxidation of NADH. PMID- 4317724 TI - [Release of catecholamines from the adrenal gland by bradykinin]. PMID- 4317725 TI - [Experimental studies on the endocrine regulation of lipid metabolism by using C14 labeled substances. II. Influence of adrenocortical function on the metabolism of fatty acid and cholesterol]. PMID- 4317726 TI - Detection of specific surface antigens by colony inhibition in cells transformed by papovavirus SV40. PMID- 4317727 TI - In vitro cultivation of the mouse mammary tumor virus: correlation of infectivity and morphology with radioisotope studies. PMID- 4317728 TI - Altered glucose transport kinetics in murine sarcoma virus-transformed BALB-3T3 clones. PMID- 4317729 TI - Comparative studies on distribution of DMBA-3H and 7-hydroxy-DMBA-3H and their carcinogenic activity. PMID- 4317730 TI - Glutamate uptake by a stimulated insect nerve muscle preparation. AB - Recent reports suggest that glutamate may be the excitatory neuromuscular transmitter in insects. In this study, glutamate uptake by isolated cockroach nerve muscle preparations was investigated by means of chemical and electron microscope radioautographic techniques. We found that the preparation had a high affinity for glutamate and that nerve stimulation enhanced glutamate uptake. Chemical studies showed that the average tissue concentration of glutamate bound during a 1 hr incubation period in 10(-5)M glutamate-(3)H after nerve stimulation was 2.8 x 10(-5)M. Less than 1% of the radioactivity was present in the perchloric acid-precipitated protein fraction. Using electron microscope radioautography, we observed that sheath cells showed the highest glutamate concentration of all cellular compartments. Uptake was greater at neuromuscular junctions than in other regions of the tissue. The data suggest a possible mechanism for transmitter inactivation and protection of synapses from high blood glutamate. PMID- 4317732 TI - [Pathology of the peripheral neuropathies of Waldenstrom's disease]. PMID- 4317731 TI - Nuclear membranes from mammalian liver. I. Isolation procedure and general characterization. AB - Nuclear membranes were isolated from rat and pig liver by sonication of highly purified nuclear fractions and subsequent removal of adhering nucleoproteins in a high salt medium. The fractions were examined in the electron microscope by both negative staining and thin sectioning techniques and were found to consist of nuclear envelope fragments of widely varying sizes. Nuclear pore complex constituents still could frequently be recognized. The chemical composition of the nuclear membrane fractions was determined and compared with those of microsomal fractions prepared in parallel. For total nuclei as well as for nuclear membranes and microsomes, various enzyme activities were studied. The results indicate that a similarity exists between both fractions of cytomembranes, nuclear envelope, and endoplasmic reticulum, with respect to their RNA:protein ratio and their content of polar and nonpolar lipids. Both membranous fractions had many proteins in common including some membrane-bound enzymes. Activities in Mg-ATPase and the two examined cytochrome reductases were of the same order of magnitude. The content of cytochrome b(5) as well as of P-450 was markedly lower in the nuclear membranes. The nuclear membranes were found to have a higher buoyant density and to be richer in protein. The glucose-6-phosphatase and Na-K-ATPase activities in the nuclear membrane fraction were very low. In the gel electrophoresis, in addition to many common protein bands, some characteristic ones for either microsomal or nuclear membranous material were detected. Significant small amounts of DNA and RNA were found to remain closely associated with the nuclear envelope fragments. Our findings indicate that nuclear and endoplasmic reticulum membranes which are known to be in morphological continuity have, besides a far-reaching similarity, some characteristic differences. PMID- 4317733 TI - [Neuropathy long before Waldenstrom's disease: effect of prolonged treatment with melphalan]. PMID- 4317734 TI - Some properties of a new epithelial cell line of human origin. PMID- 4317735 TI - Virus production in cultures of simian virus 40-transformed human amnion cells. PMID- 4317736 TI - Mechanism of the development of a stable carrier system of L cells with polyoma virus. PMID- 4317737 TI - Comparison of the effect of the carcinogen N-hydroxy-N-2-fluorenylacetamide in infant and weanling rats. PMID- 4317738 TI - Characteristics of variants of Rous sarcoma virus (RSV) isolated from mouse RSV tumors. PMID- 4317739 TI - [Studies on activities and localization of membrane-bound enzymes in the cell membrane of toad skeletal muscles]. PMID- 4317740 TI - [Nicotinamide-2',3'-dideoxyribofuranosyl-adenine-pyrophosphate]. PMID- 4317741 TI - Cytomegalic inclusion disease in an adult--simulating carcinoma of the pancreas. PMID- 4317742 TI - Concomitant opportunistic infection with toxoplasma pneumocystis and cytomegalovirus. PMID- 4317744 TI - Successful therapy for Wilms' tumor. PMID- 4317743 TI - Radioimmunoassay of anterior pituitary hormones. PMID- 4317745 TI - Problem lesions in adrenal surgery. PMID- 4317746 TI - Prevention of cathetar-induced urinary tract infections and bacteremia. PMID- 4317747 TI - The metabolic and endocrine response to injury. PMID- 4317748 TI - [Changes in the endocrine glands in shock states]. PMID- 4317749 TI - [Use of autoradiography in electron microscopy. 3. Biological applications and final observations]. PMID- 4317750 TI - Studies on the mammary tumor agent (MTA). I. Comparative cytochemistry of nucleic acid and proteins in normal R3f, C57BL mammary glands, and in malignant cells of spontaneous mammary tumors of R3 and virusinduced tumors in C57BL. PMID- 4317751 TI - [Islands of Langerhans in vitro. II. Behavior of histochemically demonstrable enzymes in islands of Langerhans following the cryostat technic and isolation]. PMID- 4317752 TI - [Isodensitometric photography in its histochemical applications]. PMID- 4317753 TI - The use of oral methotrexate (mtx) in the treatment of tumours in the head and neck-region. PMID- 4317754 TI - Summit metabolism in young lambs. Effect of hormones and drugs that affect mobilization and utilization of substrate for cold-induced thermogenesis. PMID- 4317755 TI - Comparison of cryobiological and freeze-drying characteristics of foot and mouth disease virus and of vesicular stomatitis virus. PMID- 4317756 TI - Resolution of some closely related prednisolone derivatives by thin-layer chromatography. PMID- 4317757 TI - Individual variability in antibody response of human volunteers to infection of the upper respiratory tract by coxsackie A21 virus. PMID- 4317758 TI - Establishment of human fetal intestinal organ cultures for growth of viruses. PMID- 4317759 TI - 25-hydroxycholecalciferol. PMID- 4317760 TI - Neonatal herpetic infection. A fatal consequence of penile herpes in a serviceman. PMID- 4317761 TI - [Organic hypoglycemia with prevalent psychic manifestations]. PMID- 4317762 TI - [Neoplastic neuropathy]. PMID- 4317763 TI - [On a case of mucocarcinoma of the vulva]. PMID- 4317764 TI - [Effects of the oral administration of dimethylnitrosoamine in adult rats]. PMID- 4317765 TI - [Granular cell myoblastoma of the gingiva (congenital epilid) with inclusion of epithelial enamel germs]. PMID- 4317766 TI - [Generalized amebiasis in children. Report of 4 cases of cerebral amebiasis]. PMID- 4317767 TI - The technic of percutaneous needle biopsy for diffuse lung disease. PMID- 4317768 TI - Neurosurgery as a part of a comprehensive psychiatric program. PMID- 4317769 TI - Antibiotics in pediatric surgery. PMID- 4317770 TI - Conference on prognosis and insurability of malignant disease. Cancer of the genito-urinary tract. PMID- 4317771 TI - [Linitis plastica of the stomach: 4 cases]. PMID- 4317772 TI - [Interference between measles and poliovirus in the monkey kidney cell culture]. PMID- 4317773 TI - [The fine structure of glycin-induced spheroplasts compared to that of normal bacterial cells of Bordetella pertussis]. PMID- 4317774 TI - [Comparison of the new anaerobic system of Brewer and Allgeier with the method of Koch, tested on pure cultures of clostridia]. PMID- 4317775 TI - [The activity of nicotinic acid hydroxylase and pyrocatechase in chemosensitive mycobacteria and their chemoresistant variants]. PMID- 4317776 TI - [Salivary tumor of the tonsils]. PMID- 4317777 TI - [Reflexions on curietherapy by intra-arterial approach]. PMID- 4317778 TI - [Diesterases in the human skin]. PMID- 4317779 TI - [Extra-mammary Paget's disease. Study of a case by electron microscopy]. PMID- 4317780 TI - Clostridium perfringens panophthalmitis. PMID- 4317781 TI - [Analysis of the EPR spectra of enzymes containing bivalent copper]. PMID- 4317782 TI - [Study of free radicals in gamma-irradiated starch by the electron paramagnetic resonance technic]. PMID- 4317783 TI - [EPR study of non-heme iron complexes in cells and tissues]. PMID- 4317784 TI - [EPR signals of metabolizing mitochondria connected with substrate oxidation and energy accumulation]. PMID- 4317785 TI - [Granulosa cell tumors. Review of the literature and presentation of 7 cases]. PMID- 4317786 TI - [Anti rickets substances in plants. Presence of cholecalciferol]. PMID- 4317787 TI - [The renin-angiotensin system]. PMID- 4317788 TI - Cytogenetic, growth rate and virus susceptibility differences in sublines of H. Ep. 2 cells. PMID- 4317789 TI - Entamoeba histolytica and Dientamoeba fragilis and the syndrome of chronic recurrent intestinal amoebiasis in Israel. PMID- 4317790 TI - Use of the indirect hemagglutination test in some studies of seroepidemiology of amebiasis in the western hemisphere. PMID- 4317791 TI - Tentative method of analysis for manganese content of atmospheric particulate matter. 12132-01-70T. PMID- 4317792 TI - Mmebrane phosphatase and active transport in red cells from different species. PMID- 4317793 TI - Effects of phenethyl alcohol on transport reactions, nucleotide pools and macromolecular synthesis in Novikoff rat hepatoma cells growing in suspension culture. PMID- 4317795 TI - The effects of curare in the cockroach. II. Blockage of nerve impulses by dTC. PMID- 4317794 TI - The effect of altered sodium concentration in the distal nephron segments on renin release. AB - Ethacrynic acid, a potent inhibitor of sodium reabsorption in the ascending limb of Henle's loop, produces a sharp rise in renal venous renin activity within 5 min after intravenous administration in anesthetized dogs. This response persists when volume depletion is prevented by returning urinary outflow to the femoral vein. Comparable studies with chlorothiazide, a diuretic with little or no effect on the medullary portion of the ascending limb of the loop of Henle, failed to produce a significant increase in renal venous renin activity.When administered during ureteral occlusion, ethacrynic acid produced no change in renal venous renin activity until ureteral occlusion was released and flow restored. Following release of the ureters, a prompt rise in renal venous renin was again observed within 5 min of release. Control studies of ureteral occlusion yielded a fall in renal venous renin activity following release of the ureter without administration of ethacrynic acid. These studies identify a prompt stimulatory effect of ethacrynic acid on renin release that is unrelated to volume depletion but dependent upon the presence of tubular urine flow. Although further definition of the site and characteristics of the distal tubular mechanism for stimulation of renin release requires more direct study, the data presented here indicate that changes in sodium concentration in distal tubular fluid serve as a stimulus for renin release. PMID- 4317796 TI - [Effect of the late decapitations on development and activity of the adrenal cortex of chick embryo]. PMID- 4317797 TI - [Phrenic response evoked by stimulation of the parabrachial nucleus in cats]. PMID- 4317798 TI - [Response to A.C.T.H. of the regenerated adrenal gland after neonatal autograft]. PMID- 4317799 TI - [Cortical points in paradoxical sleep]. PMID- 4317800 TI - [Cortical extension of positive-surface waves]. PMID- 4317801 TI - [Relationship between the state of oxidoreduction of cytoplasm NAD and the metabolism of carbohydrates and amino acids in rats treated with hydrocortisone]. PMID- 4317802 TI - [Analysis of eye movements during the paradoxical phase of sleep]. PMID- 4317804 TI - [Experimental analysis of sleep in rats with ventral tegmental injuries]. PMID- 4317803 TI - [Comparative action of the effects of angiotensin and epinephrine on arterial pressure of rats before and after hexamethonium administration]. PMID- 4317806 TI - [Cancer of the Langerhans' islands]. PMID- 4317805 TI - [Selective arteriography in hepatic cancer]. PMID- 4317807 TI - Second golden age of molecular biology. PMID- 4317808 TI - Rous sarcoma virus: a function required for the maintenance of the transformed state. PMID- 4317809 TI - Presence of DNA in Rous sarcoma virus. PMID- 4317811 TI - Jumping on the bandwagon. PMID- 4317810 TI - DNA-directed DNA polymerase activity in oncogenic RNA viruses. PMID- 4317812 TI - [Pituitary and adrenal reserve in circulatory failure]. PMID- 4317813 TI - [Diagnostic value of the angiotensin test]. PMID- 4317814 TI - [Proximal tubular reabsorption of sodium]. PMID- 4317815 TI - [Toward phosphate therapy of bladder stones]. PMID- 4317816 TI - Plasma concentrations of cortisol and corticosterone in the normal horse. PMID- 4317817 TI - Electron microscopy for the rapid diagnosis of pseudocowpox and Milker's nodule. PMID- 4317818 TI - Effect of actinomycin D on synthesis of infectious canine hepatitis virus in canine kidney cell culture. PMID- 4317819 TI - [Response of the human adrenal cortex to corticotropin: potentiation despite the time lapse between 2 stimulations]. PMID- 4317821 TI - [Orbital non-chromaffin paraganglioma]. PMID- 4317820 TI - Photorespiration, Warburg effect and glycolate. PMID- 4317822 TI - [Dermatomyositis with cardiac manifestations and intolerance to iodine]. PMID- 4317824 TI - [Glomus tumor of the eyelid]. PMID- 4317823 TI - Spin-labeled Neurospora mitochondria. AB - Spin-label studies were carried out on Neurospora mitochondria under in vivo and in vitro labeling conditions. A long-chained spin-labeled fatty acid was incorporated by Neurospora and was found in mitochondrial phospholipids. The molecular motion at various temperatures was different from that for the same spin label under in vitro labeling conditions. The results for spin-labeled mitochondria were compared with those from isolated lipids and with those from aggregates of spin-labeled fatty acid and isolated bovine serum albumin. These comparisons suggest that the hydrocarbon portions of membranes are relatively fluid and are not extensively restricted in motion by association with proteins. PMID- 4317825 TI - [Deficiency in retention of conditioning after deprivation of paradoxical sleep in rats]. PMID- 4317826 TI - [Influence of cyclic 3',5'-AMP on the biosynthesis of glycoproteins carriers of corticosteroid hormones]. PMID- 4317827 TI - [Research on correlation between refractory state to the synthesis of interferon and state of antiviral resistance]. PMID- 4317828 TI - [Demonstration of accumulation of infectious nucleocapsids of vesicular stomatitis virus (VSV) in cytoplasm of chick fibroblasts]. PMID- 4317829 TI - [Composition of the colonies of Cubitermes subcrenulatus Silvestri (Isoptera Termitidae)]. PMID- 4317830 TI - [Development of interneuronal connections of an autonomic neuron]. PMID- 4317831 TI - [Effect of radiation on the secretion of adrenocorticotropic hormone by the hypophysis]. PMID- 4317832 TI - [Plausibility of monozygosity in sex-identical twins on the basis of blood group serological findings]. PMID- 4317833 TI - Herpesvirus infection of pigeons. I. Pathology and virus isolation. PMID- 4317834 TI - Herpesvirus infection of pigeons. II. Experimental infection of pigeons and chicks. PMID- 4317835 TI - Occurrence of precipitating antibodies to bovine herpes virus (infectious bovine rhinotracheitis) in sera of farm animals and man in Iran. PMID- 4317836 TI - High glycogen content of red as opposed to white skeletal muscle fibers of guinea pigs. PMID- 4317837 TI - [Biochemistry in anesthesiological field. 5]. PMID- 4317838 TI - Viral tumor induction: importance of sex and route of inoculation. PMID- 4317839 TI - Nicotinamide deficiency and thalidomide: potential teratogenic disturbances in Long-Evans rats. PMID- 4317840 TI - [The effect of magnesium orotate and orotic acid on the enzyme activity of the liver. Experimental studies]. PMID- 4317841 TI - [Adrenal cortex hormones as factors in the treatment of children with infectious hepatitis]. PMID- 4317842 TI - [Cases of multiple stomach cancer associated with islet cell tumor of the pancreas--study of multiple cancer of the stomach and islet cell tumor]. PMID- 4317843 TI - [Proliferative activity of neuroglial tumors]. PMID- 4317844 TI - [Specificity of the fluorometric determination of plasma 11 hydroxycorticosteroids]. PMID- 4317845 TI - [Activity of catechol-ortho-methyltransferase under the influence of angiotensin and during DOCA hypertension in rats]. PMID- 4317846 TI - [A micromethod for the determination of "true" creatinine]. PMID- 4317847 TI - [Technic for the measurement of NADH-consuming enzyme reactions in cerebrospinal fluid]. PMID- 4317848 TI - [Treatment of chemical burns of the esophagus with hormonal preparations]. PMID- 4317849 TI - [The effect of nitrogenous mustard gas (embichin) on the sex cells and embryos of the sea urchin]. PMID- 4317850 TI - [Cell culture changes during transformation]. PMID- 4317851 TI - The characteristics of animal cells transformed in vitro. PMID- 4317852 TI - Epigenetic processes and their relevance to the study of neoplasia. PMID- 4317854 TI - Equine herpesviruses. I. Isolation and characterisation of equine rhinopneumonitis virus and other equine herpesviruses from horses. PMID- 4317853 TI - Univalent cation activation of fructose 1,6-diphosphatase. PMID- 4317855 TI - Preparation of highly labelled (3H)angiotensin II. PMID- 4317856 TI - [Hamster tissue transformation under the influence of simian virus 40 and as a result of prolonged cultivation in vitro]. PMID- 4317857 TI - Studies on the interrelationship between the syntheses of noradrenaline and metaraminol. AB - 1. Experiments were conducted to determine the influence of the rate of noradrenaline synthesis on the conversion of alpha-methyl-m-tyrosine to metaraminol.2. Male Wistar rats, 175-200 g, were placed into four groups and treated with (1) alpha-methyl-p-tyrosine methyl ester, 250 mg/kg; (2) DL-alpha methyl-m-tyrosine, 400 mg/kg; (3) alpha-methyl-p-tyrosine methyl ester, 250 mg/kg plus DL-alpha-methyl-m-tyrosine, 400 mg/kg; or (4) an equivalent volume of injection vehicle. All solutions were injected intraperitoneally.3. Immediately after treatment half of the rats were transferred to 4 degrees C with the remaining animals being kept at 27 degrees C.4. The rats were killed 4, 8 and 12 h after injection, the brains, hearts, spleens and adrenals removed and analysed for adrenaline, noradrenaline, metaraminol and alpha-methyl-m-tyramine.5. In virtually all cases, both during rest (27 degrees C) and sympathetic stress (4 degrees C), treatment of the rats with alpha-methyl-p-tyrosine methyl ester increased the amount of metaraminol formed from alpha-methyl-m-tyrosine. The only organ not containing increased quantities of metaraminol in the presence of alpha methyl-p-tyrosine methyl ester was the adrenals, taken from the rats kept at 27 degrees C. Adrenals removed from the cold-exposed rats contained more metaraminol when alpha-methyl-p-tyrosine methyl ester was combined with alpha-methyl-m tyrosine than when alpha-methyl-m-tyrosine was used alone.6. These results demonstrate that the inhibition of noradrenaline synthesis, by treatment with the tyrosine hydroxylase inhibitor alpha-methyl-p-tyrosine methyl ester, increased the conversion of alpha-methyl-m-tyrosine to metaraminol. It is concluded that inhibiting the formation of dopa allowed increased amounts of alpha-methyl-m tyrosine to enter the biosynthetic pathway. These results support the false sympathetic transmitter concept advanced for metaraminol. PMID- 4317859 TI - Irreversible fixation of increased level of muscle type aldolase activity appearing in rat liver in the early stage of hepatocarcinogenesis. PMID- 4317858 TI - The effect of acute administration of (meta trifluoro methyl-phenyl)-1-(benzoyl oxy) ethyl amino-2-propane (780 SE) and fenfluramine on human sleep. AB - In contrast to other amphetamine derivatives, fenfluramine (40 mg) and 780 SE (300 mg) had no effect on the rapid eye movement (REM) phase of sleep. Like other amphetamines they disturbed sleep, increasing the number of shifts to stage 1 (drowsiness) and stage W (arousal). PMID- 4317860 TI - Pseudo-primary aldosteronism. An entity distinct from true primary aldosteronism. PMID- 4317861 TI - Kinetics of the plasma and lung angiotensin I converting enzymes. PMID- 4317862 TI - High urinary pyrophosphate excretion in the acute phase of pseudogout. PMID- 4317863 TI - On the structure of RNA tumor viruses. PMID- 4317864 TI - Rapid micro procedure for scanning distribution of subcellular components in density gradient fractions of a tissue homogenate. PMID- 4317866 TI - [Biological activity of different zones obtained by ultracentrifugation of the milk factor of the strain PS strain mouse on preformed Ficoll gradients]. PMID- 4317867 TI - Determination of orthophosphate in the presence of inorganic pyrophosphate in the assay of inorganic pyrophosphatase activity. PMID- 4317868 TI - The biochemical mechanism of selective heat sensitivity of cancer cells. 3. Studies on lysosomes. PMID- 4317865 TI - Analysis of orthophosphate-pyrophosphate mixtures resulting from weak pyrophosphatase activities. PMID- 4317869 TI - Collagenolytic activity in synovial fluid cells in rheumatoid arthritis. PMID- 4317870 TI - [Side effects of contraceptive steroids. II]. PMID- 4317871 TI - Effect of change of sodium balance on the corticosteroid response to angiotensin II. PMID- 4317872 TI - Murine disease induced by avian reovirus. PMID- 4317874 TI - Isolation of bradykinin-potentiating peptides from Bothrops jararaca venom. PMID- 4317873 TI - Bio-assay evidence of abnormal secretin-like and gastrin-like activity in tumour and blood in cases of "choleraic diarrhoea". AB - Methods for bio-assay of secretin-like humoral agents in both cat and dog are described. Bio-assay of tumour extracts and of plasma from patients with the pancreatic choleraic syndrome are described. The first patient was found to have choleretic and secretinlike activity in an extract of her pancreatic islet cell tumour and gastrin-like activity in her plasma. The second patient was found to have both secretin and gastrin-like activity in her plasma, as well as choleretic activity. It is concluded that at least part of the profuse, watery electrolyte diarrhoea of the ;pancreatic cholera' syndrome associated with peptide-secreting adenoma of the pancreas is likely to be a reflection of the excessive production of secretin, as well as of gastrin, and possibly also of a choleretic agent. PMID- 4317875 TI - Action of sulfhydryl inhibitors on different forms of the respiratory chain linked reduced nicotinamide-adenine dinucleotide dehydrogenase. PMID- 4317877 TI - Intraoral ulcerations of recurrent herpes simplex and recurrent aphthae: two distinct clinical entities. PMID- 4317876 TI - Effects of catalase inhibitors on the ultrastructure and peroxidase activity of proliferating microbodies. PMID- 4317878 TI - The enzymatic hydroxylation of n-octane by Corynebacterium sp. strain 7E1C. PMID- 4317879 TI - Electromagnetic properties of hemoproteins. 3. Electron paramagnetic resonance characteristics of iron (III) and manganese (II) protoporphyrins IX and their apohemoprotein complexes in high spin states. PMID- 4317880 TI - Stimulation of amino acid transport in rat liver slices by epinephrine, glucagon, and adenosine 3',5'-monophosphate. PMID- 4317881 TI - Growth characteristics of virus-transformed cells. Maximum population density, inhibition by normal cells, serum requirement, growth in soft agar, and xenogeneic transplantability. AB - Virus transformants (like cancer cells, cells transformed by X-ray or carcinogens, or those which have transformed spontaneously) exhibit a number of phenotypic changes which are usually associated, and which may be lost concurrently. That association is, however, not invariable. More particularly, the altered characteristics here studied (escape from contact inhibition of growth and susceptibility to inhibition by other cells, decreased serum requirement, and ability to grow in soft agar) do not, in and of themselves, endow the cell with the capacity to produce a tumor, at least as judged by the methods of assay here used. Although the question as to whether the tumorigenicity of virus transformants is causally linked to any of these associated changes cannot be answered definitively, the evidence suggests a close linkage, rather than identity, between the determinants of oncogenicity and the other properties here studied. PMID- 4317882 TI - Lead and phosphate as sources of artifact in nucleoside phosphatase histochemistry. PMID- 4317883 TI - Frontodigital syndrome: a dominantly inherited disorder with normal intelligence. PMID- 4317884 TI - Encephalitis associated with erythema infectiosum. PMID- 4317885 TI - Parathyroid function in bilharzial (schistomasial) hepatic fibrosis. PMID- 4317886 TI - Diseases of the opossum (Didelphis marsupialis): a review. PMID- 4317887 TI - Vocal cord paralysis. A review of 100 cases. PMID- 4317888 TI - Nasopharyngeal angiofibroma: light and electron microscopic changes after stilbesterol therapy. PMID- 4317889 TI - [Histologically and virologically confirmed Burkitt's in a 10-year-old boy]. PMID- 4317891 TI - [Hybrid cells in medical genetic research]. PMID- 4317890 TI - [Treatment of myotonic dystrophy]. PMID- 4317893 TI - [Andrenocortical insufficiency due to pituitary insufficiency]. PMID- 4317892 TI - [Viral diseases with respiratory and digestive manifestations]. PMID- 4317894 TI - [Steroid-induced adrenal insufficiency]. PMID- 4317895 TI - [Neurologic manifestations of hypoparathyroidism]. PMID- 4317896 TI - Cyclic adenosine monophosphate in bacteria. AB - Both cyclic AMP and a specific inducer acting in concert are required for the synthesis of many inducible enzymes in E. coli. Little enzyme is made in the absence of either. In contrast to the specific inducers which stimulate the synthesis only of the proteins required for their metabolism, cyclic AMP controls the synthesis of many proteins. Glucose and certain other carbohydrates decrease the differential rate of synthesis of inducible enzymes by lowering cyclic AMP concentrations. In the lac operon, cyclic AMP acts at the promoter site to facilitate initiation of transcription. This action requires another protein, the cyclic AMP receptor protein. The nucleotide stimulates tryptophanase synthesis at a translational level. The action of cyclic AMP in E. coli may serve as a model to understand its action on transcriptional and translational processes in eukaryotes. PMID- 4317897 TI - Divergent biological effects of adenosine and dibutyryl adenosine 3',5' monophosphate on the isolated fat cell. AB - Adenosine 3',5'-monophosphate stimulated production of carbon dioxide and lipid from glucose, whereas its dibutyryl derivative inhibited this conversion. Addition of the dibutyryl derivative to the isolated fat cell further stimulated lipolysis induced by adrenocorticotropic hormone, whereas addition of adenosine 3',5'-monophosphate inhibited this lipolysis. Hence, measured by these two parameters, the biologic properties of adenosine 3',5'-monophosphate and its dibutyryl derivative are distinctly different. PMID- 4317898 TI - Biogenesis of vaccinia: separation of early stages from maturation by means of rifampicin. PMID- 4317899 TI - [Thymus pathology in diseases with disturbed immune reactions (review)]. PMID- 4317900 TI - Population kinetics of normal, transforming and neoplastic cell lines. PMID- 4317901 TI - Some characteristics of lipolysis in rabbit adipose tissue. Effects of noradrenaline, ACTH, theophylline and prostaglandin E1. PMID- 4317902 TI - Effect of nicotinic acid on ACTH and noradrenaline stimulated lipolysis in the rabbit. II. In vitro studies including comparison with prostaglandin E1. PMID- 4317904 TI - Biochemical aspects of the interaction of ethanol with barbiturates. PMID- 4317905 TI - [The measurement of nerve conduction velocity and its significance in the diagnosis of neuropathies]. PMID- 4317906 TI - [The clinical significance of plasma renin and angiotensin measurement]. PMID- 4317908 TI - Amino acid substitutions resulting from suppression of nonsense mutations. V. Tryptophan insertion by the Su9 gene, a suppressor of the UGA nonsense triplet. PMID- 4317907 TI - Analysis of sleep in the progressive myoclonus epilepsy. PMID- 4317909 TI - [Organization of pacemaker activites]. PMID- 4317910 TI - [The role of variations of pressive action of exogenic angiotensin in hypotensive action of diuretics. Attempt to determine the role of sodium balance and of natremia of the potassium balance and kalemia and renin activity]. PMID- 4317911 TI - Effects of 25-hydroxycholecalciferol in patients with familial hypophosphatemia and vitamin-D-resistant rickets. PMID- 4317912 TI - A cell-associated factor essential for formation of an infectious form of Rous sarcoma virus. AB - Formation of a specific type of infectious Rous sarcoma virus called RSV(0) has been found to occur only in a certain type of chick embryo cell in the absence of avian leukosis virus. Although these chick cells lack any complete form of avian leukovirus, they appear to carry a genetic factor essential for formation of infectious RSV(0). A factor-deficient cell can be converted to a producer of infectious RSV(0) by infection with Rous sarcoma virus or avian leukosis virus which has been grown in factor-containing cells. Evidence is presented to show that the factor determines both the antigenic and host range specificity of RSV(0). PMID- 4317913 TI - DNA complementary to viral RNA in leukemic cells induced by avian myeloblastosis virus. AB - Nucleic acid hybridization studies were made between 71S-AMV-RNA and DNA from leukemic myeloblasts and from normal chicken cells. There was homology between the viral RNA and chicken cell DNA and to a greater extent between viral RNA and leukemic cell DNA. Leukemic cell DNA hybridized approximately twice as much viral RNA as did normal chicken DNA. Thermal melting studies showed that the viral RNA bound to normal and leukemic cell DNA consists of long polynucleotides (T(m) = 87 degrees and 92 degrees C, respectively, in 2x saline citrate). This suggests that the leukemic cells contain a DNA template of the viral RNA. PMID- 4317914 TI - Leukemia viruses associated with mouse myeloma cells. AB - Myeloma cells derived from BALB/c and C3H mice show evidence of infection by a murine leumemia virus. The immunoglobulin-producing myelomas secrete an RNA containing virus with a density of 1.20 to 1.22 gm/cm(3). RNA with a sedimentation coefficient of 74 S in 0.1 M sodium sodium chloride has been isolated from secreted virus particles and has a base composition similar to that found for other murine leukemia virus RNA. An intracellular virus particle has been partially purified and has a density of 1.29 to 1.32 gm/cm(3). Both extracellular and intracellular virus particles contain the leukemia virus group specific antigen. PMID- 4317915 TI - Membrane structure: lipid-protein interactions in microsomal membranes. AB - The relationships of phospholipid to membrane structure and function were examined in hepatic microsomes. Findings indicate that normal microsomal membrane structure is dependent on lipid-protein interactions and that it correlates closely with glucose-6-phosphatase activity. Modification of most phospholipid with phospholipase-C is associated with widening of the membrane which can be reversed following readdition of phospholipid. PMID- 4317916 TI - Neurally mediated increase in dopamine-beta-hydroxylase activity. AB - The development of a sensitive and specific enzymatic assay for dopamine-beta hydroxylase has enabled us to measure the activity of this enzyme in several tissues where it has previously been measured. The administration of reserpine leads to an increase in dopamine-beta-hydroxylase activity in the rat adrenal, heart, salivary gland, and in sympathetic ganglia. The increase in the heart is preceded by a small but significant fall. We have confirmed the increase in tyrosine hydroxylase which follows the administration of reserpine and have found that the activity of phenylethanolamine-N-methyltransferase also increases after administration of this drug. The activities of two enzymes not involved in the synthesis of catecholamines, monoamine oxidase and lactate dehydrogenase, are not affected by reserpine treatment. The rise of dopamine-beta-hydroxylase activity in the sympathetic ganglia is blocked by surgical decentralization. PMID- 4317917 TI - Interconvertible forms of glycogen phosphorylase in Neurospora crassa. AB - Glycogen phosphorylase in extracts of N. crassa mycelia has two interconvertible forms: one active (a form) and the other inactive (b form) in the absence of 5' AMP. The conversion of the b to the a form requires ATP-Mg(2+) and proceeds at higher rate in the presence of 3',5'-cyclic AMP. PMID- 4317918 TI - Cyclic AMP receptor protein of E. coli: its role in the synthesis of inducible enzymes. AB - A cyclic AMP binding protein has been purified over 100-fold from E. coli extracts. Protein purified from wild-type strains binds cyclic AMP with an apparent dissociation constant of 1-2 x 10(-6)M. Two mutant strains that are unresponsive to exogenous cyclic AMP have altered binding activity; the protein purified from one of these mutants has a decreased affinity for cyclic AMP (apparent dissociation constant = 2 x 10(-5)M). Extracts of this mutant are deficient in their ability to support beta-galactosidase synthesis in vitro. The addition of purified, wild-type binding protein to these extracts restores enzyme synthesis toward normal. Because this binding protein appears to be required for cyclic AMP action, we suggest it be called the cyclic AMP receptor protein (CR protein). PMID- 4317919 TI - Ability of nonenzymic nitration or acetylation of E. coli glutamine synthetase to produce effects analogous to enzymic adenylylation. AB - Treatment of unadenylylated glutamine synthetase from Escherichia coli with tetranitromethane or with N-acetylimidazole produces alterations in catalytic parameters that are similar to alterations caused by the physiologically important process of adenylylation. All three modification reactions lead to a change in divalent ion requirement for biosynthetic activity; the unmodified enzyme requires Mg(2+) for activity, whereas the modified enzymes exhibit increased activity with Mn(2+). The gamma-glutamyl transferase activity of the modified enzyme is more sensitive to feedback inhibition by tryptophan, histidine, CTP, and AMP, and to inhibition by Mg(2+) or to inactivation by 5 M urea. Finally, the pH optimum for the unmodified enzyme is 7.9, while the modified enzymes are more active at pH 6.8. Since treatment of the enzyme with N acetylimidazole results in a decrease in absorbancy at 278 mmu and treatment with tetranitromethane causes an increase in absorbancy at 428 mmu, the effects of these reagents are probably due to modification of certain tyrosyl groups on the enzyme. However, other evidence indicates that the tyrosyl residues which are susceptible to adenylylation in the adenylyltransferase-catalyzed reaction are not involved in the acetylation or nitration reactions. PMID- 4317920 TI - Ribonucleic acid synthesis of vesicular stomatitis virus, II. An RNA polymerase in the virion. AB - The virions of vesicular stomatitis virus contain an enzyme that catalyzes the incorporation of ribonucleotides into RNA. The product of the reaction is mainly RNA complementary in base sequence to that of vesicular stomatitis virus RNA. PMID- 4317921 TI - [Blocking of ACTH release from the pituitary gland with chlorpromazine]. PMID- 4317922 TI - Echinoid skeleton: absence of a collagenous matrix. AB - Lack of hydroxyproline and proline in the calcified distal spines and Aristotle's lantern of the echinoderm Strongylocentrotus indicated the absence of a collagenous matrix. The fact that the small amount of collagen present in the base of the spines and in the test with sutures was removed by bacterial collagenase indicates that this collagen was not calcified. PMID- 4317923 TI - Tilorone hydrochloride: an orally active antiviral agent. AB - Tilorone hydrochloride, 2,7-bis[2-(diethylamino)ethoxy]fluoren-9-one dihydrochloride, given orally to mice before they are infected is active against at least nine viruses of both RNA and DNA groups. The compound is effective when given prophylactically; the optimum time of treatment depends on the route of infection. PMID- 4317924 TI - Tilorone hydrochloride: mode of action. AB - An antiviral serum component is found in mice treated orally with tilorone hydrochloride. The active material fulfills sufficient biological criteria to be classified as an interferon. PMID- 4317925 TI - Enzyme inactivation with ultraviolet laser energy (2650 Angstroms). AB - Inactivation of rat heart lactate dehydrogenase was accomplished by irradiation of the enzyme in solution with a frequency quadrupled neodymium glass laser. PMID- 4317927 TI - Pseudomyxoma peritonei: case report including in vitro mucolysis. PMID- 4317926 TI - Collagenase. PMID- 4317928 TI - Chemotherapy, radiotherapy, and hepatic lobectomy for hepatoblastoma in an infant: report of a survival. PMID- 4317929 TI - Breast cancer in a 10-year-old girl. PMID- 4317930 TI - [Cytostatic treatment of malignant disease in children]. PMID- 4317931 TI - [Criteria of reliability of cytophotometric data]. PMID- 4317932 TI - [Chylous ascites in children. A case of an infant with hepatic and splenic enlargement and simultaneous cytomegalovirus infection]. PMID- 4317933 TI - [Nuclear ribonucleic acids of cancer cells]. PMID- 4317934 TI - [Phosphoproteins and their role in the metabolism of cells]. PMID- 4317935 TI - [Primary glandular cancer of the lungs]. PMID- 4317936 TI - [An experimental-histologic and pathomorphologic study of various soft tissue sarcomas]. PMID- 4317937 TI - [Immunofluorescent and electron microscopic demonstration of virus particles in tissue culture infected by Rous virus]. PMID- 4317938 TI - Inhibition of vasopressor responses by cadmium. PMID- 4317939 TI - Growth curves and the physiology of growth. II. Effects of dietary energy. PMID- 4317940 TI - [Survey on the most common cancers in Iran]. PMID- 4317941 TI - [Cellular surface changes induced by oncogenic viruses and their role in malignant transformation]. PMID- 4317942 TI - [Leukemogenic activity of the mouse radioleukosis virus]. PMID- 4317943 TI - [The role of endogenous interferon in the defense against viral oncogenic diseases. Current status of our experiments]. PMID- 4317944 TI - [Trial of an immunological treatment with tumor extracts irradiated by UV rays in hamster polyoma virus tumors]. PMID- 4317946 TI - Triglyceride synthesis in human subcutaneous adipose tissue cells of different size. PMID- 4317947 TI - The effects of starvation on lipogenesis in human adipose tissue. PMID- 4317945 TI - [Action of vincristine in nephroblastomas]. PMID- 4317948 TI - Carotenoids and fat-soluble vitamins: contribution to food, feed and pharmaceuticals. PMID- 4317949 TI - Content analysis and visual scanning theory in dreams. PMID- 4317950 TI - Adrenal cells in tissue culture: VI. Some additional observations on the effects of nucleotides on steroidogenesis and glycolysis. PMID- 4317951 TI - Crystallographers' progress. PMID- 4317952 TI - Salsolinol, an alkaloid derivative of dopamine formed in vitro during alcohol metabolism. PMID- 4317953 TI - [The radio-isotopic transit in hydrocephalus. Application to indications of ventriculo-cisternostomy and to the control of its effectiveness]. PMID- 4317954 TI - [Active immunotherapy of cerebral tumor. 20 cases]. PMID- 4317955 TI - Metabolism in human amnion. PMID- 4317956 TI - Inhibition of phosphoglucomutase by inorganic pyrophosphate and by adenosine 5' pyrophosphate. PMID- 4317957 TI - The application of angiography to chorionic tumor in following-up its healing process. PMID- 4317958 TI - [Cutaneous glomus and glomangiomas]. PMID- 4317959 TI - [The zoster-varicella association. (Apropos of a clinical case)]. PMID- 4317960 TI - Liver tumors in infants and children. Clinical and pathological analysis of 22 cases. PMID- 4317961 TI - The microcirculatory effects of endotoxin shock as evaluated by effects on interstitial fluid pressure. PMID- 4317962 TI - [Galactorrheas]. PMID- 4317963 TI - Multiple bile-duct hamartomas. PMID- 4317964 TI - Incidence of antibody to EB virus, herpes simplex, and cytomegalovirus in Hodgkin's disease. PMID- 4317966 TI - Ultrastructural studies of an ACTH-secreting thymic tumor. PMID- 4317965 TI - Wilms' tumor: preoperative radiotherapy and chemotherapy in the management of massive tumors. PMID- 4317968 TI - Regulation of arterial pressure in the anephric state. PMID- 4317967 TI - Systemic hemodynamic and myocardial metabolic effects of isoproterenol and angiotensin after open-heart surgery. PMID- 4317969 TI - Ageing, collagen and enzymatic activity in two strains of the laboratory mouse. PMID- 4317970 TI - Bone marrow reactions of young and old rats to chemical stressors. PMID- 4317971 TI - Metabolism of sphingosine bases. XV. Enzymatic degradation of 4t-sphingenine 1 phosphate (sphingosine 1-phosphate) to 2t-hexadecen-1-al and ethanolamine phosphate. PMID- 4317972 TI - [Survey of enterovirus infections in Matsue district, Shimane Prefecture]. PMID- 4317973 TI - [Progress in serological detection of hemolytic streptococcal infections]. PMID- 4317974 TI - [Collagenase activity in the normal stomach, gastric ulcer and cancer in man]. PMID- 4317975 TI - [Histological characteristics and collagenase activities in human gastritis]. PMID- 4317976 TI - [Soluble proteins in cells of Clostridium perfringens]. PMID- 4317977 TI - [Chemodectoma of the lung]. PMID- 4317978 TI - [Effect of poliovirus infection on the intracellular incorporation of choline]. PMID- 4317979 TI - The Texas Cancer Information Service. A proposed statewide service-oriented tumor registry. PMID- 4317980 TI - [Bilateral Wilms' kidney tumors]. PMID- 4317981 TI - [Surgery of adenoma of the hypophysis]. PMID- 4317982 TI - Characteristics of the hydrolysis of 4-phenyl-azobenzyloxycarbonyl-l-prolyl-l leucyl-glycyl-l-prolyl-d-arginine (a collagenase substrate) by enzyme preparations derived from carious dentine. PMID- 4317983 TI - [Viral infections during whooping cough. Preliminary observations]. PMID- 4317985 TI - [Effect of ortho-, para-, prime-dichlordiphenyldichlorethane on the ultrastructure of cells of the anterior pituitary gland in dogs]. PMID- 4317984 TI - Are massive diet fat heart and coronary drug studies justified? A critical commentary. PMID- 4317986 TI - Adrenal tumours and endocrine lesions induced in Syrian hamsters by urethane injected during suckling period. PMID- 4317988 TI - Herpes infection after transplantation. PMID- 4317987 TI - Tissue NAD levels and the response to irradiation of cytotoxic drugs. AB - It has been shown that when (32)P counting from a tumour is continuous peaks in the count rate can sometimes be induced by large doses of nicotinic acid, nicotinic acid, nicotinamide or 3-acetylpyridine, but not by 6-aminonicotinamide. These (32)P counting peaks have been associated with the time of maximal new synthesis of nicotinamide adenine dinucleotide (NAD). Sensitization to irradiation or some cytotoxic drugs has been found at the peak of this new NAD synthesis. The radioprotective agents cysteamine, 2-aminoethylisothiouronium bromide (AET) and serotonin have been found to cause a rapid fall in tissue NAD levels. The results have been briefly discussed. PMID- 4317989 TI - Tarsal-tunnel syndrome is rheumatoid arthritis. PMID- 4317990 TI - Some virological and serological observations on Marek's disease: a preliminary report. PMID- 4317991 TI - The occurrence of antibodies to parainfluenza 3 virus in sera of farm animals and man in Iran. PMID- 4317992 TI - [Inhibitory mechanism of CRF-ACTH system]. PMID- 4317994 TI - [Synthetic ACTH-Z therapy for nephrotic syndrome]. PMID- 4317993 TI - [Application of fluorometeric analysis of unconjugated urinary 11-OHCS as a screening test]. PMID- 4317996 TI - [Effects of Rous virus (Briand strain) on mutations in Drosophila and relation between oncogenesis and mutations]. PMID- 4317995 TI - [The protective action of propylgallate in the radiolysis of aqueous DNA solutions]. PMID- 4317997 TI - Corticosteroids v. corticotrophins with special reference to asthma and rheumatoid arthritis. PMID- 4317999 TI - Comparison of techniques for obtaining the vertex view in brain scanning. PMID- 4317998 TI - [Clinical significance of blood cholinesterase activity in neurologic patients and persons working with organic phosphates]. PMID- 4318000 TI - 3. Secretory tumours of pancreas. Pancreatic tumour associated with life threatening diarrhoea. PMID- 4318001 TI - Islet cell tumours of the pancreas with portal varices and gastrointestinal haemorrhage. PMID- 4318002 TI - [Osteopetrosis gallinarum, a disease sui generis accompanying virus dependent tumors and hyperplasia in birds]. PMID- 4318003 TI - [Use of iodamide (Uromiro) in urographic study]. PMID- 4318004 TI - Modern views on physiology. II. The regulation of arterial blood pressure. PMID- 4318005 TI - [Isolation and identification of pyridine nucleotides]. PMID- 4318006 TI - Electron spin resonance studies of irradiated nucleic acid and nucleic acid cysteamine systems. PMID- 4318007 TI - [The reflex of the celiac plexus]. PMID- 4318008 TI - [The state of water-salt metabolism in patients with eosinophilic adenomas of the hypophysis]. PMID- 4318009 TI - Severe illnesses due to adenovirus type 7 in children. PMID- 4318010 TI - [Toxic epidermal necrolysis]. PMID- 4318011 TI - Perfusion brain scans and the anatomic lesions encountered: a correlation. PMID- 4318012 TI - Serial brain scanning with radioactive xenon and scintillation camera. PMID- 4318013 TI - Sr85m scans in children with extraosseous pathology. PMID- 4318014 TI - Rates of aminoacyl-transfer-ribonucleic acid synthesis in vivo and in vitro by bean leaves. AB - 1. A procedure for measuring rates of aminoacyl-tRNA synthesis in vitro and in intact leaves is presented. 2. Leaf discs showed rates close to those of intact leaves. 3. Cell-free preparations showed similar rates when assayed by pyrophosphate exchange, but actual aminoacyl-tRNA formation rates appeared to be much lower. Evidence is presented that dilution of supplied labelled amino acids was a major factor causing the low apparent rates. 4. Attempts to strip endogenous amino acids from plant tRNA resulted in low acceptor capability of the tRNA. PMID- 4318015 TI - The isolation by isopycnic density-gradient centrifugation of two mitochondrial populations from livers of embryonic and fed and starved adult rats. AB - 1. Mitochondria isolated from livers of fed adult, starved adult, and embryonic rats can be separated into three distinct bands by isopycnic density centrifugation on a sucrose density gradient. The least dense band (B1) has a mean buoyant density of 1.162 and consists mainly of disrupted mitochondria. The middle band (B2) has a mean buoyant density of 1.184. The most dense band (B3) has a mean buoyant density of 1.216. B2 and B3 consist of intact mitochondria. 2. The mitochondria in B2 and B3 have very similar protein/phospholipid ratios, virtually identical phospholipid and fatty acid compositions and similar specific activities for cytochrome oxidase, malate dehydrogenase and monoamine oxidase. Both fractions have very low glucose 6-phosphatase and acid phosphatase activities. 3. As isolated, adult rat liver mitochondria have electron-dense matrices (condensed forms); some embryonic liver mitochondria are condensed, but a significant proportion have dilated matrices. All B2 mitochondria are in the condensed form. B3 mitochondria from adult rats are condensed if fixed in their equilibrium-density sucrose, but when this is diluted rapidly to 0.25m they become swollen. Some B3 mitochondria from embryonic rats are condensed, the others have dilated matrices. They all swell if rapidly diluted to 0.25m-sucrose. B2 mitochondria retain their condensed form on dilution of the sucrose. 4. It is concluded that the matrix space of B2 mitochondria is almost totally inaccessible to sucrose, but that of B3 mitochondria is readily accessible to sucrose. 5. In liver from normally fed adult rats the B2 mitochondria predominate, whereas in starved rats B2 and B3 are present in approximately equal proportions. Mitochondrial preparations from embryonic liver consist predominantly of B3 mitochondria, but the proportion of these decreases progressively as development proceeds. 6. The B2 mitochondria from livers of fed adult rats can be converted into B3 mitochondria by incubation with 10mm-succinate and 10mm-phosphate. 7. Some B2 mitochondria are converted into B3 mitochondria by exposure to high concentrations of sucrose. PMID- 4318016 TI - Mescaline-induced changes of brain-cortex ribosomes. Effect of mescaline on the stability of brain-cortex ribosomes. AB - 1. During the action of mescaline sulphate on goat brain-cortex slices the ribosomal particles become susceptible to breakdown, releasing protein, RNA, acidsoluble nucleotides and ninhydrin-positive materials, resulting in loss of ribosomal enzyme activities. 2. Ribosomes of the mescaline-treated cortex slices undergo rapid degradation in the presence of trypsin and ribonuclease. 3. Mescaline does not alter the chemical and nucleotide compositions or the u.v. absorption characteristics of ribosomal particles, however. PMID- 4318017 TI - A simple spot screening test for fast detection of red cell NADH-diaphorase deficiency. PMID- 4318018 TI - Leukemia in Fanconi's anemia: cytogenetic and tumor virus susceptibility studies. PMID- 4318019 TI - Sleeping pills. PMID- 4318021 TI - Home from hospital. PMID- 4318022 TI - Foreign-body reaction to an industrial polishing agent containing silicate. PMID- 4318020 TI - Sleep and hypnotics: further experiments. AB - Two experiments compatible with that used to investigate the effect of clinical doses (200 mg.) of amylobarbitone were set up to investigate the effects of clinical doses of chloral hydrate (800 mg.), dichloral phenazone (1,300 mg.), and Mandrax (methaqualone 250 mg. and diphenhydramine 25 mg.) over a period of one to two weeks.Four healthy male subjects were used in each experiment and received placebo or drug throughout a period of six to eight weeks when control records, drug records, and drug withdrawal records were obtained.Chloral hydrate was found to depress rapid eye movement (R.E.M.) sleep appreciably though less consistently than amylobarbitone. No withdrawal R.E.M. sleep rebound was found.Neither dichloralphenazone nor Mandrax was found consistently to depress R.E.M. sleep, though occasional nights when R.E.M. sleep was low occurred more often with Mandrax.In the light of other experiments it is postulated that there exists a "threshold" in the dose of a hypnotic, and that when this is exceeded the drug will produce R.E.M. reduction. Thus it may be possible to prescribe a drug which is clinically useful while avoiding withdrawal effects. PMID- 4318023 TI - Quantitative evaluation of irradiated bone grafts resorption rate by the electron spin resonance technic. PMID- 4318024 TI - The ultrastructural localization of the G-6-P hydrolyzing enzyme activity in Kupffer cells. PMID- 4318025 TI - [Cold as trigger of glycogen storage during oogenesis of Musca domestica]. PMID- 4318026 TI - Acquisition of an embryonal biochemical feature by rat hepatomas. PMID- 4318027 TI - Sedimentation behaviour of the avian tumor virus group specific antigen from the BAI strain, a virus associated myeloblast cell. PMID- 4318028 TI - Neurological disorders and adult coeliac disease. AB - An investigation into the incidence of neurological disorder in 30 patients with adult coeliac disease has shown that three patients had severe depression, two had epileptiform convulsions, and one patient only had signs of involvement of the peripheral nervous system. Motor nerve conduction velocity was low in only one patient. When the nerve conduction velocities of the group on a gluten-free diet were compared with the group who were not on a gluten-free diet, there was no statistically significant difference. Similarly, nerve conduction velocities in patients with a low serum pyridoxal level were not significantly different from those with normal serum pyridoxal levels. Measurements of the serum level of pyridoxal in 30 patients confirmed that pyridoxine deficiency occurs in adult coeliac disease and that the restriction of gluten from the diet appeared to affect pyridoxal levels favourably. PMID- 4318029 TI - Reduced adjuvant activity of Bordetella pertussis vaccine in mice after priming with an immunogenic threshold dose. PMID- 4318030 TI - [Polyvinypyridine-N-oxide and the development of silicosis in rats following inhalation of quartz dust from a steel casting cleaning plant]. PMID- 4318031 TI - Carcinogenesis by RNA sarcoma viruses. XIV. Infection of stationary cultures with murine sarcoma virus (Harvey). PMID- 4318032 TI - Histochemical study on rat liver glycogen during DAB carcinogenesis. PMID- 4318033 TI - The effects of some metabolic inhibitors on the ability of SV40 virus in transformed cells to be detected by cell fusion. PMID- 4318034 TI - Sclerosing angioma of pinna. PMID- 4318035 TI - Effect of adrenocorticotrophic hormone on urinary oestrogens and vaginal epithelium in ovariectomized patients. PMID- 4318036 TI - Separation of Sendai virus protein by thin layer polyacrylamide gel electrophoresis. PMID- 4318037 TI - Brain tumors induced with Rous sarcoma virus, Schmidt-Ruppin strain. 2. Rous tumor specific transplantation antigen in subcutaneously passaged mouse brain tumors. PMID- 4318038 TI - [Mechanism of insulin secretion--with special consideration of prediabetes]. PMID- 4318039 TI - [Multiple sclerosis. 6. Treatment with steroids]. PMID- 4318040 TI - [Primary carcinoma of the liver: importance of paraneoplasic signs]. PMID- 4318041 TI - A new look at the ocular side-effects of long-term systemic corticosteroid and adrenocorticotrophic therapy. PMID- 4318042 TI - New thoughts on immunization programmes in general practice. PMID- 4318043 TI - [Isotopic exploration of nucleic acid synthesis from 2 human liver epitheliomas]. PMID- 4318044 TI - [Various physiological aspects of sleep]. PMID- 4318045 TI - [Canal neuropathy of the subscapular nerve]. PMID- 4318046 TI - [Fatal bronchopneumonia and encephalitis in adenovirus infection]. PMID- 4318047 TI - Ampicillin levels in sputum, serum, and saliva. PMID- 4318048 TI - Effect of different doses of prednisolone and adrenocorticotrophic hormone (acth) on lymphatic lung clearance and on experimental silicosis. A study in rats. PMID- 4318049 TI - Electrophoretic separation of hormones associated with secretory granules from rat anterior pituitary glands. PMID- 4318050 TI - [Buffer action of limbic-hypothalamus system to stress: an observation on adrenocortical hormones]. PMID- 4318052 TI - Thin-layer chromatography of steroidal pharmaceuticals. PMID- 4318053 TI - Separation and gas chromatographic determination of normal hydrocarbons in tobacco leaves. PMID- 4318054 TI - [On the velocity of propagation of the rheographic wave in the extremities during intravenous infusion of angiotensin II in normal subjects]. PMID- 4318051 TI - Susceptibility of Enterobacter aerogenes and Enterobacter cloacae to 19 antimicrobial agents in vitro. PMID- 4318055 TI - [Changes in the systolic phases of the left ventricular mechanical cycle induced by administration of angiotensin II in intravenous infusion in normal subjects]. PMID- 4318056 TI - [The application of the method of paramagnetic probe in the study of membranes of cellular organels]. PMID- 4318058 TI - Chromosome studies in glial tumours. PMID- 4318057 TI - [Necrolytic therapy in deep thermal burns]. PMID- 4318059 TI - [On clones deriving from cellular line chronically infected with Rauscher virus]. PMID- 4318060 TI - The covalent binding of metabolites of tritiated 2-methyl-4-dimethylamino azobenzene to rat liver nucleic acids and proteins, and the carcinogenicity of the unlabelled compound in partially hepatectomised rats. PMID- 4318061 TI - [On the detection in renal cancers of an antigen not found in normal human kidney]. PMID- 4318062 TI - The effect of thioacetamide on the embryonic rat liver and hepatoma cells. PMID- 4318063 TI - Studies on the mechanism of action of 2,3,5-triethylenimino-1, 4-benzoquinone ("Trenimon" Bayer). PMID- 4318064 TI - Histochemical characteristics of giant cell bone tumours. PMID- 4318065 TI - Some histochemical renal changes in mice during acute poisoning with benzene. PMID- 4318066 TI - Mucopolysaccharide histochemistry of Musca domestica. II. The peritrophic membrane. PMID- 4318067 TI - The problem of in vivo transport of molecular oxygen through the mitochondrial membranes. PMID- 4318068 TI - [Influence of adrenalectomy on liver glycogen and blood glucose in rats---with special reference to the effects of formalin, cortisone and ACTH]. PMID- 4318069 TI - An experimental study on the effect of blood or blood component transfusion to the transplanted tumor cells. PMID- 4318070 TI - Metastases occurring after excision of a transplantable subcutaneous hepatoma. PMID- 4318071 TI - Antiviral phenoxathiins and their analogs. Study of the structure-activity relationships for antiviral activity and the replacement ability in poliovirus type 3 dependent variants. PMID- 4318073 TI - Angiotensin II analogs. IV. Synthesis and biological evaluation of simplified angiotensins. PMID- 4318072 TI - Neuraminidase inhibition and viral chemotherapy. PMID- 4318074 TI - Synthesis and endocrine activity of some 3-aza-A-homopregnenes. PMID- 4318075 TI - Biological characteristics of cell line GL-V3 derived from the kidney of a vervet monkey (Cercopithecus aethiops). PMID- 4318076 TI - The influence of mycoplasma infection on the sensitivity of HeLa cells for growth of viruses. PMID- 4318077 TI - The specificity of rabbit antisera to Herpesvirus hominis and its dependence on the dose of virus inoculated. PMID- 4318078 TI - Some cultural reactions of Clostridium tetani. PMID- 4318079 TI - Differentiation of actively and passively acquired complement-fixing antibodies in infants with respiratory syncytial virus infection. PMID- 4318080 TI - The antiviral activity of isoquinoline drugs for rhinoviruses in vitro and in vivo. PMID- 4318082 TI - Reciprocal environmental surveillance model of sleep. PMID- 4318083 TI - Isolation of two plaque variants from the adenovirus type 2-simian virus 40 hybrid population which differ in their efficiency in yielding simian virus 40. AB - Studies on the adenovirus type 2-simian virus 40 (SV40) hybrid population demonstrated two genetically stable variants within this population, which were isolated by plaquing in African green monkey kidney cells. These variants were similar in that each induced SV40 T antigen in human embryonic kidney cells and contained similar concentrations of nonhybrid adenovirus type 2 virions and adenovirus-encapsidated particles containing the infectious SV40 genome. These variants differed markedly, however, in their ability to produce SV40 viral antigen in human embryonic kidney cells and the efficiency with which they produce SV40 plaques in monkey cell monolayers. It is postulated that the differences in SV40-yielding efficiency between these variants lie in the nature of the recombinant deoxyribonucleic acid composing the genome of the hybrid particles. PMID- 4318085 TI - Focus formation by a murine sarcoma leukemia virus complex. I. Theoretical analysis. AB - The transformation of cells in culture by a murine sarcoma-leukemia virus complex leads to the formation of identifiable foci. Titration patterns of focus counts vs. virus dilutions have been explained as being due to the interactions of three virions: leukemia, defective sarcoma, and competent hybrid. This interaction is analyzed quantitatively and equations are derived which permit determination of the composition of a sarcoma virus pseudotype as well as use of the technique for the assay of exogeneous leukemia virus. The analysis is based on the statistical distribution of virions in the culture cells and assumes that all virions have equal probability of infecting a cell and that transformation of any one cell will lead to focus formation. Limitations of the assumptions and expected measurement accuracy are discussed. PMID- 4318084 TI - Equilibrium density gradient studies on simian virus 40-yielding variants of the adenovirus type 2-simian virus 40 hybrid population. AB - The simian virus 40 (SV40)-yielding variants of the adenovirus type 2 (Ad.2)-SV40 hybrid (Ad.2(++)) population were studied by means of fixed-angle equilibrium density gradient centrifugation in cesium chloride. The hybrid virions of the Ad.2(++) high-efficiency yielder population banded at densities of 0.004 g/cm(3) lighter than the nonhybrid Ad.2 virions. The degree of separation of the hybrid particles was sufficient to permit greater than 100-fold relative purification by two cycles of centrifugation. Hybrid particles that produce adenovirus plaques in African green monkey kidney cells by two-hit kinetics (one-hit kinetics when assayed on lawns of nonhybrid adenovirus) were not separable from the particles that yield SV40 virus. The hybrid particle in the Ad.2(++) low-efficiency yielder population was not separable from the nonhybrid Ad.2 virions. PMID- 4318086 TI - Focus formation by a murine sarcoma leukemia virus complex. II. Quantitative aspects of the interaction between radiation leukemia virus and its murine sarcoma virus pseudotype in strain C57BL mouse embryo cells. AB - A quantitative study has been made of the interactions between radiation leukemia virus (RadLV), its murine sarcoma virus pseudotype, and their C57BL host cells. The elimination of interference phenomena by delayed infection of cells with RadLV made possible the quantitative determination of the pseudotype in terms of defective sarcoma and endogenous RadLV particles. This in turn permitted the quantitative assessment of RadLV helper activity and of the various factors which influence the accuracy and sensitivity of the helper assay. PMID- 4318087 TI - Deoxyribonucleic acid replication in simian virus 40-infected cells. II. Detection and characterization of simian virus 40 pseudovirions. AB - Purified simian virus 40 (SV40) virions, grown in primary African green monkey kidney cells labeled prior to infection with (3)H-thymidine, contain a variable quantity of (3)H-labeled deoxyribonucleic acid (DNA). This DNA is resistant to deoxyribonuclease, sediments at 250S, and is enclosed in a particle that can be precipitated with SV40-specific antiserum. DNA-DNA hybridization experiments demonstrate that this (3)H-labeled component in purified SV40 virions is cellular DNA. When this (3)H-labeled DNA is released from purified virus with sodium dodecyl sulfate, it has an average sedimentation constant of 14S. Sedimentation through neutral and alkaline sucrose gradients shows that this 14S DNA is composed of a collection of different sizes of DNA molecules that sediment between 11 and 15S. As a result of this size heterogeneity, SV40 virions containing cellular DNA (pseudovirions) have a variable DNA to capsid protein ratio and exhibit a spectrum of buoyant densities in a CsCl equilibrium gradient. Pseudovirions are enriched, relative to true virions, on the lighter density side of infectious SV40 virus banded to equilibrium in a CsCl gradient. Little or no cellular DNA was found in purified SV40 virus preparations grown in BSC-1 or CV-1 cells. PMID- 4318088 TI - Foot-and-mouth disease virus-induced alterations of baby hamster kidney cell macromolecular biosynthesis: inhibition of ribonucleic acid methylation and stimulation of ribonucleic acid synthesis. AB - The kinetics of ribonucleic acid (RNA) and protein synthesis and RNA methylation were examined after foot-and-mouth disease virus (FMDV) infection of baby hamster kidney cells. The synthesis of RNA extracted from the whole cells was stimulated two- to threefold above the control level of synthesis. This increased rate was attributed to viral RNA synthesis. The inhibition of host RNA methylation was concomitant with but more pronounced than protein synthesis inhibition. The methylation of transfer RNA was initially inhibited by virus infection, but rose to within 70 to 80% of the control level just prior to the production of maximal amounts of virus-specific RNA polymerase. Cycloheximide studies showed that rapid cessation of protein synthesis did not result in the immediate cessation of RNA methylation. A comparison between the kinetics of inhibition of these processes by cycloheximide and FMDV infection suggests that FMDV selectively inhibits RNA methylation. PMID- 4318089 TI - Mechanism of oncogenic transformation by Rous sarcoma virus. I. Intracellular inactivation of cell-transforming ability of Rous sarcoma virus by 5 bromodeoxyuridine and light. AB - Chick embryo fibroblasts brought into stationary phase of growth by maintenance in serum-free Eagle's MEM medium were infected with the Bryan strain of Rous sarcoma virus (B-RSV) and incubated for 18 hr in the presence of 5-bromo deoxyuridine (BUdR). The cells were then allowed to resume growth and deoxyribonucleic acid (DNA) synthesis by addition of an enriched F12 medium containing serum and RSV antibody to prevent spread of viral infection. After 48 hr, the cultures were exposed for various periods to visible light, overlaid with solid culture medium, and observed for the appearance of foci of transformed cells. In cultures treated with BUdR at the time of infection, exposure to light resulted in a suppression of focus formation of from 50 to 90% in various experiments. Treatment with BUdR for 18 hr before infection or on the day after infection, followed by exposure to light, had no effect on focus formation. In cultures in which almost all cells were infected, treatment with BUdR followed by exposure to light did not result in cell death. This suggests that suppression of transformation is not due to selective killing of infected cells by this treatment but rather to the intracellular inactivation of the transforming ability of Rous sarcoma proviral DNA. PMID- 4318091 TI - Synergistic action of sodium and angiotensin on brain mechanisms controlling fluid balance. PMID- 4318090 TI - Biophysical comparison of two canine adenoviruses. AB - The two canine adenoviruses, infectious canine hepatitis (ICH) virus and infectious canine laryngotracheitis (ICL) virus (also designated as Toronto A26/61 virus), were studied with respect to their morphology and the biological properties of their soluble components. The two viruses were found to be composed of soluble components similar to, and carrying biological activities corresponding to, those of the human adenoviruses after fractionation by rate zonal centrifugation and anion-exchange chromatography. The following soluble components were identified: hexons (carrying a common group-specific complement fixing antigen), penton oligomers (complete soluble hemagglutinin), and penton and fiber monomers (incomplete soluble hemagglutinins). The latter were indicated by hemagglutination enhancement with selected antisera directed against human adenovirus soluble components. Elution characteristics of corresponding components of the two viruses in anion-exchange chromatography experiments were distinctly different. Electron microscopic examination of purified virions and soluble components revealed the fiber component of ICL virus to be 35 to 37 nm in length, and that of ICH virus to be 25 to 27 nm long. PMID- 4318092 TI - Improvements in the isolation of noradrenaline storage vesicles from bovine splenic nerves. PMID- 4318093 TI - The effect of angiotension on the turnover rate of norepinephrine in the rat heart. PMID- 4318095 TI - Tumors, hormones, and viruses in Drosophila. PMID- 4318094 TI - Aflatoxicosis in coho salmon. PMID- 4318096 TI - [Some cases of "epulis" from Cameroon]. PMID- 4318097 TI - [Malignant synovioma of the thoracic wall]. PMID- 4318098 TI - [Detergents as a factor modifying the surface of crystalline silica]. PMID- 4318099 TI - [Experimental evaluation of the toxicity of the 3,3'-dichlor-5, 5'-dinitro-o-o diphenol (Distolone). I. Changes in the activity of some enzymes in blood serum]. PMID- 4318100 TI - Differential adrenocortical stress responses in naval aviators during aircraft carrier landing practice. PMID- 4318101 TI - [Lupoid polyneuropathy. Clinical case]. PMID- 4318102 TI - [The role of viruses in the origin of neoplasms]. PMID- 4318103 TI - [A poliomyelitis epidemic caused by poliovirus type 3 in the region of Poznan in 1968. Preliminary communication]. PMID- 4318104 TI - Comparison between antibodies to bovine and human thyrotrophin (TSH) for radioimmunoassay in plasma: cross reaction studies with clinical results. PMID- 4318105 TI - Effects of aminoglutethimide in a case of ectopic ACTH syndrome. Influence on steroid metabolism. PMID- 4318106 TI - [The fatty acids in experimental encephalopathy caused by cyanides]. PMID- 4318107 TI - [Cytometric study of the cells of cerebral tumors]. PMID- 4318108 TI - Interference of ethidium bromide with the replication of herpes virus DNA. Brief report. PMID- 4318109 TI - The role of the thymus in antibody production and in resistance to Japanese encephalitis virus infection. PMID- 4318110 TI - Growth studies of parainfluenza virus (type 2). PMID- 4318111 TI - Attenuation of foot-and-mouth disease virus by chemical means. PMID- 4318112 TI - High mutation rate of foot-and-mouth disease virus treated with hydroxylamine. PMID- 4318113 TI - Pigmented variants of Rhizobium. Isolation, genetical constitution, heat- and U.V.-resistance. PMID- 4318114 TI - Investigation of protein hydration by proton spin relaxation time measurements. PMID- 4318115 TI - Electron spin resonance identification of melanin in comedones. PMID- 4318116 TI - Artificial rearing of pigs. 1. Effect of frequency and level of feeding on performance and digestion of mk proteins. PMID- 4318117 TI - Studies on the biochemical properties of surface component of normal and SV-40 transformed 3T3 mouse cells. PMID- 4318118 TI - Biosynthesis of linear furanocoumarins. PMID- 4318119 TI - Circular dichroism studies on Mengo virus variants and their constituent ribonucleates. PMID- 4318120 TI - [On primary tumors of the umbilical area (neoplasms deriving from the omphalouracho-allantoid complex)]. PMID- 4318121 TI - Evidence for the renal conversion of angiotensin I in the dog. PMID- 4318122 TI - Poland's syndrome. PMID- 4318123 TI - Studies on the glycolipids and phospholipids of immature soybeans. PMID- 4318124 TI - Comparative autoxidative susceptibility of fatty esters with O-6 methylene interrupted double bonds. PMID- 4318125 TI - [Present chemical composition of commercial trielenes and their hepatotoxic effects. Clinical and enzymological study]. PMID- 4318126 TI - Unique glycoprotein from mouse milk containing the mammary tumour agent. PMID- 4318128 TI - Variability, structural glycoproteins, and classification of herpes simplex viruses. PMID- 4318127 TI - Differential toxicity on normal and transformed cells in vitro and inhibition of tumour development in vivo by concanavalin A. PMID- 4318129 TI - Renal prostaglandins: possible regulators of the renal actions of pressor hormones. PMID- 4318130 TI - Specific ion electrode in the determination of urinary fluoride. PMID- 4318131 TI - [Frey's syndrome (auriculotemporal syndrome)]. PMID- 4318132 TI - The effect of prostigmin on the basal electromyogram in myasthenia. PMID- 4318133 TI - Painful forefoot from glomus tumor. PMID- 4318134 TI - [The pulmonary lymphatic system of the rat following experimental exposure to quartz dust]. PMID- 4318136 TI - [Unusual metastatic involvement of the spleen by mammary carcinoma]. PMID- 4318137 TI - Alterations in the fine structure of cytoplasmic organelles in the hepatopancreatic cells of shell-regenerating snail, Helix pomatia L. PMID- 4318138 TI - Studies on the ultrastructure and histochemistry of the bulbourethral gland in the goat. PMID- 4318139 TI - Adrenocortical function in the aged, assessed by the rapid corticotrophin test (Synacthen). PMID- 4318140 TI - Pituitary-adrenal function in old age evaluated by the intravenous metyrapone test. PMID- 4318141 TI - Plasma angiotensin II and aldosterone excretion during the menstrual cycle. PMID- 4318142 TI - [Possible sources of error in the determination of respiration of tissue slices]. PMID- 4318143 TI - The response of isolated arteries and veins to potassium, osmolarity and drugs. PMID- 4318144 TI - Plasma renin level in hepatic cirrhosis. Relaton to functional renal failure. PMID- 4318145 TI - Virilization during pregnancy. Case report and review of literature. PMID- 4318146 TI - Fractionation of chick embryo cell RNA on columns of poly-L-lysine coated kieselguhr. PMID- 4318147 TI - Isolation of DNA satellites by thermal chromatography in the presence of sodium perchlorate. PMID- 4318148 TI - Preparation of stable p-chloromercuribenzoate solutions. PMID- 4318149 TI - Hypnotics and altered sleep-dream patterns. I. All-night EEG studies of glutethimide, methyprylon, and pentobarbital. PMID- 4318150 TI - Hypnotics and altered sleep-dream patterns. II. All-night EEG studies of chloral hydrate, flurazepam, and methaqualone. PMID- 4318151 TI - Hypnotic drugs and their effectiveness. All-night EEG studies of insomniac subjects. PMID- 4318152 TI - [Immunological studies of tumors]. PMID- 4318153 TI - Kinetics of the protection of lactate dehydrogenase by substrates against heat inactivation. PMID- 4318154 TI - Purification and properties of a NAD-dependent glutamate dehydrogenase from Clostridium SB4. PMID- 4318155 TI - Studies on the allosteric activation of glycogen phosphorylase b by nucleotides. II. Nucleotide structure in relation to mechanism of activation. PMID- 4318156 TI - Purification and properties of leaf ribonuclease from sugar cane. PMID- 4318157 TI - Menadione reductase from Desulfovibrio gigas. PMID- 4318158 TI - [Presence of virus particles in organs of the NZB mouse]. PMID- 4318159 TI - [Brain tumours in geriatric patients]. PMID- 4318160 TI - [A method of detecting atypical cells in the blood of lung cancer patients]. PMID- 4318161 TI - [The effect of adrenocorticotropic hormone, adrenal gland hormone preparations and adrenalectomy on the course and outcome of dicaine poisoning in mice]. PMID- 4318162 TI - An electron spin resonance study of tobacco smoke condensates and their effects upon blood constituents. PMID- 4318163 TI - A simplified technique for stack dispersion mapping with tritium. PMID- 4318164 TI - [Localization of the effect of narcotic analgesics in the spinal cord]. PMID- 4318165 TI - [Comparative sensitivity of neuromuscular synapses of different muscles toward diadonium and decadonium]. PMID- 4318166 TI - [Study of antiviral properties of Calendula officinalis]. PMID- 4318167 TI - [Treatment of atrophic rhinitis]. PMID- 4318168 TI - [Findings of aflatoxins in food rations and hepatoma incidence in mice]. PMID- 4318170 TI - [Theoretical and practical value of some enzymatic determinations during the course of pleural effusions (amylase, phosphatases, lactate dehydrogenases). 129 observations]. PMID- 4318169 TI - Stimulation of amino acid incorporation into protein in vitro by various nuclear RNA fractions of the AH-130 hepatoma cells. PMID- 4318171 TI - Voltage threshold in excitable cells depends on stimulus form. PMID- 4318172 TI - Widespread cutaneous inhibition in dorsal column nuclei. PMID- 4318173 TI - Receptive-field organization of the catfish retina: are at least two lateral mechanisms involved? PMID- 4318174 TI - Sensitivity distribution and spatial summation within receptive-field center of retinal on-center ganglion cells and transfer function of the retina. PMID- 4318176 TI - A micro-modification of immune adherence hemagglutination test. PMID- 4318175 TI - Firing of neuron pairs in cat association cortex during sleep and wakefulness. PMID- 4318177 TI - Hyperimmunization of horses with alpha toxoid of Clostridium perfringens. PMID- 4318179 TI - The art of communication. PMID- 4318178 TI - Epidemiological analyses of Japanese encephalitis virus spread from mosquitoes to pigs through 5 years. PMID- 4318180 TI - [The reaction of the nervous elements of the human epiglottis in pulmonary tuberculosis]. PMID- 4318181 TI - Congenital generalized lipodystrophy. PMID- 4318182 TI - The effect of variation of lipolysis after nicotinic acid and acetylsalicylate on blood concentrations of 3-hydroxybutyrate and acetoacetate in starving subjects. PMID- 4318183 TI - [Krukenberg's tumor]. PMID- 4318185 TI - [Experience report on a double blind study with helopanflat in treatment of meteorism]. PMID- 4318184 TI - [Early diagnosis of urologic tumors]. PMID- 4318186 TI - [Fungal diseases of the postoperative middle ear cavity (review of the literature)]. PMID- 4318187 TI - [A mixed tumor of the roopharynx of large dimensions]. PMID- 4318188 TI - [A mixed tumor of the oropharynx of large dimensions]. PMID- 4318189 TI - [Juvenile angiofibroma of the nasophapharynx]. PMID- 4318190 TI - Role of acetylcholine in mammalian neuromuscular transmission. PMID- 4318191 TI - [In vitro study of the mechanism of the curare-like mechanism of action of gallamine-acetylenic]. PMID- 4318192 TI - Electron microscopy for the diagnosis of cutaneous viral infections. PMID- 4318193 TI - [Cytological and histochemical characteristics of the maxillary kidney of chilopods]. PMID- 4318194 TI - [Enhancement, by addition of diethylaminoethyl-dextran, of the infectivity of ribonucleic acid from foot-and-mouth disease virus]. PMID- 4318195 TI - [Progress in the diagnosis and evaluation of functional disorders of the peripheral nerves]. PMID- 4318196 TI - Uridine uptake by rat uterus: Influence of injection route. PMID- 4318197 TI - Biologic and immunologic similarities between rat and human adrenocorticotropin (ACTH). PMID- 4318198 TI - Adrenocortical function in the hamster. Sex differences and effects of gonadal hormones. PMID- 4318199 TI - Carcinogenicity of sterigmatocystin. PMID- 4318200 TI - Pitfalls of functional tests for the establishment of the etiology of Cushing's syndrome in childhood and adolescence. PMID- 4318201 TI - Effect of metyrapone on secretion of growth hormone in man. PMID- 4318202 TI - The action of dibutyryl cyclic 3',5'-adenosine monophosphate on the mouse thyroid gland in vitro. PMID- 4318203 TI - The stimulation of insulin release by essential amino acids from rabbit pancreas in vitro. PMID- 4318204 TI - An adrenocorticotrophin-inhibiting substance in the plasma of hypophysectomized rats. PMID- 4318205 TI - Further evidence on the formation of poliovirus proteins. PMID- 4318207 TI - Electron spin resonance spectra of isolated ferrihemoglobin (alpha, beta and gamma) chains--an attempted correlation with optical absorption spectra. PMID- 4318206 TI - Ultrastructural characterization of F-actin isolated from Acanthamoeba castellanii and identification of cytoplasmic filaments as F-actin by reaction with rabbit heavy meromyosin. PMID- 4318208 TI - Hepatic gluconeogenesis and glycolysis in chickens fed "carbohydrate-free" diets. PMID- 4318209 TI - Rate of rise of Purkinje and transitional cells action potential and the propagation across the Purkinje-myocardium junction. PMID- 4318210 TI - Calcium ions and the propagation of impulses through the mammalian heart junctional regions. PMID- 4318211 TI - [Alteration of the activity of phosphatase and succinate dehydrogenase in the mucous membrane of the small intestine in radiation lesions in early ontogenesis]. PMID- 4318212 TI - Pathogenicity of avian reovirus and its influence on the infection of Mycoplasma gallisepticum in chickens. PMID- 4318213 TI - The value of electron microscopy in nerve biopsy. PMID- 4318214 TI - Adrenal insufficiency in two male infants. PMID- 4318215 TI - Military implications of sleep patterns in transport aircrew. PMID- 4318216 TI - [Treatment of burns in practice]. PMID- 4318217 TI - [Studies on the pharmacodynamics of carbochromen]. PMID- 4318218 TI - ATP-inhibited ribonuclease of Bacillus subtilis. I. Purification and general properties. PMID- 4318219 TI - [Kinetics of the change in the concentration of free radicals during the development of the solid form of sarcoma 37]. PMID- 4318221 TI - [Change in the antioxidative activity of lipids during the development of transplantable hepatoma 22-a]. PMID- 4318220 TI - [Rhythm of nerve cell respiration in tissue culture]. PMID- 4318222 TI - [Increase in unsaturated fatty acids during tumor growth]. PMID- 4318223 TI - [Study of irradiated interferon by biological and EPR methods]. PMID- 4318224 TI - [Kinetics of the change in free radical content during the development of Walker carcinosarcoma and the action of Thio-TEPA]. PMID- 4318225 TI - [EPR study of non-heme iron in fractions of Azotobacter vinelandii]. PMID- 4318226 TI - [Nature of the interaction with oxygen of the paramagnetic centers in irradiated proteins]. PMID- 4318228 TI - [Electron structure of the radicals of gamma-irradiated glycine and tyrosine and their photoinduced reactions]. PMID- 4318227 TI - [Study of dynamic structure of proteins and enzymes by specific luminescent and paramagnetic labels]. PMID- 4318229 TI - [Change in antioxidative activity of mice liver lipids during induction of hepatoma with orthoaminoazotoluol]. PMID- 4318230 TI - [EPR study of free radical products formed by the effect of ultraviolet light on bacteriophage suspensions, and in solutions of phage DNA and phage protein at 77 degrees K]. PMID- 4318232 TI - [EPR spectra of seeds germinating in heavy and ordinary water]. PMID- 4318231 TI - [Determination of relaxation parameters of paramagnetic centers in biological objects by continuous saturation of EPR signals and by transmission effects]. PMID- 4318233 TI - [Nature of paramagnetic centers and mechanism of their phototransformations in gamma-irradiated monocrystal of glycine]. PMID- 4318234 TI - [Paramagnetic nitrosyl complexes of heme and nonheme iron]. PMID- 4318235 TI - [State of water in living tissues (results of NMR-spin echo studies)]. PMID- 4318236 TI - [Formation of photoinduced EPR signal under different conditions of irradiation of photosynthesizing objects]. PMID- 4318237 TI - [Angioma of the papilla]. PMID- 4318238 TI - [Treatment of pain in malignant neoplasms]. PMID- 4318240 TI - [The activity of the cytochrome oxidase-cytochrome C enzyme system and the concentration of copper in the tissues of animals in experimental leukemia]. PMID- 4318241 TI - Sleep laboratory evaluation of psychoactive drugs. PMID- 4318242 TI - [The effectiveness of the complex treatment of chronic colitis patients at Essentuki health resort]. PMID- 4318239 TI - [Changes in animal cerebral tissue respiration, sulfhydryl group and free radical concentration during anemia formation and hyperbaric oxygenation]. PMID- 4318243 TI - On methane oxidizing bacteria in fresh waters. I. Introduction to the problem and investigations on the presence of obligate methane oxidizers. PMID- 4318244 TI - Role of bacteria in modifying virulence of Entamoeba histolytica. Studies of amebae from axenic cultures. PMID- 4318245 TI - Clinical evaluation of metronidazole in hepatic amebiasis. PMID- 4318246 TI - Increased mitotic activity of the parafollicular cells of the dog thyroid in experimentally induced hypercalcemia. PMID- 4318247 TI - Infectious mononucleosis: recent developments. PMID- 4318248 TI - Hetrogeneity of human platelets. 3. Glycogen metabolism in platelets of different sizes. PMID- 4318249 TI - [Beryllium granuloma]. PMID- 4318250 TI - [Extramammary Paget's disease]. PMID- 4318251 TI - [Abrikosov tumor]. PMID- 4318253 TI - Antitumor activity of 3-(substituted cinnamoyl)pyridine and 1-Oxide. PMID- 4318252 TI - Initial toxicity study of sangivamycin (NSC-65346). PMID- 4318254 TI - [Histological and histochemical studies of the placenta of white rats in experimental D-3 hypervitaminosis]. PMID- 4318255 TI - Unusual osseous metastases of hepatoma. PMID- 4318256 TI - [Effect of synthetic human ACTH on adrenal cortex function in man and in the rat]. PMID- 4318258 TI - [Water retention caused by ACTH as a test of adrenal gland function]. PMID- 4318257 TI - [Pathological importance of changes in the nuclear volume of liver cells]. PMID- 4318259 TI - [Sensitization and anaphylactic shock in rabbits against a background of ACTH, hydrocortisone and DOCA administration]. PMID- 4318260 TI - [The effect of the combined action of ACTH and cortisone on the growth of Brown Pearce carcinoma]. PMID- 4318261 TI - Susceptibility to an avian leukosis-sarcoma virus: close association with an erythrocyte isoantigen. AB - A dominant gene for susceptibility to early steps of cellular infection by subgroup B avian leukosis-sarcoma viruses is associated with the presence of an erythrocyte isoantigen. This gene may control both an isoantigen and a cell membrane receptor for an oncogenic virus. PMID- 4318263 TI - A dialyzable toxic factor in uremia. PMID- 4318262 TI - Pregnancies after chemotherapy of trophoblastic neoplasms. AB - We have analyzed 88 pregnancies in 50 women who had previously been treated for gestational trophoblastic neoplasms with chemotherapeutic agents. No increase in fetal wastage, congenital abnormalities or complicated pregnancies was noted, suggesting that these drugs do not damage human oocytes in the doses and time periods used. The possibility that recessive mutations have been induced but were undetected cannot be evaluated definitively at present. PMID- 4318264 TI - Studies of lipochromes in uremic patients and normal controls. II. Isolation and identification of carotenoids and lipochromes and their oxidation products in plasma. PMID- 4318265 TI - Experience with maintenance peritoneal dialysis in the home. PMID- 4318266 TI - Intercellular connections between germ cells in the developing human ovary. PMID- 4318267 TI - Effect of metabolic activators, inhibitors and drugs on the proteolytic activity of Entamoeba histolytica. PMID- 4318269 TI - Latent cytomegalovirus infection and blood transfusion. PMID- 4318268 TI - [The use of diethylaminoethyl-dextran (DEAE-D) as adjuvant for immunization of guinea pigs with inactivated foot-and-mouth disease (FMD) virus]. PMID- 4318270 TI - Effect of furosemide and hydrochlorothiazide on plasma renin activity in man. PMID- 4318271 TI - An attempt at combining corticotrophin with long-term corticosteroid therapy. With a view to preserving hypothalmic-pituitary-adrenal function. PMID- 4318272 TI - On the binding of mammalian cytochrome c in NADH- and succinate-cytochrome c reductase from Rhodospirillum rubrum. PMID- 4318273 TI - Nicotinamide adenine dinucleotide-dependent formate dehydrogenase from Rhodopseudomonas palustris. PMID- 4318274 TI - The metabolism of 2-furoic acid by Pseudomanas F2. AB - 1. Pseudomonas F2 isolated by enrichment culture on 2-furoic acid and grown with it as carbon source oxidized the compound with a Q(o) (2) of 170mul./mg. dry wt./hr. and the overall consumption of 2.5mumoles of oxygen/mumole of substrate. 2. In the presence of 1mm-sodium arsenite, oxygen uptake was restricted to 0.54mumole/mumole of 2-furoate oxidized, with the formation of 0.86mumole of 2 oxoglutarate/mumole of 2-furoate. 3. Cell suspensions, disrupted in a French pressure cell and centrifuged at 27000g, yielded supernatants capable of catalysing the slow oxidation of 2-furoate (0.17mumole/mg. of protein/hr.). 4. Fractionation of 27000g supernatants at 200000g yielded a soluble enzyme fraction capable of catalysing the oxidation of 2-furoate only in the presence of added 200000g pellet or of Methylene Blue. 5. The 2-furoate-stimulated uptake of oxygen or the anaerobic reduction of Methylene Blue by dialysed 27000g supernatant required the addition of ATP and CoA, and the rate of oxygen uptake was further enhanced by the addition of magnesium chloride and NAD(+). 6. The role of ATP and CoA in the formation of 2-furoyl-CoA was demonstrated by the accumulation of 2 furoylhydroxamic acid in the presence of hydroxylamine. 7. Dialysed 200000g supernatant, treated with Dowex 1, required the addition of ATP, CoA and Methylene Blue before it could oxidize 2-furoate to 2-oxoglutarate, which was trapped in unitary stoicheiometric yield as its phenylhydrazone. Magnesium chloride and NAD(+) were not stimulatory in this system. The oxidation of 2 furoate to 2-oxoglutarate was not inhibited by substrate analogues, metal ion chelating agents, thiol-active compounds or inhibitors of cytochrome-mediated electron transport. 8. No evidence was obtained for the intervention of 2,5 dioxovalerate as an intermediate in 2-oxoglutarate formation. PMID- 4318277 TI - Management of patients recently arrived from the tropics. PMID- 4318276 TI - Survival after orthotopic liver transplantation: a follow-up report of two patients. AB - Two adult patients with terminal fatal liver disease were treated by orthotopic transplantation. One survived 11 months and died as a result of recurrent biliary intra-abdominal sepsis; the other patient is alive and well in the 18th month after transplantation and has virtually normal liver function. It is concluded that liver grafting can provide valuable therapy. PMID- 4318275 TI - Intersubstrate competitions and evidence for compartmentation in mitochondria. AB - 1. The respiration of rat liver mitochondria was compared with different substrates, and with sucrose and saline media. The maximum rates of oxidation obtainable from glutamate, oxoglutarate, glutamate+malate, or succinate were higher in the saline (120mm)-tris (20mm) media than in sucrose (250mm)-tris (20mm) mixtures, but the rate with beta-hydroxybutyrate was unchanged. Addition of valinomycin to a medium with sucrose and 5mm-potassium chloride led to rates similar to those measured in saline media; beta-hydroxybutyrate oxidation was unaffected. 2. Some pairs of substrates together provided a rate of oxidation greater than the sum of the separate rates. This is accountable if removal of inhibitory products, such as oxaloacetate, compensates for any mutual competition between the substrates. Other pairs showed rates less than the sum of the separate rates, which is accountable by mutual competition. beta-Hydroxybutyrate and other substrates, except succinate, provided strictly additive rates; with succinate there was evidence for competition. In the presence of rotenone, succinate oxidation was slowed down by citrate, oxoglutarate (+arsenite) and by beta-hydroxybutyrate. 3. The accumulation of substrates in the mitochondria was measured as a function of the concentration and in the presence of possible competitors, or with a potassium salt and valinomycin to induce uptake of K(+). The quantities of oxoglutarate, glutamate and pyruvate increased with the mitochondrial K(+), but the quantities of beta-hydroxybutyrate did not. Most substrates competed between themselves, although citrate accumulation was somewhat increased by oxoglutarate. beta-Hydroxybutyrate competed for accumulation only with succinate, and was unaffected by other substrates. beta Hydroxybutyrate accumulation was almost linearly related to applied concentration (up to 5mm), and its rate of reaction was linearly dependent on concentration up to the highest value tested (0.75mm). Hence it differed from other substrates, which are accumulated and oxidized in a manner that follows a saturation law, with K(m) values about 1-10mm. 4. It is concluded that beta-hydroxybutyrate is stored in a compartment operationally distinct from the space containing K(+) and the NAD-linked substrates. It seems likely that succinate enters both compartments. 5. The degree of accumulation and the effectiveness of an anion as a competitor (as judged by low K(i)) increases with the net charge. This is indicative of an electrostatic interaction with positive sites. It is suggested that the facilitating influence of dicarboxylic acids on the permeation of tricarboxylic acids may be due to the assembling of pairs of the positive carriers by the former, so favouring the chance of there being three or more carriers in a small volume of space near the boundary to interact with the tricarboxylic anion. PMID- 4318278 TI - Plasma 11-hydroxycorticoid levels after carbenoxolone sodium. AB - A definite rise in plasma 11-hydroxycorticoid levels has been shown in eight patients with duodenal ulcer following the oral administration of carbenoxolone sodium. A similar rise was seen in one patient with sarcoidosis whose pituitary A.C.T.H. secretion had been acutely suppressed with dexamethasone. No such rise, however, was seen in three patients suffering from adrenal insufficiency. It is suggested that carbenoxolone acts directly on the adrenal cortex, causing an increased production of corticosteroids. PMID- 4318279 TI - Venous leg ulcers. PMID- 4318280 TI - Cushing's syndrome, a personal view. PMID- 4318281 TI - New growth and viruses. PMID- 4318282 TI - Cortisol and growth hormone secretion in relation to linear growth: patients with Still's disease on different therapeutic regimens. AB - Linear growth was studied in 20 children suffering from Still's disease on various treatment regimens, and their ability to secrete growth hormone and cortisol was investigated. Growth recovered on reducing daily corticosteroid therapy or on changing to an alternative regimen. Retardation of growth was not due to an absolute inability to secrete growth hormone. Basal plasma cortisol levels and the plasma cortisol response to hypoglycaemia were reduced in patients on daily steroid therapy, but patients on alternate-day prednisone did not differ significantly in this respect from those on non-steroid regimens. Those on alternate-day corticotrophin showed preservation of the circadian rhythm but a subnormal response to hypoglycaemia. PMID- 4318284 TI - Streptozotocin treatment of malignant islet cell tumour. PMID- 4318283 TI - Benign intracranial hypertension following corticosteroid withdrawal in childhood. AB - In an 18-month period seven children who were treated for a variety of neurological and non-neurological diseases, and in whom the corticosteroid or corticotrophin dosage was reduced, developed a syndrome indistinguishable from "benign intracranial hypertension." The total duration and rate of reduction of corticosteroid dosage and perhaps an underlying susceptibility to cerebral oedema appear to be important factors in this syndrome. Usually patients can be treated without the need for special neuroradiological studies. Possibly mild forms of this condition are not uncommon, but its pathogenesis is still uncertain. PMID- 4318285 TI - Cirrhosis of the aged and senile cirrhosis--are there two conditions? PMID- 4318286 TI - Antigen as a function of RES blockade. PMID- 4318287 TI - Inhibition of Rous virus-transformed cell focus formation by normal chicken leukocytes. PMID- 4318289 TI - [Progress in the diagnosis and evaluation of the functional disorders of the peripheral nerves]. PMID- 4318288 TI - Angiotensin I in renal and extra-renal tissues. PMID- 4318291 TI - Infantile polymyoclonia-opsoclonus syndrome and neural crest tumors. PMID- 4318290 TI - [Changes of the cranial nerves in the gliomas of the brain stem]. PMID- 4318292 TI - Chromosome analysis of glioblastoma multiforme. PMID- 4318294 TI - [Activity changes of spinal neurones during and after asphyxiation]. PMID- 4318295 TI - [Bone age and dental age in patients with hypophyseal dwarfism. Considerations and reports]. PMID- 4318293 TI - [Trans-splenic lipiodol hepatography. Animal experiments]. PMID- 4318296 TI - [Polyacrylamide gel separation of 2 isoenzymes exhibiting phosphatase activity in the human saliva]. PMID- 4318297 TI - [Cerebral gangliosides and their role in the synaptic transmission of excitation]. PMID- 4318298 TI - [Reticulohistiocytoma]. PMID- 4318299 TI - [Background changes in gallbladder epithelium in cancer]. PMID- 4318300 TI - [An electron microscopic study of cells of tumors induced in hamsters by Rous virus following their prolonged passage in vitro]. PMID- 4318302 TI - [The hygienic significance of trace elements and foreign materials in drinking water]. PMID- 4318301 TI - [The activity of various enzymes in animal poisoning by carcinogenic aminodiphenyl derivatives]. PMID- 4318303 TI - [Comparative studies on the behavior of serum glutamic-oxaloacetic and glutamic pyruvic transaminases in the golden hamster under various experimental conditions of extra-intestinal amebiasis]. PMID- 4318304 TI - [Laboratory studies of the problem of epidemic hepatitis. 3]. PMID- 4318305 TI - [On antigen relationship between herpes simplex virus, herpes virus platyrrhinae (marmoset herpesvirus) and equine abortion virus]. PMID- 4318306 TI - [The yield of clostridia on selective and non-selective media for anaerobic organisms shown on pure cultures of different species of clostridia]. PMID- 4318307 TI - [Virus occurrence in raw sewage sludge and effluent of a biological clarification plant]. PMID- 4318308 TI - [Stable and local electrophysiologic manifestation of the conditioned reflex]. PMID- 4318309 TI - [Results of electrophysiological studies of cortical regulation of the activity of subcortical-stem formations]. PMID- 4318310 TI - [The possibility of ephaptic interaction of neurons through an extracellular electrical field created by them]. PMID- 4318311 TI - Urea inhibition of lactate dehydrogenase. A convenient routine procedure. PMID- 4318312 TI - The state and function of copper in biological systems. PMID- 4318314 TI - [Case suspected to be the sequela of Japanese encephalitis 67 years after the onset]. PMID- 4318313 TI - Cytochrome c peroxidase. PMID- 4318315 TI - [Study of the structure and local conformational transitions of proteins and enzymes by the method of double paramagnetic labels]. PMID- 4318316 TI - [Interaction of hydroxyl ion with quinones in protein solutions]. PMID- 4318318 TI - [Study of synaptic transmission between photoreceptor and horizontal cell by electric stimulations of the retina]. PMID- 4318317 TI - [UV-induced formation of free radicals by photosensitized purines and pyrimidines in alcohols at 77 degrees K]. PMID- 4318319 TI - [EPR study of the structural condition of proteins during modelling of muscle contraction and relaxation]. PMID- 4318320 TI - Efficacy of whooping-cough vaccines used in the United Kingdom before 1968. A preliminary report to the Director of the Public Health Laboratory service by the Public Health Laboratory Service Whooping-Cough Committee and Working Party. AB - In a large survey of the efficacy of pertussis vaccines made in 33 areas in the United Kingdom during the period 1 November 1966 to 31 October 1967 a total of 3,564 households were investigated. Nine hundred and seventy-seven strains of Bordetella pertussis and 6 strains of Bord. parapertussis were isolated from persons in 792 households.After contact in the home 56% of fully vaccinated children under 5 years of age developed a paroxysmal cough, and in more than two thirds of these patients the diagnosis was confirmed bacteriologically. This suggests that pertussis vaccination was not very effective. A comparison with the attack rate in unvaccinated children also indicates a poor protection from vaccination.NONE OF THE FOLLOWING FACTORS APPEARED TO BE RESPONSIBLE FOR THE POOR PROTECTION AFFORDED BY VACCINATION: vaccination in early infancy, a long interval since vaccination, and the absence of booster doses.Almost all the children in the survey had been given vaccines from a single manufacturer, and therefore a comparison of the efficacy of vaccines prepared by different manufacturers was inconclusive. All the vaccinated children in the survey had been vaccinated before or during 1967. The efficacy of current preparations will require to be assessed by continuing surveillance. PMID- 4318321 TI - Surveillance of acute respiratory virus infections in general practice. AB - The ordinary postal system provides a simple method for the transportation of specimens for virus isolation to the laboratory. This was used to carry out an epidemiological survey, in general practice, of respiratory viruses in patients with acute respiratory disease. Three distinct outbreaks of myxovirus infections were recognized and most other types of respiratory viruses were isolated sporadically. After the initial "pilot" phase of the study an isolation rate of 24% was obtained over the months from October 1968 to June 1969 (20% isolations from adults' specimens and 29% from those of children). PMID- 4318323 TI - [Cellular mechanisms of action of hormones]. PMID- 4318322 TI - Advances in asthma. Treatment. PMID- 4318324 TI - [Epilepsy is a disease not a possession]. PMID- 4318325 TI - [Nature of products formed in cells infected by poliovirus under hypotonic conditions]. PMID- 4318326 TI - [Catalase and cytochromoxidase activity in plants of different radiosensitivity]. PMID- 4318327 TI - [Role of enzymes of the hexosomonophosphate shunt in the control of carbohydrate metabolism in early embryogenesis]. PMID- 4318329 TI - [Genetic analysis of the effect of Rous sarcoma virus (Schmidt-Ruppin strain) on mutation in Drosophila]. PMID- 4318328 TI - [EPR spectra of free-radical products of the reaction between ninhydrin and peptides]. PMID- 4318330 TI - [Rate of reduction of certain pentoses by extracts from Candida pulcherrima yeast]. PMID- 4318331 TI - [Central transformation of impulses sent by the head receptors to the neurons of wing muscles in the locust]. PMID- 4318332 TI - Respiratory control capacity and electrophoretic mobility of tumor cell mitochondria. PMID- 4318333 TI - [Reshaped stroma epithelioma of the parotid children]. PMID- 4318335 TI - Nucleoside phosphatase activities and submicroscopic localization of adenosine triphosphatase activity in gustatory epithelium. PMID- 4318334 TI - Separation of intact cortical granules from homogenate of unfertilized sea urchin eggs by zonal centrifugation. PMID- 4318336 TI - [Tumors of the salivary glands]. PMID- 4318337 TI - Proinsulin secretion by a pancreatic beta-cell adenoma. Proinsulin and C-peptide secretion. PMID- 4318338 TI - Insulin and proinsulin. PMID- 4318339 TI - [Studies on the time of survival of Cl. perfringens in a sample of naturally contaminated meat preserved at +4 degrees, and on the heat resistance of its spores]. PMID- 4318340 TI - [Diagnostic verification of cytomegalovirus infection]. PMID- 4318341 TI - [Synthetic ACTH therapy in allergic diseases]. PMID- 4318342 TI - Enteroviruses associated with the hemolytic-uremic syndrome. PMID- 4318343 TI - Long-term follow-up of cytomegalic inclusion disease of infancy. PMID- 4318344 TI - Cytomegalovirus and microcephaly. PMID- 4318345 TI - Enzymatic hydroxylation of benzopyrene and its relationship to cytotoxicity. AB - Aryl hydrocarbon hydroxylase, an inducible microsomal enzyme system, has been measured in cultures of normal and transformed hamster, mouse, and human cells. In order to determine the highest level of enzyme, the cells were induced by pretreatment with benz(a)anthracene. A correlation was found between the level of enzyme activity and the susceptibility of the cells to the cytotoxicity produced after treatment with benzopyrene. The results indicate that aryl hydrocarbon hydroxylase is the enzyme system responsible for cell susceptibility to the cytotoxic effect of benzopyrene and the toxic effect of benzopyrene is due to its enzymatic conversion to a cytotoxic metabolite. 3-Hydroxybenzopyrene, one of the products of the enzymatic hydroxylation of benzopyrene, was found to be cytotoxic to cells that were either susceptible or resistant to the cytotoxic effect of benzopyrene. PMID- 4318346 TI - SV40 gene activity during lytic infection and in a series of SV40 transformed mouse cells. AB - Transcription of SV40 DNA was measured during lytic infection and in five SV40 transformed mouse cell lines. During productive infection, 50 per cent of viral DNA reacted with saturating amounts of lytic RNA. Varying portions of the SV40 genome were transcribed in transformed mouse cells, ranging from 15 per cent in a line which failed to yield virus, to 50 per cent in one line from which high titers of virus were obtained following cell fusion. The RNA from the SV40 transformed cell line, which saturated 50 per cent of the viral DNA, could not be distinguished from SV40 lytic RNA in reciprocal competition-hybridization experiments. These results suggest that some block or defect, subsequent to the transcription of SV40 DNA, prevents the appearance of progeny virus in this transformed 3T3 cell. PMID- 4318347 TI - Phosphorylation of liver histone following the administration of glucagon and insulin. AB - The administration of glucagon to rats causes a marked increase in the phosphorylation of a specific serine residue in lysine-rich (f1) histone of liver during a one-hour period following the administration of the hormone. It is proposed that histone phosphorylation is the mechanism by which glucagon, and perhaps other hormones whose actions are mediated by adenosine 3',5'-cyclic phosphate (cyclic AMP), induce RNA synthesis in target tissues. The incorporation of (32)P-phosphate into lysine-rich histone is determined by isolation of a tryptic peptide which contains the phosphorylated serine residue. This peptide is identical to the major tryptic phosphopeptide obtained from lysine-rich histone after phosphorylation in vitro by a purified cyclic AMP-dependent liver histone kinase preparation; the partial sequence Lys-Ala SerPO(4)(Thr,Ser,Glu,Pro(2),Gly,Val,Ile,Leu)Lys has been determined for the peptide. Hydrocortisone and adrenocorticotrophic hormone do not cause a detectable increase in histone phosphorylation in liver. However, insulin, which like glucagon induces an actinomycin sensitive synthesis of liver enzymes, also causes increased histone phosphorylation. PMID- 4318348 TI - Complementary nuclear RNA's of murine sarcoma-leukemia virus complex in transformed cells. AB - The high molecular weight RNA (S(20,w) = 69S) of murine sarcomaleukemia virus (MSV-MLV) complex dissociated into 37S subunits when heated to 95 degrees C for 2 minutes. Specific annealing tests revealed that the viral RNA had complementarity with two heterogeneous RNA species from the nuclei of cells (78 A1) transformed by and chronically infected with this virus complex. The two nuclear RNA species that hybridized with the viral RNA had sedimentation constants ranging from 31 36S and 18-22S, respectively. There was no specific annealing between viral RNA and the cytoplasmic RNA of the 78 A1 cells. The detection of the complementary RNA strands of MSV-MLV suggests that this oncogenic virus complex may replicate in a fashion similar to that of the non-oncogenic RNA viruses, but may differ in that the complementary strands are found in the nucleus rather than in the cytoplasm of the transformed cells. PMID- 4318349 TI - [Extracts of the gallbladder endothelium. Biological and pharmacodynamic action]. PMID- 4318350 TI - [Para-phalloid syndrome with severe icterus due to "Lepiota Helveola" (Sensu Lato)]. PMID- 4318351 TI - [Hazards of administering vitamin B12 to cancer patients]. PMID- 4318352 TI - [Current aspects of chronic lymphatic leukemia]. PMID- 4318353 TI - [Pregnancy and adrenal insufficiency]. PMID- 4318354 TI - Diphenylhydantoin (Dilantin) hypersensitivity. PMID- 4318355 TI - Peripheral neuropathy caused by catfish pectoral spine. PMID- 4318356 TI - Primary linitis plastica carcinoma of the colon. PMID- 4318357 TI - [After-care device for automatic active movement of the hip joint]. PMID- 4318358 TI - [On an epidemic outbreak of poliomyelitis, type 3, in the Voivode County of Poznan in 1968]. PMID- 4318359 TI - [Experimental double infection of sheep with vaccinia virus and sheep-pox or orf virus. A contribution on the problem of contamination of smallpox dermovaccines with foreign viruses]. PMID- 4318360 TI - [Phosphoryl-choline reaction: cytidyltransferases in secondary myelinic degeneration]. PMID- 4318361 TI - [Aspartate aminotransferase in peripheral nerves in Wallerian degeneration]. PMID- 4318363 TI - [Morphology of intramuscular axonal endings in 2 cases of Walton's benign congenital hypotonia]. PMID- 4318362 TI - [Various regressive mechanisms of the muscle fiber in neurogenic atrophy and myodystrophy]. PMID- 4318364 TI - Effect of nicotinic acid on ACTH and noradrenaline stimulated lipolysis in the rabbit. I. In vivo studies. PMID- 4318365 TI - Inhibition by prostaglandin E-1 of the sympathetic neuromuscular transmission in the rabbit heart. PMID- 4318366 TI - Sodium-angiotensin synergism in central regulation of water and salt metabolism. PMID- 4318367 TI - On brain power. PMID- 4318368 TI - [Ultrastructural study of a bronchial granular cell tumor]. PMID- 4318369 TI - [Bilateral nephroblastomatosis (renal hyperplasia due to polynephronic dysplasia)]. PMID- 4318370 TI - Research report 1967-1969 of the Institute of Experimental Biology and Genetics. PMID- 4318371 TI - Comparison of the ultrastructural demonstration of cytochrome oxidase activity with three bis(phenylenediamines). PMID- 4318372 TI - [A new case of arteriographied sub-ungual glomic tumor]. PMID- 4318374 TI - Model for DNA replication by Kornberg's DNA polymerase. PMID- 4318373 TI - Rheumatic heart disease from the standpoint of streptococcal antibodies. PMID- 4318375 TI - Low magnesium and phospholipid content of cell wals of Pseudomonas aeruginosa resistant to polymyxin. PMID- 4318376 TI - Radioimmunoassay of angiotensin II in plasma. PMID- 4318377 TI - An unusual type of hypokalaemic alkalosis with a disturbance of renin and aldosterone. PMID- 4318378 TI - The effect of alterations in adrenocortical function on the mouse uterine weight response to human chorionic gonadotrophin. PMID- 4318379 TI - Spontaneously hypertensive rats. PMID- 4318380 TI - An autopsy case of collision tumor. PMID- 4318381 TI - [Tumors of the septum pellucidum--with special reference to angiography findings]. PMID- 4318382 TI - [Case of appalic syndrome from cardiac arrest---4-year observation of clinical symptoms and electroencephalography]. PMID- 4318383 TI - [Studies of glucose concentration in plasma after experimental changes in blood pressure homeostasis in rabbits. II. Effect of synthetic angiotensin II on the blood glucose concentration of neurogenic interoreceptive hypertonic experimental animals]. PMID- 4318384 TI - [Evaluation of SiO2 determination from lung tissue and adjoining lymph nodes by the method of King, Stacy, Holt, Yates and Pickles]. PMID- 4318385 TI - Effect of adrenocorticotropic hormone and corticosteroid on release of catecholamine from adrenal medulla. PMID- 4318386 TI - [The nature of the paradoxical phase of sleep]. PMID- 4318387 TI - [Clinical application of a new synthetic ACTH, DW-75 (D-serine-1-norleucine-4 valinamide-25-beta-1-25-corticotropin)]. PMID- 4318389 TI - Effect of surgical intervention on immunological resistance against tumor. PMID- 4318390 TI - High glutathionase activity in "minimum deviation" Reuber hepatoma H-139. PMID- 4318391 TI - Direct isolation of C-type particle-harboring cells from mouse embryo in soft agar medium. PMID- 4318392 TI - Heritable congenital tibiofemoral subluxation. Clinical features and surgical treatment. PMID- 4318393 TI - [2 cases of functioning insulinoma]. PMID- 4318395 TI - [Therapeutic experience of insulinoma]. PMID- 4318394 TI - [Insulinoma, with special reference to dynamics of serum insulin]. PMID- 4318396 TI - [Clinical and histological aspects of insulinoma]. PMID- 4318398 TI - [ACTH-secreting tumor]. PMID- 4318397 TI - [Glucagonoma]. PMID- 4318399 TI - [Autopsy case of islet cell tumor with Cushing's syndrome]. PMID- 4318400 TI - [Treatment of neurologic diseases with synthetic corticotropin (beta-1-24 corticotropin)]. PMID- 4318401 TI - [Interpretation of some myasthenic symptoms]. PMID- 4318402 TI - [Chemical and microbiological detection of liberation of antitubercular agents from emulsions and suspension systems. 2. Capreomycin sulfate, viomycin sulfate and kanamycin sulfate]. PMID- 4318403 TI - [Hormonal modeling of connective tissue. I. Modeling by protein and glycoprotein hormones]. PMID- 4318404 TI - [Current status of the laboratory diagnosis of smallpox]. PMID- 4318405 TI - [Diseases of the external female genitalia Abrikosov tumor]. PMID- 4318406 TI - [Virus isolation experiments from aphous oral mucosa diseases]. PMID- 4318407 TI - Infection of herons and domestic fowls with Japanese encephalitis virus with specific reference to maternal antibody of hen (epidemiological study on Japanese encephalitis 26). PMID- 4318408 TI - Alterations in the sleep patterns of infants and young children following acute head injuries. PMID- 4318409 TI - Sleep studies in infancy. Facts, concepts and significance. PMID- 4318410 TI - Mechanism of inhibition of gluconeogenesis by 4-pentenoic acid. PMID- 4318412 TI - Canine Herpesvirus as a suspected cause of neonatal mortality in puppies. PMID- 4318411 TI - Role of adenosine 3',5'-monophosphate in the control of gluconeogenesis. PMID- 4318413 TI - Isolation of a cytopathogenic agent from acute Marek's disease. PMID- 4318414 TI - Suspected encephalomyocarditis virus infection in pigs. PMID- 4318415 TI - [Pathology of the cytomegalic disease]. PMID- 4318416 TI - Renal-clip hypertension in rabbits immunized against angiotensin II. PMID- 4318417 TI - Circulatory and humoral changes in the reversal of renovascular hypertension in sheep by unclipping the renal artery. PMID- 4318418 TI - Luteinizing hormone bioassay based on uptake of radioactive phosphorus by the chick tests. PMID- 4318419 TI - The mammary tumor virus (MTV). PMID- 4318420 TI - 5'-P-forming exonuclease from Actinomyces sp. of coelicolor group, strain No. 5 (exonuclease A 5). Purification and some properties. PMID- 4318421 TI - Chemical structure of tubular and glomerular basement membranes of human kidney. Isolation and characterization of the carbohydrate units. PMID- 4318422 TI - Alkylation studies on a reactive histidine in pig heart malate dehydrogenase. PMID- 4318423 TI - Erythema nodosum leprosum. PMID- 4318424 TI - Erythema nodosum leprosum. PMID- 4318425 TI - Clinical investigation of a radiopaque composite restorative material. PMID- 4318426 TI - The inhibition mechanism of the cytochrome oxidase reaction. I. Inhibition by hydroxylamine. PMID- 4318428 TI - Epidemiology of respiratory infection in adults. PMID- 4318427 TI - Acute respiratory diseases: investigative methods. PMID- 4318429 TI - Epidemiology and natural history of respiratory infections in children. PMID- 4318430 TI - Some respiratory virus and mycoplasma infections of animals. PMID- 4318431 TI - Respiratory viruses. PMID- 4318432 TI - Genetic resistance of fowl to MH2 reticuloendothelioma virus. PMID- 4318434 TI - The refractory state after induction of interferon with double-stranded RNA. PMID- 4318433 TI - Encephalomyocarditis virus multiplication in the presence of pyronine. PMID- 4318435 TI - The proteins of biologically active sub-units of vesicular stomatitis virus. PMID- 4318436 TI - ["Biologic therapy" for 7,400 Sw. Cr. per month]. PMID- 4318437 TI - Possibilities for histochemical demonstration of certain enzymes in the central nervous system with special reference to the spinal cord. II. Phosphatases. PMID- 4318438 TI - [Langerhansian adenoma with psychiatric symptomatology. Demonstration by electron microscopy of insulinogenic grains]. PMID- 4318439 TI - [Ovarian arrhenoblastoma. Consecutive pregnancies]. PMID- 4318440 TI - Clinical evaluation of intolerance to cycloserine. PMID- 4318441 TI - [Changes in hepatic phosphorylases and glucose-6-phosphatase under the influence of the growth hormone in the rat liver isolated and perfused in vitro]. PMID- 4318442 TI - [Ultrastructural and topochemical pathology of testicular feminization. II. Topochemical changes]. PMID- 4318443 TI - [Cytomegaloviruses]. PMID- 4318444 TI - On the molecular species of rat liver phosphatidylinositol. PMID- 4318445 TI - [Pituitary hormones and adrenal cortex hormones in the therapy of internal diseases]. PMID- 4318446 TI - Pancreatic carcinoma. Weekly Clinical Conference of the Section of Gastroenterology of the University of Michigan. PMID- 4318447 TI - Hazard from antibiotics in myasthenia gravis. PMID- 4318448 TI - Mechanisms of polypeptide hormone synthesis. PMID- 4318450 TI - Enzymatic removal of diacetyl from beer. 3. Enzyme protection and regeneration of cofactor. AB - Use of diacetyl reductase, a reduced nicotinamide adenine dinucleotide (NADH) requiring enzyme, to eliminate diacetyl off-flavor in beer was studied. The crude enzyme was extracted from Aerobacter aerogenes and partially purified by ammonium sulfate precipitation or Sephadex chromatography. In the semipure state, the enzyme was inactivated by lyophilization; in a crude state, the lyophilized extract remained stable for at least 4 months at - 20 C. A 50% reduction in specific activity within 5 min was observed when crude diacetyl reductase was suspended (5 mg of protein/ml) in phosphate buffer at pH 5.5 or below; a similar inactivation rate was observed when the crude enzyme was dissolved in a 5% aqueous ethyl alcohol solution. Effective crude enzyme activity in beer at a natural pH of 4.1 required protection of the enzyme in 10% gelatin. Incorporation of yeast cells with the gel-protected enzyme provided regeneration of NADH. Combinations of yeast, enzyme, and gelatin were tested to obtain data analyzed by regression analysis to determine the optimal concentration of each component of the system required to reduce the level of diacetyl in spiked (0.5 ppm) beer to less than 0.12 ppm within 48 hr at 5 C. The protected enzyme system was also effective in removing diacetyl from orange juice (pH 3.8) and some distilled liquors. PMID- 4318449 TI - A genetical and biochemical study of chlorate-resistant mutants of Salmonella typhimurium. PMID- 4318451 TI - Quantitative studies on fabrics as disseminators of viruses. IV. Virus transmission by dry contact of fabrics. AB - Cotton and woolen fabrics and fabrics of synthetic fibers were exposed by direct contact (pipette) and by aerosolization to poliovirus and to vaccinia virus in separate experiments, allowed to dry for 16 hr at 25 C in 35% relative humidity, and randomly tumbled with sterile swatches of the same fabrics for 30 min. By use of a HEp-2 cell assay system, up to 10(3.5) CCID(50) of poliovirus per ml and 10(4.4) CCID(50) of vaccinia virus per ml were recovered from the originally sterile fabrics as early as 1 to 10 min after contact. Maximum transfer of both viruses was achieved with wool blanket material, although high titers of vaccinia virus were recovered from all fabrics tested. Poliovirus placed on the fabrics in an aerosol tended to be transferred to the sterile fabrics at a greater rate than when it was placed on the fabrics by direct contact. The method of exposure had essentially no effect on the rate of transfer of vaccinia virus. PMID- 4318452 TI - Influence of water activity on the growth of Clostridium perfringens. AB - Each of four strains of Clostridium perfringens was grown in modified fluid thioglycolate medium which was adjusted to yield selected water activity (a(w)) levels. The adjustments to secure the desired a(w) levels were made with NaCl, KCl, or glucose. At each a(w) level, further modification was effected to produce four pH values. Cultures were incubated at either 37 or 46 C. The solute used to achieve the reduced a(w) levels appeared to have a definite effect on the magnitude of growth achieved, the rate of growth, and the limiting a(w) at which growth would occur. Use of glucose as the controlling solute permitted growth at the lowest a(w) level tested, 0.960, and yielded the greatest magnitude of growth as measured by turbidity values, at all of the a(w) levels investigated. Cultures grown in the medium with added KCl generally demonstrated the longest lag times and the least amount of growth. Regardless of specific solute used, as the a(w) level was lowered and the pH value decreased within each a(w) level, the rate and amount of growth were lessened. It appeared, however, that low pH values had less effect on inhibiting growth at low a(w) levels than at higher a(w) levels. Those cultures incubated at 46 C generally exhibited shorter lag periods than those at 37 C, although the maximal growth attained was somewhat less than that achieved at 37 C. The response to all of the investigated conditions was similar for each of the four strains tested. PMID- 4318454 TI - Erosive adenomatosis of the nipple. PMID- 4318453 TI - Papular mucinosis in chronic psoriatic erythroderma. Report of a case. PMID- 4318455 TI - [Meningeal gliomatosis. Case report]. PMID- 4318456 TI - Extraction of polyphosphoinositides with neutral and acidified solvents. A comparison of guinea-pig brain and liver, and measurements of rat liver inositol compounds which are resistant to extraction. PMID- 4318458 TI - [An electrophysiologic analysis of the state of the autonomic nerves in experimental thyrotoxicosis]. PMID- 4318457 TI - [A cytochemical study of phagocytosis of quartz dust under the influence of hydrocortisone]. PMID- 4318459 TI - [The encephalitogenic activity of pertussis microbes in different animals]. PMID- 4318460 TI - [Histochemical and histoenzymological data on the chick embryo tibia during its morphogenesis. I. Metabolism of polysaccharides]. PMID- 4318461 TI - [Histochemical and histoenzymological data on the chick embryo tibia during its morphogenesis. II. Intermediate metabolism]. PMID- 4318462 TI - Metabolic adaptations during hepatocarcinogenesis: dietary induction of some enzymes of carbohydrate metabolism during 3'-methyl- and 2-methyl-N,N-dimethyl-4 aminoazobenzene feeding. PMID- 4318463 TI - Effects of hydroxyurea and 6-mercaptopurine on growth and some aspects of carbohydrate metabolism in regenerating and neoplastic liver. PMID- 4318464 TI - Use of a murine sarcoma virus in an in vivo assay for antiviral and antitumor agents. PMID- 4318465 TI - The isolation of normal rat liver h proteins and the immunological reactions of mouse anti-rat liver h protein. PMID- 4318466 TI - Metabolism of renal tumors in situ and during ischemia. PMID- 4318468 TI - Spectrophotometric analyses of cytochromes in ascites hepatomas of rats and mice. PMID- 4318467 TI - Biochemical studies on hormone-responsive mammary tumors in BR6 mice. PMID- 4318469 TI - Mouse strain and breeding stimulation as factors influencing the effect of thymectomy on mammary tumorigenesis. PMID- 4318470 TI - Antigenic analysis of L strain cells: a new murine leukemia-associated antigen, "L". PMID- 4318471 TI - [Nature of the formation of free radicals and chromosome mutations in seeds induced by gamma-rays in relation to the physiological condition of the seed]. PMID- 4318472 TI - [Post-tetanic changes in the orthodromic radicular response in non-narcotized rats after x-irradiation of the spinal cord and compensation]. PMID- 4318473 TI - [Synaptic influences as reasons for quantitative variations in neuronal RNA]. PMID- 4318474 TI - Isolation and characterization of cyanogen bromide-cleaved peptides from a collagenase digest of alpha 1-chain of calf skin collagen. PMID- 4318475 TI - A kinetic study of saccharopine dehydrogenase reaction. PMID- 4318476 TI - The oxidation of malate by mitochondria isolated from cauliflower buds. PMID- 4318477 TI - Studies on the mechanism of squalene biosynthesis. The structure of presqualene pyrophosphate. PMID- 4318478 TI - Three new iron-ligand complexes of human methemoglobin A. PMID- 4318479 TI - Biosynthesis of gossypol. Incorporation of mevalonate-2-14C and isoprenyl pyrophosphates. PMID- 4318480 TI - The synthesis and breakdown of nucleic acids in mammalian cells transformed by oncogenic viruses. I. Purification and properties of an endonuclease from baby hamster kidney cells transformed by polyoma virus. PMID- 4318481 TI - Inhibition by catecholamines of the induction of rat liver glucokinase. PMID- 4318482 TI - Activation of adipose tissue lipase by skeletal muscle cyclic adenosine 3',5'- monophosphate-stimulated protein kinase. PMID- 4318483 TI - Immunochemical studies of foot-and-mouth disease. 8. Detection and quantitation of antibodies by radial immunodiffusion. PMID- 4318484 TI - Changes in IgA and IgG concentrations in nasal secretions prior to the appearance of antibody during viral respiratory infection in man. PMID- 4318486 TI - An overwintering population of Culicoides in Colorado. PMID- 4318485 TI - Relationship of Epstein-Barr virus-induced membrane antigens in lymphoid cells to viral envelope antigens. PMID- 4318487 TI - Tetrahydropapaveroline: an alkaloid metabolite of dopamine in vitro. PMID- 4318488 TI - Augmentation of alkaloid formation from dopamine by alcohol and acetaldehyde in vitro. PMID- 4318489 TI - Selective blockade of potassium-induced contractions of aortic strips by beta diethylaminoethyl-diphenylpropylacetate (SKF 525A). PMID- 4318491 TI - [Angiotensin-aldosterone interrelations in hepatic cirrhosis]. PMID- 4318492 TI - Homotypic and heterotypic interference by defective particles of vesicular stomatitis virus. PMID- 4318490 TI - Facilitatory drug action on the isolated phrenic nerve-diaphragm preparation of the rat. PMID- 4318493 TI - Interferon production by T4 coliphage. PMID- 4318495 TI - Synergistic action of sodium and angiotensin on brain mechanisms controlling water and salt balance. PMID- 4318494 TI - The renin--angiotensin system: inhibition of converting enzyme in isolated tissues. PMID- 4318496 TI - Herpetic paronychia--an occupational hazard of medical personnel. PMID- 4318498 TI - [Pituitary-adrenocortical function in congenital hemolytic anemia]. PMID- 4318497 TI - [Specific proteins in human cancer]. PMID- 4318499 TI - [Section of Jacobson's nerve and of the chorda tympani in parotid fistula and Frey's syndrome]. PMID- 4318500 TI - [Progress in histoenzymologic technics since 1939]. PMID- 4318501 TI - [Organization and function of sensory pathways]. PMID- 4318502 TI - [Vertebral arteriography: main pathologic aspects]. PMID- 4318503 TI - [Cancer of the colon]. PMID- 4318505 TI - Sonar information about breast tumors. PMID- 4318504 TI - Angiography and scanning in liver disease. PMID- 4318506 TI - Postirradiation sarcoma. Including 5 cases after X-ray therapy of breast carcinoma. PMID- 4318507 TI - [Processing ov visual information in the retina of vertebrates]. PMID- 4318508 TI - [Electrochemical mechanisms of generation and transmission of nerve impulses]. PMID- 4318509 TI - [The inactivation of foot-and-mouth disease virus by ethylethyleneimine and the use of the inactivated virus in the preparation of vaccines]. PMID- 4318511 TI - Poliomyelitis surveillance in Kabul City. II. PMID- 4318510 TI - Basis for poliomyelitis surveillance in Kabul City. PMID- 4318512 TI - [On the thermostability of the complement-fixing antigen of canine hepatitis virus]. PMID- 4318513 TI - [Comparative investigations on the suitability of Ellner- and Ducan-Strong medium for sporulation of the 6 types of Clostridium welchii (Cl. perfringens)]. PMID- 4318514 TI - [The induction of nonspecific resistance by lysozyme and aristolochia acid in bacterial and viral infections]. PMID- 4318515 TI - [Serological studies on the incidence of complement-fixing antibodies against cytomegalovirus in Westberlin]. PMID- 4318516 TI - [Osteoarticular tumors of the hand]. PMID- 4318517 TI - Ultrastructural study of a nerve and muscle biopsy from a case of "subacute myelo optico-neuropathy". PMID- 4318518 TI - Spontaneous-occurring tumors in the duck: review of the literature and report of three cases. PMID- 4318519 TI - Avian erythroblastosis: plasma clearance studies. PMID- 4318520 TI - Testing vaccines by the complement fixation test for avian leukosis virus using a short cell culture passage interval. PMID- 4318523 TI - [Nerve action potential in man]. PMID- 4318521 TI - Terminal synthesis of xanthommatin in Drosophila melanogaster. II. Enzymatic formation of the phenoxazinone nucleus. PMID- 4318522 TI - [The collagenolytic activity of human gingiva]. PMID- 4318525 TI - From mice to men. PMID- 4318524 TI - The effect of substituted phenols on liver weights and liver enzymes in the rat: structure-activity relationships. PMID- 4318526 TI - Effect of cholestyramine on the absorption of vitamin D3 and calcium. AB - The absorption of 10 mug doses of vitamin D(3)-(3)H in rats was found to be decreased by the addition of cholestyramine to the diet in an amount sufficient to cause steatorrhoea. Studies in vitro suggested that the effect of cholestyramine was due to its known ability to bind bile salts and thus disrupt micelles containing vitamin D. The absorption of 1 mg (47)calcium chloride was similar in both control and cholestyramine-fed rats, whether estimated by the whole body counting or the faecal excretion technique. These findings show that the administration of cholestyramine causes a reduction in the absorption of vitamin D(3)-(3)H but not of radiocalcium. PMID- 4318527 TI - Reversibility of radiological appearances during clinical improvement in colonic Crohn's disease. AB - Reversion of radiographic signs has been observed in 11 patients with colonic Crohn's disease during treatment. The commonest radiographic change has been healing of ulcers which are often of a collar-stud type or appear as fissures. Radiographic improvement has been associated with clinical improvement. PMID- 4318528 TI - Hypophyseal growth hormone. II. Interaction with other hormones. PMID- 4318529 TI - Macrophage behaviour during the complaisant phase of murine pertussis. PMID- 4318531 TI - Transfer of radiation energy between macromolecules at 77 degrees K. PMID- 4318530 TI - The sequence of enhanced cellular activity and protective humoral factors in murine pertussis immunity. PMID- 4318532 TI - The uninvolved: a study of services for former mental patients. PMID- 4318533 TI - Further psychometric evaluation of older women--the effect of estrogen administration. PMID- 4318534 TI - Adrenocortical responsiveness to stress and ACTH in aging rats. PMID- 4318535 TI - Pitfalls in the preparation of monotypic agglutinating antisera for Bordetella pertussis. PMID- 4318536 TI - Biological activity of 25-hydroxyergocalciferol in rats. PMID- 4318537 TI - A survey of indigenous murine viruses in a variety of production and research animal facilities. PMID- 4318538 TI - On the site of action of hemicholinium-3 at the rat phrenic nerve-diaphragm preparation with special reference to its multiple presynaptic actions. PMID- 4318539 TI - The place of corticosteroids and corticotrophin in the treatment of rheumatoid arthritis. PMID- 4318540 TI - Strain C3H-A-vy-fB mice: ninety percent incidence of mammary tumors transmitted by either parent. AB - Mammary tumorigenesis in C3H-A(vy)fB female mice is not due to milk-borne mammary tumor virus but to factors transmitted at conception. Prominent among these is the A(vy) gene which may increase the virulence or transmissibility of a variant of mammary tumor virus vertically transmitted by either parent, or may increase the tumorigenic response of the mammary tissue. These factors together with the influence of hormones of pregnancy resulted in the high incidence observed. PMID- 4318541 TI - Adenosine 3'-5'-monophosphate in rat pineal gland: increase induced by light. AB - Rats were maintained in alternating periods of 12 hours of light and 12 hours of darkness. The concentration of adenosine 3',5'-monophosphate in pineal gland was six times higher at the end of the light period than at the end of the period of darkness. This effect of light was abolished in blinded animals. PMID- 4318542 TI - Reinnervated eye muscles do not respond to impulses in foreign nerves. AB - Normal movements return to carp eyes after section and regeneration of the IIIrd and IVth nerve trunks. Two months after reinnervation, records of impulses in the inferior oblique nerve during tilting of the body show activity of the normal motoneurons to that muscle, together with discharge patterns characteristic of the antagonistic superior oblique and some of the rectus muscles. These axons must have found their way into the inferior oblique trunk during sprouting at the lesion and must be maintained after reinnervation. Impulses from foreign axons are without detectable effect on eye movement and therefore must be blocked at their termination in the muscle. Previous study of cross-innervated and doubly innervated fish eye muscles revealed only structurally normal neuromuscular junctions. Transmission from foreign junctions in multiply innervated muscle is blocked by competitive molecular recognition and control mechanisms that do not cause degeneration. PMID- 4318544 TI - [Neural transmission in chronic tonsillitis in children and changes under the effect of fangotherapy]. PMID- 4318543 TI - Effects of isomers of acetotoluidide and aminobenzoic acid on the toxicity and carcinogenicity of N-2-fluorenylacetamide. PMID- 4318545 TI - [Pulsed ultrasonic waves in the therapy of pain syndrome in diseases of the peripheral nervous system]. PMID- 4318546 TI - Effect of cortisol on lymphatic lung clearance and on experimental silicosis. PMID- 4318547 TI - Effect of temperature on the transport of nucleosides into Novikoff rat hepatoma cells growing in suspension culture. PMID- 4318548 TI - Contraction response to muscle percussion. Physiology and clinical significance. PMID- 4318549 TI - Cutaneous manifestations in neoplasia. PMID- 4318550 TI - Biosynthesis of angular furanocoumarins. PMID- 4318551 TI - Brain tumor chemotherapy with mithramycin and vincristine. PMID- 4318552 TI - Nongonadal neoplasia in Turner's syndrome. PMID- 4318553 TI - An automated fluorometric method for determination of malate dehydrogenase activity in serum. PMID- 4318555 TI - Multiple cranial nerve signs from supratentorial tumors. PMID- 4318556 TI - Studies on the mode of development of Japanese encephalitis virus in some groups of mosquitoes by the fluorescent antibody technique. PMID- 4318554 TI - Combined therapy in post-operative gas gangrene. PMID- 4318557 TI - Gangliosides in human brain tumors. PMID- 4318558 TI - R.N. refresher courses become a part of the junior college community service program. PMID- 4318559 TI - Leadership aspects of the students' strike. PMID- 4318560 TI - Keeping up with the times. PMID- 4318562 TI - [Neurologic manifestations of acute and chronic kidney failure. Findings of pathogenetic value of metabolism, water-electrolyte balance as well as on the pathology of the blood-brain barrier function]. PMID- 4318563 TI - [Ultrastructure and topochemistry of giant mitochondria and their inclusions in myopathies]. PMID- 4318564 TI - Left ventricular pressure and maximum rate of pressure rise as determinants of myocardial oxygen consumption during hemorrhagic hypotension in dogs. PMID- 4318565 TI - [Thin layer chromatography of gramicidin J in mixture with polymyxin B and E]. PMID- 4318566 TI - The place of neck dissection in the management of parotid tumors. PMID- 4318567 TI - Subcutaneous glomus tumor. PMID- 4318568 TI - Carcinoma associated with tuberculous anorectal fistula. PMID- 4318569 TI - Hepatoma: long-term survival with disseminated tumor treated with 5-fluorouracil. PMID- 4318571 TI - Unusual fermentative, gram-negative bacilli isolated from clinical specimens. II. Characterization of Aeromonas species. AB - Morphological and physiological characterization of 12 Aeromonas strains isolated from clinical specimens demonstrated several important diagnostic features. These included polar arrangement of the flagella; production of oxidase, deoxyribonuclease, amylase, gelatinase, and lipase; lack of ornithine decarboxylase; and sensitivity to polymyxin. Awareness of these features should result in more frequent differentiation of aeromonads from the physiologically similar members of the genus Plesiomonas and the late- or non-lactose-fermenting species of Enterobacteriaceae. PMID- 4318570 TI - Action of bacterial growth on the sarcoplasmic and urea-soluble proteins from muscle. I. Effects of Clostridium perfringens, Salmonella enteritidis, Achromobacter liquefaciens, Streptococcus faecalis, and Kurthia zopfi. AB - Comparisons of the starch-gel patterns of uninoculated aseptic control samples from rabbit and pig muscle with similar samples inoculated and incubated with Clostridium perfringens, Salmonella enteritidis, Achromobacter liquefaciens, and Kurthia zopfii were made. Results indicated that C. perfringens caused extensive alteration in the proteins or enzymes, or both, of the sarcoplasmic fraction of porcine muscle, whereas S. enteritidis and S. faecalis caused complete breakdown of only myoglobin. Neither A. liquefaciens nor K. zopfii showed any measurable amount of proteolysis in the sarcoplasmic fraction from pig muscle. Although some of the bands in the starch-gel pattern of rabbit muscle decreased in size and intensity of staining, complete proteolysis of any protein fraction was absent for all test organisms. The disc-gel patterns of the 8 m urea-soluble proteins showed that C. perfringens caused extensive proteolysis in pig muscle and a lesser extent of proteolysis in rabbit muscle. None of the other organisms utilized in this study had any measurable effect upon the urea-soluble proteins. In addition, a simple procedure for aseptic isolation of muscle samples for studying meat spoilage is outlined. Results indicate that careful sanitation and cleanliness will give suitable samples for meat spoilage investigations. PMID- 4318572 TI - Microbial transformation of 19-hydroxypregnanes. AB - Nocardia species aromatized 19-hydroxyprogesterone, 3beta, 19-dihydroxy-pregn-5 en-20-one 3-acetate and pregn-5-ene-3beta, 19, 20beta-triol 3-acetate, without cleavage of the side chain, into 3-hydroxy-19-norpregna-1,3,5 (10)-trien-20-one. Septomyxa affinis aromatized the ring A and cleaved the side chain of 19 hydroxyprogesterone to yield estrone. With 19-hydroxypregna-4, 7-diene-3, 20 dione as substrate, the transformation was more complex and many products were formed. PMID- 4318573 TI - Detection of foot-and-mouth disease virus antibodies. I. "Passive" hemagglutination test. AB - A passive hemagglutination test has been developed to detect and measure foot-and mouth disease virus (FMDV) antibody by using glutaraldehyde as a coupling reagent. An optimal concentration of 10 to 40 mug of virus per ml with 0.25% glutaraldehyde at 25 C for 1 hr was established for the sensitization of sheep erythrocytes. A reaction time of 18 hr at 4 C or 2 hr at 37 C induced good agglutination in the presence of specific antibody. Sensitization was carried out in phosphate buffer, whereas agglutination and preadsorption of nonspecific agglutinins from sera were performed in gelatin (0.1%, w/v)-stabilized, phosphate buffered saline. An optimal pH of 7.2 was also established for all reactions. Antibodies derived from guinea pigs hyperimmunized by infecting with FMDV, types A, O, and C were both virus-and type-specific. Preliminary experiments showed that strain A-119 and strain A-24 Cruzeiro could also be distinguished by hemagglutination. Parallel hemagglutination and complement-fixation tests showed the former to be two to four times more sensitive than the latter. PMID- 4318574 TI - Survival of virus in chilled, frozen, and processed oysters. AB - Samples of whole and shucked Pacific and Olympia oysters, contaminated with 10(4) plaque-forming units (PFU) of poliovirus Lsc-2ab per ml, were held refrigerated at two temperatures, 5 and - 17.5 C. To study the survival of virus in the oysters under these conditions, samples were assayed for virus content at weekly intervals for as long as 12 weeks. Results indicated that poliovirus would survive in refrigerated oysters for a period varying from 30 to 90 days, depending upon temperature. The survival rate varied from 10 to 13%. To study the extent of the hazard presented by oysters contaminated with virus, samples of whole and shucked Pacific oysters contaminated with 10(4) PFU of poliovirus Lsc 2ab per ml were heat processed in four ways: by stewing, frying, baking, and steaming. Results indicated that virus in oysters withstood these methods of processing. The survival rate varied from 7 to 10% and appeared dependent upon the processing method used. Heat penetration studies showed that the internal temperature in the oyster was not sufficient to inactivate all of the virus present. These results suggest that not only fresh but also refrigerated and cooked oysters can serve as vectors for the dissemination of virus disease if the shellfish are harvested from a polluted area. PMID- 4318575 TI - Characterization of clostridia by gas chromatography differentiation of species by trimethylsilyl derivatives of whole-cell hydrolysates. AB - Trimethylsilyl (TMS) derivatives prepared from whole-cell hydrolysates of 36 strains, representing 10 species of Clostridium were examined by gas-liquid chromatography (GLC). The TMS profile of each species contained a group of peaks which characterized the species. Variation among strains within a species was much lower than variation between species. Some of the closely related clostridia could be differentiated by comparing their TMS profiles. Strains of Clostridium botulinum were distinguished from C. sporogenes on the basis of the ratio of two GLC peaks which corresponded to arabinose and glucose. A peak with a retention time identical to that of mannose was present in all C. bifermentans strains but was absent in those of C. sordellii. PMID- 4318576 TI - Plaque morphology of some South American strains of foot-and-mouth disease virus and the effects of polyionic compounds on plaque formation. PMID- 4318578 TI - Foot-and-mouth disease virus: biological characteristics of virus from bovine carriers. PMID- 4318577 TI - Interaction between DEAE-dextran and nucleic acids. II. Effect on interferon production in vivo. PMID- 4318580 TI - Growth characteristics of equine infectious anemia virus in horse leukocyte cultures. Brief report. PMID- 4318579 TI - Stimulatory and inhibitory effects of adenovirus and SV40 on various virus-cell systems. PMID- 4318581 TI - The superinfection of abortively infected monkey kidney cells with SV40. Brief report. PMID- 4318582 TI - Glycoenzymes: a note on the role for the carbohydrate moieties. PMID- 4318584 TI - Preparation of thyroid plasma membranes containing a TSH-responsive adenyl cyclase. PMID- 4318583 TI - NMR studies of the interaction of eserine and atropine with acetylchol inesterase. PMID- 4318585 TI - Platelet phosphorylase activity in the presence of activators and inhibitors of aggregation. PMID- 4318586 TI - Cyclic phosphodiesterase activity and the action of papaverine. PMID- 4318587 TI - Transient repression by AMP in Escherichia coli. PMID- 4318588 TI - The Mn2plus-alkaline phosphatase of E. coli. PMID- 4318589 TI - Capsid proteins of Simian virus 40. PMID- 4318590 TI - Rho-nitrophenyl phosphatase activity in the microsomal fraction of turtle bladder mucosal cells. PMID- 4318591 TI - Glycoproteins of mouse liver smooth microsomal and plasma membrane fractions. PMID- 4318592 TI - Subcellular distribution of thiamine pyrophosphatase in rat cerebral cortex. PMID- 4318594 TI - Cyclic nucleotide-dependent protein kinases. VII. Comparison of various histones as substrates for adenosine 3',5'-monophosphate-dependent and guanosine 3',5' monophosphate-dependent protein kinases. PMID- 4318593 TI - Involvement of hydrophobic and hydrophilic groups of phospholipids in membrane formation. PMID- 4318595 TI - The effects of mercury and other reagents on phosphoglycerate mutase-2,3 diphosphoglycerate phosphatase from kidney, muscle and other tissues. PMID- 4318596 TI - Stereochemistry of glyoxylate oxidation by NAD and mammalian lactate dehydrogenase. PMID- 4318597 TI - Reaction sequence of the K plus-dependent phosphatase. PMID- 4318598 TI - Allosteric control of a Lactobacillus malate dehydrogenase (decarboxylating) by two glycolytic intermediate products. PMID- 4318599 TI - Properties of xanthine oxidase preparations dependent on the proportions of active and inactivated enzyme. PMID- 4318600 TI - [Animal experiments on the etiology of pigmented villonodular synovialitis]. PMID- 4318601 TI - [Fetal-type anomalies of the isoenzymes of aldolase and lactic dehydrogenase in ascitic hepatomas]. PMID- 4318602 TI - Radioimmunoassay of the components of the renin-angiotensin system. PMID- 4318603 TI - Reappraisal of the toxicology of ethylene glycol. I. Determination of ethylene glycol in biological material by a chemical method. PMID- 4318604 TI - The utilisation of I-dimethylaminonaphthalene-5-sulphonyl chloride for quantitative determination of free amino acids and partial analysis of primary structure of proteins. PMID- 4318605 TI - Fatty acid and long chain base composition of adrenal medulla gangliosides. PMID- 4318606 TI - Renal hypertension in rabbits immunized with angiotensin. II. PMID- 4318607 TI - A micro-method for the enzymatic determination of acetoacetate and 3 hydroxybutyrate in blood and urine. PMID- 4318608 TI - Primary cancer of the liver. Quadrennial review. PMID- 4318609 TI - [Recurrence of tumors after gastric resection for cancer]. PMID- 4318611 TI - [Isolation of enteroviruses from feces]. PMID- 4318610 TI - [Laboratory studies on the problem of epidemic hepatitis. I]. PMID- 4318612 TI - [Studies on the pathogenic characters of adenovirus strains in the pig]. PMID- 4318613 TI - The malignancy of mixed tumors of the parotid gland. A clinicopathological analysis of 70 cases. PMID- 4318614 TI - Stress and cigarette smoke effects on lung mitochondrial phosphorylation. PMID- 4318615 TI - Further characterization of the specificity of lung-reactive antibodies in human serum. PMID- 4318617 TI - Partial purification of RNA synthetase obtained from poliovirus-infected HEp-2 cells. PMID- 4318616 TI - Polyribosomes of cells abortively or productively infected with adenovirus, papovavirus, or their hybrid. PMID- 4318618 TI - [Inhibition of giant cell formation with the so-called Compound 48-80 after infection with Herpesvirus hominis]. PMID- 4318619 TI - Limitations of the polymer two phase system for detection of viruses. PMID- 4318620 TI - Effect of beta-propiolactone, ultraviolet irradiation, and formalin on sendai virus cell-fusion factor. PMID- 4318621 TI - A slow sedimenting infective component in vesicular stomatitis virus. PMID- 4318622 TI - [In vitro characteristics of largely genetically homogenous influenza virus A2 strains]. PMID- 4318623 TI - Sendai virus RNA as messenger RNA determining the synthesis of early virus specific proteins. PMID- 4318624 TI - Immunochemical studies of foot-and-mouth disease. VII. Characterization of foot and-mouth disease virus concentrated by polyethylene glycol precipitation. PMID- 4318625 TI - Organ cultures in evaluation of antiviral drugs. I. Virus infection in trachea explants as potential model systems for evaluation of antiviral drugs against respiratory viruses. PMID- 4318626 TI - Sensitivity of baby hamster kidney (BHK 21-C 13) cells to enteric viruses. Brief report. PMID- 4318627 TI - Further characterization of bovine enteroviruses isolated in Poland. Brief report. PMID- 4318628 TI - [EPR spectra of lyophilized irradiated micro-organisms]. PMID- 4318629 TI - [Study of conformational transitions in biomembranes by a weakly bound paramagnetic probe]. PMID- 4318631 TI - The nasopharyngeal angiofibroma. PMID- 4318630 TI - [Postural tonus of the cat during sleep]. PMID- 4318632 TI - A proposed structure and active site of angiotensin. PMID- 4318633 TI - On the possible role of crystals in the origins of life. 3. The phosphorylation of adenosine to AMP by apatite. PMID- 4318634 TI - On the possible role of crystals in the origins of life. IV. The phosphorylation of nucleotides. PMID- 4318635 TI - The role of the intramural nervous system in correlating the spike activity between the stomach and the duodenum. PMID- 4318636 TI - Eosinophil leukocyte responses and hypersensitivity reactions in the Bordetella pertussis-treated mouse. PMID- 4318637 TI - Enzyme histochemistry of the Hofbauer cells of the human placenta. PMID- 4318638 TI - Primary hypogonadotrophic hypogonadism in women. PMID- 4318639 TI - Interaction of ascorbic acid with silicic acid. PMID- 4318640 TI - Virus particles (leukosis-sarcoma group like viruses) in the peripheral nerve and the skeletal muscle tissues with Marek's disease (fowl paralysis). PMID- 4318641 TI - [Frequency and age distribution of Epstein-Barr antivirus antibodies in France. Preliminary sero-epidemiologic survey]. PMID- 4318642 TI - [Sero-epidemiologic study of EB herpes virus in France: frequency and age distribution of antibodies in Parisian region]. PMID- 4318644 TI - [Chemodectoma: tumor of the carotid glomus]. PMID- 4318643 TI - [Lipo-mobilizing factor of pituitary origin]. PMID- 4318645 TI - [Myositis ossificans with arthrogryposis]. PMID- 4318646 TI - Effects of phenothiazine tranquillizers on lysosomes in cultured human cells. PMID- 4318647 TI - [Biological mobilization of potassium from potassium containing alumosilicates. II]. PMID- 4318649 TI - 2,4-dinitrophenol and oxidation of substrates by rat liver mitochondria. PMID- 4318648 TI - Circulation in aves. PMID- 4318650 TI - Effects of thirst on the sleep cycle. PMID- 4318651 TI - Composition of cerebral lipids in murine leucodystrophy: the quaking mutant. PMID- 4318652 TI - Rapidly-labelled, acidic phospholipids of the goldfish brain. PMID- 4318654 TI - Demonstration of an astrocyte-specific cerebroprotein by an immunofluorescence study of human brain tumors. PMID- 4318653 TI - Pattern of RNA synthesis in rabbit cortex during sleep. PMID- 4318655 TI - Effect of fructose on alcohol concentrations in the blood in man. PMID- 4318657 TI - [The clinical picture of cylindromas]. PMID- 4318656 TI - Evaluation, diagnosis, and treatment of clinical conditions related to sleep. PMID- 4318659 TI - [Immunologically and biologically active cellular components of Bordetella pertussis]. PMID- 4318658 TI - [Ultrastructural modifications of the consecutive retina by an atrophy due to optic nerve compression]. PMID- 4318660 TI - The effect of clofibrate on rat tissue adenyl cyclase. PMID- 4318661 TI - Effects of dimethylsulfoxide on normal and burned dog skin. PMID- 4318662 TI - Pressor activity of circulating blood after focal infarction of the kidney in the rat. PMID- 4318663 TI - Demonstration of a circulating factor regulating blood platelet production using 35S-sulfate in rats and mice. PMID- 4318664 TI - Cyclic AMP-mediated stimulation of thymocyte proliferation by low concentrations of cortisol. PMID- 4318665 TI - Lack of increased renin-angiotensin activity in rats with spontaneous hypertension. PMID- 4318666 TI - Characterization of four new rhinovirus serotypes. PMID- 4318667 TI - Adenovirus-associated viruses: enhancement by human herpesviruses. PMID- 4318668 TI - Cyclic AMP effects on antibody formation and their similarities to hormone mediated events. PMID- 4318669 TI - [Present and future in plastic cavity filling materials]. PMID- 4318671 TI - Electrophysiological abnormalities in metabolic myopathies and neuropathies. PMID- 4318670 TI - Metabolic neuropathies and myopathies in adults. Clinical aspects. PMID- 4318672 TI - Abnormal vibratory perception during ischaemia in patients with diabetes mellitus, uraemia or pernicious anaemia. PMID- 4318673 TI - Neurological sequelae of partial gastrectomy. PMID- 4318674 TI - Polyneuropathy in patients with uraemia treated with dialysis. PMID- 4318675 TI - Recovery from peripheral neuropathy after renal transplantation. PMID- 4318676 TI - Adrenocortical secretion capacity during long-term corticotrophin treatment of neurological patients. PMID- 4318677 TI - Toxic effects of water-soluble contrast media for myelography. A polygraphic study in rabbits. PMID- 4318678 TI - Aspiration biopsy diagnosis of neurogenous mediastinal tumours. PMID- 4318679 TI - Granular cell myoblastoma of the cecum: case report. PMID- 4318680 TI - Adenoid cystic carcinoma of breast: report of a case and review of the literature. PMID- 4318681 TI - Enzyme histochemical observations of adenoid cystic carcinoma. "A report of 4 cases and their histochemical findings". PMID- 4318682 TI - [Electric interaction of parallel nonmyelinized nerve fibers. I. Change in the excitability of an adjacent fiber]. PMID- 4318683 TI - [Nature of paramagnetic centers and their photochemical transformations in a monocrystal of L-tyrosine hydrochloride irradiated at 77 degrees K]. PMID- 4318684 TI - [General theory of excitation conduction in a medium]. PMID- 4318685 TI - [Computer modelling of the behavior of nerve fiber membranes under rhythmic stimulation]. PMID- 4318686 TI - [Analysis of the work of autooscillating neuron combinations]. PMID- 4318687 TI - [Sensitized photooxidation of amino acids in frozen solutions]. PMID- 4318688 TI - [Optical study of the change in the structure of nerve membrane during nerve impulse propagation]. PMID- 4318689 TI - [Radiometric method of assessing glucose-6-phosphatase activity]. PMID- 4318690 TI - [Effect of removal of the pancreas and of choline acetylase inhibitors on the post-tetanic potentiation of neuromuscular transmission]. PMID- 4318691 TI - [Role of disintegrating agents in the reproduction of viruses]. PMID- 4318692 TI - [Aging and virus production of cells transformed by polyoma virus]. PMID- 4318693 TI - Alcoholics: their treatment and their wives. PMID- 4318694 TI - Studies on the mechanism of template stability: cytoplasmic DNA-like RNA in hepatocellular carcinomas. PMID- 4318696 TI - Ultrastructural features of invasion in chick embryo liver metastasis of Yoshida ascites hepatoma. PMID- 4318695 TI - Age dependence of immunologically induced central nervous system disease in C58 mice. PMID- 4318697 TI - Established lines of SV40-transformed human amnion cells. PMID- 4318698 TI - Light and electron microscope studies of osteosarcomas induced in rats and hamsters by Harvey and Moloney sarcoma viruses. PMID- 4318699 TI - Differential growth of hepatoma-susceptible liver induced by gene X genome interaction. PMID- 4318700 TI - Genetic influences on response to castration of liver growth and hepatoma formation. PMID- 4318701 TI - An electron microscope study of intranuclear canaliculi in Novikoff hepatoma cells. PMID- 4318702 TI - Claude's chicken tumor virus-10: local variability in virus titer and effect of amputation. PMID- 4318703 TI - Thyroid hormone regulation of mitochondrial alpha-glycerophosphate dehydrogenase in liver and hepatoma. PMID- 4318704 TI - Simian papovavirus 40 transformation of cells from cancer patient with XY-XXY mosaic Klinefelter's syndrome. PMID- 4318705 TI - Effect of partial hepatectomy on tumor incidence in BALB-c mice treated with urethan. PMID- 4318706 TI - Ultrastructural and biochemical changes associated with pyrrolizidine-induced hepatic megalocytosis. PMID- 4318707 TI - The distribution and synthesis of DNA in two classes or rat liver nuclei during azo dye-induced hepatocarcinogenesis. PMID- 4318708 TI - Enzymes, nucleic acids, and lipids in human breast cancer and normal breast tissue. PMID- 4318709 TI - [Monoamine oxidase activity of nuclear membranes of liver and ascites hepatoma cells]. PMID- 4318710 TI - [Effect of vitamin D3 on calcification of bone tissue of chicks in experiments in vitro]. PMID- 4318711 TI - [Reactions of the spinothalamic neurons of the posterior ventral nucleus of the thalmus]. PMID- 4318712 TI - [Detection of viral antigens in aphthous and herpetic mouth diseases]. PMID- 4318713 TI - [Tetracosactid delay in the treatment of bronchial asthma]. PMID- 4318714 TI - [ACTH allergy--its prevention]. PMID- 4318715 TI - Vascular reactivity and mechanical properties of normal and cadmium-hypertensive rabbits. PMID- 4318716 TI - Influence of prior storage on pyridine nucleotide metabolism of human erythrocytes incubated in vitro. PMID- 4318717 TI - Spontaneous and evoked activity of motor nerve endings in calcium Ringer. AB - 1. Electrical activity of neuromuscular junctions of the frog was studied in a medium (Ca-Ringer) whose Na ions had been entirely replaced by Ca.2. Spontaneous miniature end-plate potentials (m.e.p.p.s) of reduced amplitude are recorded in this abnormal ionic environment, and graded end-plate potentials can be elicited by applying depolarizing current pulses to the pre-junctional parts of the nerve.3. Addition of 5 mM tetraethylammonium (TEA) to the Ca-Ringer causes the appearance, in almost all-or-none fashion, of very large e.p.p.s (up to 45 mV in amplitude) in response to nerve stimulation.4. These ;giant' e.p.p.s occur despite the curarizing action of TEA (and its depressing effect on the amplitude of m.e.p.p.s) and they persist after application of tetrodotoxin.5. After several hours exposure to Ca-Ringer, spontaneous end-plate activity gradually declines, and eventually evoked e.p.p. responses fail. On return to normal Na-Ringer, spontaneous end-plate activity is quickly resumed, but the potentials have an abnormal, very wide, amplitude distribution.6. The results are discussed, in conjunction with relevant work on the squid giant synapse, in terms of the ;calcium hypothesis' of transmitter release. PMID- 4318718 TI - Differential effects of chlorpromazine and phenobarbital on EEG sleep patterns. PMID- 4318719 TI - The behavioral effects of amphetamine on REM deprived rats. PMID- 4318720 TI - Effects of intra-uterine and oral contraceptives on the ultrastructure of the human endometrium. PMID- 4318721 TI - Electronic structures for energy-rich phosphates. PMID- 4318722 TI - Effect of various liver diseases on total urinary corticoid excretion. PMID- 4318723 TI - [Diagnosis of renal hypertension]. PMID- 4318724 TI - The Stepping Stone Club. PMID- 4318725 TI - Renal tumors. PMID- 4318726 TI - Immunology and cancer. PMID- 4318728 TI - Systemic chemotherapy 1968. PMID- 4318727 TI - Angiography in the diagnosis of gastrointestinal cancer. PMID- 4318729 TI - The role of radiation therapy in the management of soft somatic tissue sarcoma. PMID- 4318730 TI - Synovial sarcoma. PMID- 4318731 TI - [Case of keratoacanthoma on the lower lip]. PMID- 4318732 TI - Symposium on certain forms of infective kerato-uveitis or uveitis. I. An approach to the problem, and the technique of anterior chamber tap. PMID- 4318733 TI - Herpetic kerato-uveitis with herpes virus antigen in the anterior chamber. PMID- 4318735 TI - [Methodology of enzymatic triglyceride determination in the serum]. PMID- 4318736 TI - [Enzymatic determination of adenosine-5'-monophosphate in blood]. PMID- 4318734 TI - [Biochemistry of normal and leukemic white blood cells]. PMID- 4318737 TI - [Glomus tumor of the soft palate]. PMID- 4318738 TI - [Contrast roentgenography in diseases of maxillary and frontal sinuses]. PMID- 4318739 TI - [The question of multiple otogenic abscesses of the brain]. PMID- 4318740 TI - Further studies on the 27S and 32S optical density peaks of the rat thyroid. PMID- 4318741 TI - Excretion patterns of 17-ketosteroids and 17-hydroxycorticosteroids in surgical stress. PMID- 4318742 TI - Neutral steroids in urine during pregnancy. I. Isolation and identification of dihydroxylated C19 and C21 steroid disulphates. PMID- 4318743 TI - Catecholamines and metabolism of human adipose tissue. 3. Comparison between the regulation of lipolysis in omental and subcutaneous adipose tissue. PMID- 4318744 TI - Catecholamines and metabolism of human adipose tissue. IV. Influence of glucose on catecholamine induced lipolysis in human omental adipose tissue in vitro. PMID- 4318745 TI - Catecholamines and metabolism of human adipose tissue. V. Studies on the incorporation of glucose-1-14C into lipids and the re-esterification of FFA by human omental tissue in vitro. PMID- 4318746 TI - Influence of prostaglandin E1 on lipolysis induced by noradrenaline, isopropylnoradrenaline, theophylline, and dibutyryl cAMP in human omental adipose tissue in vitro. PMID- 4318747 TI - Fat mobilizing lipolysis and levels of cyclic AMP in human and dog adipose tissue. PMID- 4318748 TI - Juvenile nasopharyngeal angiofibroma. A clinical study of 69 cases. PMID- 4318749 TI - Etiologic and clinical aspects of acute respiratory diseases in children. PMID- 4318750 TI - Detection of sugars and sugar derivatives by perchloric acid on cellulose thin layers. PMID- 4318751 TI - Chelation in experimental Pseudomonas keratitis. PMID- 4318752 TI - Sulfamylon acetate in the treatment of pseudomonas pyocyanea infection of burns. PMID- 4318753 TI - Survival after liver resection for cancer. PMID- 4318754 TI - Chemotherapy of breast cancer by regional intra-arterial infusion. PMID- 4318755 TI - Clinical and pathologic staging as a guide in the management of Wilms' tumor. PMID- 4318756 TI - Paget's disease of the breast. PMID- 4318757 TI - [Role of hormone in blood pressure control]. PMID- 4318759 TI - [Variation in plasma cortisol level during the rapid beta-1-24 corticotropin (synthetic ACTH) test with a single intravenous injection of beta-1-24 corticotropin]. PMID- 4318758 TI - [Endocrine function tests for etiological diagnosis of hypertensive patients]. PMID- 4318760 TI - [Adrenal hirsutism (3-beta-hydroxysteroid dehydrogenase deficiency). Chromatographic separation of the urinary 17-ketosteroid fraction. 3. Differential diagnosis of adrenal hirsutism (Cushing congenital adrenogenital syndrome)]. PMID- 4318761 TI - Adrenocortical insufficiency in spite of high corticosteroid excretion in a patient with thyrotoxicosis. PMID- 4318764 TI - Some steroid pyrophosphates. PMID- 4318763 TI - Studies on phosphate hydrolyzing activities in the synaptic membrane. PMID- 4318762 TI - [Coincidence between nephrocalcitopotropic and estrogenic efficacy of some anabolic agents, androgens, gestagens and estrogens]. PMID- 4318765 TI - Polymorphonuclear leukocyte motility in vitro. V. Release of chemotactic activity following phagocytosis of calcium pyrophosphate crystals, diamond dust, and urate crystals. PMID- 4318766 TI - A reduced nicotinamide adenine dinucleotide--linked kinetic assay for adenosine deaminase activity. PMID- 4318767 TI - Studies on polypeptides. XLVI. Synthesis of a stably labeled, biologically active adrenocorticotropin fragment. PMID- 4318768 TI - Steroidal heterocycles. 13. 4alpha,5-Epoxy-5alpha-androst-2-eno[2,3-d]isoxazoles and related compounds. PMID- 4318769 TI - The effect of oral contraceptives on the histology of carcinoma of the breast. PMID- 4318770 TI - [Condensation of kinins by silica gel]. PMID- 4318771 TI - [Subacute peripheral neuropathy involving the cranial nerves in a young female alcoholic with acute pulmonary tuberculosis]. PMID- 4318772 TI - [Recurrent complex neuropathy with pleiocytosis and high level of cerebrospinal fluid albumin during development of cryptoleukosis: anatomo-clinical case]. PMID- 4318773 TI - DNA polymerase activity associated with RNA tumor viruses. AB - C-type RNA viruses, originating in mouse, cat, hamster, and viper, catalyze the synthesis of DNA from its constituent deoxyribonucleoside triphosphates. Both the rate and extent of the reaction were significantly enhanced by brief treatment of the intact virus with ether. A proportion of the newly synthesized DNA was associated with virions when intact virus was used as template; this was not the case with ether-treated virus. In both cases, DNA extracted from the reaction mixture sedimented slowly, at about 2-4 S. PMID- 4318774 TI - Identification of proinsulin and C-peptide in human serum by a specific immunoassay. AB - An immunoassay for the measurement of human proinsulin and C-peptide is described. By a combination of this system and an insulin immunoassay, proinsulin, insulin, and C-peptide were identified in acid-ethanol extracts of serum after gel filtration. In keeping with the results of biosynthetic studies, insulin and C-peptide were found to be present in equimolar amounts. The absolute values of serum proinsulin determined independently in the two assays corresponded closely. PMID- 4318775 TI - Electron paramagnetic resonance study of the high- and low-spin forms of cytochrome P-450 in liver and in liver microsomes from a methylcholanthrene treated rabbit. AB - The high- and low-spin forms of cytochrome P-450 were observed by electron paramagnetic resonance (epr) in a liver slice and in hepatic microsomes from a rabbit injected with methylcholanthrene. Quantitation of the epr absorption of these two chemical species and comparison with a preparation from a control rabbit showed that the single injection of drug increased the concentration of cytochrome P-450 to more than ten times its control value. Analysis of the epr spectrum for the high-spin compound showed that it is the most rhombically distorted ferric heme iron site yet observed (E/D = 0.10). It is suggested that microsomal cytochrome P-450 can exist in two interconvertible forms, in which the heme iron can either be high-spin or low-spin, depending upon the nature of the nonporphyrin ligands of the metal. There seems to be no need to postulate the existence of two different cytochrome P-450 proteins. PMID- 4318776 TI - Specific aggregation of SV40-transformed cells by ornithine, leucine copolymers. AB - A basic copolymer of ornithine and leucine (1:1) was shown to rapidly agglutinate, in the absence of serum, normal cells and cells transformed by viral and nonviral carcinogens. This agglutination was inhibited by addition of serum. In presence of serum, the same copolymer and those of ornithine and valine (1:1) and arginine and leucine (1:1), produced a specific aggregation of simian virus 40 (SV40)-transformed cells cultured for about 24 hr after addition of the peptide. The rapid agglutination and SV40-specific aggregation could not be inhibited by a variety of individual amino acids or carbohydrates. The specific aggregation could be detected in mixtures of SV40-transformed and other cells, and it was not prevented by x-irradiating the cells with 4000 R. Aggregation of the SV40-transformed cells was inhibited by acidic polyamino acids provided these were added not later than about 5 hr after addition of the basic copolymer. The results indicate that the basic copolymer, in the presence of serum, produces a change in SV40-transformed cells, presumably in the surface membrane, that causes the cells to aggregate. In addition to the aggregation of cells transformed by SV40, cells transformed by adenovirus 12, which did not contain detectable SV40 specific nuclear tumor (T) antigen, were also aggregated by the basic copolymer in the presence of serum. This indicates that the ornithine, leucine copolymer is able to detect an SV40-like change in the surface membrane of cells transformed by adenovirus 12. PMID- 4318777 TI - Antigenic study of unfertilized mouse eggs: cross reactivity with SV40-induced antigens. AB - Serum obtained from guinea pigs immunized with unfertilized C57BL/6 mouse eggs was found to be cytotoxic in the presence of complement for eggs obtained from syngeneic and allogeneic mice. The anti-egg serum was not cytotoxic for rat eggs, lymph node cells, methylcholanthrene-induced tumor cells, or 3T3 cells obtained either from syngeneic or allogeneic mice. The anti-egg serum was, however, cytotoxic for SV40-transformed 3T3 cells and C57BL/6 cells. After absorption with SV40-transformed cells, anti-egg serum lost its cytotoxicity for mouse eggs. PMID- 4318779 TI - Immunofluorescent detection of herpesvirus antigens in exfoliated cells from human cervical carcinoma. AB - Exfoliated cells from patients with squamous carcinoma of the cervix contain antigens related to herpesvirus subtype 2, as revealed by direct or indirect immunofluorescent techniques. Normal squamous cells from the same subjects and from controls without the disease, and cells from a small number of tumors at sites other than the cervix, did not react with anti-herpesvirus subtype 2 serum. Antisera to adenovirus 18 or mycoplasma orale did not react with the exfoliated cells. PMID- 4318778 TI - Effects of heat treatment of electron-transport particles on bacterial oxidative phosphorylation. AB - The electron-transport particles from Mycobacterium phlei exhibit low levels of phosphorylation unless supplemented with soluble coupling proteins. Heat treatment of the electron transport particles for 15 min at 50 degrees C was found to result in a slight loss of oxidation and an activation of phosphorylation with NADH as substrate, while with succinate as substrate both activities increased. The heat-activated particles do not require the addition of soluble coupling factors and their level of oxidative phosphorylation is similar to that of the regular particles supplemented with the soluble coupling factors. In contrast to the lack of a requirement for the soluble coupling factors after heat activation, the heat-treated electron-transport particles require the presence of a particulate-bound coupling factor for phosphorylation. The heat activated system, like the untreated system, was found to be sensitive to uncoupling agents. PMID- 4318780 TI - ATP-dependent and cyclic AMP-dependent activation of rat adipose tissue lipase by protein kinase from rabbit skeletal muscle. AB - Brief incubation of partially purified preparations of hormone-sensitive lipase from rat epididymal fat pads with ATP, Mg(++), cyclic adenosine 3':5' monophosphate and rabbit muscle protein kinase (phosphorylase b kinase kinase) resulted in enhancement of lipolytic activity (44-93%). Little or no activation was observed when either the cofactor mixture or the protein kinase was omitted. When the fat pads were incubated with epinephrine prior to homogenization, addition of kinase and cofactors to the soluble supernatant fraction caused no activation whereas good activation was obtained in preparations from paired fat pads not exposed to epinephrine. The results indicate that the cyclic AMP mediated activation of hormone-sensitive lipase in adipose tissue involves a protein phosphorylation step. Whether the lipase itself is phosphorylated and thus activated or whether the protein kinase is activating a mediating enzyme, in analogy with its action in the glycogen phosphorylase system, remains to be determined. PMID- 4318781 TI - A protein binding assay for adenosine 3':5'-cyclic monophosphate. AB - A simple and sensitive assay for adenosine 3':5'-cyclic monophosphate (cAMP) has been developed that is based on competition for protein binding of the nucleotide, presumably to a cAMP-dependent protein kinase. The nucleotide-protein complex is adsorbed on a cellulose ester filter. Assay conditions are such that a binding constant approaching 10(-9) M is obtained, and the assay is thus sensitive to 0.05-0.10 pmol of cAMP. PMID- 4318783 TI - Group-specific antigen expression during embryogenesis of the genome of the C type RNA tumor virus: implications for ontogenesis and oncogenesis. AB - Tests for the group-specific antigen of the C-type RNA tumor virus showed that mouse embryos of all strains tested, at some stage of development in utero, revealed detectable titers of group-specific antigen in one or more of their tissues; younger, rather than older, embryos were likely to be positive, particularly in those strains which normally reveal little or no expression of the RNA genome postnatally. The antigens were found in embryos of low-leukemia strains, free of infectious virus. These new findings support a previously stated hypothesis that the genome of RNA tumor viruses, mostly switched off for infectious virus expression, is vertically transmitted as part of the natural genetic apparatus of normal mouse cells. Since group-specific antigens have also been described in chick embryos and immunological tolerance to homologous group specific antigens has been demonstrated in hamsters and cats as well as in mice and chickens, the hypothesis has been extended to include vertebrate cells in general. Finally, the high incidence and titers of the group-specific antigen suggest that the genes for RNA tumor virus, which later in life act as determinants of cancer, may be important also as gene determinants in the developing embryo. PMID- 4318782 TI - Conversion of glycogen phosphorylase b to a by non-activated phosphorylase b kinase: an in vitro model of the mechanism of increase in phosphorylase a activity with muscle contraction. AB - Phosphorylase b kinase activity, as present in resting muscle in the non activated form, appears to be ample to account for the fast appearance of phosphorylase a observed with muscle contraction. The kinase activity is repressed by free ATP and stimulated by free Mg(2+). Phosphorylase b kinase activity increases greatly when the Mg(2+):ATP ration exceeds 1. It is proposed that the breakdown of ATP that occurs during muscle contraction may represent the triggering factor for the observed in vivo conversion of phosphorylase b into a. PMID- 4318784 TI - Genetic transmission of viruses that incite mammary tumor in mice. AB - Electron microscopy, immunofluorescence, and bioassay demonstrated the presence of a mammary tumor inciting virus in untreated mice of three different inbred strains, and in irradiated or urethan-treated mice of two other mouse strains, indicating the ubiquitous nature of this group of viruses. In general these viruses are transmitted vertically by the gametes of the mouse strain in which they naturally occur. The virus is present in every cell, although often in an incomplete form. If a mammary tumor inciting virus is introduced into a different mouse strain, only milkborne transmission will take place, after which the virus is found in a limited number of tissues. It has been speculated that mammary tumor inciting viruses are transmitted as genetic factors of the host strain to which they belong. There is some evidence that a repressor, produced by a regulator gene, controls the rate of release of such a genetically transferred virus. Repression can be abrogated by a carcinogenic treatment. The repressor would also cause resistance to a superinfecting mammary tumor inciting virus by interference with its replication. PMID- 4318785 TI - DNA and gene therapy: uncoating of polyoma pseudovirus in mouse embryo cells. AB - Pseudovirions (host DNA fragments encapsidated by polyoma virus-coat protein) and polyoma virions are produced after infection of primary mouse embryo cells with polyoma virus. Purified pseudovirions are adsorbed to, and uncoated by, mouse embryo cells. The evidence for this uncoating is based on the conversion by pancreatic DNase of the uncoated pseudovirus DNA from an acid-insoluble to an acid-soluble form. The implications of these experiments to the eventual use of DNA for gene therapy are discussed. PMID- 4318786 TI - Mechanism of carcinogenesis by RNA tumor viruses. I. An RNA-dependent DNA polymerase in murine sarcoma viruses. AB - A highly active and stable DNA polymerase was found in purified preparations of two murine sarcoma viruses. Enzyme activity is not detected in most virus preparations unless they are treated with low concentrations of a nonionic detergent such as Nonidet P-40. The incorporation of labeled thymidine triphosphate requires all four deoxyribonucleoside triphosphates and either Mg(2+) or Mn(2+). Enzyme activity is proportional to virus concentration and is linear with time up to 90 min. That the template is RNA is suggested by the reduction in polymerase activity upon treatment of murine sarcoma virus with RNase, and by the absence of detectable amounts of DNA in the virus. That the product is DNA is shown by the incorporation of all four deoxyribo-nucleoside triphosphates into an acid-insoluble product which is stable in alkali, is destroyed by DNase, sediments in alkaline sucrose gradients with a sedimentation coefficient of 7 S, and bands in isopycnic CsCl gradients with a mean buoyant density of 1.700. PMID- 4318787 TI - Host range mutants of polyoma virus. AB - A line of polyoma-transformed mouse cells has been isolated which is fully susceptible to lytic infection by polyoma virus. This line has been used to select virus mutants which have lost most or all of their ability to grow in the untransformed parental line while retaining the ability to grow in the transformed derivative. These virus mutants are also defective in their ability to transform cells of rat or hamster origin. Since the DNA extracted from the mutants has the same host range as the whole virus, the mutants appear to be blocked at some intracellular step which is required both for the completion of virus development in mouse cells and for transformation in rat or hamster cells. PMID- 4318788 TI - Mechanism of activation by adenosine 3':5'-cyclic monophosphate of a protein phosphokinase from rabbit reticulocytes. AB - Two protein phosphokinases (EC 2.7.1.37) were found to be present in rabbit reticulocytes. The two enzymes were separated by DEAE-cellulose chromatography and called kinases I and II. Adenosien 3':5'-cyclic monophosphate stimulated the activity of both enzymes. However, the degree of stimulation was different and depended on the protein acceptor used. In the presence of adenosine 3':5'-cyclic monophosphate, protein kinase I dissociated into two subunits: a subunit binding adenosine 3':5'-cyclic monophosphate, and a catalytic subunit. The component binding the cyclic nucleotide appeared to act as an inhibitory protein, regulating the activity of the catalytic subunit. The mechanism of action of the cyclic nucleotide on kinase II appeared to be different from that of kinase I. PMID- 4318789 TI - Possible role of pyrophosphate linkage in the active transport of sodium ions. AB - Based upon the observation that the pyrophosphate group has a greater affinity for sodium ion than for potassium ion, and that both of these ions catalyze transphosphorylation, a simple molecular mechanism is formulated for the active transport of sodium ions across biological membranes. It is assumed that the active transport takes place along a chain of phosphomonoester groups in the membrane. Pyrophosphate linkages are synthesized at the inner boundary of the membrane by a sodium-activated kinase and hydrolyzed at the outer boundary of the membrane by a potassium-activated pyrophosphatase. It is shown that in such a model the pyrophosphate linkages can diffuse across the membrane and carry sodium ions in the direction of increasing sodium ion concentration. PMID- 4318790 TI - Alcohol and adrenocortical function. Negative effect on ACTH reserve in man by metyrapone test. PMID- 4318791 TI - Influence of ethanol on the redox state of the liver. PMID- 4318792 TI - [Laparographic aspects of Krukenberg's tumor]. PMID- 4318793 TI - [Induction of DNA synthesis and mitosis under the action of the polyoma virus on cell cultures at stationary phases of growth]. PMID- 4318794 TI - [Clinical studies of urinary 17-OHCS fraction in children. 2. ACTH test and metopirone test in healthy children and children with endocrinological diseases]. PMID- 4318795 TI - Cytomegalovirus in children. PMID- 4318796 TI - Histochemical comparisons of enzymes in craniopharingioma and ameloblastoma. PMID- 4318797 TI - [Histoenzymological test in vitro of the role of glucose in the regulation of glucose-6-phosphatase activity in beta cells of the islets of Langerhans]. PMID- 4318799 TI - [Variations of the CRF and corticotropin activities of the hypothalamus after hypophysectomy in rats]. PMID- 4318798 TI - Total pancreatectomy. PMID- 4318800 TI - Ultrastructural manifestations of pituitary release of ACTH in the rat. PMID- 4318801 TI - [Some facts of enzymatic embryology]. PMID- 4318803 TI - Mechanism of inactivation of erythrocyte membrane adenosine triphosphatase by carbodiimides. PMID- 4318802 TI - Purification and properties of an acid nucleoside triphosphatase from rat liver mitochondria. PMID- 4318804 TI - Absolute configuration of the carboxyethyl (lactyl) side chain of muramic acid [2 amino-3-O-(D-1 carboxyethyl)-2-deoxy-D-glucose]. PMID- 4318805 TI - An assay for adenosine 3',5'-cyclic monophosphate based on the association of the nucleotide with a partially purified binding protein. PMID- 4318806 TI - [On the possible intervention of natriuretic factors of adrenal origin in conditions of deficiency of renal plasmatic flow]. PMID- 4318807 TI - [On the minimal effective erythrostimulating doses of ACTH, hydrocortisone and prednisolone]. PMID- 4318808 TI - [Correlation between blood lipids and peripheral neuropathy in juvenile and adult diabetics]. PMID- 4318810 TI - [Differential solubilization of acid hydrolases of the rat liver]. PMID- 4318809 TI - [Action of detergents on G-6-P phosphohydrolase, pyrophosphatase and PPi-glucose phosphotransferase in the liver of hyperthyroid rats]. PMID- 4318811 TI - [Fluphenazine oenanthate in post-hospital treatment]. PMID- 4318812 TI - Temporal course of synaptic degeneration in the lateral geniculate nucleus. Its dependence on axonal stump length. PMID- 4318813 TI - Immunological studies with cell cultured aluminium hydroxide gel adsorbed formalin inactivated foot and mouth disease type Asia I monovalent vaccine. PMID- 4318814 TI - The incidence of complement-fixing antibody to varicella-zoster virus in hospital patients and blood donors. AB - The sera of 308 patients, not suffering from varicella or zoster infections, and the sera of 183 blood donors were examined for complement-fixing antibody to varicella-zoster virus. In both groups about 70% of sera from persons aged 11-40 years had antibody titres >/= 1/4; the incidence was less in the age range 41-60 years and increased in later decades. Antibody titres of 1/16 or 1/32 were noticeably less frequent in those aged 41-60 years than in younger or older groups.It was concluded that an unchanging titre of 1/16 or 1/32 was of no diagnostic significance. The age distribution of antibody was consistent with the theory that zoster only occurs when antibody has declined. PMID- 4318816 TI - Radiological maturity of the small-for-dates fetus. PMID- 4318817 TI - Bilharziasis of the cervix uteri. PMID- 4318815 TI - Serological studies with human papova (wart) virus. AB - Methods for demonstrating antibody to wart virus by complement fixation and passive haemagglutination tests are described and compared with the precipitin test of Almeida & Goffe (1965). The results reveal the much greater sensitivity of the passive haemagglutination method, particularly in the detection of the immunoglobulin M class of antibody. Both complement-fixing and precipitating antibody were detected in sera from patients whose warts had undergone a spontaneous resolution.The presence of antibody to wart virus was demonstrated in sera from persons who had had warts up to 10 years previously, and in a few cases from those who thought they had never had warts.The antigenic identity of virus from hand warts and plantar warts of the simple and mosaic types was revealed, and some evidence was obtained for similar identity of the virus from genital warts. PMID- 4318818 TI - [Anatomical study of peripheral neuropathies of diabetes mellitus]. PMID- 4318819 TI - [Correlation between insular pancreas and the thyroid: new physiological and clinical data]. PMID- 4318820 TI - [Clinical study of peripheral neuropathies in diabetes mellitus]. PMID- 4318821 TI - The respiratory system in cerebral edema. PMID- 4318823 TI - [The tarsal tunnel syndrome. A review]. PMID- 4318822 TI - [Kidney and vitamin E]. PMID- 4318824 TI - [The tarsal tunnel syndrome. Report of 9 cases]. PMID- 4318825 TI - [Role of host genes in infections of animal viruses, with special reference to RNA tumor viruses]. PMID- 4318826 TI - Memory and perception. PMID- 4318827 TI - Hallucinations and dreaming. PMID- 4318828 TI - [The action of growth hormone (H.G.H.) on the phenomenon of placentation in white rats compared with that of ACTH, cortisone and H.C.G]. PMID- 4318829 TI - [Diagnosis and symptoms of parietal lobe tumors]. PMID- 4318830 TI - [Catheter biopsy in peripheral lung lesions]. PMID- 4318831 TI - [Determination of the inhibitory activity of some substituted theophyllines on the phosphodiesterase specific for the adenosine 3'5'-monophosphate]. PMID- 4318832 TI - Calcium and cardiac contractility. PMID- 4318833 TI - Carcinogenesis in rats by aflatoxins B1, G1, and B2. PMID- 4318834 TI - Toxicity, tissue changes, and tumor induction in inbred Swiss mice by methylnitrosamine and -amide compounds. PMID- 4318836 TI - A relation between pyridine nucleotide-dependent dehydrogenase activity and nicotinamide adenine dinucleotide glycohydrolase in Ehrlich ascites tumor cells. PMID- 4318835 TI - Glucuronyltransferase activity in transplantable rat hepatomas. PMID- 4318838 TI - Nuclear protein composition and metabolism of HeLa cells after infection with herpes simplex virus. PMID- 4318839 TI - Partial characterization of the histones and histone acetylation in cell cultures. PMID- 4318837 TI - A rapid method for the isolation of nuclei from Ehrlich ascites tumor cells. PMID- 4318841 TI - Actions of ascorbic acid on hormone induced lypolysis in vitro. PMID- 4318840 TI - A study of surface ionogenic groups of chick embryo cells transformed by Rous sarcoma virus. PMID- 4318842 TI - Formation of helical polyribosomes in poliovirus-infected cells of the 37 RC line. PMID- 4318843 TI - Controlled production of proliferating somatic cell hybrids. AB - The techniques described permit the controlled production of large numbers of proliferating somatic cell hybrids in a relatively short period of time. Sendai virus is used to promote cell hybridization. beta-propriolactone is employed as the inactivating agent of Sendai virus since it produces complete loss of viral infectivity while preserving viral fusion capacity. Cells are fused in monolayer, instead of in suspension, since fixing cells in two dimensions permits one to control cell contacts during the fusion event through the expedient of varying multiplicities of the parental cells and the total cell density. Under the conditions described, a several hundred fold increase in the number of hybrid clones obtained is seen as compared to the controls. PMID- 4318844 TI - The surface charge of rat liver mitochondria and their membranes. Clarification of some controversies concerning mitochondrial structure. AB - The surface charge of intact mitochondria and submitochondrial particles was examined by the technique of preparative free flow electrophoresis. When submitochondrial preparations obtained by a swelling-contraction procedure were examined with this technique, two fractions were observed. One of these fractions exhibited the same electrophoretic properties as intact mitochondria, which indicated that it was derived from the outer limiting membrane of the mitochondrion. This fraction was found to contain the enzymes monoamine oxidase and rotenone-insensitive NADH-cytochrome c reductase which have been reported to be localized in the outer mitochondrial membrane. The other fraction exhibited an electrophoretic mobility which was different from that of intact mitochondria, and this fraction contained enzymes characteristic of the inner membrane-matrix fraction such as soluble and particulate enzymes of the Krebs cycle. Microsomes exhibited an electrophoretic mobility which was almost identical with that of the outer mitochondrial membrane. In addition to resolving the localization of enzymes in mitochondrial membranes, these data indicate that the outer limiting membrane of the mitochondrion is the sole determinant of the surface charge of mitochondria. PMID- 4318845 TI - Behavior of angiotensin octapeptides and dinitrophenyl-angiotensin during chromatography on polyacrylamide and dextran gels. PMID- 4318846 TI - Replication of varicella-zoste virus in cell culture: an ultrastructural study. PMID- 4318847 TI - [Tumors of the endocrine pancreas apropos of a further case of nonfunctional malignant nesidioblastoma of the head of the pancreas treated by duodenopancreatectomy with prolonged survival]. PMID- 4318848 TI - [An interesting case of cytomegaly and mucoviscidoisis]. PMID- 4318849 TI - Stepwise removal of five nucleotides from 5'-half of yeast valine transfer RNA and its acceptor activity. PMID- 4318850 TI - Inhibition of platelet energy production and release reaction by PGE1, theophylline and cAMP. PMID- 4318851 TI - Solvent-induced EPR anisotropy change of the non-heme chromophore of spinach ferredoxin. PMID- 4318852 TI - Ultraviolet light enhanced reactivation of a mammalian virus. PMID- 4318853 TI - Inactivation of the Tu-GTP recognition site in aminoacyl-tRNA by chemical modification of the tRNA. PMID- 4318854 TI - Mechanism of TSH action: effects of dibutyryl cyclic AMP on RNA synthesis in isolated thyroid cells. PMID- 4318855 TI - Optical properties of catalytically active cobalt and cadmium liver alcohol dehydrogenases. PMID- 4318856 TI - Effect of ATP on the redox cycle of respiratory chain-linked DPNH dehydrogenase and the localization of coupling site I. PMID- 4318857 TI - Ribonuclease activity in rat bone marrow nuclei. PMID- 4318858 TI - [Formation of 2-methoxy derivatives by incubation of estrone 6,-7 3H with liver slices of normal hyperthyroid or hypothyroid rats and with rat hepatoma slices]. PMID- 4318859 TI - [Secretion of thyroid hormones by rat thyroid lobes in vitro: effect of thyreostimulin]. PMID- 4318860 TI - [Rapid method of separation under high pressure of phospholipids on a silicic acid column. Application to human bile]. PMID- 4318861 TI - [Chemical carcinogenesis and free radicals]. PMID- 4318862 TI - [Ultrastructural study of mammary tumors in organ-specific culture]. PMID- 4318863 TI - [Potentiation of antiviral action of interferon by actinomycin D]. PMID- 4318864 TI - [Adrenal cortex stimulation and the other effects of synthetic 24 amino acid ACTH]. PMID- 4318865 TI - [The activity of non-specific phosphatases in the blood of patients with periodontal diseases during healing of periodontal wounds]. PMID- 4318867 TI - [Lever's myoepithelioma]. PMID- 4318866 TI - [Cylindromas of the oral cavity. Anatomo-pathological and clinical considerations]. PMID- 4318868 TI - [Ultrastructure of Paget's extramammary disease]. PMID- 4318869 TI - Enzymic condensation of 3-methyl-2-alkenyl pyrophosphates with isopentenyl pyrophosphate. PMID- 4318870 TI - Afferent pathways of stressful stimuli: corticotrophin release after hypothalamic deafferentation. PMID- 4318871 TI - [Experimental studies on sensitivity test of anticancer agents by tissue respiration]. PMID- 4318873 TI - [Immunosuppression produced by viruses]. PMID- 4318872 TI - Disseminated cytomegalic inclusion disease in a burned adult. PMID- 4318875 TI - [Long-term therapy of nephrotic syndrome by administration of synthetic ACTH only -with special reference to variation in pituitary-adrenal functions]. PMID- 4318874 TI - [Current information on angiotensin I-converting enzyme]. PMID- 4318876 TI - [Virilizing tumor of the adrenal]. PMID- 4318877 TI - Pain in the extremities. PMID- 4318878 TI - [High voltage slow waves induced by short--chain fatty acids with special reference to sleep rhythm]. PMID- 4318879 TI - Arteriography in the diagnosis of islet-cell tumors. PMID- 4318880 TI - The efficacy of angiography in the evaluation of glomus tympanicum tumors. PMID- 4318882 TI - [Modification of the complement fixation test in determining the type of foot-and mouth disease virus]. PMID- 4318881 TI - Studies on changes of several enzyme activities and of acute phase reactants in experimental allergic encephalomyelitis. PMID- 4318883 TI - [Isolation and identification of herpesvirus from cattle]. PMID- 4318884 TI - [A study of a virus isolated from cattle with symptoms of diarrhea]. PMID- 4318886 TI - [Para-influenza in cattle]. PMID- 4318885 TI - [Serological properties of 2 strains of swine enterovirus]. PMID- 4318887 TI - [Adrenal gland hyperfunctions]. PMID- 4318888 TI - Stimulation of the human brain. Spontaneous and evoked electroencephalographic responses. PMID- 4318889 TI - An electrical correlate to a permanent increase of antigravity activity. PMID- 4318890 TI - Functional possibilities for communication and coding of neuronal properties and interactions. PMID- 4318891 TI - [Ocular movements during the paradoxical phase of sleep]. PMID- 4318893 TI - Effects of oncotic gradients and enzymes on negative pressures in implanted capsules. PMID- 4318892 TI - Release of renin by rat kidney slices. PMID- 4318894 TI - Digital computer analyzed sleep and resting EEG during haloperidol treatment. PMID- 4318895 TI - The veins of the posterior cranial fossa: an angiographic study under pathologic conditions. PMID- 4318896 TI - False positive brain scan associated with febrile convulsions. PMID- 4318897 TI - [Prognosis of phyllodes tumors of the breast (apropos of 2 malignant cases)]. PMID- 4318898 TI - 21,25-dihydroxycholecalciferol. A metabolite of vitamin D3 preferentially active on bone. PMID- 4318899 TI - The isolation and characterization of sorbitol-6-phosphate dehydrogenase from Clostridium pasteurianum. PMID- 4318901 TI - [Demonstration of virus particles of AMV type in a transplantable hamster tumor: HP]. PMID- 4318900 TI - [Determination, on histologic sections, of specific activities of H3-DNA and H3 RNA synthesized in vivo by normal and cancerous human tissues]. PMID- 4318902 TI - Isolation and properties of rapidly renaturing fractions of DNA from calf tissues. PMID- 4318903 TI - Energy-dependent control of the latency of mitochondrial enzymes. PMID- 4318904 TI - Purification and properties of a new enzyme from Escherichia coli: nucleoside phosphocyl hydrolase. PMID- 4318905 TI - Preparation of a plasma membrane fraction from rat liver by zonal centrifugation. PMID- 4318906 TI - [Co-existence of various malignant neoplasms in the female genital organs]. PMID- 4318907 TI - Effects of guanosine 3',5'-monophosphate on glycerol production and accumulation of adenosine 3',5'-monophosphate by fat cells. PMID- 4318908 TI - Purification and characteristics of porcine growth hormone. PMID- 4318909 TI - Binding and kinetic studies of liver alcohol dehydrogenase-coenzyme-pyrazole complexes. PMID- 4318910 TI - Effect of bile acid deconjugation on the fecal excretion of steroids. AB - The effect of microbiological deconjugation of bile acids on total bile acid and neutral sterol fecal excretion by adult male rats has been studied. A screening method utilizing mice allowed selection of a Clostridium perfringens type A strain, which accelerated cholesterol catabolism in mice. When this species of bacteria was associated with germfree rats, the fecal bile acids were excreted as free bile acids (deconjugated), however the quantities of bile acids excreted were not increased compared with those of germfree rats. Conventional rats excrete twice as much bile acids (all deconjugated) as do the germfree and C. perfringens-associated rats. It is, therefore, unlikely that the microbiological deconjugation of bile acids is responsible for the increased fecal excretion of bile acids seen in conventional rats. The C. perfringens-associated rats excreted identical kinds and quantities of fecal neutral sterols as did the germfree rats. PMID- 4318911 TI - [Recent advances in the study of the neuromuscular transmission]. PMID- 4318912 TI - [Autopsy case of complication of hepatoma with ileocecal reticulum cell sarcoma]. PMID- 4318913 TI - A longitudinal study of enterovirus infections in Kawasaki, Japan. I. Virus isolations from 1962 to 1966. PMID- 4318914 TI - Clostridium perfringens as the flora in the intestine of healthy persons. PMID- 4318915 TI - The aftercare of schizophrenics: an evaluation of group and individual approaches. PMID- 4318916 TI - [Parkinson's disease and peripheral trauma]. PMID- 4318917 TI - [Its surgery for benign lung tumors justified?]. PMID- 4318918 TI - The effects of 2-acetylaminofluorene and nitrite on free radicals and carcinogenesis in rat liver. PMID- 4318919 TI - Occurrence of desmosterol in tumors of the nervous system induced in the rat by nitrosourea derivatives. PMID- 4318920 TI - Islet cell tumors of the pancreas found in rats given pyrrolizidine alkaloids from Amsinckia intermedia Fisch and Mey and from Heliotropium supinum L. PMID- 4318921 TI - The ratio of albumin synthesis to total protein synthesis in normal rat liver, in host liver, and in Morris hepatoma 9121. PMID- 4318922 TI - Lymphosarcoma: virus-induced thymic-independent disease in mice. PMID- 4318923 TI - Metabolic-independent volume changes and Mg++ binding in mitochondria isolated from AH-130 Yoshida ascites hepatoma. PMID- 4318924 TI - Hexokinase, differentiation and growth rates of transplanted rat tumors. PMID- 4318925 TI - Growth of the spine in congenital vertebral malformations induced in the mouse. PMID- 4318926 TI - Meningitis complicating perforating wounds of the colon and rectum in combat casualties. PMID- 4318927 TI - The uptake of non-metabolizable amino acids as an index of cell viability in vitro. PMID- 4318928 TI - Changes of enzymic activities in human diploid cell line WI-38 at various passages. PMID- 4318929 TI - Initiation of cleavage in frog eggs. An analysis of active large granule fractions from frog liver tissue homogenates. PMID- 4318930 TI - Improved method for preparation of single-cell suspensions from mammary glands of adult virgin mouse. PMID- 4318931 TI - Adrenergic receptors for metabolic responses in the liver. PMID- 4318932 TI - Polyamine synthesis in rapidly growing tissues. PMID- 4318933 TI - Metabolism of polyamines in the nervous system. PMID- 4318934 TI - Adrenal cortical dysfunction in leprosy. PMID- 4318935 TI - Immunologic responses to an adrenocorticotropic hormone preparation in bronchial asthma and rheumatoid arthritis. PMID- 4318936 TI - Carbenicillin therapy of infections due to pseudomonas in children. PMID- 4318937 TI - Rhinovirus infections in chronic bronchitis: isolation of eight possibly new rhinovirus serotypes. PMID- 4318938 TI - The role of surface antigens in the protective potency of Bordetella pertussis suspensions as measured by the intracerebral challenge technique in mice. PMID- 4318939 TI - Studies on the transmission of the agent of infectious hepatitis to patas monkeys. PMID- 4318940 TI - A staphylococcal aggressin. PMID- 4318941 TI - The incidence of cytoplasmic and nuclear inclusions in nonspecific genital infections in men. PMID- 4318942 TI - Simian virus 40 transformation and the period of cellular deoxyribonucleic acid synthesis. AB - The antiviral agents interferon and statolon protected cells of the mouse line 3T3 against the transforming effect of simian virus 40. Loss of ability of these agents to protect when added some time after infection indicated that the transformation was already fixed. The cells of exponentially growing cultures became resistant to the protective effect of interferon at a linear rate after infection; after one cell generation, the whole population was resistant. By use of synchronous cultures, it was shown that, in cells passing though the G-1 period of the growth cycle, the transformation did not pass the interferon sensitive stage, whereas cells in S [the period of cellular deoxyribonucleic acid (DNA) synthesis] readily passed this stage (i.e., became interferon-resistant). An irreversible step in transformation appeared to occur in cells synthesizing DNA, and it seems likely that replicating cellular DNA was the target of the viral action. PMID- 4318943 TI - Effect of the inhibition of protein synthesis on the establishment of transformation by polyoma virus. AB - Puromycin was used to study the effect of the inhibition of protein synthesis on transformation of hamster cells (BHK21) by polyoma virus. The drug was used at a concentration (10(-4)m) which caused in these cells a drastic but fully reversible inhibition of protein synthesis. A two- to threefold enhancement of transformation rate was obtained when the cells were exposed to puromycin for a period of 5 hr that started at the end of the virus adsorption period. No further enhancement was produced by prolonging puromycin treatment up to 13 hr after infection. The possibility that the observed effect on transformation rate could be mainly attributed to cell selection by puromycin was excluded. In addition, the relevance of a number of possible secondary effects of puromycin (inhibition of cell division, inhibition of deoxyribonucleic acid synthesis, etc.) was also ruled out. The effect of puromycin on transformation appeared to be dependent on the time (relative to infection) of addition of the drug. In fact, no transformation enhancement was observed when the cells were exposed to puromycin prior to infection or beyond the 10th hr after infection. Since another drug known to affect protein synthesis (p-fluorophenylalanine) was also shown to produce similar effects, it is suggested that transformation enhancement results from the inhibition of protein synthesis during a sensitive period closely following adsorption of the virus. PMID- 4318944 TI - Morphogenesis of type 2 parainfluenza virus examined by light and electron microscopy. AB - The development of type 2 parainfluenza virus in HeLa and stable human amnion cells was examined by use of antisera labeled with fluorescein and ferritin. Serum containing antibody predominantly to soluble viral antigen gave specific fluorescence which was first detectable in small cytoplasmic foci 8 to 10 hr after initiation of infection. By 20 to 24 hr, when the production of infective virus and hemagglutinin was maximal, large perinuclear aggregates of fluorescence were observed which corresponded in distribution and time of appearance to the eosinophilic inclusions seen in similar preparations stained with azure eosin. The inclusions, examined by electron microscopy, were composed of fibrils, presumably viral ribonucleoprotein, which specifically bound the antibody labeled with ferritin. With antiserum to concentrated virus, on the other hand, specific fluorescence was most marked at the surface of infected cells. Foci of fluorescence at the surface represented segments of membrane which had become differentiated morphologically and antigenically to resemble the viral envelope. These were the sites where mature virions appeared. The latter exhibited marked pleomorphism; in some instances, particles were formed which lacked recognizable internal fibrils but which possessed an enclosing membrane bearing viral antigen. Filamentous forms showing an organized internal structure were also observed at the cell surface, but were never encountered in negatively stained preparations. No clear relationship between these filaments and the spherical or oval forms could be established. In negatively stained preparations, nucleocapsid released by rupture of viral particles was similar in appearance to that reported for other paramyxoviruses. It seems probable that this component has a helical configuration. PMID- 4318946 TI - Comparison of human cytomegalovirus obtained by glycine extraction and by sonic disruption of infected cells. PMID- 4318945 TI - Altered properties of thymidine kinase after infection of mouse fibroblast cells with herpes simplex virus. PMID- 4318947 TI - Distribution of cell receptors and simple sugar inhibitors during encephalomyocarditis virus-cell union. AB - Encephalomyocarditis (EMC) virus was studied for ability to agglutinate erythrocytes of various species. Human, rat, and guinea pig erythrocytes, as well as those from young rabbits, were readily agglutinated. Cells from older rabbits absorbed virus poorly, and showed little agglutination. Uptake of virus by rabbit brain also diminished with age. Various mouse tissues absorbed virus about equally well. Hemagglutination-inhibition studies demonstrated that a number of simple sugars, particularly glucose and galactosamine, interfered with uptake of virus by cells. Dextran sulfates were highly active inhibitors of EMC hemagglutination. Attempts to localize the site of action of the sugars on virus or cell are described. Treatment of virus with periodate or p chloromercurobenzoate, and acetylation of virus, inhibited hemagglutination, but acetylation of semipurified receptor did not. Clarification of the nature of the virus-cell union will require studies to identify possible specific sugars in the virus capsid and the cell receptor. PMID- 4318948 TI - Herpes simplex virus products in productive and abortive infection. I. Stabilization with formaldehyde and preliminary analyses by isopycnic centrifugation in CsCl. AB - Lysates of HEp-2 cells productively infected with herpes simplex virus yielded two bands on isopycnic centrifugation in CsCl gradients, ranging from 1.2 to 1.6 g/cm(3). One band, designated alpha, had a mean buoyant density of 1.27 g/cm(3) and contained herpes virions. Band beta had a mean density of 1.305 g/cm(3) and contained primarily complement-fixing viral antigens and little or no viral deoxyribonucleic acid (DNA). The products banding in the alpha and beta bands were unstable; fivefold or higher amounts were recovered by treating the cell extract with formaldehyde prior to centrifugation. Formaldehyde treatment increased the buoyant density of viral products in both the alpha and beta bands by about 0.015 g/cm(3). In addition, it stabilized hitherto inapparent products, forming a broad band gamma with a density range of 1.37 to 1.45 g/cm(3). The material in the gamma band was heterogeneous; it contained viral DNA, cellular DNA, and viral antigen. Formalinized lysates of DK cells abortively infected with herpes simplex virus yielded a beta band undifferentiated from that formed by extracts of productively infected cells. The gamma band was less dense and narrower. The alpha band was entirely missing. PMID- 4318949 TI - Purification and properties of reovirus ribonucleic acid. AB - NaClO(4) was employed in a technique for the rapid extraction of reovirus ribonucleic acid (RNA). The extracted RNA, which was purified in a Cs(2)SO(4) equilibrium density gradient, had a buoyant density of 1.61 g/cm(3) and a sedimentation coefficient of 15S in a 7 to 20% sucrose gradient. It was 90% resistant to ribonuclease in a solution of high ionic strength (0.1 m NaCl). The sensitivity of reovirus RNA to ribonuclease increased with decreasing ionic strength. The thermal denaturation transition of the RNA began at 78 C and was complete at 85 C. The T(m) of the transition was 81 C in 0.01 m tris(hydroxymethyl)aminomethane buffer (pH 7.2) containing 0.001 m ethylenediaminetetraacetate. Thermal denaturation of reovirus RNA resulted in the formation of three ribonuclease-sensitive fractions. Denaturation at 25 C in the presence of dimethyl sulfoxide resulted in the formation of two ribonuclease sensitive fractions. PMID- 4318950 TI - Separation of plaque-type variants of encephalomyocarditis virus by chromatography on calcium phosphate. AB - Encephalomyocarditis (EMC) virus (K-2 strain) was separated into two distinct peaks of optical density by chromatography on calcium phosphate, eluting at 0.17 and 0.31 m, respectively. The virus in these peaks could not be distinguished by infectivity (plaque-forming units), hemagglutinin activity, electron microscopic appearance, sedimentation coefficient, or base ratios. However, variants producing large plaques predominated in the first peak eluted, whereas variants producing small plaques were concentrated in the second peak. When plaque purified large and small plaque variants were chromatographed individually, each gave a single peak eluting at 0.16 and at 0.43 m, respectively. However, one small plaque type isolated was eluted in the 0.17 m region expected for large plaque variants, and not with the bulk of the small plaque variants. There were indications that EMC virus (K-2 strain) could be separated into more than two peaks by use of selected elution gradients. The possibility that there may be a relationship between plaque size and point of elution from calcium phosphate is discussed. PMID- 4318951 TI - Intrinsic interference: a new type of viral interference. AB - The hemadsorption-negative plaque test has revealed a new type of viral interference, termed intrinsic interference. Several unrelated types of noncytopathic viruses were shown to induce in infected host cells a state of interference unique in being directed solely against superinfection by Newcastle disease virus (NDV). The NDV-refractory state arises only in those individual cells of a population actually infected by the inducing virus, and presumably results from the action of a protein(s) coded for by the viral genome. Thus, intrinsic interference differs fundamentally from that mediated by an extrinsic protein detectable under conditions favoring resistance to a broad spectrum of viruses and characteristic of interference induced by interferon, the latter being coded for by the cell genome. Intrinsic interference is defined as a viral genome-induced cellular state of resistance to challenge by high multiplicities of NDV, coexistent with a state of susceptibility to a broad spectrum of other viruses, similarly tested at high multiplicities. The capacity to induce intrinsic interference was demonstrated with rubella virus, Sindbis virus (arbovirus, group A), West Nile virus (arbovirus, group B), poliovirus (MEF, type 2), the lactic dehydrogenase virus (Riley's agent), and an unidentified nonhemadsorbing, noncytopathic adventitious virus. A state of intrinsic interference was also observed in the V5 line of mouse cells carrying a murine leukemia virus, probably resulting from some heretofore unsuspected contaminating virus. The molecular basis for intrinsic interference is not known, but it appears to involve a step in the NDV growth cycle beyond that of viral attachment, entry, and eclipse. PMID- 4318952 TI - Infective virus substructure from vesicular stomatitis virus. AB - Treatment of suspensions of vesicular stomatitis virus with Tween-ether results in a rapid and considerable loss of infectivity (ca. 4 logs in 2 min), but the residual infectivity is comparatively stable to further treatment with ether. The infectivity remaining after the short exposure to Tween-ether is not due to virus for the following reasons. (i) It is much less infective for tissue cultures than for mice, whereas the intact virion is equally infective for both hosts. (ii) The residual infectivity is much less stable than virus infectivity in both sucrose and tartrate gradients. (iii) Virus immune serum does not neutralize its activity. (iv) The infectivity is associated with material which sediments further in sucrose gradients and has a greater buoyant density in tartrate gradients than the virion. Experiments with (32)P-labeled virion showed that the infective substructure contains ribonucleic acid with the same sedimentation characteristics as that extracted from the virion. Electron microscopy shows that the infective component has the same overall bullet-like structure as the virion but lacks the outer envelope and fringe structure. PMID- 4318953 TI - Electron microscopic study of the development of simian virus 40 by use of ferritin-labeled antibodies. AB - An electron microscopic study of simian virus 40 has revealed a number of structural changes that are related to the development of the virus. The presence of viral antigens in both the nucleus and the cytoplasm has been demonstrated by means of ferritin-labeled antibodies. Although cytoplasmic virions are readily tagged, the lack of tagging of nuclear particles presents a perplexing problem. Presumably, the virus, after release from the nucleus, acquires a new antigenic reactivity in the cytoplasm. PMID- 4318954 TI - Electron microscopy of chick fibroblasts infected by defective rous sarcoma virus and its helper. AB - Nonproducing Rous sarcoma cells of the chicken and their virus-producing as well as uninfected counterparts were studied with an electron microscope. The structural peculiarities of transformed cells included cytoplasmic annulate lamellae, aggregates of membrane-bound, glycogen-like granules, and empty, virus like shells. Of 69 individual lines of nonproducing Rous sarcoma cells, 64 contained small numbers of viral particles. These particles were morphologically indistinguishable from mature avian tumor virus but lacked demonstrable infectivity. In sessile normal and leukosis virus-infected fibroblasts, microtubules and fibrils occurred in parallel arrays at the periphery of the cytoplasm. This cortical organization was absent from rounded Rous sarcoma cells. The characteristics of microtubular arrangement seemed to reflect differences in the locomotory activity of normal and transformed cells. PMID- 4318955 TI - Concentration of enteroviruses on membrane filters. AB - Enteroviruses can be made to adsorb or to pass through membrane filters by manipulation of the suspending medium. Salts facilitate virus adsorption, but membrane-coating components (MCC) interfere. Because cells release MCC into the culture medium during viral growth, MCC must be removed before virus can be adsorbed to membranes. Adsorbed virus can be eluted with diluents containing MCC (cell extracts or serum) or agents that reduce surface tension (sodium lauryl sulfate). By membrane adsorption and elution, enteroviruses can be readily concentrated and quantitatively recovered from crude virus harvests. PMID- 4318957 TI - Effect of magnesium on replication of rhinovirus HGP. AB - It is known that plaque formation by some rhinoviruses is greatly enhanced by increasing the concentration of MgCl(2). The mechanism of this action was studied by investigating the effects of MgCl(2) on rhinovirus HGP adsorption, growth, clumping, thermal stability, and cell susceptibility to viral cytopathic effect. The latent period was at most 7 hr, whether virus was propagated in cells maintained in 0.8 or 30 mm MgCl(2), but virus release was 8- to 310-fold greater in the presence of 30mm MgCl(2), depending on initial multiplicity. Intracellular virus content appeared unaffected by Mg(++) and reached maximal yield (plateau phase) at about 10 hr. Viral adsorption was increased when cells were maintained in 30mm Mg(++). It is likely that the two effects of magnesium, enhanced adsorption and increased virus release, both contribute to enhancement of plaque formation. PMID- 4318958 TI - Interaction of encephalomyocarditis virus with ultraviolet-irradiated host cells. AB - Ultraviolet light (UV) impaired the capacity of L cells to support growth of encephalomyocarditis virus. The loss of capacity was partially restored by high multiplicity of infection (MOI). This phenomenon was not due to an increased probability of an infectious virus particle reaching a site of replication undamaged by UV, since UV-inactivated virus at high MOI induced restoration of the capacity to support multiplication of nonirradiated virus adsorbed at low MOI. Multiplicity reactivation of UV-irradiated virus did not play a role in this phenomenon since restoration of capacity took place without multiplication of the UV-irradiated restoring virus. The evidence indicates that restoration of capacity was not due to viral interactions involving genetic exchange. The ability to restore capacity was a property more radioresistant than infectivity, suggesting that the former is a function only of part of the viral genome. PMID- 4318956 TI - Virus aggregation as the cause of the non-neutralizable persistent fraction. AB - The non-neutralizable or persistent fraction of virus populations has been found to be caused by aggregated virus. Detailed investigation was performed with the prototype strain of echovirus type 4 (Pesascek), as this virus is notorious for its large non-neutralizable fraction. When Pesascek virus was clarified by low speed centrifugation, homologous antiserum hardly neutralized the virus. However, when the virus was filtered through membranes having a porosity only twice the diameter of the virus, monodispersed virus was obtained which was efficiently neutralized. Serum titers were up to 1,000 times higher if the neutralization test was carried out with monodispersed virus. Virus in non-neutralizable aggregates was found to constitute 30% of the infective units of unfiltered Pesascek virus but only 0.1% of the antigenically related DuToit strain. This explains why DuToit strain has been a more satisfactory indicator strain for detecting type 4 antibodies, regardless of the echo 4 strain used for inducing the antibodies. Clarified suspensions and ultrafiltrates of viruses belonging to the picorna-, reo-, myxo-, adeno-, herpes-, and poxvirus groups were studied. Clarified suspensions yielded persistent fractions of 0.005% for poliovirus, of 0.1% for reovirus, of 0.6% for influenza virus, of <0.001% for adenovirus, of 0.06% for herpesvirus, and of 10 to 30% for vaccinia virus. In all cases the persistent fractions were removed by membrane filters which had a pore diameter no larger than twice that of the virus under test, and the high concentration of virus in each ultrafiltrate was completely neutralized by antiserum. PMID- 4318959 TI - Virus-specific ribonucleic acid synthesis in KB cells infected with herpes simplex virus. AB - The production of virus-specific ribonucleic acid (RNA) was investigated in KB cells infected with herpes simplex virus. A fraction of RNA annealable to virus deoxyribonucleic acid (DNA) was found in these cells as early as 3 hr after virus inoculation. Production of this species of RNA increased up to 6 or 7 hr after infection, at which time elaboration of virus messenger RNA (mRNA) declined. At 24 hr after infection, the rate of incorporation of uridine into this RNA was approximately one-half of the rate present at 6 hr after inoculation. Nucleotide analysis of the RNA annealable to virus DNA was compatible with that expected for virus mRNA. Centrifugation showed considerable spread in the size of the virus induced nucleic acid, the bulk of this RNA sedimenting between 12 and 32S. Incorporation of uridine into cell mRNA, ribosomal precursor RNA, and soluble RNA was suppressed rapidly after infection. As is the case with most other cytocidal viruses investigated to date, virus-induced suppression of cell RNA synthesis appears to be a primary mechanism of cell injury. PMID- 4318960 TI - Structure of virus particles extracted from a Burkitt lymphoma cell line. PMID- 4318961 TI - Replication of an adeno-associated virus in canine and human cells with infectious canine hepatitis virus as a "helper". PMID- 4318963 TI - Effect of acute ethanol intake on plasma 11 hydroxycorticosteroid levels. PMID- 4318962 TI - Lipid mobilizing factor from the hypothalamus. PMID- 4318964 TI - Effect of vasopressin on renal cyclic AMP generation in potassium deficiency and patients with sickle hemoglobin. PMID- 4318965 TI - Specific glucocorticoid-binding macromolecules from mouse fibroblasts growing in vitro. A possible steroid receptor for growth inhibition. PMID- 4318966 TI - Involved with hormones. PMID- 4318968 TI - Morphological confirmation of the herpes nature of a carcinogenic virus of primates (Herpes saimiri). PMID- 4318967 TI - Effects of gibberellin and cytokinins on the activity of photosynthetic enzymes and plastid ribosomal RNA synthesis in Phaseolus vulgaris L. PMID- 4318969 TI - Prostaglandin E1 and the release of growth hormone in vitro. PMID- 4318970 TI - Measurement of fast biochemical reactions. AB - In the 4 years since Hammes (87) reviewed, in this journal, the application of flow and relaxation techniques to the study of primary processes in chemical reactions these methods have been applied to a wide range of biochemical problems. These applications have been facilitated by advances in stopped flow and temperature jump instrumentation, especially with respect to the range of physical properties that may be observed during a reaction, and the availability of instruments. PMID- 4318971 TI - Demonstration of biological activity of a murine leukemia virus of New Zealand black mice. AB - Although New Zealand Black mouse embryo and adult tissues show evidence of murine leukemia viral particles and antigens, efforts to demonstrate biological activity of a murine leukemia virus by standard methods have proved negative. Cocultivation of tissues of these mice with non-virus-yielding hamster cells transformed by Moloney sarcoma virus, however, has resulted in the rescue of a pseudotype sarcoma virus, presumably carrying the New Zealand Black mouse leukemia virus coat. This virus has an unusual host restriction, producing foci of cell alteration only in rat cells. PMID- 4318972 TI - Cell communication, calcium ion, and cyclic adenosine monophosphate. AB - The hypothesis advanced in this article requires further validation. Undoubtedly it will require modification as our knowledge of biochemical control increases. Nevertheless, it should prove useful in focusing attention on the apparent similarity in the response of a large number of specific cell types to particular stimuli. Emphasis has been placed on a few common and apparently key elements in these responses. It is recognized that other factors are undoubtedly involved. Specifically, the changes in membrane potentials indicate the likelihood of widespread changes in the properties of the cell membrane, for example, changes in Na(+) and K(+) transport and distribution. These aspects of cellular responses may eventually prove to be of equal or greater importance than those common aspects of the system already identified. PMID- 4318973 TI - Some aspects in the diagnosis and management of external infections of the eye: experiences with a new antibiotic, gentamicin. PMID- 4318974 TI - The role of cytoplasmic membranes in poliovirus biosynthesis. PMID- 4318975 TI - Characterization of poliovirus-specific structures associated with cytoplasmic membranes. PMID- 4318976 TI - [Effects of lowering of oxygen partial pressure on the hair cells of the internal ear]. PMID- 4318977 TI - The role of herpesviruses in adenovirus-associated virus replication in vitro. PMID- 4318978 TI - The reproductive and cell-transforming capacities of avian sarcoma virus B77: inactivation with UV light. PMID- 4318979 TI - The low molecular weight RNAs of Rous sarcoma virus. I. The 4 S RNA. PMID- 4318980 TI - Synthesis of RNA in normal and Rous sarcoma virus-infected cells: effect of bromodeoxyuridine. PMID- 4318981 TI - Studies of the protein subunit of pH-inactivated Mengo virus variants. I. Polypeptide composition. PMID- 4318982 TI - Rapid concentration and purification of polyoma virus and SV40 with polyethylene glycol. PMID- 4318983 TI - Analysis of SV40-induced transformation of hamster kidney tissue in vitro. VII. Induction of SV40 virus from transformed hamster cell clones by various agents. PMID- 4318984 TI - Transformation of hamster cells by variants of PARA-adenovirus 7 Able to induce SV40 tumor antigen in the cytoplasm. PMID- 4318985 TI - Studies on single foci of hematopoietic cells transformed by avian myeloblastosis virus. PMID- 4318986 TI - Mengovirus RNA synthesis in productive and restrictive cell lines. PMID- 4318987 TI - Nonproducer clones of murine sarcoma virus transformed BALB-3T3 cells. PMID- 4318988 TI - [Immuno-cytological observations on the localization of ACTH in the cat pituitary gland]. PMID- 4318989 TI - Adrenocortical and thyroid function in the deprivation syndrome. Comparison with growth failure due to undernutrition, congenital heart disease, or prenatal influences. PMID- 4318990 TI - Chemodectomas of the haeead and neck. PMID- 4318991 TI - Some aspects of regulation of peroxisomes and mitochondria in yeast. PMID- 4318992 TI - Studies on the photoreduction of ferredoxin and the ferredoxin-NADP reductase flavoprotein by chlorplasts fragments: effect of pyrophosphate. PMID- 4318993 TI - Fat metabolism in higher plants. XLI. Properties of potato acetyl coenzyme A synthetase. PMID- 4318994 TI - Methanol activity o alcohol dehydrogenases from human liver, horse liver, and yeast. PMID- 4318996 TI - Parotid tumours: a review of 138 cases. PMID- 4318995 TI - Effect of procyclidine on neuromuscular transmission. PMID- 4318997 TI - Cyclic AMP stimulation of amino acid uptake in bone and kidney. PMID- 4318999 TI - Electron spin resonance and cell division in silkworm egg. PMID- 4319000 TI - Fluorescence in extramammary Paget's disease with superimposed squamous cell carcinoma of the female genitals. PMID- 4318998 TI - Increased synthesis and utilization of serotonin in the central nervous system of the rat during paradoxical sleep deprivation. PMID- 4319001 TI - [Analysis of the variation of heart reactivity to certain physiologically active substances at different stages of the development of a dystrophic process]. PMID- 4319003 TI - Considerations on factors influencing the oxygenation of ascites tumours. PMID- 4319002 TI - A survey of the wheat leaf phosphatases using el filtration with Sephadex G200. PMID- 4319004 TI - Effects of androgen in vivo on some properties of isolated rat ventral prostate nuclei. PMID- 4319005 TI - Metabolism of inositol phosphates. II. Biosynthesis of inositol polyphosphates in germinating seeds of Phaseolus aureus. PMID- 4319006 TI - Studies on nuclear 4.5 S ribonucleic acid III of Novikoff hepatoma ascites cells. PMID- 4319007 TI - The biosynthesis of phosphatidylinositol in human platelets. AB - Homogenates of human platelets can mediate the synthesis of phosphatidylinositol from myoinositol and cytidine diphosphate diglyceride. The cytidine diphosphate diglyceride: myoinositol, phosphatidyl transferase activity is particulate-bound, and the highest specific activity is found in the membrane fraction. The production of phosphatidylinositol is decreased by sulfhydryl-binding agents, and the addition of thiols to the platelet homogenates increases the enzymatic activity. The reaction exhibits a pH optimum of 8.5-9.0. Divalent cations stimulate the reaction, and manganous chloride was the most effective of those investigated. The K(m) of the enzyme for myoinositol is 0.27 mM, and the K(m) for cytidine diphosphate diglyceride is 0.53 mM. The enzymatic activity of platelets isolated from patients with several diseases known to interfere with platelet clotpromoting function is similar to the enzymatic activity of platelets from normal donors. PMID- 4319008 TI - Familial amyloidotic polyneuropathy. Electromyographic study. PMID- 4319009 TI - [Ocular lesions in primary familial amyloidosis (a syndrome associating opacitieis of the vitreous body, vascular lesions of the retina and an amyloid neuropathy)]. PMID- 4319010 TI - The newest development of experimental induced tumors of the central nervous system. PMID- 4319011 TI - Angiotensin II analogs. 3. Synthesis and biological evaluation of some des aspartyl-angiotensins. PMID- 4319012 TI - ATPase in human brain tumors. PMID- 4319013 TI - [Early diagnosis and otological approach in cancer of the auditory nerve]. PMID- 4319014 TI - [Diagnosis of cancer of the auditory nerve and translabyrinthine surgery]. PMID- 4319015 TI - Chemical and electrical synaptic connexions between cutaneous mechanoreceptor neurones in the central nervous system of the leech. AB - Experiments have been made to study the synaptic connexions between sensory cells in the C.N.S. of the leech. Each segmental ganglion contains six neurones that respond specifically to light touch applied to the skin; each of these ;touch cells' innervates a discrete area on the surface of the body and has a characteristic set of properties by which it can be recognized. Using intracellular electrodes it has been shown that these sensory cells interact with one another through chemical and electrical synapses by way of a stereotyped set of pathways.1. Action potentials occurring in one touch cell gave rise to synaptic potentials in the five other touch cells in the same ganglion and also in the three ipsilateral touch cells in the adjacent ganglia. Thus, synaptic interactions took place between sensory cells whose receptive fields lay within the same segment and on the same side of adjacent segments.2. The post-synaptic potentials consisted of a short-latency coupling potential, followed by an excitatory potential and a number of inhibitory potentials. These delayed synaptic potentials occurred inconsistently and with a variable latency; they could also be recorded in the cell which had been stimulated. All of the touch cells appeared to be equally effective in initiating synaptic potentials.3. The short-latency coupling potential was shown to be mediated through an electrical synapse by observing a voltage change in one touch cell when current was injected into its neighbour. It was not abolished by high concentrations of Mg in the bathing fluid, which blocked chemical synapses in this ganglion. This electrical synapse displayed remarkable rectification; a depolarization could spread from cell to cell in both directions, while a hyperpolarization could spread in neither.4. The inhibitory potentials were reversed by injecting Cl into the cell. In Cl-free Ringer solution this effect was so marked that the reversed IPSPs caused long trains of impulses in touch cells, which tended to excite each other by a process of positive feed-back.5. Synaptic potentials evoked by activation of a touch cell did not usually reach threshold since excitation and inhibition tended to cancel. The connexions between touch cells that mediated the delayed excitatory and inhibitory potentials are polysynaptic; the interneurones have not yet been found but some of their connexions could be inferred from electrical recordings.6. Action potentials in sensory cells of a different modality (responding to pressure) also initiated synaptic potentials in the same family of touch cells.7. The possible significance for integration of these synaptic interactions between sensory cells is discussed. PMID- 4319017 TI - [Theory of the 2nd messenger for the hormonal action: the cyclic adenosine phosphate]. PMID- 4319016 TI - Histochemical and ultrastructural changes observed in the mucosa of the ileal conduit. PMID- 4319018 TI - Electron paramagnetic resonance study of wool irradiated by ultraviolet and visible light. PMID- 4319019 TI - [Adrenocorticotropic potency of [Glyl]-ACTH(1-18)-octadecapeptide amide (50022S) in man]. PMID- 4319020 TI - Experimental peripheral neuropathy. PMID- 4319021 TI - [Osseous metastasis in chronic myeloid leukemia]. PMID- 4319022 TI - [Indications for splenectomy in cirrhosis]. PMID- 4319023 TI - [Elective resection of the 4th lumbar sympathetic ganglion in the surgical treatment of arteriopathy of the lower limbs]. PMID- 4319024 TI - [Meningococcia with necrotic purpura and paralysis of the lower limbs in a 17 month-old infant. Favorable evolution]. PMID- 4319025 TI - [Does syphilis still erode the spine?]. PMID- 4319026 TI - [Development in the relationship of endometriosis and pregnancy under the influence of present treatments]. PMID- 4319027 TI - [Clinical and experimental value of measurements of PO2 and PCO2 in the non circulating extracellular compartment]. PMID- 4319029 TI - [Atmospheric pollution and its role in respiratory pathology]. PMID- 4319028 TI - [Problems raised by sexual ambiguities at birth]. PMID- 4319030 TI - [Clinical and therapeutic aspects of hepatic distomatosis]. PMID- 4319031 TI - [Treatment of infantile spasms with hypsarrhythmia]. PMID- 4319032 TI - [Neurogenic mechanisms in the pathogenesis of renal hypertension]. PMID- 4319033 TI - [Memory at the level of the individual neuron]. PMID- 4319034 TI - The silent patient in group therapy. PMID- 4319035 TI - Instituting change in psychiatric geriatric settings. PMID- 4319036 TI - The effect of medical education upon the image of and orientation toward the medical profession. PMID- 4319038 TI - The biochemistry of mental disorders. PMID- 4319037 TI - Nursing assistants benefit by seminar approach inservice. PMID- 4319039 TI - Psychiatric drugs and trends. Review of the phenothiazines. II. PMID- 4319040 TI - Personality, morale and rapid turnover among nurses. PMID- 4319041 TI - [Far infrared and proton magnetic resonance spectra of chloramphenicol palmitate]. PMID- 4319042 TI - The histiocyte in radiology; with case reports of retroperitoneal xanthogranuloma and malignant fibrous xanthoma. PMID- 4319043 TI - Effects of N1-alkylnicotinamide chlorides on NADH oxidation in rat liver submitochondrial particles. PMID- 4319044 TI - Transfer RNA methylase activities of SV40-transformed cells and cells infected with animal viruses. PMID- 4319046 TI - On the heat resistant strains of Clostridium perfringens isolated in Hong Kong. PMID- 4319045 TI - Carbenicillin in treatment of severe infections due to pseudomonas. PMID- 4319047 TI - [The ACTH-oxytocin association in the treatment of edematigenous cerebral diseases]. PMID- 4319048 TI - Experimental carcinogenesis in the nervous system with N-nitroso-compounds. PMID- 4319050 TI - [Clear-cell sarcoma of sheaths and tendons. Apropos of a case]. PMID- 4319049 TI - Clinical and cytogenetic studies in hypospadias. PMID- 4319051 TI - Marek's disease: transmission of infection by filtrate of feather follicles. PMID- 4319052 TI - Changes in stage 1-REM and stage 4 sleep during naps. PMID- 4319053 TI - [On the cytological aspects of 3 in-vitro stabilized cell lines from fibroma induced in hamsters with polyoma virus]. PMID- 4319054 TI - Prolonged tonic convulsions in REM deprived mice. PMID- 4319055 TI - Skeletal maturation of Indian children. PMID- 4319056 TI - Mandibulo-facial dysostosis with syndactyly. PMID- 4319058 TI - Carcinoma of the colon in children. PMID- 4319057 TI - Atypical deep peroneal neuropathy in presence of accessory deep peroneal nerve. AB - The clinical and electrophysiological findings in two patients with a deep peroneal neuropathy occurring in the presence of significant innervation of the extensor digitorum brevis muscle by the accessory deep peroneal nerve are reported. This nerve is a branch of the superficial peroneal nerve which was not involved in either cases reported. An awareness of this anatomical variation of innervation of the extensor digitorum brevis muscle is important for the correct clinical and electromyographic evaluations of deep peroneal nerve lesions. The electromyographic findings in this situation are sufficiently characteristic to identify clearly this anatomical variant. From a clinical point of view, residual function in the lateral portion of the extensor digitorum brevis muscle, in the face of an otherwise complete deep peroneal palsy, should suggest this anatomical variation. PMID- 4319059 TI - Wilm's tumor with aniridia. PMID- 4319060 TI - [Transplantable osteosarcoma caused by the "Moloney strain of murine sarcoma virus (M-MSV)" in Osborne-Mendel rats]. PMID- 4319061 TI - Five years' experience with solid tumors at Children's Hospital, Washington, D.C. PMID- 4319062 TI - Herpesvirus infections. PMID- 4319063 TI - [Use of green coconut milk for the culture of animal cells]. PMID- 4319064 TI - [Clinical contribution to the course of neurobrucellosis]. PMID- 4319065 TI - [Hemorrhagic necrosis of the adrenal glands]. PMID- 4319067 TI - [47,XXY Klinefelter's syndrome and familial marker chromosomes (double satellite on a chromosome of group D)]. PMID- 4319066 TI - [Leukemic meningitis. Statistics of 33 cases]. PMID- 4319068 TI - [Peritoneal dialysis and antibiotic therapy. Personal data about gentamicin and general posologic tables]. PMID- 4319069 TI - [Digestive spasmophilia, erythrocyte magnesium and Vichy cure]. PMID- 4319070 TI - Role of pituitary ACTH in the regulation of radiocalcium and radiophosphorus utilization in the Indian catfish, Heteropneustes fossilis Bloch. PMID- 4319071 TI - Professor Hippolyte Aye. President of the Twenty-third World Health Assembly. PMID- 4319072 TI - [Experimental pulmonary embolism with iodine-containing contrast media in the rat. An electron microscope study]. PMID- 4319074 TI - [Rapid enzymatic detection of ethanol in capillary blood]. PMID- 4319073 TI - Contribution to the evolution of blood pressure regulation. II. Evidence for the absence of kinin-like polypeptides released by proteolytic enzymes for blood pressure regulation in fish. PMID- 4319075 TI - [Adrenal virilism caused by an ovarian tumor]. PMID- 4319076 TI - The nervous system diseases associated with varicella. A critical commentary with additional notes on the syndrome of acute encephalopathy with fatty hepatosis. PMID- 4319077 TI - Immunologic abnormalities induced by postperfusion cytomegalovirus infection. PMID- 4319078 TI - Supervision of outpatient drug therapy with the medication monitor. PMID- 4319079 TI - Measurement of subcutaneous fat cells from obese patients. PMID- 4319080 TI - Remission of Cushing's syndrome after unilateral adrenal phlebography. Apparent destruction of adrenal adenoma. PMID- 4319081 TI - Serotonin now: clinical implications of inhibiting its synthesis with para chlorophenylalanine. PMID- 4319082 TI - Studies on purified citrate-enzymes: metabolic interpretations. PMID- 4319083 TI - Penetration of the mitochondrial membrane by tricarboxylic acid anions. PMID- 4319084 TI - Control of citrate synthesis in mitochondria. PMID- 4319085 TI - Arbovirus vaccines. PMID- 4319087 TI - Some recent trends in vaccination against respiratory viruses. PMID- 4319086 TI - Immunization against poliomyelitis. PMID- 4319088 TI - Status of cytochrome C and cytochrome C oxidase in iron deficiency anaemia. PMID- 4319089 TI - Influence of blood clearance rates on interferon production and virulence of Mengo virus plaque mutants in mice. PMID- 4319090 TI - The arginine requirement for nucleocapsid maturation in Herpes simplex virus development. PMID- 4319091 TI - Alveolar cell carcinoma of the lung. PMID- 4319092 TI - Role of the kidney in experimental renovascular hypertension. PMID- 4319093 TI - Neurogenic hypertension, with special reference to the central neurogenic effects of angiotensin. PMID- 4319094 TI - Metabolism and blood levels of angiotensin II in normal subjects, renal disease, and essential hypertension. PMID- 4319095 TI - Biological significance of renin angiotensin immunization. PMID- 4319096 TI - The role of angiotensin. Indirect studies with antiangiotensin plasma. PMID- 4319097 TI - A microperfusion study of some factors controlling sodium absorption and glomerular filtration in the nephron of the rat. PMID- 4319098 TI - [The biosynthesis of D-aldgarose]. PMID- 4319099 TI - The functional properties of the Zn2(plus)-and Co2(plus)-alkaline phosphatases of Escherichia coli. Labelling of the active site with pyrophosphate, complex formation with arsenate, and reinvestigation of the role of the zinc atoms. PMID- 4319100 TI - Chemically modified phenylalanine transfer ribonucleic acid from yeast. Synthesis and properties of tRNA Phe-C-Cs-A and the effect of adenosine 5'-O-(1 thiotriphosphate) on the activation of phenylalanine. PMID- 4319101 TI - The J blood-group substance of cattle. J haptenic activity of glycosphingolipids of serum. PMID- 4319102 TI - Opportunistic infections in neoplastic diseases. PMID- 4319103 TI - Observations on the behaviour of Entamoeba histolytica in culture. PMID- 4319104 TI - Hepatoblastoma. (A case report). PMID- 4319105 TI - Studies on insulin secretion in man with emphasis on prediabetes. PMID- 4319106 TI - Lactate dehydrogenase. XI. Effects of guanidination upon the properties of the enzyme. PMID- 4319107 TI - Regulation of microsomal enzymes by phospholipids. I. The effect of phospholipases and phospholipids on glucose 6-phosphatase. PMID- 4319108 TI - Phosphate binding to alkaline phosphatase. Metal ion dependence. PMID- 4319109 TI - Mung bean nuclease I. 3. Purification procedure and (3') omega monophosphatase activity. PMID- 4319110 TI - A comparative study of glycopeptides derived from selected vertebrate collagens. A possible role of the carbohydrate in fibril formation. PMID- 4319111 TI - Regeneration of activity by mixture of ribonuclease enzymically degraded from the COOH terminus and a synthetic COOH-terminal tetradecapeptide. PMID- 4319113 TI - Radionuclide angiogram and scan findings in a case of herpes simplex encephalitis. PMID- 4319112 TI - Glomangiomatosis. Anatomo-clinical study of a case. PMID- 4319114 TI - Mesenchymal renal neoplasms of infancy. PMID- 4319115 TI - Aliphatic hydroxylamines as lipid antioxidants. PMID- 4319116 TI - Accumulation of acidic phospholipids in a case of hyperlipidemia with hepatosplenomegaly. PMID- 4319117 TI - Differences in composition and function of iodinated substances in stimulated thyroid glands. PMID- 4319118 TI - Urinary excretion of 3',5'-AMP in syndromes considered refractory to parathyroid hormone. PMID- 4319119 TI - Stu8es on an ACTH-activated adenyl cyclase from a mouse adrenal tumor. PMID- 4319120 TI - Cushing's syndrome caused by ACTH- and calcitonin-secreting medullary carcinoma of the thyroid. PMID- 4319121 TI - Antilipolytic effects of growth hormone. PMID- 4319122 TI - Relation of fat cell ATP content to lipolysis induced by dibutyryl 3',5', cyclic AMP. PMID- 4319123 TI - [Fluorimetry of Schiff-positive mucopolysaccharides in the blood and mucosal tissue of the esophagus, stomach and duodenum]. PMID- 4319124 TI - [Hereditary compression neuropathy. A classification problem in hereditary neurologic diseases]. PMID- 4319125 TI - Quantitative aspects of immunization against primary SV40-induced tumours. PMID- 4319126 TI - Malignant mixed mullerian tumor of the fallopian tube. Report of a case. PMID- 4319127 TI - Maternal urinary estriol excretion after administration of ACTH to the fetus. PMID- 4319128 TI - Herpetic inclusions in the endometrium. PMID- 4319129 TI - Cylindroma of the maxillary antrum. A case presentation and review of the literature. PMID- 4319130 TI - Viral hepatitis. PMID- 4319131 TI - Hepatitis. PMID- 4319132 TI - Capreomycin and other drugs in the treatment of pulmonary tuberculosis. PMID- 4319133 TI - Ethambutol in the treatment of 26 patients with chronic active pulmonary tuberculosis. PMID- 4319134 TI - Treatment of patients with drug-resistance in economically developed countries. PMID- 4319135 TI - Lipid analysis in the classification of mycobacteria. PMID- 4319136 TI - The treatment of infection due to "atypical" mycobacteria. PMID- 4319137 TI - Wilm's tumor and congenital malformations. PMID- 4319138 TI - Herpes genitalis in Ibadan. PMID- 4319139 TI - Primary hepatoma. PMID- 4319140 TI - Virulence of Entamoeba histolytica according to the strains in Korea. I. Comparison of indirect fluorescent antibody test and immobilization test for the sero-diagnosis of amoebiasis. PMID- 4319142 TI - Cytological aspects of haemoglobin and chlorocruorin synthesis in polychaete Annelids. PMID- 4319141 TI - Virulence of Entamoeba histolytica according to the strains in Korea. II. Studies on the pathogenicity of Entamoeba histolytica strains in rats. PMID- 4319143 TI - On the fine structure of peculiar inclusion bodies in vascular adventitial cells. PMID- 4319144 TI - [Possibility of identifying burned human bones with special reference to their weight]. PMID- 4319145 TI - [A method for the determination of biological bone age]. PMID- 4319146 TI - Comparison of protein precipitants used prior to determination of citrate in biological materials. PMID- 4319147 TI - Quartz-halogen lamps: high-intensity visible light sources for laboratory spectrophotometers. PMID- 4319148 TI - New radiochemical method for assay of enzymes catalyzing the cleavage of inorganic pyrophosphate. PMID- 4319149 TI - Synthesis of 5'-amido analogs of adenosine (3'-5')-cyclophosphates. PMID- 4319150 TI - Dietary regulation of glycolytic enzymes. V. Lack of effect of intramuscularly administered sex steroid on male and female rat jejunum. PMID- 4319151 TI - Dietary regulation of glycolytic enzymes. VI. Effect of dietary sugars and oral folic acid on human jejunal pyruvate kinase, phosphofructokinase and fructosediphosphatase activities. PMID- 4319152 TI - Dietary regulation of glycolytic enzymes. 8. Dose and time response of rat jejunal enzymes to oral sex hormones. PMID- 4319153 TI - Enzymatic synthesis of glycerol I-phosphate. Elevation in diabetic and fasted animals, compared with glucose-6-phosphatase and related enzyme activities. PMID- 4319154 TI - Differential effects of Ca2+, EDTA and adrenergic blocking agents on the actions of some hormones on adenosine 3',5'-monophosphate levels in isolated adipose cells as determined by prior labeling with [8-14C] adenine. PMID- 4319155 TI - Magnetic properties of some flavin metal complexes. PMID- 4319156 TI - Submaxillary gland tumors. PMID- 4319157 TI - Carcinoma of the breast in women less than thirty years old. PMID- 4319158 TI - Endobronchial Polymyxin B: experimental observations in chronic bronchitis. PMID- 4319159 TI - Antibodies against Adenoviruses in the sera of healthy individuals. PMID- 4319160 TI - Skeletal growth in school children. PMID- 4319161 TI - The use and limitations of electroneuromyography. PMID- 4319162 TI - Macroglobulinemia complicated by pneumocystis pneumonia and cytomegalic inclusion disease including postmortem examination of the eyes. PMID- 4319163 TI - [Surgery of breast neoplasms]. PMID- 4319164 TI - [Less poxvirus infections]. PMID- 4319165 TI - [Long-term results of rehabilitation therapy in cases of advanced radicular sciatica]. PMID- 4319166 TI - The problem of volition. PMID- 4319167 TI - Habituation: a dual-process theory. PMID- 4319168 TI - Sleep cycles and skin potential in newborns studies with a simplified observation and recording system. PMID- 4319169 TI - [Further observations on blood cortisol behavior in children with convulsive encephalopathy before, during and after treatment with corticotropin]. PMID- 4319170 TI - [Histoenzymologic research on mixed salivary gland tumors]. PMID- 4319172 TI - [Functioning of the genome of tumor-generating viruses in infected and transformed cells]. PMID- 4319171 TI - [Influence of thymectomy, splenectomy and cortisone on cancerogenesis]. PMID- 4319173 TI - [Experience in the management of childhood kidney tumors]. PMID- 4319174 TI - [The scintillation camera in the diagnosis of cerebral neoplasms]. PMID- 4319175 TI - Scintigraphic and angiographic exploration of the pancreas in a case of insulinoma: presentation of a new scintigraphic technique. PMID- 4319176 TI - Postinfarction myocardial hypersensitivity to naturally occurring humoral agents in dogs. PMID- 4319177 TI - Hypoglycemia due to islet cell tumor of the pancreas. PMID- 4319178 TI - A gas-chromatographic method for the determination of vitamin D in fortified non fat dried milk. PMID- 4319180 TI - A possible mechanism for hypertension induced by oral contraceptives. Diminished feedback suppression of renin release. PMID- 4319179 TI - Cytomegalovirus infection in the north west of England. A report on a two-year study. PMID- 4319182 TI - Lymphangiography. II. PMID- 4319181 TI - Streptozotocin therapy for metastatic insulinoma. PMID- 4319183 TI - The clinical and laboratory diagnosis of variola minor (alastrim). PMID- 4319184 TI - Acquired lesions of the fourth cranial nerve. PMID- 4319185 TI - The effects of experimental demyelination on conduction in the central nervous system. PMID- 4319186 TI - The incidence of the non-metastatic neurological syndromes of obscure origin in the reticuloses. PMID- 4319187 TI - Electron microscopic localization of acid phosphatase and thiamine pyrophosphatase activities in the motoneurons of exercised mice. PMID- 4319190 TI - Primary carcinoma of the liver in Bombay. PMID- 4319188 TI - Histochemistry of Langerhans' islets in the pancreas of cattle (Bos Taurus L.). PMID- 4319191 TI - Oxygen uptake of virus-induced fused cells. PMID- 4319189 TI - Effect of hypoxia on phosphoesterases, oxidative and glycolytic enzymes in the rabbit common carotid artery. A histochemical study. PMID- 4319193 TI - Streptozotocin for metastatic insulinoma. PMID- 4319192 TI - Vitamin D3 action on D,L-serine-3-14C incorporation into phospholipid fractions with rat liver mitochondria. PMID- 4319194 TI - Plasmatic and erythrocytic angiotensinase activity in subjects with arterial hypertension. PMID- 4319195 TI - [Hormonal and metabolic correlations between adrenocortical hormones and cyclic adenylic nucleotide]. PMID- 4319197 TI - [Nutritive vascularization of bronchial neoplasms in the arteriographic picture]. PMID- 4319196 TI - [Aetiology and pathogenesis of chronic arterial hypertension]. PMID- 4319198 TI - Spontaneous in vitro neoplastic transformation of adult human prostatic epithelium. AB - The possible significance of spontaneous transformation of epithelium from a benign prostatic adenoma containing glandular hyperplasia is discussed. PMID- 4319199 TI - Transfer of bilirubin uridine diphosphate-glucuronyltransferase to enzyme deficient rats. AB - Cells from a clonal strain (MH(1)C(1)) of rat hepatoma were transplanted subcutaneously into two homozygous Gunn rats, which are jaundiced because the enzyme bilirubin uridine diphosphate-glucuronyltransferase is absent from the liver. Because of the enzyme activity present in the transplanted cells, the recipient rats developed the capacity to conjugate bilirubin and reverted in large part to a normal pattern of bilirubin excretion. PMID- 4319200 TI - Intestinal mucosal hyperplasia following induced hyperthyroidism in the rat. PMID- 4319201 TI - Further research on Azotobacter paspali and its variety specific occurrence in the rhizosphere of Paspalum notatum Flugge. PMID- 4319202 TI - [Microbiological properties of a gneiss brown soil under deciduous and coniferous forest cover]. PMID- 4319203 TI - Primary linitis plastica of the colon and rectum. PMID- 4319204 TI - [Electron spin resonance (ESR) and infrared spectra of eye melanin and of the pigment in substantia nigra]. PMID- 4319205 TI - [Studies of the relationship between the degree of acetylcholinesterase inhibition by organophosphates and the decrease in tetanic responses in a phrenic nerve-diaphragm preparation of the rat]. PMID- 4319206 TI - Laboratory determinations of aldosterone and their clinical significance. PMID- 4319207 TI - Clinical manifestations of primary aldosteronism. PMID- 4319208 TI - Secondary aldosteronism: with observations on the definition of hypokalemia. PMID- 4319209 TI - Renin and angiotensin in relation to aldosterone. PMID- 4319210 TI - Structural and growth patterns of adenoid cystic carcinoma of breast. PMID- 4319211 TI - Pseudomembraneous enterocolitis--an unwelcome gastrointestinal complication of antibiotic therapy. PMID- 4319212 TI - Jacobson's neurectomy for Frey's syndrome. PMID- 4319213 TI - Measurement of intrahepatic shunted blood flow by means of D-galactose-1-C14 in experimental hepatic injuries. PMID- 4319214 TI - Relation of zinc metalloenzyme activities to zinc concentrations in tissues. PMID- 4319215 TI - The redox state of NADplus-NADH systems in guinea pig liver during increased fatty acid oxidation. PMID- 4319216 TI - Glyoxylate metabolism by isolated rat liver peroxisomes. PMID- 4319217 TI - Interactions of phospholipids with thyroglobulin and their influence on the enzymic hydrolysis of this protein. PMID- 4319218 TI - Regulation of purine biosynthesis in cultured human cells. I. Effects of orotic acid. PMID- 4319219 TI - Isolation and characterization of keratan sulfates from the liver of a patient with GM1-gangliosidosis type I. PMID- 4319220 TI - Study of the effect of exogenous glucose on the excess formation of porphyrins and NADH in the liver of rats intoxicated with ethanol. PMID- 4319221 TI - Human erythrocyte "ITPase": an ITP pyrophosphohydrolase. PMID- 4319222 TI - [A case of bilateral kerato-conjunctivitis due to a herpetic primo-infection in an adult]. PMID- 4319223 TI - The vogue in renal physiology: a review article. PMID- 4319224 TI - The clinical features of E. histolytica infection in Europeans and Africans in Rhodesia. PMID- 4319225 TI - Drug therapy in alcoholism. PMID- 4319226 TI - Clinical, virological & serological studies on monkey after intravenous inoculation of virulent variola virus. PMID- 4319227 TI - Biochemical maturation of rabbit fallopian tube. PMID- 4319228 TI - EB viral antigens in Burkitt tumor biopsies and early cultures. PMID- 4319229 TI - Studies on the mechanisms of invasion in cancer. I. Isolation and purification of a factor chemotactic for cancer cells. PMID- 4319230 TI - Inheritance of susceptibility to Friend mouse leukemia virus. VII. Establishment of a resistant strain. PMID- 4319231 TI - Burkitt's lymphoma and malaria. PMID- 4319232 TI - Demonstration of two group-specific TSTAs in adenovirus-induced tumors. PMID- 4319233 TI - Isolation of murine sarcoma virus-transformed mouse cells which are negative for leukemia virus from agar suspension cultures. PMID- 4319234 TI - Partial resolution of the enzymes catalyzing oxidative phosphorylation. 23. Preservation of energy coupling in submitochondrial particles lacking cytochrome oxidase. PMID- 4319235 TI - Ribonucleotide reductase and cell proliferation. I. Variations of ribonucleotide reductase activity with tumor growth rate in a series of rat hepatomas. PMID- 4319236 TI - On the role of K+ on oxidative phosphorylation. PMID- 4319237 TI - Phosphoenolpyruvate synthetase of Escherichia coli. Purification, some properties, and the role of divalent metal ions. PMID- 4319238 TI - Phosphoenolpyruvate synthetase. Partial reactions studied with adenosine triphosphate analogues and the inorganic phosphate-H2 18O exchange reaction. PMID- 4319239 TI - An exonuclease specific for double stranded deoxyribonucleic acid. PMID- 4319240 TI - Deoxyribonucleotide pools and deoxyribonucleic acid synthesis in cultured mouse embryo cells. PMID- 4319241 TI - Regulation of biodegradative threonine deaminase synthesis in Escherichia coli by cyclic adenosine 3',5'-monophosphate. PMID- 4319243 TI - Diphosphopyridine nucleotide-linked isocitrate dehydrogenase from bovine heart. Polymeric forms and subunits. PMID- 4319245 TI - Hypophosphatasia in an adult. PMID- 4319244 TI - Glycylhydroxyprolyl sequences in earthworm cuticle collagen: glycylhydroxyprolylserine. PMID- 4319242 TI - Substrate-induced changes in visible absorption and electron spin resonance properties of adrenal cortex mitochondrial P450. PMID- 4319246 TI - Influence of X irradiation and the milk agent on growth of transplanted mouse mammary tumors. PMID- 4319248 TI - Factors influencing canine mammary cancer development and postsurgical survival. PMID- 4319247 TI - Survey of cancer in children admitted to a Brazilian charity hospital. PMID- 4319249 TI - Titrations of mammary tumor virus in fresh and treated R3 milk and milk fractions. PMID- 4319250 TI - Development of an infectivity assay for mouse mammary-tumor virus. PMID- 4319251 TI - DNA replication and degradation in mammalian tissues. V. A series of slow-growing rat renal tumors and a variety of human cancers. PMID- 4319252 TI - Development of tumors, particularly mammary tumors, in agent-free substrain R3eB De mice. PMID- 4319253 TI - [Anaphylactic shock with fatal outcome after injection of synthetic corticotropin (Synacthen Depot) in a patient with severe asthma]. PMID- 4319254 TI - Practical management of parotid salivary gland tumors. PMID- 4319256 TI - [Estimation of malignant salivary gland neoplasms by the means of punction cytology]. PMID- 4319255 TI - [Hormones and stress]. PMID- 4319257 TI - [Pathologic anatomy of "mixed" tumors of the lacrimal glands]. PMID- 4319259 TI - Immunofluorescent studies on the reactivity of "early" and "late" herpes-immune rabbit sera with virus-induced antigenic formations of HEp-2 cells. PMID- 4319258 TI - Succinylcholine--prolonged apnoea and some dangers. PMID- 4319261 TI - Growth of the equine infectious anemia virus in a continuous-passage horse leukocyte culture. PMID- 4319260 TI - The effect of temperature on the development of immunofluorescent elements in herpes simplex virus infected BS-C-1 cells. PMID- 4319262 TI - Bluetongue in cattle: efficacy of the agar gel precipitin test. PMID- 4319263 TI - A mutant of hog cholera virus inducing interference in swine testicle cell cultures. PMID- 4319264 TI - Choice of solvent for analysis of conjugated and unconjugated Porter-Silber chromogens in urine of beagle dogs. PMID- 4319266 TI - Metabolic control in flow systems. I. Sustained glycolytic oscillations in yeast suspension under continual substrate infusion. PMID- 4319265 TI - [Cylindroma. Apropos of a case of cylindroma of the sublingual salivary gland]. PMID- 4319267 TI - [Metabolic control in flow systems. II. Regulation of ethanol synthesis and pool turnover in yeast under continuous substrate infusion]. PMID- 4319268 TI - Isolation and study of the enzymes involved in the metabolism of hydrocarbons by Candida tropicalis. PMID- 4319269 TI - [Right parieto-temporo-occipital carrefour syndrome. Serial study of a case operated on for glioblastoma of the region]. PMID- 4319270 TI - Studies of herpes zoster virus in vitro. II. An autoradiographic study of intranuclear inclusions. PMID- 4319271 TI - [Photochemical transformations of paramagnetic centers in a gamma-irradiated monocrystal of L-cystine dihydrochloride]. PMID- 4319272 TI - [EPR study of the nitrogen-fixing system of Azotobacter vinelandii]. PMID- 4319274 TI - [Endogenous rhythms with annual periodicity]. PMID- 4319273 TI - [EPR of metabolizing mitochondria during the operation of point 3 of phosphorylation]. PMID- 4319275 TI - [Saturation of S-potentials of fish retina. The L-type reaction]. PMID- 4319276 TI - [New specific paramagnetic label based on trichlortriazine]. PMID- 4319278 TI - [EPR spectra of frozen animal tissues]. PMID- 4319277 TI - [EPR spectra and the structure of free radicals in irradiated monocrystals of L leucine hydrochloride]. PMID- 4319279 TI - [Polymerase metabolism in poliovirus in mixed cellular infections]. PMID- 4319280 TI - [Influence of silicotigenic dusts on the onset of pulmonary tumors induced by 3,4 benzopyrene in rats]. PMID- 4319281 TI - Chemotherapy of tuberculosis. PMID- 4319283 TI - [Formation and transformation of radicals in meso-inositol under the effect of gamma-radiation]. PMID- 4319282 TI - [Free radicals and energy exchange in leukocytes in leukoses]. PMID- 4319284 TI - [Nature of rapid potential fluctuations in intrazonal responses of the somatosensory cortex]. PMID- 4319285 TI - [Localization and state of polyphosphates and polyphosphatases in fungal cells]. PMID- 4319286 TI - [Properties of corticospinal and afferent synaptic effects on lumbar motor neurons of the monkey]. PMID- 4319287 TI - A study of the pressor activity in the blood of rats with experimentally induced hypertension. PMID- 4319288 TI - Changes in level of bradykininogen and pressor activity in blood of rats with experimental hypertension. PMID- 4319289 TI - Electron-papamagnetic resonance study of the histamine-binding effect of ceruloplasmin. PMID- 4319290 TI - [Optic non-homogeneity of the cell nucleus in the process of nerve tissue differentiation]. PMID- 4319291 TI - A method of assay of renin activity in plasma and kidneys and of angiotensinase activity in plasma of rats. PMID- 4319292 TI - The influence of ACTH on the pool of the free nucleotides in adrenals and livers of rats. PMID- 4319293 TI - [Separation and microbiological determination of polymyxin, neomycin and a nitrofuran chemotherapeutic agent]. PMID- 4319294 TI - [Action mechanism of thyroid stimulating hormones (TSH and LATS)]. PMID- 4319295 TI - [Hormonal regulation on the membrane permeability of sugar]. PMID- 4319297 TI - Fungal infection and extramammary paget's disease of the skin. A deceptive double diagnosis. PMID- 4319296 TI - [Action mechanism of LH--in vivo study on the theory of c-AMP participation]. PMID- 4319298 TI - [So-called cystosarcoma phyllodes of the breast]. PMID- 4319299 TI - [Changes in some enzyme activities of the arterial wall in post-hypophyseal hormone experimental arteriopathies]. PMID- 4319300 TI - Effects of ganglionic and cholinergic blocking drugs on the pressor response to central vagal stimulation. PMID- 4319301 TI - [Neurosurgical contributions to rehabilitation]. PMID- 4319302 TI - Research on neurotransmitter-like substance from insects. PMID- 4319303 TI - [1st report of adenovirus infections in Turkish army recruits]. PMID- 4319304 TI - [Use of Videin--vitamin D3--in pediatric dermatovenereological practice]. PMID- 4319306 TI - Antiviral activity and molecular features of benzimidazoles. PMID- 4319305 TI - Blood flow in transplanted tumors: quantitative approaches to radioisotopic studies. PMID- 4319307 TI - Antiviral activity of calcium elenolate on parainfluenza infection of hamsters. PMID- 4319308 TI - Interferon induction by and ribonuclease sensitivity of thiophosphate-substituted polyribonucleotides. PMID- 4319309 TI - Effect of Mycoplasma pneumoniae on rhinovirus ribonucleic acid synthesis in KB cells. PMID- 4319310 TI - Treatment of congenital cytomegalic inclusion disease with antiviral agents. PMID- 4319311 TI - Antibiotics, as elucidators of nucleic acid structure, replication, and transfer. PMID- 4319312 TI - Evidence for the participation of a cholinergic receptor in adrenergic transmission. PMID- 4319313 TI - [Adrenal response to corticotropin in normal subjects]. PMID- 4319314 TI - [Interaction of nitrous bases of nucleic acids with electron acceptors]. PMID- 4319315 TI - [EPR study of the interaction between the nitrogen-fixing complex of Azotobacter vinelandii and inhibitors of N2 fixation]. PMID- 4319316 TI - [Nature and transformations of paramagnetic centers in gamma-irradiated solutions of pyrimidine bases and DNA]. PMID- 4319317 TI - [Phototransformations of porphyrins in frozen solutions. Reduction of acid cation forms of etioporphyrin]. PMID- 4319318 TI - [Interrelation between electron transport and the transport ATPase system of microsomes]. PMID- 4319320 TI - [Saturation of S-potentials of fish retina. Bicomponent reactions]. PMID- 4319319 TI - [EPR spectra of iron-containing complexes arising in animal tissues during some types of hypoxia]. PMID- 4319322 TI - [EPR spectra of lyophilized and frozen animal and plant tissues]. PMID- 4319321 TI - [EPR study of propyl gallate radical reactions in irradiated frozen solutions of DNA in the presence of oxygen]. PMID- 4319324 TI - [Nature of the EPR spectrum of concentrated diphtheria toxins and antitoxins]. PMID- 4319323 TI - [Change of the form of EPR signal gav 2.03 biological objects in relation to the conditions of signal recording]. PMID- 4319325 TI - [Study of paramagnetic centers photoinduced in aqueous solutions of proteins]. PMID- 4319326 TI - [Possible role of acid-base equilibrium as a regulation factor for photochemical reactions of chlorophyll in vitro and in vivo]. PMID- 4319327 TI - [Study of the mechanism of photosensitized disintegration of glycine in the presence of tryptophan by electron paramagnetic resonance and luminescence methods]. PMID- 4319328 TI - [Membranes (ionic permeability, excitation, control)]. PMID- 4319329 TI - [Cell structures and cell function]. PMID- 4319330 TI - [Functional changes of nonheme iron in yeast cells]. PMID- 4319331 TI - [Control of mitochondria respiration during potentiating effects on the cell]. PMID- 4319332 TI - [Variations in the activity level in simple closed neuron chains]. PMID- 4319333 TI - [Localization of paramagnetic centers giving rise to the ESR signal with gav 2,03 in yeast cells]. PMID- 4319334 TI - Scleroedema of Buschke. An uncommon cause of cardiomyopathy. AB - A case of scleroedema of Buschke involving skin and myocardium in a 69-year old woman is described. Widespread electrocardiographic abnormalities were present at the height of the disease, which improved over 18 months as the mucopolysaccharide infiltration of the skin cleared. PMID- 4319335 TI - [Motor neuron disease and related disorders]. PMID- 4319336 TI - [Effect of consecutive switching-on of neurons in the abdominal nerve cord of the freshwater crayfish]. PMID- 4319338 TI - Impulsive and basal ACTH secretion phases in normal subjects, in obese subjects with signs of adrenocortical hyperfunction and in hyperthyroid patients. PMID- 4319337 TI - The growth of liver parenchymal nuclei and its endocrine regulation. PMID- 4319339 TI - A reproducible, reliable method for determination of progesterone (P) and 20 alpha-dihydroprogesterone (20 alpha P) in small volumes of plasma or serum, suitable for a range of concentrations from follicular phase to late pregnancy values. Levels found throughout a normal human pregnancy. PMID- 4319340 TI - Pituitary response to insulin-induced hypoglycemia in obese subjects before and after fasting. PMID- 4319341 TI - Plasma renin activity and aldosterone secretory rate in man during chronic ACTH administration. PMID- 4319342 TI - A case of ACTH-secreting cancer of the colon. PMID- 4319343 TI - The effect of medium components on the specificity of axenic Entamoeba histolytica antigen. PMID- 4319344 TI - Improved method for the monoxenic cultivation of Entamoeba histolytica Schaudinn, 1903 and E. histolytica-like amebae with trypanosomatids. PMID- 4319345 TI - Comparative effects of cortisone and ACTH on golden and chinese hamsters infected with Trichinella spiralis. PMID- 4319346 TI - Techniques of axenic cultivation of Entamoeba histolytica Schaudinn, 1903 and E. histolytica-like amebae. PMID- 4319348 TI - Reduced adjuvant activity of Bordetella pertussis on the secondary immune response of mice evoked by an immunogenic threshold dose of sheep erythrocytes. PMID- 4319347 TI - [Activity of some enzymes of tissue respiration in developing resistance to DDT in Musca domestica under the effect of sublethal doses]. PMID- 4319349 TI - Biological significance of the prostaglandins. PMID- 4319350 TI - The hormonal control of hepatic gluconeogenesis. PMID- 4319352 TI - Hormone-secreting and hormone-responsive cell cultures. PMID- 4319351 TI - Regulation of adipose mass: control of fat cell development and lipid content. PMID- 4319353 TI - Influences of the in vivo and in vitro hormonal environment upon luteinization of granulosa cells in tissue culture. PMID- 4319354 TI - Lipid composition of bovine retinal outer segment fragments. PMID- 4319355 TI - [Change of the macrostructure of spin-labelled bovine serum albumin under gamma irradiation]. PMID- 4319356 TI - [Interpretation of electron paramagnetic resonance spectra from plant lipids]. PMID- 4319357 TI - [Evaluation of functional recombinations of intracellular microstructures using the Fisher information index]. PMID- 4319358 TI - [EPR spectra on non-lyophilized tissues animal]. PMID- 4319359 TI - [Theoretical analysis of the mechanisms of nerve impulse propagation along a non uniform fiber. 3. Transformation of the rhythms in cooled regions of the fiber]. PMID- 4319360 TI - [Mathematical model of excitation propagation in Purkinje fibers]. PMID- 4319361 TI - [Detection by the paramagnetic probe method of new structural transformations in the DNA-water system with temperature changes]. PMID- 4319362 TI - [Change in the condition of the respiratory chain of microsomes during poisoning by boron and its compounds]. PMID- 4319363 TI - Multiple myeloma associated with bone sclerosis and peripheral neuropathy. PMID- 4319364 TI - Rhinoviraemia. AB - Rhinoviruses have been isolated from the serum of two infants at necropsy. Failure to isolate viruses from ten other sera from infants who yielded rhinoviruses from their respiratory tracts suggests that true rhinoviraemia occurs rarely, and is infrequently associated with rhinovirus infections, both clinical and subclinical, and death. It is suggested that this is the first report of isolations of human rhinoviruses from the blood. PMID- 4319366 TI - [Identification of the types of foot-and-mouth disease virus. Quarterly cumulative report]. PMID- 4319365 TI - Force and kindred notions in eighteeth-century neurophysiology and medical psychology. PMID- 4319367 TI - [Identification of the types of foot-and-mouth disease virus. Nong-Sarsai (Thailand). Results of the diagnosis and identification of the foot-and-mouth disease virus]. PMID- 4319369 TI - Cytochrome oxidase activities of various cartilage tissues during growth and development. PMID- 4319368 TI - Investigations on cartilage and bone induction in mice grafted with FL and WISH line human amniotic cells. PMID- 4319370 TI - The in vitro hydroxylation of proline by silica powder. PMID- 4319371 TI - The inhibitory effect of phosphonates on the formation of calcium phosphate crystals in vitro and on aortic and kidney calcification in vivo. PMID- 4319372 TI - Gastroscopy and related diagnostic methods in gastric ulcer and carcinoma. PMID- 4319373 TI - Mechanisms of recovery from a generalized viral infection: mousepox. I. The effects of anti-thymocyte serum. AB - Agglutination and immunofluorescence tests in vitro showed that the ATS used in these experiments cross-reacted with macrophages and RBC. However, ATS was not toxic in vivo, and small doses given subcutaneously depleted thymus-dependent areas of lymphoid tissues and selectively depressed blood lymphocyte counts without affecting other cell types in the blood. Furthermore, the function of littoral macrophages as indicated by the clearance of blood-borne virus and its subsequent behavior over a 48 hr period in the liver and spleen was not changed by ATS. Thus, the innate resistance of these vital target organs was not depressed. A similar regimen of subcutaneous ATS caused a highly significant increase in mortality from mousepox with an associated failure to control virus growth in the liver and spleen which was manifest by 6 days after infection. The interferon and neutralizing antibody responses were not impaired in ATS-treated mice, but the cell-mediated immune response was significantly suppressed. This evidence, and consideration of the timing of these host responses during the course of infection in relation to the control of virus growth in the liver and spleen, led to the conclusion that cell-mediated immunity probably contributed an essential acquired recovery mechanism. However, no evidence was obtained concerning the nature of this antiviral mechanism. PMID- 4319374 TI - Focal recording of responses evoked by light in the lamina ganglionaris of the fly Sarcophaga bullata. PMID- 4319375 TI - Serologic evidence that infectious canine hepatitis virus commonly infects humans and is related to human adenovirus type 8. PMID- 4319376 TI - Herpes-like virus (EB virus) in continuous lymphoblastoid cell lines from patients with viral hepatitis. PMID- 4319377 TI - [Japanese encephalitis in recent years--cases confirmed as true Japanese encephalitis in the last 5 years (1965-69). 2. Clinical pictures (manifestations in acute stage, transient syndrome and sequelae)]. PMID- 4319378 TI - Biochemical observations of Ascaris suum lung-stage larvae. PMID- 4319379 TI - Cytological studies on the absorptive surfaces of cestodes. 3. Hydrolysis of phosphate esters. PMID- 4319381 TI - Luteoma of pregnancy. PMID- 4319380 TI - Classification of Entamoeba species by means of electrophoretic properties of amebal enzymes. PMID- 4319382 TI - Granuloma formation in lymph-nodes. PMID- 4319384 TI - [After care of patients following rheumatic fever]. PMID- 4319383 TI - Ethambutol and viomycin. PMID- 4319385 TI - The pharmacology of disturbed sleep. PMID- 4319386 TI - Tumour specific antigens associated with chemically induced tumours. PMID- 4319387 TI - [A new method for differential diagnosis of peripheral lesions and central lesions of the vestibulo-oculomotor pathways]. PMID- 4319388 TI - Radioreceptor assay of adrenocorticotropic hormone: new approach to assay of polypeptide hormones in plasma. AB - Biologically active iodine-125-labeled adrenocorticotropic hormone (ACTH) binds specifically to ACTH receptors extracted from adrenals. Unlabeled ACTH at 1 picogram per milliliter significantly displaces labeled ACTH from these receptors. This system, which appears to be applicable to all polypeptide hormones, provides a rapid and sensitive method for measurements of biologically active ACTH in dilute whole plasma. PMID- 4319389 TI - [Role of the dorsal regions of the hippocampus in the conduction of visceral and exteroceptive signals into the cerebral cortex]. PMID- 4319390 TI - [Enzyme studies in follicular and cystic fluids of the human ovary]. PMID- 4319391 TI - [The determination of 17-hydroxycorticosteroids in urine using sodium metaperiodate]. PMID- 4319392 TI - [A simplified method for the determination of renin activity in human plasma]. PMID- 4319393 TI - [Studies on the ribosomal ferritin of normal, cirrhotic and carcinomatous human livers]. PMID- 4319394 TI - Copper deficiency in chicks: effects of ascorbic acid on iron, copper, cytochrome oxidase activity, and aortic mucopolysaccharides. PMID- 4319395 TI - [Periods of administration of aflatoxin-containing diet and hepatoma in the rainbow trout]. PMID- 4319396 TI - Organ cultures inoculated with serum from a hepatitis patient with Au antigenemia. PMID- 4319397 TI - [Epidemiology of coronary diseases, a study program]. PMID- 4319398 TI - Studies on poly (adenosine diphosphate ribose). V. Mechanism of hydrolysis of poly (adenosine diphosphate ribose) by snake venom phosphodiesterase. PMID- 4319399 TI - Properties and regulation of glutathione peroxidase. PMID- 4319400 TI - [Anti-EB virus titer in serum of patients with otorhinolaryngology cancer]. PMID- 4319401 TI - [Occurrence and significance of adenovirus infections]. PMID- 4319402 TI - Pattern of necrosis in acute viral hepatitis. Prognostic value of bridging (subacute hepatic necrosis). PMID- 4319403 TI - Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 47-1970. PMID- 4319404 TI - [Autopsy case of stomach cancer with marked eosinophilia]. PMID- 4319405 TI - [Autopsy case of glioblastoma multiforme initially with gastrointestinal symptoms and subsequent syndrome of meningitis, together with review of literature]. PMID- 4319406 TI - [Chemodectoma of the orbit]. PMID- 4319407 TI - [Oxoline in virus diseases of the conjunctivae and cornea]. PMID- 4319408 TI - [Sporadic goiter and congenital deafness. Pendred's syndrome]. PMID- 4319409 TI - [Sporadic goiter and congenital deafness. Pendred's syndrome. 15 cases]. PMID- 4319410 TI - [Viral-genetic concept of tumor development (experimental evidence)]. PMID- 4319411 TI - [Genetic markers of herpes simplex virus. 1. Some genetic markers of K strain of herpes simplex virus of the 2d antigenic group]. PMID- 4319412 TI - [Chromatographic characteristics of poliomyelitis virus variants on cellulose ion exchangers]. PMID- 4319413 TI - [Genetic markers of herpes simplex virus. 2. Study of genetic markers of the US strain of herpes simplex virus of the 3d antigenic group]. PMID- 4319414 TI - [Electron microscopic study of the epithelium of the upper respiratory passages in patients with acute respiratory virus infections]. PMID- 4319415 TI - [Nature of intranuclear herpetic inclusions]. PMID- 4319416 TI - [New antigens induced by Sendai virus in cells of different species]. PMID- 4319417 TI - [Serological examinations of some species of wild and domestic birds for prevalence of infectious and oncogenic avian viruses]. PMID- 4319418 TI - [Tumors and cysts in reptiles due to fowl sarcoma virus]. PMID- 4319419 TI - [Use of the virus-deproteinizing capacity of cells for production of viral ribonucleoprotein]. PMID- 4319421 TI - [Unusual pain syndrome in otogenic intracranial complication]. PMID- 4319420 TI - [Effect of incubation temperature on the development of specific lesions caused by smallpox virus]. PMID- 4319422 TI - [Steroids. 13. Conversion of 7-bromocholesteryl benzoate on silica gel]. PMID- 4319423 TI - [Role of metals in the lecithinase activity of Cl. perfringens]. PMID- 4319424 TI - [Tumor lipids. Phospholipid distribution in mitochondria and microsomes of the solid rat hepatoma-27 and mouse hepatoma-22]. PMID- 4319425 TI - [Protein synthesis in paramyxovirus-infected cells of susceptible and resistant lines at the early stage of infection]. PMID- 4319426 TI - [Effect of Cl. perfringens collagenase on some synthetic substrates]. PMID- 4319427 TI - [Formation of an intermediate compound during hydrolysis of the substrate of yeast inorganic pyrophosphatase]. PMID- 4319428 TI - [Effect of Clostridium histolyticum collagenase on hexa- and polypeptides]. PMID- 4319429 TI - [Changes in a culture of green monkey lung cell cultures under the influence of simian virus 40]. PMID- 4319430 TI - [Electrotonic potentials of the primary terminals of the vagus nerve and the inhibitory Hering-Breuer reflex]. PMID- 4319431 TI - [Various mechanism of the influence of the hypothalamus on the tumor process]. PMID- 4319432 TI - [The activity of various phosphatases in the normal and regenerated livers of pregnant rats]. PMID- 4319433 TI - [The morphology and histochemistry of the hemochorial placentas of white rats following nitrobenzene poisoning of the mother]. PMID- 4319434 TI - Electroencephalographic and electromyographic changes in a case of angiokeratoma corporis diffusum (Fabry's disease). PMID- 4319435 TI - Proteolytic enzymes in sea urchin eggs: characterization, localization and activity before and after fertilization. PMID- 4319436 TI - The possible mediation by cyclic AMP of the stimulation of thymocyte proliferation by vasopressin and the inhibition of this mitogenic action by thyrocalcitonin. PMID- 4319438 TI - [Synovial sarcomas in children]. PMID- 4319437 TI - [Radiculography with emulsions of ethyl mono-iodo-stearate]. PMID- 4319439 TI - [Primary cancer of the liver in children]. PMID- 4319440 TI - [Aortography and lymphadenography in children with retroperitoneal neoplasms]. PMID- 4319443 TI - [Aspiration puncture using a fine needle as a diagnostic method for liver tumors]. PMID- 4319441 TI - The treatment of dermatological infections with a manganese phenanthroline chelate. A controlled clinical trial. PMID- 4319442 TI - In-vitro sensitivity of 368 urinary organisms to trimethoprim-sulphamethoxazole and other antibacterials. PMID- 4319444 TI - [Monoaminergic neuron]. PMID- 4319445 TI - [Post partum paralysis of the common peroneal nerve. Case report]. PMID- 4319446 TI - [Differentiation of lamellar inclusions in the chick embryonic lung]. PMID- 4319447 TI - Palpation of the breast. A part of the precordial examination. PMID- 4319448 TI - Influence of steroids on human myometrial contractility and myometrial response to catecholamines. PMID- 4319449 TI - Phosphorus compounds of radioresistant and radiosensitive yeasts. PMID- 4319450 TI - Localization and physiological role of inorganic polyphosphates in the cells of Endomyces magnusii. PMID- 4319451 TI - General scheme for the metabolisation of hydrocarbons by Candida tropicalis. PMID- 4319452 TI - Control of respiration and aerobic fermentation in Saccharomyces cerevisiae. PMID- 4319453 TI - Effect of acetoin on anaerobic growth in Brettanomyces. PMID- 4319454 TI - Changes in chemical and enzymatic composition during enzymatic digestion of isolated yeast cell walls containing plasma membrane. PMID- 4319456 TI - Cytochromes from Mycobacterium phlei. I. Isolation and spectral properties of a mixture of cytochromes (a + a3) (o). PMID- 4319455 TI - Hydroxylation of proline residues in collagen nascent chains. PMID- 4319457 TI - Escherichia coli B cobalamin methyltransferase: ability of diaphorases and lipoamide dehydrogenases to function as reducing agents. PMID- 4319458 TI - Phosphatase activity stimulated by Na+ plus K+: implications for the (Na+ plus K+)-dependent adenosine triphosphatase. PMID- 4319459 TI - Purification of deoxyribonuclease II from sheep spleen. PMID- 4319460 TI - Interactions between monovalent cations and the (Na+ + K+)-dependent adenosine triphosphatase. PMID- 4319461 TI - Rabbit liver and rabbit kidney fructose diphosphatases: catalytic properties of enzymes activated by coenzyme A and acyl carrier protein. PMID- 4319462 TI - Equilibrium and rate constants for the reaction between NADH and horse liver alcohol dehydrogenases "EE," "ES," and "SS". PMID- 4319463 TI - NAD-dependent L-fucose dehydrogenase from sheep liver. PMID- 4319464 TI - [Dynamics of destructive and restorative processes in the interneuron synapses]. PMID- 4319465 TI - Experimental encephalomyocarditis virus infection in calves. PMID- 4319466 TI - Reaction of myosin with salicylaldehyde. II. Effect of salicylalation of the ATPase activity of myosin. PMID- 4319467 TI - Inhibition of respiration in yeast by light. PMID- 4319468 TI - Inhibition of respiration and destruction of cytochrome A3 by light in mitochondria and cytochrome oxidase from beef heart. PMID- 4319469 TI - Detection of cross-reactions by immunofluorescence within the picornavirus group. PMID- 4319470 TI - CO2 control of fruiting in Schizophyllum commune: noninvolvement of sustained isocitrate lyase derepression. PMID- 4319471 TI - Antigen-sensitive spleen cells and the adjuvant activity of Bordetella pertussis. PMID- 4319472 TI - [Distribution and activity of phosphomonoesterases in the cutis of unaffected psoriatic skin]. PMID- 4319473 TI - On the crystal deposition diseases. PMID- 4319474 TI - Biological activities of sonically treated Sendai virus. PMID- 4319475 TI - Characterization of foot-and-mouth disease virus ribonucleic acid synthesized in vitro. PMID- 4319476 TI - Identification of a central site of action of angiotensin II. PMID- 4319477 TI - Drug-induced secretion of catecholamines by the perfused adrenal gland of the dog during nicotine blockade. PMID- 4319478 TI - Behavioral studies of sleep patterns in alcoholics during intoxication and withdrawal. PMID- 4319479 TI - Proteins of vesicular stomatitis virus. II. Immunological comparisons of viral antigens. AB - The antigens of the nucleoprotein core and the coat of vesicular stomatitis virus (VSV) particles of the Indiana serotype were prepared and purified by sucrose gradient fractionation. Antibody was prepared separately to each of the two antigen fractions. By immunological procedures, it was shown that soluble antigens of VSV preparations sedimenting at 20S and in the leading edge of the 6S region are antigenically related to VP3, the protein of the virus core, whereas the 6S soluble antigen cross-reacts only with viral coat antibodies. These results confirm previous results obtained by polyacrylamide gel analysis of the antigens. It has further been demonstrated that the 6S antigen is a glycoprotein. Comparing antigens of the New Jersey and Indiana serotype showed that the coat antigens of virus particles and the 6S antigen are immunologically distinct in the two serotypes. In complement-fixation tests, the core antigens and the soluble 20S antigens from one serotype showed a cross-reaction with antiserum prepared against core proteins of the other serotype. PMID- 4319480 TI - Deoxyribonucleotide pools and deoxyribonucleic acid synthesis in mouse embryo cells infected with three classes of polyoma virus particles. AB - Polyoma virus particles were purified by equilibrium centrifugation in CsCl. Particles from three regions of the density gradient were examined for infectivity, for their ability to induce expanded pools of deoxyribonucleic acid (DNA) precursors, and for their ability to stimulate the synthesis of DNA. The most infectious population of particles, the virions, having a buoyant density of 1.33 g/ml, gave the greatest stimulation of the DNA-synthesizing apparatus of mouse embryo cells. Empty particles at density 1.29 g/ml had no DNA stimulatory activity. A population of particles of intermediate density, referred to as pseudovirions, was also much less active than virions in stimulating DNA synthesis, and the limited stimulatory activity of the latter fraction may be accounted for by its measured contamination with infective particles. PMID- 4319481 TI - Identification of the simian virus 40 which replicates when simian virus 40 transformed human cells are fused with simian virus 40-transformed mouse cells or superinfected with simian virus 40 deoxyribonucleic acid. AB - Simian virus 40 (SV40) was rescued from heterokaryons of transformed mouse and transformed human cells. To determine whether the rescued SV40 was progeny of the SV40 genome resident in the transformed mouse cells, the transformed human cells, or both, rescue experiments were performed with mouse lines transformed by plaque morphology mutants of SV40. The transformed mouse lines that were used yielded fuzzy, small-clear, or large-clear plaques after fusion with CV-1 (African green monkey kidney) cells. The transformed human lines that were used did not release SV40 spontaneously or after fusion with CV-1 cells. From each mouse-human fusion mixture, only the SV40 resident in the transformed mouse cells was recovered. Fusion mixtures of CV-1 and transformed mouse cells yielded much more SV40 than those from transformed human and transformed mouse cells. The rate of SV40 formation was also greater from monkey-mouse than from human-mouse heterokaryons. Deoxyribonucleic acid (DNA) from SV40 strains which form fuzzy, largeclear, or small-clear plaques on CV-1 cells was also used to infect monkey (CV-1 and Vero), normal human, and transformed human cell lines. The rate of virion formation and the final SV40 yields were much higher from monkey than from normal or transformed human cells. Only virus with the plaque type of the infecting DNA was found in extracts from the infected cells. Two uncloned sublines of transformed human cells [W18 Va2(P363) and WI38 Va13A] released SV40 spontaneously. Virus yields were not appreciably enhanced by fusion with CV-1 cells. However, clonal lines of W18 Va2(P363) did not release SV40 spontaneously or after fusion with CV 1 cells. In contrast, several clonal lines of WI38 Va13A cells did continue to shed SV40 spontaneously. PMID- 4319482 TI - [Effect of kidney transplantation on the functional changes of the peripheral nervous system]. PMID- 4319483 TI - [Erythrocytosis in primary cancer of the liver]. PMID- 4319484 TI - [Endocrine metabolic paraneoplasms in bronchogenic cancer]. PMID- 4319485 TI - Further studies on steroidogenesis. 8. Glycolytic breakdown of glucose-6 phosphate and 11-beta-hydroxylation of 11-deoxycorticosterone in a cell free preparation of the rat adrenal gland. PMID- 4319486 TI - [Treatment of Itsenko-Cushing disease by yttrium-90 implantation in the hypophysis]. PMID- 4319487 TI - [The composition of the fluid of cystic brain tumors of different histological nature]. PMID- 4319488 TI - [Normal fundi oculi in tumors of the posterior cranial fossa]. PMID- 4319489 TI - [A combination of arachnoendothelioma and glioblastoma multiforme of the brain]. PMID- 4319490 TI - [Use of oleagenous contrast preparations in myelography (a review of the foreign literature)]. PMID- 4319491 TI - [Indication for hospital admission of surgical patients in with cognition disorders]. PMID- 4319493 TI - The ultrastructure of the parathyroid glands of young pigs. PMID- 4319492 TI - [Pathoplastic factors in vascular diseases of the peripheral nervous system (review of the literature)]. PMID- 4319494 TI - [Studies on the suitability of tissue culture neutralization tests in the government etesting of adsorbed foot-and mouth disease vaccines. 1. The content of neutralizing antibody in the serum of cattle after vaccination with adsorbed vaccine against type O2 virus in comparison with the direct immunity testing in cattle]. PMID- 4319495 TI - [Studies on pigs. XXX. Relationships between the concentrations of 11 hydroxycorticosteroid and glucose in the plasma and the number of eosinophile leucocytes in the blood]. PMID- 4319497 TI - Herpesvirus hominis encephalitis. Neurological manifestations and use of idoxuridine. PMID- 4319496 TI - [Activity of aldolase (1,6-diphosphofructaldolase) in the serum, erythrocytes, and liver of pigs after administration of ACTH, DOCA, and prednisolone, and following adrenalectomy]. PMID- 4319498 TI - Isolation and chemical characterization of phosphatidylglycerol from blood plasma of humans. PMID- 4319499 TI - Effects of nagarse, adenosine and hexokinase on palmitate activation and oxidation. PMID- 4319500 TI - [Chemiluminescence connected with the formation of lipid peroxides in biological membranes. IV. Role of the change of iron valency in these processes]. PMID- 4319501 TI - [Extracellular recorded action potentials and the possibility of excitation propagation along the dendrites]. PMID- 4319502 TI - [The cytochemistry of herpetic infections of human embryo fibroblast cultures]. PMID- 4319503 TI - [The mechanism of reserpine action on the hypophyseal-adrenal cortex system]. PMID- 4319504 TI - [The effect of biomycin on liver tumor induction in mice]. PMID- 4319505 TI - Studies on the oxidative fraction of rabbit muscle glyceraldehyde-3-phosphate dehydrogenase. Influence of ligands on its obtention enzymic properties. PMID- 4319506 TI - [Conformation-induced circular dichroism in hemoglobin of Chironomus th. thummi]. PMID- 4319507 TI - Concentration of cyclic 3':5'-adenosine monophosphate and glycogen metabolism in the liver. PMID- 4319508 TI - [Etiopathogenesis of leukemia]. PMID- 4319509 TI - Recent advances in neurosurgical treatment for the elderly. PMID- 4319510 TI - Electron microscopic studies of Wallerian degeneration in rat optic nerves. I. The multipotential glia. PMID- 4319511 TI - Effects of tetracosactrin on plasma corticosteroids in subjects of different body build. PMID- 4319512 TI - Stabilization of cytochrome oxidase activity of rat skin and gingiva by dimethyl sulfoxide and Ficoll. PMID- 4319513 TI - Acetylcholine. PMID- 4319514 TI - Pseudo-transmitters. PMID- 4319515 TI - Role of hypothalamic monoamines in the control of pituitary secretions. PMID- 4319516 TI - The importance of monoamine metabolism for the pathology of the extrapyramidal system. PMID- 4319519 TI - [The cyclic AMP function in effects of radiation protective agents]. PMID- 4319518 TI - Viral leukemogenesis in immunologically and hematologically altered mice. PMID- 4319517 TI - Acetonitrile-Diatomaceous earth column for corticosteroids. PMID- 4319520 TI - Electron spin resonance of malignant human tissue. PMID- 4319521 TI - Studies of the spontaneous myocardiopathy in the BIO-14.6 strain of hamster. PMID- 4319522 TI - Liver cancer in Bedouins of the Negev. An etiological and morphological study. PMID- 4319523 TI - Tumor conference from University of Colorado Medical Center. PMID- 4319524 TI - [The oxygen pressure field in normal and pathologically altered muscle]. PMID- 4319525 TI - Observations on some possible causes of variation in the titre of Brucella antibodies in cattle. PMID- 4319526 TI - Canine herpesvirus respiratory infection. PMID- 4319527 TI - Presence of natural haemagglutinins to sheep erythrocytes in sera from chickens free from Marek's disease. PMID- 4319528 TI - Foot-and-mouth disease virus in milk: an epidemiological study. PMID- 4319529 TI - [Induction of cellular DNA synthesis by oncogenic viruses]. PMID- 4319530 TI - [Detection of antibodies to oncogenic and non-oncogenic adenoviruses in the sera of green monkeys]. PMID- 4319531 TI - [Smallpox vaccine inactivated by gamma-rays: its antigenic and immunogenic properties]. PMID- 4319532 TI - [A precipitating antigen in the blood of mice infected by arboviruses]. PMID- 4319533 TI - [An RNA-polymerase inhibitor formed in virus infected cells. A simple method of determining inhibitor activity]. PMID- 4319534 TI - The otomicroscopic observation and its clinical application. PMID- 4319535 TI - Effects of secretin on fat mobilizing lipolysis and cyclic AMP levels in rat adipose tissue. PMID- 4319536 TI - Releasing effect of calcium and phosphate on catecholamines, ATP, and protein from chromaffin cell granules. PMID- 4319537 TI - The hemodynamic importance of structural vascular changes in essential hypertension. PMID- 4319538 TI - Effect of ethanol, thyrxine and fructose on the intracellular redox state of a perfused liver as studied by surface fluorometry. PMID- 4319539 TI - Purification and general properties of glutamate decarboxylase from Clostridium perfringens. AB - 1. A seven-step procedure for preparing highly purified glutamate decarboxylase from Clostridium perfringens is described. 2. The homogeneity of the pure enzyme was established by sucrose-density-gradient centrifugation and starch-gel electrophoresis. 3. The isoelectric point of the pure enzyme is about pH4.5 and the molecular weight is 290000. 4. The pH optimum for activity is 4.7. The pure enzyme is specific for l-glutamate; beta-hydroxyglutamate is decarboxylated at a lower rate. 5. Evidence is presented that each mol of enzyme contains 2mol of firmly bound pyridoxal 5-phosphate. 6. Resolution does not occur at acid pH; by dilution with neutral or alkaline buffers the enzyme is inactivated and the coenzyme is released. 7. Reconstitution of active enzyme was obtained by protecting the apoenzyme with thiol compounds. PMID- 4319541 TI - Pyruvate kinase of hepatoma Morris 5123: insensitivity to dietary changes. PMID- 4319540 TI - The characterization and stereochemistry of biosynthesis of dolichols in rat liver. AB - It was shown that rat liver contains a series of dolichols with chain lengths of from 17 (or possibly 16) to 21 isoprene residues, the main constituent of the mixture being dolichol-18. By using double-labelled radioactive mevalonates it was demonstrated that each of these dolichols possesses three biogenetically trans-isoprene residues and that the remaining residues are biogenetically cis, suggesting that these polyprenols are biosynthesized from all-trans-farnesyl pyrophosphate by the cis additions of isoprene residues, followed by saturation of the alpha-isoprene residue. The results obtained with these radioactive mevalonates also indicated that the activity of isopentenylpyrophosphate isomerase is low relative to the activity of prenyltransferase in rat liver. PMID- 4319542 TI - Interaction of dehydroheliotridine, a metabolite of heliotridine-based pyrrolizidine alkaloids, with native and heat-denatured deoxyribonucleic acid in vitro. AB - Dehydroheliotridine, a major pyrrolic metabolite of heliotridine-based pyrrolizidine alkaloids, interacted with both native and heat-denatured DNA in vitro under mildly acid conditions to form a soluble non-diffusible complex as shown by spectral data. The complex formed with heat-denatured DNA was more resistant than heat-denatured DNA alone to the combined action of deoxyribonuclease and phosphodiesterase. Analysis of the resistant fractions suggested the presence of at least one base not obtained from DNA alone. PMID- 4319543 TI - Adenosine 3':5'-cyclic monophosphate and catabolite repression in Escherichia coli. AB - 1. Both permanent and transient catabolite repression of beta-galactosidase synthesis in Escherichia coli are abolished by 5mm-3':5'-cyclic-AMP when elicited by glucose, but not when caused by a mixture of glucose, glucose 6-phosphate, gluconate and casein hydrolysate (casamino acids). 2. Glucose uptake is slightly increased by 3':5'-cyclic-AMP. 3. No significant effects of the nucleotide were found on the synthesis of protein and RNA, either in exponential growth on one substrate, or during a growth shift from glycerol to glycerol plus glucose. 4. Marked changes in the soluble-protein profiles of cells growing in glycerol and glucose were caused by the presence of 3':5'-cyclic-AMP. 5. Measurements of (14)CO(2) release from specifically-labelled glucose showed that 3':5'-cyclic-AMP greatly stimulated glycolytic activity while having a minor depressing effect on the metabolic flow through the pentose phosphate cycle. 6. The concentrations of several metabolic intermediates, particularly fructose 1,6-diphosphate, were greatly affected by the presence of 3':5'-cyclic-AMP. 7. Several metabolites partially relieved glucose repression of beta-galactosidase synthesis in EDTA treated cells; three out of five of these metabolites reversed the effect more effectively than did 3':5'-cyclic-AMP. 8. The evidence for and against a direct role for 3':5'-cyclic-AMP is discussed. It is concluded that the evidence for indirect action is at least as strong as that for direct action. PMID- 4319544 TI - Interactions between metabolic intermediates and beta-galactosidase from Escherichia coli. AB - 1. 5-Phosphorylribose 1-pyrophosphate, in the presence of beta-mercaptoethanol, protected beta-galactosidase from heat inactivation. Many other substances, including 3':5'-cyclic-AMP, were without effect. 2. The efficiency of complementation in vitro of beta-galactosidase segments was decreased by 5 phosphorylribose 1-pyrophosphate but not by 3':5'-cyclic-AMP. Neither substance affected the activity of the complete enzyme. 3. Some indications as to the possible identity of the catabolite repression effector are presented. PMID- 4319545 TI - Effects of 3-methylcholanthrene pretreatment on microsomal hydroxylation of 2 acetamidofluorene by various rat hepatomas. AB - 1. The effects of 3-methylcholanthrene pretreatment on both N- and ring hydroxylation of 2-acetamidofluorene by microsomal preparations from various well differentiated and poorly differentiated hepatomas, primary tumours and their host livers and kidneys were studied. 2. Well-differentiated Morris hepatomas 5123C, 5123D, 5123CTC and 7800 and their host livers had low hydroxylating activity. Pretreatment with 3-methylcholanthrene caused a several-fold increase in both N- and ring hydroxylation in the host livers whereas in all tumours except 5123CTC it caused a many-fold increase only in ring hydroxylation. 5123CTC tumour in addition showed a fourfold increase in N-hydroxylating activity. 3. Hydroxylating activities of poorly differentiated Morris hepatoma 7288CTC and Novikoff hepatoma were low and they could not be altered by 3-methylcholanthrene pretreatment. 4. Primary hepatomas produced by administration of 4-dimethylamino 3'-methylazobenzene could be stimulated to some extent on 3-methylcholanthrene pretreatment; however, primary mammary tumour produced by administration of 3 methylcholanthrene was not responsive to 3-methycholanthrene pretreatment. 5. Like host livers, kidneys of tumour-bearing animals could also be stimulated to some extent by 3-methylcholanthrene pretreatment. PMID- 4319546 TI - Microbial degradation of 4-carboxy-1-methyl-pyridinium chloride, a photolytic product of paraquat. PMID- 4319547 TI - Benzoate oxidation by bacterium N.C.I.B. 8250. PMID- 4319548 TI - The locations of cathepsin activity and beta-glucuronidase in the Guerin T8 tumour. AB - Tumour homogenate fractions, isolated by differential centrifugation, were subfractionated by density-gradient centrifugation. Biochemical and electron microscopic analyses revealed that beta-glucuronidase and cathepsin activity were associated with a class (possibly two) of lysosomal particles of density greater than those of mitochondria and the endoplasmic reticulum. Lysosomes sedimented by low g forces were vacuolar, electron-dense, delineated by a unit membrane and about 0.2mum in diameter. beta-Glucuronidase was also apparently associated with ribosomes whereas cathepsin was bound in part to the endoplasmic reticulum. Catalase and glucose 6-phosphatase possessed slightly different density-gradient sedimentation profiles. PMID- 4319549 TI - Porcine polioencephalomyelitis associated with a serological response to porcine enterovirus F.26 in Tasmania. PMID- 4319550 TI - Some properties of brain cell suspensions prepared by a mechanical-enzymic method. PMID- 4319552 TI - [Possible role of imidazole compounds in nerve activity processes (exemplified by histamine)]. PMID- 4319551 TI - [Phospholipids of cell membranes of liver and hepatoma in rats]. PMID- 4319553 TI - Platelet lipids. V. Saturated and unsaturated fatty acid composition of phospholipids from rabbit platelets incubated with different media. PMID- 4319554 TI - Ganglionic and cardiac actions of batrachotoxin. PMID- 4319555 TI - Heterogeneity of drug receptors in different segments of rabbit thoracic aorta. PMID- 4319556 TI - Synaptic excitation of red nucleus neurones by fibres from interpositus nucleus. PMID- 4319557 TI - The influence of milk tumour virus (MTV) on mammary glands and adrenals in castrate mice. PMID- 4319558 TI - Amyloid deposit in the carcinoma of breast. A case report. PMID- 4319559 TI - Phosphate contents of calf thymus histone fractions. PMID- 4319560 TI - Specificity of the valyl ribonucleic acid synthetase from Escherichia coli in the binding of valine analogues. PMID- 4319561 TI - Studies on heart phosphofructokinase. Nature of the enzyme desensitized to allosteric control by photo-oxidation and by acylation with ethoxyformic anhydride. PMID- 4319563 TI - Hydrolysis of cyclic guanosine and adenosine 3',5'-monophosphates by rat and bovine tissues. PMID- 4319562 TI - The reciprocal regulation of lipoprotein lipase activity and hormone-sensitive lipase activity in rat adipocytes. PMID- 4319564 TI - Studies on translocation. 3. Conditions necessary for the formation and detection of a stable ribosome-G factor-guanosine diphosphate complex in the presence of fusidic acid. PMID- 4319565 TI - Purification and properties of the alpha-ketoglutarate dehydrogenase complex of cauliflower mitochondria. PMID- 4319566 TI - The role of the calcium-troponin-tropomyosin complex in the activation of contraction. PMID- 4319567 TI - Inhibition of gluconeogenic enzymes by free fatty acids and palmitoyl coenzyme A. PMID- 4319568 TI - Effects of vasopressin, cyclic AMP, and theophylline on oxygen consumption of toad bladder "sacs". PMID- 4319569 TI - Further evidence that renin is not the intrarenal natriuretic hormone. PMID- 4319570 TI - The pituitary and sebaceous gland activity. PMID- 4319571 TI - Suppression of endogenous corticosteroid production by betamethasone. PMID- 4319572 TI - Adrenal steroid secretion in the koala (Phascolarctos cinereus). PMID- 4319573 TI - A possible role for the adenyl cyclase system in calcitonin release. PMID- 4319574 TI - Physiological studies on the hypothalamo-hypophysial-interrenal axis in Poecilia latipinna (Teleostei). PMID- 4319575 TI - The effect of angiotensin on rat intestinal fluid transfer. PMID- 4319576 TI - Comparison of tests of hypothalamo-pituitary-adrenocortical function in pituitary disease. PMID- 4319577 TI - The response of the sebaceous glands of hypophysectomized-castrated male rats to adrenocorticotrophic hormone and to testosterone. PMID- 4319578 TI - Further studies on the measurement of plasma progesterone by competitive protein binding. PMID- 4319579 TI - Separation and identification of eel prolactin by disc electrophoresis. PMID- 4319580 TI - [On the study of chronic bronchopathies. Contribution of histochemistry and histo enzymology]. PMID- 4319581 TI - Therapy in Wilms' tumor of childhood. PMID- 4319582 TI - [Clostridium perfringens type C]. PMID- 4319583 TI - Enzymatic destruction of bone in vitro. PMID- 4319584 TI - Renal failure in 1970. PMID- 4319585 TI - [Diagnostic value of contrast medium phlebography of the inferior vena cava in tumors of the abdominal cavity]. PMID- 4319587 TI - [Enzymology of resistant respiration]. PMID- 4319588 TI - [Ultracytochemical studies of phosphatase activities in the vicinity of the internal limiting membrane of the rat retina]. PMID- 4319586 TI - [Mucopolysaccharides of bone and cartilage tissue in normal and pathological conditions]. PMID- 4319589 TI - [Disc electrophoretic analysis of cerebrospinal fluid proteins in the disturbances of optic nerve. I. Comparison of cerebrospinal fluid at various sites in the cerebrospinal axis. With special reference to the cerebrospinal fluid in the chiasmatic cistern]. PMID- 4319591 TI - [Kinking of the cervical portion of the internal carotid (personal case)]. PMID- 4319590 TI - A new assay for measuring adenyl cyclase activity in intact cells. PMID- 4319592 TI - Calcium phosphate formation in vitro. I. Factors affecting initial phase separation. PMID- 4319593 TI - Calcium phosphate formation in vitro. II. Effects of environment on amorphous crystalline transformation. PMID- 4319594 TI - Adaptive alterations in Lactobacillus casei. II. Variation in the levels of aldolase in cells grown on glucose and ribose. PMID- 4319595 TI - Site II-specific inhibition of mitochondria oxidative phosphorylation by trehalose-6,6'-dimycolate (cord factor) of Mycobacterium tuberculosis. PMID- 4319596 TI - Preparation of cellular plant organelles from spinach leaves. PMID- 4319597 TI - Distribution and properties of phospholipase A of Culex pipiens fatigans. PMID- 4319598 TI - Biosynthesis of triphosphoinositide in rat kidney cortex. PMID- 4319599 TI - Observations on the conformation of human serum high-density lipoproteins using infrared spectroscopy, circular dichroism, and electron spin resonance. PMID- 4319600 TI - Biosynthetic studies on 8,9,13-triacetoxydocosanoic acid. In vivo incorporation of fatty acid precursors. PMID- 4319601 TI - Studies on the chemiluminescence from an O2 and/or HOOH adduct derived from the riboflavin-copper(I) chelate. PMID- 4319603 TI - Some factors affecting ribonucleic acid chain-length estimation with Bacillus subtilis Exonuclease. PMID- 4319602 TI - Isolation and characterization of bovine lactate dehydrogenase X. PMID- 4319604 TI - An extraordinary temperature dependence of the reovirus transcriptase. PMID- 4319605 TI - Inhibition of hepatic protein synthesis by alpha-methyl-DL-tryptophan in vivo. Further studies on the glyconeogenic action of alpha-methyltryptophan. PMID- 4319606 TI - Cyclic 3',5'-nucleotide phosphodiesterase of Serratia marcescens. PMID- 4319607 TI - Effect of dipicolinic acid on bacterial cyclic 3,5'-nucleotide phosphodiesterase. PMID- 4319609 TI - Studies on hog spleen N-acetylglucosamine kinase. I. Purification and properties of N-acetylglucosamine kinase. PMID- 4319610 TI - Assay of UDPG1cUA pyrophosphatase and its relation to transglucuronidation. PMID- 4319608 TI - Effects of cations and ouabain on thyroid adenyl cyclase. PMID- 4319611 TI - [Gluconeogenesis and glycolysis in the kidneys of normal rats and rats with alloxan diabetes]. PMID- 4319613 TI - Vasovagal faint in the supine position. PMID- 4319612 TI - Natural history and treatment of Wilms's tumour: an analysis of 335 cases occurring in England and Wales 1962-6. AB - Hospital records and other data relating to Wilms's tumour were analysed to elucidate both thenatural history of the disease and the effects of treatment, with special reference to actinomycin D. The age of maximum incidence was about 18 months; left-sided tumours were significantly more common than right-sided ones.Prognosis was related to stage of the disease at the initial operation and to the occurrence of metastasis. The three-year survival rate for cases having a nephrectomy was 35%; no child who did not have a nephrectomy survived.Recurrence of the tumour was observed in two-thirds of the cases, almost always within two years of the initial treatment, irrespective of the child's age. The three-year survival rate for this group was 11%.The effects of radiotherapy and chemotherapy are considered in detail. Very little improvement in survival rate could be ascribed to actinomycin D. The reasons for this and for the variations found in earlier reports on selected cases are possibly the addition of other components of treatment and differences in drug regimens. The findings suggest the need for controlled clinical trials. PMID- 4319614 TI - Government medical officer in Lesotho. PMID- 4319615 TI - [Changes in the impulse activity of cortical neurons during pharmacological blockade of ascending activating influences]. PMID- 4319616 TI - The role of cyclic 3'5'-AMP in the cardiac response to adrenaline. PMID- 4319618 TI - Distribution of phospholipids in the various organs of Labeo rohita. PMID- 4319617 TI - Drug receptor sites in the isolated superior cervical ganglion of the rat. PMID- 4319620 TI - Demonstration of a herpes-type virus in short-term cultured blood lymphocytes associated with Marek's disease. PMID- 4319619 TI - The enzymes of the embryonic nephron. PMID- 4319621 TI - Polymyxin sensitivity of Candida tropicalis. PMID- 4319622 TI - Lipids in cereals. 1. Pennisetum typhoideum. PMID- 4319623 TI - [Familial polymorphous erythemato-squamous trichophytosis due to Trichophyton rubrum]. PMID- 4319624 TI - The polymyxins. PMID- 4319625 TI - Depletion of erythrocyte phosphoribosylpyrophosphate in man. PMID- 4319626 TI - Cutaneous interferon production in patients with Hodgkin's disease and other cancers infected with varicella or vaccinia. PMID- 4319627 TI - The purine revolution. PMID- 4319628 TI - Interferon and herpes zoster. PMID- 4319629 TI - Differential binding properties of cytochrome c: possible relevance for mitochondrial ion transport. PMID- 4319630 TI - Biological activity of a polar metabolite of vitamin D. PMID- 4319631 TI - Unique biosynthesis by kidney of a biological active vitamin D metabolite. PMID- 4319632 TI - [Protein metabolism in trauma]. PMID- 4319634 TI - The pathogenesis of diabetes mellitus. PMID- 4319635 TI - Coagulation abnormalities associated with liver transplantation. PMID- 4319633 TI - ACTH and the metabolism of adrenal cell cultures. PMID- 4319636 TI - [Electron microscope detection of cytomegalovirus in clinical specimens from children with congenital infection]. PMID- 4319638 TI - [Ultrastructure of a new membrane-organelle and its function during the phagocytosis of quartz]. PMID- 4319637 TI - [Functional-biochemical characteristics of neuroglia]. PMID- 4319639 TI - [Diagnosis of intestinal protozoa infections]. PMID- 4319640 TI - [Therapeutic use of synthetic corticotropin in treatment of asthma; clinical experimental study]. PMID- 4319641 TI - Recent advances in human steroid metabolism. PMID- 4319642 TI - A new aid to aging immature skeletons: development of the occipital bone. PMID- 4319643 TI - Effect of ACTH on biosynthesis of fibrinogen in the rabbit. PMID- 4319644 TI - Factors governing cutaneous vasoconstriction during hemorrhage. PMID- 4319645 TI - Effects of belladonna alkaloids on vestibular nucleus of the cat. PMID- 4319646 TI - Intestinal vasoconstriction after hemorrhage: roles of vasopressin and angiotensin. PMID- 4319647 TI - Uptake of oxytocin-3H by frog skin and bladder epithelial cells. PMID- 4319648 TI - Transcultural psychiatry in the Caribbean: past, present, and future. PMID- 4319649 TI - The role of brain dopamine in behavioral regulation and the actions of psychotropic drugs. PMID- 4319650 TI - [Technic of continuous intravenous drip infusion into cattle over prolonged periods]. PMID- 4319651 TI - [Isolation of a bovine adenovirus from enzootic cuffing pneumonia in calves]. PMID- 4319652 TI - [The agar-gel precipitation reaction in the field diagnosis of fowl pox]. PMID- 4319653 TI - [Applicability of tissue culture antigens to the detection of infectious bronchitis, infectious laryngotracheitis, fowl pox and CELO virus infection by the agar gel precipitation test]. PMID- 4319654 TI - [Evaluation of various methods for determining the potency of fowl pox vaccines]. PMID- 4319655 TI - [Must we let them die? Pleading for children with cancer]. PMID- 4319656 TI - Effects of ethacrynic acid on specific renal functions without and during angiotensin infusion in man. PMID- 4319657 TI - [The action of physiologic doses of synthetic ACTH in normal man]. PMID- 4319658 TI - Inhibition of ganglionic transmission by 4-methylpyridinium-N-fenacyloxime chloride. PMID- 4319659 TI - Effects of angiotensin on the function and metabolism of the ischemic kidney. PMID- 4319660 TI - Purification of the factor involved in thymidine phosphorylation in adult rat liver. PMID- 4319662 TI - Elution of mammalian nuclearsatellite DNA's on methylated albumin kieselguhr and hydroxyapatite chromatographic columns. PMID- 4319661 TI - Chromatography of nucleic acids on polynucleotide-coated kieselguhr. PMID- 4319663 TI - The kinetics of labelling and intracellular distribution of mammalian DNA-like RNA isolated by methylated albumin kieselguhr column chromatography. PMID- 4319664 TI - [Differentiation in vitro of a murine plasmacytoma: deomonstration of 2 cellular phenotypically stable stages]. PMID- 4319665 TI - Effect of dietary and hormonal factors on L-serine dehydratase and D-serine dehydratase activities of chicken liver and kidney. PMID- 4319666 TI - A note on cataplexy with simultaneous EEG-recordings. PMID- 4319667 TI - Infection and disease in a group of South Indian Families. IX. Poliovirus infection among pre-school children. PMID- 4319668 TI - Assessing physical maturity by scores for change in skeletal appearance. PMID- 4319669 TI - Puberty ratings in Ethiopian children. PMID- 4319670 TI - Metabolism of isolated fat cells. V. Preparation of "ghosts" and their properties; adenyl cyclase and other enzymes. PMID- 4319672 TI - Partial resolution of the enzymes catalyzing oxidative phosphorylation. XVI. Chemical modification of mitochondrial adenosine triphosphatase. PMID- 4319671 TI - Metabolism of isolated fat cells. VI. The effects of insulin, lipolytic hormones, and theophylline on glucose transport and metabolism in "ghosts". PMID- 4319673 TI - Amber mutants of bacteriophage T4 defective in deoxycytidine diphosphatase and deoxycytidine triphosphatase. On the role of 5-hydroxymethylcytosine in bacteriophage deoxyribonucleic acid. PMID- 4319674 TI - Oxidative phosphorylation in fractionated bacterial systems. XXIX. The involvement of nonheme iron in the respiratory pathways of Mycobacterium phlei. PMID- 4319675 TI - Steroid control of the normal development of glutamine synthetase in the embryonic chick retina. PMID- 4319676 TI - The effect of catecholamines on adenyl cyclase activity in rat uterus. PMID- 4319677 TI - Case for diagnosis. PMID- 4319678 TI - Localization and specificity of corticosteroid "feedback receptors" at the hypothalamo-hypophyseal level; comparative effects of various steroids implanted in the median eminence or the anterior pituitary of the rat. PMID- 4319679 TI - Intermolecular transfer of radiation energy at 77 degrees K. An ESR study of irradiated mixtures of macromolecules and oxidized penicillamine. PMID- 4319680 TI - Hydrogen transfer from exchangeable to carbon-bound sites in gamma-irradiated dry proteins. PMID- 4319681 TI - Radicals formed in proteins by reaction with hydrogen atoms. PMID- 4319682 TI - Transfer of interferon-producing macrophages: new approach to viral chemotherapy. AB - Mice were protected from infection with Semliki Forest virus and encephalomyocarditis virus by the transfer of peritoneal macrophages that were stimulated to produce interferon in vitro by exposure to a nonreplicating virus. This method of therapy was also utilized in animals infected with encephalomy ocarditis virus after onset of clinical signs. Of these animals 40 percent recovered, but only 9 percent of the control group recovered. PMID- 4319683 TI - Nonmetastatic extrapulmonary manifestations of bronchogenic carcinoma. PMID- 4319684 TI - [Intracecal infection of the mouse with entamoeba histolytica]. PMID- 4319685 TI - [Extraintestinal infection experiments in the golden hamster using entamoeba histolytica from bacteria-free cultures]. PMID- 4319686 TI - Effect of ethanol on uptake of choline by the isolated perfused rat liver. PMID- 4319687 TI - Antilipolytic activity of insulin and proinsulin on ACTH and cyclic nucleotide induced lipolysis in the isolated adipose cell of rat. PMID- 4319688 TI - Enzymatic estimation of galactose in the presence of galactolipids. PMID- 4319689 TI - Initial incorporation into rat liver glycerolipids of intraportally injected (9,10-3H2)palmitic acid. PMID- 4319690 TI - Motion of fatty acid spin labels in the plasma membrane of mycoplasma. PMID- 4319691 TI - Variations of NADH oxidase activity and bacteriochlorophyll contents during membrane differentiation in Rhodospirillum rubrum. PMID- 4319692 TI - Correlations between structure and spectroscopic properties in membrane model systems. Tryptophan and I-anilino-8-naphthalene sulfonate fluorescence in protein lipid-water phases. PMID- 4319693 TI - On the use of microsomal marker enzymes to distinguish the outer membrane of rat liver mitochondria from the microsomes. PMID- 4319694 TI - A study of the structural integrity of spin-labelled proteins in some fractions of human erythrocyte ghosts. PMID- 4319695 TI - A structural study of the modification of erythrocyte ghosts by phospholipase C. PMID- 4319696 TI - Nucleotide pyrophosphatase activity of rat liver plasma membranes. PMID- 4319698 TI - [Case of bilateral chemodectoma of carotid body]. PMID- 4319697 TI - Congenital agranulocytosis: prolonged survival and terminal acute leukemia. PMID- 4319699 TI - Short circuit theory on the onset of mental illness. PMID- 4319700 TI - Central vasomotor stimulation by angiotensin. PMID- 4319701 TI - The site of cardiovascular action of angiotensin II in the brain. PMID- 4319702 TI - Association of an enterovirus infection with a respiratory-enteric disease in an orphanage in Kampala, Uganda. PMID- 4319703 TI - [Changes in host specificity of tumor viruses]. PMID- 4319704 TI - Immunity against parainfluenza-3 virus in cattle. IgA in nasal secretions. PMID- 4319705 TI - Electron spin resonance studies of free radicals formed from orotic acid. PMID- 4319706 TI - [Therapeutic and prognostic problems in patients with nephroblastoma]. PMID- 4319707 TI - [Corticosteroids--intermittent treatment]. PMID- 4319708 TI - [Primary cancer of the lung in a 3 and one-half-year-old child]. PMID- 4319709 TI - Multiplication of Myxovirus parainfluenzae 1 (Sendai) in lung tissue culture of tortoise (Testudo graeca). PMID- 4319710 TI - Immunofluorescent detection of transmissible gastroenteritis virus in the intestines of piglets. PMID- 4319711 TI - Central neural regulation of antidiuretic hormone release and unit activity in the supraoptic nucleus of the behaving rhesus monkey. PMID- 4319712 TI - Localization of hypothalamic regulation of anterior pituitary function. PMID- 4319713 TI - Epidemiologic investigation of a smallpox outbreak in a town reported to be "100 per cent vaccinated". PMID- 4319715 TI - The influence of adrenaline and optical isomers INPEA on the adenylcyclase activity in brain hemispheres of rats in vitro. PMID- 4319714 TI - A two-year respiratory virus survey in four villages in West Bengal, India. PMID- 4319716 TI - Peripheral cholinergic blockade by drugs that block postsynaptic central inhibition. PMID- 4319717 TI - Effect of ions on inhibition of norepinephrine uptake by angiotensin. PMID- 4319718 TI - Immunological properties of Ascaris cuticle collagen. PMID- 4319719 TI - [Hormonal stimulation of adenyl cyclase activity of the ovary of a teleost fish, the goldfish (Carassius auratus L.)]. PMID- 4319720 TI - Inhibitory effect of diphtheria toxin on amino acid incorporation in Escherichia coli cell-free system. AB - The mechanism of action of diphtheria toxin in an Escherichia coli cell-free protein-synthesizing system was examined. When the washed ribosomes were incubated with toxin before addition of messenger ribonucleic acid (RNA), peptide syntheses of (14)C-phenylalanine directed by polyuridylic acid or phage R17 RNA were strongly inhibited by a small amount of toxin. Whereas, if the soluble fraction (105,000 x g supernatant fraction) was preincubated with toxin, no effect of toxin occurred either on the induced protein synthesis or on the activity of guanosine triphosphatase even in the presence of nicotinamide adenine dinucleotide. The binding of (3)H-formylmethionyl-transfer RNA to E. coli ribosomes directed by either R17 RNA or trinucleotide AUG was also decreased by toxin. These findings suggest that diphtheria toxin may prevent the binding of messenger RNA by successfully competing with the AUG for ribosomal binding sites. Sucrose-density gradient studies support this concept by showing the decrease in binding of (3)H-labeled R17 RNA to E. coli ribosomes exposed to toxin. PMID- 4319721 TI - Characterization and properties of the pyruvate phosphorylation system of Acetobacter xylinum. AB - The enzyme responsible for the direct phosphorylation of pyruvate during gluconeogenesis in Acetobacter xylinum has been purified 46-fold from ultrasonic extracts and freed from interfering enzyme activities. The enzyme was shown to catalyze the reversible Mg(2+) ion-dependent conversion of equimolar amounts of pyruvate, adenosine triphosphate (ATP), and orthophosphate (P(i)) into phosphoenolpyruvate (PEP), adenosine monophosphate (AMP), and pyrophosphate (PP). The optimal pH for PEP synthesis was pH 8.2; for the reversal it was pH 6.5. The ratio between the initial rates of the reaction in the forward and reverse directions was 5.1 at pH 8.2 and 0.45 at pH 6.5. The apparent K(m) values of the components of the system in the forward reaction were: pyruvate, 0.2 mm; ATP, 0.4 mm; P(i), 0.8 mm; Mg(2+), 2.2 mm; and for the reverse reaction: PEP, 0.1 mm; AMP, 1.6 mum; PP, 0.067 mm; Mg(2+), 0.87 mm. PEP formation was inhibited by AMP and PP. The inhibition by AMP was competitive with regard to ATP (K(i) = 0.2 mm). The reverse reaction was inhibited competitively by ATP and noncompetitively by pyruvate. The enzyme was strongly inhibited by p-hydroxymercuribenzoate. The inhibition was reversed by dithiothreitol and glutathione. The properties of the enzyme are discussed in relation to the regulation of the opposing enzymatic activities involved in the interconversion of PEP and pyruvate in A. xylinum. PMID- 4319722 TI - Mechanism of polymyxin B resistance in Proteus mirabilis. AB - The lipids from three types of organisms-a Proteus mirabilis wild type highly resistant to polymyxin B, a polymyxin B-sensitive mutant derived from the wild type, and the wild type grown in the presence of sulfadiazine resulting in phenotypic conversion to polymyxin B sensitivity-were examined to determine the nature of polymyxin B resistance. The phospholipid compositions were nearly identical; each organism contained similar small amounts of N-methyl phosphatidylethanolamine in addition to comparable quantities of phosphatidylethanolamine, phosphatidylglycerol, and cardiolipin. the fatty acid compositions were similar in the exponential phase of growth; in the stationary phase, sulfadiazine markedly inhibited the synthesis of cyclopropane fatty acids. Liposomes prepared from the dried lipids of the three types of organisms were extensively and similarly disrupted by the polymyxin. These findings suggest that polymyxin B resistance in P. mirabilis is determined by the cell envelope which prevents access of the antibiotic to the susceptible lipid target sites. PMID- 4319723 TI - Chromosomal location of the C gene involved in the biosynthesis of nicotinamide adenine dinucleotide in Escherichia coli K-12. AB - A gene involved in the synthesis of nicotinamide adenine dinucleotide has been found to be cotransducible with the genes involved in the utilization of arabinose (ara) and the biosynthesis of leucine (leu) and pantothenate (pan). Cotransduction frequency analysis places this nadC locus between leu and pan at approximately minute 1.5 on the genetic map of Escherichia coli. This gene codes for the enzyme, quinolate phosphoribosyl transferase, which catalyzes the conversion of quinolinic acid to nicotinic acid mononucleotide. PMID- 4319724 TI - Cytochemical localization of certain phosphatases in Escherichia coli. AB - Cytochemical studies of Escherichia coli at the light and electron microscopic levels have revealed alkaline phosphatase, hexose monophosphatase, and cyclic phosphodiesterase reaction products in the periplasmic space and at the cell surface. In preparations for both light and electron microscopy, reaction product filled polar caplike enlargements of the periplasmic space, such as those described in plasmolyzed cells, indicating significant terminal concentrations of these enzymes; dense substance was often seen within these polar caps in morphological specimens. Staining of the bacterial surface was commonly encountered, but could represent artifactual accumulation of precipitate along the cell wall. Alkaline phosphatase was demonstrated with several substrates (ethanolamine phosphate, glycerophosphate, p-nitrophenylphosphate, and glucose-6 phosphate) over a wide pH range in a bacterial strain (C-90) known to be constitutive for this enzyme, whereas strains deficient in this enzyme (U-7, repressed K-37), showed no activity with these substrates. Hexose monophosphatase and cyclic phosphodiesterase activities were characterized by reaction-product deposition with specific substrates at acid or neutral, but not at alkaline, pH in strains of E. coli lacking alkaline phosphatase (U-7 and repressed K-37). Fixation in Formalin or the use of calcium as a capture reagent seemed to interfere with periplasmic staining in cells prepared for electron microscopy. Formalin fixation had little effect on biochemical assays of the phosphatase activity of intact cells in suspension, but partially reduced the activity evident in sonically treated extracts or in suspensions of dispersed cryostat sections. Glutaraldehyde treatment impaired enzyme activity more drastically. PMID- 4319726 TI - Studies on DDD mouse with special reference to mammary gland tumors. PMID- 4319725 TI - Biochemical and cytochemical evidence for the polar concentration of periplasmic enzymes in a "minicell" strain of Escherichia coli. AB - A number of "surface" enzymes of Escherichia coli (i.e., among those selectively released by osmotic shock) all displayed higher specific activities in extracts of minicells than in extracts of typical rod forms; these enzymes included alkaline phosphatase, cyclic phosphodiesterase, acid hexose monophosphatase, 5' nucleotidase, and ribonuclease I. In addition, alkaline phosphatase, cyclic phosphodiesterase, and acid hexose monophosphatase were cytochemically localized to regions of minicell periplasm that resembled reactive polar enlargements of the periplasm in rod forms. In contrast, a number of "internal" cytoplasmic enzymes (inorganic pyrophosphatase, beta-galactosidase, glutamine synthetase, polynucleotide phosphorylase, and ribonuclease II) showed elevated or similar specific activities in extracts of rod forms versus extracts of minicells. A specific heat-labile inhibitor for 5'-nucleotidase, known to occur in the cytoplasm, also showed no enrichment in minicells. These findings indicate that the "surface" enzymes are segregated in vivo into the terminal minicell buds, possibly because these enzymes are concentrated in the polar enlargements of the periplasm in typical rod forms. PMID- 4319728 TI - Intestinal resistance in the experimental enteric infection of mice with a mouse adenovirus. I. Growth of the virus and appearance of a neutralizing substance in the intestinal tract. PMID- 4319727 TI - Ibaraki virus, an agent of epizootic disease of cattle resembling bluetongue. IV. Physicochemical and serological properties of the virus. PMID- 4319729 TI - Aluminum-marker of wild type 1 poliovirus strains. PMID- 4319730 TI - Intracellular site of RNA replication of vesicular stomatitis virus as revealed by radioautography. PMID- 4319731 TI - [Microcirculatory activity in rats during treatment with various vasoactive substances]. PMID- 4319732 TI - Clinico-pathological conference. Pulmonary lesions and erythrocytosis. PMID- 4319733 TI - [EB virus infections]. PMID- 4319734 TI - [Cytomegalovirus infections]. PMID- 4319735 TI - [Clinical virology of rhinovirus]. PMID- 4319736 TI - [Corona virus]. PMID- 4319737 TI - [Japanese encephalitis vaccine]. PMID- 4319738 TI - [Radioisotope scanning of the liver and spleen in cases of schistosomiasis japonica]. PMID- 4319739 TI - [Surgical case of primary hepatoma with postoperative improvement of dysproteinemia]. PMID- 4319740 TI - Neurophysiologists honored (Ulf von Euler, Julius Axelrod, Bernard Katz). PMID- 4319741 TI - Decreased host cell reactivation of irradiated SV40 virus in xeroderma pigmentosum. PMID- 4319742 TI - Toxicity of poly I: poly C for rabbit eyes. PMID- 4319744 TI - Retrogenetic expression: the reappearance of embryonal antigens in cancer cells. PMID- 4319743 TI - Collagenolytic activity of sarcoma tissues in culture. PMID- 4319745 TI - Pelvic arteriography after chemotherapy of malignant trophoblastic disease. A case for caution. PMID- 4319746 TI - [Meconium peritonitis: a spontaneous cure]. PMID- 4319747 TI - [Glomus tumor in the pylorus]. PMID- 4319748 TI - The renin-angiotensin system in clinical medicine. PMID- 4319749 TI - Bullous pemphigoid. Is it an immunologic disease? PMID- 4319751 TI - Case presented by Don E. Suter, MD. PMID- 4319750 TI - Ectopic adrenocorticotropic hormone syndrome associated with metastatic skin tumors and Cushing's syndrome. PMID- 4319752 TI - Phosphorylation coupled to electron transfer in aqueous solutions. PMID- 4319753 TI - Active site of hemerythrin. Iron electronic states and the binding of oxygen. PMID- 4319755 TI - Adducts of diphosphopyridine nucleotide and carbonyl compounds. PMID- 4319754 TI - A comparative study of glycoproteins from the surface of control and Rous sarcoma virus transformed hamster cells. PMID- 4319756 TI - [Importance of cerebral scintiscanning in neurosurgical diagnosis]. PMID- 4319757 TI - Absence of alkaline phosphatase in rat thymic lymphoma induced by murine leukemia virus. PMID- 4319758 TI - Control of multiplication of uninfected mouse embryo fibroblasts and mouse embryo fibroblasts converted by infection with murine sarcoma virus (Harvey). PMID- 4319759 TI - Enzymatic and spectral analysis of cytochrome oxidase in adult and fetal rat liver and Morris hepatoma 3924A. PMID- 4319760 TI - Comparative studies on the kinetics of the neoplastic competence in mice. PMID- 4319761 TI - The significance of perinatal age periods and the dose of urethan on the tumor profile in the MRC rat. PMID- 4319762 TI - [Effect of acute oxygen starvation on the content and metabolic rate of mono-, di and triphosphoinositides in the rat brain]. PMID- 4319763 TI - [Participation of N. VPL of the thalamus in the distribution of the afferent flow to the projection fields of the cat cerebral cortex]. PMID- 4319764 TI - [Sensitivity of small intestine interoceptors to lactic acid. An attempt to correlate the character of afferent impulses with the fine structure (determined by electron microscopy) of intestinal nerves]. PMID- 4319765 TI - [Effect of light on the paramagnetic centers of gamma-irradiated DNA]. PMID- 4319766 TI - [Application of the method of magnetophotoselection in the study of the EPR of the triplet state of porphyrins]. PMID- 4319767 TI - [Diagnosis of para-influenza-3-virus infections of cattle]. PMID- 4319768 TI - [Ultra-structure of eosinophilic granulocytes in mast-cell tumors of dogs]. PMID- 4319769 TI - Citrus juice characterization. Identification and estimation of the major phospholipids. PMID- 4319770 TI - The in vivo effect of gossypol on cytochrome oxidase, succinoxidase, and succinic dehydrogenase in animal tissues. PMID- 4319771 TI - The intracytoplasmic multiplication of Yaba virus in cells as studied by means of high-resolution autoradiography. PMID- 4319772 TI - [Study of muscle relaxants using evoked electromyography. 1. Basic factors and the recovery curve of M-response]. PMID- 4319773 TI - [Paravaccinia infections in man and animal and their relationships]. PMID- 4319774 TI - [Quantitative immunoglobulin determination during long-term cytostatic therapy]. PMID- 4319775 TI - [Roentgen diagnosis of skeletal age]. PMID- 4319776 TI - Pertussis syndrome. PMID- 4319777 TI - Pertussis syndrome. PMID- 4319778 TI - [The pleomorphic adenoma]. PMID- 4319779 TI - [Clinico-morphological studies on adenovirus infection of the eye]. PMID- 4319780 TI - [Immunofluorescent and cytological study of conjunctival scrapings in patients with herpetic disease of the eyes]. PMID- 4319781 TI - [Chemical disinfection of some objects in epidemic keratoconjunctivitis]. PMID- 4319783 TI - Analysis of a functional change in membrane in the process of cell transformation by Rous sarcoma virus; alteration in the characteristics of sugar transport. PMID- 4319782 TI - Glycoprotein components of avian and murine RNA tumor viruses. PMID- 4319784 TI - Genetic analysis of simian virus 40. I. Description of microtitration and replica plating techniques for virus. PMID- 4319785 TI - [Thecoma in polycystic ovaries]. PMID- 4319786 TI - Comparative study of oral lesions associated with stachybotryotoxicosis and fowl pox. I. Clinical symptoms and gross lesions. PMID- 4319787 TI - Comparative study of oral lesions associated with stachybotryotoxicosis and fowl pox. PMID- 4319788 TI - Electrochemical studies of the redox behavior of alpha-tocopherylquinone and a related model quinone. PMID- 4319789 TI - Threonine metabolism in a strain of Bacillus subtilis: enzymic oxidation of the intermediate DL-lactaldehyde. PMID- 4319790 TI - Calcium, manganese and hepatic gluconeogenesis. PMID- 4319791 TI - [Evaluation of adrenocortical efficiency in children]. PMID- 4319792 TI - [Urine excretion of 17-hydroxycorticosteroids in premature infants]. PMID- 4319793 TI - Review of endocrinology. PMID- 4319794 TI - Spirometric measurements in an Egyptian portland cement factory. PMID- 4319795 TI - Study of pulmonary involvement in Schistosoma mansoni infection in mice utilising single and repeated infection as well as single and repeated therapy. PMID- 4319796 TI - Reticulohistiocytoma cutis. PMID- 4319797 TI - [Serotype and antibiotic sensitivity of Pseudomonas aeruginosa isolated from clinical materials]. PMID- 4319798 TI - [Seasonal changes in hemagglutination inhibition substance of Japanese encephalitis virus in Rana nigromaculata nigromaculata]. PMID- 4319799 TI - [Virus-specific RNA in polysome of SV-40 tumor cells]. PMID- 4319800 TI - Galactose toxicity and alterations in brain metabolism in the chick. PMID- 4319801 TI - [Flexion spasms in infants]. PMID- 4319802 TI - [Sleep]. PMID- 4319803 TI - The influence of primary hepatoma on porphyrin metabolism. PMID- 4319804 TI - [Echocardiographic studies on patients with surgically treated mitral valve stenosis]. PMID- 4319805 TI - [Problems of a physiologic vitamin D depots. 3. Vitamin D activity in the blood of calves and milk cow]. PMID- 4319806 TI - [Effects of D-vitamins and their importance in animal nutrition]. PMID- 4319808 TI - The mast cells of Gallus domesticus. I. Distribution and ultrastructure. PMID- 4319807 TI - [The effect of the depth of furrow on soil life. I. The effect of the deepening of the mould on soil life of pre-loamy and loamy sand soils]. PMID- 4319809 TI - [Panel discussion: the role of the autonomous nervous system and the adenyl cyclase-cyclic amp system in insulin release]. PMID- 4319811 TI - [Cyclic AMP and the regulation of lipolysis in human adipose tissue incubated in vitro]. PMID- 4319810 TI - [Insulin release from fetal and newborn rat pancreas in vitro: role of the adenyl cyclase system]. PMID- 4319812 TI - [Studies of insulin secretion: radioimmunoassay of cyclic nucleotides and the role of cyclic amp]. PMID- 4319813 TI - Infection of the newborn with herpesvirus hominis. PMID- 4319814 TI - Possible mechanisms for maintaining immunity to varicella-zoster virus. Clinical observations. PMID- 4319815 TI - Automated determination of glycerol in plasma. PMID- 4319816 TI - Separations of isomeric polyols. PMID- 4319817 TI - A new rapid electrophoretic method for determination of deoxyribonucleic acid base composition. PMID- 4319819 TI - [Survival in synovialoma]. PMID- 4319818 TI - [Differential diagnosis and therapy of synovial neoformations]. PMID- 4319820 TI - [Rare soft tissue tumors of the foot]. PMID- 4319821 TI - [Therapy and prognosis of benign and malignant bone tumors]. PMID- 4319822 TI - [Classification of the foot-and-mouth disease virus strain responsible for the 1967 English epidemic]. PMID- 4319823 TI - Activation of monkey spermatozoal adenyl cyclase by thyroxine and triiodothyronine. PMID- 4319824 TI - Formation of the N5-methyltetrahydrofolate-homocysteine methyltransferase holoenzyme from apoenzyme and adenosyl-B 12. PMID- 4319825 TI - Phosphorylation coupled to oxidation of thiol groups (GSH) by cytochrome c with disulfide (GSSG) as an essential catalyst. I. Demonstration of ADP formation from AMP and HPO4 2-. PMID- 4319826 TI - Structure-function studies on glyceraldehyde-3-phosphate dehydrogenase. 3. Dependency of proteolysis on NAD+ concentration. PMID- 4319827 TI - LL-diaminopimelic acid containing peptidoglycans in walls of Streptomyces sp. and of Clostridium perfringens (type A). PMID- 4319828 TI - Molecular weights, association, and frictional resistance of bovine liver glutamate dehydrogenase at low concentrations. Equilibrium and velocity sedimentation, light-scattering studies, and settling experiments with macroscopic models of the enzyme oligomer. PMID- 4319829 TI - [Quantitative determination of microdoses of angiotensin by evaluation of the changes of vascular resistance in the hind leg of the rabbit]. PMID- 4319830 TI - [Hepatoprotective activity in the rat of 2,4-monofurfurylidene-tetra-O-methyl sorbitol (MSF). 8. Influence on the variation of hepatic glucose-6-phosphatase activity induced by CCl4]. PMID- 4319831 TI - [Structure of blood group substances. Degradation of the (A + H) blood group substance by the action of an enzyme preparation of Clostridium perfringens]. PMID- 4319832 TI - [Virological observations on poliomyelitis cases occurring in Western Sicily in 1966-1968]. PMID- 4319833 TI - Effects of general anesthesia on autoregulation of cerebral blood flow in man. PMID- 4319834 TI - Asymmetric template function of microbial deoxyribonucleic acids: transcription of ribosomal and soluble ribonucleic acids. AB - In Bacillus subtilis and Escherichia coli, 16 and 23S ribosomal ribonucleic acid (rRNA) hybridize exclusively with the heavy (H) strand of methylated albuminkieselguhr (MAK)-fractionated complementary deoxyribonucleic acid (DNA) strands. All the soluble RNA (4S RNA) in B. subtilis and 66 to 75% of the 4S RNA in E. coli also hybridize with the H strand. Interspecific hybridization shows that E. coli 23S rRNA also binds selectively to the DNA H strand of Salmonella typhimurium. The hybridization peak for all three cellular RNA components is specifically located in the late-eluting region of the absorbance profile of the DNA H strand. The early-eluting region of the light (L) strand preferentially inhibits the hybridization between the peak region of the H strand and 23S rRNA. These regions are considered to represent the transcribing sequences and their complements for 23S rRNA in the separated H and L strands of DNA, respectively. PMID- 4319836 TI - Cyclic 3',5'-adenosine monophosphate and N-acetylglucosamine-6-phosphate as regulatory signals in catabolite repression of the lac operon in Escherichia coli. AB - When an Escherichia coli mutant lacking the enzyme N-acetyl-glucosamine-6 phosphate (AcGN6P) deacetylase is grown in a succinate-mineral salts medium and exposed to an exogenous source of N-acetylglucosamine, approximately 20 to 30 pmoles of AcGN6P per mug of cell dry weight will accumulate in these cells. This accumulation occurs within 2 to 4 min after the addition of N-acetylglucosamine and is coincident with the production of a severe permanent catabolite repression of beta-galactosidase synthesis. This repression does not occur if adenosine 3',5'-cyclic phosphate (cyclic AMP) is added to the cells before AcGN6P accumulates. An immediate derepression occurs when cyclic AMP is added to cells that have already accumulated a large AcGN6P pool. These findings are consistent with the view that low-molecular-weight carbohydrate metabolites and cyclic AMP play key roles in the catabolite repression phenomenon, and that metabolites such as AcGN6P may participate in the represion mechanism by influencing either the formation or degradation of cyclic AMP in E. coli. PMID- 4319835 TI - Inhibition of vitamin K2 and carotenoid synthesis in Staphylococcus aureus by diphenylamine. AB - Diphenylamine at concentrations which did not effect the growth rate inhibited the synthesis of vitamin K(2) in both anaerobic and aerobic cultures by about 50%. At this concentration, diphenylamine inhibited the synthesis of the cyclic carotenoids delta-carotene and the rubixanthins 25 to 35% anaerobically and 60 to 90% aerobically. The inhibition of synthesis of cyclic carotenoids and vitamin K(2) by diphenylamine had no detectable effect on the formation of the membrane bound electron transport system. PMID- 4319839 TI - The separation of nucleic acids on basic polyamino acid-kieselguhr columns. PMID- 4319838 TI - The identification of polymyxin B sulphate. PMID- 4319837 TI - Cytochrome content of two pseudomonads containing mixed-function oxidase systems. AB - The cytochrome and nonheme iron protein content of two pseudomonads, Pseudomonas oleovorans and P. putida, containing mixed function oxidase systems was examined. The mixed function oxidase system of P. oleovorans and P. putida had previously been shown to be present in cells which had been grown on hexane and camphor, respectively, as energy source. The content of protoheme was found to increase significantly when the organisms were grown on the substrates for mixed function oxidation. The nonheme iron protein content increased significantly in the case of P. putida and was constant in P. oleovorans. The cytochrome c content was essentially constant in both pseudomonads. The content of cytochrome P-450 in P. putida increased from an immeasurably low amount to 0.15 nmoles per mg (dry weight). The content of cytochrome o in P. oleovorans increased by a factor of 4.5. P. oleovorans was not found to contain detectable quantities of cytochrome P 450 either in the presence or absence of the mixed function oxidase system. PMID- 4319840 TI - Thin-layer chromatography of cyclic adenosine 3',5'-monophosphate on tetraborate impregnanted silica gel layers. PMID- 4319841 TI - The Paris fashions. PMID- 4319842 TI - Light inactivation of focus formation by chicken embryo fibroblasts infected with avian sarcoma virus in the presence of 5-bromodeoxyuridine. PMID- 4319844 TI - Mode of action of the anthelminthic thiabendazole in Haemonchus contortus. PMID- 4319843 TI - Tissue-specific factor required for the translation of a mammalian viral RNA. PMID- 4319845 TI - Dibutyryl cyclic AMP, vitamin D, and calcium absorption. PMID- 4319846 TI - [Diagnosis and surgical treatment of hypoglycemic islet cell adenoma]. PMID- 4319847 TI - [Pyocyanic bacilli infections and their treatment. 33 cases]. PMID- 4319848 TI - [Diagnosis and differential diagnosis of chondrocalcinosis]. PMID- 4319849 TI - Pineal function and oviposition in Japanese quail: superior cervical ganglionectomy and photoperiod. AB - Bilateral ablation of the superior cervical ganglia appears to deprive the pineal body of sympathetic innervation. Although this procedure presumably interrupts the neural circuit for transmission of optic information to the pineal, oviposition rates of ganglionectomized females exposed to stimulatory (15-hour) or to nonstimulatory (4-hour) daily photoperiods do not differ from those of the controls. PMID- 4319850 TI - Development, structure, and function of the retinal pigmented epithelium. PMID- 4319851 TI - Spinal cord afferents: functional organization and inhibitory control. PMID- 4319852 TI - Convergence of excitatory and inhibitory action on interneurones in the spinal cord. PMID- 4319853 TI - Excitatory and inhibitory processes. PMID- 4319854 TI - The organization of subpopulations in the abdominal ganglion of Aplysia. PMID- 4319855 TI - Alterations of platelet aggregation in the Chandler tube. II. Electron microscopic observations. PMID- 4319856 TI - Evaluation of non-lactose-fermenting members of the Klebsiella-Enterobacter Serratia division. II. Antibiotic susceptibility. PMID- 4319857 TI - Ultrastructure of oligodendroglioma of the spinal cord. PMID- 4319858 TI - [Adenocarcinoma of the cervix uteri and cancer of the residual stump after subtotal hysterectomy, as special problems of gynecologic radiotherapy]. PMID- 4319860 TI - Platelet aggregation by Herpes simplex antigen-antibody complexes. PMID- 4319859 TI - Some properties of the soluble (S) antigen of cultured lymphoblastoid cell lines. PMID- 4319861 TI - [Studies on the heterogeneity of herpes simplex virus by means of immunodiffusion]. PMID- 4319862 TI - Blocking of interferon action by a component of normal serum. PMID- 4319863 TI - Immunogenicity of oncolysates obtained from Ehrlich ascites tumors infected with vesicular stomatitis virus. PMID- 4319864 TI - Clostridia isolated from human mouths. PMID- 4319865 TI - Pyrophosphate and hexametaphosphate effects in in vitro calculus formation. PMID- 4319866 TI - [The effect of radiation on the mechanism of excitatory transmission in the ganglia of the autonomic nervous system]. PMID- 4319867 TI - [The effect of corazole, trimetin and diphenin on the postsynaptic potentials of motor neurons upon suprasegmental stimulation]. PMID- 4319868 TI - [The effect of 2-methylnaphthoquinone on different elements of the frog neuromuscular preparation]. PMID- 4319869 TI - [Giant cells in the cortex of the developing adrenal glands of white rats and the effect of ACTH on them]. PMID- 4319870 TI - [The mechanism of the disruption of spinal cord neuron electrical activity in experimental botulism]. PMID- 4319871 TI - [Changes in the frequency of the miniature potentials of the motor end plate following short-term tetanic stimulation of a motor nerve]. PMID- 4319873 TI - [Clinical and radiographic picture of patients with a 5-year survival following resection for lung cancer]. PMID- 4319872 TI - [Inhibiting and facilitating influences from the medulla oblongata in tetanus intoxication]. PMID- 4319874 TI - [The mecahnism of disruption of the primary phase of gastric secretion in hypophysectomized dogs]. PMID- 4319875 TI - Influence of auxins on growth of Claviceps purpurea (Fries) Tulasne in saprophytic cultures. PMID- 4319876 TI - Steroid derivatives. LXXI. The microbial dehydrogenation of 17beta-hydroxy 17alpha-methyl-5alpha-androstan-3-one. PMID- 4319877 TI - Cutaneous porphyria due to a malignant primary hepatoma. PMID- 4319879 TI - [The behavior of Cryptococcus neoformans in the soil. II. Long term studies of the survival time of Cryptococcus neoformans in artificially infected sand and garden soil under external environmental conditions]. PMID- 4319878 TI - Experimental left ventricular akinesis: results of excision. PMID- 4319880 TI - [Increased Na turnover in rats with renal hypertension]. PMID- 4319881 TI - Interferon and cell division. I. Inhibition of the multiplication of mouse leukemia L 1210 cells in vitro by interferon preparations. AB - Mouse interferon preparations inhibited the multiplication of mouse leukemia L 1210 cells in stationary suspension cultures. The degree of inhibition was found to correlate with the antiviral titer of the interferon preparations. The factor(s) responsible for inhibition of L 1210 cell multiplication could not be dissociated from interferon by standard physicochemical means. PMID- 4319882 TI - Specific inhibition of tumor cell DNA synthesis in vitro by lymphocytes from peritoneal exudate of immunized syngeneic guinea pigs. AB - Tumor immunity to a transplantable diethylnitrosamine-induced hepatoma in inbred guinea pigs has been found to be immunologically specific and cell mediated. We have investigated this cellular immunity using a quantitative, reproducible, and simple assay based on the ability of leucocytes to inhibit the incorporation of tritiated thymidine (TdR(3)H) by tumor cells. Tumor cell suspensions were obtained from the ascites form or tissue culture monolayers of the hepatoma. Cells from the peritoneal exudate of immunized guinea pigs inhibited tritiated thymidine uptake by tumor target cells to a significantly greater degree than cells from the peritoneal exudate of unimmunized animals. Immune lymph node, peripheral blood, and spleen leucocytes were not inhibitory. The assay was sufficiently sensitive to detect relatively weak tumor immunity. The in vitro inhibition was correlated directly with the presence of delayed hypersensitivity and/or inhibition of tumor cell growth in local passive transfer studies. Irradiation of peritoneal exudate cells (3000 R) blocked their inhibitory effects on tumor cells. Fractionation of the peritoneal exudate cells by centrifugation in zones of bovine serum albumin of different density also revealed the lymphocytes to be responsible for the specific inhibitory effects whereas macrophages inhibited in an immunologically nonspecific fashion. PMID- 4319883 TI - Spin-state changes in cytochrome P-450cam on binding of specific substrates. AB - The electron paramagnetic resonance signals of the soluble P-450 cytochrome from Pseudomonas putida were observed at temperatures from 4.2 to 80 degrees K. As isolated, P-450 has a signal typical of a low spin ferric-heme compound with sulfur as one of the axial ligands (g = 2.45, 2.26, 1.91(5)). We also detected a minor signal typical of high spin ferric heme (g = 8, 4, 1.8) equivalent to less than 7% of the heme at temperatures below 20 degrees K. On titration with the substrate, (+)-camphor, the low spin signal decreased and the high spin signal increased, maximally representing about 60% of the heme. For reasons not thus far understood, 40% of the heme is not converted to high spin by either (+) or (-) camphor. The high spin signal has a rhombic character which is stronger than any previously observed with a heme compound (E = 0.33 cm(-1); D = 3.8 cm(-1); E/D = 0.087). We conclude that P-450(cam) as isolated is equal to or more than 95% in a low spin form probably having sulfur as one of the axial ligands. The binding of substrate displaces this ligand sufficiently to allow for conversion from a low to a high spin form. PMID- 4319884 TI - Murine sarcoma virus transformation of BALB-3T3 cells: lack of dependence on murine leukemia virus. AB - Murine sarcoma virus induces foci of morphologically altered cells in BALB/3T3 cultures. Focus formation in mouse cells has been thought to require the presence of a helper, murine leukemia virus, which is present in murine sarcoma virus stocks but by itself does not induce any morphological transformation of mouse cells. The present studies show that early after infection, the titration pattern for murine sarcoma virus in BALB/3T3 cells is "two-hit" since only foci produced by virus spread can be detected. Such foci require the presence of both viruses in the initially infected cell. By seven days the titration pattern is "one-hit" under culture conditions which allow the growth and detection of small foci of transformed cells induced by murine sarcoma virus alone. The "two-hit" titration pattern results from the inability to detect these foci. We conclude that murine sarcoma virus is able to transform mouse cells without requiring murine leukemia virus. PMID- 4319885 TI - Promitochondria of anaerobically grown yeast. IV. Conversion into respiring mitochondria. AB - Promitochondria of anaerobically grown Saccharomyces cerevisiae were selectively labeled in vivo by incubating the cells with [(3)H]leucine and cycloheximide. When the labeled cells were washed free of cycloheximide and adapted to oxygen in the presence of unlabeled leucine, the respiring mitochondria formed during adaptation proved to be radioactive. In contrast, only insignificant label was found in iso-1-cytochrome c which is synthesized de novo during adaptation. Respiratory adaptation of anaerobically grown yeast thus involves differentiation of promitochondrial organelles. PMID- 4319886 TI - Food poisoning occurrences in New York City, 1969. PMID- 4319887 TI - Tarsal-tunnel syndrome. PMID- 4319888 TI - Antagonism by calcium of the inhibitory action of prostaglandin E2 on sympathetic neurotransmission in the cat spleen. PMID- 4319889 TI - [The influence of O-(beta-hydroxyethyl)-rutoside on the experimental edema of the brain]. PMID- 4319890 TI - Interaction of antimicrobial therapy and intestinal flora. PMID- 4319892 TI - Energy metabolism in anaerobes. PMID- 4319891 TI - Effect of antibiotics on bacterial ecology in animals. PMID- 4319894 TI - [Transplantability of skin tumors of the Syrian hamster induced by the hamster Papovavirus]. PMID- 4319893 TI - Vascular reactivity of rats altered by cadmium and a zinc chelate. PMID- 4319896 TI - [Physiology of the hypophysis in the menopause: mechanism of regulation]. PMID- 4319897 TI - [Apropos of a series of 20 adenomas of Langerhans islets]. PMID- 4319895 TI - [Morphological and histochemical enzyme studies in experimental PNS-tumors of rats]. PMID- 4319898 TI - Synthesis of alpha-phosphotidic acids. PMID- 4319899 TI - Nuclear magnetic resonance and ultraviolet studies of the effect of p2H on reduced nicotinamide-adenine dinucleotide. PMID- 4319900 TI - Phosphonolipids. 23. Synthesis of phosphonic acid analogues of L-alpha-(N methyl)cephalins. PMID- 4319901 TI - Phosphonolipids. XXIV. Phosphonolipid metabolites. Synthesis of L-alpha-glyceryl (N-methyl-2-aminoethyl)phosphonate. PMID- 4319902 TI - Establishment of a transplantable ascites variant of a rat hepatoma induced by 3' methyl-4-dimethylaminoazobenzene. PMID- 4319903 TI - The metabolism of hepatoma cell strains in an improved filter well apparatus. PMID- 4319904 TI - Accelerated response of hepatic DNA synthesis to partial hepatectomy in rats pretreated with growth hormone or surgical stress. PMID- 4319905 TI - Mechanism of the growth inhibition potentiation arising from combination of 6 mercaptopurine with 6-(methylmercapto)purine ribonucleoside. PMID- 4319906 TI - Effect of crystalline abrin on the biosynthesis of protein, RNA, and DNA in experimental tumors. PMID- 4319907 TI - Cellular immunity to Rous sarcoma in tumor-bearing chickens. PMID- 4319908 TI - [Hypothesis on the mechanism of formation of temporary connections]. PMID- 4319909 TI - [Inhibition of the formation of mature poliovirus particles under hypotonic conditions]. PMID- 4319910 TI - [A new method of treating radiation-induced brachial plexus pareses, after operation for carcinoma of the breast]. PMID- 4319911 TI - Mechanism of pigment-cell toxicity produced by hydroxyanisole. PMID- 4319912 TI - The histochemistry of biliary mucins and the changes caused by infestation with Clonorchis sinensis. PMID- 4319913 TI - The effect of vaso-active substances on rat mesenteric blood vessels. PMID- 4319914 TI - [Experimental conditions for inducing in the laboratory chronic interstitial nephritis in laboratory animals by means of natural silicates added to drinking water]. PMID- 4319915 TI - [Experience with the new short tests adrenal cortex function]. PMID- 4319917 TI - [Cylindroid adenoma of the parotid gland]. PMID- 4319918 TI - [Poly-micro-adenomatosis in Cushing's syndrome]. PMID- 4319916 TI - Molybdate metabolism in Aspergillus nidulans. II. Mutations affecting phosphatase activity or galactose utilization. PMID- 4319919 TI - Hormonal effects on cyclic AMP in a renal-cell suspension system. PMID- 4319920 TI - Long-term in vitro cultivation of Rauscher Leukemia virus in rat embryo cells. PMID- 4319921 TI - Serologic and infectivity studies of canine SV-5 virus. PMID- 4319922 TI - Fowlpox virus: interferon production and sensitivity. PMID- 4319923 TI - Drug-induced changes in brain dopamine and their relation to parkinsonism. PMID- 4319924 TI - Physiological roles of the prostaglandins. PMID- 4319925 TI - Inflammation and herpes simplex virus: release of a chemotaxis-generating factor from infected cells. AB - Infection of primary rabbit kidney cells with herpes simplex virus leads to the release of a cell factor or factors that upon incubation with serum results in the cleavage of the fifth component, C5, of complement. The product of this cleavage, C5a, is chemotactic for polymorphonuclear leukocytes and could be responsible for the accumulation of these cells at the site of herpetic lesions. PMID- 4319927 TI - [Intracytoplasmic inclusions in the liver in myoclonus epilepsy]. PMID- 4319929 TI - [Synaptic processes in lumbar motoneurons induced by stimulation of the sensorimotor area of the cerebral cortex]. PMID- 4319926 TI - [Biochemistry of some parasitic helminths and protozoa and the mode of action of some antiparasitic drugs]. PMID- 4319928 TI - [Fluorescence optical demonstration of amyloid by means of thioflavin S]. PMID- 4319930 TI - [Risks in hemotherapy: viral hepatitis]. PMID- 4319931 TI - Management of the intraoral benign pleomorphic adenoma. PMID- 4319933 TI - Anemia in uremia. PMID- 4319932 TI - Uremic toxins and mineral metabolism. Potential sites of interaction. PMID- 4319934 TI - Effect of chronic uremia on collagen metabolism in skin and bone. PMID- 4319935 TI - Bone formation and resorption in tissue culture. Effect of agents implicated in renal osteodystrophy. PMID- 4319936 TI - The nature of vitamin D resistance in experimental uremia. PMID- 4319937 TI - Treatment of renal osteodystrophy with 25-hydroxycholecalciferol. PMID- 4319938 TI - Immunopathology of oral leukoplakia. AB - The lymphocyte transformation test was performed with autologous saline homogenates of leukoplakia. A negative correlation was established (P<0.05) between the (14)C thymidine uptake of lymphocytes in vitro and the non pyroninophilic mononuclear cell infiltration in biopsies. A depression of lymphocyte transformation was revealed in patients with carcinoma or carcinoma in situ and some with epithelial atypia, as compared with those showing only hyperkeratosis and to a less extent those with acanthosis. A corresponding depression was not found when lymphocytes were stimulated with phytohaemagglutinin, Candida albicans or Herpes simplex antigens. The Pyroninophilic cell count was raised in biopsies with carcinoma or carcinoma in situ and in some with epithelial atypia or acanthosis. These result suggest that in leukoplakia the carcinomatous transformation may be associated with some immunological changes. PMID- 4319939 TI - Synovial sarcoma of the abdominal wall. AB - A case report is presented of a synovial sarcoma arising in the abdominal wall. This is the seventh such case to be reported. A brief review of the clinical and pathological features of synovial sarcoma is made.Pre-operative diagnosis of an abdominal wall synovial sarcoma is virtually impossible, but should be considered when a soft tissue swelling is found to show amorphous stippled calcification on X-ray. PMID- 4319940 TI - Tumorigenic effect of thioacetamide in Swiss strain mice. AB - Male and female Swiss strain mice were put on a 0.03% thioacetamide diet at the age of 2 months. Control mice were kept on a stock diet. Control and treated mice were killed at the ages of 6, 9, 13 and 17 months. Progressive morphological, histological and biochemical alterations in the liver and tumour tissue of the treated mice were studied. In the 17-month-old group, 12 out of 13 treated mice developed hepatomas. PMID- 4319942 TI - Induction of papillomas in rabbits with nucleic acid extracts from Vx7 carcinomas. AB - Nucleic acid extracts from transplantable carcinomas Vx7 and Vx2, long maintained in domestic rabbits, were assayed for their ability to produce papillomas in animals of this kind. The Vx7 had been serially transferred 111 times when this was attempted and Vx2 was in its 203rd generation. The nucleic acid extracts from the Vx7 carcinomas consistently yielded papillomas whereas those from Vx2 completely failed to do so. The tumorigenicity of the Vx7 extracts was slight and regression of the induced papillomas often took place, as happens not infrequently to the growths caused by nucleic acid extracts obtained directly from papillomas. Malignant conversion, a common event in tumors induced by Shope papilloma virus, was also observed to occur among papillomas which were induced by the nucleic acid extracts from Vx7 carcinomas, and which kept persisting over a year on the skin of experimental animals. PMID- 4319941 TI - Studies on progressive metabolic alterations in thioacetamide induced hepatocarcinogenesis. AB - Sequential studies on levels of glycogen and lactic acid as well as activities of glucose-6-phosphatase, fructose-1, 6-diphosphatase aldolase, aspartic and ornithine transcarbamylase, arginase and xanthine oxidase were carried out in liver and tumour tissue of mice fed with 0.03% thioacetamide in normal stock diet. It was observed that significant decrease in glycogen content and activities of gluconeogenic enzymes was apparent at the age of 4 months, i.e. 2 months after thioacetamide treatment. Alterations in the other parameters studied were observed later, i.e. at the age of 9 months. Maximum changes were observed in the hepatomas, i.e. at the age of 17 months. PMID- 4319943 TI - Mammary tumour development in BR6 mice: hormonal stimulation. AB - BR6 female mice treated with a mixture of hormones, developed mammary tumours earlier than untreated virgin animals. Implantation of ectopic pituitaries also increased tumour incidence and reduced the age at which tumours first appeared. This effect was obtained even in the absence of ovaries. Neither hormone treatment nor ectopic pituitaries succeeded in producing tumours as early as they appear in breeding females. PMID- 4319944 TI - Carcinogenicity of a single administration of N-nitrosomethylurea: a comparison between newborn and 5-week-old mice and rats. AB - N-Nitrosomethylurea (NMUrea) was given as a single intraperitoneal injection either to newborn or to 5-week-old (C57BL * C3Hf)F(1) mice and Wistar rats. Newborn mice were more susceptible than 5-week-old mice to the development of lymphosarcomas, lung adenomas and hepatomas, whereas newborn rats were more susceptible than their weaned counterparts to the development of renal anaplastic tumours. Other tumours occured with the same frequency in newborn and mature animals. Tumours of the forestomach in mice were more frequenty found in animals treated at 5 weeks than in those treated at birth. Since NMUrea persists for only a very short time and breaks down spontaneously it seems that the paucity of enzymes related to immaturity in newborns is not a major factor in determining the different susceptibility of newborn animals to NMUrea carcinogenicity. PMID- 4319945 TI - Histogenetic relationship between carcinoids and mucin-secreting carcinomas of colon as revealed by heterotransplantation. AB - Heterotransplantation of a human colonic neoplasm with classical morphologic characteristics of a carcinoid was sucessful in the cheek pouches of unconditioned, adult golden hamsters after a short sojourn in cell-impermeable chambers in rats. Although no mucin-secreting cells were detected in the donor carcinoid, the cheek pouch transplants exclusively exhibited mucinsecreting tumour cells of signet-ring type consistent with adenocarcinoma. This transplantable tumour, designated GW-77, has retained this appearance as well as expansive growth characteristics in xenogeneic hosts for a period of 4 years.These findings represent strong biological evidence consonant with views, based upon morphological findings, advocating a histogenetic relationship between colonic carcinoid and adenocarcinoma. It is believed that colonic adenocarcinoma has a selective advantage over carcinoid for serial propagation in an alien environment, indicating the less differentiated nature of its cellular components. Since the donor carcinoid cells failed to exhibit argentaffin reactions, these conclusions may be limited only to the nonreactive forms of carcinoid. PMID- 4319946 TI - Carcinoma of the urachus. PMID- 4319947 TI - Bell's palsy and surgery. PMID- 4319948 TI - Airborne transmission of smallpox. PMID- 4319949 TI - Response to stress. PMID- 4319951 TI - Magnesium and neuromuscular irritability in calves, with particular reference to hypomagnesaemic tetany. PMID- 4319952 TI - An additional role for insulin in the control of fatty acid synthesis independent of glucose transport. PMID- 4319953 TI - Metabolic control mechanisms in mammalian systems. XI. Pyruvate kinase modulation in the rat prostate and seminal vesicles. PMID- 4319954 TI - [Control mechanism of hormone secretion in the hypophysis-adrenal cortex system]. PMID- 4319950 TI - Cancer chemotherapy--the first twenty-five years. PMID- 4319955 TI - [Control mechanism of aldosterone secretion]. PMID- 4319957 TI - [Control mechanism of insulin secretion]. PMID- 4319956 TI - [Control mechanism of growth hormone secretion]. PMID- 4319959 TI - [Therapy and prohylaxis of the canary-pox]. PMID- 4319958 TI - [Control mechanism of glucagon secretion]. PMID- 4319961 TI - Effect of recurrent stimulation of the brain stem reticular formation on REM sleep in cats. PMID- 4319960 TI - Maintained and evoked unit activity in the mesencephalic reticular formation of the freely behaving cat. PMID- 4319962 TI - [Bordet's tracks in Mexican microbiology]. PMID- 4319963 TI - [Action of corticotropin on sulfatase-steroid of human adrenal cortex and its participation in the biosynthesis of corticosteroids]. PMID- 4319964 TI - Sacrococcygeal tumors. PMID- 4319965 TI - Acoustic neuroma: a simplified test. PMID- 4319966 TI - Relation of renal cortical gluconeogenesis, glutamate content, and production of ammonia. AB - Glutamate is an inhibitor of phosphate dependent glutaminase (PDG), and renal cortical glutamate is decreased in metabolic acidosis. It has been postulated previously that the rise in renal production of ammonia from glutamine in metabolic acidosis is due primarily to activation of cortical PDG as a consequence of the fall in glutamate. The decrease in cortical glutamate has been attributed to the increase in the capacity of cortex to convert glutamate to glucose in acidosis. In the present study, administration of ammonium chloride to rats in an amount inadequate to decrease cortical glutamate increased the capacity of cortex to produce ammonia from glutamine in vitro and increased cortical PDG. Similarly, cortex from potassium-depleted rats had an increased capacity to produce ammonia and an increase in PDG, but glutamate content was normal. The glutamate content of cortical slices incubated at pH 7.1 was decreased, and that at 7.7 was increased, compared to slices incubated at 7.4, yet ammonia production was the same at all three pH levels. These observations suggest that cortical glutamate concentration is not the major determinant of ammonia production. In potassium-depleted rats there was a 90% increase in the capacity of cortex to convert glutamate to glucose, yet cortical glutamate was not decreased. In vitro, calcium more than doubled conversion of glutamate to glucose by cortical slices without affecting the glutamate content of the slices, and theophylline suppressed conversion of glutamate to glucose yet decreased glutamate content. These observations indicate that the rate of cortical gluconeogenesis is not the sole determinant of cortical glutamate concentration. The increase in cortical gluconeogenesis in acidosis and potassium depletion probably is not the primary cause of the increase in ammonia production in these states, but the rise in gluconeogenesis may contribute importantly to the maintenance of increased ammoniagenesis by accelerating removal of the products of glutamine degradation. PMID- 4319967 TI - Human alveolar macrophages: comparison of phagocytic ability, glucose utilization, and ultrastructure in smokers and nonsmokers. AB - Phagocytic ability, glucose utilization, and ultrastructural morphology were studied in human alveolar macrophages in smokers and nonsmokers. The macrophages were obtained by bronchopulmonary lavage and the studies were carried out in vitro in the absence of smoke. Phagocytic ability was measured as the decrease in the number of viable Staphylococcus albus organisms incubated with the macrophages. Measurements of (14)CO(2) formation from glucose-U-(14)C were made in a resting state. 90-95% of the cells obtained by lavage were large mononuclear macrophages of which approximately 90% remained viable at the end of the experiment. Smokers yielded many more macrophages per lavage (mean 46.4 x 10(6) +/-7.4) compared to the nonsmokers (mean 10.2 x 10(6) +/-2.3). The decline in viable organisms was the same in each group, indicating phagocytic competence of alveolar macrophages removed from smokers. However, the mean glucose utilization for the smokers was 4.3 +/-0.2 mmumoles/10(6) cells and 1.4 +/-0.7 mmumoles/10(6) cells for the nonsmokers. This very significant difference (P < 0.0001) suggests that smokers' macrophages have a higher resting energy requirement than those of nonsmokers. Comparison of the ultrastructural morphology of the alveolar macrophages from each group reveals that the cells from smokers differ from those of nonsmokers in that they are slightly larger, and contain more golgi vesicles, endoplasmic reticulum, and residual bodies. The residual bodies in smokers' cells contain distinctive fiber-like inclusions. PMID- 4319968 TI - Perifusion of rat pancreatic tissue in vitro: substrate modification of theophylline-induced biphasic insulin release. AB - The immunoreactive insulin (IRI) release patterns produced by continuous theophylline stimulation of rat pancreas have been defined, using an in vitro perfusion system. In the presence of glucose, citrate, and pyruvate at concentrations which were nonstimulatory by themselves, continuous stimulation with theophylline produced a biphasic IRI release profile. In the absence of substrate, continuous theophylline stimulation produced only an abrupt and limited primary response. Of the substrates tested, only glucose significantly enhanced this primary response. With increasing theophylline concentrations, whether in the presence or absence of substrate, significant increases were noted in the primary response as estimated by either the maximum rate of IRI release attained or by the total amount of IRI released during this time. Similarly, the secondary responses to theophylline increased with theophylline concentration in the presence of either citrate or pyruvate. With glucose as substrate, however, increasing theophylline concentrations from 2.5 to 5, then 10 mM produced a progressive reduction in both indices of the secondary response, which was inversely related to the primary response. These findings suggest that cyclic AMP not only mediates IRI release in quantitative terms but is also implicated in the qualitative nature of the response pattern. They also indicate a possible metabolic basis for biphasic IRI release, the acute or primary response being dependent upon the basal state of the cell and the availability of endogenous energy sources, the secondary response upon the availability of exogenous substrate. PMID- 4319969 TI - Potassium balance and the control of renin secretion. AB - Plasma renin activity and renin substrate were measured in nine groups of rats which were maintained for 7 wk on diets in which the proportions of sodium and potassium were varied. Balance data indicated that the highest dietary intake of potassium employed (92 mEq K(+)/100 g food) consistently induced sodium depletion. With less consistency, the highest sodium intake employed (52 mEq Na(+)/100 g food) tended to induce potassium depletion.In accordance with previous reports, sodium deprivation induced significant increases in plasma renin activity. But the present results indicated that changes in potassium intake exerted a highly significant modulating influence on this characteristic response. The results describe an inverse relationship between potassium administration and the concurrent level of plasma renin activity. The highest serum renin levels of all occurred in the potassium-depleted animals and the usual renin response to sodium deprivation was virtually abolished in the presence of a high potassium diet. Neither the suppressing effect of K(+) administration nor the stimulating effect of K(+) depletion on plasma renin activity could be explained in terms of any predicted changes in aldosterone secretion or observed changes in sodium balance. Therefore, the effect seems to be mediated by a direct influence of potassium ions on renal renin secretion, perhaps via induced changes in sodium load to the macula densa.These studies point to an important role for potassium in the regulation of renin secretion. The results in turn raise the possibility that renin secretion per se may be importantly involved in effecting potassium conservation and potassium elimination. The means by which these interactions are finally mediated remain to be clarified. PMID- 4319970 TI - The influence of potassium administration and of potassium deprivation on plasma renin in normal and hypertensive subjects. AB - The effect of potassium administration and of dietary potassium deprivation on plasma renin activity and aldosterone excretion has been studied in 10 normal subjects and in 12 hypertensive patients maintained on a constant dietary regimen. Potassium administration reduced plasma renin activity in 18 of 28 studies of both normal and hypertensive subjects. Suppression of renin often occurred despite sodium diuresis induced by potassium administration. The renin suppression was related to induced changes in plasma potassium concentration and urinary potassium excretion. The failure of suppression of plasma renin in 10 studies could be accounted for by the smaller amounts of potassium administered to these subjects, together with a possibly overriding influence of an induced sodium diuresis. In six studies potassium deprivation invariably increased plasma renin activity even though a tendency for sodium retention often accompanied this procedure. The data indicate that both the suppression of plasma renin activity induced by potassium administration and the stimulation of renin activity which follows potassium depletion occur independently of associated changes in either aldosterone secretion or in sodium balance. However, the results do suggest that in various situations, the influence of potassium on plasma renin activity may be either amplified or preempted by changes in sodium balance. These interactions between potassium and plasma renin could be mediated by an ill-defined extrarenal pathway. But the findings are more consistent with an intrarenal action of potassium ions to modify renin release. Potassium might modify renin secretion directly by acting on the juxtaglomerular cells or by a change in its tubular reabsorption or secretion. The effects of potassium ions on renin secretion might also be mediated indirectly via an induced change in tubular sodium transport. PMID- 4319971 TI - Reduced brain glucose with normal plasma glucose in salicylate poisoning. AB - After the intraperitoneal injection into young mice of 700-800 mg/kg of salicylate, brain glucose fell to one-third or less of control values despite normal plasma glucose levels; brain lactate was nearly doubled and there were small decreases in phosphocreatine (18%) and in glycogen (17%). ATP, pyruvate, alpha-ketoglutarate, and glutamate were unchanged. In liver, glycogen was reduced 79% and lactate was five times higher than in control animals; glucose, glucose-6 phosphate, and ATP were unchanged. Since salicylate uncouples oxidative phosphorylation, it is postulated that high energy phosphate in the brain is maintained near normal levels by a compensatory increase in cerebral glycolysis. Apparently the brain glucose level falls because the rate of utilization exceeds the rate at which glucose can be supplied from the blood. Concurrent administration of glucose with salicylate elevated brain glucose concentration and was associated with striking improvement in the condition and the increased survival of the animals. These findings stress the fact that in salicylate poisoning the supply of glucose to the brain may be inadequate even when blood glucose levels are normal. PMID- 4319972 TI - Preliminary report on the detection and quantitation of opiates and certain other drugs of abuse as trimethysilyl derivatives by gas-liquid chromatography. PMID- 4319974 TI - Estimation of hydroxyproline in urine. PMID- 4319973 TI - Mechanism of excitation of Aplysia neurons by carbon dioxide. AB - The abdominal ganglion of Aplysia californica was perfused with artificial seawater equilibrated at different P(COCO2)'s and pH's for 5 min or less. 5% CO(2) dropped perfusate pH from 8.0 to 6.5 and produced depolarization and increased discharge rate in visceromotor neurons. Half the giant cells studied had a similar response, whereas the other half were hyperpolarized. Pacemaker neurons showed little, if any, response to such changes in pH or CO(2). Membrane conductance of responsive cells was always increased. The effect of CO(2) occurred even when synaptic transmission was blocked by low calcium and high magnesium, and therefore must have been a direct result of CO(2) or the concomitant fall in pH. When extracellular pH was lowered to 6.5 using HCl or H(2)SO(4) and no CO(2), the same effects were observed. Also, local application of HCl or H(2)SO(4) to the external surface of the cell soma elicited depolarization and spike discharge. When extracellular pH was held constant by continual titration, 5-50% CO(2) had no effect. Intracellular pH was probably decreased at least one pH unit under these circumstances. Thus CO(2) per se, decreased intracellular pH, and increased bicarbonate ion were without effect. It is concluded that CO(2) acts solely through a decrease in extracellular pH. PMID- 4319975 TI - [Activity of urine and blood enzymes in transplantation of a cadaveric kidney]. PMID- 4319976 TI - [Pleomorphic adenomas of the salivary gland]. PMID- 4319977 TI - [Histologic classification of bronchial carcinoma]. PMID- 4319978 TI - [Statistical contributions concerning the grading of gliomas. 3. Astrocytomas and oligodendrogliomas]. PMID- 4319981 TI - ACTH test for adrenocortical insufficiency. PMID- 4319980 TI - A convenient synthetic route to 2-deoxy-L-ribose and 2-deoxy-D-xylose. PMID- 4319979 TI - A continuous spectrophotometric method for ammonia-generating reactions. PMID- 4319982 TI - Nerve blocking agents. PMID- 4319983 TI - Comparative ultrastructural studies on three thymic lesions. PMID- 4319984 TI - Benign tumors and pseudotumors of the gallbladder. Report of 180 cases. PMID- 4319985 TI - Transients in the reactions of liver alcohol dehydrogenase. PMID- 4319986 TI - Spectrophotometric observations on the oxidation-reduction cycle of the respiratory chain-linked reduced nicotinamide-adenine dinucleotide dehydrogenase. PMID- 4319987 TI - 25,26-dihydroxycholecalciferol, a metabolite of vitamin D3 with intestinal calcium transport activity. PMID- 4319988 TI - Factors affecting lipolysis rates in rat adipose tissue. PMID- 4319989 TI - Lipid metabolism in the parasitic and free-living flatworms, Schistosoma mansoni and Dugesia dorotocephala. PMID- 4319990 TI - Phospholipid composition of membranes in the tumor cell. PMID- 4319991 TI - Isolation and characterization of a glycolipid from Treponema pallidum, Kazan 5. PMID- 4319992 TI - Effects of ascorbic acid on the side-chain cleavage of cholesterol. PMID- 4319993 TI - On the metabolic heterogeneity of rat liver phosphatidylinositol. PMID- 4319995 TI - [Change in the free radical state of plant tissues under the effect of inhibitors of free radical reactions]. PMID- 4319994 TI - [Temperature quenching of the triplet state of porphyrins. I. Effect of solvent and oxygen]. PMID- 4319996 TI - [Cerebellar influence on the reticulo-spinal neurons during locomotion]. PMID- 4319997 TI - [Electron spin resonance and nuclear gamma-resonance studies of yeasts oxidizing carbohydrates]. PMID- 4319998 TI - [The renin-angiotensin system: methodology and clinical importance]. PMID- 4320000 TI - [Contributions to the study of the physiology of wakeful and sleep states]. PMID- 4319999 TI - Functional interrelationships between the adenohypophysis, thyroid, adrenal cortex and gonads. PMID- 4320001 TI - Biosynthesis of sphingosine and dihydrosphingosine by cell-free systems from Hansenula ciferri. PMID- 4320002 TI - [Peripheral nerve dysfunction after injuries to the elbow region]. PMID- 4320003 TI - [Carpal tunnel and Gijon's tunnel syndrome]. PMID- 4320004 TI - Observations on the fine structure of the substantia nigra in the cat. PMID- 4320005 TI - Repetitive impulses generated in fast and slow pyramidal tract cells by intracellularly applied current steps. PMID- 4320006 TI - Development and persistence of immunity to Epstein-Barr virus in man. PMID- 4320007 TI - Improved lymphocyte serotyping techniques for organ matching. PMID- 4320008 TI - The Coronary Drug Project. Initial findings leading to modifications of its research protocol. PMID- 4320009 TI - Experimental studies on the combined effect of kanamycin and viomycin. PMID- 4320010 TI - Aerosol immunization of humans with inactivated parainfluenza type 2 vaccine. PMID- 4320011 TI - [Radiodiagnosis of cecal neoplasms]. PMID- 4320013 TI - [Acute respiratory syndromes caused by viruses and Rickettsia]. PMID- 4320012 TI - [Relation between the protein structure and function]. PMID- 4320014 TI - [On modern estrogen therapy]. PMID- 4320015 TI - [Radiography of the liver using ultrafluid lipiodol (preliminary note)]. PMID- 4320016 TI - Non human hepatitides as models for study of pathogenesis of human hepatitis. PMID- 4320017 TI - Lysosomes and pyroninophilia in mononuclear cells in hypertensive arterioles. Studies on the blood, arterioles and regional lymph nodes in experimental angiotensin-hypertension in rats. PMID- 4320018 TI - The secondary and tertiary inflammatory cellular reaction in arterioles damaged by acute angiotensin-hypertension in rats. PMID- 4320019 TI - The effect of alloxan on kidney cortex microsomes. PMID- 4320020 TI - Malignant melanotic progonoma. One case. PMID- 4320021 TI - Studies on the multiplication of vesicular stomatitis virus with fluorescein and ferritin conjugated antibodies. PMID- 4320022 TI - Endogenous incorporation of 32 P in Neisseria meningitidis. I. The effects of CO2 and electron flux. PMID- 4320023 TI - The control of glycogen synthesis in the liver. PMID- 4320024 TI - A cyclic 3',5'-amp-stimulated protein kinase from cardiac muscle. PMID- 4320025 TI - Regulation of the phosphorylase activating pathway in intact cardiac and skeletal muscle. PMID- 4320026 TI - Insulin-receptor interaction in isolated fat cells. PMID- 4320027 TI - Control of cutaneous collagenolysis. PMID- 4320028 TI - Anomalous distribution of glutaminase isozyme in various hepatomas. PMID- 4320029 TI - Regulation of the synthesis of serine dehydratase isozymes. PMID- 4320030 TI - [Outline of a new trend in therapy of vitreous opacity of inflammatory origin]. PMID- 4320031 TI - Induced hypertension in the treatment of the ischaemic foot. PMID- 4320032 TI - The monoamine metabolism in viral encephalitides of the mouse. I. Virological and biochemical results. PMID- 4320033 TI - induction of thymic lymphosarcoma and mammary adenocarcinomas in rats by oral administration of the antitumor agent, 4 (5)-(3,3-dimethyl-1-triazeno) imidazole 5 (4)-carboxamide. PMID- 4320034 TI - Gastrointestinal "sterilization" in the treatment of patients with acute leukemia. PMID- 4320035 TI - High plasma renin activity in an oat cell carcinoma: a renin-secreting carcinoma? PMID- 4320036 TI - Aldosterone secretion and plasma renin activity in chromophobe adenoma: effect of acth. PMID- 4320037 TI - Angiography in juvenile nasopharyngeal haemangiofibroma. PMID- 4320038 TI - [Late lesions of the liver following hepatitis infectiosa. Catamnestic and clinical studies]. PMID- 4320039 TI - [The normal small bowel mucosa and its changes in endemic sprue. Morphological and histochemical findings]. PMID- 4320040 TI - High incidence of pulmonary tumors in dd mice by a single injection of cycasin. PMID- 4320041 TI - Response of adult mastomys (Praomys natalensis) to subcutaneous injection of N nitrosodimethylamine. PMID- 4320042 TI - Experiments on lymph node metastasis by intralymphatic inoculation of rat ascites tumor cells, with special reference to lodgement, passage, and growth of tumor cells in lymph nodes. PMID- 4320043 TI - Eighth cranial nerve affection in leprosy. PMID- 4320044 TI - Glomus jugulare tumors: a comprehensive study with report of case. PMID- 4320045 TI - A composite malignant tumour of the elderly female breast. AB - A composite malignant tumour arising in the breast of an elderly woman is described. The cystic tumour containing areas of squamous metaplasia, bone formation, adenocarcinoma, and osteosarcoma was surrounded by the typical changes of mammary dysplasia (fibroadenosis). The classification and acceptance of such tumours is highly debatable. There is no one acceptable classification of breast sarcomas and hence the prognosis of such neoplasms, particularly those containing heterologous tissues, is poorly defined. Evidence is presented in support of such composite tumours as being definite entities which arise from the closely associated epithelial and mesenchymal components of the breast simultaneously. PMID- 4320046 TI - An AutoAnalyzer method for estimating serum glyceride glycerol using a glycerokinase procedure. AB - THE GLYCERIDE GLYCEROL ANALYSIS DEPENDS, AFTER SAPONIFICATION OF TRIGLYCERIDES, ON A LINKED ENZYMATIC PROCEDURE USING GLYCEROKINASE, PYRUVATE KINASE, AND LACTATE DEHYDROGENASE: the final conversion of NADH to NAD(+) is followed fluorimetrically. Twenty analyses can be performed per hour on the AutoAnalyzer; recoveries of added triglycerides ranged between 90 and 104%. In a mixed male and female group the normal range for glyceride glycerol was 2.5 to 15.5 mg/100 ml (0.2-1.4 mmol/l) fasting, and 2.5 to 18.0 mg/100 ml (0.2-1.6 mmol/l) postprandially using fresh serum. There was a significant rise postprandially in older men. PMID- 4320047 TI - Sphenoidal mucocoele. PMID- 4320048 TI - Hydrogen exchange as a probe of the dynamic structure of DNA. II. Effects of base composition and destabilizing salts. PMID- 4320049 TI - SV40 DNA strand selection by Escherichia coli RNA polymerase. PMID- 4320050 TI - DNA replication in SV40 infected cells. I. Analysis of replicating SV40 DNA. PMID- 4320051 TI - The isolation and purification of a chemotaxis-promoting factor for cancer cells (carinoegresin) from cancerous tissues and its physico-chemical properties. PMID- 4320052 TI - Glomus tumours. PMID- 4320053 TI - Replication of murine and feline RNA-containing C-type viruses in human lymphoblastoid cells. PMID- 4320054 TI - Effects of calcium on ACTH stimulation of the adrenal: separation of hormone binding from adenyl cyclase activation. PMID- 4320055 TI - Morphological classification of mammary tumours in the mouse. PMID- 4320056 TI - Adenoid cystic carcinoma of the breast. Review of the literature and clinico pathologic study of seven patients. PMID- 4320057 TI - [Afferent connections to fast and slow conducting pyramidal tract neurons]. PMID- 4320058 TI - Cortically induced inhibition in the dorsal column nuclei of monkeys. PMID- 4320059 TI - Adenosine 3',5'-cyclophosphate and (Na plus-K+) activated adenosine triphosphatase. PMID- 4320060 TI - Changes in the composition of serum beta-lipoproteins in rats after partial hepatectomy and adrenalectomy. PMID- 4320061 TI - Pyrophosphate, phosphonates and pyrophosphatases in the regulation of calcification and calcium homeostasis. PMID- 4320063 TI - Growth characteristics of adrenergic nerves in the adult rat. Fluorescence histochemical and 3H-noradrenaline uptake studies using tissue transplantations to the anterior chamber of the eye. PMID- 4320062 TI - [Benign and malignant vulvar sweat-gland neoplasms. (Hidradenoma and hidradenocarcinoma)]. PMID- 4320064 TI - Effect of corticosteroids on corneal collagenase of rabbits. PMID- 4320066 TI - The radiotherapy of malignant disease of the kidney and ureter. PMID- 4320065 TI - [Latent adenovirus infections in children and adults (otorhinolaryngologic studies in the Rostock area]. PMID- 4320067 TI - Relationship between stages of sleep and gastric motility. PMID- 4320068 TI - The effect of oxotremorine and atropine on cGMP and cAMP levels in mouse cerebral cortex and cerebellum. PMID- 4320069 TI - Adenyl cyclase in human hair follicles: its inhibition by dihydrotestosterone. PMID- 4320071 TI - Electron paramagnetic resonance (EPR) studies on heme-heme interaction in aggregate heme and multi-heme systems. PMID- 4320070 TI - Oxidation of extramitochondrial NADH by rat liver mitochondria. Possible role of ACYL-SCoA elongation enzymes. PMID- 4320072 TI - ACTH activation of glycolysis in the rat adrenal gland. PMID- 4320073 TI - Induction of melanocytogenesis in explants of Curassius auratus L the xanthic goldfish by dibutyryl-cAMP. PMID- 4320074 TI - The effect of trypsin and heat treatment on oxidative phosphorylation in Mycobacterium phlei. PMID- 4320075 TI - [Statistical characteristics of signal transmission in the nervous system]. PMID- 4320076 TI - [Nature of the dark EPR signal in photosynthesizing systems]. PMID- 4320077 TI - [Sarcoid type multiple granulomas of the parotid]. PMID- 4320078 TI - [Caustic burns of the trachea]. PMID- 4320079 TI - [Culture in vitro of cells of primary cancer of human liver]. PMID- 4320080 TI - RNA synthesis in polyoma virus-infected cells. I. Pattern of formation of polyribosome-associated messenger RNA during productive infection. PMID- 4320081 TI - Partial purification of phosphodiesterase I from microsomes of rat intestinal mucosa. PMID- 4320082 TI - Some properties of phosphodiesterase I from microsomes of rat intestinal mucosa. PMID- 4320084 TI - Sleep and sleep disturbances in young children. Sensible management depends upon understanding. PMID- 4320083 TI - Studies in clinical shock and hypotension. VII. Renal hemodynamics before and during treatment. PMID- 4320085 TI - The major histocompatibility antigens in various species. PMID- 4320086 TI - Studies with ubiquinone-depleted submitochondrial particles. Effects of extraction and reincorporation of ubiquinone on the kinetics of succinate dehydrogenase. PMID- 4320087 TI - Cooperative binding of manganese (II) to transfer RNA. PMID- 4320088 TI - Electron spin resonance of pteridine radicals and the structure of hydropteridines. PMID- 4320089 TI - Angiotensin-catecholamine interactions in the rabbit. PMID- 4320090 TI - Effects of emetine on neuromuscular transmission. PMID- 4320091 TI - Patterns of neurological practice in Calcutta and West Bengal (India). PMID- 4320092 TI - Plasma membranes: their ATPase activity and role in cancerogenic mechanism. PMID- 4320093 TI - Electron microscopic studies of the ATPase activity in the nuclei of neoplastic and normal liver parenchyma cells of man and of experimental animals. PMID- 4320094 TI - Local enzymatic changes in muscle fibre in muscular diseases. PMID- 4320095 TI - Fine structure of nuclear bodies in the human trophoblast. PMID- 4320096 TI - [Enzymatic histochemical studies of the angle of the anterior chamber. 1. Some enzymes relating to phosphoric acid metabolism]. PMID- 4320097 TI - [Vincristine sulphate therapy in glioblastoma of the brain]. PMID- 4320099 TI - [Prevention of tumor growth by immunization of hamsters with x-irradiated SV40 transformed cells]. PMID- 4320098 TI - [Effect of conjugates with purine, pyrimidine or DNA on the development of SV40 tumor in hamsters]. PMID- 4320100 TI - Studies on the sites of action of ethacrynic acid and furosemide during angiotensin infusion. PMID- 4320101 TI - Molecular weight of rhinovirus ribonucleic acid. PMID- 4320102 TI - An indirect ferritin-tagged antibody system for foot-and-mouth disease virus. PMID- 4320103 TI - Lactate dehydrogenase isoenzymes during the development of experimental fibrosis. PMID- 4320104 TI - The contamination of purified collagenase preparations by clostridiopeptidase B (clostripain): the potential effect of studies utilizing collagenase as a highly specific structural tool. PMID- 4320105 TI - Spontaneous burned-out acromegaly with preservation of normal human growth hormone responses: diagnostic, historical, theoretical, and treatment aspects. PMID- 4320106 TI - Further evidence for angiotensin-sodium interaction in central control of fluid balance. PMID- 4320107 TI - Australia antigen and viral hepatitis in Sydney. A hospital series. PMID- 4320108 TI - [Clinical picture of cylindroma]. PMID- 4320109 TI - Inhibition of spontaneous sympathetic nerve activity by the antihypertensive agent Wy-8678. PMID- 4320110 TI - "Home from hospital". PMID- 4320111 TI - Intravenous infusion of angiotensin after surgical treatment of arterial hypertension. PMID- 4320112 TI - The effect of prostigmin on the basal electromyogram in myasthenia. PMID- 4320113 TI - Effect of intravenously injected tubercle bacilli (BCG) on transport of quartz dust via the pulmonary lymphatics. An experimental study on rats. PMID- 4320114 TI - [Documentation of forensic blood typing data]. PMID- 4320115 TI - [Forensic osteology. IV. CLOSURE OF THE CRANIAL SUTURES WITH SPECIAL CONSIDERATION OF THE QUESTION OF AGE DETERMINATION]. PMID- 4320116 TI - [Allergic alteration of neutrophils in the interaction with bacterial allergens and viral antigens in the clinical picture of neuroinfectious diseases]. PMID- 4320117 TI - Changes in properties of contractile proteins and membrane system of dried and rehydrated frog muscles. PMID- 4320118 TI - [Abrikosoff's tumor]. PMID- 4320119 TI - Zoster, reinfection or activation of latent virus? Observations on the antibody response. PMID- 4320120 TI - Metabolic and toxic effects of mithramycin during tumor therapy. PMID- 4320121 TI - Hypertension and the lupus syndrome. PMID- 4320122 TI - Neurological, electroencephalographic, and virological findings in febrile cheldren. PMID- 4320124 TI - Enzyme histochemistry of the developing ovary and endometrium. PMID- 4320123 TI - Cytomegalovirus infection in early infancy. Five atypical cases. PMID- 4320125 TI - Observations on the cytokinetics of malignant tumours in children. PMID- 4320126 TI - The aetiology of infectious bovine keratoconjunctivitis in Queensland. 2. Adenovirus. PMID- 4320127 TI - Studies on equine herpesviruses. 1. Characterisation of a strain of equine rhinopneumonitis virus isolated in Queensland. PMID- 4320128 TI - [Phototransformation of porphyrins in frozen solutions. Photoelectron transport in sulfuric acid solutions of etioporphyrin]. PMID- 4320130 TI - [Exclusion of the scatter effect of threshold levels in the determination of intercorrelations of neuron impulse activity]. PMID- 4320129 TI - [EPR study of energy-dependent processes in metabolizing mitochondria]. PMID- 4320131 TI - [EPR signals of free radicals in lyophilized and frozen plant preparations]. PMID- 4320132 TI - WHO collaborative studies on enterovirus reference antisera. Third report. AB - This paper smmarizes the results of the third part of co-operative studies undertaken by the WHO International Reference Centre for Enteroviruses and a number of WHO Regional Virus Reference Centres and WHO Virus Collaborating Laboratories and other laboratories in a comprehensive testing programme of enterovirus equine antisera prepared for long-term use as reference antisera. The studies were designed to appraise the specificity of the immune serum of horses inoculated with prototype enteroviruses (coxsackie-viruses A1, A5, A6, A12 and A22 and echoviruses 5, 6, 13-16, 18-20, 22-26, 29 and 32). Tests for neutralizing antibody were performed not only against the homologous viruses but also against regional homotypic strains. Tests for heterotypic antibody were made against the entire group of enteroviruses (except enterovirus 68), reoviruses 1-3, and adenoviruses 1-11, 13-17 and 19-22. Final vials of the dried serum were provided for the tests. Each serum sample represented a pool of the individual bleedings taken from a group of horses before and after immunization with each virus antigen. The results showed that the homologous geometric mean titres of 9 of 16 echovirus immune sera were 10 000 or above while the other 7 ranged from 2000 to 8000. The homologous antibody titre of one coxsackievirus type A serum was about 2000 while the titres of the other 4 type A sera ranged from about 5000 to 15 000. All corresponding pre-inoculation sera were negative. The results of the homotypic tests, though limited in number, showed the usefulness of the sera. Data on heterotypic antibody titres, if any, are recorded for gidance in the use of the sera. Co-operative testing of 19 additional enterovirus equine sera is now in progress. PMID- 4320134 TI - Temporal secretory responses of cultured hamster adrenals. PMID- 4320133 TI - Genesis of antinuclear antibody in NZB-W mice: role of genetic factors and of viral infections. PMID- 4320135 TI - Distribution of glutamate in spinal roots of different species: a comparative study. PMID- 4320136 TI - [Corticotropin control of adrenal corticosteroidogenesis in lower vertebrates (reptiles, teleosts)]. PMID- 4320138 TI - [Lymphocyte transformation in human blood in contact with smallpox virus]. PMID- 4320137 TI - [Antiradical tissue activity and radiosensitivity]. PMID- 4320139 TI - [Histochemical study of cathepsin C in the spleen during the early stages of immunogenesis]. PMID- 4320141 TI - [Alpha 1-fetoprotein and cancer]. PMID- 4320140 TI - [Presynaptic nature of the extinction by tetanus toxin of postsynaptic inhibition]. PMID- 4320142 TI - [Significance of alpha 1-fetoprotein in primary hepatomas]. PMID- 4320144 TI - [Antiviral activity of benzimidazole derivatives. II. Bisbenzimidazole derivatives]. PMID- 4320143 TI - [Audiological examinations in acoustic tumors]. PMID- 4320145 TI - Familial ovarian carcinoma. PMID- 4320146 TI - An unusually large glomangioma simulating osteoarthritis of the hip. PMID- 4320147 TI - Adenyl cyclase activity in brown adipose tissue of young rats. PMID- 4320148 TI - Stimulation of luteinizing hormone release in vitro by dibutyryl-cyclic-AMP and theophylline. PMID- 4320149 TI - The control of iodine deficiency. PMID- 4320151 TI - A trial to assess the value of xiphoid cartilage measurements and carcass weight for age determination in sheep. PMID- 4320150 TI - The value of isotope scanning in the diagnosis of brain tumors in childhood. PMID- 4320152 TI - Equine rhinopneumonitis virus infection in New Zealand. PMID- 4320153 TI - [Anatomy, physiology and embryology of the human adrenal]. PMID- 4320154 TI - [Biochemical diagnosis of adrenal cortex function]. PMID- 4320155 TI - [Regulation of adrenal cortex function]. PMID- 4320156 TI - [Stress--theory and practice]. PMID- 4320157 TI - [Role of the adrenal cortex in the pathogenesis of hypertension]. PMID- 4320158 TI - [Adrenal cortical function during and after prolonged treatment with corticosteroids]. PMID- 4320159 TI - [Antigenic components of the mucosa of the human small intestine]. PMID- 4320160 TI - Effect of angiotensin and norepinephrine on renal transport of sodium. PMID- 4320161 TI - [Experimental herpes simplex virus infection of the skin of hairless mice]. PMID- 4320162 TI - [Vestibular function disorders in idiopathic facial paralysis (problems of localization and compensation)]. PMID- 4320163 TI - [Control of diuresis. Interference of the renal effects between homeostasis of the extracellular fluid volume and angiotensin II in man in sustained hypotonic polyuria]. PMID- 4320166 TI - The immunodepressive effect of rinderpest virus. PMID- 4320164 TI - The human primary immune response to keyhole limpet haemocyanin: interrelationships of delayed hypersensitivity, antibody response and in vitro blast transformation. PMID- 4320165 TI - The effect of thymectomy, hemi-thymectomy and sham thymectomy on experimental myasthenia gravis in guinea-pigs. PMID- 4320167 TI - Surface antigens on lymphoblastoid cells derived from nasopharyngeal carcinoma. PMID- 4320168 TI - [Aspects of water-electrolyte metabolism and aldosterone therapy in orthostatic arterial hypotension: considerations suggested by a case in advanced age]. PMID- 4320169 TI - [Lethal midline granuloma]. PMID- 4320170 TI - [Intramuscular inclusion bodies in gynecomastia]. PMID- 4320171 TI - [Chemotherapy of malignant tumors in children]. PMID- 4320172 TI - Differential diagnosis of virus infections of the bovine teat skin by electron microscopy. PMID- 4320173 TI - [Analysis of errors in the diagnosis of Paget's cancer]. PMID- 4320175 TI - Clinical evaluation of percutaneous transhepatic cholangiography. PMID- 4320174 TI - [Disturbance of the cellular immunoreaction at the initial stage of acute infectious hepatitis]. PMID- 4320176 TI - Confirmation of acetylcholine in perfusates of the stimulated vagus nerve by pyrolysis gas chromatography. PMID- 4320177 TI - The effect of NaCl and LiCl on vasopressin-sensitive adenyl cyclase. PMID- 4320178 TI - Adenosine 3',5'-monophosphate. Demonstration of a binding site specific for the cyclic nucleotide. PMID- 4320179 TI - The effect of ammonia on the energy metabolism of the rat brain. PMID- 4320180 TI - Enzymic hydrolysis of adenosine 3',5'-monophosphate by rat and beef heart supernatant. PMID- 4320181 TI - Prevalence of murine C-type RNA virus group specific antigen in inbred strains of mice. PMID- 4320182 TI - [Clinical studies of cancer of the liver cell and metastatic liver cancer]. PMID- 4320183 TI - [Multiple glomus tumors]. PMID- 4320185 TI - [Diagnosis and treatment of amebiasis]. PMID- 4320184 TI - [Clinical repercussions of poisonings of the central and peripheral nervous system]. PMID- 4320186 TI - [Multiple unilateral paralysis of the cranial nerves (Garcin's syndrome) due to chemodectoma of the glomus jugulare]. PMID- 4320187 TI - [Angiography of primary liver cancer]. PMID- 4320188 TI - The chromosomal aberration of double-minutes in three gliomas. PMID- 4320189 TI - Virus-like particles in cultured human glioma. PMID- 4320190 TI - Goniodysgenesis and hereditary juvenile glaucoma. A clinical study of a Swedish pedigree. PMID- 4320192 TI - Enzymic determination of uracil nucleotides in tissues. PMID- 4320193 TI - Improved automated lactate determination. PMID- 4320191 TI - Recent advances in immunologic diagnosis of digestive tract cancer. PMID- 4320195 TI - Use of colloidal silica in density gradients to separate intact chloroplasts. PMID- 4320194 TI - Decomposition of dibutyryl cyclic AMP in aqueous buffers. PMID- 4320196 TI - Determination of total nucleic acids in plant tissue. PMID- 4320197 TI - Note on the formation of alkyl phosphates in plant extracts. PMID- 4320198 TI - An enzymic assay for ribitol. PMID- 4320199 TI - [Hepatic cancer and mycotoxins]. PMID- 4320200 TI - [Adaptation of the vesicular stomatitis virus to Drosophila melanogaster]. PMID- 4320201 TI - Antiviral activity of oxidized polyamines and aldehydes. PMID- 4320202 TI - Effect of epinephrine on hepatic glycogen phosphorylase and synthetase activities in normal and pertussis-sensitized rats. PMID- 4320203 TI - Effect of potassium ion, theophylline and propranolol on the biphasic lipolytic response to some catecholamines. PMID- 4320205 TI - Adsorption of foot-and-mouth disease virus by muscle, kidney, lung and brain from infant and adult mice. AB - Adsorption of foot-and-mouth disease (FMD) virus by minced and homogenized muscle, kidney, lung, and brain from infant and adult mice was compared under various experimental conditions to determine if there were differences in adsorption characteristics. The following factors were studied: relative ability to adsorb virus, sedimentation of the adsorbing components, heat lability of the components, virus elution, and recovery of cell-associated virus. The results indicated that the adsorbing components in brain were different from those in kidney and lung. Infant mouse muscle, the only tissue tested that was highly susceptible to FMD virus in vivo, had some adsorption characteristics similar to brain and others similar to kidney and lung. The possibility of a relationship of these characteristics to the susceptibility or resistance of the tissue donors was discussed. PMID- 4320206 TI - Virological examination of bovine mammary lymph nodes. AB - Mammary lymph nodes from 42 Hereford cows culled for poor reproductive performance were examined for cytopathogenic virus and hemadsorption. No evidence of viral infection was detected using the methods employed. Serum from all the animals gave positive reactions to the hemagglutination-inhibition test for bovine myxovirus parainfluenza 3. Six of 12 had neutralizing antibody against bovine virus diarrhea virus, but none of the 12 had neutralizing antibodies against infectious bovine rhinotracheitis virus. PMID- 4320204 TI - Uptake of probenecid by rat liver slices. PMID- 4320207 TI - Kinetic measurement of serum glutamate dehydrogenase activity in the presence of oxamic acid and L-leucine. PMID- 4320208 TI - [The biochemistry of methoxy indoles. Spectrofluorometric determination of methoxy-5-tryptamine]. PMID- 4320209 TI - Comparative study of the development of enzymes involved in carbohydrate and amino acid metabolism from brain, heart, liver and kidney of chick embryo. PMID- 4320210 TI - The nature of the thermal optimum for lungfish lactate dehydrogenase. PMID- 4320211 TI - Substrate specificity of thyroid adenyl cyclase. PMID- 4320212 TI - Stimulation of the respiration of polymorphonuclear leucocytes by phospholipase C. PMID- 4320213 TI - Mechanism of extraction of angiotensin II in coronary and renal circulations. PMID- 4320214 TI - Cerebro-cortical pyruvate kinase inhibition by L-phenylalanine and p chlorophenylalanine. PMID- 4320215 TI - [Functioning and non-functioning tumors of the insular pancreas. Pathology, clinical aspects and therapy]. PMID- 4320216 TI - [Primary liver carcinoma as a complication of liver cirrhosis]. PMID- 4320217 TI - [Molecular aspects of allosterism in hemoglobin]. PMID- 4320218 TI - [Regulation of threonine metabolism by adenine nucleotides]. PMID- 4320219 TI - [Symptomatology of Wernicke's encephalopathy (poliencephalitis haemorrhagica superior)]. PMID- 4320220 TI - [Effect of chemical disinfectants on influenza, vaccinia and poliomyelitis viruses]. PMID- 4320221 TI - [Sarcomatous transformed fibromas of the male mammary gland]. PMID- 4320222 TI - [Action of the amino acids plus sulfite combination on the growth of Clostridium. Trypticase-glucose-tyrosine-sulfite (TGTS) medium]. PMID- 4320223 TI - [Bronchiolo-alveolar carcinoma]. PMID- 4320224 TI - The inhibition of mitochondrial respiration by beta-benzal butyric acid and the possible relationship to cholesterol biosynthesis. PMID- 4320225 TI - Effect of ethanol on glycerol metabolism in rat liver during different hormonal conditions. PMID- 4320226 TI - Effect of metronidazole on liver alcohol dehydrogenase. PMID- 4320228 TI - The effects of naps on nocturnal sleep: influence on the need for stage-1 REM and stage 4 sleep. PMID- 4320227 TI - Putative neurotransmitters in the brain: selective neuronal uptake, subcellular localization, and interactions with centrally acting drugs. PMID- 4320230 TI - Transferrable thoughts. PMID- 4320229 TI - Sleep and REM deprivation in the rat: effect of dexamethasone, a preliminary study. PMID- 4320231 TI - [Significance of the various phagocytic cells for the self-cleaning of the lungs from quartz dust]. PMID- 4320232 TI - [Level and distribution of various fractions of phospholipids in the spinal cord]. PMID- 4320233 TI - [Action of ethionine and methionine on hepatocytes in culture]. PMID- 4320234 TI - [Role of sympathetic vasomotor tonus in the renal vasoconstrictive action of angiotensin]. PMID- 4320235 TI - [A simple method of purification by silica in microgranular form of radio iodinated somatotropic hormone]. PMID- 4320236 TI - [Australian antigen and canine hepatitis virus]. PMID- 4320237 TI - [High-sodium diet modifies neither blood potassium nor the response to administration of corticostimulin in the anesthetized rat]. PMID- 4320238 TI - The stimulation of oogenesis in Pieris brassicae by the juvenile hormone derivative farnesenic acid ethyl ester. PMID- 4320239 TI - Adrenocortical lipoid hyperplasia induced in rats by aniline. PMID- 4320240 TI - In vivo conversion of corticosterone into aldosterone in rats treated with ACTH or submitted to stress. PMID- 4320241 TI - Action of sodium dodecyl sulfate on electron transport enzymes of Rhodospirillum rubrum. PMID- 4320242 TI - The effect of theophylline on the actions of pancreozymin and secretin. PMID- 4320243 TI - Evidence for a spinal sympathetic regulation of cardiovascular functions. PMID- 4320244 TI - Tyrosine hydroxylase activity in a transplantable islet cell tumour of golden hamster. PMID- 4320245 TI - [The EB-virus and its possible connection with infectious mononucleosis and Burkitt's lymphoma]. PMID- 4320246 TI - [The importance of alpha-fetoprotein in the diagnosis of liver tumors]. PMID- 4320247 TI - Quantitative determination of ethanol by gas liquid chromatography after collection from the vapor phase on anhydrous magnesium perchlorate. PMID- 4320248 TI - The glomerular cappillary wall. PMID- 4320249 TI - [Parkinson's syndrome. 10. Effects of psychopharmacological agents on central monoamine neurons]. PMID- 4320251 TI - Epidemiological studies relating to the control of Marek's Disease. PMID- 4320250 TI - Drug therapy and curability of childhood cancer. PMID- 4320252 TI - [Attempts to use the interference phenomenon for detecting several mice leukemia viruses in tissue culture]. PMID- 4320253 TI - [Several properties of the serum factor from normal animals and animals with tumors in the gel precipitation reaction]. PMID- 4320254 TI - Reduction of cytochrome-c by Haemonchus contortus larvae. PMID- 4320256 TI - Schwann cell dysfunction in uraemia. AB - Examination of individual sural nerve fibres revealed segmental demyelination, in 10 out of 12 subjects with uraemia. Peripheral neuropathy was present in only two cases. The complex biochemical changes occurring with dialysis unmask the underlying demyelination in subjects with a latent neuropathy. This would explain the precipitation of a neuropathy in those subjects submitted for repeated dialysis. The possible correlation between creatinine retention, dialysis, and metabolic dysfunction in the Schwann cell system is discussed. PMID- 4320255 TI - Rheumatoid neuropathy: a histological and electrophysiological study. AB - Peripheral nerves in five patients with rheumatoid neuropathy were examined electrophysiologically and by sural nerve biopsy. There was close correlation between the clinical severity of the disease and the degree of nerve damage found histologically and by EMG. Group 1 patients with a mild distal sensory neuropathy showed varying degrees of axonal degeneration in the large myelinated fibres and some segmental demyelination. Group 2 patients with a severe, rapidly progressive sensori-motor neuropathy had extensive loss of myelinated fibres. In one case all the large fibres had degenerated. The second case had lost both large and small myelinated fibres together with many of the non-myelinated axons. The major nerve damage in both groups appeared to be axonal degeneration but some segmental demyelination was detected. Occlusive vascular disease in the vasa nervorum was considered to be the major cause of the nerve damage. PMID- 4320257 TI - [Drugs and children. 3. The treatment of asthma attacks]. PMID- 4320258 TI - [Mammography in the diagnosis of phyllode tumor]. PMID- 4320259 TI - Changes of simple and complex spike activity of cerebellar purkinje cells with sleep and waking. AB - Action potentials of cerebellar Purkinje cells were observed in intact monkeys during sleep and waking. Purkinje cells exhibit two sorts of action potentials, called simple and complex spikes, and these two sorts of spikes were differently affected by sleep. Simple-spike activity (generated by the parallel fiber inputs to the Purkinje cell) was highest during sleep with rapid eye movements as compared with both waking and sleep with electroencephalographic slow waves. In contrast, complex-spike activity (generated by the climbing fiber inputs to the Purkinje cell) was lowest during sleep with rapid eye movements. The complex action potential of the Purkinje cell consists of an initial large spike followed by one or more smaller secondary spikes, and the number of these secondary spikes was found to be independent of the background discharge frequency of the simple spike. This independence suggests a possible role of presynaptic factors rather than the excitability level of the Purkinje cell itself in determining the number of secondary discharges occurring in the complex spike. PMID- 4320260 TI - [Acute myelo-monocytic leukemia with atypical naphthol-AS-D-chloracetate esterase positive eosinophils]. PMID- 4320261 TI - Lipid metabolism. PMID- 4320262 TI - Glycogen metabolism and glycolytic enzymes. PMID- 4320263 TI - Biochemistry of addiction. PMID- 4320264 TI - Hemoglobin. PMID- 4320265 TI - [Ultrastructural morphometric study on rat liver cells in the early regenerative phase after partial hepatectomy]. PMID- 4320266 TI - [2 cases of post abortum perfringens septicemia. Death]. PMID- 4320267 TI - [Histochemical identification of leucine aminopeptidase activity in cellular elements of connective tissue during inflammation]. PMID- 4320268 TI - [Injurious effect of 6-azauridine on the multiplication of human cytomegalovirus]. PMID- 4320269 TI - [Some properties of the replicative form of mouse encephalomyocarditis virus RNA]. PMID- 4320270 TI - [Effect of insulin hypoglycemia and electrodermal stimulation on the content and intensity of metabolism of mono-, di- and triphosphoinositides in the rat brain]. PMID- 4320271 TI - [Clinical action of "Flaviastase" in dyspeptic syndromes]. PMID- 4320272 TI - Recent results with percutaneous cordotomy. PMID- 4320273 TI - [Prognosis in Paget's disease of the nipple]. PMID- 4320274 TI - [Inflammatory changes in the heart in infants (analysis of autopsy data)]. PMID- 4320275 TI - Micropuncture investigation of the effect of altered thyroid function on the cation concentrations and equilibrium potentials in rat thyroid colloid. PMID- 4320276 TI - A comparative study of the effects of ACTH, hydrocortisone and prednisolone in the hypersensitive reactions produced with the protein components of Hymenolepis nana in albino mice. PMID- 4320277 TI - [Isolation of a thermo-adaptable strain of Entamoeba histolytica]. PMID- 4320278 TI - [Tolerance and abstinence syndromes after small doses of hypnotics]. PMID- 4320279 TI - [Angina pectoris. Treatment of night attack]. PMID- 4320280 TI - [Skin deformity tumors in young pigs induced by transplancental action of ethyl nitroso-urea. Genesis of hidradenoma]. PMID- 4320281 TI - Characterization of an [125 I]-insulin binding plasma membrane fraction from rat liver. PMID- 4320282 TI - Antipoliovirus action of ethine compounds. PMID- 4320283 TI - Presence of two 3'-5'-cyclic AMP phosphodiesterases in rat kidney and frog bladder epithelial cells extracts. PMID- 4320284 TI - The adenyl cyclase of skin. I. Measurement and properties. PMID- 4320285 TI - The adenyl cyclase of skin. II. Adenyl cyclase levels in atopic dermatitis. PMID- 4320287 TI - Nobel prize. PMID- 4320286 TI - Antagonism of some smooth muscle actions of prostaglandins by polyphloretin phosphate. AB - 1. The antagonism of the smooth muscle stimulating actions of PGF(2a) and PGE(2) by polyphloretin phosphate (PPP) was studied on several isolated smooth muscle preparations and on the blood pressure of the anaesthetized rabbit.2. PPP (2.5-20 mug/ml) reversibly inhibited contractions of the jird colon produced by PGE(2) or PGF(2a); PGF(2a) was more readily antagonized than PGE(2).3. PPP (2.5-30 mug/ml) reversibly antagonized contractions produced by PGE(2) and PGF(2a) on the isolated rabbit jejunum and uterus. In these preparations PPP antagonized PGE(2) as readily as PGF(2a).4. It is concluded that PPP is a selective antagonist to the prostaglandins on these tissues, for contractions produced by other agonists, such as acetylcholine, angiotensin, 5-hydroxytryptamine and bradykinin were not reduced by concentrations of PPP which markedly antagonized responses to the prostaglandins.5. Intravenous injections of PPP (25-200 mg/kg) resulted in a variable antagonism to the fall in blood pressure produced by intravenous injections of PGF(2a) in the anaesthetized rabbit; vasodepressor responses produced by PGE(2) and acetylcholine were not antagonized.6. The mechanism of this antagonism by PPP is not clear and must await further investigation. PMID- 4320288 TI - [Stimulation of adenyl-cyclase in lysates of human circulating lymphocytes under the influence of phytohemagglutinin or antilymphocyte serum]. PMID- 4320289 TI - [Internal (short) feedback loops in the hypophyseal-hypothalamic system]. PMID- 4320290 TI - The relationship of dietary potassium intake to the aldosterone stimulating properties of ACTH. PMID- 4320291 TI - [Guanyl cyclase. Biosynthesis of guanosine-3',5'-monophosphate in kidney and other rat tissues]. PMID- 4320292 TI - Leucyl-tRNA synthetase. Purification of two interconvertible forms and evidence for an interconversion factor. PMID- 4320293 TI - The identification of a reactive lysine residue in lobster glyceraldehyde-3 phosphate dehydrogenase. PMID- 4320294 TI - Group-specific antigen of murine leukemia viruses in mice of low-leukemic strains. PMID- 4320295 TI - Immunofluorescent study of the group-specific antigen of murine leukemia viruses. PMID- 4320296 TI - Rous sarcoma recurrence and Rous sarcoma virus growth in chicken muscle. PMID- 4320298 TI - Transformation of human cells by polyoma and Rous sarcoma viruses mediated by inactivated Sendai virus. PMID- 4320297 TI - Effect of prolonged cultivation of SV40-transformed mouse cells in bromide oxyuridine or pretreatment with mitomycin C on rescue of SV40. PMID- 4320299 TI - Development of resistance of Novikoff hepatoma to 5-fluoro-2'-deoxyuridine. PMID- 4320300 TI - Further studies on tumor-producing activity in adult by embryonic tissue cultures exposed to a virus and grafted before manifestation of morphologic transformation. PMID- 4320301 TI - On the surface structure of murine ascites tumors. I. Interactions with various phytoagglutinins. PMID- 4320303 TI - Bone metabolism. The acute effects of hormones, vitamin D3, and acidosis during in vivo perfusion ff adult dog forelimbs. PMID- 4320302 TI - Demonstration and characterization of antibody in tears following intranasal vaccination with inactivated type 13 rhinovirus: a preliminary report. PMID- 4320304 TI - Intracranial removal of pituitary adenomas. An evaluation of varying degree of excision from partial to total. PMID- 4320305 TI - [Chronic invagination due to cecal cancer in an African]. PMID- 4320307 TI - Formate, a new component of bacterial exopolysaccharides. PMID- 4320306 TI - DNA chain growth: in vivo and in vitro synthesis in a DNA polymerase-negative mutant of E. coli. PMID- 4320308 TI - [Splenectomy in malignancy of the upper part of the abdomen]. PMID- 4320309 TI - [Intraneural topography of cancer of the nerve trunk of the arm]. PMID- 4320310 TI - [Differential diagnosis in viral serous meningitis in children]. PMID- 4320311 TI - Treatment of bronchial asthma with synthetic long-term corticotrophin. PMID- 4320312 TI - [Piimary tumours of the small intestine]. PMID- 4320313 TI - [Leukemia and virus: current concept]. PMID- 4320314 TI - Preparation and some properties of isolated islests of Langerhans from rabbit pancreas. PMID- 4320315 TI - Susceptibility of the agouti (Dasyprocta aguti) to foot-and-mouth disease virus. PMID- 4320316 TI - Effect of synthetic human 1,39-corticotrophin on blood glucose level in mice. PMID- 4320317 TI - Influence of corticosteroids and chlorpromazine on the release of vasopressin from isolated neural lobes of rats. PMID- 4320319 TI - Competition of alpha-ketobutyrate with pyruvate for the mammalian pyruvate dehydrogenase complex. PMID- 4320318 TI - Regulation of the production of oestrogen precursors in the foetus. PMID- 4320320 TI - Histocompatibility studies in patients with trophoblastic tumors. PMID- 4320321 TI - [Pharmacological study of the antibiotic sibiromycin]. PMID- 4320322 TI - [Effect of prodigiozan on the defense reaction of the organism at endonasal administration]. PMID- 4320324 TI - Mesenteric chemodectoma. Report of a case. PMID- 4320323 TI - Bronchial adenomas. PMID- 4320326 TI - [Heterologic mesodermal tumors of the uterus]. PMID- 4320325 TI - [Pathologic anatomy of rectal cancer treated by intra-arterial administration of 5-fluoruracil]. PMID- 4320327 TI - [Malignant tumors in the knee region with an atypical course]. PMID- 4320328 TI - Nonhormonal chemotherapy of tumors metastatic to bone. PMID- 4320329 TI - Adenovirus, RS virus and M. pneumoniae infections in young population of Prague in 1962-1967. PMID- 4320331 TI - [Juvenile angiofibroma]. PMID- 4320330 TI - Extraction of prostaglandin from AgNO3-impregnated silica gel layers for biological assay. PMID- 4320333 TI - [Nerve tissue tumors of the nasal fossa]. PMID- 4320332 TI - [Ovarian neoplasms. A retrospective study of 990 cases]. PMID- 4320334 TI - Chromosomes of SV40 transformed human amnion cells after mycoplasma infection. PMID- 4320335 TI - Application of cell culture to production of Japanese encephalitis virus hemagglutinin. PMID- 4320336 TI - Plaque assay of cytomegalovirus strains of human origin. PMID- 4320337 TI - Functional failures of "fibrocystic" fibroblasts. PMID- 4320338 TI - Renin depletion in the dog. PMID- 4320339 TI - Specific collagenase from germ-free rat gingivae. PMID- 4320340 TI - Effect of immune syngeneic lymphoid cells on plating efficiency of a polyoma virus-induced neoplasm. PMID- 4320341 TI - Viral interference in the brains of mice infected subcutaneously with herpes simplex virus. PMID- 4320342 TI - [Formation of toxins by Clostridium perfringens types C and D]. PMID- 4320343 TI - [Morbus Paget, report of 2 cases]. PMID- 4320344 TI - [News in microbiology]. PMID- 4320346 TI - Extraction of amines as complexes with inorganic anions. 5. Studies of partition systems with organic phases containing two agents solvating ion pairs. PMID- 4320345 TI - [Purification and structure of verdohemin]. PMID- 4320347 TI - Extraction of amines as complexes with inorganic anions. 6. Extraction of imipramine and desipramine ion pairs with alkyl chloride solvents. PMID- 4320348 TI - [Serotonin and the function of smooth muscles (review of the literature)]. PMID- 4320349 TI - Comparison of agar and agarose preparations for mengovirus plaque formation. AB - An agarose overlay yielded mengovirus plaques earlier and in greater size and number than overlays of chemically undefined agars with or without enhancers. Marked variability in plaque-forming efficacy of commercial agarose preparations was noted. PMID- 4320350 TI - Plasma membranes: structural analyses of neutral lipids and phospholipids of rat liver. PMID- 4320351 TI - Tumor lipids: structural analyses of the phospholipids. PMID- 4320352 TI - Tumor lipids: characterization of the lipids isolated from membranous material. PMID- 4320353 TI - Nuclear metabolism. I. Nuclear phosphorylation. PMID- 4320354 TI - A bacterial activator of frog erythrocyte adenyl cyclase. PMID- 4320355 TI - Interaction of spin-labeled myosin with substrate. PMID- 4320356 TI - Effect of ethyl biscoumacetate on the incorporation of precursors into nuclear and mitochondrial DNA of cells grown in culture. PMID- 4320357 TI - A comparison of the antagonism of TEPP and DFP by sodium fluoride and N methylpyridinium-2-aldoxime methane sulphonate in the rat isolated phrenic nerve diaphragm. PMID- 4320358 TI - Tyrocidine biosynthesis by three complementary fractions from Bacillus brevis (ATCC 8185). PMID- 4320359 TI - Biological and immunological activity of fructose 1,6-diphosphatase. Application of a quantitative displacement radioimmunoassay. PMID- 4320360 TI - Characterization of enzymatic specificity of a ribonuclease from Ustilago sphaerogena. PMID- 4320361 TI - Interaction of divalent manganese ion with adenosine triphosphate and related compounds. PMID- 4320362 TI - Isolation of peptides containing the cross-link, hydroxylysinonorleucine, from reconstituted collagen fibrils. PMID- 4320363 TI - [Synthesis and chromatographic properties of isonicotinoilhydrazide derivatives of nucleosides and nucleotides]. PMID- 4320364 TI - [Isolation, purification and properties of myocardial NAD-kinase]. PMID- 4320365 TI - [Regulation of glycogen metabolism]. PMID- 4320366 TI - [Activation of yeast glyceraldehyde-3-phosphate dehydrogenase by salts]. PMID- 4320367 TI - [The mitotic regime of human diploid cell cultures at various stages of cell transformation by SV40 virus]. PMID- 4320368 TI - [Synaptic processes in spinal neurons monosynaptically activated by the pyramidal tract]. PMID- 4320369 TI - [The effect of strychnine on the inhibitory synapses of neurons of an isolated receptor in crustacea]. PMID- 4320370 TI - [Morphofunctional characteristics of the state of spinal motor neuron synapses in tetanus intoxication]. PMID- 4320371 TI - [The electrical activity of the caudal mesenteric sympathetic ganglion following adrenalectomy and corticosteroid administration]. PMID- 4320372 TI - [The effect of ACTH, corticosteroids and sex hormones on the blood coagulating system]. PMID- 4320373 TI - [A virologic study of embryonal guinea pig and golden hamster cells infected by Rous virus (Karr-Zilber and Schmidt-Rupin strains)]. PMID- 4320374 TI - [Isolation of chick leukemia virus in live viral vaccines of egg origin]. PMID- 4320376 TI - [Practical value of polygraphic recording of sleep in man]. PMID- 4320375 TI - [Experimentation with arbovirus encephalitis. Current data]. PMID- 4320377 TI - [Electron microscopy study of the 1st stages of infection of monkey kidney cells (Rhesus resus) by SV40 virus irradiated by ultraviolet or gamma rays]. PMID- 4320378 TI - [Problems of long-term epidemiological studies on acute respiratory virus diseases. II. Longitudinal study of ARD in working collectives of the North Moravian Region]. PMID- 4320379 TI - [Prostaglandins and kidney]. PMID- 4320380 TI - Management of vascular tumors of the nasal cavity by combined irradiation and surgery. PMID- 4320381 TI - Tumours in reptiles inoculated with chicken Rous sarcoma material. PMID- 4320382 TI - Contributing factor to Mycoplasma pneumoniae produced stimulation of rhinovirus RNA synthesis. PMID- 4320383 TI - Characteristics of poliovirus type-I strains isolated in Bombay prior to and after the introduction of live oral polio virus vaccine RCT-40 degrees C (reproductive capacity at 40 degrees C temperature) marker and 'A' marker findings. PMID- 4320384 TI - A review of asthma admissions and deaths at Children's Hospital of Pittsburgh from 1935 to 1968. PMID- 4320385 TI - Sleep patterns of asthmaticchildren: all-night electroencephalographic studies. PMID- 4320386 TI - Similarities between congenital tritan defects and dominant optic-nerve atrophy: coincidence or identity? PMID- 4320389 TI - Experimental Yaba and benign epidermal monkey pox in rhesus monkeys. PMID- 4320387 TI - Temperature-sensitive simian virus 40 mutant defective in a late function. AB - A temperature-sensitive simian virus 40 (SV40) mutant, tsTNG-1, has been isolated from nitrosoguanidine-treated and SV40-infected African green monkey kidney (CV 1) cultures. Replication of virus at the nonpermissive temperature (38.7 C) was 3,000-fold less than at the permissive temperature (33.5 C). Plaque formation by SV40tsTNG-1 deoxyribonucleic acid (DNA) on CV-1 monolayers occurred normally at 33.5 C but was grossly inhibited at 38.7 C. The time at which virus replication was blocked at 38.7 C was determined by temperature-shift experiments. In shift up experiments, cultures infected for various times at 33.5 C were shifted to 38.7 C. In shift-down experiments, cultures infected for various times at 38.7 C were shifted to 33.5 C. All cultures were harvested at 96 hr postinfection (PI). No virus growth occurred when the shift-up occurred before 40 hr PI. Maximum virus yields were obtained at 96 hr PI when the shift-down occurred at 66 hr, but only about 15% of the maximum yield was obtained when the shift-down occurred at 76 hr PI. These results indicate that SV40tsTNG-1 contains a conditional lethal mutation in a late viral gene function. Mutant SV40tsTNG-1 synthesized T antigen, viral capsid antigens, and viral DNA, and induced thymidine kinase activity at either 33.5 or 38.7 C. The properties of the SV40 DNA synthesized in mutant infected CV-1 cells at 33.5 or 38.7 C were very similar to those of SV40 DNA made in parental virus-infected cells, as determined by nitrocellulose column chromatography, cesium-chloride-ethidium bromide equilibrium centrifugation, and by velocity centrifugation in neutral sucrose gradients. Mutant SV40tsTNG-1 enhanced cellular DNA synthesis in primary cultures of mouse kidney cells at 33.5 and 38.7 C and also transformed mouse kidney cultures at 36.5 C. SV40tsTNG-1 was recovered from clonal lines of transformed cells after fusion with susceptible CV 1 cells and incubation of heterokaryons at 33.5 C, but not at 38.7 C. PMID- 4320388 TI - Presence of nucleoside triphosphate phosphohydrolase activity in purified virions of reovirus. AB - A nucleoside triphosphate phosphohydrolase activity has been discovered in reovirus virions. This activity converts nucleoside triphosphates to nucleoside diphosphates in vitro. Properties of this enzyme are presented, with evidence that this activity is an integral part of the virion core. PMID- 4320390 TI - [Diagnosis of hypoglycemia of tumoral origin]. PMID- 4320391 TI - [Herpes encephalitis in an infant]. PMID- 4320392 TI - [Phyllodes tumor of the breast. Anatomo-clinical considerations and case reports]. PMID- 4320393 TI - [A comparison of the clinical and electroencephalographic signs of stem lesions following surgery for tumors of the cerebral hemispheres]. PMID- 4320394 TI - [A new method for the isolation of the antiviral antibiotic borrelidin]. PMID- 4320395 TI - Electron microscope studies on the nature of the dense bodies in smooth muscle fibres. PMID- 4320397 TI - Biliary cancer among Southwestern American Indians. PMID- 4320396 TI - [Enzyme maturation in the smell organ and telencephalon of Ambystoma mexicanum]. PMID- 4320398 TI - [The effect of 1-(5'-oxohexyl)-3,7-dimethylxanthine on heart rate following administration of propranolol and adenosine]. PMID- 4320399 TI - Sensitization by estrogens to the toxic effect of octamethyl pyrophosphoramide. PMID- 4320400 TI - Possible loci of action of 2-ethyl-4-ethylamino-6-methoxy-s-triazine for electroencephalographic and sympathetic activation in cat. PMID- 4320401 TI - Tachyphylaxis to angiotensin in man. PMID- 4320402 TI - Effect of theophylline, glucagon and theophylline plus glucagon on insulin secretion in the premature infant. PMID- 4320403 TI - [Application of the graph method in electrophysiology]. PMID- 4320404 TI - [Reactions of cat respiratory neurons to an adequate stimulus of the vestibular apparatus]. PMID- 4320406 TI - [Differences in the enzyme activity of abdominal cavity and lung macrophages]. PMID- 4320405 TI - [Interrelations of vestibular nuclei in the cat medulla oblongata]. PMID- 4320407 TI - [Interaction of carcinogens with microsomal blood proteins]. PMID- 4320408 TI - [New type of ESR signal arising in animal tissues treated with a series of chemical agents and during necroses]. PMID- 4320409 TI - [Number of rapid eye movements during human night sleep under different conditions]. PMID- 4320410 TI - [Effect of imidazole and its derivatives on the neurons of the gastropod Limnaea stagnalis]. PMID- 4320411 TI - [Distribution of electrotonic connections between neurons in the ganglia of the leech Hirudo medicinalis L]. PMID- 4320412 TI - Calcification of collagen by urine in vitro: dependence on the degree of saturation of urine with respect to brushite. AB - A state of supersaturation of urine with respect to brushite is considered to be important in the formation of renal stones composed of calcium phosphate. 56 supersaturated urine specimens and 44 undersaturated specimens were incubated with collagen (Sigma collagen). Most of the supersaturated specimens calcified the collagen, whereas none of the undersaturated ones did so. Among samples which calcified the collagen, whereas none of the undersaturated ones did so. Among samples which calcified the collagen, the activity product of Ca(++) and HPO(4) (=) after incubation with collagen was essentially the same as that after incubation of the same specimen with brushite; it usually differed from that obtained after incubation with octacalcium phosphate or hydroxyapatite. The molar calcium-to-phosphorus ratio of the solid phase in collagen was approximately 1. These results suggested that the solid phase formed in collagen is brushite. This conclusion was confirmed by the direct identification of brushite in collagen by X-ray diffraction. PMID- 4320413 TI - Adrenocortical function in the horse. PMID- 4320414 TI - 6-oxygenated progesterone metabolites and the regulation of steroidogenesis in late human pregnancy. PMID- 4320415 TI - Another case of split-foot mutation in two sibs. PMID- 4320416 TI - Dissection and chemical analysis of substructures of the organ of Corti. PMID- 4320417 TI - Viral-induced mutagenesis: tests in Gallus domesticus. PMID- 4320418 TI - Testicular calcification in a 4-year-old boy. PMID- 4320419 TI - The treatment of cyanide poisoning in children. PMID- 4320420 TI - The histopathology of the temporal bone in tumours of the glomus jugulare. PMID- 4320421 TI - Roentgen features of healing and healed benign gastric ulcers. PMID- 4320422 TI - The angiographic evaluation of gallbladder dilatation. PMID- 4320423 TI - A case of segmental resection of primary duodenal carcinoma. PMID- 4320424 TI - Pituitary disease. PMID- 4320425 TI - [Ultrastructural localization of cytochrome oxidase in the mitochondria of normal guinea pig epidermis]. PMID- 4320426 TI - The structure of the nicotinamide-adenine dinucleotide coenzyme when bound to lactate dehydrogenase. PMID- 4320427 TI - Interaction of lactate dehydrogenase with its coenzyme, nicotinamide-adenine dinucleotide. PMID- 4320428 TI - [Arterial hypertension in the course of corticosteroid treatment of the nephrotic syndrome]. PMID- 4320429 TI - [Invalids under Social Security with nervous system diseases in a city population]. PMID- 4320430 TI - Adenocystic carcinoma of the palate. PMID- 4320431 TI - Density-dependent inhibition of protein synthesis in normal and virus-transformed cells. PMID- 4320432 TI - [Isolation and examination of inclusion-bodies of the rat-kidney after chronic lead poisoning]. PMID- 4320433 TI - [Histo- and biochemical investigations on the degradation of Liiodol Ultrafluid in the human lymph node]. PMID- 4320434 TI - [Serum phosphatases in gynecologic surgical cases]. PMID- 4320435 TI - The cytochrome c-catalysed oxidation of ascorbate in the presence of sodium dodecyl sulphate and NNN'N'-tetramethyl-p-phenylenediamine. PMID- 4320436 TI - Thermodynamics of phosphate transfer in the phosphoglucomutase system. PMID- 4320437 TI - Structures of the naturally occurring hydroxamic acids, fusarinines A and B. PMID- 4320438 TI - On the mechanism of action of antibiotic U-19,718 in rat liver mitochondria. PMID- 4320439 TI - Isolation and identification of 5-hydroxy-4-ketovaleric acid as a product of alpha-ketoglutarate: glyoxylate carboligase. PMID- 4320440 TI - Metabolism of ethylmalic acids by Pseudomonas aeruginosa. PMID- 4320441 TI - Purification and comparative properties of human lactate dehydrogenase isozymes from uterus, uterine myoma, and cervical cancer. PMID- 4320442 TI - Potentiation of viral carcinogenesis by immunosuppression. PMID- 4320443 TI - [Study of Ciperus esculentus amino acids with regard to its value in weaning food]. PMID- 4320444 TI - An automated system for kinetic multiple-point determinations exemplified by serum lactic dehydrogenase determination. PMID- 4320445 TI - Effects of Escherichia coli and Clostridium perfringens on pathogen-free, 1-day old, fasting pigs. PMID- 4320446 TI - Hydrocortisone determination in bovine plasma. PMID- 4320448 TI - [A case of pulmonary adenomatosis]. PMID- 4320447 TI - Peroxidase-mediated antimicrobial activity of rat uterine fluid. PMID- 4320449 TI - Evidence for a linear correlation between the level of dietary tryptophan and hepatic NAD concentration and for a systematic variation in tissue NAD concentration in the mouse and the rat. PMID- 4320450 TI - A microbiological and biochemical study of gingival crevice debris obtained from Guatemalan Mayan Indians. PMID- 4320451 TI - Cardiovascular effects of atelopidtoxin. PMID- 4320452 TI - Muscle membrane depolarization by acetylcholine, choline and carbamylcholine, near and remote from motor end-plates. PMID- 4320453 TI - Stimulation of RNA synthesis in the blastocyst and uterus of the rat by adenosine 3'5'-monophosphate (cyclic ApMP). PMID- 4320454 TI - The alterations of protein metabolism of the brain cortex induced by anticipation stress and ACTH. PMID- 4320456 TI - [Dissociation of function and metabolism of the isolated guinea pig heart under the influence of phosphodiesterase inhibitors]. PMID- 4320455 TI - Inhibition of cyclic-3',5'-nucleotide-phosphodiesterase as a possible mode of action of papaverine and similarly acting drugs. PMID- 4320457 TI - [Relations between RNA molecular structure and their induction power on interferon]. PMID- 4320458 TI - [Animal viral anemia: equine infectious anemia]. PMID- 4320459 TI - [Adrenal insufficiency after prolonged corticosteroid therapy. Biological study of 22 cases]. PMID- 4320460 TI - [Polygraphic study of night sleep under hexapropymate]. PMID- 4320461 TI - Mechanism of activation of catabolite-sensitive genes: a positive control system. AB - Catabolite repression is defined as the inhibition of enzyme induction by glucose or related substances. In the bacterium E. coli, the effect of glucose appears to be due to a lowering of the cyclic AMP level. A DNA-directed cell-free system for beta-galactosidase synthesis has served as a model system for studying the mechanism of action of cyclic AMP. Previously, it was reported that in this system cyclic AMP is required for normal initiation of mRNA synthesis. A protein factor which acts in conjunction with the cyclic AMP has been partially purified. This protein factor has a high affinity for cyclic AMP. These and other results presented herein lead us to the conclusion that cyclic AMP and a protein factor called the catabolite gene activator protein are part of a positive control system for activating catabolite-sensitive genes. PMID- 4320463 TI - Adrenalectomy and the suppression of memory by puromycin. AB - It has previously been shown that expression of memory of maze-learning in mice is blocked by puromycin injected intracerebrally one or more days after the training experience. Bilateral adrenalectomy before training has now been found to protect memory against the effects of puromycin. This protection is absent when adrenalectomy follows training. In view of control experiments, we conclude that adrenalectomy before training modifies factors necessary for the expression of memory and that this alteration makes puromycin ineffective in blocking memory. PMID- 4320462 TI - Binding of adenosine 3':5'-cyclic phosphate to G factor of Escherichia coli, and its effects on GTPase, RNase V, and protein synthesis. AB - Unique among adenine nucleotides tested by filter binding assays, 3':5'-cyclic AMP binds to the G translocation factor. Binding is dependent on the presence of GTP, and is inhibited by GDP, by the analog 5'-beta,gamma-methylene GTP, and by the antibiotic fusidic acid. The cAMP seems to be released during the ribosome dependent translocation of charged tRNA catalyzed by G factor. Bound cAMP inhibits GTPase and ribosome-associated degradation of messenger RNA, but does not inhibit protein synthesis. cAMP might thereby regulate the ratio of productive to degradative transits of ribosomes on messenger RNA, and this may account for some part of its profound effect on levels of specific bacterial messenger RNA species. PMID- 4320464 TI - Glycosphingolipids of plasma membranes of cultured cells and an enveloped virus (SV5) grown in these cells. AB - Glycosphingolipids of rhesus monkey kidney (MK), bovine kidney (MDBK), and two lines of hamster kidney (BHK21-F and Hak) cells have been compared with those of parainfluenza (SV5) virions grow in these cells. There are qualitative and quantitative differences in the neutral glycolipids and gangliosides found in the various cells. Cells with a high neutral glycolipid content (MK and MDBK) contain little or no gangliosides, and those with a relatively high ganglioside content (BHK21-F and HaK) contain little neutral glycolipid. Glycosphingolipids are found predominantly in the plasma membranes. Neutral glycolipids of the host cell membrane are incorporated into the envelope of SV5 virions, but neither gangliosides nor protein-bound neuraminic acid are found in virions. The absence of neuraminic acid from the virion may be due to the action of viral neuraminidase. PMID- 4320465 TI - [Dynamic explorations of ACTH secretion]. PMID- 4320466 TI - [Verner-Morrison syndrome with non-tumoral form. A case]. PMID- 4320467 TI - Adenyl cyclase of cultured mammalian cells: activation by catecholamines. AB - Chang's liver cells and 3T6 mouse embryo fibroblasts contain high amounts of catecholamine-sensitive adenyl cyclase, whereas HeLa cells contain relatively low amounts of activity. Both epinephrine and fluoride ion stimulate activity of each cell line. In contrast to normal liver, Chang's liver cells show greater response to epinephrine and no detectable stimulation by glucagon. PMID- 4320468 TI - [Circumferential ulcer of the cardia causing esophago-gastric stenosis]. PMID- 4320469 TI - [Ulcer of the neck on a hiatal hernia]. PMID- 4320470 TI - [Recurrent and strangulated hiatal hernia]. PMID- 4320471 TI - [2 cases of benign tumors of the cardia]. PMID- 4320472 TI - [False benign tumor of the upper pole of the stomach. Value of arteriography for diagnosis and treatment]. PMID- 4320473 TI - [Postoperative gastro-jejunal ulcer in a woman previously vagotomised for duodenal ulcer]. PMID- 4320474 TI - [Cancer of the gastric antrum. 13 year development]. PMID- 4320475 TI - [2 cases of pyloric cancer in a young patient]. PMID- 4320476 TI - [False benign duodenal tumor (an apricot stone)]. PMID- 4320477 TI - [Duodenal adenocarcinoma of pseudo-ulcerous form]. PMID- 4320478 TI - [Double duodenal and ileal biliary ileus]. PMID- 4320479 TI - [Nonspecific ileo-cecal inflammatory lesion]. PMID- 4320480 TI - [Ileal and ileo-cecal stenosis due to retro-cecal appenditis]. PMID- 4320481 TI - [Unrecognized ileal cancer]. PMID- 4320482 TI - [A case of colonic Crohn's disease with pyelo-ureteral effect in an adolescent]. PMID- 4320483 TI - [Latent cancer of the cecum revealed by acute appendicitis of occlusive form]. PMID- 4320484 TI - [Cancer of the left colonic flexure, fistulised into the bronchi, 6 years after a double cecal and sigmoid neoplastic localization]. PMID- 4320485 TI - [Villous tumor of the recto-sigmoid junction. Value of radiologic study by oblique rays]. PMID- 4320486 TI - [Cyst of the common bile duct]. PMID- 4320487 TI - [Lithiasis of the choledochus secondary to a chronic primary pancreatitis]. PMID- 4320488 TI - [Intra-hepatic biliary lithiasis after hepatico-jejunal anastomosis]. PMID- 4320489 TI - [Obstructive jaundice following a fistulization of hydatid cyst into the bile ducts]. PMID- 4320490 TI - [Jaundice due to choledochal necrosis during acute pancreatitis]. PMID- 4320491 TI - [Traumatic retroperitoneal tumor?]. PMID- 4320492 TI - [Cranio-chordal dysplasia (basilar impression and manifestation of the occipital vertebra) in a sibship with other forms of axial, appendicular and facial dysplasia]. PMID- 4320493 TI - [Radiological study of the localizations of vertebral hyperostosis at the level of the cervico-occipital hinge]. PMID- 4320494 TI - [Measurement of the sagittal diameter of the cervical canal in adults]. PMID- 4320495 TI - [Cervical forms of vertebral hyperostosis]. PMID- 4320496 TI - [Cystic and diverticular formations of the spinal meninges]. PMID- 4320497 TI - Bacterial enterotoxins and diarrhea. PMID- 4320499 TI - Benign lymphoepithelial lesion of the parotid gland associated with cytomegaly. PMID- 4320498 TI - New episodes of fever in hospitalized children. PMID- 4320500 TI - Wilms' tumor prior to onset of hemihypertrophy. PMID- 4320501 TI - [Study of the action of some new analogues of cyclic AMP on the release of growth hormone and prolactin in vitro]. PMID- 4320502 TI - [Calculation and experimental realization of active transport of neutral molecules in vitro, with structured, multi-layer, bi-enzymatic, sequential membranes]. PMID- 4320503 TI - Sequential adrenal and ovarian suppression tests in the differential diagnosis of the polycystic ovary (Stein-Leventhal) syndrome. PMID- 4320504 TI - [Influence of biophysical factors upon the oxidation-reduction processes and biologic oxidation. 10. ACTH level in serum after application of ultrasonics]. PMID- 4320505 TI - [Treatment of infectious hepatitis with glucocorticoids]. PMID- 4320506 TI - [Bacterial content of the extirpated appendix and extirpated gallbladder following directed antibiotic therapy]. PMID- 4320508 TI - Cushing's syndrome in the dog. PMID- 4320507 TI - [Pharmacokinetics and clinical therapy with carbenicillin]. PMID- 4320509 TI - [Role of arterial pressure variations in the renal response to angiotensin (experimental study)]. PMID- 4320510 TI - Catalytic mechanism of cytochrome oxidase. PMID- 4320511 TI - Reversion of virus-transformed cell lines: hyperploidy accompanies retention of viral genes. PMID- 4320512 TI - Effect of L-dopa on the sleep of man. PMID- 4320513 TI - In vivo studies on the mechanism of action of 6-dehydro-16-methylene hydrocortisone (STC 407) on the hypothalamo-pituitary-adrenal axis in rats. PMID- 4320514 TI - Effect of acute and prolonged electrical stimulation of the amygdala of the dog upon peripheral plasma concentrations of corticosteroids. PMID- 4320515 TI - [Embryonal tumors of the retroperitoneal space and small pelvis in children]. PMID- 4320516 TI - [Processes of acetylization and glucocorticoid function of the adrenal glands in children with bronchial asthma]. PMID- 4320517 TI - Immunoglobuln synthesis after immunization with human wart virus. PMID- 4320518 TI - Studies on the neutralization of poliovirus by fecal immunoglobulins. The development of intestinal IgA antibodies following oral poliovirus immunization. PMID- 4320519 TI - Mechanisms of oral immunization with inactivated microorganisms. PMID- 4320520 TI - [Importance of cell cultures for the study of primary stimulation]. PMID- 4320522 TI - Some problems of standardization of attenuated poliovirus titration techniques. PMID- 4320521 TI - Immunochemical investigations on the antigenic structure of heat resistant "Cl. perfringens" type A strains. PMID- 4320523 TI - The role of the defensive mechanism in experimental poliomyelitis. PMID- 4320525 TI - [Adrenocortical function in the course of human trichinosis]. PMID- 4320524 TI - [Dissemination of the vaccine poliomyelitis virus in the families of vaccinated children]. PMID- 4320526 TI - [ACTH or glucocorticoids]. PMID- 4320527 TI - Regulation of ATP citrate lyase activity in vitro. PMID- 4320528 TI - Effect of amyl azide on respiration and oxidative phosphorylation in mitochondria. PMID- 4320530 TI - [Regarding some new possibilities of treatment in trophoblastic diseases. Report of our cases]. PMID- 4320529 TI - [Value of angiography in the diagnosis of renal tumors]. PMID- 4320531 TI - Acinic cell adenocarcinoma of the parotid with ectopic production of adrenocorticotropic hormone. PMID- 4320532 TI - Clinical and bacteriologic evaluation of gentamicin ophthalmic preparations. PMID- 4320533 TI - Quso G32 extraction of labeled peptide hormones. PMID- 4320534 TI - On the mechanism of fructose 1,6-diphosphatase: inhibition by methyl D-fructoside 1,6-diphosphate. PMID- 4320535 TI - Peripheral neuropathy in Cockayne's syndrome. PMID- 4320537 TI - Resurgence of two fetal-type of aldolases (A and C) in some fast-growing hepatomas. PMID- 4320538 TI - Yeast uridine diphosphate galactose 4-epimerase coenzyme complexes. Fluorescence and energy transfer. PMID- 4320539 TI - Use of isotope competition and alternative substrates for studying the kinetic mechanism of enzyme action. I. Experiments with hexokinase and alcohol dehydroeenase. PMID- 4320540 TI - Electron paramagnetic resonance studies of spin-labeled hemoglobins. II. Roles of subunit interactions and of intermediate structures in the cooperative oxygenation of hemoglobin and the results of hemoglobin Yakima, hemoglobin J capetown, and carboxypeptidases A and B treated hemoglobin A. PMID- 4320541 TI - Studies on the mechanism of ribonucleic acid synthesis. II. Stabilization of the deoxyribonucleic acid-ribonucleic acid polymerase complex by the formation of a single phosphodiester bond. PMID- 4320542 TI - Effect of protein kinase on ribonucleic acid polymerase. PMID- 4320544 TI - Stoichiometry of yeast nucleotidyl transferase and effect on the addition reactions of stepwise removal of nucleotides from the acceptor aend of the transfer ribonucleic acid. PMID- 4320543 TI - Purification and characterization of yeast nucleotidyl transferase and investigation of enzyme-transfer ribonucleic acid complex formation. PMID- 4320545 TI - Enzymatic adaptations in newborn pig liver. PMID- 4320546 TI - Wilms's tumor: the experience at the I. Gonzalez Martinez Hospital. PMID- 4320547 TI - [Hypertensive activity in protein extracts of swine placenta]. PMID- 4320548 TI - A circulatory collagenase inhibitor. PMID- 4320549 TI - Clinical electromyography. A review. PMID- 4320550 TI - [Glomus tumors. Case report and electron microscopy findings]. PMID- 4320552 TI - [Orbital phlebography]. PMID- 4320551 TI - Reactivity of radioiodinated serum antibody from Burkitt's lymphoma and nasopharyngeal carcinoma patients against culture lines derived from Bukrkitt's lymphoma. PMID- 4320553 TI - Effect of Neocarzinostatin on the cultured Burkitt lymphoma cells, with particular reference to the enhancement of production of Epstein-Barr virus. PMID- 4320554 TI - Mechanism of thyroid-stimulating hormone action. Studies with dibutyl 3',5' adenosine monophosphate and lecithinase C. PMID- 4320555 TI - [Inhibition by N-ethylmaleimide of the epinephrine-induced phosphorylase and lipolysis activation]. PMID- 4320556 TI - On the biological role of cyclic AMP. PMID- 4320557 TI - [Significance of isoniazid for the therapy of experimental infection with total INH- and SM- resistant human tuberculosis bacteria in the mice]. PMID- 4320559 TI - [Neurologic manifestations in insulinoma]. PMID- 4320558 TI - The influence of caffeine on endogenous cyclic 3',5' -AMP and uterine smooth muscle contraction induced by oxytocin. PMID- 4320560 TI - [On the therapy of myasthenia gravis. (Presentation of a case)]. PMID- 4320561 TI - [Clinical and anatomopathological study of grave forms of adenovirus infections in childhood]. PMID- 4320563 TI - Viral DNA-dependent DNA polymerase and the properties of thymidine labelled material in virions of an oncogenic RNA virus. PMID- 4320562 TI - A DNA-depenent DNA polymerase and a DNA endonuclease in virions of Rous sarcoma virus. PMID- 4320564 TI - Synthetic DNA-RNA hybrids and RNA-RNA duplexes as templates for the polymerases of the oncogenic RNA viruses. PMID- 4320565 TI - DNA polymerases of Rous sarcoma virus: delineation of two reactions with actinomycin. PMID- 4320566 TI - Separation of RNA-dependent DNA polymerase activity from the murine leukaemia virion. PMID- 4320567 TI - Sarcoma blockade in vivo. Rabies-Rous system in chickens. PMID- 4320568 TI - [Influence of hormones on the osmotic resistance of leukocytes]. PMID- 4320569 TI - [Hypoglycemic tumors of the pancreas. Diagnosis, treatment and results]. PMID- 4320570 TI - Biologic activity of isolated viral nucleic acids. PMID- 4320571 TI - Viruses and chromosomes. PMID- 4320572 TI - The effect of cyclic AMP and related compounds on human lymphocyte transformation (HLT) stimulated by phytohemagglutinin (PHA). PMID- 4320573 TI - [Enzyme study of 21 cases of glycogenosis]. PMID- 4320574 TI - [Para-sleep and autonomic nervous system]. PMID- 4320575 TI - [Activity of the limbio-hypothalamic system in the process of adaptation and repeated stress]. PMID- 4320576 TI - [Diffuse metastatic leptomeningeal carcinomatosis. Report of a case secondary to bronchiolo-alveolar carcinoma and a review of 93 cases in Japan]. PMID- 4320577 TI - Supporting tissue neoplasms of the larynx. PMID- 4320578 TI - Mammary tumorigenesis in splenectomized mice. PMID- 4320579 TI - Studies on FBJ virus-induced bone tumors in mice. PMID- 4320580 TI - Interactions between sensitized lymphoid cells and adenovirus-12-induced tumor cells. PMID- 4320581 TI - Paramagnetic labeling studies. 1. A new method for labeling proteins with a stable paramagnetic nitroxide radical. PMID- 4320582 TI - Cleavage of cardiac glycosides in organic media. PMID- 4320583 TI - [Metabolic behavior of a rat tumor associated with chick embryo mesonephros in organotypic culture. I. Histochemical study]. PMID- 4320584 TI - Histochemical observations of monoamine oxidase activity in human tumors. PMID- 4320585 TI - Oxidation-reduction potentials of cytochromes in mitochondria. PMID- 4320586 TI - Sialic acid transferases and sialic acid levels in normal and transformed cells. PMID- 4320587 TI - [Temperature quenching of the triplet state in a series of porphyrins. II. Contribution of the photochemical reaction]. PMID- 4320588 TI - [Spectral study of the photochemistry of flavin adsorbates. I. Adsorption on aerosil]. PMID- 4320589 TI - [Nature of a new type of EPR signal observed in neoplastic tissues]. PMID- 4320590 TI - [Free radicals in liver and brain tissue of white rats following injection of varying doses of thyroxine and at different periods after thyroidectomy]. PMID- 4320591 TI - [EPR study of dark and photochemical reactions of tetrapyrrole pigments with negative molecular ions in solution]. PMID- 4320592 TI - [Induction of new and specific puffs by perchlorates]. PMID- 4320593 TI - [E.P.R. spectra of a gamma-irradiated monocrystal of lysozyme chloride]. PMID- 4320594 TI - Inhibition of bone resorption by acetazolamide in the rat. PMID- 4320595 TI - In vitro effects of ACTH, angiotensins, serotonin and potassium on steroid output and conversion of corticosterone to aldosterone by isolated adrenal cells. PMID- 4320597 TI - Protamine-induced hypocalcemia. PMID- 4320596 TI - Inhibition by theophylline of the stimulatory effects of growth hormone on amino acid transport and protein synthesis in muscle. PMID- 4320598 TI - Urinary bladder of leopard frogs (Rana pipiens): effects of vasotocin, cyclic AMP, cyclic GMP and aldosterone. PMID- 4320599 TI - Follicular processes in ovulation. PMID- 4320600 TI - Neurohormonal correlates of ovulation. PMID- 4320601 TI - Metabolism of adult and embryonic sympathetic ganglia. PMID- 4320602 TI - Catecholamine fluorescence studies of adrenergic neurons and chromaffin cells in sympathetic ganglia. PMID- 4320603 TI - Generation of slow inhibitory and excitatory postsynaptic potentials. PMID- 4320604 TI - Pharmacologic considerations in the analysis of synaptic function: an hypothesis concerning the initiation of the synaptic potential. PMID- 4320605 TI - [Metabolism of glucuronic acid. 21. Effects of nucleic acids on activities of several enzymes associated with formation of glucuronide under administration of borneol in the Gunn rat]. PMID- 4320606 TI - Magnetic resonance studies of manganese (II) binding sites of pyruvate kinase. Temperature effects and frequency dependence of proton relaxation rates of water. PMID- 4320607 TI - The mechanism of 6-deoxyhexose synthesis. V. The relation of pyridine nucleotide to the structure of the deoxythymidine diphosphate-glucose oxidoreductase. PMID- 4320608 TI - Conformational states of rabbit liver fructose 1,6-diphosphatase. PMID- 4320609 TI - Carbamyl phosphate synthesis in a land snail, Strophocheilus oblongus. PMID- 4320610 TI - Control of phosphorylase activity in a muscle glycogen particle. I. Isolation and characterization of the protein-glycogen complex. PMID- 4320611 TI - Control of phosphorylase activity in a muscle glycogen particle. II. Activation by calcium. PMID- 4320613 TI - Molecular weight of two states of cytochrome c oxidase. PMID- 4320612 TI - Control of phosphorylase activity in a muscle glycogen particle. 3. Regulation of phosphorylase phosphatase. PMID- 4320614 TI - Absorption spectra and enzymatic properties of monomer and dimer states of cytochrome c oxidase. PMID- 4320615 TI - Corticosteroid crystals in synovial fluid. PMID- 4320616 TI - Serratia marcescens. Biochemical characteristics, antibiotic susceptibility patterns, and clinical significance. PMID- 4320617 TI - Isolation of different kinds of non-virus producing chick cells transformed by Schmidt-Ruppin strain (subgroup A) of Rous sarcoma virus. PMID- 4320618 TI - The measurement of serum 11-hydroxycorticosteroids in the diagnosis of adrenal cortical disease. PMID- 4320620 TI - [Technical details for the re-evaluation of the trans-nasal sphenoidal approach in the surgical treatment of adenomas of the hypophysis]. PMID- 4320619 TI - [On thanatology of the lung in poisoning with organic phosphate esters (TEPP)]. PMID- 4320621 TI - [On the angiographic diagnosis of neoplasms of the corpus callosum]. PMID- 4320622 TI - [On 6cases of glioblastomas of the cerebral hemisphere with long survival]. PMID- 4320623 TI - [Method for the prevention of intolerance to organic iodinated contrast media]. PMID- 4320624 TI - [Vitamin D deficiency rachitis]. PMID- 4320625 TI - [Pseudomonas aeruginosa infections]. PMID- 4320626 TI - [Studies on the composition and carcinogenic properties of substances contained in dust suspended in atmospheric air. II. Studies on carcinogenic properties of benzene extracts from the atmospheric dust collected in 10 towns in Poland]. PMID- 4320627 TI - [Epidemiology of asphyxia due to gas. Methodological remarks]. PMID- 4320628 TI - [Public health policy. Smallpox vaccination in the USA, and measles vaccination in Senegal]. PMID- 4320629 TI - [Acute terminal transformation of chronic lymphatic leukemia]. PMID- 4320630 TI - [Pathologic effects of U.H.F. electromagnetic radiation from Aeriens radar. A case report]. PMID- 4320631 TI - [Micromethod for the determination of plasma renin activity (P.R.A.) in rats and its use in the study of the role of P.R.A]. PMID- 4320632 TI - [Could angiotensin have a vasodilator action?]. PMID- 4320633 TI - [ Secondary hyperaldosteronism]. PMID- 4320634 TI - [Cytopathogenic and transforming effect of infectious and oncogenic viruses in tissue culture]. PMID- 4320635 TI - [Structure of the respiratory neuron system of the medulla oblongata]. PMID- 4320636 TI - Induction of uterine phosphofructokinase by cyclic 3',5'-adenosine monophosphate. PMID- 4320637 TI - Metabolism of phospholipids, neutral lipids and carbohydrates in dispersed porcine thyroid cells: comparative effects of pituitary thyrotropin and dibutyryl 3',5'-adenosine monophosphate on the turnover of slices from pig thyroid. PMID- 4320638 TI - Dopamine-beta-hydroxylase activity in the rat after hypophysectomy. PMID- 4320639 TI - Adrenal cells in tissue culture. VII. The effect of inhibitors of protein synthesis on steroidogenesis and glycolysis. PMID- 4320640 TI - Interruption of implantation and gestation in rats by reserpine, chlorpromazine and ACTH: possible mode of action. PMID- 4320641 TI - Crisis unresolved. PMID- 4320642 TI - The contribution of plasma dehydroepiandrosterone sulfate to testosterone in a virilized patient with an arrhenoblastoma. PMID- 4320643 TI - The frequency of sleep talking in the laboratory among chronic sleep talkers and good dream recallers. PMID- 4320644 TI - The degree of concordance between the content of sleep talking and mentation recalled in wakefulness. PMID- 4320645 TI - The localization of 5-hydroxytryptamine and its participation in neural inhibition of gastrointestinal smooth muscle. PMID- 4320646 TI - Interpretation of the electromyogram of the small intestine as recorded with external electrodes. PMID- 4320647 TI - [Studies of the effect of cortisone upon the susceptibility of mice to herpesvirus infection]. PMID- 4320648 TI - [Poisoning and infection from food]. PMID- 4320649 TI - [Introduction to the symposium on the anti-inflammatory and immunosuppressive therapy of some glomerular nephropathies]. PMID- 4320650 TI - [A complex surgical reconstruction of ocular congenital malformations (cryptophthalmos, hypoplasia of the eyelid and of the erratic eyebrow) associated with development of abnormalities of the external ear and syndactylia]. PMID- 4320651 TI - Changes in pathogenicity of equine infectious anemia virus during passages in horse leukocyte cultures. PMID- 4320652 TI - Immunization of horses against equine infectious anemia (EIA) with an attenuated EIA virus. PMID- 4320653 TI - Nature of complement-fixing antibodies in horses infected with equine rhinopneumonitis virus. PMID- 4320655 TI - Viruses and Burkitt's lymphoma. PMID- 4320654 TI - Potentiating-factor dependency and molecular size of neutralizing antibodies produced in bovine parainfluenza 3 virus infection. PMID- 4320656 TI - Epstein-Barr virus in Burkitt's lymphoma and nasopharyngeal carcinoma. Antibodies to EBV associated membrane and viral capsid antigens in Burkitt lymphoma patients. PMID- 4320657 TI - EBV DNA in biopsies of Burkitt tumours and anaplastic carcinomas of the nasopharynx. PMID- 4320659 TI - [Metabolic function of cytochrome P-450]. PMID- 4320658 TI - [After care of female genital and breast cancer]. PMID- 4320660 TI - [Compensatory changes in the remaining kidney after unilateral nephrectomy]. PMID- 4320661 TI - Nervous transmission in the superior cervical ganglion of the thiamine-deficient rat. PMID- 4320662 TI - [Toxicity of iodine containing contrast media with special consideration of local reactions]. PMID- 4320663 TI - [Compatibility of water-soluble contrast media containing iodine from the view point of roentgenology and hematology]. PMID- 4320664 TI - [Contrast media used in lymphography]. PMID- 4320665 TI - Neuropathy of the sympathetic nervous system associated with diabetes mellitus. PMID- 4320666 TI - [Beta 1-24 corticotrophin or tetracosactide in asthma and allergic diseases]. PMID- 4320667 TI - Induction of SV40 transplantation antigen (TrAg) during the lytic cycle. PMID- 4320668 TI - Replication of vesicular stomatitis virus. I. Viral specific RNA and nucleoprotein in infected L cells. PMID- 4320669 TI - Complementarity between Rous sarcoma virus (RSV) RNA and the in vitro-synthesized DNA of the virus-associated DNA polymerase. PMID- 4320670 TI - Stimulation or inhibition of interferon production depending on time of cycloheximide administration. PMID- 4320671 TI - [Successive multiple immunization with adenoviruses]. PMID- 4320672 TI - [Action of the spleen on excitation level of the brain. 2. Correlation between the spleen and hypophyseal-adrenocortical hormones on fluctuation of the excitation level of the brain of the rabbit]. PMID- 4320673 TI - [Congenital hip dislocation]. PMID- 4320674 TI - Hypothalamic releasing factors. PMID- 4320675 TI - Oncogenic viruses. PMID- 4320676 TI - Comparison of coil and Kiil dialysers. AB - To assess the comparative efficiency, safety, and cost of maintenance dialysis, the treatment of 13 patients with a Kiil dialyser (representing 1,477 hospital and 735 home dialyses) was compared with that of 11 patients using a coil dialyser (898 hospital and 396 home dialyses). Kiil and coil dialysers proved equally satisfactory from a medical standpoint and equally acceptable to the patients. The capital costs of home dialysis were considerably reduced without any threat to safety or efficiency. The running costs of coil dialysers approximate to those of Kiil dialysers. PMID- 4320677 TI - [Cell chromatolysis as pertaining to malignant neoplasms]. PMID- 4320679 TI - Evening activity, sleep mentation, and subjective sleep quality. PMID- 4320678 TI - Relationships between morphological changes and content of silica and hydroxyproline in bronchi and lungs of coal miners. PMID- 4320680 TI - Conscious control of dreaming. I. The posthypnotic dream. PMID- 4320682 TI - The role of 5-hydroxytryptamine and cyclic AMP in the control of fluid secretion by isolated salivary glands. PMID- 4320681 TI - A fluorimetric and enzymatic method for the estimation of serum total bile acids. AB - The enzymatic technique using 3alpha-hydroxysteroid dehydrogenase for determining bile acids in blood has been modified by measuring the reduced nicotinamide adenine dinucleotide fluorimetrically. The increased sensitivity attained enables the concentration of total bile acids in serum to be estimated using 3 ml for normal subjects and 1 ml for jaundiced patients. The range of normal values in serum was found to be 0-4.7 mumol/litre for males and 1.0-8.2 mumol/litre for females. PMID- 4320683 TI - Envelope antigen relationships among three hamster-specific sarcoma viruses and a hamster-specific helper virus. PMID- 4320685 TI - The influence of ultraviolet-inactivated Sendai virus on Marek's disease virus infection in tissue culture. PMID- 4320684 TI - Immunological identity of the group-specific antigen of hamster-specific C-type viruses and an indigenous hamster virus. PMID- 4320686 TI - Inhibitory effect of ultraviolet-inactivated vesicular stomatitis virus on initiation o DNA synthesis in cultured chick embryo cells. PMID- 4320687 TI - Coiled structure of the nucleocapsid of avian myeloblastosis virus. PMID- 4320689 TI - Sensitivity to inactivation by ultraviolet light of certain functions of polyoma virus: cell surface antigen. PMID- 4320688 TI - Interference with cell viability and poliovirus multiplication by polyinosinic- polycytidylic acid. PMID- 4320690 TI - Effect of interferon on the replication of Sendai virus. PMID- 4320692 TI - Chemodectoma of larynx. PMID- 4320693 TI - Observations on the epidemiology and control of viral respiratory disease in cats. PMID- 4320691 TI - Haemodynamic changes in women taking oral contraceptives. PMID- 4320694 TI - Mafenide hydrochloride and mafenide acetate in spray and ointment forms as topical therapy of C. perfringens contaminated massive wounds: experimental study. PMID- 4320695 TI - Formation of cellular deoxyribonucleic acid during productive polyoma virus infection. AB - It was previously shown that the majority of deoxyribonucleic acid (DNA) made in growing mouse embryo cells productively infected at low multiplicity with polyoma virus is cellular in nature and that some of this cell DNA contains discontinuities in the newly synthesized strand. Evidence obtained indicates the following. (i) Induction of cell DNA synthesis precedes the onset of detectable viral DNA replication by approximately 3 hr. (ii) Double-stranded cell DNA molecules, discontinuous in the newly synthesized strands, arise by direct synthesis (rather than by degradation of a high-molecular-weight precursor) only in the cell DNA replicated after initiation of viral DNA synthesis. (iii) This DNA component is continuously formed throughout the "late" stage of infection and is continuously converted into apparently normal cell DNA of high molecular weight without prior degradation to acid-soluble components. PMID- 4320696 TI - Deoxyribonucleic acid polymerase associated with Rous sarcoma virus and avian myeloblastosis virus: properties of the enzyme and its product. AB - Deoxyribonucleic acid (DNA) polymerase activity can be elicited in purified preparations of avian myeloblastosis virus and Rous sarcoma virus (Schmidt-Ruppin strain) by treatment with nonionic detergent. The enzyme(s) and its synthetic products appear to be virion-associated. Enzymatic activity can be inhibited by pretreatment with either ribonuclease (8- to 10-fold inhibition) or actinomycin D (twofold inhibition). By contrast, rifampin has little, if any effect. The enzyme(s) synthesizes two primary products, a ribonucleic acid (RNA):DNA hybrid and DNA which is free of RNA. The results of both zonal and equilibrium centrifugation indicate that nascent chains of DNA are associated with the 70S viral RNA. It is concluded that at least two enzymatic activities are under study: transcription of DNA from viral RNA, and subsequent, additional synthesis of DNA, utilizing product of the initial reaction as template. PMID- 4320697 TI - Isolation and properties of poliovirus minus strand ribonucleic acid. AB - Poliovirus minus strands were purified from double-stranded polio ribonucleic acid. The minus strands have a base ratio complementary to that of the viral ribonucleic acid and are not infectious. PMID- 4320698 TI - Transformation of mouse macrophages by simian virus 40. AB - Studies were undertaken to prove that simian virus 40 (SV40) can transform the mouse macrophage, a cell type naturally restricted from deoxyribonucleic acid (DNA) replication. Balb/C macrophages infected with SV40 demonstrated T-antigen production and induced DNA synthesis simultaneously. In the absence of apparent division, these cells remained T antigen-positive for at least 45 days. SV40 could be rescued from nondividing, unaltered macrophages during the T antigen producing period. Proliferating transformants appeared at an average of 66 days post-SV40 infection. Established cell lines were T antigen-positive and were negative for infectious virus, but yielded SV40 after fusion with African green monkey kidney cells. Their identity as transformed macrophages was substantiated by evaluation of cellular morphology, phagocytosis, acid phosphatase, beta(1c) synthesis, and aminoacridine incorporation. PMID- 4320700 TI - Simian virus 40 deoxyribonucleic acid transcription in vitro: binding and transcription patterns with a mammalian ribonucleic acid polymerase. AB - The in vitro transcription pattern of simian virus 40 (SV40) deoxyribonucleic acid (DNA) by a mammalian ribonucleic acid (RNA) polymerase, was studied by electron microscopy and velocity sedimentation techniques. It was found that (i) the majority of supercoiled SV40 DNA molecules displayed a single binding site for the enzyme, (ii) the supercoiled structure of SV40 DNA was frequently retained during transcription, and (iii) the majority of RNA molecules synthesized from the supercoiled SV40 DNA template showed no self-complementarity and sedimented relatively homogeneously in the 15S to 16S region of a sucrose gradient (in contrast, the RNA product synthesized from the nicked-circular SV40 DNA template showed self-complementarity and sedimented heterogeneously). RNA polymerase preparations isolated from SV40-infected monkey cells were more active than those isolated from uninfected monkey cells. PMID- 4320699 TI - Superinfection of simian virus 40-transformed permissive cells with simian virus 40. AB - Evidence that the resistance of simian virus (SV40)-transformed permissive cells to superinfection with SV40 is due to lack of virus uptake is presented. When virus uptake is enhanced, the events of infection proceed as in normal permissive cells, resulting in production of infectious virus. PMID- 4320702 TI - Proteins of avian tumor viruses with different coat antigens. AB - Isoelectric focusing of avian tumor viruses with distinct type-specific envelope antigens demonstrated no differences in isoelectric points. Viruses with different type-specific antigens were found to contain different glycoprotein components when virion proteins were separated by sodium dodecyl sulfate polyacrylamide gel electrophoresis. PMID- 4320703 TI - Epstein-Barr viral antigen in single cell clones of two human leukocytic lines. AB - A method was devised for obtaining single cell clones of human leukocytic cell lines in the presence of a human placental cell feeder layer. Clones of two lines, LS-B and EB(3), which contain Epstein-Barr viral (EBV) antigen in approximately 1% of cells were tested for EBV antigen. Since all EB(3) clones and LS-B clones contained EBV antigen, it is concluded that in vitro EBV genome is associated with all of the cells. PMID- 4320701 TI - Nucleocapsid protein subunits of simian virus 5, Newcastle disease virus, and Sendai virus. AB - Helical nucleocapsids of each of the paramyxoviruses simian virus 5 (SV5), Newcastle disease virus (NDV), and Sendai virus have been isolated in two different forms. One form contains larger protein subunits and is obtained from mature virions or infected cells dispersed by ethylenediaminetetraacetic acid. The other form possesses smaller subunits and is obtained from infected cells dispersed by trypsin. The estimated molecular weights of the larger subunits in the three viruses are similar: SV5, 61,000; Sendai virus, 60,000; NDV, 56,000. The smaller nucleocapsid subunits are also very similar: SV5, 43,000; Sendai virus, 46,000; NDV, 47,000. The helical nucleocapsid composed of the smaller subunit appears to be less flexible and more stable than that formed by the larger subunit. There is suggestive evidence that conversion of the larger subunit to the smaller by proteolytic cleavage may occur intracellularly. The possibility that such a mechanism could be involved in the accumulation of nucleocapsid in cells persistently infected with paramyxoviruses is discussed. PMID- 4320704 TI - New in psychiatry. Moditen injectable therapy and follow-up care. PMID- 4320705 TI - Canine cutaneous histiocytoma. A light and electron microscopic study. PMID- 4320706 TI - Androgens levels in plasma and urine of patients with virilizing congenital adrenal hyperplasia. PMID- 4320708 TI - Mixed mesodermal tumour of the ovary arising in pelvic endometriosis. PMID- 4320707 TI - A study of the parents of patients with congenital adrenal hyperplasia: detection of the heterozygote. PMID- 4320709 TI - Tumour development following immunosuppression. PMID- 4320710 TI - Animal experiments and the etiology of gas gangrene. PMID- 4320711 TI - [Dual functions of coat protein of small spherical viruses--particle fromation and regulation of biosynthesis]. PMID- 4320712 TI - [Glucan of yeast]. PMID- 4320713 TI - The differential diagnosis of viral skin infections of the bovine teat. PMID- 4320714 TI - Calcium dependent phosphodiesterase activity and its activating factor (PAF) from brain studies on cyclic 3',5'-nucleotide phosphodiesterase (3). PMID- 4320715 TI - Type VI glycogenosis: biochemical demonstration of liver phosphorylase deficiency. PMID- 4320717 TI - The oxidation-reduction potentials of the iron-sulfur proteins in mitochondria. PMID- 4320716 TI - Enzyme-bound phosphopantetheine in tyrocidine biosynthesis. PMID- 4320718 TI - Mode of action of adenosine 3',5'-cyclic phosphate on protein kinase from rat liver. PMID- 4320719 TI - Protein kinase activation and phosphorylation of a purified hormone-sensitive lipase. PMID- 4320720 TI - Infectivity of herpes simplex virus particles with and without envelopes. PMID- 4320721 TI - Epithelial-stromal junction of intraductal carcinoma of the breast. PMID- 4320723 TI - Histologic and ultrastructural features of adenoid cystic carcinoma of the breast. PMID- 4320722 TI - Breast cancer during oral contraceptive therapy. PMID- 4320724 TI - Osseous metastases in neuroblastoma. A 17-year survival. PMID- 4320725 TI - Retropharyngeal spread of carcinoma of the thyroid. PMID- 4320726 TI - [Problems in the treatment of cardiogenic shock]. PMID- 4320727 TI - [Clinical and morphologic peculiarities of infant hepatitis]. PMID- 4320728 TI - Structure and activity of corticotrophic peptides: synthesis and biological activity of two corticotrophic peptides with neutral amino acids in positions 17 and 18. PMID- 4320729 TI - [Action of some catechins on the activity of an enzyme (cytochrome oxidase) of the respiratory chain]. PMID- 4320730 TI - Production of cleft palate with dexamethasone and hypervitaminosis A in rat embryos. PMID- 4320731 TI - Cellular antigens in myxo- and paramyxoviruses as revealed by immunodiffusion methods. PMID- 4320733 TI - Twelve cases of rupture of hepatoma. PMID- 4320732 TI - Failure to stimulate significant cortisol or growth hormone secretion in man by ether infusion. PMID- 4320734 TI - Specificity of respiratory secretion antibody against influenza virus. PMID- 4320735 TI - Production of interferon in primary chick embryonic cells infected with Rickettsia mooseri. PMID- 4320736 TI - Neuronal linkage in cat visual cortex. PMID- 4320737 TI - Conduction velocity of optic nerve fibers and receptive field of lateral geniculate cells in the rat. PMID- 4320738 TI - Basal endothelial attachment. Tenacity at cytoplasmic dense zones in the rabbit aorta. PMID- 4320739 TI - The ultrastructure of spontaneous and experimentally induced arterial lesions. 3. The cholesterol-induced lesions and the effect of a cholesterol and oil diet on the preexisting spontaneous plaque in the chicken aorta. PMID- 4320740 TI - Lipid synthesis and transport in the normal and atherosclerotic aorta. An autoradiographic study of rat and rabbit aortae incubated and perfused with choline-H3 and oleic acid-H3. PMID- 4320741 TI - [Prevention of primary hypoxic organ lesions in liver transplantation using appropiate perfusion technics with Hb-free perfusion solutions]. PMID- 4320743 TI - [Results of angiotensin determination in renal hypertension]. PMID- 4320744 TI - [Endolymphatic administration of I-131-iodolipol in rectal cancer surgery]. PMID- 4320742 TI - [Tracheal and bronchotracheal resections]. PMID- 4320745 TI - Corticosterone and ACTH as treatments for Escherichia coli infection in chickens. PMID- 4320746 TI - Intestinal phytase and alkaline phosphatase of chicks: influence of dietary calcium, inorganic and phytate phosphorus and vitamin D3. PMID- 4320748 TI - [Selective vaginal hypothermia in inflammational adnexeal processes. (Preliminary report)]. PMID- 4320749 TI - [Clinical substantiation for removing pelvic lymph nodes in cancer of the uterus]. PMID- 4320747 TI - The adsorption of coagulation factors onto phospholipids. Its role in the reaction mechanism of blood coagulation. PMID- 4320750 TI - [Significance of endoscopy for the differential diagnosis of myoma of the uterus and ovarian tumors]. PMID- 4320751 TI - Herpetic infection of the middle and lower respiratory tract. PMID- 4320752 TI - The cytochrome system of heterotrophically-grown Rhodopseudomonas spheroides. PMID- 4320753 TI - Comparative study of thermal degradation of electron transfer particle and reconstituted respiratory chain. Relation of electron transfer to reactivation of submitochondrial particles. PMID- 4320754 TI - Differences in sensitivity to valinomycin and nonactin of various photophosphorylating and photoreducing systems of Rhodospirillum rubrum chromatpohores. PMID- 4320755 TI - "Squiggle-H2O". An enquiry into the importance of solvation effects in phosphate ester and anhydride reactions. PMID- 4320756 TI - On the relationship of the energy-linked transhydrogenase to energy-linked NAD+ reduction in Rhodospirillum rubrum. PMID- 4320758 TI - Electron transport in mammalian nuclei. II. Oxidative enzmes in a large-scale preparation of bovine liver nuclei. PMID- 4320759 TI - Quinone interaction with the respiratory chain-linked NADH dehydrogenase of beef heart mitochondria. PMID- 4320757 TI - The oxidase systems of Ascaris-muscle mitochondria. PMID- 4320760 TI - Erythemal activity of the cellular enteropathogenic factor of Clostridium perfringens type A. PMID- 4320761 TI - Induction of fasting hypoglycemia and hyperinsulinemia in the mouse by pituitary and urinary peptides. PMID- 4320762 TI - Effects of temperature on Drosophila. VI. Respiratory enzymes. PMID- 4320763 TI - [Mechanisms of the spontaneous rhythmic activity of the cerebral cortex]. PMID- 4320764 TI - Effect of estrogen on immobilization osteoporosis in rat. PMID- 4320765 TI - Thyroid secretion in vitro: multiple actions of agents affecting secretion. PMID- 4320766 TI - Regulation of glycogen metabolism in the adrenal gland. 3. Hormonal effects in vivo. PMID- 4320768 TI - Changes in the thyroidal content of thyrocalcitonin produced by vitamin D in rats. PMID- 4320767 TI - Studies on the delayed action of growth hormone on the metabolism of the rat diaphragm. PMID- 4320769 TI - Potentiation by vasopressin of corticotropin release induced by corticotropin releasing factor. PMID- 4320770 TI - ACTH and the differentiation of rat adrenal cortical cells grown in primary tissue culture. PMID- 4320771 TI - Comparative study of mitochondrial and cytosol proteinphosphatase. PMID- 4320772 TI - [Immunological determination of hormones and its clinical application in gynecolo obstetrical field]. PMID- 4320773 TI - [Repetitive neuronal discharge in slow and paradoxical sleep]. PMID- 4320774 TI - [Uptake of sugars by isolated rat diaphragm under the influence of somatotropin (STH): possible role of adenosine 3'5' monophosphoric acid (cyclic AMP)]. PMID- 4320775 TI - [Pituitary corticotropic activity at the end of gestation and during lactation in rats]. PMID- 4320776 TI - [Effect of paradoxical sleep deprivation on the acquisition and retention of conditioning in rats]. PMID- 4320777 TI - [Role of catecholamines in the cardiovascular action of angiotensin]. PMID- 4320778 TI - [Changes of sleep rhythms after an gamma irradiation in cats]. PMID- 4320779 TI - [Electrophysiological study, by telemetry, of the ventral tegmental area during sleep in rats]. PMID- 4320780 TI - Experimental studies on the effects of irritant gas and dust on the respiratory organs of gnotobiotes. PMID- 4320781 TI - [A case of juvenile fibroma in a 28-year-old woman]. PMID- 4320782 TI - The ulnar tunnel syndrome. PMID- 4320783 TI - [Diagnostic value of determining glucose-6-phosphatase activity in the blood serum of donors]. PMID- 4320784 TI - [Symptoms of irreversible termination of cerebral functions from the viewpoint of clinical neurophysiology]. PMID- 4320785 TI - [Renal angiography in Wilms' tumor]. PMID- 4320787 TI - [Regional hemodynamic changes due to section and degenerative lesions of the peripheral nerves. Experimental study with the electromagnetic flowmeter]. PMID- 4320786 TI - Release of the periplasmic penicillinases from Escherichia coli by toluene. PMID- 4320788 TI - [Tropical fitness examinations]. PMID- 4320789 TI - [Incidence and causes of hypovitaminosis D among persons in an old age home]. PMID- 4320790 TI - Suture absorption in rabbit cornea and sclera: enzyme histochemical and morphologic observations. PMID- 4320791 TI - Protection by polyinosinic-polycytidylic acid complex of rabbit eye tissue cultures infected with herpes simplex virus. Effect of neomycin and virus challenge dose. PMID- 4320792 TI - [Hepatoma with unusual symptomatology]. PMID- 4320793 TI - Spin label studies of hemoproteins. I. Cytochrome c. PMID- 4320794 TI - Regulation of pyruvate dehydrogenase from Escherichia coli. Interactions of adenylate energy charge and other regulatory parameters. PMID- 4320795 TI - Adenosine 5'-triphosphate-glucose and phosphoenolpyruvate-glucose phosphotransferase activities of liver microsomal glucose 6-phosphatase. PMID- 4320796 TI - The isolation of a brush border membrane fraction from rat kidney. PMID- 4320797 TI - The mechanism of action of ethanolamine ammonia-lyase, a B12-dependent enzyme. VII. The mechanism of hydrogen transfer. PMID- 4320798 TI - The absence of zinc in bovine liver glutamate dehydrogenase. PMID- 4320799 TI - Regulation of glycogen metabolism in polymorphonuclear leukocytes. PMID- 4320800 TI - An electron paramagnetic resonance study of the nonheme iron of cysteamine oxygenase. PMID- 4320801 TI - [A nerve tumor of the neck]. PMID- 4320802 TI - [Cellular immunotherapy of cerebral glioblastoma. Apropos of 2 results]. PMID- 4320803 TI - [2 cases of herpes gestationis]. PMID- 4320804 TI - [Neurocutaneous melanoblastoma]. PMID- 4320805 TI - [Liver tumors in children]. PMID- 4320806 TI - [Anesthesiologic considerations on a case of surgically treated cylindroma of the lower 3d of the trachea]. PMID- 4320807 TI - [Processes of realization of genetic information in human viruses]. PMID- 4320808 TI - [The bi-potency of reserve cells. Electron-microscopic sudies on indirect metaplasia]. PMID- 4320810 TI - [Histochemical determination of iron and cytochrome oxidase in the placenta of women suffering from cardiac disease]. PMID- 4320809 TI - Intestinal factors in the regulation of insulin secretion. PMID- 4320811 TI - Prevalence of complement-fixing antibodies to cytomegalovirus in a semirural southern county. PMID- 4320812 TI - [Cerebral gigantism]. PMID- 4320813 TI - Separation of delta-4-3-oxo steroids and delta-5-3-beta-hydroxy steroids by chromatography on digitonin-silica thin layers. PMID- 4320814 TI - Steroid metabolism by foetal sheep adrenals. PMID- 4320815 TI - The distribution of 131-I-labelled adrenocorticotrophin in the normal guinea pig. PMID- 4320816 TI - Effect of bivalent cations on some enzymes of gluconeogenesis. PMID- 4320818 TI - Distribution of arylsulphatase C in subcellular membranes of rat liver. PMID- 4320817 TI - Isolation of nicotinamide-adenine dinucleotide-cytochrome b5 oxidoreductase from rate liver microsomes. PMID- 4320819 TI - Specificity of action of adrenocorticotrophin in vitro on ascorbate transport in rat adrenal glands. AB - The inhibition of ascorbate transport by rat adrenal quarters in response to steroidogenesis in vitro was shown to be highly specific with respect to tissue, substrate and steroidogenic agent. The transport system in vitro is capable of net accumulation of ascorbate. The evidence is consistent with the conclusion that ascorbate ;depletion' in the adrenal gland is due to a specific block by corticoids of the uptake of ascorbate. PMID- 4320821 TI - Two techniques for the study of hepatic membrane-containing fractions. PMID- 4320820 TI - Membranes of the adrenal medulla. Behaviour of insoluble proteins of chromaffin granules on gel electrophoresis. AB - Washed membranes of bovine adrenal chromaffin granules contained most of the cholesterol and phospholipids of the particle and 22% of the total protein. The protein/lipid ratio was about 0.45 (w/w). Dopamine(3,4 dihydroxyphenethylamine)beta-hydroxylase, Mg(2+)-activated nucleoside triphosphatase and cytochrome b-559 activities were present in the membrane. ATP was the best substrate for the nucleoside triphosphatase, whose pH optimum was 6.4, K(m) 7x10(-4)m and V(max.) 1.8mumol/h per mg of protein. Treatment of the membranes with various detergents caused a preferential solubilization of protein compared with lipids. Membranes dissolved in sodium dodecyl sulphate or phenol acetic acid-urea were subjected to polyacrylamide-gel electrophoresis at alkaline and acid pH respectively. The electrophoretic patterns given by the proteins of the chromaffin granule membrane were distinct from those given by the chromogranins, and from those given by mitochondrial and microsomal membrane proteins. PMID- 4320822 TI - The measurement of bone mineral in vivo by photon beam scanning. PMID- 4320823 TI - [Effect of pantethine on the function of the adrenal cortex. 2. Clinical experience using pantethine in cases under steroid hormone treatment]. PMID- 4320824 TI - Lipids of ocular tissues. IV. A comparison of the phospholipids from the retina of six mammalian species. PMID- 4320825 TI - Fine structure of elasmobranch iris muscle and associated nervous structures. PMID- 4320826 TI - A curve-fitting procedure for the study of the binding of small molecules to multi-subunit proteins. PMID- 4320827 TI - [On the presence of carriers of "enterotoxic" Cl. perfringens in groups of butchers, cooks and waiters]. PMID- 4320828 TI - Relationship between chemical structure and antigenicity of angiotensin analogues. PMID- 4320830 TI - A serological study of whooping cough. PMID- 4320829 TI - Studies on the distribution of some histocompatibility antigens in mouse liver plasma membrane and microsomal fractions. PMID- 4320831 TI - Nerves in the arm in leprosy. 1. Clinical, electrodiagnostic and operative aspects. PMID- 4320832 TI - Prevalence of deformities and disabilities among leprosy patients in an endemic area. I. General findings. PMID- 4320833 TI - Bacterial degradation of biotin. IV. Metabolism of 14Carbonyl-labeled biotin l sulfoxide. PMID- 4320834 TI - Preparation and properties of 5'-nucleotidase from smooth muscle of small intestine. PMID- 4320835 TI - Stimulation of thyroidal phospholipid turnover by osmotic shock. PMID- 4320836 TI - Inactivation of glycogen synthetase and activation of phosphorylase kinase by muscle adenosine 3',5'-monophosphate-dependent protein kinases. PMID- 4320837 TI - Regulation of lac transcription in Escherichia coli by cyclic adenosine 3',5' monophosphate. Studies with deoxyribonucleic acid-ribonucleic acid hybridization and hybridization competition. PMID- 4320838 TI - Substrate-induced conformational changes of liver fructose 1,6-diphosphatase studied with the hydrophobic probe, 1-anilinonaphthalene-8-sulfonate. PMID- 4320839 TI - The ultrastructural distribution of several phosphatase enzymes in mouse mammary tumor system. PMID- 4320840 TI - [Association of embryonic antigens with hepatoma and other hepatic lesions in rats: current state of the question]. PMID- 4320841 TI - [A differential cinespectrophotometer]. PMID- 4320842 TI - [Role of adenovirus in the etiology of respiratory diseases in children]. PMID- 4320843 TI - [Ovarian arrhenoblastoma]. PMID- 4320844 TI - [Endocrine hypertension]. PMID- 4320845 TI - [Renal hypertension]. PMID- 4320846 TI - [Angiotics. 48. I. Hypertensive agents. II. Hypotensive agents. 3. Vasodilator agents. IV. Agents for the treatment of lipid metabolism disorders]. PMID- 4320847 TI - Infrared studies of isolated normal and tumour DNA. PMID- 4320848 TI - Radical excision of a fibro-fatty proliferation of the median nerve, with no neurological loss symptoms. PMID- 4320849 TI - Studies in vivo on the control of oestrogen secretion in human pregnancy. PMID- 4320850 TI - Endocrine factors in the onset of labour. PMID- 4320851 TI - [Dosage of insulin levels using radioimmunoassay with double antibodies]. PMID- 4320852 TI - [Survey of bovine tuberculosis by means of tuberculin test in various regions of West Africa (Upper Volta and Ivory Coast): results and general considerations]. PMID- 4320854 TI - [Ovarian tumors]. PMID- 4320853 TI - [Choriocarcinoma and trophoblastic disease]. PMID- 4320855 TI - [Effects of L-DOPA on sleep spindles in patients with parkinsonism]. PMID- 4320856 TI - [On an unusual disorder of erect standing position (observation of 3 cases)]. PMID- 4320857 TI - A glomus jugulare tumour. PMID- 4320858 TI - Cerebral form of generalized cytomegaly of early infancy. Light and electron microscopic findings. PMID- 4320859 TI - Impairment of the pituitary-adrenal axis following prolonged therapy with corticotrophin. PMID- 4320860 TI - Polyneuropathies of undetermined cause. PMID- 4320861 TI - Continuous-flow ultracentrifugation of canine distemper virus and infectious canine hepatitis virus. AB - The use of a Spinco L-4 zonal centrifuge with the B-XVI continuous-flow rotor for the purification of canine distemper and infectious canine hepatitis viruses is described. Up to 68 liters of virus was processed at one time. Infectious canine hepatitis virus was found to band at 39% sucrose and canine distemper virus banded between 32 and 48% sucrose. The virus was concentrated 10-fold, and the purity of the virus, as measured by protein concentration, was increased by 99%. PMID- 4320862 TI - Polysaccharide from dry navy beans, Phaseolus vulgaris: Iits isolation and stimulation of Clostridium perfringens. AB - A microbiological assay is described for determining gas produced by Clostridium perfringens (Veilon and Zuber) Holland from materials believed to be flatulent. A rationale for its use is given and analyzed. The fractionation and the results of the assay for several components of lima beans, Phaseolus lunatus L., and navy beans, P. vulgaris L., are given. In particular, a polysaccharide was isolated from dried P. vulgaris seeds. Only about one-seventh as much could be isolated from green P. lunatus seeds as from P. vulgaris seeds. The polysaccharide stimulates voluminous gas production by C. perfringens and meets all criteria of the rationale for flatulent sus pects. It has not been tested on humans; however, data from the microbiological assay correlate well with human results for green and dry lima beans and navy beans. PMID- 4320863 TI - Lyophilization of cell-free Marek's disease herpesvirus and a herpesvirus from turkeys. AB - Cell extracts of the JM and GA strains of Marek's disease herpesvirus and the FC 126 strain of turkey herpesvirus were lyophilized with various stabilizers. Much higher virus titers were obtained with stabilizer than without stabilizer. Titers increased even further in the case of the Marek's disease virus strains by the addition of a chelating agent, disodium ethylenediaminetetraacetate. PMID- 4320864 TI - Growth of mouse L cells in shaken culture and mengovirus plaque formation on L cells suspended in agar. AB - Procedures are described that require a minimum of equipment and maintenance for growing mouse L cells suspended in liquid medium and for plaquing mengovirus on L cells suspended in agar. Viability of L cells during storage for 1 to 2 hr at relatively high concentrations was better in media at 30 C than at 0 C, as measured by viable counts after growth for 24 hr at 35 C. The number and size of plaques increased with increasing concentration of NaHCO(3) in the agar layers, but the relative difference in plaque size was maintained. Large- and small plaque-size variants had similar virulence as determined by the rates of viability loss of L cells in liquid suspension cultures. PMID- 4320865 TI - Quantitation of the antigenicity and immunogenicity of purified foot-and-mouth disease virus vaccine for swine and steers. AB - The antigenicity and immunogenicity of a purified preparation of foot-and-mouth disease virus [type A(12), strain 119 (FMDV A-119)] inactivated with 6.0 mmN acetylethylenimine at 37 C were compared in swine and steers. Three antigen doses were tested, 640, 160, and 40 ng. In accordance with findings for guinea pigs, as previously determined by dose-response curves, as little as fourfold changes in antigen in the region of the minimum effective dose produced marked differences in the serological and immune responses of swine. The minimum effective dose of antigen for antibody formation in swine and guinea pigs, as determined by mouse median protective dose (PD(50)) values, was 160 ng. The minimum immunogenic dose for swine was also 160 ng. The vaccinated swine were challenged with either FMDV A-119 or with heterologous subtype A(24) strain Cruzeiro or type A strain A CANEFA-1. Those immunized with 640 ng of antigen were about equally immune to the three challenge viruses; most swine having a mouse PD(50) value of 2.0 or greater were immune regardless of which strain was used for challenge. In steers, the smallest dose tested, 40 ng, was satisfactory in eliciting circulating antibodies and immunity. Physical and biological tests indicated that the antigen used in the vaccine is stable for at least 9 months at 4 C. PMID- 4320867 TI - The effect of parathyroid extract on collagen of the aortas of rats fed a lipid rich diet. PMID- 4320866 TI - Effect of poly I: C on experimental respiratory infection in hamsters. AB - The interferon inducer double-stranded polyinosinic acid and polycytidylic acid (poly I:C) was studied in hamsters experimentally infected with parainfluenza 3 virus. Upper intranasal, deep intranasal, or intraperitoneal treatment of hamsters with poly I:C (100 mug/100- to 120-g animal) 24 hr before an upper respiratory infection significantly reduced the virus yields taken 28 hr after infection. Deep intranasal and intraperitoneal treatment with poly I:C greatly decreased the virus titers in the lungs, as measured 48 hr after a deep lung infection with parainfluenza 3 virus; however, the upper respiratory poly I:C treatment was ineffective. PMID- 4320868 TI - Chronic cor pulmonale. Its pathogenesis in Appalachian bituminous coal workers. PMID- 4320869 TI - Combined Pneumocystis carinii and cytomegalovirus infection. PMID- 4320870 TI - Effects of some drugs on the responses of the rat isolated, innervated urinary bladder to indirect electrical stimulation. AB - 1. The effects of some drugs known to inhibit transmission in the superior cervical ganglion and at the neuromuscular junction were investigated on the cholinergic nerve-smooth muscle junction, using the rat isolated innervated urinary bladder preparation.2. HC-3 and Win 4981 inhibited the indirectly evoked contractions; the block was typically slow in onset, depended on the rate of stimulation and was partially reversed by choline. The moderate coincident inhibition of acetylcholine-responses disappeared after washing the tissue, while the block of the neuronally evoked contractions persisted.3. Morphine, methylpentynol carbamate, chloral hydrate and strychnine inhibited indirectly evoked contractions without inhibiting the responses to acetylcholine. Paraldehyde inhibited both types of response.4. Hexamethonium, mecamylamine and tubocurarine had no effect on either type of response. Tetraethylammonium augmented both types of response; the augmentation due to lower concentration was followed by a moderate block of the neuronally evoked contractions.5. Small concentrations of procaine markedly inhibited responses to acetylcholine and produced a partial block of the neuronally evoked contractions.6. None of the drugs affected conduction in the isolated phrenic nerve.7. All the drugs other than paraldehyde and procaine appeared to act at the nerve terminals. The results are generally consistent with the view that HC-3 and Win 4981 act by limiting transport of choline across nerve membrane and that the other drugs act by inhibiting the release of acetylcholine. A reduction in sensitivity of the effector cell membrane may account, wholly or in part, for the action of paraldehyde and procaine. PMID- 4320871 TI - Hyposensitivity to drugs induced by morphine and some related substances in the cat. AB - 1. Hyposensitivity to noradrenaline occurred concomitantly with morphine tachyphylaxis in the absence of any obvious depressant effect on the heart or peripheral circulation.2. The actions of adrenaline, noradrenaline and angiotensin and, occasionally, other drugs were tested before and after repeated injections of morphine or one of ten related substances in various preparations of the spinal cat.3. Tachyphylaxis in response to morphine could be related to a simultaneous decrease in the tissue responses to adrenaline, noradrenaline and angiotensin but such a parallelism has not been shown for the substances related to morphine. PMID- 4320872 TI - Effect of cellulose sulphate on serum complement. AB - Cellulose sulphate 50-600 mug/ml reduces complement titres in human serum. This effect is, in contrast to the clot-promoting and plasma kinin forming action of cellulose sulphate, not mediated by clotting factor XII. PMID- 4320873 TI - Whooping-cough due to adenovirus. PMID- 4320874 TI - Mammary-tumor virus activity in brain and liver of GR strain mice. PMID- 4320875 TI - Inhibition of polyoma-virus oncogenesis in rats by polyriboinosinic-ribocytidylic acid. PMID- 4320876 TI - Cell-free transmission of murine myeloid leukaemia. PMID- 4320877 TI - [Is diaquo-bis-(N-2-picolyloxamidate)-cobalt (II) a model compound for the structure of the active center of an alkaline phosphatase?]. PMID- 4320878 TI - Isoelectric focusing of neuraminidase. PMID- 4320879 TI - The pathogenic role of the inflammatory reaction in poliomyelitis. Immunofluorescence, electron-microscopic and virological studies with type 3 poliovirus. PMID- 4320881 TI - A psychophysiology for all states. PMID- 4320880 TI - Recent advances in avian endocrinology. 4. Neurohumoral control of the avian adrenal: A review. PMID- 4320883 TI - The behavioral effects of REM sleep deprivation in rats. PMID- 4320882 TI - Sleep mentation and auditory awakening thresholds. PMID- 4320884 TI - Home and laboratory dreams collected under uniform sampling conditions. PMID- 4320885 TI - Tracheal resection with end-to-end anastomosis. PMID- 4320886 TI - The use of a computer in patient follow-up in Scotland. PMID- 4320887 TI - [Pseudo-tumoral mediastinal lymph node toxoplasmosis]. PMID- 4320888 TI - [Significance of medullary transposition in the treatment of paraplegia due to kyphosis and kypho-scoliosis]. PMID- 4320889 TI - [5' nucleotidase: a specific hepato-biliary alkaline phosphatase]. PMID- 4320890 TI - [Transient iatrogenic lupus erythematosus with erythroblastopenia and granulopenia]. PMID- 4320891 TI - [Several particular complications of acute diarrhea in infants]. PMID- 4320892 TI - [Statistical study of epileptic crises appearing after 60 years of age]. PMID- 4320893 TI - [Epileptic crises occurring after the age of 60 years observed in practice of neurology in a neuro-surgical department]. PMID- 4320894 TI - [Study of etiologic and prognostic factors in epilepsy with the onset after 60 years of age]. PMID- 4320895 TI - [Epilepsy after 60 years of age. Experience in a functional neurosurgical department]. PMID- 4320896 TI - [Study of 51 records of epilepsy with the onset after 60 years of age]. PMID- 4320897 TI - [Demographic findings on epilepsy with late onset]. PMID- 4320898 TI - [Correlations between antibodies and renal lesions in the urinary infections]. PMID- 4320899 TI - [Case report of severe encephalitis in infectious mononucleosis observed in a neurosurgical department]. PMID- 4320901 TI - The interaction of P. bergheii yoelii infection in mice with murine oncogenic viruses. PMID- 4320900 TI - [Neuropathy caused by vibrations]. PMID- 4320902 TI - Studies on arbovirus epidemiology associated with established and developing rice culture. Introduction. PMID- 4320903 TI - Long-acting synthetic corticotrophin in dermatology. PMID- 4320904 TI - Trials with prophylactic treatment of parturient paresis. PMID- 4320906 TI - [The adrenogenital syndrome]. PMID- 4320905 TI - Isolation and characterisation of a reovirus from pigs. PMID- 4320907 TI - The epizootiology and epidemiology of foot and mouth disease. PMID- 4320908 TI - Antagonism of smooth muscle contractility by catecholamines. PMID- 4320909 TI - Role of kidney in gluconeogenesis and amino acid catabolism. PMID- 4320910 TI - Effect of angiotensin I on intrarenal blood flow distribution. PMID- 4320911 TI - Differential effects of substrate depletion on drug-induced contractions of rabbit aorta. PMID- 4320912 TI - Developmental changes in ATPase and K plus-stimulated phosphatase of tadpole gastric microsomes. PMID- 4320913 TI - Reflex vasodilatation and sympathetic transmission in the renal hypertensive dog. PMID- 4320914 TI - Central inhibition of reflex vasodilatation by angiotensin and reduced renal pressure. PMID- 4320915 TI - Sympathetic unit activity associated with Mayer waves in the spinal dog. PMID- 4320916 TI - Effect of local cooling on responsiveness of muscular and cutaneous arteries and veins. PMID- 4320917 TI - Unstirred layers in tissue respiration: application to studies of frog gastric mucosa. PMID- 4320918 TI - Assessment of aerosol mixtures of different viruses. AB - Aerosol mixtures of the psittacosis agent, yellow fever virus, and variola virus were assayed by selective immunofluorescence in conjunction with fluorescent cell counting. The aerosol behavior of each agent could be readily delineated at test conditions of 80 F (26.67 C) and three relative humidities (30, 50, or 80%). Of the three agents, variola virus exhibited the lowest biological decay. The biological decay rates of the airborne agents were not significantly affected by humidity changes. PMID- 4320919 TI - Rapid sensitive assay for interferons based on the inhibition of MM virus nucleic acid synthesis. AB - A method for assaying mouse interferon based on the inhibition of viral ribonucleic acid (RNA) synthesis was devised. The amount of MM virus and RNA synthesized in interferon-treated L-cell cultures was determined by measuring the amount of (3)H-uridine converted into a trichloroacetic acid-insoluble form after treatment of the infected cultures with 2.5 mug of actinomycin D per ml. The amount of RNA synthesized was inversely related to the concentration of interferon used for treatment. A linear dose-response regression curve was obtained by plotting the log of the amount of RNA made, expressed as a percentage of the control, versus the log of the reciprocal of the interferon dilution. A unit of interferon was defined as that concentration which inhibited nucleic acid synthesis by 50% (INAS(50)). The concentration of mouse interferon could be determined within 24 hr. This assay method, on the average, was approximately half as sensitive as the method which measured the 50% reduction of MM virus plaque number (PDD(50)-MM method), but was, on the average, almost 1.7 times as sensitive as the PDD(50)-VSV method. It averaged approximately 20 times the sensitivity of the methods which used as end points the 70% reduction in yield of MM virus or the complete inhibition of cytopathic effect by MM virus. The reproducibility of the INAS(50) technique was tested in two ways. (i) Four independent assays of an interferon specimen were performed with replicate cultures. The standard deviation was 11.2% of the mean titer. (ii) On different dates, one interferon specimen was assayed seven times and another was assayed four times. The standard deviations were 21.5 and 26.6% of the respective mean titers. PMID- 4320920 TI - Complement fixation reaction for the diagnosis of type II avian (Marek's) leukosis. AB - The present study was designed to find a complement fixation (CF) reaction for the diagnosis of type II lymphoid leukosis, to learn some of the characteristics of the CF antigen, and to investigate the development of CF antibody response to this infection. JM virus-specific antigen was demonstrated in tumorous chicken tissue, in JM virus-infected chick embryo material, in JM virus-infected chicken kidney, and in duck embryo fibroblast tissue culture by using JM virus-immune rabbit serum. This CF antigen did not show cross-reactivity with Rous sarcoma virus or with RIF-type viruses. It was partially heat-labile. The CF activity was restored at -70 C for 10 months and was resistant to intermittent freeze-thaw treatment. The CF antigen may be denatured by ethyl alcohol, but no significant deleterious effects were noted after ether or chloroform treatment. JM virus specific CF antibody could not be demonstrated by the direct complement dilution method or by the indirect or inhibition form of the CF test in infected or immunized chicken sera. PMID- 4320921 TI - Viral aggregation resulting in the failure to correctly identify an unknown rhinovirus. AB - A seed lot of strain SF 1684 of rhinovirus type 2 prepared in human embryonic lung cells (WI-38) contained aggregates which interfered with its neutralization by homotypic or homologous antisera. The same virus showed no evidence of aggregation at five other passage levels studied. Virus in the seed lot was not identified correctly, and the titer of homologous antiserum was mistakenly considered to be low as a result of neutralization tests conducted with the aggregated virus. Filtration and a more easily effected treatment with sodium deoxycholate (1%) disaggregated the virus and restored its susceptibility to neutralization by homologous and homotypic antiserum. PMID- 4320922 TI - Oxidation-reduction potential and growth of Clostridium perfringens and Pseudomonas fluorescens. AB - A new apparatus was developed for measuring changes in E(h), pH, and cell numbers. With this apparatus, the relationships of these parameters were studied at initial E(h) levels of 200 and 40 mv (pH 7.0), by using Clostridium perfringens and Pseudomonas fluorescens. One of the strains of C. perfringens grew more luxuriantly at the higher E(h), in the presence of small quantities of oxygen, than at the lower one in the absence of oxygen. P. fluorescens could grow at a relatively low E(h) (40 mv, pH 7.0) in pure culture but not in the presence of C. perfringens under the same conditions. PMID- 4320923 TI - The binding of kinetin to plant ribosomes. AB - The synthetic cytokinins kinetin and 6-benzylaminopurine exhibit equilibrium-type binding to purified chinese-cabbage leaf ribosomes. At 23mum and 4 degrees C one molecule of kinetin and 1.34 molecules of 6-benzylaminopurine are bound per ribosome. Adenine and adenine derivatives that are inactive as cytokinins showed much less affinity for ribosomes. Pretreatment of ribosomes with 0.5m-ammonium chloride or Triton X-100 did not decrease the extent of cytokinin binding. Binding appeared to be to the 83S ribosome species. A positive correlation between the extent of binding and the biological effect of various cytokinin analogues was demonstrated. These results are discussed in terms of cytokinin control of growth processes at the ribosomal level. PMID- 4320925 TI - [Spectrum changes of free fatty acids in the plasma of rats with experimental nephrogenic hypertension]. PMID- 4320924 TI - Tissue-characteristic forms of glyceraldehyde 3-phosphate dehydrogenase. AB - Glyceraldehyde 3-phosphate dehydrogenase exists in two different forms in various human tissue preparations. One of them is exhibited, after starch-gel electrophoresis, by a rapidly migrating or ;fast' band and the other by a ;slow' band. The proportion of the total activity in each of the two forms is characteristic of the type of tissue. A particulate fraction, obtained after centrifugation of homogenates, inhibits the enzyme activity and tends to convert the slow band into a fast one. The conversion is reversible. The fast band can also be converted into the slow one by addition of NAD(+) or ADP, or by dialysis against saturated sodium chloride solution. Conversions occur with the purified enzyme as well as with crude homogenates. The relevance of these findings to previous investigations and to glycolytic control mechanisms are discussed. PMID- 4320926 TI - A case of the Zollinger-Ellison syndrome associated with hyperplasia of salivary and Brunner's glands. AB - A case is reported showing enlargement of the salivary gland with hypersecretion and Brunner's gland hyperplasia in the Zollinger-Ellison syndrome. Gastric hypersecretion and diarrhoea were prominent, but there was no peptic ulceration. PMID- 4320927 TI - Use of conglutinating complement absorption inhibition test for detecting arbovrus inhibiting antibodies in chicken sera. PMID- 4320928 TI - Effect of antidiuretic hormone (ADH) and angiotensin on the urine flow of rats during negative pressure respiration induced diuresis. PMID- 4320929 TI - Relationship of undernutrition to diarrhoea in infants and children. PMID- 4320930 TI - The occurrence and distribution of intestinal parasites in Sikki. PMID- 4320931 TI - The management of bacteremic shock. PMID- 4320932 TI - The plasma concentrations of corticosteroids in normal and diseased horses. PMID- 4320933 TI - The present status of the leukemia-sarcoma complex in man and lower animals. PMID- 4320934 TI - Demineralization of bone by phosphoprotein phosphatase. PMID- 4320935 TI - Poliomyelitis on Taiwan. II. Virological and serological surveys before and after mass Sabin vaccination. PMID- 4320936 TI - lac repressor--operator interaction. II. Effect of galactosides and other ligands. PMID- 4320938 TI - Coding specificity of Escherichia coli leucine transfer ribonucleic acids and effect of bacteriophage T2 infection. PMID- 4320937 TI - Alanine acceptance and transfer by nitrous acid-modified yeast alanine transfer ribonucleic acid. PMID- 4320939 TI - RNA synthesis in cells infected with herpes simplex virus. 3. Absence of virus specified arginyl- and seryl-tRNA in infected HEp-2 cells. PMID- 4320940 TI - Isolation of amino acid acceptor RNA from purified avian myeloblastosis virus. PMID- 4320941 TI - The fine structure of coelomocytes in the annelid Enchytraeus fragmentosus. PMID- 4320942 TI - [Microbiological diagnosis in amebiasis]. PMID- 4320943 TI - [Irradiation of the ovaries in the complex therapy of breast cancer]. PMID- 4320944 TI - [Therapy of some peripheral nervous system diseases with Tl-204 applicators]. PMID- 4320945 TI - Patients helping patients. PMID- 4320946 TI - Release of the chronic psychiatric patient. PMID- 4320948 TI - [Epulis congenita]. PMID- 4320947 TI - Some metabolic effects of dietary sucrose. PMID- 4320949 TI - [Determination of adenovirus antibodies by simple radial immunodiffusion techniqu]. PMID- 4320950 TI - [Current problems of hydrocyanic poisoning: biological, clinical and therapeutic aspects]. PMID- 4320951 TI - [Points of view on the surgery of irreparable nerve paralysis]. PMID- 4320952 TI - [The problem of cicatricial lung carcinoma]. PMID- 4320954 TI - SV40-tumorigenesis in mouse. PMID- 4320953 TI - Studies on the possibility of obtaining leukosis-free eggs from commercial poultry flocks, with reference to current laboratory methods. PMID- 4320955 TI - Isolation of a herpes-type virus from chickens with acute Marek's disease in Denmark. PMID- 4320957 TI - Prejunctional supersensitivity in the rat portal vein as related to its pattern of innervation. PMID- 4320958 TI - [Welchicins, bacteriocins produced by Clostridium perfringens]. PMID- 4320956 TI - Complement-fixing and virus-neutralizing antibodies in cytomegalovirus infection as measured against homologous and heterologous antigen. PMID- 4320959 TI - A comparison of two cell culture systems for the primary isolation of enteric viruses. AB - Several studies have been reported on the comparative susceptibility of various cell cultures for the primary isolation of enteric viruses. The present report gives a comparison of human embryo kidney cells and rhesus monkey kidney cells for the primary isolation of viruses from faecal specimens. Altogether, 148 enteroviruses, covering 21 serotypes, and 20 adenoviruses were isolated. The marked sensitivity of human embryo kidney cells to adenoviruses was again demonstrated. These cells, however, were found to be significantly less sensitive than rhesus monkey cells for the isolation of the enteroviruses encountered. This finding is in conflict with the results of a previous study and is partly explained by the difference in enterovirus composition of the two series. The value of human embryo kidney cells for the primary isolation of enteric viruses would seem to be closely related to the prevalence of adenoviruses and certain coxsackievirus A serotypes in the population studied. PMID- 4320960 TI - The ultrastructure of Entamoeba histolytica. AB - The ultrastructure of the trophozoite of Entamoeba histolytica cultivated in vitro on artificial media is described from electron-microscope studies made by the authors and from other published accounts. The authors point out that the description does not present a complete picture of the trophozoite of this species of amoeba since no detailed studies of the dysenteric form in infected host organs have yet been made and that nothing is known about the ultrastructure of cysts and the process of cyst formation, maturation and germination.The cytoplasm is confined by a 3-layered cytoplasmic membrane and contains many different organelles: subpellicular dark bodies, ribosomes, helical aggregates of ribosomes, osmiophilic lipoid granules, short dark tubular bodies of unknown origin and function, food vacuoles and some very small vacuoles thought to be lysosomes. Neither mitochondria nor a Golgi apparatus could be found. In the nucleus, the chromatin material is accumulated around the periphery and the nucleolus is centrally situated. The nuclear envelope is a double-layered membrane with numerous pores. Some groups of button-like particles were seen within the nucleus and it is thought that they are probably symbiotic virus-like particles.Some comparisons are made with the ultrastructure of other amoebae, both parasitic and free-living, and some further lines of study are suggested. PMID- 4320961 TI - Plasma renin activity and the effects of deoxycorticosterone acetate in dogs with chronic left ventricular overload. PMID- 4320963 TI - [Dual nature of the negative phase of the primary response of the rabbit sensory motor cortex]. PMID- 4320962 TI - Mechanism of antihypertensive action of prolonged administration of hydrochlorothiazide in rabbit and dog. PMID- 4320964 TI - [Significance of afferents in the formation of neuron interrelations in the frog cerebellar cortex]. PMID- 4320965 TI - [Neuromuscular transmission time and time parameters of neural and muscular action potentials during Vvedenskii's pessimum]. PMID- 4320967 TI - [Cylindroma of the middle ear]. PMID- 4320966 TI - [Indications for bronchography]. PMID- 4320968 TI - [Voluminous Abrikosov's tumor of the larynx]. PMID- 4320969 TI - [Case of mixed tumor of the skin of the external ear canal]. PMID- 4320970 TI - [Alpha fetoprotein in the diagnosis of primary liver cancer]. PMID- 4320971 TI - [Rapic ACTH test]. PMID- 4320972 TI - An experience with Clostridium perfringens in cesarean derived barrier sustained mice. PMID- 4320974 TI - Behavior of tissue culture cells infected with polyoma virus. AB - Infection of tissue culture cells with the oncogenic polyoma virus, or its temperature-sensitive mutant Ts-a, causes several changes other than the previously known induction of cellular DNA synthesis. Cellular movement, survival, and mitotic rate are enhanced in low-serum medium, and morphology is changed; the cellular growth parameters, wound serum requirement, and topoinhibition are markedly decreased. The changes are similar to those that occur in cell transformation and are produced by viral functions known to be expressed in transformed cells. Clues as to the possible mechanisms of all these changes are analyzed and a possible mechanism is discussed. PMID- 4320973 TI - Release of pituitary growth hormone by prostaglandins and dibutyryl adenosine cyclic 3':5'-monophosphate in the absence of protein synthesis. AB - Effects of prostaglandins on the incorporation of [4,5-(3)H]leucine into growth hormone and its subsequent release into the incubation medium were studied. Incubation of rat anterior pituitary glands with 10(-6) M prostaglandin PGE(1) in tissue culture medium 199 for 7 hr caused a 40-300% increase in the release of labeled growth hormone into the incubation medium. PGE(1) at 10(-8) M increased growth hormone synthesis but not release. At 10(-6) M, PGE(2) had effects similar to PGE(1); PGA(1) increased growth hormone synthesis but not release. PGF(2alpha) was without effect on either synthesis or release of growth hormone.Prolactin synthesis and release were not affected by prostaglandins. All of the prostaglandins, at 10(-4) M, increased adenyl cyclase activity in the pituitary gland but phosphodiesterase activity was unaltered. Dibutyryl cyclic AMP, with or without caffeine, caused an up to 300% increase in labeled growth hormone release. No consistent effect of prolactin was observed. If potassium concentration was increased 10-fold, a 215% increase in growth hormone release was observed. A combination of hypertonic potassium and 10(-6) M PGE(1) increased growth hormone release 325%, suggesting that potassium and prostaglandins act by independent mechanisms. Addition of theophylline to pituitary gland, incubated in vitro, increased both the synthesis and release of growth hormone. Although fluoride greatly stimulated growth hormone release, it completely inhibited the incorporation of leucine into the hormone. Similarly, puromycin inhibited synthesis of growth hormone but did not block release induced by prostaglandin, dibutyryl cyclic AMP, theophylline, or fluoride. Prostaglandins increase pituitary adenyl cyclase activity and, presumably via cyclic AMP, increase growth hormone release, independently of protein synthesis. PMID- 4320975 TI - Overgrowth-stimulating activity of disrupted chick embryo cells and cells infected with Rous sarcoma virus. AB - Sonically disrupted chick embryo cells markedly stimulate DNA synthesis and cell multiplication when added to the medium of population density-inhibited cultures of such cells, but have little effect on the growth rate of sparse cultures. Sonicates from density-inhibited chick embryo cultures have as much overgrowth stimulating activity as do sonicates from actively growing cells. Sonicates from cells infected with Rous sarcoma virus show markedly increased overgrowth stimulating activity 4 days after infection. The activity in Rous-cell sonicates falls back to near normal amounts at 6 days concurrently with the appearance of a high content of overgrowth-stimulating activity in the medium. The active material is nondialyzable. It seems that growth-inhibited cells contain material in a sequestered location which, when released, can stimulate rapid growth in similarly inhibited cells. PMID- 4320976 TI - Electron spin resonance studies of carbonic anhydrase: transition metal ions and spin-labeled sulfonamides. AB - Electron spin resonance (esr) spectra of Cu(II) and Co(II) carbonic anhydrase, and a spin-labeled sulfonamide complex of the Zn(II) enzyme, are reported. The coordination geometry of Cu(II) bound in the enzyme appears to have approximately axial symmetry. Esr spectra of enzyme complexes with metal-binding anions also show axial symmetry and greater covalency, in the order ethoxzolamide < SH(-) < N(3) (-) 9. 3. The essential thiol group is protected by NADH against reaction with maleimide. 4. Lactate dehydrogenase in which the essential thiol group has been converted into an S-sulpho group or alkylated with maleimide still binds one molecule of NADH/subunit but with a three- to four-fold diminished affinity. 5. The inhibited enzymes also bind one molecule of NAD(+)-sulphite complex/subunit but with affinity decreased 10(3)-10(4)-fold. 6. The inhibited enzymes fail to bind C(2) and C(3) molecules to give the ternary complexes enzyme-NAD(+) pyruvate, enzyme-NADH-oxamate and enzyme-NADH-oxalate. The 1:1:1 stoicheiometry of the last-mentioned complex with the native enzyme was established by gel filtration. 7. Structures that account for these results are discussed. PMID- 4321895 TI - Physical studies of the interactions of acetylcholine chloride with membrane constituents. AB - The binding of acetylcholine to pure lipids, and lipids, proteins and lipoproteins extracted from synaptic membranes, was investigated by monolayer and n.m.r. techniques. No specific binding of acetylcholine could be detected at the concentration used, although its muscarinic and nicotinic antagonists [atropine and (+)-tubocurarine respectively] could be shown to interact with the membrane components. It is concluded that the binding of the nicotinic and muscarinic antagonists of acetylcholine is not necessarily indicative of the existence of a specific acetylcholine receptor. Measurements of the displacement of (45)Ca(2+) from monolayers of phosphatidylserine by acetylcholine and the variation of electrophoretic mobility of phosphatidylserine particles with concentration of acetylcholine indicated that in these systems acetylcholine was acting as a counterion at the negatively charged lipid interface. But studies of the salting in and salting-out of negatively charged lipid aggregates showed that acetylcholine and other quaternary ammonium compounds did not here behave simply as counterions. Electrostrictively hydrated cations such as Na(+) and K(+) were found to salt out, whereas hydrophobically hydrated cations such as acetylcholine salted in such aggregates. The possible role of the hydration of acetylcholine in synaptic transmission is discussed. PMID- 4321897 TI - Effect of 2,4-dinitrophenol on the rate of ethanol elimination in the rat in vivo. PMID- 4321896 TI - Terminal-sequence studies of high-molecular-weight ribonucleic acid. The 3' termini of rabbit reticulocyte ribosomal RNA. AB - Sequences of the polynucleotide chains of RNA found in the large and small ribosomal subunits of rabbit reticulocytes have been determined from the 3'-end by use of periodate oxidation and condensation with [(3)H]isoniazid and by stepwise degradation. By these methods the hexanucleotide sequences have been found as -pGpUpUpUpGpU for the 28S RNA and -pGpUpCpGpCpU for the 6S RNA of the large ribosomal subunit and the octanucleotide sequence -pGpApUpCpApUpUpA for the 18S rRNA of the small ribosomal subunit. These sequences are present in at least 70% of all the RNA molecules and are discussed in relation to the specific cleavage of rRNA from its precursors and the role of multiple cistrons for rRNA in the DNA of higher organisms. The feasibility of using the method for longer sequence determinations is discussed. PMID- 4321898 TI - Electron microscopic evidence suggesting the myogenous derivation of the so called alveolar soft part sarcoma. PMID- 4321899 TI - Carcinosarcomas and mixed mesodermal tumors of the ovary. PMID- 4321900 TI - Significance of catecholamine excretion in the follow-up of sympathoblastomas. PMID- 4321902 TI - A cytophotometric study of nuclear DNA content of cyto-and syncytiotrophoblast in trophoblastic disease. PMID- 4321901 TI - Primary malignant tumors of the liver. PMID- 4321903 TI - [Biosynthesis of transcortin. Role of cyclic 3',5'-adenosine monophosphate in cellular mechanisms of biosynthesis]. PMID- 4321904 TI - [An ultramicro method for the fluorimetric determination of serum triglycerides]. PMID- 4321905 TI - Glucose-6-phosphatase deficiency and hyperlipaemia. PMID- 4321906 TI - [Heterotransplantation of some human carcinomas using diffusion chambers]. PMID- 4321907 TI - Direct spectrophotometric determination of the structure of dinucleoside monophosphates. PMID- 4321908 TI - [Pituitary corticotropin function in hypertonic obesity "with rose striae"]. PMID- 4321909 TI - [Evaluation of the angiotensin tolerance test in the diagnosis of adrenal insufficiency]. PMID- 4321910 TI - Intrasplenic angiotensin--a simple test for the diagnosis of porto-systemic venous anastomosis. PMID- 4321911 TI - Karyotypic analysis of three established transplantable tumors in ascitic form. PMID- 4321912 TI - Differential membranolytic effects of microcrystalline sodium urate and calcium pyrophosphate dihydrate. AB - Microcrystals of sodium urate produced direct lysis of erythrocyte membranes, as had been described previously for silica. Calcium pyrophosphate crystals induced modest erythrocyte hemolysis, also, and time-course experiments showed a markedly different reaction curve from those produced by silica and urate. Polyvinylpyridine-N-oxide, a strong hydrogen acceptor, was bound from solution to urate and silica, but not to calcium pyrophosphate crystals; this compound effectively blocked urate and silica, but not calcium pyrophosphate or control hemolysis. Dextran and heparin inhibited urate-but not silica-induced hemolysis. If erythrocyte and lysosome membranes react similarly to these particles, then the absence of phagosomes in gouty synovial fluid leukocytes, and the presence of these structures in pseudogout, may be explained. PMID- 4321913 TI - Restriction of herpes simplex virus by macrophages. An analysis of the cell-virus interaction. AB - Macrophages restrict herpes simplex virus replication and can prevent the development of herpetic disease in mice. In an attempt to define the nature of this restriction, an analysis of virus-specified macromolecular syntheses in infected macrophages was undertaken. The significant results were the following: All cells were killed, but the infection was considered to be abortive since the level of infectious virus in macrophage cultures dropped steadily to a level beyond detection by 25 hr after infection. This restriction appeared to be specific for macrophages; the virus replicated efficiently in other mouse cells. DNA with a density characteristic for herpes simplex virus DNA was extracted from infected cultures, and the proportion of macrophages synthesizing DNA increased from less than 1% to greater than 50% by 6 hr after infection. Studies employing polyacrylamide gel electrophoresis indicated that the major viral-specific proteins were induced in macrophage cultures. In addition, all cells showing cytopathic changes characteristic of herpes virus infection also contained viral antigens which could be detected by fluorescent antibody techniques and, by 15 hr after infection, most contained nascent capsids lacking central dense cores. It is suggested that an error in DNA metabolism may be the primary cause of restriction. PMID- 4321914 TI - The interaction of closed circular DNA with intercalative dyes. 3. Dependence of the buoyant density upon superhelix density and base composition. PMID- 4321915 TI - Protein synthesis in Escherichia coli extracts programmed by poliovirus RNA. PMID- 4321916 TI - Triphosphoinositide phosphodiesterase in developing brain of the rat and in subcellular fractions of brain. PMID- 4321918 TI - The effect of histamines and other compounds on the formation of adenosine 3',5' monophosphate in slices from cerebral cortex. PMID- 4321917 TI - Effects of dopamine, gamma-aminobutyric acid and 5-hydroxytryptamine on incorporation of 32P into phosphatides in slices from the guinea pig brain. PMID- 4321920 TI - Bilateral traumatic abducens palsy. A mechanism of injury suggested by the study of associated cervical spine fractures. PMID- 4321919 TI - The influence of adrenergic and cholinergic blocking drugs on the glycogen content of the brain in rats deprived of paradoxical sleep. PMID- 4321921 TI - The choroid plexus in experimental hydrocephalus. A light and electron microscopic study in normal, hydrocephalic, and shunted hydrocephalic dogs. PMID- 4321922 TI - Oral reflections of infectious diseaes. 1. PMID- 4321923 TI - Camparison of electrical discharge with gamma-radiation for the production of free radicals in lyophilized proteins. PMID- 4321925 TI - Linkage group-chromosome correlation in Culex tritaeniorhynchus. AB - Linkage groups of a culicine mosquito, Culex tritaeniorhynchus, have been assigned to their respective chromosomes by genetic and cytologic observations of radiation-induced aberrations. Linkage group I is assigned to the smallest chromosome, linkage group II to the submetacentric chromosome, and linkage group III to the metacentric chromosome. PMID- 4321924 TI - [Trials of Synacthen in multiple sclerosis]. PMID- 4321926 TI - [Biochemistry of synapses]. PMID- 4321927 TI - Effects of ischaemia on content of metabolites in rat liver and kidney in vivo. AB - 1. The time-course of changes in content of intermediates of glycolysis in rat liver and kidney cortex after severance of blood supply was investigated. 2. The decline in content of ATP was more rapid in kidney (1.7-0.5mumol/g in 30s) than in liver (2.7-1.6mumol/g in 60s). In both tissues AMP and P(i) accumulated. 3. Net formation of lactate was 1.7mumol/g during the second minute of ischaemia in liver from well-fed rats, 1.1mumol/g in liver from 48h-starved rats, and about 1.0mumol/g during the first 30s of ischaemia in kidney. Net formation of alpha glycerophosphate was rapid, especially in liver. 4. In kidney the concentration of beta-hydroxybutyrate rose, but that of alpha-oxoglutarate and acetoacetate decreased. 5. In both organs the concentrations of fructose diphosphate and triose phosphates increased during ischaemia and those of other phosphorylated C(3) intermediates decreased. 6. The concentration of the hexose 6-phosphates rose rapidly during the first minute of ischaemia in liver, but decreased during renal ischaemia. 7. In kidney the content of glutamine fell after 2min of ischaemia, and that of ammonia and glutamate rose. 8. The redox states of the cytoplasmic and mitochondrial NAD couple in kidney cortex were similar to those in liver. 9. The regulatory role of glycogen phosphorylase, pyruvate kinase and phosphofructokinase is discussed in relation to the observed changes in the concentrations of the glycolytic intermediates. PMID- 4321928 TI - Preparation and characterization of the plasma membrane of pig lymphocytes. AB - Lymphocyte plasma membrane was isolated from minced pig mesenteric lymph node by differential centrifugation and by centrifuging through a sucrose density gradient. The yield of membrane was approx. 0.1% (dry wt. relative to wet wt. of lymph node). The purified material had a sucrose density of 1.14g/cm(3) and consisted mainly of smooth vesicles. The membrane fraction contained, apart from protein and lipid, 59mug of carbohydrate, 11mug of sialic acid and 28mug of RNA/mg of protein; no DNA was detected. The cholesterol/phospholipid molar ratio was 1.01. Specific activities (mumol of product/h per mg of protein) of 5' nucleotidase, succinate dehydrogenase, acid phosphatase and glucose 6-phosphatase were 10.1, 0, 0.51 and 0.30 respectively. The membrane vesicles were aggregated by an antiserum against pig lymphocytes and adsorbed the agglutinins to whole lymphocytes present in the antiserum; the membrane fraction was 28 times as effective as whole cells (on a dry wt. basis) in removing the lympho-agglutinins. Antisera against the membrane fraction agglutinated whole lymphocytes. It is concluded that the preparation represents the plasma membrane of small lymphocytes. The plasma membrane of pig thymocytes was isolated by using the same procedure. Its properties were similar to those of the lymphocyte plasma membrane. PMID- 4321930 TI - Cell-wall thickening in Bacillus subtilis. Comparison of thickened and normal walls. AB - 1. Incubation of Bacillus subtilis 168 trp in a glucose-amino acids-salts medium lacking tryptophan leads to an inhibition of cellular growth without affecting cell-wall synthesis. The cell walls increased approximately two- to three-fold in thickness and at the same time the amount of mucopeptide in the cells measured chemically increased to about the same extent. 2. Synthesis of mucopeptide and teichoic acid as measured by the extent of incorporation of radioactivity continued linearly for approximately 1h and then stopped. No reason was found for the strictly limited synthesis of the wall polymers. 3. The initial rates of incorporation of [(32)P]P(i) or [(3)H]alanine into teichoic acid and of (3)H labelled amino acids into mucopeptide were not appreciably inhibited by the addition of chloramphenicol to the glucose-amino acids-salts medium. 4. There was no selective turnover of the mucopeptide synthesized by the cells in a medium lacking tryptophan on resumption of growth in a complete medium. 5. Wall synthesis taking place during the thickening process was similar to normal wall synthesis proceeding in growing cells. Walls of different thicknesses prepared from cells incubated for various times in incomplete medium did not differ qualitatively in composition. The products of autolysis of thickened walls were isolated and the analyses indicated a close similarity in the details of their mucopeptide structure compared with the mucopeptide of cells growing in the exponential phase. PMID- 4321929 TI - The activity and kinetic properties of mevalonate kinase in superovulated rat ovary. AB - Methods are described for the assay and partial purification of mevalonate kinase from superovulated rat ovary. The total activity of mevalonate kinase in superovulated rat ovary was 1.6+/-0.14units/g wet wt.; it was unchanged by the administration of luteinizing hormone in vivo. The K(m) of a partially purified preparation of mevalonate kinase for dl-Mevalonate was 3.6+/-0.5mum; its K(m) for MgATP(2-) was 120+/-7.7mum. The enzyme was inhibited by geranyl pyrophosphate and farnesyl pyrophosphate, but not by isopentenyl pyrophosphate or 3,3' dimethylallyl pyrophosphate. dl-mevalonate 5-phosphate inhibited at high concentrations. With both geranyl pyrophosphate and farnesyl pyrophosphate the inhibition was competitive with respect to MgATP(2-). The K(i) for inhibition by geranyl pyrophosphate was 1.3+/-0.2mum; the K(i) for inhibition by farnesyl pyrophosphate was 1.0+/-0.3mum. These findings are discussed with reference to the control by luteinizing hormone of steroidogenesis from acetate. PMID- 4321931 TI - An effect of insulin on adipose-tissue adenosine 3':5'-cyclic monophosphate phosphodiesterase. AB - 1. 3':5'-Cyclic nucleotide phosphodiesterase activity was measured in homogenates prepared from epididymal fat-pads and isolated fat-cells incubated in the absence and presence of insulin. 2. Homogenates of insulin-treated tissues showed an increase in phosphodiesterase activity compared with controls. No effect of insulin was observed when the hormone was added directly to homogenates. 3. There was kinetic evidence for the presence of two 3':5'-cyclic nucleotide phosphodiesterases in adipose tissue. Insulin raised the maximal velocity of the low-K(m) enzyme and lowered the K(m) of the higher-K(m) enzyme. 4. It is suggested that the effect of insulin on adipose tissue phosphodiesterase accounts for the ability of this hormone to lower cyclic-AMP concentration in the tissue. PMID- 4321932 TI - Metabolism of angiotensin I in the pulmonary circulation. PMID- 4321935 TI - [Implication of hormonal treatment in the production of congenital malformations]. PMID- 4321933 TI - Some aspects of the kinetics of rat liver pyruvate carboxylase. AB - 1. The kinetics of rat liver pyruvate carboxylase were examined and the effect of various agents as activators or inhibitors determined. 2. Essentially similar results were obtained in comparisons of kinetics determined by a radioactivity method involving extracts of acetone-dried powders from whole livers and with a spectrophotometric assay using partially purified enzyme from the mitochondrial fraction. Activity per g of liver from fed or starved rats assayed under optimum substrate and activator conditions was 3 or 6 mumol of oxaloacetate formed/min at 30 degrees C, respectively. 3. The enzyme exhibited cold-lability and lost activity on standing, even in 1.5m-sucrose. 4. The K(m) towards pyruvate was about 0.33mm and towards bicarbonate 4.2mm. K(m) towards MgATP(2-) was 0.14mm. Mg(2+) ions activated the enzyme, in addition to their role in MgATP(2-) formation. From calculations of likely concentrations of free Mg(2+) in the assay medium a K(a) towards Mg(2+) of about 0.25mm was deduced. Mn(2+) also activated the enzyme as well as Mg(2+), but at much lower concentrations. It appeared to be inhibitory when concentrations of free Mn(2+) as low as 0.1mm were present. 5. Excess of ATP is inhibitory, and this appears at least in part independent of the trapping of Mg(2+). 6. Both Co(2+) and Zn(2+) were inhibitory; 2mol of the latter appeared to be bound even in the presence of excess of Mg(2+) and the inhibition was time-dependent. 7. Ca(2+) inhibited by competition with Mg(2+) (K(i) about 0.38mm). The inhibition due to Ca(2+) was less pronounced when activation was with Mn(2+). Inhibition by Ca(2+) and ATP appeared to be additive. 8. Hill plots suggested that no interactions occurred between ATP-binding sites. Although similar plots for total Mg(2+) gave n=3.6, no conclusions could be drawn due to the chelation of the cation with other components of the assay. Similar difficulties arose in assessing the values for Ca(2+). 9. The enzyme was inactive in the absence of acetyl-CoA and showed a sigmoidal response in its presence. K(a) was about 0.1mm with possibly up to four binding sites. Malonyl-CoA was a competitive inhibitor, with K(i) 0.01mm. 10. There was no apparent inhibition by glucose, glucose 6-phosphate, fructose 6-phosphate, fructose 1,6-diphosphate, acetoacetate, beta-hydroxybutyrate, malate, aspartate, pyruvate, palmitoylcarnitine, octanoate, glutathione, butacaine, triethyltin or potassium chloride under the conditions used. Inhibition was found with citrate (possibly by chelation) and adenosine, and also by phosphoenolpyruvate, AMP, ADP and cyclic AMP, K(i) towards the last four being 0.55, 0.76, 0.25 and 1.4mm respectively. PMID- 4321936 TI - [Blood bilirubin in the newborn after administration of estrogens to the mother near the end of gestation]. PMID- 4321934 TI - A comparison of the effects of diabetes induced with either alloxan or streptozotocin and of starvation on the activities in rat liver of the key enzymes of gluconeogenesis. AB - 1. Measurements of the activities in rat liver of the four key enzymes involved in gluconeogenesis, i.e. pyruvate carboxylase (EC 6.4.1.1), phosphoenolpyruvate carboxykinase (EC 4.1.1.32), fructose 1,6-diphosphatase (EC 3.1.3.11) and glucose 6-phosphatase (EC 3.1.3.9), have been carried out, all four enzymes being measured in the same liver sample. Changes in activities resulting from starvation and diabetes have been studied. Changes in concentration (activity/unit wet weight of tissue) were compared with changes in the hepatic cellular content (activity/unit of DNA). 2. Each enzyme was found to increase in concentration during starvation for up to 3 days, but only glucose 6-phosphatase and phosphoenolpyruvate carboxykinase showed a significant rise in content. Fructose 1,6-diphosphatase appeared to decrease in content somewhat during the early stages of starvation. 3. There was a marked increase in the concentration of all four enzymes in non-starved rats made diabetic with alloxan or streptozotocin, for the most part similar responses being found for the two diabetogenic agents. On starvation, however, the enzyme contents in the diabetic animals tended to fall, often with streptozotocin-treated animals to values no greater than for the normal overnight-starved rat. Deprivation of food during the period after induction of diabetes with streptozotocin lessened the rise in enzyme activity. 4. The results are compared with other published values and factors such as substrate and activator concentrations likely to influence activity in vivo are considered. 5. Lack of correlation of change in fructose 1,6 diphosphatase with the other enzymes questions whether it should be included in any postulation of control of gluconeogenic enzymes by a single gene unit. PMID- 4321937 TI - [Morphological and functional changes in the early human trophoblast under the action of intensive treatment by ACTH, cortisone or testosterone]. PMID- 4321938 TI - [Common necrotizing effect of ovarian and adrenocortical steroids on the rat placental trophoblast diminished of annihilated by injection of antagonist pairs of the same hormones]. PMID- 4321939 TI - [Treatment of trophoblastic tumors with methotrexate]. PMID- 4321940 TI - Fat embolism and hemolytic anemia. PMID- 4321941 TI - Trophoblast and its tumours in Ceylonese women. (A study of 431 cases). PMID- 4321942 TI - Cytochemical study of mucus & mucus secreting cells in epidermis of the earthworm, Pheretima elongata. PMID- 4321943 TI - Effect of CCC on growth & phosphatase activity. PMID- 4321944 TI - [Chronic nerve compression at the level of the upper limb. The value of electromyography and the measurement of motor conduction speed]. PMID- 4321946 TI - What you lose in hospital you gain on the district. PMID- 4321945 TI - Unilateral hyperlucent lung syndrome in children. PMID- 4321947 TI - Zoster, a recrudescence of VZ virus infection. PMID- 4321948 TI - [Antiproliferative and ncrosing action of adrenocortical and ovarian steroids on the invasive trophoblast of the placenta of the female rat]. PMID- 4321949 TI - [Internal therapy of peripheral arterial blood circulation disorders]. PMID- 4321950 TI - [Renal polycythemia as a facultative leading symptom in kidney tumors, hydronephrosis ad cystic kidney]. PMID- 4321951 TI - Characterization of the less-reactive SH groups of D-glyceraldehyde-3-phosphate dehydrogenase. II. Effect of coenzyme, anions and pH on the reactivity. PMID- 4321952 TI - Identification of 1-dimethylamino-naphthalene-5-sulfonyl amino acids by thin layer electrophoresis. PMID- 4321953 TI - [Masculinizing tumors of the ovaries]. PMID- 4321954 TI - [Studies of sex chromatin in tumors of female genitalia. (Review or literature)]. PMID- 4321955 TI - Hypoglycemia in children. Relationship between adrenocortical function and growth. PMID- 4321956 TI - Total prolonged drug-induced REM sleep suppression in anxious-depressed patients. PMID- 4321957 TI - Chlorpromazine and sleep in psychiatric patients. PMID- 4321958 TI - [Autoradiographic examinations of the metabolic activity of the carotid body]. PMID- 4321959 TI - [Malignant tumors of the external ear]. PMID- 4321960 TI - 13C studies on flavin free radicals. PMID- 4321961 TI - Renal gluconeogenesis: effects of parathyroid hormone and dibutyryl 3',5'-AMP. PMID- 4321962 TI - Occurrence of 3-O-methylmannose in lipopolysaccharides of Klebsiella and Escherichia coli. PMID- 4321963 TI - Renal gluconeogenesis: effects of Ca2+ and H+. PMID- 4321964 TI - The role of ATP in the effect of glucose on the excess porphyrin biosynthesis. PMID- 4321965 TI - Increase of NAD glycohydrolase activity and decrease of NAD concentration in rat liver during fasting. PMID- 4321966 TI - The regulation of glycogen metabolism in mouse liver. PMID- 4321967 TI - O-phsphoserine as a hydrolysis product and amino acid analysis of shells of new laid eggs of the house cricket, Acheta domesticus L. PMID- 4321968 TI - Modulation of afferent transmission in the lemniscal system during voluntary movement in cat. PMID- 4321969 TI - Observations on the management of salivary gland tumors. PMID- 4321970 TI - Mammography and diseases of the breast. PMID- 4321971 TI - The present status of mammary thermography. PMID- 4321972 TI - Heterogeneity of strain R avian (erythroblastosis) virus. PMID- 4321973 TI - Difference in electrokinetic charge of cells between two cell types of ascites hepatoma after removal of sialic acid. PMID- 4321974 TI - Incidence of EB virus-containing cells in primary and secondary clones of several Burkitt lymphoma cell lines. PMID- 4321975 TI - Two enzymes of serine metabolism in rat liver and hepatomas. PMID- 4321976 TI - Change of glycolipid pattern in Morris hepatomas 5123 and 7800. PMID- 4321978 TI - [Viral factor stimulating excess cell growth]. PMID- 4321977 TI - Structure of the glycine-rich, arginine-rich histone of the Novikoff hepatoma. PMID- 4321979 TI - Interaction of fetal disease and the onset of labor in cattle and sheep. PMID- 4321980 TI - Virus infections and malformations. PMID- 4321981 TI - Formation of methionine methyl groups. PMID- 4321982 TI - The effect of cyclic AMP on th heart rate of the isolated rat atria. PMID- 4321983 TI - Review on the interaction of catecholamines and other hormonal stimulations. PMID- 4321984 TI - The etiopathology of hypertension. PMID- 4321985 TI - Immunologically induced aspermatogenesis in the white mouse. II. PMID- 4321986 TI - [Scientific report from the 27th congress: speech disorders in peripheral neurologic disorders]. PMID- 4321987 TI - Surveillance of poliomyelitis in Czechoslovakia in 1966-1968. PMID- 4321988 TI - Experiences with a new combined vaccine against B. parapertussis, diphtheria, tetanus and B. pertussis employed in a field trial in Prague 10. PMID- 4321989 TI - The ultrastructure of the adrenal cortex of the rat under normal and experimental conditions. PMID- 4321990 TI - [Cytodiagnosis of lung diseases]. PMID- 4321991 TI - [On the usefulness of exploring enzymatic activities in prostatic carcinomas]. PMID- 4321992 TI - [Fibrinolytic activity in brain tumors]. PMID- 4321993 TI - [Search of human leukemia viruses]. PMID- 4321995 TI - [A case of IgA myelomatosis]. PMID- 4321994 TI - [Enzymatic activities of liver and adipose tissue during total fasting or protein fasting and subsequent equilibrium refeeding]. PMID- 4321996 TI - [Valvular prostheses during the acute stage of bacterial endocarditis]. PMID- 4321998 TI - [Clinical aspects of trophoblastic tumors]. PMID- 4321997 TI - Clinical evaluation of hormone therapy in the agalactia syndrome of sows. PMID- 4321999 TI - [Co-occurrence of cervix carcinoma and chorioepithelioma]. PMID- 4322000 TI - Paget's disease of the vulva--a cytogenetic study of skin fibroblasts, tumor cells, andpperipheral blood leukocytes in culture. PMID- 4322001 TI - Non-photochromogenic mycobacteria serotype Davis. The inhomogeneity within the serological group and the relationship to Mycobacterium avium. PMID- 4322002 TI - [Studies on the effect of vibration on the thyroid gland function]. PMID- 4322003 TI - Nervous and myogenic mechanisms in the control of a vascular neuroeffector system. PMID- 4322004 TI - The syndrome of testicular feminization. PMID- 4322005 TI - Experience with electron microscopy in the differential diagnosis of smallpox. AB - The usefulness of negative-contrast electron microscopy in the rapid differential diagnosis of poxvirus and herpesvirus exanthems is described in this study of 301 specimens from patients with vesicular exanthematous diseases. Specimens from patients with smallpox, various forms of vaccination complications, varicella, zoster (shingles), and herpes simplex are included in this evaluation. Electron microscopy, when applied to the study of lesion material, was found to be more sensitive than the classical techniques of virus isolation in the diagnosis of both poxvirus and herpes/varicella virus infections. However, since specific identification of a virus within a group cannot be made morphologically by electron microscopy, it is recommended that both electron microscopy and virus isolation methods be employed for the routine differential diagnosis of vesicular exanthematous diseases in the reference diagnostic laboratory. PMID- 4322007 TI - What is the current status of the viral zoonoses? PMID- 4322006 TI - The environmental distribution of canine respiratory tract neoplasms. PMID- 4322008 TI - Corticotropin therapy and thymectomy in management of myasthenia gravis. PMID- 4322009 TI - [Metabolism of isolated human adipose cells in vitro. II. Regulation of lipolysis]. PMID- 4322010 TI - Fine-needle aspiration biopsy for cytodiagnosis of malignant tumour in the liver. PMID- 4322011 TI - A new pharmacologic phonocardiography by the use of angiotensin. PMID- 4322012 TI - [Epilepsy and similar disorders from the viewpoint of an EEG-department and seizure-consultations in a pediatric clinic]. PMID- 4322013 TI - Stimulation of adrenal cholesterol uptake from plasma by adrenocorticotrophin. PMID- 4322015 TI - [Pharmacokinetics and pharmacokinetic studies with carbenicillin]. PMID- 4322014 TI - [Bacterial content of the extirpated appendix and extirpated gallbladder following directed antibiotic therapy]. PMID- 4322016 TI - Inhibition of steroid 3-sulfatase by endogenous steroids. A possible mechanism controlling placental estrogen synthesis from conjugated precursors. PMID- 4322018 TI - [Localized cooling of the feline red nucleus. Blockage of relayed responses and absence of action upon passage fibers]. PMID- 4322017 TI - [Glucose metabolism of the placenta: activities of gluconeogenic enzymes in human villous tissue]. PMID- 4322020 TI - [Study of sleep in C57BR-cd and CBA mice]. PMID- 4322019 TI - [Behavior and somato-vegetative peculiarities of sleep states in Equidae (Equus caballus) and bovines (Bos taurus)]. PMID- 4322021 TI - A heat labile mercaptoethanol susceptible homocytotropic antibody in the guinea pig. PMID- 4322023 TI - [2 cases of malignant synoviomas in children]. PMID- 4322022 TI - Effect of trypsin on morphological integrity and some functional activities of mitochondria from normal liver and AH-130 Yoshida ascites hepatoma. PMID- 4322024 TI - Mechanism of carcinogenesis by RNA tumor viruses. 3. Formation of RNA, DNA complex and duplex DNA molecules by the DNA polymerase (s) of avian myeloblastosis virus. AB - DNA polymerase activity can be unmasked in avian myeloblastosis virus (AMV) by treatment with the nonionic detergent Nonidet P-40. Two products are formed: (1) RNA.DNA hybrid molecules and (2) duplex DNA molecules. The kinetics of dTTP incorporation into DNA are biphasic: an initial rapid reaction for 4 min at 37 degrees C with a minimal polymerization rate of 10-20 nucleotides per see, and a second reaction at about half the initial rate. Viral RNA.DNA complexes are detected as early as 30 sec after the initiation of DNA synthesis; DNA free of template is formed subsequently. Most of the free AMV DNA forms an RNA.DNA hybrid when annealed with viral RNA. Over half of the free AMV DNA product is inferred to be double-stranded, since it is retained on hydroxyapatite columns after elution with 0.12 M phosphate buffer, and is resistant to Escherichia coli exonuclease I. Adenovirus or calfthymus DNA added to unmasked AMV stimulates DNA synthesis 4-16 times if there is no treatment with RNase, and 40-130 fold if RNase treatment precedes the enzyme assay. It is possible that two polymerases are present, or that a single enzyme forms both the RNA.DNA hybrid and the double stranded product. PMID- 4322026 TI - The pituitary-adrenal system and the developing brain. PMID- 4322025 TI - A specific competitive inhibitor of angiotensin II. AB - A peptide analog, [4-phenylalanine, 8-tyrosine]-angiotensin II, was prepared by solid phase peptide synthesis and its structure confirmed. The compound was found to be a potent inhibitor of angiotensin II in vitro (isolated rat uterus strips) and in vivo (rat blood pressure). The analog was found to be highly specific and did not inhibit the action of a number of other peptides and spasmogenic compounds. PMID- 4322027 TI - [Preliminary results in myeloradiculography without rachianesthesia]. PMID- 4322029 TI - [Value of coeliac (hepatic) arteriography in the detection of arteriovenous fistulae and hepatomas]. PMID- 4322028 TI - [Taurine and the cardiovascular system]. PMID- 4322030 TI - [Role of the acetylcholine system in excitation conduction]. PMID- 4322031 TI - [Structural characteristics and mechanism of formation of biliary calculi]. PMID- 4322032 TI - [Mediastinal neoplasms and cysts in children]. PMID- 4322033 TI - [The diagnostic value of the cisternography in acoustic neuroma]. PMID- 4322034 TI - [Studies on the respiratory form of rhinopneumonitis in adult horse]. PMID- 4322035 TI - [Occurrence of neutralizing antibodies against equine rhinovirus (strain NM 11) in horse stocks in Berlin]. PMID- 4322036 TI - [Rachitic scoliosis in tupaias]. PMID- 4322038 TI - Effet of prostaglandin E1 alone and in combination with theophylline or aspirin on collagen-induced platelet aggregation and on platelet nucleotides including adenosine 3':5'-cyclic monophosphate. AB - 1. Human platelet nucleotides were labelled by incubating platelet-rich plasma with [U-(14)C]adenine. With such platelets, the effects of prostaglandin E1, theophylline and aspirin were determined on collagen-induced platelet aggregation and release of platelet ATP and ADP. Intracellular changes of platelet radioactive nucleotides, particularly 3':5'-cyclic AMP, were also determined both with and without collagen treatment. 2. Prostaglandin E1, theophylline and aspirin inhibited collagen-induced aggregation of platelets in a dose-dependent manner. Collagen-induced release of ATP and ADP and breakdown of radioactive ATP were also inhibited in a dose-dependent manner. 3. Prostaglandin E1 stimulated the formation of platelet radioactive 3':5'-cyclic AMP in a dose-dependent manner. With a given dose of prostaglandin E1, maximum formation of radioactive 3':5'-cyclic AMP occurred by 10-30s and thereafter the concentrations declined. The degree of inhibition of aggregation produced by prostaglandin E1, however, increased with its time of incubation in platelet-rich plasma before addition of collagen, so that there was an inverse relationship between the radioactive 3':5' cyclic AMP concentration measured at the time of collagen addition and the subsequent degree of inhibition of aggregation obtained. 4. Neither theophylline nor aspirin at a concentration in platelet-rich plasma of 1.7mm altered platelet radioactive 3':5'-cyclic AMP contents. In the presence of prostaglandin E1, theophylline increased the concentration of radioactive 3':5'-cyclic AMP over that noted with prostaglandin E1 alone, but aspirin did not. 5. Mixtures of prostaglandin E1 and theophylline had a synergistic effect on inhibition of platelet aggregation. The same was true to a lesser extent with mixtures of prostaglandin E1 and aspirin. Such mixtures also inhibited collagen-induced release of platelet ATP and ADP and breakdown of platelet radioactive ATP. 6. Certain concentrations of either theophylline or aspirin and mixtures of small concentrations of prostaglandin E1 with either theophylline or aspirin caused little or no increase of radioactive 3':5'-cyclic AMP at the time of collagen addition, but inhibited aggregation to a marked degree, whereas higher concentrations of prostaglandin E1 alone caused a much greater increase of radioactive 3':5'-cyclic AMP at the time of collagen addition but inhibited aggregation to a lesser extent. With these compounds there does not appear to be a correlation between these parameters. PMID- 4322039 TI - Kinetic studies of formate dehydrogenase. AB - 1. The kinetic mechanism of formate dehydrogenase is a sequential pathway. 2. The binding of the substrates proceeds in an obligatory order, NAD(+) binding first, followed by formate. 3. It seems most likely that the interconversion of the central ternary complex is extremely rapid, and that the rate-limiting step is the formation or possible isomerization of the enzyme-coenzyme complexes. 4. The secondary plots of the inhibitions with HCO(3) (-) and NO(3) (-) are non-linear, which suggests that more than one molecule of each species is able to bind to the same enzyme form. 5. The rate of the reverse reaction with carbon dioxide at pH6.0 is 20 times that with bicarbonate at pH8.0, although no product inhibition could be detected with carbon dioxide. The low rate of the reverse reaction precluded any steady-state analysis as the enzyme concentrations needed to obtain a measurable rate are of the same order as the K(m) values for NAD(+) and NADH. PMID- 4322037 TI - The use of zonal centrifugation to study membrane formation during the life cycle of mammalian cells. Synthesis of 'marker' enzymes and other components of cellular organelles. AB - 1. The activity of enzymes characteristic of microsomes (NADPH-cytochrome c reductase and uridine diphosphatase) and of inner mitochondrial membranes (cytochrome c oxidase and succinate-cytochrome c reductase) increases during the cell cycle of P815Y neoplastic mast cells in concert with total protein. The activity of glutamate dehydrogenase, an enzyme of the mitochondrial matrix, increases in a somewhat different manner. 2. The specific activity of mitochondrial structures involved in energy-coupling measured with a fluorescent probe remains constant during the cell cycle. 3. Mitochondrial and microsomal protein increases during the cycle at the same time as total protein; nuclear protein increases rather more sharply. 4. The rate of incorporation of labelled choline or inositol into nuclear, mitochondrial or microsomal phospholipid during the cell cycle follows the rate of incorporation into total phospholipid. 5. It is concluded that the major components of cellular membranes are synthesized, like total protein or phospholipid, throughout most of the intermitotic period. PMID- 4322040 TI - The action of ranatensin, a new polypeptide from amphibian skin, on the blood pressure of experimental animals. AB - 1. The blood pressure response to ranatensin, an undecapeptide from the skin of the frog, Rana pipiens, has been studied in various experimental animals.2. Ranatensin raised blood pressure in the dog and rabbit. The response was not altered by atropine, phentolamine, propranolol or hexamethonium, suggesting a direct peripheral vasoconstrictor action. In both animals ranatensin was about one-tenth as potent as angiotensin. Tachyphylaxis to ranatensin did occur, but there was no cross-tachyphylaxis with angiotensin, bradykinin, or noradrenaline.3. The peptide lowered blood pressure in the monkey, being as potent as eledoisin. The response was not altered by atropine, phentolamine, propranolol, tripelennamine, tetraethylammonium, bretylium, or methysergide. This again suggests a direct peripheral action on vascular smooth muscle. There was no tachyphylaxis to the depressor action, nor was there cross-tachyphylaxis with angiotensin, eledoisin, bradykinin, or noradrenaline.4. Ranatensin did not alter the blood pressure in cats and had a variable action in the guinea-pig with a rapid onset of tachyphylaxis.5. Ranatensin has a variable effect on the blood pressure in the rat that is related to the basal level of blood pressure. When the blood pressure is high, the response to the peptide is hypotension. Ranatensin raises blood pressure in the rat when the basal blood pressure is low. The pressor response to ranatensin appears to be due, in part, to the release of noradrenaline from peripheral sympathetic nerve endings.6. The composite action of ranatensin on blood pressure of various experimental animals is unlike that of any other peptide. Its hypertensive action in the dog or rabbit, together with a potent hypotensive action in the monkey, readily distinguishes it from all other vasoactive peptides. PMID- 4322041 TI - Evidence that adenosine triphosphate or a related nucleotide is the transmitter substance released by non-adrenergic inhibitory nerves in the gut. AB - 1. Stimulation of the vagal non-adrenergic inhibitory innervation caused the release of adenosine and inosine into vascular perfusates from the stomachs of guinea-pigs and toads.2. Stimulation of portions of Auerbach's plexus isolated from turkey gizzard caused the release of adenosine triphosphate (ATP), adenosine diphosphate (ADP) and adenosine monophosphate (AMP).3. ATP, added to solutions perfused through the toad stomach vasculature, was broken down to adenosine, inosine and adenine.4. Of a series of purine and pyrimidine derivatives tested for inhibitory activity on the guinea-pig isolated taenia coli, ATP and ADP were the most potent.5. ATP caused inhibition of twelve other gut preparations previously shown to contain non-adrenergic inhibitory nerves. The inhibitory action of ATP was not prevented by tetrodotoxin.6. Quinidine antagonized relaxations of the guinea-pig taenia coli caused by catecholamines or adrenergic nerve stimulation. Higher concentrations of quinidine antagonized relaxations caused by ATP or non-adrenergic inhibitory nerve stimulation.7. When tachyphylaxis to ATP had been produced in the rabbit ileum, there was a consistent depression of the responses to non-adrenergic inhibitory nerve stimulation but not of responses to adrenergic nerve stimulation.8. It is suggested that ATP or a related nucleotide is the transmitter substance released by the non-adrenergic inhibitory innervation of the gut. PMID- 4322042 TI - Recovery of hypothalamo-pituitary-adrenal function in the rat after prolonged treatment with betamethasone. AB - 1. Betamethasone caused growth retardation, adrenal atrophy and impaired hypothalamo-pituitary-adrenal (HPA) activity in the rat.2. In spite of the profound impairment, recovery of normal HPA function was rapid, but the growth retardation persisted.3. The ability of the pituitary gland to secrete basal corticotrophin (ACTH), recovered more rapidly and the adrenocorticotrophic response to stress less rapidly than the ability of the adrenal cortex to respond to ACTH.4. The degree of HPA suppression was not determined by the total dose of steroid.5. The possible significance of the results is discussed. PMID- 4322043 TI - The relationship between the level of cholinesterase in plasma and the action of suxamethonium in animals. AB - 1. The neuromuscular blocking action of suxamethonium, given by intravenous injection, and the effect upon it of iso-OMPA (tetraisopropyl pyrophosphoramide) in doses which produced marked selective inhibition of cholinesterase in blood were studied in anaesthetized rats and cats, and in mice.2. In cats experiments were also carried out in which suxamethonium was given by intravenous infusion until an effect which remained constant with time was achieved. From the degree of neuromuscular block (under equilibrium conditions) obtained with different infusion rates the infusion rate for 50% reduction in twitch tension of the indirectly stimulated soleus and gastrocnemius muscles (IR50) was calculated. The effect on it of raising the suxamethonium hydrolysing capacity of blood and of selectively reducing the level of cholinesterase in blood by various doses of iso OMPA was then investigated.3. At relevant stages of each experiment cholinesterase activity in blood was determined with butyrylcholine or benzoylcholine and where appropriate with suxamethonium as substrate.4. The results obtained show that in rats and cats the effectiveness of suxamethonium is unrelated to the level of cholinesterase activity in blood and that raising the suxamethonium hydrolysing capacity in the blood up to 22-fold (in cats) only reduces the IR50 by a factor of 1.6.5. The enhancement of the effectiveness of suxamethonium in the three species (2- to 3-fold in rats, 2- to 4-fold in mice and 7- to 8-fold in cats under the conditions used for comparison) which follows the administration of iso-OMPA is attributable to inhibition of cholinesterase in the tissues.6. It is concluded that the results obtained clearly indicate that the species studied do not give information as regards suxamethonium and its metabolism which is applicable to man. PMID- 4322045 TI - [Experimental pathogenicity of a strain of Herpesvirus bovis for neonate calves inoculated by aerosol]. PMID- 4322044 TI - Role of noradrenaline in the acute pressor response to angiotensin in conscious cats. AB - The changes in the pressor responses to angiotensin after treatment with substances known to modify sympathetic function have been compared with the changes in the responses to noradrenaline, tyramine and McN-A-343 using conscious cats. The responses to angiotensin were not reduced by blockade of adrenergic neurones, alpha and beta-adrenoceptors, or of autonomic ganglia. In conscious cats the acute pressor response to angiotensin does not appear to be related directly to stimulation or facilitation of transmission in sympathetic ganglia or to release of catecholamines from tissue stores. PMID- 4322046 TI - [Therapeutic indications in acromegaly]. PMID- 4322047 TI - Immobilization stress induced changes in adrenocortical and medullary cyclic AMP content in the rat. PMID- 4322048 TI - Corticotrophin release induced by E. coli endotoxin after removal of the medial hypothalamus. PMID- 4322049 TI - Unique estrogen-binding properties of rat pregnancy plasma. PMID- 4322050 TI - Immunological and biological activity of HCG following progressive desialylation. PMID- 4322052 TI - Testosterone and cortisol concentration in spermatic, adrenal and systemic venous blood in adult male guinea pigs. PMID- 4322051 TI - Effect of ACTH on corticosteroidogenesis and adenyl cyclase activities in the rat adrenal tissue. PMID- 4322053 TI - [New concepts on the physiology of sleep: the natural sleep]. PMID- 4322055 TI - [Stimulation of the catabolism of reserve materials in starved yeast by alcohols and other agents]. PMID- 4322054 TI - [Assignment of an essential histidine residue to the substrate binding site of lactate dehydrogenase]. PMID- 4322056 TI - Isolation and purification of alpha-1-acid glycoprotein from human liver. PMID- 4322057 TI - [Recent progress in endocrinology]. PMID- 4322058 TI - [Recent progress in the study of diabetes mellitus]. PMID- 4322059 TI - Effect of angiotensin on the kidney of the high altitude native. PMID- 4322060 TI - [On an epidemic episode of acute respiratory disease due to Echo-1 virus in a children's community]. PMID- 4322061 TI - [Value of passive hemagglutination tests in the seroepidemiology of pertussis]. PMID- 4322062 TI - Comparison of electronystagmographic recordings in patients with vertigo and Parkinson's disease. PMID- 4322063 TI - Giant-cell arteritis. Horton-Magath-Brown temporal arteritis, cranial arteritis. PMID- 4322065 TI - Effects of smoking on lung structure of appalachian coal workers. PMID- 4322064 TI - The stimulation by maleate of alpha-oxoglutarate exit from rat liver mitochondria. PMID- 4322066 TI - Emphysema and pneumoconiosis. A comparative quantitation of dust content of pneumoconiotic rodent lungs with and without emphysema. PMID- 4322067 TI - [Ferritin labeled antibodies and their use in experimental cancer research]. PMID- 4322068 TI - An assessment of massive-dose chemotherapy of malignant disease. PMID- 4322069 TI - Acetylcholine and functional vasodilatation in the submaxillary gland of the cat. PMID- 4322070 TI - Central effects of clonidine (2-(2,6-dichlorophenylamino)-2-imidazoline hydrochloride, St 155) upon thermoregulation in the sheep and goat. PMID- 4322071 TI - The effect of 1-trans-delta 9-tetrahydrocannabinol on the hypothalamo-hypophyseal adrenal axis of rats. PMID- 4322072 TI - Isolation and characterization of hybrids between mouse and Chinese hamster cell lines. PMID- 4322073 TI - Ultrastructure of liver cell carcinoma in Macaca mulata monkey. PMID- 4322074 TI - Circulatory reflex response in diabetic patients with or without peripheral neuropathy. PMID- 4322075 TI - Glomus-cell tumors in the lower extremity. Report of two cases. PMID- 4322076 TI - Nerve-root entrapment in "traumatic" extradural arachnoid cyst. PMID- 4322077 TI - Delayed sciatic-nerve entrapment following the use of self-curing acrylic. A case report. PMID- 4322078 TI - Human lymphocytic metabolism. Effects of cyclic and noncyclic nucleotides on stimulation by phytohemagglutinin. AB - The effects of extracellular nucleotides and agents which elevate intracellular cyclic adenosine 3',5'-monophosphate (cyclic AMP) concentrations on human lymphocyte metabolism have been studied. Aminophylline, isoproterenol, and prostaglandins, all of which elevate lymphocyte cyclic AMP levels, inhibited incorporation of (3)H-labeled thymidine, uridine, and leucine into the DNA, RNA, and protein of phytohemagglutinin (PHA)-stimulated lymphocytes. Aminophylline inhibition was maximal only when the inhibitor was added within 1 hr after exposure of cells to PHA, suggesting that a relatively early step in the lymphocyte transformation process may be affected. The addition of various nucleotides to the culture medium also inhibited incorporation of labeled precursors. The best inhibitor, dibutyryl cyclic AMP (DU cyclic AMP), produced maximal inhibition only if present during the 1st hr after initial exposure to PHA. Among the various cyclic nucleotides derivatives of guanosine and adenine were the most effective inhibitors (substantial inhibition at 0.1 mM concentrations). However, the inhibition was not specific for nucleotides containing the cyclic phosphodiester moiety since the tri-, di-, and monophosphates of adenosine and guanosine were equally effective in diminishing thymidine uptake. The above inhibitions were not due to secondary effects of the inhibitors on the interaction of PHA with lymphocytes as judged by (125)I-labeled PHA binding studies.Low concentrations (1-10 mumoles/liter) of cyclic AMP produced slight stimulation of thymidine-(3)H uptake in resting lymphocytes (lymphocytes not stimulated with PHA). However, the effects were quite small as compared with those produced by PHA itself. Attempts to demonstrate increased thymidine uptake 48 hr after pulsing lymphocytes with aminophylline or isoproterenol were unsuccessful. The relationship of these observations to a possible regulatory role for cyclic AMP in PHA-stimulated lymphocytes is discussed. PMID- 4322079 TI - Electrophoretic distribution of the proteins and glycoproteins of influenza virus and Sendai virus. AB - The proteins of influenza (WSN) and Sendai virus have been separated by polyacrylamide gel electrophoresis into five components. In both cases, three of these components were shown to be glycoproteins containing fucose, galactose, and glucosamine. Two protein components of each virus were probably free from these sugar residues, including the structural unit of the viral ribonucleoprotein (molecular weight of about 60,000 daltons). PMID- 4322080 TI - Changes in deoxyribonucleic acid synthesis regulation in Chinese hamster cells infected with simian virus 40. AB - Infection of primary or secondary cultures of Chinese hamster embryo cells with simian virus 40 at a multiplicity of 20 to 50 induced synthesis of the virus specific intranuclear T antigen in 80 to 90% of the cells within 48 to 72 hr. In the infected cultures, 30 to 50% more cells were recruited into deoxyribonucleic acid (DNA) synthesis than in the controls, whether or not the cultures were confluent. The newly synthesized DNA was mostly cellular, since little virus was produced (as shown by various techniques: immunofluorescence for viral antigen, virus growth curves, and isolation of viral DNA from infected cultures). Transformed cells could be detected a few weeks after infection and produced tumors when inoculated into irradiated animals. Chromosomal changes were observed soon after infection (24 hr). Initially, there was a marked increase in the proportion of polyploid cells (8 to 14%), most of which were chromosomally normal. In a few weeks, a large majority of the infected population was polyploid (30 to 50%). Thus, the polyploid cells have the ability to proliferate. Evidence is presented to suggest that polyploid cells arise by stimulation of cells in the G(1), G(2), or S phases to undergo two or more successive periods of DNA synthesis without an intervening mitosis. With a subsequent loss or redistribution of chromosomal material, this may lead eventually to a biologically transformed cell; thus, it is suggested that the initial event(s) relevant to transformation occurs at the level of control of cellular DNA synthesis. PMID- 4322081 TI - Adenovirus type 2-simian virus 40 hybrid population: evidence for a hybrid deoxyribonucleic acid molecule and the absence of adenovirus-encapsidated circular simian virus 40 deoxyribonucleic acid. AB - The deoxyribonucleic acid (DNA) from the adenovirus-encapsidated particles of the adenovirus type 2 (Ad2)-simian virus 40 (SV40) hybrid population plaque variant (Ad2(++) HEY), known to yield SV40 virus with high efficiency, was studied by equilibrium density centrifugation followed by ribonucleic acid-DNA hybridization employing virus-specific complementary ribonucleic acids synthesized in vitro. These techniques establish linkage between the Ad2 and SV40 components in the adenovirus-encapsidated particles of this population. The linkage is alkali resistant and presumably covalent; thus, the Ad2 DNA and SV40 DNA are present in a hybrid molecule. Velocity centrifugation studies in alkaline sucrose gradients eliminated the possibility that supercoiled circular SV40 DNA is present in the adenovirus capsids. The DNA obtained from the adenovirus-encapsidated particles of the Ad2(++) HEY population appears to consist of nonhybrid Ad2 DNA and Ad2 SV40 hybrid DNA molecules. PMID- 4322082 TI - Relative antiviral resistance induced in homologous and heterologous cells by cross-reacting interferons. AB - Human cells incubated with human interferon become more resistant to vesicular stomatitis virus (VSV) than to Semliki Forest virus (SFV); monkey cells treated with monkey interferon become more resistant to SFV than to VSV. However, monkey cells incubated with human interferon developed relative antiviral activity identical to that induced by homologous interferon, and human cells developed characteristic human interferon-induced relative antiviral activity when exposed to monkey interferon. Therefore, cross-reacting interferons induce the relative antiviral activity characteristic of the interferon-treated cell rather than the cell of the interferon's origin. This relationship supports the hypothesis that interferon is not itself antiviral but rather induces cells to develop their own antiviral activity. PMID- 4322085 TI - Enzyme regulation in gluconeogenesis and lipogenesis. Relationship of protein synthesis and cyclic AMP to lipolytic action of growth hormone and glucocorticoids. PMID- 4322084 TI - Isolation and characterization of a double-stranded ribonucleic acid from Penicillium chrysogenum. AB - Double-stranded ribonucleic acid has been obtained from cells of the fungus Penicillium chrysogenum. This ribonucleic acid appears to be associated with mycophage and is an efficient inducer of interferon Its. extraction and partial purification are discussed, and evidence for its double-stranded and ribosidal nature is reviewed. The implications of viral nucleic acid in the life processes of fungi are considered. PMID- 4322083 TI - Effect of mengovirus replication on choline metabolism and membrane formation in novikoff hepatoma cells. AB - Infection of Novikoff rat hepatoma cells (subline NlSL-67) with mengovirus resulted in a two- to threefold increase in the rate of choline incorporation into membrane phosphatidylcholine at about 3 hr after infection, without affecting the rate of transport of choline into the cell or its phosphorylation. The time course of virus-stimulated phosphatidylcholine synthesis was compared with the time courses of other virus-induced processes during a single cycle of replication. The formation of viral ribonucleic acid (RNA) polymerase and of viral RNA commenced about 1 hr earlier than the virus-stimulated choline incorporation. Further, isopycnic centrifugation of cytoplasmic extracts indicated that the excess of phosphatidylcholine synthesized by infected cells is not located in the membrane structures associated with the viral RNA replication complex, but with structures of a lower density (1.08 to 1.14 g/cc). These membrane structures probably represent the smooth vesicles which accumulate in the cytoplasm of infected cells during the period of increased phosphatidylcholine synthesis between 3 and 5 hr after infection. They are formed with both newly synthesized phosphatidylcholine and phosphatidylcholine present prior to infection. However, concomitant protein synthesis is not required for the stimulated synthesis of membranes; the effect was not inhibited by treating the cells with inhibitors of protein synthesis at 3 hr after infection, although virus production was inhibited about 90% and virus-induced cell degeneration was markedly reduced and delayed. Production of mature virus began normally at about the same time as the stimulation of phosphatidylcholine synthesis. Treatment of infected cells with puromycin at 2 hr, on the other hand, completely inhibited the stimulation of phosphatidylcholine synthesis. PMID- 4322086 TI - Interrelationships between malate-aspartate shuttle and citric acid cycle in rat heart mitochondria. PMID- 4322087 TI - Possible regulatory factors for pyruvate carboxylase with particular reference to enzyme from chicken liver. PMID- 4322088 TI - [The effect of aflatoxin B1 on the cytochemically detectable activity of various enzymes of Mucor hiemalis (Mucorales)]. PMID- 4322089 TI - Pigment formation in the dermatophytes. PMID- 4322090 TI - Nature of ribonuclease-resistant nucleic acid of chick embryo cells transformed by Schmidt-Ruppin strain of Rous Sarcoma Virus. PMID- 4322091 TI - Concentration of cyclic adenosine 3',5'-monophosphate in human leucocytes during phagocytosis. PMID- 4322092 TI - Cyclic AMP in metabolism. PMID- 4322093 TI - [Passive smkers. On harmful effects of cigarette smoke inhaled by non-smokers]. PMID- 4322094 TI - Functioning adrenocortical carcinoma. Case report. PMID- 4322095 TI - Modern views on pharmacology. I. Receptors. PMID- 4322096 TI - Application of a light-scattering aerosol counter and a four-stage impactor to industrial hygiene air sampling. PMID- 4322097 TI - Electron microscope studies of frozen-substituted marine eggs. II. Morphology of ice crystal-free unfertilized eggs. PMID- 4322098 TI - Electron microscope studies of frozen-substituted marine eggs. I. Conditions for avoidance of intracellular ice crystallization. PMID- 4322099 TI - Electron microscope studies of frozen-substituted marine eggs. 3. Structure of the mitotic apparatus of the first meiotic division. PMID- 4322100 TI - The opisthonephric kidney of the sea lamprey of the Great Lakes, Petromyzon marinus L. 3. Intermediate, distal, and collecting segments of the ammocoete. PMID- 4322101 TI - Composition and synthesis of DNA in synchronously growing cells of Chlorella pyrenoidosa. PMID- 4322103 TI - A case of fulminating amoebiasis. PMID- 4322104 TI - Cation-induced organization changes in a lipid bilayer model membrane. PMID- 4322105 TI - Initiator tRNA for the synthesis of globin peptides. PMID- 4322106 TI - Regulation of citrate synthase activity in strict and facultatively autotrophic Thiobacilli. PMID- 4322107 TI - Opposite effects of cyclic AMP and its dibutyryl derivative on glycogen levels in HeLa cells. PMID- 4322108 TI - Loss of cyclic 3'5'-AMP dependent kinase and reduction of phosphorylase kinase in skeletal muscle of a girl with deactivated phosphorylase and glycogenosis of liver and muscle. PMID- 4322109 TI - [Synaptic reactions of sensory-motor cortex neurons to direct cortical stimulation]. PMID- 4322110 TI - [Comparative fat-mobilizing acitivty of some pituitary hormones and Adipozin]. PMID- 4322111 TI - [Effect of morphine on the activity of neuronal elements of the dorsal region of the spinal cord dorsal horn]. PMID- 4322112 TI - [Demonstration of a serological difference between the virus adapted to Drosophila and the initial strain of the vesicular stomatitis virus]. PMID- 4322113 TI - [Stages of sleep in the horse (Equus caballus)]. PMID- 4322114 TI - Enzymic changes of plasma membranes isolated from mouse liver during experimental viral hepatitis. PMID- 4322115 TI - [Experimental studies on the mechanism of ACTH secretion]. PMID- 4322116 TI - [Relationship between aggressiveness and the brain cholinesterase activity in mice--effects of chronic administration of ACTH]. PMID- 4322117 TI - [Ethanol induced hypoglycemia]. PMID- 4322118 TI - A release of renin from dog kidney cortex slices. PMID- 4322119 TI - Depressor mechanism of synthetic ACTH (50022). PMID- 4322120 TI - [Multiple myoblastoma and polyps of the bladder]. PMID- 4322121 TI - Familial dysautonomia. A report of genetic and clinical studies, with a review of the literature. PMID- 4322122 TI - Domiciliary psychiatric nursing observed. 2. PMID- 4322123 TI - [Evaluation of selective gastrointestinal arteriography in the diagnosis of benign pancreatic tumors]. PMID- 4322124 TI - [Steroid gas-chromatogram changes under the influence of ACTH]. PMID- 4322125 TI - Lesch-Nyhan syndrome: altered kinetic properties of mutant enzyme. AB - Hypoxanthine-guanine phosphoribosyltransferase is virtually inactive in erythrocytes from patients with the classical Lesch-Nyhan syndrome. In one such patient, activity of this enzyme ranged from 8 to 34 percent of normal in erythrocytes when assayed with a very high concentration of magnesium 5 phosphoribosyl-1-pyrophosphate. In addition, the mutant enzyme exhibited sigmoidal kinetics with this substrate as well as an increased Michaelis constant for both guanine and hypoxanthine. These findings provide the first evidence for genetic heterogeneity within the group of patients with the Lesch-Nyhan syndrome. PMID- 4322126 TI - [Pulmonary fibrosis in 3 workers in the same factory exposed to cobalt and tungsten carbide dust. Pulmonary disorders in the hard metal industry. Apropos of an occupational survey]. PMID- 4322127 TI - [Favorable electroencephalographic course in a case of hepatic coma due to viral hepatitis]. PMID- 4322128 TI - [Polyradiculoneuritis following an insect bite]. PMID- 4322129 TI - Joly JP: [Obesity and fast therapy. Immediate and long-term reducing]. PMID- 4322130 TI - [Changes in the gluocse tolerance test during reducing therapy]. PMID- 4322131 TI - [Electromyography in diabetes mellitus with and without neurologic or arteritic complications in lower limbs]. PMID- 4322132 TI - [Treatment of myeloma]. PMID- 4322133 TI - [Surgically treated case of hepatoma in the neonatal period]. PMID- 4322135 TI - Interactions of the echinoderm toxin holothurin A and its desulfated derivative with the cat superior cervical ganglion preparation. PMID- 4322134 TI - Phenobarbital and dexamethasone inhibition of the adrenocortical response of rats to toxic chemicals and other stresses. PMID- 4322136 TI - The effect of ultra-violet light on the toxicity and the enzymatic and antigenic activities of snake venom. PMID- 4322137 TI - Function of phospholipids in axons: depletion of membrane phosphorus by treatment with phospholipase C. PMID- 4322138 TI - [Latent adenovirus infection of the tonsils]. PMID- 4322139 TI - Chemical studies of cortical diaphyseal bone during vitamin D deficiency in the rat. PMID- 4322140 TI - Focal dermal hypoplasia syndrome. PMID- 4322141 TI - Rheumatoid neuropathy. Clinical and electrophysiological features. PMID- 4322142 TI - [Regulation and functional evaluation of the adrenal-pituitary-hypothalamus axis]. PMID- 4322143 TI - [General incidence, geographical distribution and etiology of cirrhoses in Ivory Coast (60 case repots). Comparative study with primary liver cancer]. PMID- 4322144 TI - Cytomegalovirus infections in pregnancy and the newborn. PMID- 4322147 TI - [Studies on the representation and the mechanism of the physiological phenomena with electrochemical systems]. PMID- 4322145 TI - Endocrine approach in the management of dysfunctional uterine bleeding. PMID- 4322148 TI - Adrenal insufficiency following bilateral adrenal venography. PMID- 4322149 TI - Preparation of 3H-phosphatidylmyoinositol with Kloeckera brevis. PMID- 4322150 TI - [On pituitary function in normal subjects treated with an anabolic steroid]. PMID- 4322151 TI - Crossroads of continuing education. PMID- 4322152 TI - In search ofaa degree--how to begin. PMID- 4322153 TI - Is graduate education for you? PMID- 4322154 TI - [Post-hospital nursing treatment and the community]. PMID- 4322155 TI - [Developmental anomalies in children with a ring chromosome in group E]. PMID- 4322156 TI - [Tumors of the glomus jugulare]. PMID- 4322157 TI - RNA-dependent DNA polymerase activity in five RNA viruses: divalent cation requirements. AB - The RNA-dependent DNA polymerase(s) in murine leukemia, murine mammary tumor, and avian myeloblastosis viruses require maganese for optimal activity. The transcription of added synthetic polyribonucleotides is greatly enhanced when manganese is used in place of magnesium. A soluble RNA-dependent DNA polymerase activity has been released from murine leukemia particles in the presence of manganese and high detergent concentrations. Two RNA viruses, visna virus of sheep and a primate syncytial virus, not known to have tumor-producing ability, also contain the polymerase. PMID- 4322158 TI - Cyclic adenosine monophosphate and norepinephrine: effects on transmembrane properties of cerebellar Purkinje cells. AB - Electrical properties of Purkinje cells were recorded by intracellular microelectrode during extracellular electrophoretic application of gamma aminobutyrate, norepinephrine, cyclic adenosine monophosphate, and dibutyryl cyclic adenosine monophosphate. All these substances hyperpolarized Purkinje cells. Transmembrane resistance decreased during gamma aminobutyrate hyperpolarization. In contrast, norepinephrine and the cyclic nucleotides generally elevated resistance. These results show that cyclic nucleotides mimic the unique effects of norepinephrine on the bioelectric properties of neuronal membranes. PMID- 4322160 TI - Studies of the early events of the replicative cycle of three variants of Mengo encephalomyelitis virus in mouse fibroblast cells. PMID- 4322159 TI - [Age and the endocrine system]. PMID- 4322161 TI - [Enzymatic studies of avian infectious bronchitis. Behavior of some enzymes (GOT, GPT, aldolase, LDH, FAc, FAl, LAP and SDH) in the amino-allantoid fluids of normal and infected embryonated eggs]. PMID- 4322162 TI - Pseudomonas bacteremia in patients with malignant diseases. PMID- 4322163 TI - The pancreas anthe first hormones. PMID- 4322164 TI - Hematologic alterations produced by nitrous oxide. PMID- 4322165 TI - Peripheral nerve abnormalities in the Riley-Day syndrome. Findings in a sural nerve biopsy. PMID- 4322166 TI - Inositol phosphate phosphatases of microbiological origin. Inositol phosphate intermediates in the dephosphorylation of the hexaphosphates of myo-inositol, scyllo-inositol, and D-chiro-inositol by a bacterial (Pseudomonas sp.) phytase. PMID- 4322167 TI - Glycogen, glycogen-metabolizing enzymes, and acid and alkaline phosphatases in the endometrium of the ewe during early pregnancy. PMID- 4322168 TI - [The extra-adrenal action of pituitary adrenocorticotropic hormone on skeletal muscle]. PMID- 4322169 TI - [Corticotropic cells of the hypophysis of the triton (Triturus marmoratus Latr.). Demonstration, by immunofluorescence, of a secretion related to the corticotropic hormone (beta-(1-24) corticotropin)]. PMID- 4322170 TI - Cystosarcoma phylloides (cellular intracanalicular fibroadenoma): clinical pathological relationships. PMID- 4322171 TI - Colitis cystica profunda: a rare lesion of the colon. PMID- 4322172 TI - Neuropathy from old retained freign bodies (glass) in the forearm: report of a case. PMID- 4322173 TI - Treatment of central polydactyly. PMID- 4322174 TI - Changes in heart and skeletal muscle cytochrome oxidase activity during anaerobiosis in the freshwater turtle Pseudemys scripta elegans. PMID- 4322175 TI - [Therapy of the root compression syndrome]. PMID- 4322176 TI - Stimulation of mitotic activity in rat bone marrow and thymus by exogenous adenosine 3'5'-monophosphate (cyclic AMP). PMID- 4322177 TI - Competitive interaction of adenosine 3',5'-monophosphate on gene activation by ecdysterone. PMID- 4322178 TI - The influence of normal cells on the proliferation of tumour cells in culture. PMID- 4322180 TI - [Analysis of the dynamics of euronal function by recording its impulse activity]. PMID- 4322179 TI - [Biochemical changes in the tissues of white rats following systematic muscular activity]. PMID- 4322181 TI - [The dynamics of the background electrical activity of the dorsal and ventral regions of the cat hippocampus]. PMID- 4322182 TI - [Conduction pathways of the cat caudal mesenteric sympathetic ganglion]. PMID- 4322183 TI - Diagnostic procedures in hypopituitary dwarfism. II. Evaluation of ACTH deficiency: metopirone test, the daily oscillation of plasma cortisol and its response to exogenous ACTH, lysin-vasopressin, insulin-induced hypoglycemia and general anesthesia. PMID- 4322184 TI - [Cytomegaly--an often occurring but seldom recognized infection]. PMID- 4322185 TI - [Aminophenols as antidote at hrocyanic acid poisoning]. PMID- 4322186 TI - Unilateral maxillary odontodysplasia. PMID- 4322187 TI - Prognostic significance of tumor doubling time in evaluating operability in pulmonary metastatic disease. PMID- 4322190 TI - [Wilms' tumor]. PMID- 4322189 TI - Contraction times and fiber types in neurogenic paresis. PMID- 4322191 TI - [Clinical experience with a peripheral nerve stimulator in anesthesia]. PMID- 4322188 TI - Histochemical studies on enzyme activities in gastric mucosa cells with special reference to dehydrogenase reactions. I. Studies on distribution of dehydrogenase activity in the normal human gastric mucosa. PMID- 4322192 TI - Comparison of the mortality profiles of Archaic, Middle Woodland, and Middle Mississippian skeletal populations. PMID- 4322194 TI - [Isolation and characterization of rapidly labelled RNA from Euglena gracilis by means of analytical and preparative electrophoresis in polyacrylamide gels]. PMID- 4322197 TI - The catabolic action of glucagon in rat liver. The influence of age, nutritional state and adrenal function on the effect of glucagon on lysosomal N-acetyl-beta, D-glucosaminidase. PMID- 4322198 TI - Neutral protease activity associated with the rat liver peroxisomal fraction. PMID- 4322196 TI - Rate of gluconeogenesis and levels of gluconeogenic enzymes in liver and kidney of diabetic and normal Chinese hamsters. PMID- 4322199 TI - Threonine metabolism in a strain of Bacillus subtilis: enzymes acting on methylglyoxal. PMID- 4322200 TI - One-carbon metabolism and pyridoxal 5'-phosphate biosynthesis. PMID- 4322201 TI - EPR relaxation of slowly moving flavin radicals: "anomalous" saturation. PMID- 4322202 TI - [On the production of SV40 in heterokaryons caused by fusion of sensitive cells with transformed cell exposed to UV irradiation]. PMID- 4322203 TI - [New spectrophotometric method for determination of adenosine cyclic phosphodiesterase activity]. PMID- 4322205 TI - Diagnosis of obstructive jaundice. AB - The diagnosis of obstructive jaundice remains difficult yet vital, since operative decompression may relieve extrahepatic blockage, but operation can only harm patients with intrahepatic block or parenchymal cell inflammation or necrosis. Three new diagnostic methods (liver scanning, angiography, and transjugular transhepatic cholangiography) are reviewed, as is bilirubin metabolism, so important in the diagnosis of jaundice. Three clinical problems are discussed: extrahepatic obstruction due to cancer of the pancreas, biliary atresia causing jaundice in the newborn, and the diffuse ductal obstruction known as sclerosing cholangitis.An accurate diagnosis can usually be made with standard diagnostic techniques, such as history, physical examination and biochemical tests, and, when appropriate, gastrointestinal x-ray studies, cholecystography and cholangiography, liver biopsy, observation of the patient's course, and the three new radiological approaches mentioned above. Extrahepatic obstructive jaundice is an indication for surgical treatment, except perhaps in cases of sclerosing cholangitis. PMID- 4322206 TI - [A colorimetric micromethod for the enzymatic assay of ethanol in blood]. PMID- 4322195 TI - Corynebacterium diphtheriae and its relatives. PMID- 4322204 TI - The rhinoviruses of man. AB - Rhinoviruses, prominent agents of the common cold syndrome in man, are small ribonucleic acid (rna) viruses resembling enteroviruses in their physicochemical properties except for high density and lability to acid pH. Rhinoviruses are propagated in human and monkey cells. Highest titers of virus are obtained in HeLa cell cultures. Rhinoviruses produce characteristic cytopathic effect in diploid fibroblasts. A plaque assay in HeLa cells is useful for their titration. The rhinovirus group includes many serotypes. Although rhinoviruses cause predominantly upper respiratory tract symptoms, they may on occasion infect the lower respiratory tract. Volunteers with specific antibody, when challenged with homotypic rhinovirus, are protected against the common cold. PMID- 4322207 TI - [Langerhans' cell tumor]. PMID- 4322208 TI - Benign pleomorphic adenoma of the cheek: report of a case. PMID- 4322209 TI - Reaction of formaldehyde and of methanol with xanthine oxidase. PMID- 4322210 TI - [Purification and crystallization of NAD glycohydrolase of C streptococci]. PMID- 4322211 TI - [The percutaneous hepatography]. PMID- 4322212 TI - [Two cases of metastatic trophoblastic disease]. PMID- 4322213 TI - Head and neck cancer. Oral cavity: primary lesion. PMID- 4322214 TI - Clinical characteristics of early oral cancer. PMID- 4322215 TI - [Characteristics of cultivated Burkitt's lymphoma cells, with special reference to relationship with proliferation of cells and EB virus]. PMID- 4322216 TI - [Effect of conjugated estrogens on the vaginal epithelium of postmenopausal women]. PMID- 4322217 TI - Survey of the genus Penicillium for tremorgenic toxin production. PMID- 4322218 TI - Incorporation of 32P-orthophosphate into phospholipids by a toxigenic and a nontoxigenic strain of Aspergillus flavus. PMID- 4322219 TI - The role of calcium in the release of neurotransmitter substances and hormones. PMID- 4322221 TI - An unusual artefact. PMID- 4322220 TI - Aging, brain damage, and psychomotor slowing. PMID- 4322222 TI - The lag period after vitamin D administration. PMID- 4322223 TI - A sensitive assay of 18-hydroxydesoxycorticosterone and aldosterone by gas chromatography with electron capture detection. PMID- 4322224 TI - Immunity to murine sarcoma virus (MSV)-induced tumors demonstrated by "in vivo" elimination of 51-chromium labeled tumor cells. PMID- 4322225 TI - Desulfurase activity and chromosome analysis of cultured rat hepatoma cells. PMID- 4322226 TI - [Meningeal hemorrhage in intracranial tumors. Significance of "pseudoaneurysmal forms"]. PMID- 4322227 TI - [Clinical and histological aspects of cardiac metastasis. A propos of 2,258 autopsies]. PMID- 4322228 TI - [Viral particles in the kidney in Balkan endemic nephropathy]. PMID- 4322229 TI - [Diet therapy of kidney calculi]. PMID- 4322230 TI - [Effect of antitubercular preparations on the activity of serum enzymes and the level of 5-oxyindoleacetic acid in the urine in patients with cutaneous tuberculosis]. PMID- 4322231 TI - [Cylindroma of the scalp]. PMID- 4322232 TI - [Treatment of patients with intracerebral spread of juvenile nasopharyngeal angiofibroma]. PMID- 4322233 TI - [Tumors of receptor tissues of otorhinolaryngological organs]. PMID- 4322234 TI - Hormonal influence on the differentiation of nerve cells of sympathetic and parasympathetic nervous system. PMID- 4322235 TI - [Comparative histochemical studies on the secretion of the orbital glands of some mammals and the human oil gland]. PMID- 4322236 TI - Histochemical evidence for the role of macromolecular structural stability in the pathogenesis of diseases. PMID- 4322237 TI - Microscopic and enzyme histochemical studies on the liver and kidney of rats treated with fulvine, the toxic alkaloidal constituent of Crotolaria fulva. PMID- 4322238 TI - [The pathogenesis of INH-neuropathy. I. Fine structural similarities and differences to wallerian degeneration]. PMID- 4322239 TI - Infantile neuroaxonal dystrophy: cortical axonic and presynaptic changes. PMID- 4322240 TI - Statistical signs of synaptic interaction in neurons. AB - The influence of basic open-loop synaptic connections on the firing of simultaneously recorded neurons has been investigated with auto- and cross correlation histograms, using experimental records and computer simulations. The basic connections examined were direct synaptic excitation, direct synaptic inhibition, and shared synaptic input. Each type of synaptic connection produces certain characteristic features in the cross-correlogram depending on the properties of the synapse and statistical features in the firing pattern of each neuron. Thus, empirically derived cross-correlation measures can be interpreted in terms of the underlying physiological mechanisms. Their potential uses and limitations in the detection and identification of synaptic connections between neurons whose extracellularly recorded spike trains are available are discussed. PMID- 4322241 TI - A mathematical study of nerve fiber interaction. AB - This paper presents a quantitative description of the electric field interaction between two adjacent unmyelinated nerve fibers (one active, the other inactive) for the infinite medium and nerve trunk geometries, and considers their dependence on various electrical and geometrical parameters. Based on the use of synthetic giant axon data, the conclusion of this study is that the cross sectional area of the nerve trunk and the specific resistivity of the interstitial medium are of particular importance to the degree of fiber interaction. Other factors such as separation distance between fibers, axoplasmic resistivity, membrane resistance, and capacitance of the inactive fiber, are also investigated and found to be of secondary importance. PMID- 4322242 TI - PGO waves as unitary events. PMID- 4322243 TI - Some properties of cyclic 3',5'-nucleotide phosphodiesterase of mouse brain: effects of imidazole-4-acetic acid, chlorpromazine, cyclic 3',5'-GMP, and other substances. PMID- 4322244 TI - [Changes in the carbohydrate composition of fibrinogen in cases of acquired dysfibrinogenemia]. PMID- 4322245 TI - Actions of tetraphenylboron on neuromuscular transmission in the biventer cervicis muscle of the chick. PMID- 4322246 TI - [Familial recurrent polytopic neuropathy]. PMID- 4322247 TI - [Changes in placental enzyme patterns during pregnancy]. PMID- 4322248 TI - [Cytomegaly]. PMID- 4322249 TI - Synthesis of alpha-D-glucose 1,6-diphosphate, alpha-D-mannose 1,6-diphosphate, alpha-D-ribose 1,5 diphosphate, and N-acetyl-alpha-D-glucosamine 1,6-diphosphate. PMID- 4322251 TI - Matching of excitatory and inhibitory inputs to crustacean muscle fibers. PMID- 4322250 TI - Cyclic nucleotide-dependent protein kinases. 8. An assay method for the measurement of adenosine 3',5'-monophosphate in various tissues and a study of agents influencing its level in adipose cells. PMID- 4322252 TI - Difference in effects of end-plate potentials between procaine and lidocaine as revealed by voltage-clamp experiments. PMID- 4322253 TI - Ionic mechanisms of excitatory, inhibitory, and dual synaptic actions mediated by an identified interneuron in abdominal ganglion of Aplysia. PMID- 4322254 TI - [Prevention of serious accidents in iodate contrastography in radiology]. PMID- 4322255 TI - [Cerebral gangliosides: structure, function and anatomopathological changes]. PMID- 4322256 TI - [Linkage between membrane stimulation and cell function]. PMID- 4322257 TI - Specificity of the DNA product of the C-type virus RNA-dependent DNA polymerase. AB - The specificity of the DNA product of the RNA-dependent DNA polymerase found in C type virions was analyzed by reciprocal hybridization with RNA from viruses of mouse, hamster, cat, and viper. These tests revealed a clear species specificity for the DNA product with no detectable interspecies hybridization. PMID- 4322258 TI - Epinephrine-induced vacuole formation in parotid gland cells and its independence of the secretory process. AB - Catecholamines cause rapid release of K(+) and formation of vacuoles in acinar gland cells. A high K(+) concentration in the medium bathing parotid gland slices prevents vacuole formation by epinephrine and facilitates the secretion of most of the exportable amylase. N(6)-monobutyryl 3':5'-cyclic AMP does not cause K(+) release and vacuole formation although it efficiently induces amylase secretion. It is suggested that the secretory process is independent of vacuole formation. PMID- 4322259 TI - Primary reactions of photosynthesis: photoreduction of a bound chloroplast ferredoxin at low temperature as detected by EPR spectroscopy. AB - An electron paramagnetic resonance signal was observed at 25 degrees K in whole spinach chloroplasts after illumination at 77 degrees K. The light-induced epr spectrum had g-values (g(x) = 1.86, g(y) = 1.94, g(z) = 2.05) and a temperature dependence that were characteristic of the reduced state of a plant-type ferredoxin. The light-induced epr spectrum was also observed in broken spinach chloroplasts from which soluble ferredoxin was removed. Chemical analyses showed that both whole and broken spinach chloroplasts contained amounts of nonheme iron and "acid-labile sulfide" consistent with the presence of a bound iron-sulfur protein, at a level of about one molecule per 75 chlorophyll molecules. These results support the conclusion that chloroplasts contain a bound ferredoxin that may serve as a primary low-potential electron acceptor in photosynthesis. PMID- 4322260 TI - A rapidly acting metabolite of vitamin D3. AB - A vitamin D(3) metabolite in intestine more polar than 25-hydroxy-vitamin D(3)(25 OH D(3)) has been detected by countercurrent distribution. The intestinal metabolite is found also after administration of labeled hydroxy D(3), indicating that it arises from vitamin D(3) via the intermediate 25-hydroxy derivative. The more polar metabolite is localized in the nuclear-chromatin fraction and appears in the gut before the physiological response to vitamin D(3).3.5 mug of the intestinal metabolite was isolated from 1250 chickens; the resulting purified material proved to be a potent mediator of calcium absorption. On a weight basis, it was at least 5 times as effective as vitamin D(3), and acted 3 times faster than either hydroxy D(3) or D(3) in stimulating intestinal calcium transport in the rachitic chick. It is proposed that this as yet uncharacterized steroid represents the active form of vitamin D(3) in the intestine. PMID- 4322261 TI - An adenosine 3':5'-cyclic monophosphate-binding protein that acts on the transcription process. AB - An assay system for the in vitro transcription of the lac operon is described. A protein factor (CAP) and cyclic AMP, which are essential for the lac expression in vivo, also stimulate lac transcription in vitro. PMID- 4322262 TI - pH as a determinant of cellular growth and contact inhibition. AB - 1) Both the growth rate and the maximum population density of several normal, virus-transformed, and cancer cells were markedly pH-dependent; the optimum varied from pH 6.9 to 7.8. At the optimum pH, some diploid human cells attained population densities comparable to those of cancer or virus-transformed cells. Contact inhibition of growth is facilitated by repeated fluctuations of pH in nonphysiological ranges, and may not be an intrinsic and necessary attribute of diploid cells in culture. 2) At pH 8.3, at which there was little or no cellular multiplication, the protein content per cell increased 2- to 5-fold over a period of 10-16 days, and was slowly reversed to normal concentrations on restoration of pH to the optimal range. 3) Uridine uptake by contact-inhibited human cell cultures was stimulated by refeeding with salt solution, and to the same extent as by complete (serum-supplemented) growth medium; that immediate increase did not involve the reinitiation of cellular growth and multiplication. Contact inhibition was, however, reversed in 2-4 days by an appropriate increase in the serum concentration of the medium. PMID- 4322263 TI - Cyclic membrane changes in animal cells: transformed cells permanently display a surface architecture detected in normal cells only during mitosis. AB - A membrane site exposed only during mitosis in normal 3T3 cells, but exposed in all polyomavirus transformed 3T3 (Py3T3) cells, has been detected The site was identified by the specific binding of a wheat-germ agglutinin conjugated with fluorescein isothiocyanate. The receptor site has been studied previously. It binds wheat-germ agglutinin, causing the selective agglutination of Py3T3 cells, but not normal 3T3 cells. A short treatment with low concentrations of trypsin exposes cryptic sites in 3T3 cell membranes; this permits agglutination of these cells. The experiments reported here indicate that these sites normally are exposed during a brief period of the cell cycle for 3T3 cells. Specific hapten inhibitors of agglutination also inhibit the binding of the conjugated agglutinin and prevent fluorescence. PMID- 4322264 TI - A series of hybrid cells containing different ratios of parental chromosomes formed by two steps of artificial fusion. AB - Double hybridization of Ehrlich ascites tumor cells (ETC) and L cells was performed. In the first step, a hybrid (LE) of ETC and L(AG) (a mutant of L cells, resistant to 10 mug/ml of 8-azaguanine) and a hybrid (LL) of L(AG) and L(BrdU) (a mutant of L cells, resistant to 100 mug/ml of 5-bromodeoxyuridine) were prepared by the use of artificial fusion by UV-irradiated HVJ (Sendai virus). In the second step the LE hybrid and ETC, or the LL hybrid and ETC, were fused again by UV-HVJ. The hybrids (LEE and LLE) were segregated during culture. Thus, the series of hybrids L, LLE, LE, LEE, and ETC was obtained. The morphological feature and karyological characters of these hybrids and the distribution of antigens corresponding to each parent on their cell surfaces supported the above identification of the series of hybrids obtained by double hybridization. All three hybrids acquired new characters, such as the ability to form large colonies in soft agar and large tumors on the chorioallantoic membrane of chicken eggs, unlike either parent. The tumor-forming capacity of the series was ETC > LEE > LE > LLE; L cells formed no tumor in mouse abdomen under the test conditions. PMID- 4322265 TI - Synthesis of a biologically active N-terminal tetratriacontapeptide of parathyroid hormone. AB - Determination of the amino acid sequence of bovine parathyroid hormone has led to the synthesis of a tetratriacontapeptide corresponding to the amino-terminal 1-34 residues of the native molecule. The specific biological effects of this synthetic peptide on bone and kidney are qualitatively identical to those of the native hormone in classical bioassays in vivo and in several systems in vitro. Potency of the synthetic peptide equals or exceeds that of a biologically active fragment of comparable size isolated from the native hormone; the synthetic and natural peptides show complete immunological cross-reactivity. Thus, essential requirements for the physiological actions of the peptide on both skeletal and renal tissue are contained within the 34 amino-terminal amino acids. The potency of the synthetic peptide, relative to that of the native (84-amino acid) polypeptide, is greater in vitro than in vivo; this suggests that the carboxyl terminal two-thirds of the native hormone may protect the circulating polypeptide from rapid metabolic degradation. PMID- 4322266 TI - Proton magnetic resonance studies of the ferredoxins from spinach and parsley. AB - Contact-shifted resonances have been detected in the pmr spectra of both oxidized and reduced forms of spinach and parsley ferredoxins. These resonances are assigned to the beta-CH(2) protons of four cysteine residues that are thought to bind the iron-sulfur redox center to the polypeptide chain. Temperature dependences of contact shifts reveal that the two iron atoms are antiferromagnetically coupled in both redox forms of each of these proteins. Thermal population of magnetic states gives rise to the contact shifts observed in the formally diamagnetic oxidized forms of these ferredoxins and accounts for the failure of contact shifts in the reduced forms exhibit to a Curie Law temperature dependence. It appears that the unpaired electron of reduced spinach and parsley ferredoxin is unequally distributed over the two iron centers. Valence states for the iron pairs of high-spin Fe(+3)-Fe(+3) and Fe(+2)-Fe(+3) for the oxidized and reduced forms, respectively, are compatible with the nmr results. PMID- 4322267 TI - Evidence for a vitamin D 3-induced calcium-binding protein in new world primates. PMID- 4322268 TI - Differential effect of 7,12-dimethylbenz(a)anthracene on infectivity of herpes simplex virus type 2. PMID- 4322269 TI - Migratory inhibition of sensitized peritoneal macrophages by tumor-specific transplantation antigen in Morris hepatoma 5123. PMID- 4322270 TI - [Therapeutic prospects of a technic for controlling mental processes during sleep]. PMID- 4322271 TI - [Considerations and interpretative hypotheses on the state of consciousness in the course of mental imagery (with reference to Bash's concept of consciousness)]. PMID- 4322272 TI - The action of antibiotics on carotenoid production by strains of Sarcina lutea. PMID- 4322273 TI - [Formation and release of nucleases by Proteus mirabilis in dependence on the growth phases]. PMID- 4322274 TI - Vesicular stomatitis and related viruses. PMID- 4322275 TI - Immunofluorescent localization of equine infectious anemia virus in tissue. PMID- 4322276 TI - Immunotherapy of cancer in man. VII. Studies of patients with cancer of the alimentary tract. PMID- 4322277 TI - Carcinoid-islet cell tumors of the duodenum. Report of twenty-one cases. PMID- 4322278 TI - Micro indirect hemagglutination test for Cytomegalovirus. AB - In an effort to obtain the flexibility and ease of performance of a rapid, serological test for detection of cytomegalovirus antibody, the indirect hemagglutination (IHA) technique was investigated by using a microserological system. Antigens were prepared from tissue cultures of infected human fibroblasts. The specificity of the cytomegalovirus antibody response detected by the IHA test correlated well with the standard neutralization test. The IHA method was more sensitive than the complement fixation test in detecting antibody in congenitally infected newborns. There appeared to be some heterologous antibody response with Herpesvirus hominis or varicella virus infections. The IHA test pattern was found to be very stable with excellent persistence of agglutination. PMID- 4322279 TI - Improved chemically defined basal medium (CMRL-1969) for primary monkey kidney and human diploid cells. AB - An improved tissue culture basal medium, CMRL-1969, supplemented with serum, has been evaluated by measuring the growth responses of primary cultures of trypsin dispersed monkey kidney cells (PMKC) and of an established culture of a human diploid cell strain (HDCS). Medium H597, an early modification of medium 199 which has been used successfully in the preparation of poliomyelitis vaccine for 15 years, was used for comparison. In addition, parallel testing was done with Basal Medium Eagle (BME) widely used for the growth of HDCS. The improvements in basal medium CMRL-1969 are attributed to changes in amino acid concentrations, in vitamin composition, and, in particular, to enhanced buffering capacity. The latter has been achieved by the use of free-base amino acids and by increasing the dibasic sodium phosphate. The new medium has already been used to advantage for the production of polioviruses in PMKC where equivalent titers were obtained from cultures initiated with 70% of the number of cells required with earlier media. The population-doubling time was reduced in this system. Also, with small inocula of HDCS, the time required to obtain maximum cell yield was shorter with CMRL-1969 than with BME. Both media were supplemented with 10% calf serum. Maximum cell yields after repeated subcultivation in the new basal medium were greatly increased and the stability of the strain, as shown by chromosomal analysis, was not affected. Basal medium CMRL-1969 can be prepared easily in liquid or powdered form. PMID- 4322280 TI - Occurrence of a carrier state for Herpesvirus tamarinus in Marmosets. AB - The ecology of herpesviruses in marmosets and other nonhuman primates is important today, for colonies of these animals are being established for biomedical research. This paper presents the first reported isolations of Herpesvirus tamarinus from throat swabs of a healthy white-lipped marmoset carrier (Saguinus nigricollis) during a 2-month period. Infectivity studies with this virus in both white-moustached (S. mystax) and white-lipped marmosets demonstrated that the virus is not lethal to white-moustached marmosets (perhaps a more resistant species) at 1,000 TCID(50). Which environmental conditions trigger the unmasking of herpesviruses in marmosets is not known. Hoever, intermittent H. tamarinus shedding may help explain spontaneous infections in established colonies as well as suggest an additional mechanism for transmission of virus between marmosets under natural conditions. PMID- 4322281 TI - Indirect hemagglutination test for detection of antibodies to Cytomegalovirus. AB - An indirect hemagglutination test has been adapted for use with cytomegalovirus. The test is highly sensitive and reproducible. Both immunoglobulin M and immunoglobulin G antibodies can be detected by this method. The hemagglutination reaction can be inhibited by small amounts of homologous antigen. This principle permits early identification of virus isolated from diagnostic specimens. PMID- 4322282 TI - Lecithin-agar assay for lecithinase antibodies in serum. AB - A technique for assay of lecithinase antibodies in serum was developed in this laboratory by using a lecithin-agar plate diffusion procedure based on a combination of described plate assays. Egg yolk lipoprotein composed primarily of lecithin was used as a substrate for reaction with free or non-neutralized lecithinase C after incubation of known amounts of lecithinase C with various dilutions of control and test sera. It was found that the size of the reaction zone was a function of enzyme concentration and inversely proportional to the antibody concentration. Accuracy and precision of the assay were determined. In addition, lecithinase antibody levels in sera from experimentally inoculated rats and rabbits and sera from randomly selected human patients were studied. PMID- 4322283 TI - Metabolism of (1,2)3H-vitamin D3 and (26,27)3H-25-hydroxyvitamin D3 in rachitic chicks. PMID- 4322284 TI - The metabolism of O-phosphorylethanolamine in animal tissues. II. Metabolic regulation of O-phosphorylethanolamine phospho-lyase in vivo. PMID- 4322285 TI - Biogenesis of mitochondria. XVII. The role of mitochondrial and cytoplasmic ribosomal protein synthesis in the oxygen-induced formation of yeast mitochondrial enzymes. PMID- 4322286 TI - The preparation and assay of sedoheptulose-7-phosphate. PMID- 4322287 TI - Properties of spinach ferredoxin in anaerobic urea solution: a comparison with the native protein. PMID- 4322288 TI - Regulatory sulfhydryl groups and activation by homocystine in liver fructose diphosphatase. PMID- 4322289 TI - A study of formaldehyde dismutation by liver alcohol dehydrogenase with NAD plus analogs. PMID- 4322290 TI - Inhibition of electron and energy transfer in mitochondria by 19-nor ethynyltestosterone acetate. PMID- 4322291 TI - Primary acquired agammaglobulinemia, with granulomas of the skin and internal organs. PMID- 4322292 TI - Linear ichthyosis associated with skeletal abnormalities. PMID- 4322293 TI - Studies on a cytochrome oxidase antibody. II. Inhibition kinetics. PMID- 4322294 TI - Conversion of biomembrane-produced energy into electric form. 3. Chromatophores of Rhodospirillum rubrum. PMID- 4322295 TI - The energy-yielding oxidation of NADH by fumarate in submitochondrial particles of rat tissues. PMID- 4322296 TI - The role of the alpha-glycerophosphate shuttle in the reoxidation of cytosolic NADH in Ehrlich ascites tumour cells. PMID- 4322297 TI - Studies on a cytochrome oxidase antibody. I. Immunochemistry. PMID- 4322298 TI - Preparation and characterization of golgi membranes from rat liver. PMID- 4322299 TI - The interaction of small molecules with spin-labelled erythrocyte membranes. PMID- 4322300 TI - Subcellular distribution of thiamine pyrophosphokinase activity in rat liver and erythrocytes. PMID- 4322301 TI - Sterol structure and ordering effects in spin-labelled phospholipid multibilayer structures. PMID- 4322302 TI - [Nerve injuries of the hand]. PMID- 4322303 TI - [Cyclic adenosine monophosphate]. PMID- 4322304 TI - Steroidogenic effect of stimulators of aldosterone biosynthesis upon separate zones of the rat adrenal cortex. Influence of sodium and potassium deficiency. PMID- 4322305 TI - The effect of tyramine, noradrenaline, and angiotensin on the blood pressure in hypertensive patients with aldosteronism and low plasma renin. PMID- 4322306 TI - A histochemically demonstrable thiaminepyrophosphatase activity in the sinusoidal endothelium of the liver. PMID- 4322307 TI - Studies in lipid histochemistry. 3. Reaction of Schiff's reagent with plasmalogens. PMID- 4322308 TI - [Cancer of the stomach with metastases to the omentum maius treated surgically. 8 year survival]. PMID- 4322309 TI - The rationale of alternate-day corticosteroid therapy. PMID- 4322310 TI - Racial variations in tumour incidence in Uganda. PMID- 4322311 TI - [Various aspects of histochemical and genetic studies of hormone-dependent tumors in man]. PMID- 4322312 TI - [Pathogenicity of Rous sarcoma virus in relation to the Transcaucasian hamster]. PMID- 4322313 TI - [Effect of quartz and quartz-containing dust on the estrus cycle in white rats]. PMID- 4322314 TI - [Testis and the pituitary gland]. PMID- 4322315 TI - Infection and disease in a group of South Indian families. 3. Virological methods and a report of the frequency of enteroviral infection in preschool children. PMID- 4322316 TI - lveolar cell carcinoma presenting as a pneumothorax. PMID- 4322317 TI - The role and maintenance of the tricarboxylic acid cycle in Escherichia coli. PMID- 4322318 TI - Irradiation-induced constrictive pericarditis in intestinal lymphangiectasis. PMID- 4322319 TI - Synthesis of corticotropin peptides. XII. The effect of amino-terminal substitution in the corticotropin 1-18 peptide. PMID- 4322320 TI - Magnetic susceptibility and EPR measurements of catalase and its derivatives. A thermal equilibrium between the high- and low-spin states in the catalase-azide compound. PMID- 4322321 TI - Effect of pH on the optical absorption spectrum and effective number of the Bohr magneton of horse erythrocyte catalase in the range from 77 degrees K to 267 degrees K. PMID- 4322322 TI - Possible structure of the thymidylic acid-rich fragments obtained from bacteriophage fl DNA. PMID- 4322323 TI - Transaminase of branched chain amino acids. VII. Comparative studies on isozymes of ascites hepatoma and various normal tissues of rat. PMID- 4322325 TI - [Rhinovirus infections]. PMID- 4322324 TI - Viruses associated with acute respiratory infections in Royal Air Force personnel. AB - All respiratory illnesses which were reported to the medical officers between September 1966 and December 1967 on a Royal Air Force station of 350 men were studied virologically.THREE PERIODS OF INCREASED RESPIRATORY INFECTIONS WERE OBSERVED: two occurred in the autumn, one in each year, and the third in the winter during January and February. The autumnal outbreaks were associated mainly with rhinovirus infections, and high isolation rates (82.1, 65.9%) were achieved at these times. Few of the illnesses during the winter outbreak could be diagnosed in the laboratory, and no evidence was found of infection with ;coronaviruses'.Despite the entrance of 30 fresh recruits direct from civilian life every 5 weeks, the respiratory infections encountered on the station were very similar to those in the local population and were not predominantly infections with adenoviruses, Coevirus, and Mycoplasma pneumoniae, as previously reported from larger military recruit centres. PMID- 4322326 TI - [Histochemical study of adrenal gland and muscles in pancreatectomized dogs]. PMID- 4322327 TI - Glioblastoma multiforme. PMID- 4322328 TI - Increase in plasma progesterone caused by undernutrition during early pregnancy in the ewe. PMID- 4322330 TI - Wilms' tumour. PMID- 4322329 TI - Stimulation of auxin-induced cell expansion in plant tissue by cyclic 3',5' adenosine monophosphate. PMID- 4322331 TI - [Tumor of the carotid glomus (chemodectoma)]. PMID- 4322333 TI - [Study of neutralizing antibodies in some enterovirus infections]. PMID- 4322332 TI - Large-volume myelography. An aid in the evaluation of curvatures of the spine. PMID- 4322335 TI - [Studies on the behavior of energy metabolism in various strata of the myocardium: enzyme distribution pattern of the inner and outer strata of the left ventricular myocardium]. PMID- 4322334 TI - A histological and histochemical study of the development of the sternum in thalidomide-treated rats. PMID- 4322336 TI - [Peptide metabolism in liver insufficiency]. PMID- 4322337 TI - [Classification of animal viruses according to functional viewpoints, especially of cytocide virus species]. PMID- 4322338 TI - [Data on virus induced tumor genesis--DNA tumor viruses (polyoma SV 30)]. PMID- 4322339 TI - [Tasks of virus diagnostics in internal medicine]. PMID- 4322340 TI - [Combined immunization against influenza and other viral respiratory infections]. PMID- 4322341 TI - A comparison of the diagnostic value of adenoviral complement-fixing antigens prepared from various immunotypes. PMID- 4322342 TI - Renin, renin substrate, and angiotensin I-converting enzyme in the lymph of rats. PMID- 4322343 TI - Direct myocardial effects of angiotensin II. PMID- 4322344 TI - Insulin regulation of hepatic glycogen metabolism in the dog. PMID- 4322345 TI - Role of bronchial brushing in the evaluation of peripheral lung lesions. PMID- 4322346 TI - D-Mannitol utilization in Salmonella typhimurium. AB - A biochemical and genetic analysis of d-mannitol metabolism in Salmonella typhimurium indicates that d-mannitol is phosphorylated by the phosphoenolpyruvate-dependent phosphotransferase system. d-Mannitol-1-phosphate is converted to d-fructose-6-phosphate by mannitol-1-phosphate dehydrogenase. Two classes of mannitol mutants are described. Both map at about 115 min on the Salmonella chromosome. Mutants missing mannitol-1-phosphate dehydrogenase activity are mannitol sensitive; i.e., either growth is inhibited or the cells are lysed in the presence of mannitol. In a strain missing adenyl cyclase activity, the mannitol genes require exogenous cyclic adenosine-3',5' monophosphate for expression. PMID- 4322347 TI - Catabolite repression in the D-serine deaminase system of Escherichia coli K-12. AB - The induced synthesis of d-serine deaminase in Escherichia coli is subject to three catabolic effects: inhibition on inducer uptake, transient repression, and catabolite repression. Inhibition on d-serine uptake is not significant at the d serine concentration normally used for induction. Transient repression and catabolite repression of d-serine deaminase synthesis are abolished by mutations in dsdCy, which appears to be an operator locus. The decline in the rate of constitutive synthesis observed in dsdCx mutants growing with glycerol as carbon source at temperatures above 37 C is due to catabolite repression. The low level of constitutivity at 37 C and the partial cis dominance of dsdCx mutants are not artifacts of catabolite repression. It is suggested that a product of one of the genes of the dsd operon may regulate the expression of the operon. PMID- 4322348 TI - Catabolite repression of tryptophanase in Escherichia coli. AB - Catabolite repression of tryptophanase was studied in detail under various conditions in several strains of Escherichia coli and was compared with catabolite repression of beta-glactosidase. Induction of tryptophanase and beta galactosidase in cultures grown with various carbon sources including succinate, glycerol, pyruvate, glucose, gluconate, and arabinose is affected differently by the various carbon sources. The extent of induction does not seem to be related to the growth rate of the culture permitted by the carbon source during the course of the experiment. In cultures grown with glycerol as carbon source, preinduced for beta-galactosidase or tryptophanase and made permeable by ethylenediaminetetraacetic acid (EDTA) treatment, catabolite repression of tryptophanase was not affected markedly by the addition of cAMP (3',5'-cyclic adenosine monophosphate). Catabolite repression by glucose was only partially relieved by the addition of cAMP. In contrast, under the same conditions, cAMP completely relieved catabolite repression of beta-galactosidase by either pyruvate or glucose. Under conditions of limited oxygen, induction of tryptophanase is sensitive to catabolite repression; under the same conditions, beta-galactosidase induction is not sensitive to catabolite repression. Induction of tryptophanase in cells grown with succinate as carbon source is sensitive to catabolite repression by glycerol and pyruvate as well as by glucose. Studies with a glycerol kinaseless mutant indicate that glycerol must be metabolized before it can cause catabolite repression. The EDTA treatment used to make the cells permeable to cAMP was found to affect subsequent growth and induction of either beta-galactosidase or tryptophanase much more adversely in E. coli strain BB than in E. coli strain K-12. Inducation of tryptophanase was reduced by the EDTA treatment significantly more than induction of beta-galactosidase in both strains. Addition of 2.5 x 10(-3)m cAMP appeared partially to reverse the inhibitory effect of the EDTA treatment on enzyme induction but did not restore normal growth. PMID- 4322349 TI - Ultrastructural characteristics of Coccidioides immitis, a morphological variant of Cryptococcus neoformans and Podosypha ravenelii. AB - Electron microscopic examination of Coccidioides immitis revealed dense septum associated bodies, characteristic of Ascomycetes. Similar examinations of a filamentous variant of Cryptococcus neoformans failed to clarify the taxonomic position of this yeast but did not exclude the possibility that this organism is a heterobasidiomycete. Septal pores were not seen in either organism. PMID- 4322350 TI - Bacillus thuringiensis sporulation at suboptimal temperature. AB - Bacillus thuringiensis var. thuringiensis Berliner grown at 14 C on a chemically defined liquid medium slowly produced spores and parasporal inclusions. Sporulation ultimately attained 50 to 100% of that of cultures grown at 30 C. PMID- 4322351 TI - A comparison between Greulich-Pyle and Tanner-Whitehouse assessments of skeletal maturity. PMID- 4322352 TI - [Pasteur Vallery-Radot (1886-1970)]. PMID- 4322353 TI - Combined effect of irradiation and of some hormones on catheptic activity in rat spleen. PMID- 4322354 TI - The effect of ifferent bactericidal systems on B. prtussis and B. parapertussis organisms. PMID- 4322355 TI - Effect of adenosine 3'5'-monophosphate on para-aminohippurate uptake by renal cortical slices. PMID- 4322356 TI - ACTH release from heterotopic pituitary grafts in chicken embryos treated with metyrapone. PMID- 4322357 TI - [Effect of morphocycline and levomycetin on the multiplication of Clostridia]. PMID- 4322358 TI - [Cytochemical analysis of the effect of antineoplastic antibiotic reumycin]. PMID- 4322359 TI - Primary adenocarcinoma of choroid plexus. PMID- 4322360 TI - Neoplasm to neoplasm metastasis. An acidophil adenoma harbouring metastatic carcinoma: a case report. PMID- 4322361 TI - Micropuncture evaluation of local control of arteriolar resistance of kidney and brain. PMID- 4322362 TI - Hemodynamic and therapeutic effects of guancydine in hypertension. PMID- 4322363 TI - [A case of acquired virilization with neurological symptoms]. PMID- 4322364 TI - [Evaluation of adrenal function after unilateral partial adenalectomy]. PMID- 4322365 TI - [The hypoglycemic syndromes. Fundamentals of medical therapy]. PMID- 4322366 TI - [Biological and skeletal age of the fetus]. PMID- 4322367 TI - Effects of xanthine derivatives on lipolysis and on adenosine 3',5'-monophosphate phosphodiesterase activity. PMID- 4322368 TI - Purification and properties of rat heart 5'-nucleotidase. PMID- 4322369 TI - Excitation-contraction coupling in heart. 3. Evidence against the involvement of adenosine cyclic 3',5'-monophosphate in calcium transport by sarcotubular vesicles of canine myocardium. PMID- 4322370 TI - [Puberty and its indices in hand and wrist radiograms in boys from Warsaw schools]. PMID- 4322371 TI - The relationship between functional vasodilatation in adipose tissue and prostaglandin. AB - 1. Earlier it had been found that during fat mobilization there was an increased blood flow in the adipose tissue and the tissue contained a vasodilator substance.2. Extract of an activated fat pad contained 3 to 25 times as much activity as the contralateral resting fat pad.3. The following findings suggest that the vasodilator substance is prostagladin E(2):(a) It caused contractions of the guinea-pig ileum which were not reduced by mepyramine, but were reduced by atropine.(b) It caused a prolonged vasodilator response when injected closearterially to the epigastric fat pad.(c) It was eluted from a silicic acid column by a solvent system which is known to elute prostaglandins of the E series but not those of the F series.(d) Its indices of discrimination were similar to those of prostaglandin E's when assayed on three different pharmacological preparations.(e) On thin-layer chromatography it behaved more like prostaglandin E(2) than E(1).4. Neither prostaglandin E(1) nor prostaglandin E(2) inhibited the release of free fatty acids from the rabbit epigastric fat pad by ACTH(1-24).5. It seems likely that prostaglandin E(2) is responsible for the vasodilatation accompanying fat mobilization from adipose tissue. PMID- 4322372 TI - Possible existence of different types of angiotensin II receptors. PMID- 4322373 TI - Angiotensin auto-potentiation. PMID- 4322374 TI - Blockade of the effects of valyl-5-angiotensinamide II, oxytocin, noradrenaline, 5-hydroxytryptamine and acetylcholine by guancydine. PMID- 4322376 TI - The responses of the isolated perfused spleen of man to sympathetic nerve stimulation, catecholamines and polypeptides. PMID- 4322375 TI - A comparison of the effects of betamethasone and tetracosactrin on hypothalamo pituitary-adrenal activity in the rat. PMID- 4322377 TI - A morphological and biochemical study of subcellular fractions of the guinea pig spinal cord. PMID- 4322378 TI - The effect of ACTH on the synthesis of proteins in spinal motoneurones as studied by autoradiography. PMID- 4322379 TI - Cyclic 3',5'-nucleotide phosphodiesterase in nerve endings of developing rat brain. PMID- 4322381 TI - Prompt stimulation by TSH of thyroid oxidation of thiocyanate. PMID- 4322380 TI - Factors responsible for the carcinoid spectrum. A review. AB - Current knowledge strongly supports the theory that the carcinoid spectrum reflects the clinical signs of production, by a carcinoid tumor or by metastatic lesions, of one or more humoral substances. Serotonin, the kinins, histamine (and perhaps other amines), adrenocorticotropic hormone and additional hormones are manufactured by these tumors. Elevated concentrations of serotonin, the kinins and histamine have been found in patients with the carcinoid syndrome, which includes right-sided valvular heart disease, peripheral vasomotor disturbances, bronchoconstriction, borborygmi and an unusual type of cyanosis. PMID- 4322382 TI - Effects of serotonin on iodide and intermediary metabolism in isolated thyroid cells. PMID- 4322383 TI - Mechanism of inactivation of oxytocin by rat kidney enzymes. PMID- 4322384 TI - Nucleotide specificity of the steroidogenic response of rat adrenal cell suspensions prepared by collagenase digestion. PMID- 4322385 TI - Radioimmunoassay of plasma ACTH in intact rats. PMID- 4322386 TI - Bioassay and radioimmunoassay of plasma ACTH in adrenalectomized rats. PMID- 4322387 TI - Action of cyclic guanosine monophosphate on thyroid weight and protein. PMID- 4322388 TI - The effect of corticotropin on neuromuscular junction--morphological study in rats. PMID- 4322389 TI - [Removal of an angiofibromyxoma of the right ventricle obstructing the exit path]. PMID- 4322390 TI - Periodic hormonogenesis--a new phenomenon. Periodicity in function of a hormone producing tumor in man. PMID- 4322391 TI - Studies of endocrine function in boys with retarded growth, delayed sexual maturation and zinc deficiency. PMID- 4322392 TI - Studies on the deficiency of 21-hydroxylation in patients with congenital adrenal hyperplasia. PMID- 4322393 TI - On the endocrine adaptation to regular muscular activity. PMID- 4322394 TI - Determination of vitamins D by gas-liquid chromatography. I. Differentiation and assay of vitamins D2 and D3. PMID- 4322395 TI - [Effect of hypertension on the renin-aldosterone system, renal circulation, glomerular filtration and electrolyte excretion in patients with chronic circulatory insufficiency]. PMID- 4322396 TI - [Familial occurrence of diffuse interstitial pulmonary fibrosis complicated by alveolar cell carcinoma]. PMID- 4322397 TI - [Cytomegalovirus infection in adults: virological aspects]. PMID- 4322398 TI - [Cytomegalovirus infection in adults]. PMID- 4322399 TI - No evidence of active renin-inhibitors in plasma. The kinetics of the reaction between renin and substrate in non-pre-treated plasma. PMID- 4322400 TI - Abolished sympathetic stimulating effect of angiotensin in rabbits immunized with angiotensin-II. PMID- 4322401 TI - Assay of urinary estrogen by isotope dilution method in abnormal pregnancy. PMID- 4322402 TI - Pituitary-adrenal relationships. PMID- 4322403 TI - Inhibition by toyocamycin of RNA synthesis in mammalian cells and in normal and avian tumor virus-infected chick embryo cells. PMID- 4322404 TI - Evidences for proximal tubular site of action of intravenous ethacrynic acid (Lyovac-Edecrin) obtained during antiotensin infusion in diabetes insipidus. PMID- 4322405 TI - The effect of corticotrophine and cortisone on the content of sialic acids in mucous membrane of rat gastrointestinal tract. PMID- 4322406 TI - [Susceptibility of the serum properdin system to hormones]. PMID- 4322407 TI - [The clinic picture and therapy of carcinoma of the auricle and external auditory canal]. PMID- 4322408 TI - Cytomegalovirus infection--autopsy study. PMID- 4322409 TI - The biphasic effect of nicotinic acid on plasma FFA levels. PMID- 4322410 TI - More about cytomegalovirus infection. PMID- 4322411 TI - Evaluation of renin and angiotensin assays and their clinical application. PMID- 4322412 TI - [Neuroendocrinological study in chlorpromazine-treated rats]. PMID- 4322413 TI - [Radiographic diagnosis of intrasellar and suprasellar space consuming processes in the native roentgenogram]. PMID- 4322414 TI - [Gastric fibroscopy with directed biopsy in 60 patients with gastric cancer]. PMID- 4322416 TI - [Value of histological examination of the liver by puncture-biopsy when laparoscopy shows an apparently little altered liver]. PMID- 4322415 TI - [3 cases of colonic Crohn's disease]. PMID- 4322417 TI - [Survey apropos of 85 unexplained digestive hemorrhages]. PMID- 4322418 TI - [Atypically located hemorrhagic ulcers of the gastric body]. PMID- 4322419 TI - [Indications and results of the Dragstedt and pyloroplasty for bulbar ulcer]. PMID- 4322421 TI - [Good luck letter to patients with an artificial anus]. PMID- 4322420 TI - [Diabetic neuropathy and angiopathy. Anatomo-clinical correlation and pathogenic deductions]. PMID- 4322422 TI - Afferent pathways of stressful stimuli: their dependence on strength and the time elapsed after the onset of stimulation. PMID- 4322424 TI - 24Na uptake and PAH accumulation of renal cortical slices in the presence of angiotensin. PMID- 4322423 TI - Cytochrome oxidase determination using a manganese citrate complex. PMID- 4322425 TI - Relationships between the structure and the adrenal and extra-adrenal effects of ACTH fragments. PMID- 4322426 TI - Corticotrophin release induced by traumatic stress in rats with unilateral spinal cord lesion. PMID- 4322427 TI - The medial thalamus and the opposite effect of corticosteroids and adrenocorticotrophic hormone on avoidance extinction in the rat. PMID- 4322428 TI - Unusual radiation response in various inoperable radioresistant tumors. PMID- 4322429 TI - Ovarian cancer with special regard to radiotherapy. PMID- 4322430 TI - Cystinosis. An ultrastructural and electron-probe study of the kidney with unusual findings. PMID- 4322431 TI - Submicroscopic effects of hormones on articular cartilage of adult mice. PMID- 4322432 TI - Ultrastructure of Entamoeba histolytica from human amebic dysentery. PMID- 4322433 TI - Importance of central vasomotor effects in angiotensin-induced hypertension. AB - Ablation of the areas postrema in 10 dogs caused a highly significant reduction in the pressor response to intravenous infusions of angiotensin yet was without significant effect on the pressor response to intravenous infusions of noradrenaline. The reduction in the pressor response to angiotensin is almost certainly due to abolition of the specific central autonomic effects of the hormone which are dependent on the integrity of the areas postrema. It is suggested that this central effect also contributes to the cardiovascular response to endogenous angiotensin. PMID- 4322434 TI - Success and failure in human virus diseases. II. Common viruses. PMID- 4322435 TI - Physical and chemical studies on ceruloplasmin. IX. The role of galactosyl residues in the clearance of ceruloplasmin from the circulation. PMID- 4322436 TI - Evidence for the induction of iodide transport in bovine thyroid cells treated with thyroid-stimulating hormone or dibutyryl cyclic adenosine 3',5' monophosphate. PMID- 4322437 TI - Studies on the mechanism of action of calciferol. I. Basic parameters of vitamin D-mediated calcium transport. PMID- 4322439 TI - Subcellular distribution of adenosine 3',5'-monophosphate-dependent protein kinase in rat brain. PMID- 4322438 TI - Studies on the mechanism of action of calciferol. II. Effects of the polyene antibiotic, filipin, on vitamin D-mediated calcium transport. PMID- 4322440 TI - Differential effects of glucocorticoids and adenosine 3',5'-monophosphate on hepatic enzyme synthesis. PMID- 4322441 TI - Rabbit liver phosphofructokinase. Comparison of some properties with those of muscle phosphofructokinase. PMID- 4322442 TI - The role of energy metabolism in calcium-evoked secretion from the adrenal medulla. AB - 1. Experiments were carried out on cat adrenal glands perfused with Locke solution to study the effects of inhibition of metabolism on calcium-evoked catecholamine release.2. In the presence of sodium cyanide (CN, 0.2 mM), a low concentration of glucose (1 mM) prevented the gradual decline in the secretory response to sequential exposures to calcium. Furthermore, when the secretory response was almost completely blocked by perfusing with a glucose-deprived solution containing CN, restoration of secretion was correlated with the glucose concentration in the perfusion medium.3. In the presence of CN, 2-deoxyglucose blocked both the protective effect and the restorative effect of glucose. The deoxyglucose inhibition of the glucose-dependent restoration of secretion was antagonized by a higher concentration of glucose.4. Restoration of calcium-evoked secretion was also observed after the washout of CN. The extent of this restoration was not at all related to the glucose concentration and was not affected by various inhibitors of carbohydrate metabolism, including deoxyglucose.5. Analysis of adrenal glands which had been perfused first with a glucose-free solution containing CN and subsequently with the normal medium indicated that no discernible synthesis of catecholamines had taken place during the experimental procedures.6. The data provide further evidence that the action of calcium to trigger medullary secretion requires the presence of metabolic energy and support the hypothesis that an interaction between calcium and high energy nucleotides is a step in the sequence of events leading to the extrusion of catecholamines from the chromaffin cell. PMID- 4322443 TI - The effect of the renin-angiotensin system on mucosal water and sodium transfer in everted sacs of rat jejunum. AB - 1. Mucosal water and sodium transfer were measured in everted sacs of rat jejunum.2. Rats maintained on a high sodium diet did not show consistently reduced mucosal water transfer and aldosterone also failed to stimulate transfer unless the control untreated values were low.3. Adrenalectomy produced little reduction in mucosal water transfer and aldosterone was without effect on water transfer in sacs from adrenalectomized rats.4. Vasopressin had no effect on mucosal transfer.5. Levels of water transfer were not reduced after hypophysectomy nor did aldosterone injection increase transfer.6. Mucosal water transfer in sacs from adrenalectomized-nephrectomized rats was low and was significantly increased by aldosterone injection or by injection of crude kidney extract.7. A significant increased mucosal water and sodium transfer was observed when sacs from adrenalectomized-nephrectomized rats were incubated with angiotensin at a concentration of 10(-10)g/ml.8. It is suggested that the renin angiotensin system may be involved in the maintenance of sodium homoeostasis by a direct action on sodium transporting mechanisms. PMID- 4322444 TI - The control of colon fluid transport by aldosterone and angiotensin. PMID- 4322445 TI - Evidence for a medullary site of action in the cardiovascular response to angiotensin II. PMID- 4322446 TI - [Hypertension and adrenocortical function. I. Studies of patients suffering from high blood pressure on the basis of the adrenocortical function]. PMID- 4322447 TI - [Hypertension and adrenocortical function. II. Adrenocortical function in experimental hypertension]. PMID- 4322448 TI - [Occurrence and significance of myoepithelial cells (myothelia) in tumors]. PMID- 4322450 TI - [Fetal adrenals and the production of estrogens during pregnancy]. PMID- 4322449 TI - [Enzyme histological findings in skeletal muscle of man. 3. The muscular picture in polyneuropathic diseases]. PMID- 4322451 TI - [Probable oncogenic action of the DNA virus in humans]. PMID- 4322452 TI - [Nodular hilar cell proliferation of the ovary in connatal adrenogenital syndrome]. PMID- 4322453 TI - A follow-up study of physical growth following failure to thrive with special reference to a critical period in the first year of life. PMID- 4322454 TI - Abnormal sexual differentiation. PMID- 4322455 TI - Enterotoxigenicity of Staphylococcus aureus cultures isolated from acute cases of bovine mastitis. AB - To determine whether staphylococci causing bovine mastitis are potential causes of human intoxications, 142 cultures identified as etiological agents of acute cases and 18 cultures causing chronic cases of staphylococcal mastitis were obtained from investigators in the United States and Canada, examined microscopically, and tested for carbohydrate utilization, terminal pH, catalase, coagulase, egg yolk hydrolysis, gelatin hydrolysis, cytochrome oxidase, urease production, nitrate reduction, micrococcal nuclease, phage type, and enterotoxin production. Three cultures were not confirmed as Staphylococcus aureus. Of the 157 S. aureus cultures, 23 produced staphylococcal enterotoxins. Although a direct relationship between staphylococcal mastitis and outbreaks of staphylococcal food poisoning was not proved, results indicated that staphylococcal infections of the bovine mammary gland represent a significant reservoir of enterotoxigenic strains of S. aureus. PMID- 4322457 TI - [Antibodies against beta-1-24 corticotropin]. PMID- 4322456 TI - [Effect of some glutamine analogs and sulfhydryl group reagents on Clostridium welchii SR-12 glutaminase activity]. PMID- 4322458 TI - Influenza and the nervous system. PMID- 4322459 TI - Corticotrophin immunoassay. PMID- 4322460 TI - Neurological complications of so-called "influenza". A winter study in South-east Wales. AB - Acute neurological disorder followed an upper respiratory infection in 19 patients in south-east Wales during the winter of 1969-70. Spinal and radicular syndromes predominated and included seven cases of transverse myelopathy. Serological tests suggested that the preceding infection was due to influenza A virus in eight cases, to other viruses in six, and were negative in five. PMID- 4322461 TI - Immunoreactive corticotrophin levels in adrenocortical insufficiency. AB - Plasma concentrations of immunoreactive corticotrophin (ACTH) have been determined in 14 patients with untreated Addison's disease and in 42 patients with secondary adrenocortical insufficiency. Basal morning plasma ACTH levels were markedly raised in those with Addison's disease but were either in the normal range or undetectable in the group with secondary adrenocortical insufficiency. In the group with Addison's disease circulating ACTH values showed a definite nyctohemeral rhythm, a pronounced rise in response to insulin-induced hypoglycaemia, and an immediate fall following the intravenous injection of corticosteroids, with a half-life of between 13.5 and 44.2 minutes. When assays were performed with antisera directed against the portion of the ACTH molecule responsible for corticosteroidogenesis (the N-terminal portion) the apparent ACTH concentrations were lower than with antisera directed against the non steroidogenic (C-terminal) portion of the molecule. This emphasizes that different antisera may give different apparent hormone concentrations, and that the ranges of values obtained in normal and abnormal states must be established for each antiserum. PMID- 4322462 TI - A proposed histochemical and electron microscopic classification of human breast cancer according to cell of origin. PMID- 4322463 TI - Carcinoma of the biliary tract complicating chronic ulcerative colitis. PMID- 4322464 TI - Elevated antibody titers to Epstein-Barr virus in Hodgkin's disease. PMID- 4322465 TI - Nucleoside triphosphatase activity in the breast. PMID- 4322466 TI - Neoplastic argentaffin cells in gastric and intestinal carcinomas. PMID- 4322467 TI - [Seasonal variations in the blood corticosterone level in animals kept in groups and in isolation]. PMID- 4322468 TI - Stimulation of protein synthesis in unfertilized sea urchin and sand dollar eggs treated with trypsin. PMID- 4322469 TI - Observations on the lipolytic and melanotropic activities of the pineal gland. PMID- 4322470 TI - [Recent therapeutic conquests in extrapyramidal syndromes]. PMID- 4322471 TI - [Behavior of blood lipids in arthropathic subjects treated with mud baths]. PMID- 4322472 TI - [Adenovirus in the etiopathogenesis of acute enteritis in childhood]. PMID- 4322473 TI - [Pulmonary ultrastructure in oxygen poisoning at atmospheric pressure in rats]. PMID- 4322474 TI - [Abrikosov's tumor (apropos of 2 cases of gingival localization)]. PMID- 4322475 TI - The dissociation of aldosterone secretion and systemic renin and angiotensin II levels during the correction of sodium deficiency. PMID- 4322476 TI - Analysis of radioimmunoassay by disc electrophoresis and sucrose gradient centrifugation. PMID- 4322477 TI - Vasopressin-induced increase in peripheral plasma progesterone levels during early human pregnancy. PMID- 4322478 TI - Propranolol-blockade of vasopressin induced increase in plasma progesterone in early human pregnancy. PMID- 4322479 TI - Breast carcinoma and concurrent uveal melanoma. PMID- 4322480 TI - [Determination of the sitting height and age of anencephalics]. PMID- 4322481 TI - [Metastasis of mammary carcinoma in the opposite breast]. PMID- 4322482 TI - Differences in cytochrome oxidase and mitochondrial ATPase in melanotic and amelanotic melanoma. PMID- 4322483 TI - Central nervous system therapy and combination chemotherapy of childhood lymphocytic leukemia. PMID- 4322484 TI - [On the control of glomerular filtrate and tubular reabsorption efficiency during infusion of angiotensin II]. PMID- 4322485 TI - [Proteinuria caused by angiotensin: its prevention by abolishing the hypertensive response with diuretics]. PMID- 4322486 TI - Purification by molecular sieve chromatography on polyacrylamide Bio Gel P-300 of Clostridium histolyticum collagenase. PMID- 4322487 TI - A possible neuroendocrine system in polynoid polychaetes. PMID- 4322488 TI - Fine structure of the chemoreceptor sensillum in Limulus. PMID- 4322489 TI - Quantitative histology of changes with age in rat bone cortex. PMID- 4322490 TI - [Therapy of myasthenia gravis]. PMID- 4322491 TI - Interrelationship of the human intestinal flora and protein utilization. PMID- 4322492 TI - Immunohistochemical identification of pituitary hormone producing cells in the sockeye salmon (Oncorhynchus nerka, Walbaum). PMID- 4322493 TI - [ORL cylindromas and pseudo-cylindromas. Development and prognosis of true cylindromas. 32 cases observed more than 5 years ago]. PMID- 4322494 TI - [Cylindroma of the parotid gland and homolateral glomus jugulare]. PMID- 4322495 TI - [Morphogenesis and activity of the adrenocortical gland of normal and decapitated chick embryos]. PMID- 4322496 TI - Interrupting long-term patienthood: a cohort study. From the comfort of shelter to a taste for life? PMID- 4322497 TI - Adenocarcinoma of the head and neck. PMID- 4322498 TI - An improved technique for the preparation of isolated rat adrenal cells: a sensitive, accurate and specfic method for the assay of ACTH. PMID- 4322499 TI - Secretion of thyrocalcitonin in organ culture. PMID- 4322500 TI - Stimulation in vitro of lactic acid production by rodent adrenal glands. Effects of glucose, ACTH, 3',5'-cyclic AMP, ouabain, potassium, anaerobiosis and corticosterone. PMID- 4322501 TI - Lipolytic peptides in mammalian stomach and choroid plexus. PMID- 4322502 TI - Studies on the early interactions of growth hormone: effect in vitro on lipogenesis in adipose tissue. PMID- 4322503 TI - Studies of the measurement of bovine and porcine prolacting by radioimmunoassay and by systemic pigeon crop-sac bioassay. PMID- 4322504 TI - Intrarenal blood flow distribution in the rat, and the effect of angiotensin, noradrenaline and vasopressin. PMID- 4322505 TI - [Acromegaly]. PMID- 4322506 TI - The form and function of the Department of Psychiatry at the Mount Sinai Hospital. I. Clinical services. Aftercare. PMID- 4322507 TI - Evolving patterns of child psychiatry in a general hospital. PMID- 4322508 TI - Role of kidney tissue in metabolism of vitamin D. PMID- 4322509 TI - [The possible prophylactic and curative effects of flumidin (N1, N1-anhydrobis( hydroxyethyl)biguanide hydrochloride) on adenovirus infections]. PMID- 4322510 TI - [Electron microscopic study of conjunctival epithelium infected with adenoviruses]. PMID- 4322511 TI - [Carboxycathepsin--a key enzyme for 2 systems regulating blood pressure]. PMID- 4322512 TI - [Enteroviruses and adenoviruses in sewage. Demonstration methods and epidemiological study 1963-1965]. PMID- 4322513 TI - Incidence of the food poisoning clostridia in meat animals. PMID- 4322514 TI - The effects of Mg2+, Ca2+, ATP and cyclic 3',5'-AMP on the hormone-sensitive lipase of adipose tissue. PMID- 4322515 TI - [Endocrine system and blindness]. PMID- 4322516 TI - [Lupus erythematodes disseminatus and neurologic symptoms. Pathogenic relations]. PMID- 4322517 TI - N-acetylneuraminic acid analogues. II. The action of N-acetylneuraminic acid aldolase on 8-carbon and 7-carbon analogues. PMID- 4322518 TI - Effect of cell size on lipid synthesis by human adipose tissue in vitro. AB - When adipose tissue cells were incubated with collagenase for different periods of time, cell populations with different mean cell sizes were obtained from the same tissue sample. Lipid synthesis from glucose was studied as a function of adipose cell size and number. The incubations were performed in Parker medium 199, which is suitable for tissue culture of human adipose tissue. The results show that the larger cells of a specimen have a greater rate of lipid synthesis than the smaller cells of the same specimen. This is mainly due to an increase in the synthesis of glyceride-glycerol. Addition of insulin stimulated lipid synthesis. However, the larger adipose cells were less sensitive to the stimulating effect of insulin than the smaller cells. PMID- 4322519 TI - Effect of cell size on epinephrine- and ACTH-induced fatty acid release from isolated fat cells. AB - Free fatty acid release from fat cells, obtained from epididymal adipose tissue of rats of different sizes, was found to be dependent on the cell surface area, regardless of the age of the animals. The same result was found with cells of different sizes from the same animal. These results, when related to in vivo conditions, would indicate that for the same adipose tissue mass, activity would decrease with increasing cell size. On the other hand, the total activity of a given tissue would increase by increasing the size of its cells. PMID- 4322520 TI - [Reorganization of the brain mechanisms on the response to the repeated stress]. PMID- 4322521 TI - Stimulation of cell proliferation in mouse kidney by isoproterenol. PMID- 4322522 TI - Adenyl cyclase as a link between photon capture and changes in membrane permeability of frog photoreceptors. AB - Tomita has shown by electrophysiological measurements that the photoreceptors of the vertebrate retina are depolarized (excited) by darkness and hyperpolarized (inhibited) by light. Excitation is accompanied by an increase, and inhibition by a decrease, in the sodiumion permeability of the receptor cell. The retinal-rod outer segments of the frog contain an adenyl cyclase that is active in darkness and inactivated by light. This cyclase has a specific activity ten-times higher than the activity in previously described tissues. It is suggested that cyclic AMP is an intermediate in the light- and dark-induced changes in sodium permeability in the photoreceptor cell. PMID- 4322523 TI - Inhibition of the metabolism of 25-hydroxycholecalciferol by actinomycin D and cycloheximide. AB - Actinomycin D (or cycloheximide) administered prior to radioactive 25 hydroxycholecalciferol blocks the metabolism of 25-hydroxycholecalciferol to polar metabolites that accumulate in intestinal tissue, while it does not prevent the 25-hydroxylation of vitamin D(3) in the liver. Actinomycin D given after radioactive 25-hydroxycholecalciferol does not inhibit 25-hydroxycholecalciferol metabolism. These results indicate that 25-hydroxycholecalciferol must interact with the nuclei of cells to bring about the production of an enzyme(s) that converts it to its polar metabolites. PMID- 4322524 TI - Incidence of chick embryo lethal orphan virus antibody in the fowl (Gallus domesticus) in Britain. PMID- 4322525 TI - [Disinsertion of Starr's prosthesis]. PMID- 4322526 TI - [Pulmonary collagen diseases]. PMID- 4322527 TI - [Alveolar echinococosis of the liver. Immunologic diseases. Detection echography]. PMID- 4322528 TI - [Retroperitoneal mesenchymatous tumor. A case of lipogranuloxanthoma]. PMID- 4322529 TI - [Value of laparoscopy in the diagnosis of renal polycystosis]. PMID- 4322530 TI - [Arthroscopy of the knee joint. Current status of the question]. PMID- 4322531 TI - [Necrosing angeitis]. PMID- 4322532 TI - [Chorioretinal manifestations in hyperlipemia. Hyperlipemic retinopathy. 44 cases]. PMID- 4322533 TI - [Illness and death of Alexis I Comnenus]. PMID- 4322534 TI - [The epidemic of cholera in 1832 in Paris]. PMID- 4322535 TI - [Moliere's physicians and their models]. PMID- 4322536 TI - [Functional-morphological changes in the adrenal glands in some kidney diseases]. PMID- 4322537 TI - [Unusually large spherical liquid bodies in the ependyma and subependyma of the fire salamander]. PMID- 4322538 TI - [Lipid globes in the plexus epithelium of Rana temporaria L]. PMID- 4322539 TI - Lipid droplets in the lateral terminal nucleus of the accessory optic system in Galago (primates). PMID- 4322540 TI - Viruses isolated from appendicitis cases in childhood. PMID- 4322542 TI - The appearance of oxidoreductases in healing fractures. PMID- 4322541 TI - [Clinical behavior in hydatidiform mole]. PMID- 4322543 TI - Species specific differences in converting enzyme and in angiotensin I. PMID- 4322544 TI - Ultrastructure of granular cell myoblastoma. PMID- 4322545 TI - [Effects of high doses of vitamins on experimental hepatic necrosis]. PMID- 4322546 TI - [Neuro-radiological aspects of hypophyseal adenoma]. PMID- 4322547 TI - [Studies on swine. XXXI. Changes in serum magnesium levels after administration of ACTH and various adrenal cortex hormones]. PMID- 4322548 TI - Specific binding of 3H-angiotensin II in rabbit aorta. PMID- 4322549 TI - The metabolism of exogenous cyclic AMP at low concentrations by thymic lymphocytes. PMID- 4322550 TI - Amino acid composition and N-terminus of Pseudomonas cytochrome oxidase (= Pseudomas aerugenosa nitrite reductase). PMID- 4322551 TI - "Scar" carcinoma of the lung. PMID- 4322552 TI - P-enolpyruvate carboxylase from Plasmodium berghei. PMID- 4322553 TI - The effect of ACTH and corticosteroids on carbohydrate metabolism during the metamorphosis of Xenopus laevis. PMID- 4322554 TI - Localization and identification of corticotropin-producing cells in the distal lobe of the Rana temporaria pituitary gland. PMID- 4322555 TI - The cytodifferentiation of the rabbit pars distalis: an electron microscopic study. PMID- 4322557 TI - Cholangiocellular carcinoma with pulmonary metastasis in goat. PMID- 4322556 TI - [Treatment of dermatitis herpetiformis Duhring]. PMID- 4322558 TI - [Animal experimental and clinical findings in the therapeutic use of corticosteroids at various times of the day]. PMID- 4322559 TI - [Cytomegalo-virus infections in infants with blood exchange transfusions after birth]. PMID- 4322560 TI - [Rapid disappearance of a non-myelomatous IgG type dysglobulinemia during treatment with a synthetic corticostimuline]. PMID- 4322561 TI - [Cyclic A.M.P., messenger of the intracellular activity of some hormones]. PMID- 4322562 TI - ACTH-responsive, dexamethasone-suppressible adrenocortical carcinoma. PMID- 4322563 TI - The lower omo basin: geology, fauna and hominids of plio-pleistocene formations. PMID- 4322564 TI - [Effect of temporary interruption of the blood supply to the suprarenal gland on steroid biosynthesis and ACTH control of the adrenal cortex]. PMID- 4322565 TI - [Biology of tooth changes]. PMID- 4322566 TI - [Changes in some oxydizing ferments in blood serum and leukocytes in acute pneumonias in children]. PMID- 4322567 TI - [Pathology of ACTH secretion]. PMID- 4322569 TI - [Surgical treatment of disk hernia is not applied to so-called "refractory" sciatica]. PMID- 4322568 TI - [Histoenzymological changes in the albino rat adrenal during hormonal treatment]. PMID- 4322570 TI - [Correlation between hematosis abnormalities and renal function associated with attacks of asphyxia in chronic pulmonary insufficiency]. PMID- 4322571 TI - [New applications of thermovision in breast cancer]. PMID- 4322572 TI - [Sodium-free diet]. PMID- 4322573 TI - [Epidemiology of chronic virus infections]. PMID- 4322574 TI - [Clinical study of latent and chronic viral infections]. PMID- 4322575 TI - [Ulcerating gastric carcinoma]. PMID- 4322576 TI - Correlation between ultrastructure and histochemistry of lafora bodies. PMID- 4322577 TI - Rosenthal fibers, birefringent gliofibrillary changes and intracellular homogenous conglomerates in tissue cultures of gliomas. PMID- 4322578 TI - Variant malate dehydrogenase isoenzymes in mitochondrial populations. PMID- 4322579 TI - Glucagon and insulin release. Influence of drugs affecting the autonomic nervous system. PMID- 4322580 TI - [Succinate dehydrogenase and cytochrome oxidase activity in an injured sensory neuron]. PMID- 4322581 TI - X-zone degeneration in the adrenal glands of adult and immature female mice. PMID- 4322582 TI - The production of adenosine triphosphate in perfused giant axons of Loligo. AB - 1. The light production by squid giant axons perfused with solutions containing extract of firefly tails has been studied to give information about the production of ATP in such axons.2. An initial flash occurs when the perfusion fluid first enters the fibre. There is a secondary production of light, noticeable when the perfusion is halted, providing glutamate or aspartate are present in the perfusion medium.3. There is no secondary light production if glutamate is replaced by sulphate, succinate or alpha-ketoglutarate in the perfusion fluid.4. Ouabain has no effect whereas cyanide and oligomycin both block the secondary light production, the latter irreversibly.5. When the sodium outside the fibre is replaced by lithium or choline the secondary light production is often reduced and occasionally abolished.6. A raised internal sodium does not enhance secondary light production.7. The secondary light production is dependent upon the concentration of AMP in the perfusion solution.8. Fresh axoplasm generates a powerful light on immersion in perfusion fluid whereas dialysed axoplasm, even in the presence of added glutamate, generates no light whatever.9. The evidence, on balance, suggests that, under the conditions of the experiments described, there is no detectable reversal of active transport in perfused nerve fibres but that there is an enzyme system, probably membrane bound, capable of generating ATP from glutamate or aspartate and AMP by oxidative phosphorylation. The enzyme system can be inhibited by the replacement of external sodium. PMID- 4322583 TI - The diuretic actions of prostaglandin E1 and of noradrenaline, and the occurrence of a prostaglandin E1-like substance in the renal lymph of cats. AB - 1. The actions of noradrenaline, prostaglandin E(1) and angiotensin II-amide on various parameters of renal function and on the flow of renal lymph and its equivalent content of prostaglandin E(1)-like activity have been compared in cats under chloralose anaesthesia.2. All three compounds produced diuresis and natriuresis. Noradrenaline (0.1-0.3 mug/kg.min) and angiotensin II (0.1-0.2 mug/kg.min) with rise of the filtration fraction (FF) and GFR; prostaglandin E(1) (0.13-0.19mug kg.min) with increase in GFR but without change in FF. Noradrenaline and angiotensin markedly raised renal perfusion pressure, prostaglandin E(1) lowered it by approximately 10 mm Hg.3. All three compounds increased the renal lymph flow. Only PGE(1) and noradrenaline markedly raised the equivalent concentration of PGE(1) in the renal lymph.4. Complete block of alpha and beta adrenergic receptors prevented the vasopressor effect and the rise in FF caused by noradrenaline but did not markedly reduce the diuretic and natriuretic effects nor the influence on renal lymph.5. Effects of PGE(1) and of angiotensin were unaffected by alpha and beta adrenergic block and atropinization did not prevent the release of PGE(1)-like material or the diuresis caused by noradrenaline.6. It is suggested that the diuretic and natriutetic actions of noradrenaline are in large part attributable to the intrarenal action of this PGE(1)-like substance of unknown origin. PMID- 4322585 TI - Program profiles: a program for transition to independence. PMID- 4322584 TI - On the mode of action of ACTH on the isolated perfused adrenal gland. AB - 1. Isolated cat adrenal glands were perfused with Locke solution, and the corticosteroid outputs in response to adrenocorticotrophin (ACTH) were studied.2. Steroid outputs varied with the ACTH concentration, as well as with the duration of exposure to a given ACTH concentration.3. Omission of calcium from the perfusion medium markedly depressed ACTH-evoked steroid release. The steroid output was directly related to the extracellular calcium concentration up to 0.5 mM.4. During a constant exposure to ACTH, steroid output was maintained for at least 2-3 hr, provided that calcium was present in the perfusion medium.5. Strontium, but not barium or magnesium, replaced calcium in maintaining the secretory response to ACTH.6. Magnesium depressed ACTH-evoked secretion in the presence of calcium, and this depression of secretion was antagonized by increasing the calcium concentration.7. Prolonged perfusion with sodium-free or potassium-free solutions did not markedly inhibit steroid output in response to ACTH. Excess potassium (56 mM) did not produce a consistent or marked increase in spontaneous steroid output and did not affect the response to ACTH.8. The steroid content of adrenal glands perfused with Locke solution and exposed to ACTH was about 10% of the amount which was secreted. By contrast, adrenal glands perfused with calcium-free media and exposed to ACTH contained much higher amounts of steroid, despite the negligible amount secreted.9. These data suggest that calcium plays a critical role in the mechanism of corticosteroid secretion from the adrenal cortex. PMID- 4322587 TI - Size differences among the high molecular weight RNA's of avian tumor viruses. PMID- 4322586 TI - [Lymphographic findings in Paget's disease]. PMID- 4322588 TI - Isolation and characterization of proteins from Rous sarcoma virus. PMID- 4322589 TI - [Synthetic delayed-action ACTH in bronchial asthma]. PMID- 4322590 TI - [The effect of the C-lecithinase of Cl. perfringens type A on the blood and bone marrow of guinea pigs]. PMID- 4322591 TI - [Progressive paralysis (current problems concerning its clinical picture, course and therapy)]. PMID- 4322592 TI - Demodex folliculorum. Incidence and possible pathogenic role in the human eyelid. PMID- 4322593 TI - The incidence of cytomegalovirus infection among infants less than one year admitted to a paediatric department. PMID- 4322594 TI - Surveillance of acute viral respiratory diseases in children. PMID- 4322595 TI - Relaxing and metabolic actions of ACTH in rabbit colon. PMID- 4322596 TI - Conjoint action of sodium and angiotensin on brain mechanisms controlling water and salt balances. PMID- 4322597 TI - Chemical and biological effects associated with the iodination of angiotensin II. PMID- 4322598 TI - Cyclophophates. I. Effect of various cyclophosphates on phosphorylase b kinase activation. PMID- 4322599 TI - Adenyl cyclase in the toad bladder. PMID- 4322600 TI - [Effect of castration and testosterone on the activity of respiratory enzymes in rat's liver]. PMID- 4322601 TI - [Histological and histochemical studies on experimental D-3 hypervitaminosis]. PMID- 4322602 TI - [2 cases of arrhenoblastoma]. PMID- 4322603 TI - Home health aides program involves neighborhood women. PMID- 4322607 TI - Morphological transformation of Chinese hamster cells by dibutyryl adenosine cyclic 3':5'-monophosphate and testosterone. AB - Treatment of Chinese hamster ovary cells in vitro with dibutyrl adenosine cyclic 3':5'-monophosphate converts the culture from one of compact, randomly oriented cells that grow in multilayers to a monolayer of elongated, fibroblast-like cells growing parallel to one another. Testosterone propionate, which has a similar though smaller effect at high concentrations and after prolonged incubation, potentiates the action of dibutyryl cyclic AMP even when added at very low concentrations. The transformation is recognizable within one hour, affects cells throughout all or most of the life cycle, and is completely reversible. Both cell forms can reproduce, with approximately the same generation time. Agents like colcemid and vinblastine, which inhibit assembly of microtubules, prevent the transformation to the fibroblast-like form. It is postulated that the dibutyryl cyclic AMP and testosterone act by promoting organization of microtubules from protein monomers. PMID- 4322606 TI - Deoxyribonucleic acid polymerase associated with avian tumor viruses: secondary structure of the deoxyribonucleic acid product. AB - The products of the deoxyribonucleic acid (DNA) polymerase associated with Rous sarcoma virus and avian myeloblastosis virus were characterized by correlative analyses with equilibrium centrifugation and stepwise elution from hydroxyapatite. The initial enzymatic product consists of nascent DNA chains which are hydrogen-bonded to 70S viral ribonucleic acid (RNA), whereas the final enzymatic product is double-stranded DNA. Appreciable amounts of free single stranded DNA were not detected at any point during the course of the enzymatic reaction, but the data in this regard are not decisive. The time course of synthesis of DNA:RNA hybrids and double-stranded DNA has been analyzed. It is concluded that the synthesis of double-stranded DNA is a sequel to and is probably dependent upon the synthesis of DNA:RNA hybrid. PMID- 4322608 TI - Presynaptic neuromuscular inhibition by porphobilinogen and porphobilin. AB - The rat hemidiaphragm was studied in vitro as a test system to evaluate the effects of heme precursors and the uroporphyrins upon neuromuscular excitability. Porphobilinogen and porphobilin had no effect on the resting miniature end-plate potential frequency, but the K(+)-augmented frequency was significantly reduced. Porphobilin and porphobilinogen gave 50% of their maximal effect at concentrations of 0.008 and 0.6 mug/ml, respectively; the effect increased with concentration. Uroporphyrin I at 0.05-1.0 mug/ml caused a 25% decrease in frequency, but the effect did not increase with concentration. At similar concentrations, uroporphyrin III was without effect. The concentrations of porphobilin and porphobilinogen effective in inhibiting the K(+) stimulation, which are several orders of magnitude lower than the effective concentrations of simple amino acids, are those which might reasonably be expected in the sera of patients with acute intermittent porphyria. PMID- 4322609 TI - Restoration of several morphological characteristics of normal fibroblasts in sarcoma cells treated with adenosine-3':5'-cyclic monphosphate and its derivatives. AB - Sarcoma cells growing in tissue culture have morphological and growth characteristics different than normal fibroblasts. Several of the morphological characteristics of normal fibroblasts are regained when the cells are incubated with dibutyryl-cyclic AMP or butyryl-cyclic AMP (0.1-1 mM), or cyclic AMP (3 mM) plus theophylline (1 mM), but not with ATP, ADP, AMP, adenine, or adenosine (1-7 mM). The cell bodies become elongated; distinct narrow processes are formed. With prolonged incubation, the cells show less tendency to pile up or become polygonal. Further, L-929 and Rous sarcomatransformed hamster cells orient in parallel arrays characteristic of contact inhibition. The cells retain their altered morphology as long as the butyryl-cyclic AMP is present, but revert after its removal. Experiments with cycloheximide, puromycin, and actinomycin D indicate that protein Synthesis, but not RNA synthesis, is required for the response. Microtubular proteins may be involved. No response is observed with normal fibroblasts or with various epithelial cells. The data suggest that cyclic AMP may be an important factor in the determination of morphology of normal fibroblasts and this function may be lost or altered during transformation. PMID- 4322610 TI - [Enzyme histochemical studies on cold-preserved tissue]. PMID- 4322611 TI - [Study of mineralo-corticoid function in Addison's disease; apropos of 10 cases]. PMID- 4322612 TI - [Appearance of Crooke cells in hypophysis of infants after a treatment with ACTH]. PMID- 4322613 TI - [Characterization, isolation and properties of thyroid glycosidases: beta galactosidase, beta-N-acetylglucosaminidase and alpha-mannosidase]. PMID- 4322614 TI - Neonatal hepatic mitochondrocuprein. IV. Sulfitolysis of the cystine-rich crude copper protein and isolation of a peptide containing more than 35 percent half cystine. PMID- 4322615 TI - Demonstration of collagenolytic enzyme activity in human carious dentine. PMID- 4322616 TI - Insulin immunoassay by back-titration; some characteristics of the technic and the insulin precipitant action of alcohol. PMID- 4322617 TI - Synthesis of adenylyl-(3',5')-nucleosides, adenylyl-(3',5')-guanosine 2',3' cyclic phosphate, and oligoadenylic acids by ribonuclease U2. PMID- 4322618 TI - Studies on the respiratory system of Aspergillus oryzae. 3. Properties of mitochondria from mycelia grown in the presence of antimycin A. PMID- 4322620 TI - Vaccination against pediatric illness caused by parainfluenza virus, respiratory syncytial virus and certain adenoviruses. Current status and perspective. PMID- 4322619 TI - Regulation of hepatic glycogen synthetase of Rana catesbeiana. Effect ofinsulin and hydrocortisone on glycogen synthetase in a liver system in vitro, and regulation of glycogen synthetase by cellular metabolites. PMID- 4322621 TI - Chorangioma of the placenta. Chromosomal and electron microscopic studies. PMID- 4322622 TI - [Angiotensin infusion test in liver cirrhosis]. PMID- 4322623 TI - [Regulation of the body fluid by the kidney]. PMID- 4322624 TI - Conditional lethal mutants of avian sarcoma viruses. I. Physiology of ts 75 and ts 149. PMID- 4322626 TI - Ultrastructural studies of a herpesvirus of turkeys antigenically related to Marek's disease virus. PMID- 4322625 TI - Studies on the reproductive and cell-converting abilities of avian sarcoma viruses. PMID- 4322627 TI - Inactivation of avian sarcoma viruses with UV light: a difference between helper dependent and helper-independent strains. PMID- 4322628 TI - [Biological activity of ergocalciferol and cholecalciferol esters]. PMID- 4322629 TI - [Katamnestic studies on all lung tumors recorded in the district of Leipzig in the years 1963 and 1964]. PMID- 4322630 TI - Effects of theophylline and adenosine 3':5'-cclic monophosphate on growth hormone release from the isolated rat anterior pituitary gland. PMID- 4322631 TI - Role of adenosine 3':5'-cyclic monophosphate in the attion of octapeptide hormones. PMID- 4322632 TI - The co-ordinated inhibition of protein and lipid biosynthesis by adenosine 3':5' cyclic monophosphate. PMID- 4322633 TI - Adenosine 3':5'-cyclic monophosphate phosphodieterase: kinetic and inhibitor studies. PMID- 4322634 TI - 3':5'-cyclic nucleotide phosphodiesterase activity in mammalian tissues. PMID- 4322635 TI - A kinetic study of the enzymic hydrolysis of adenosine 3':5'-cyclic monophosphate. PMID- 4322636 TI - The functions of adenosine 3':5'-cyclic monophosphate. PMID- 4322637 TI - Inhibition of adenosine 3',5'-cyclic monophosphate phosphodiesterase. PMID- 4322638 TI - Evidence for oscillatory properties in the concentrations of adenosine 3':5' cyclic onophosphate produced by cardiac sarcoplasmic reticulum. PMID- 4322639 TI - The effects of theophylline on mucosubstance secretion by rous sarcoma cells. PMID- 4322640 TI - The transformation of lymphccytes by adenosine 3':5'-cyclic monophosphate, and consequent changes in histone microstructure. PMID- 4322641 TI - Action of adrenocorticotrophin on a preparation of isolated cells from rat adrenals. PMID- 4322642 TI - Adenosine 3':5'-cyclic monophosphate as the intracellular mediator of the action of adrenocorticotrophin on the adrenal cortex. PMID- 4322643 TI - The role of 3':5'-cyclic nucleotide phosphodiesterase in regulating tissue concentrations of adenosine 3':5'-cyclic mooophosphate. PMID- 4322644 TI - Adenylate cyclase and 'adenosine triphosphatase' in corpus luteum. PMID- 4322645 TI - A modified enzymic assay for adenosine 3':5'-cyclic monophosphate. PMID- 4322646 TI - The assay of adenosine 3':5'-cyclic monophosphate by aturation analysis. PMID- 4322647 TI - The effects of secretin, pancreozymin and acetylcholine on the concentration of adenosine 3':5'-cyclic monophosphate in cat pancreas. PMID- 4322648 TI - Adenosine 3':5'-cyclic monophosphate and insulin release. PMID- 4322649 TI - Ascorbic acid deficiency and pituitary adrenocortical activity in the guinea-pig. AB - 1. Guinea-pigs kept on a diet deficient in ascorbic acid lost weight and became moribund in about 24 days.2. The adrenal ascorbic acid concentration fell rapidly during the first 2 weeks, and the plasma corticosteroid concentration and 17 oxogenic steroid excretion rose sharply in the third week of ascorbic acid deficiency.3. Both histamine and corticotrophin increased the plasma corticosteroid concentration when injected during the second week but failed to change the pre-existing high concentration of the steroid in the third week of ascorbic acid deficiency.4. The observations confirm that ascorbic acid is not involved in corticoidogenesis and that scurvy is a severe stress which increases adrenocortical activity to such an extent that the rate of synthesis of corticosteroids is incapable of matching the rate of their release. PMID- 4322650 TI - [Etiologic problem raised by malignant gelatinous ascites]. PMID- 4322651 TI - [Steroid diabetes in viral hepatitis and other diseases]. PMID- 4322652 TI - A sensitive technique for detecting and estimating the peptide hormone angiotensin-II-beta-amide and its antibodies by using chemically modified bacteriophage and activated sepharose. PMID- 4322653 TI - [Changes of some biochemical indicators in experimental hypertension induced with a saline diet in rats]. PMID- 4322654 TI - [Plasma levels of ACTH and cortisol in man during anesthesia and surgery]. PMID- 4322655 TI - [Interrelation in the secretions of anterior pituitary hormones]. PMID- 4322656 TI - [Responses of plasma pituitary hormones to various stimuli]. PMID- 4322657 TI - [Variation of hypothalamic content of corticotropin-releasing factor (CRF) in the regulation of ACTH secretion]. PMID- 4322659 TI - [ACTH secreting cells]. PMID- 4322658 TI - [Cellular source of anterior pituitary hormones]. PMID- 4322660 TI - [Treatment of Cushing's syndrome due to pituitary ACTH excess]. PMID- 4322661 TI - Observations on the water and electrolyte composition of the iguanid lizard Dipsosaurus dorsalis (Baird & Girard), with special reference to the control by the pituitary gland and the adrenal cortex. PMID- 4322662 TI - [Effect of ablation of the corpuscles of Stannius on interrenal function in the eel (Anguilla anguilla L)]. PMID- 4322663 TI - In vitro assay of MSH using skin from the frog Hyla arborea. PMID- 4322664 TI - Angiotensin II in arterial and renal venous plasma and renal lymph in the dog. AB - Angiotensin II was determined by radioimmunoassay in systemic arterial, pulmonary arterial, and renal venous plasma and in renal hilar lymph in dogs. Levels of the peptide were determined prior to and during progressive graded hemorrhage or reduction in renal perfusion pressure. Levels of angiotensin II in plasma consistently rose during transit through the lung indicating pulmonary conversion of angiotensin I to angiotensin II. On the other hand, angiotensin II in the renal vein plasma was less than that in arterial plasma indicating renal extraction of the peptide from plasma. When renal hilar lymph was sampled under similar conditions, angiotensin II in lymph was consistently higher than that in arterial or renal venous plasma. Furthermore, in some experiments angiotensin II in lymph increased at a time when the concentration in plasma was undetectable. No evidence was found to indicate that angiotensin II in plasma entered renal lymph. It was concluded that angiotensin II levels in lymph reflected the concentration of angiotensin II in renal tissue. The data further suggested that angiotensin II is partially removed from arterial plasma by hydrolysis during transit through the kidney. PMID- 4322667 TI - [Gastrointestinal ulcers arising during hormone therapy]. PMID- 4322666 TI - Studies on hyperkalemic periodic paralysis. Evidence of changes in plasma Na and Cl and induction of paralysis by adrenal glucocorticoids. AB - In a 19 yr old male with familial hyperkalemic periodic paralysis, paralysis was consistently induced by the administration of potassium chloride, corticotropin gel, and a variety of glucocorticoids (dexamethasone, 6-methylprednisolone, triamcinolone) but not by mineralocorticoids (D-aldosterone, deoxycorticosterone) or by adrenocorticotropin (ACTH)-gel plus metyrapone. Induced attacks were virtually identical with spontaneous attacks, being associated, after a latent period of a few hours, with a rise in plasma K(+) and HCO(3) (-) and a simultaneous fall in plasma Na(+) and Cl(-) concentrations to an extent implying exchange of 1 K(+) with 2 Na(+) and 2 Cl(-) between extracellular and intracellular fluid. ACTH-induced paralysis was preceded by rising serum inorganic P, and associated with increased plasma glucose, blood lactate, and serum creatine phosphokinase concentrations. In normal subjects ACTH, cortisol, and triamcinolone administration failed to change plasma electrolytes or strength, while ingestion of KCl produced no weakness and smaller changes in plasma K and Na than in the patient.Since the patient and normal subjects showed the same changes in renal excretion of K after the administration of cortisol and KCl, it seems likely that paralysis in the patient resulted from abnormally slow uptake (and/or excessive loss) of K by the muscle cells, possibly caused by an abnormal "ion-exchange pump." Normal adrenocortical function and absence of a peak in plasma 11-hydroxycorticoid (11-OHCS) concentration preceding spontaneous paralysis, indicated that spontaneous paralysis did not result from changes in cortisol secretion. Similar hyperkalemic paralysis was precipitated by ACTH-gel in a brother and first cousin of the propositus. Administration of acetazolamide and fludrocortisone reduced the rise in plasma K concentration and prevented the weakness which otherwise invariably followed KCl administration to the patient. He and two close relatives have been completely protected from severe attacks of paralysis in the past 14 months by treatment with these two medications. PMID- 4322665 TI - Cyclic 3',5'-adenosine monophosphate in human blood platelets. II. Effect of N6 2'-o-dibutyryl cyclic 3',5'-adenosine monophosphate on platelet function. AB - The relation of cyclic 3',5'-adenosine monophosphate to platelet function has been studied by investigating the influence of this compound and of its N(6)-2'-0 dibutyryl derivative on platelet aggregation and other aspects of platelet behavior after demonstration of adenyl cyclase activity in disrupted platelets. Dibutyryl cyclic AMP inhibited platelet aggregation induced by ADP, epinephrine, collagen, and thrombin. Cyclic AMP was also inhibitory but was less effective. The platelet "release reaction" was also inhibited; specifically, there was inhibition of the induction of platelet factor 3 activity and of the release of labeled 5-hydroxytryptamine. Platelet swelling produced by ADP was not inhibited. The action of dibutyryl cyclic AMP did not result from contamination with 5'-AMP, nor was it attributable to production of 5'-AMP by plasma enzymes. Dibutyryl cyclic AMP was degraded to 2'-O-monobutyryl cyclic AMP and to cyclic AMP in plasma, but plasma exhibited no cyclic nucleotide phosphodiesterase activity, and the production of 5'-AMP did not occur. The in vitro effects of dibutyryl cyclic AMP were associated with uptake of the compound by platelets. Adenyl cyclase activity of platelet homogenates was demonstrated with production of 9.27 x 10( 11) (+/-2.62 x 10(-11)) mole cyclic AMP per min per 10(10) platelets. The activity was increased by NaF and by prostaglandin PGE(1) and was decreased by epinephrine. The effect of epinephrine was blocked by phentolamine but not by propanolol. Adenyl cyclase activity was also inhibited by collagen, 5 hydroxytryptamine, and thrombin. ADP, dibutyryl cyclic AMP, and cyclic AMP did not alter adenyl cyclase activity. These observations are consistent with the hypothesis that platelet aggregation is favored by a decrease in platelet cyclic AMP and inhibited by an increase in cyclic AMP. PMID- 4322668 TI - [Daily rhythm of excretion of 17-hydroxycortico(17-ketogenic) steroids and 17 ketosteroids in lung cancer]. PMID- 4322670 TI - Morphologic studies of human subcutaneous adipose tissue in vitro. PMID- 4322671 TI - Carcinoma of the lung. A comparative series of 687 cases. PMID- 4322673 TI - Accelerated appearance of osmiophilic bodies in fetal lungs following steroid injection. PMID- 4322672 TI - 3-methyl salicylic acid: a long acting salicylate which decreases free fatty acid mobilisation and plasma cholesterol. PMID- 4322674 TI - Malabsorption and growth failure due to intestinal enterokinase deficiency. PMID- 4322675 TI - [Symposium of lung doctors. 5. Relaxing effect of ACTH on human bronchi in vitro]. PMID- 4322676 TI - Primary carcinoma of the fallopian tube. PMID- 4322677 TI - Ultrastructure and histochemistry of the ultimobranchial body of fresh-water turtles. PMID- 4322679 TI - Studies on norepinephrine-containing afferents to Purkinje cells of rat cerebellum. 3. Evidence for mediation of norepinephrine effects by cyclic 3',5' adenosine monophosphate. PMID- 4322680 TI - Discharge diets versus patient education. PMID- 4322681 TI - Effect of posterior pituitary extracts and stimulation of midbrain reticular formation on ACTH in rats with hypothalamic lesion. PMID- 4322682 TI - Change of angiotensin II-like activity in arterial blood induced by haemorrhage in immature and adult rabbits. PMID- 4322683 TI - [Plate agar medium for spore formation of Clostridium perfringens]. PMID- 4322684 TI - A method for the measurement of plasma renin in the rat. PMID- 4322685 TI - Comparison of activity of 25-hydroxycholecalciferol and dihydrotachysterol in the thyroparathyroidectomized rat. PMID- 4322686 TI - Studies on the leukocytopenia due to acute effects of supernatant fluids of Bordetella pertussis cultures. PMID- 4322687 TI - The influence of buffers on human platelet aggregation and energy metabolism. PMID- 4322688 TI - Endotoxin fever and tolerance in totally adrenalectomized rabbits. PMID- 4322689 TI - Isolated adrenal cells: corticosterone production in response to cyclic AMP (adenosine-3',5'-monophosphate). PMID- 4322690 TI - Isolated adrenal cells: assay of ACTH in rat serum. PMID- 4322691 TI - Cobalt-60 teletherapy of pituitary adenomas. PMID- 4322692 TI - Effect of reduced nicotinamide adenine dinucleotide phosphate (NADPH) and adrenal corticotrophic hormone (ACTH) on steroidogenesis by intact and sectioned rat adrenals. PMID- 4322693 TI - The mode of action of cyclic AMP as a contraceptive. PMID- 4322694 TI - The ultrastructure of the human adrenal medulla: with comparative studies of white rat. PMID- 4322695 TI - Stimulation by thyrotropin, long-acting thyroid stimulator, and dibutyryl 3',5' adenosine monophosphate of protein and ribonucleic acid synthesis and ribonucleic acid polymerase activities in porcine thyroid in vitro. PMID- 4322696 TI - Stimulation by adenosine 3',5'-cyclic monophosphate of protein synthesis by adenohypophyseal polyribosomes. PMID- 4322697 TI - Cyclic nucleotide-dependent protein kinases. V. Preparation and properties of adenosine 3',5'-monophosphate-dependent protein kinase from various bovine tissues. PMID- 4322698 TI - Breast cancer in elderly women. PMID- 4322699 TI - Parathyroidectomy and the induction of thymic atrophy in normal, adrenalectomized and orchidectomized rats. PMID- 4322700 TI - [Recent advances in surgery of the hypophysio-hypothalamic lesions]. PMID- 4322701 TI - Renin-angiotensin activity in hypertensive rats with a single ischemic kidney. PMID- 4322702 TI - An electron microscopic study of metaplasia of the rat tracheal epithelium in vitamin A deficiency. PMID- 4322703 TI - Microbodies in experimentally altered cells. 8. Continuities between microbodies and their possible biologic significance. PMID- 4322704 TI - Electron microscopic observations on acute bilirubin encephalopathy in Gunn rats induced by sulfadimethoxine. PMID- 4322705 TI - Specificity of the humoral and pathological response to Marek's disease virus. PMID- 4322706 TI - Adenosine 3',5'-monophosphate in nervous tissue: increase associated with synaptic transmission. AB - Brief periods of stimulation of the preganglionic nerve fibers produced a severalfold increase in the content of adenosine 3',5'-monophosphate in superior cervical sympathetic ganglia, whereas postganglionic stimulation did not. These and other experiments indicated that the increased concentrations of adenosine 3'5'-monophosphate were closely associated with the process of synaptic transmission. This increase occurred primarily in postsynaptic cells. PMID- 4322707 TI - Steroid hormone formation in the human ovary. VII. Stability of the profile of radioactive steroids formed from acetate-1-14C by the corpus luteum in vitro. PMID- 4322708 TI - [Nosological differentiation of so-called acute nonspecific mesoadenitis in children]. PMID- 4322710 TI - Intracytoplasmatic Russell-bodies and "protein crystals" in LPC-1 mouse plasmacytoma. PMID- 4322711 TI - [Medullary circulatory insufficiency revealed by arteriography of the spinal cord]. PMID- 4322709 TI - [Ultrastructural and cytochemical studies on the pigment of a case of Dubin Johnson's disease]. PMID- 4322712 TI - Kinetics of the human renin and human substrate reaction. PMID- 4322713 TI - Adenyl cyclase and cyclic AMP. Biochemical links in the regulation of myocardial contractility. PMID- 4322714 TI - Conformation of cytochromes. V. Cytochrome c oxidase. PMID- 4322715 TI - The enthalpy of hydrolysis of various 3',5'-and 2',3'-cyclic nucleotides. PMID- 4322716 TI - Substrate specificity and aspects of deamination catalyzed by rabbit muscle 5' adenylic acid aminohydrolase. PMID- 4322717 TI - Cross-reactions of adenosine 3',5'-monophosphate-dependent protein kinase systems from rat liver and rabbit skeletal muscle. PMID- 4322718 TI - The origin and fate of microbodies in the fat body of an insect. AB - The structure and life history of insect microbodies are described during the development of the fat body from the 4th to 5th larval molt through the 5th to pupal molt. The mature microbodies are flattened spheres about 1.1 x 0.9 micro, with a depression on one side where a dense mass connects the limiting membrane to the core of coiled tubules. They contain catalase and urate oxidase. The precise synchrony of development of insect cells during the molt/intermolt cycle makes it easy to study the life history of particular organelles. Phases of growth are correlated with the hormonal milieu. Mature 4th stage microbodies decrease in size before ecdysis to the 5th stage when they atrophy at the same time as the new 5th stage generation arises. The 5th stage microbodies form as diverticula of the RER and, grow while confronted by RER cisternae. The mature microbodies decrease in size when the fat body engages in massive larval syntheses. At the end of the 5th larval stage, the microbodies are invested by isolation membranes and destroyed before pupation. There are thus two mechanisms for microbody destruction: atrophy of the 4th stage organelles and isolation with autophagy at the end of the 5th stage. PMID- 4322719 TI - The effects of iron deficiency on the hepatocyte: a biochemical and ultrastructural study. AB - Effects of iron deficiency on the hepatocyte were studied quantitatively in the rat by combining ultrastructural and biochemical techniques. After 3-8 wk of an iron-deficient diet, the percentage of cytoplasm occupied by mitochondria increased progressively compared with complete diet values. The increment resulted primarily from an enlargement of individual mitochondria rather than from an increased mitochondrial number. Many mitochondria were completely divided by a double membrane, often at a point of constriction. After 2 days of iron administration, mitochondria were of heterogeneous size, shape, and electron opacity. After 5 days, essentially all mitochondria had become normal in configuration. The rate of reversal of the morphological abnormality was more rapid than would be anticipated if it coincided with known rates of renewal of mitochondrial DNA or protein. The concentrations of mitochondrial cytochromes were more rapidly depressed as a result of iron deprivation than those of microsomal cytochromes. Cytochromes c and a were decreased after 3 and 8 wk of exposure to the deficient regimen. Cytochrome P 450 was not decreased after a 3 wk exposure to the deficient diet and responded normally to phenobarbital treatment with a fourfold increase in total hepatic content; its concentration was depressed only after 8 wk of exposure to the deficient diet. There was no reduction in cytochrome b(5) concentration. PMID- 4322720 TI - Mode of action of parathyroid hormone and cyclic adenosine 3',5'-monophosphate on renal tubular phosphate reabsorption in the dog. AB - To evaluate the effects of parathyroid hormone and cyclic adenosine monophosphate on proximal tubular sodium and phosphate reabsorption, micropuncture studies were performed on dogs that received a highly purified preparation of parathyroid hormone (PTH), dibutyryl cyclic 3',5'-adenosine monophosphate (cyclic AMP), 5' AMP, and saline. PTH resulted in a 30-40% inhibition of sodium and phosphate reabsorption in the proximal tubule unassociated with a rise in either total kidney or single nephron glomerular filtration rate (GFR). The bulk of the phosphate rejected proximally was excreted in the final urine while sodium excretion rose minimally despite the marked proximal inhibition, consistent with the presence of reabsorptive sites in the distal nephron for sodium but not phosphate. The infusion of dibutyryl cyclic AMP either systemically or directly into the renal artery inhibited proximal sodium and phosphate reabsorption in the absence of changes in either total kidney or single nephron GFR, resembling the effects of PTH quantitatively and qualitatively. In contrast, another adenine nucleotide, 5'-AMP, did not inhibit the reabsorption of either sodium or phosphate. These observations support the thesis that renal effects of PTH are mediated via stimulation of renal cortical adenyl cyclase. The infusion of a moderate saline load, 25 ml/kg, also produced a similar inhibition of proximal tubular fractional sodium and phosphate reabsorption with a marked phosphaturia but only minimal natriuresis. Thus, changes in sodium and phosphate reabsorption occur in parallel in the proximal tubule when sodium reabsorption is inhibited either with volume expansion or with administration of "specific" phosphaturic agents such as PTH or cyclic AMP. These data are consistent with the thesis that phosphate reabsorption is dependent upon proximal tubular sodium reabsorption wherein the phosphaturic effect of PTH might be the result of a primary inhibition of proximal tubular sodium reabsorption mediated by adenyl cyclase stimulation. PMID- 4322721 TI - Deposition in and release of vitamin D3 from body fat: evidence for a storage site in the rat. AB - Vitamin D in all body tissues was radio-labeled by supplementing completely vitamin D-deficient weanling rats with oral vitamin D(3)-4-(14)C for 2 wk. All vitamin D was then withheld, and radioactivity and vitamin D content in a variety of organs and tissues were measured. Adipose tissue was found to contain by far the greatest quantity of radioactivity throughout the 3 month experimental period. Immediately after supplementation, half of the total radioactivity in adipose tissue corresponded to unaltered vitamin D(3), and the other half to polar metabolites and esters of vitamin D(3) and unidentified peak II. 1 month later there was approximately the same proportion but a decrease in the total quantity of each form. We conclude that adipose tissue is the major storage site for vitamin D(3) in its several forms. Unaltered vitamin D(3) was the principal storage form observed and presumably a source available for conversion to other metabolites during deprivation. PMID- 4322722 TI - Pyrimidine-specific antibodies: reaction with DNA's of differing base compositions. PMID- 4322723 TI - Drinking induced by injection of angiotensin into the rain of the rat. AB - 1. When applied directly to the brain, angiotensin II amide, as either the valine(5) octapeptide, causes rats in normal fluid balance to drink water.2. The drinking response to angiotensin injections is copious, rapid, repeatable within the same test session, and stable over months of testing in the same animal.3. The response is motivationally potent and specific. After injection the animals move directly to the source of water and drink. There is typically no preliminary hyperactivity or subsequent depression. The animals do not eat, gnaw or exhibit other behaviours that are not normally seen during spontaneous drinking. The injections rouse sleeping animals to drink and interrupt eating in animals deprived of food for two days.4. The region of the brain that is most sensitive to angiotensin includes the anterior hypothalamus, the preoptic region, and the septum including the nucleus accumbens.5. Intracranial renin elicited drinking. Bradykinin and vasopressin did not, nor did adrenaline, noradrenaline or aldosterone. In the most sensitive region, sites positive for angiotensin also yielded drinking to carbachol.6. Responses were obtained with 5 ng (ca. 5 p-mole) and occurred reliably with 50 ng angiotensin or more. The dose-response curve for amount drunk rose from 5 to 100 ng and levelled off thereafter. Angiotensin is therefore the most potent dipsogen known and is effective at doses that are reasonably within the concentration range for circulating endogenous angiotensin.7. Injections into the sensitive region of doses of angiotensin that were effective for drinking did not produce peripheral haemodynamic changes in lightly anaesthetized rats.8. This work strengthens the suggestion that angiotensin is a natural hormone of drinking behaviour that participates in extracellular thirst by its release from the kidney and subsequent direct action on a specific chemoreceptive region in the anterior diencephalon and limbic lobe. PMID- 4322725 TI - Nursing education: "the Clarnnda Plan". PMID- 4322726 TI - Psychiatrcc aids learn from ex-patients. PMID- 4322724 TI - Sodium transport across the isolated epithelium of the frog skin. AB - 1. A method to separate the epithelium from the underlying layers of the frog skin is described. The method is based on the combined use of collagenase and hydrostatic pressures.2. The potential difference and the short-circuit current values of isolated epithelia and whole skins are similar. Na net flux and short circuit current are equivalent.3. The time course of changes in potential following rapid changes in composition of the bathing solutions shows that the barrier to K diffusion at the internal surface of the isolated epithelium is larger than the barrier to Na diffusion at the external surface.4. In the isolated epithelium there are 133 m-mole K(+) and 24.7 m-mole Na/l. cellular water. The amount of extracellular water was considered to be equal to the inulin space.5. Arginine vasopressin (0.1 u./ml.) markedly increased short-circuit current and potential difference in isolated epithelia. The amount of Na in the epithelium that equilibrated with Na in the external solution was not increased by the hormone.6. Ouabain (10(-4)M) reduced short circuit current and potential difference to values close to zero. The ouabain treated epithelia contained an increased amount of Na originating in the internal solution. On the other hand the amount of Na that originated from the external solution was not increased.7. The amount of epithelial Na that equilibrated with Na in the external solution was 0.009 mu-equiv/cm(2). This figure is about ten times smaller than the values found in whole skins. PMID- 4322727 TI - Clinical specialist in the community mental health program. PMID- 4322728 TI - The role of the nurse in suicide prevention. PMID- 4322729 TI - The treatment of the aged in state hospitals. PMID- 4322730 TI - Trends in maternal and child health. A report from the WHO European Regional Office. PMID- 4322731 TI - Deferring attention to institutions for the mentally retarded while emphasizing development of community resources. PMID- 4322732 TI - The mental health benefits of Medicare. PMID- 4322733 TI - The utilization of nursing staff in a psychiatric research project. PMID- 4322734 TI - [A case of idiopathic pulmonary hemosiderosis]. PMID- 4322735 TI - Stability of cellular forms in supratentorial gliomas. PMID- 4322736 TI - Problems in contraception. PMID- 4322737 TI - Danger of polymyxin B inhalation. PMID- 4322739 TI - [Effect of prodigiozan on the course of burns in dogs]. PMID- 4322738 TI - [Development and study of media for the biocontrol of the activity of antibiotics by the agar diffusion method]. PMID- 4322740 TI - [Toxicity of levorin to pregnant rats and their fetus]. PMID- 4322741 TI - [Sensitivity of clinical strains of Ps. aeruginosa to aminoglycoside antibiotics, carbenicillin and their combinations]. PMID- 4322742 TI - A dipeptidyl carboxypeptidase that converts angiotensin I and inactivates bradykinin. PMID- 4322743 TI - Improved methods for preparing pure gibberellins from cultures of Gibberella fujikuroi. Isolation by adsorption or partition chromatography on silicic acid and by partition chromatography on Sephadex columns. PMID- 4322744 TI - Sex hormone control mechanisms. II. Influence of estrogen and progesterone on the activities of key enzymes involved in the carbohydrate metabolism of chicken (Gallus domesticus) oviducts. PMID- 4322745 TI - Structural investigations on a cell-wall lipopolysaccharide from Neisseria sicca. PMID- 4322746 TI - Granular cell myoblastoma of the cystic duct: report of a case with electron microscope observations. PMID- 4322747 TI - Lactation following thoracotomy. PMID- 4322748 TI - Comparison of the mitochondrial membrane proteins in rat liver and hepatomas. PMID- 4322749 TI - Ultrastructural alterations within hyperplastic liver nodules induced by ethionine. PMID- 4322750 TI - Identification of three-line electron spin resonance signal and its relationship to ascites tumors. PMID- 4322751 TI - Differences in tumor types and organ susceptibility in BALB-c and RF mice following dimethylnitrosamine and diethylnitrosamine. PMID- 4322752 TI - [Anterior pituitary gland function test. 1. ACTH secretory function test]. PMID- 4322753 TI - Colitis cystica profunda concurrent with and differentiated from mucinous adenocarcinoma: report of a case. PMID- 4322754 TI - [Present state of research on the etiology of viral hepatitis]. PMID- 4322755 TI - [Cytomegaly-virus infection in hemodialysed patients]. PMID- 4322756 TI - [Experiences with malignant tumors of the gallbladder]. PMID- 4322757 TI - Isolation of bovine enteroviruses. PMID- 4322758 TI - Electron spin resonance studyof radicals derived from simple amines and amino acids. PMID- 4322759 TI - Characterization and triplet-state electron paramagnetic resonance spectra of the binuclear (molybdenum(V))2--glutathione complex. An example of molybdenum- polypeptide complexes. PMID- 4322760 TI - Quantitative characterization of dense body, autophagic vacuole, and acid phosphatase-bearing particle populations during the early phases of glucagon induced autophagy in rat liver. AB - Quantitative characterization of dense body, autophagic vacuole and acid phosphatase-bearing particle populations of rat liver have been made at 10 min intervals during the first 50 min following the intraperitoneal administration of glucagon. Beginning 10 to 20 min postinjection, increases in the number of autophagic vacuoles and in the osmotic sensitivity of acid phosphatase-bearing particles were observed, associated with a progressive disappearance of dense bodies. These changes appeared to reach a maximum 50 min after treatment. The average volume of autophagic vacuoles was found to be 440-870% greater than that of normal dense bodies during this time period. No consistent change in total acid phosphatase activity was noted. A detailed study of autophagic vacuole profile populations revealed the presence of five different types of profiles, two of which, types I and II, accounted for 76.3-94.4% of the profiles examined. Type I profiles primarily contained elements of the endoplasmic reticulum, free ribosomes, and ground cytoplasm. Type II profiles had mitochondrial profiles as their principal constituent, but endoplasmic reticulum and free ribosomes were also seen. At all time points type I profiles predominated, comprising 55-69% of the profiles found. Both profile types were bounded by single and double limiting membranes, the former being predominate. A time-dependent change in the ratio of single to double membrane-limited profiles could not be demonstrated. Morphometric parameters derived from profile size distributions indicated that the number of types I and II autophagic vacuoles increased with time, the rate being greater for the type II particle, except between 40 and 50 min. The average volume of the type II autophagic vacuole was consistently greater than that of the type I. PMID- 4322761 TI - Cardiolipin content of wild type and mutant yeasts in relation to mitochondrial function and development. AB - The phospholipid composition of various strains of the yeast, Saccharomyces cerevisiae, and several of their derived mitochondrial mutants grown under conditions designed to induce variations in the complement of mitochondrial membranes has been examined. Wild type and petite (cytoplasmic respiratory deficient) yeasts were fractionated into various subcellular fractions, which were monitored by electron microscopy and analyzed for cytochrome oxidase (in wild type) and phospholipid composition. 90% or more of the phospholipid, cardiolipin was found in the mitochondrial membranes of wild type and petite yeast. Cardiolipin content differed markedly under various growth conditions. Stationary yeast grown in glucose had better developed mitochondria and more cardiolipin than repressed log phase yeast. Aerobic yeast contained more cardiolipin than anaerobic yeast. Respiration-deficient cytoplasmic mitochondrial mutants, both suppressive and neutral, contained less cardiolipin than corresponding wild types. A chromosomal mutant lacking respiratory function had normal cardiolipin content. Log phase cells grown in galactose and lactate, which do not readily repress the development of mitochondrial membranes, contained as much cardiolipin as stationary phase cells grown in glucose. Cytoplasmic mitochondrial mutants respond to changes in the glucose concentration of the growth medium by variations in their cardiolipin content in the same way as wild type yeast does under similar growth conditions. It is concluded that cardiolipin content of yeast is correlated with, and is a good indicator of, the state of development of mitochondrial membrane. PMID- 4322763 TI - Determination of tritium in microgram tissue samples: distribution of exogenous 3H-cholesterol in the rat adrenal cortex. PMID- 4322764 TI - Activation of hormone-sensitive lipase in extracts of adipose tissue. AB - Rat adipose tissue was homogenized in 0.154 m KCl, and the supernatant fluid, obtained after centrifugation at 15,000 g, was extracted with benzene to remove triglycerides. Most of the lipase activity in the extracted fluid was precipitated with ammonium sulfate between 15 and 40% saturation. The specific activity of the lipase in this fraction was about three times that in the benzene extracted supernatant fluid. The specific activity of the monoglyceride esterase was increased to a lesser extent. Lipase activity in the benzene-extracted fluid and in the ammonium sulfate fraction was increased 15-45% by incubation with 0.3 mm ATP, 10 mm MgCl(2), and 0.03 mm cyclic AMP for 10 min before assay. None of these compounds alone or in combinations of two was as effective as all three together. The specific activity of the 15-40% ammonium sulfate fraction prepared from fat cells exposed to epinephrine and glucagon was greater than that from portions of the same cell pool not exposed to hormones. In addition, the already elevated lipase activity in preparations from hormone-treated cells was not enhanced by incubation with ATP, MgCl(2), and cyclic AMP. Thus, it seems probable that the lipase activity in the ammonium sulfate fractions represents, at least in part, hormone-sensitive lipase. PMID- 4322765 TI - Biosynthesis of presqualene pyrophosphate by liver microsomes. AB - Microsomes from rat liver have been shown to synthesize a squalene precursor from farnesyl pyrophosphate. This intermediate is identical with presqualene pyrophosphate, a 30-carbon cyclopropane containing pyrophosphate ester that had previously been isolated from yeast. The squalene precursor was found to be tightly, but not covalently, bound to microsomes. PMID- 4322766 TI - Enhancement of synaptic transmission by dendritic potentials in chromatolysed motoneurones of the cat. AB - 1. Monosynaptic transmission in cat lumbosacral motoneurones undergoing chromatolysis was studied by intracellular recording from 7 to 20 days after section of the appropriate ventral roots.2. The average input resistance measured by passing polarizing currents across the cell membrane showed no significant difference between normal and chromatolysed motoneurones. Average rheobasic current for chromatolysed motoneurones was significantly lower (by about 30%) than that for normal motoneurones.3. Spike-like partial responses were commonly superimposed on monosynaptic EPSPs in chromatolysed motoneurones. These responses could be eliminated by stimulation of the bulbar inhibitory reticular formation, but could not be blocked by hyperpolarization applied to the motoneurone soma.4. The spike-like partial response in chromatolysed motoneurones showed a refractory period following (i) the antidromic invasion of the neurone generated by ventral root stimulation, and (ii) in response to two successive afferent stimuli. The refractory period ranged from 5 to 13 msec.5. Initiation of the partial response had no direct relation with the amplitude of the underlying EPSP. The partial response could be evoked by small EPSPs of about 0.5 mV.6. The action potential of a chromatolysed motoneurone arose from the partial response at different levels of depolarization, showing multiple trigger zones for spike initiation. Occasionally, chromatolysed motoneurones discharged in response to stimulation of a single afferent fibre.7. In neurones where more than one spike-like response was obtained, interaction between dendritic responses showed no refractoriness.8. It is concluded that the partial response is an all-or-none event originating at some discrete site on dendrites, and that its presence increases the efficacy of synaptic excitation in chromatolysed motoneurones. PMID- 4322767 TI - Alterations of synaptic action in chromatolysed motoneurones of the cat. AB - 1. Monosynaptic EPSPs in lumbosacral motoneurones undergoing chromatolysis were studied by intracellular recording from 7 to 20 days after section of the appropriate ventral roots of the cat.2. The maximum monosynaptic EPSPs evoked in chromatolysed motoneurones by afferent volleys from the biceps-semitendinosus or the triceps surae muscles ranged from 1.0 to 9.5 mV in amplitude. The time-to peak of these EPSPs was 1.7 msec on the average. These values were significantly smaller and longer, respectively, than the amplitude and the time-to-peak of monosynaptic EPSPs observed in normal motoneurones. The long time-to-peak of EPSPs in chromatolysed motoneurones could not be accounted for by asynchronous transmitter release.3. The mean number of unit EPSPs responding to a single afferent impulse (m) in chromatolysed motoneurones was comparable to that found in normal motoneurones.4. The amplitude of unit EPSPs estimated from the mean EPSP amplitude and the m value following stimulation of a single afferent fibre was significantly smaller in chromatolysed motoneurones than in normal motoneurones. This difference was attributed to a difference in synaptic location.5. The shape of monosynaptic EPSPs evoked in chromatolysed motoneurones by stimulation of single afferent fibres was analysed on the basis of Rall's compartment model. The analysis suggested that there is a lack of the excitatory synaptic input to the cell body in chromatolysed motoneurones.6. Similar alterations were also found in IPSPs. The degree of change in synaptic responses evoked by stimulation of various pathways appears to depend on the synaptic location.7. Following the study of the interaction of several inputs on the motoneurone and of their dependence on membrane potential, a tentative model of the synaptic distribution of different pathways is proposed. PMID- 4322768 TI - [Functional state of the adrenal cortex in patients with coronary arteriosclerosis]. PMID- 4322769 TI - Besnoitia darlingi in the opossum (Didelphis marsupialis). PMID- 4322770 TI - A new method of housing axolotls and other aquatic amphibians. PMID- 4322771 TI - Primate restraint system for studies of metabolic responses during recumbency. PMID- 4322772 TI - Toxoplasmosis in Aotus trivirgatus and Callicebus moloch. PMID- 4322773 TI - Consumption of oxytetracycline in drinking water by healthy mice. PMID- 4322774 TI - Baseline values for adult baboon cerebrospinal fluid. PMID- 4322775 TI - An epizootic of measles in a marmoset colony. PMID- 4322776 TI - Obesity predisposes to pregnancy toxemia (ketosis) of guinea pigs. PMID- 4322777 TI - The relationship of Pasteurella multocida to otitis media in the domestic rabbit (Oryctolagus cuniculus). PMID- 4322778 TI - Epizootiology and control of salmonellosis in a laboratory aviary. PMID- 4322779 TI - Trichosomoides crassicauda infection of a commercial rat breeding colony. I. Observations on the life cycle and propagation. PMID- 4322780 TI - Modification of the tuberculin response of rhesus monkeys by isoniazid therapy. PMID- 4322781 TI - Cutaneous streptothricosis (dermatophiliasis) in owl monkeys. PMID- 4322782 TI - Carbon dioxide and ammonia in mouse cages: effect of cage covers, population, and activity. PMID- 4322783 TI - An analysis of the crop contents of White Carneaux pigeons (Columba livia), days one through twenty-seven. PMID- 4322784 TI - [3 case reports]. PMID- 4322785 TI - Thyroid tumour scanning with 197HgCl2. Preliminary note. PMID- 4322786 TI - [Use of the Amplipulse-3T apparatus in peripheral nerve diseases accompanied by a pain syndrome]. PMID- 4322787 TI - [Induction of specific antitumor immunity in hamsters using cells infected with adenovirus SA7 (C8)]. PMID- 4322788 TI - [Significance of trace elements in food for phosphorus-calcium metabolism]. PMID- 4322789 TI - [Hemangiopericytoma]. PMID- 4322790 TI - Effect of exogenous adrenocorticotropic hormone on plasma calcium and bicarbonate concentration in domestic fowl. PMID- 4322791 TI - Concurrent infectious mononucleosisand acute leukemia. Case reports. Review of theliterature and serologic studies with the herpes-type virus (EB virus). PMID- 4322792 TI - Pneumocystis carinii. PMID- 4322793 TI - Isolates of members of the Mimeae tribe. PMID- 4322794 TI - Aflatoxins. PMID- 4322795 TI - Experiments with mammalian tumor isolates. PMID- 4322796 TI - Ultraviolet spectrogramic microscope studies of Rous sarcoma virus cultured in cell-free medium. PMID- 4322797 TI - Microorganisma associated with malignancy. PMID- 4322798 TI - Herpesvirus type 2 and cervical carcinoma. PMID- 4322799 TI - Preparation of soluble monoamine oxidase from pig liver mitochondria. PMID- 4322800 TI - Steroid hydroxylations in rat adrenal mitochondria. II. Competition between energy-linked transhydrogenase-dependent steroid hydroxylation and oxidative phosphorylation for high-energy intermediates and NADH. PMID- 4322801 TI - The reduction of ferricytochrome c by pyridine coenzymes mediated by thyroid hormones and related compounds. PMID- 4322802 TI - Further studies on the relationship of the stimulatory effects of phenobarbital and 3,4-benzpyrene on hepatic heme synthesis to their effects on hepatic microsomal drug oxidations. PMID- 4322803 TI - Interaction of cyclic GMP and cyclic AMP with a cyclic nucleotide phosphodiesterase of the frog erythrocyte. PMID- 4322804 TI - Inhibition of mitochondrial swelling by 19-nor-ethynyltestosterone acetate and other steroids. PMID- 4322805 TI - The tryptic digestion of spin-labelled heavy meromyosin. PMID- 4322806 TI - Partial purification and properties of the fructose-1,6-diphosphatase from Acinetobacter lwoffi. PMID- 4322807 TI - Isolation of two small molecular weight RNA components by MAK column chromatography. PMID- 4322808 TI - Biological roles for 3',5'-cyclic nucleotides. I. Lipolytic agents in isolated rat epididymal adipose cells and substrates for adipose tissue phosphodiesterase. PMID- 4322809 TI - Formation of retinoic acid from retinol in the kidney. PMID- 4322810 TI - Regulation of the purine pathway in bakers yeast: activity and feedback inhibition of phosphoribosyl-pyrophosphate amidotransferase. PMID- 4322811 TI - Excitation transfer in complexes of horse liver alcohol dehydrogenase. PMID- 4322812 TI - The influence of membranes on the temperature-induced changes in the kinetics of some respiratory enzymes of mitochondria. PMID- 4322813 TI - Separation of regulatory and catalytic subunits of the cyclic 3',5'-adenosine monophosphate-dependent protein kinase(s) of rabbit skeletal muscle. PMID- 4322814 TI - The role of cyclic AMP in chemotaxis in Escherichia coli. PMID- 4322815 TI - Differences in methionyl- and arginyl-tRNA'S of larval and adult bullfrogs. PMID- 4322816 TI - Synthesis of a copolymer containing adenylic and deoxyadenylic acid residues with polynucleotide phosphorylase. PMID- 4322817 TI - Studies on spin-labeled actin. PMID- 4322818 TI - [Structure and reactivity of steroids. Kinetics of oxidation of estradiol-3,17 beta and its 3-methyl ester by an enzyme preparation from human placena]. PMID- 4322819 TI - Deuterium NMR and EPR of hydrated collagen fibers in the presence of salts. PMID- 4322820 TI - [Bioelectric activity of neurons in the medulla oblongata receiving afferent impulses from the heart]. PMID- 4322821 TI - Factors affecting lecithinase activity and production in Clostridium welchii. PMID- 4322822 TI - Haemolytic activity of the alpha and theta toxins of Clostridium welchii. PMID- 4322823 TI - HI antibody to various influenza viruses and adenoviruses in individuals of blood groups A and O. PMID- 4322824 TI - [Intracranial multiform glioblastomas of a young subject, manifesting themselves originally by a lower radiculospinal compression]. PMID- 4322825 TI - [Cerebral compression from a cylindroma with intracranial development]. PMID- 4322826 TI - Survival of foot-and-mouth disease virus on meat packaging materials. PMID- 4322827 TI - Clinical and serologic response of American white-collared peccaries to African swine fever, foot-and-mouth disease, vesicular stomatitis, vesicular exanthema of Swine, hog cholera, and rinderpest viruses. PMID- 4322828 TI - Studies on acute Marek's disease detection of antibodies with a tannic acid indirect hemagglutination test. PMID- 4322829 TI - The differential diagnosis of Marek's disease and lymphoid leukosis. PMID- 4322830 TI - Field and laboratory studies with Marek's disease. PMID- 4322831 TI - In vitro study of Bovine Virus Diarrhea virus: interactions with some selected viruses. PMID- 4322832 TI - [Feyrter's granular neuroma. Electron-optic study]. PMID- 4322833 TI - [Carrier materials for biologic tests in electron radiation analysis]. PMID- 4322834 TI - Separation of estriol conjugates on Sephadex. PMID- 4322835 TI - Myocardial reactive hyperemia responses in the dog after aminophylline and lidoflazine. PMID- 4322836 TI - Malignant hyperthermia associated with hypocalcemia. PMID- 4322837 TI - [Bronchial carcinoid tumor in a 14-year-old girl]. PMID- 4322839 TI - [Electron microscopic detection of mengovirus in L cells with ferritin-labeled antibodies]. PMID- 4322838 TI - [Stabilization of N-antigens of enteroviruses]. PMID- 4322840 TI - Temperature-dependent interferon-sensitivity of foot-and-mouth disease virus. PMID- 4322841 TI - Interferon induction in hamster embryo cells and newborn hamsters infected with polyoma virus. PMID- 4322843 TI - Studies on inhibition of viral oncogenesis. II. Inhibitory effect of L asparaginase, clam liver extract and methotrexate on rous sarcoma virus focus formation. PMID- 4322842 TI - A survey for human enteroviruses in dogs and man. Enterovirus survey. PMID- 4322844 TI - Immunologic response of lambs to emulsified foot-and-mouth disease vaccine. PMID- 4322845 TI - The occurrence of human influenza virus antibodies in the sera of certain wild species of animal. Brief report. PMID- 4322847 TI - Neurovirulence of polioviruses isolated form sewage and stool of healthy children. II. Neurovirulence of strains and types 1 and 3. PMID- 4322846 TI - Behavior of poliovirus strains of different virulence under solid overlays. PMID- 4322848 TI - Effects of temperature on viral RNA synthesis and RNA polymerase activity in a foot-and-mouth disease virus system. PMID- 4322849 TI - Foot-and-mouth disease virus: rapid assay using the fluorescent antibody technique. PMID- 4322850 TI - Method for the preparation of a herpesvirus hominis fluorescent conjugate for direct immunofluorescence. PMID- 4322851 TI - Herpes simplex virus-induced congenital cataracts. PMID- 4322853 TI - [Presynaptic action of imidazole on frog neuromuscular junction]. PMID- 4322852 TI - [Effect of 8-mercaptoadenine on cellular metabolism]. PMID- 4322854 TI - [Functional state of the adrenal cortex in experimental blood transfusion complications]. PMID- 4322855 TI - Characterization of two ganglion cell populations in avian ciliary ganglia. PMID- 4322856 TI - Effect of ethanol on metabolism and subcellular distribution of serotonin in rat brain. PMID- 4322857 TI - Antigenic properties of the bacteriocine preparations obtained from type A Cl. perfringens strains. PMID- 4322858 TI - A review of the complications of spinal anaesthesia with experiences in Canadian teaching hospitals from 1959 to 1969. PMID- 4322859 TI - Regulation of the lactate metabolism. PMID- 4322860 TI - Characteristics of response of renal vascular bed to contrast media. Evidence for vasoconstriction induced by renin-angiotensin system. PMID- 4322861 TI - Antigenic relationships between cell membranes of normal and SV40 transformed hamster kidney cells. PMID- 4322863 TI - The induction of precipitating antibodies to the mammary tumor virus in several inbred mouse strains. PMID- 4322862 TI - Tumor-specific antigens in 2-acetylaminofluorene-induced rat hepatomas and related tumors. PMID- 4322864 TI - Immunological aspects of the relationship between host and oncogenic virus in the mouse mammary tumor system. PMID- 4322865 TI - Studies on the immunogenicity of preneoplastic and neoplastic mammary tissues of BALB-c mice free of the mammary tumor virus. PMID- 4322866 TI - Mouse mammary tumorigenesis by mammary tumor virus in the absence of thymus, spleen or both organs. PMID- 4322867 TI - Mass spectrometry of nucleic acid components. Trimethylsilyl derivatives of nucleotides. PMID- 4322868 TI - [Diffuse cerebral fat embolism: complication of lipiodol lymphography]. PMID- 4322869 TI - Factors affecting the sensitivity of different viruses to interferon. AB - When the sensitivities to interferon of Newcastle disease virus (NDV) and vesicular stomatitis virus (VSV) were compared by the plaque reduction method in chick embryo cell cultures, NDV was found to be 45-fold more resistant than VSV. This difference was exaggerated when a multiple-cycle yield inhibition method was employed. In marked contrast, when the same viruses were tested by a single-cycle yield inhibition method, the difference in sensitivity to interferon of the two viruses was virtually eliminated. Further investigation showed that, in chick embryo cells exposed to interferon, the resistance to NDV decayed more rapidly than resistance to VSV. This finding explained the divergent results obtained with the two viruses when single- or multiple-cycle replication techniques were employed. Experiments carried out with L cells showed that cellular antiviral resistance decayed much more slowly in these cells than in chick embryo cells. Consequently, when measured by the plaque reduction method in L cells, no difference was observed in the sensitivity to interferon of VSV and NDV(pi), a mutant of NDV which replicates efficiently in L cells. A procedure is suggested for determining the relative sensitivities to interferon of different viruses under conditions which minimize the role of decay of antiviral resistance in the host cells. PMID- 4322870 TI - Comparison of membrane protein glycopeptides of Sindbis virus and vesicular stomatitis virus. AB - A comparison has been made of the membrane glycoproteins and glycopeptides from two enveloped viruses, Sindbis virus and vesicular stomatitis virus (VSV). Glycopeptides isolated from Sindbis virus and VSV grown in the same host appear to differ principally in the number of sialic acid residues per glycopeptide; when sialic acid is removed by mild acid treatment, the glycopeptides of the two viral proteins are indistinguishable by exclusion chromatography. Preliminary evidence argues that the carbohydrate moiety covalently bound to different virus specified membrane proteins may be specified principally by the host. PMID- 4322871 TI - Characterization of some poliovirus temperature-sensitive mutants and poliovirus related particle formation under nonpermissive conditions. AB - Investigation of 15 poliovirus temperature-sensitive (ts) mutants by using physiological tests [formation of virus-specific antigen and ribonucleic acid (RNA) under nonpermissive conditions] permitted us to divide them into three groups. From each group, one mutant was selected (ts 2, 5, 11), and a comparative study of poliovirus-related particle (5, 10, 73, and 150S) formation under permissive (36 C) and nonpermissive (40 C) conditions was carried out. The ts 2 and ts 11 are mutants with greatly reduced RNA synthesis which at 40 C produce particles with a sedimentation constant of 5S, and the ts 5 (RNA(+)) mutant produces both 5 and 10S particles. The relationship between different temperature sensitive defects in the mutants is discussed. The results obtained indicate a possible role of 5S protein structures in morphogenesis of poliovirus. PMID- 4322873 TI - Induction of mitochondrial DNA synthesis by polyoma virus. PMID- 4322872 TI - Virus-specific deoxyribonucleic acid in simian virus 40-exposed hamster cells: correlation with S and T antigens. AB - Several homologous hamster embryonic cell lines, transformed in association with simian virus (SV) 40 infection, were examined for the presence of deoxyribonucleic acid (DNA) complementary to SV40 ribonucleic acid (RNA) made in vitro. The methods employed permitted the detection of 10(-5) mug of viral DNA in 100 mug of cellular DNA, corresponding to one-fifth of an SV40 DNA molecule per cell. Those lines which contained both the SV40 surface (S) and tumor (T) antigens also contained DNA complementary to SV40 RNA synthesized in vitro. In contrast, neither of two lines which contained S, but not T, antigen contained detectable DNA complementary to SV40 RNA. These findings suggest that the production of S antigen does not depend upon the persistence of SV40 DNA in transformed cells. PMID- 4322874 TI - Strains of bovine enterovirus sharing antigen with polio virus-2. PMID- 4322875 TI - Induction of acetylcholinesterase activity in mouse neuroblastoma tissue culture cells. PMID- 4322876 TI - [Catamnestic studies of the results of rehabilitation of patients with multiple sclerosis]. PMID- 4322877 TI - [Paroxysmal ataxia, tonic spasms and paroxysmal paralysis in multiple sclerosis]. PMID- 4322878 TI - [Technic of cerebral contrast studies in stereoelectroencephalography]. PMID- 4322879 TI - [Application of the Polish-built computer Anops for the recording of histogram of muscle action potentials' duration]. PMID- 4322880 TI - [Trial therapy of reticulosis X]. PMID- 4322881 TI - [Clinical and roentgenologic characteristics of pulmonary adenomas]. PMID- 4322882 TI - [A study of the antigenic structure of human sarcoma by the agar precipitation method]. PMID- 4322883 TI - [Antigenic simplification of rat liver tissue during hepatocarcinogenesis]. PMID- 4322884 TI - [Diagnosis of malignant synoviomas]. PMID- 4322885 TI - A histochemical survey of the glucose-6-phosphate hydrolysing enzyme activity in the RES: a light microscopic study. PMID- 4322886 TI - [Protein and sulfated mucopolysaccharide in the botryoid granules of the horse leech (Haemopsis sanguisuga L)]. PMID- 4322887 TI - [Histochemical demonstration of pyridine nucleotide-dependent dehydrogenases; a semiquantitative study]. PMID- 4322888 TI - The effect of ACTH and cortisone on behaviour of arylsulphatase in intestine mucosa of white rat. PMID- 4322889 TI - [Topochemistry of detoxication metabolism by glucuronidation. I. Demonstration of uridinediphosphate glucose dehydrogenase in liver and kidney of different species by means of an improved gel incubation method]. PMID- 4322891 TI - Herpes simplex infection complicating Darier's disease. Caused by type 1 herpesvirus hominis. PMID- 4322890 TI - Infection and nutrition of children of a low socioeconomic rural community. PMID- 4322892 TI - Subungual glomus tumor. Radiological manifestations. PMID- 4322893 TI - Nature of rat liver cell sap factors inhibiting the DNA synthesis in tumour cells. PMID- 4322894 TI - [Use of delayed-action Cortrosyn (Tetracosactide) in rheumatology. Apropos of 32 cases]. PMID- 4322895 TI - Report on an epizootic of Marek's disease in South Vietnam. PMID- 4322896 TI - Avian leukosis complex in Japan. PMID- 4322897 TI - Avian leucosis & Marek's disease in Australia. PMID- 4322898 TI - What signals the kidney to release renin? PMID- 4322899 TI - Autonomic control of cardiac C-AMP. PMID- 4322900 TI - Disseminated intravascular coagulation in newborns. Survey and appraisal as exemplified in two case histories. PMID- 4322901 TI - RISA brain scans in chilren. Movement of radioactive albumin in cerebrospinal fluid aids recognition of disturbances in flow. PMID- 4322902 TI - [Association of hypoglycemia due to an islet cell adenoma and hyperparathyroidism due to glandular hyperplasia]. PMID- 4322903 TI - Action of testosterone on nucleic acids of rat liver subcellular fractions. PMID- 4322905 TI - ESR study of the sugar radical in irradiated deoxyadenosine. PMID- 4322904 TI - The lysine catalysed reaction transforming glyceraldehyde into methylglyoxal. PMID- 4322906 TI - Prejunctional effect of curare: its relative importance. PMID- 4322909 TI - [Case of malignant granular cell tumor]. PMID- 4322911 TI - Pituitary apoplexy. PMID- 4322912 TI - Malignant melanoma presenting with bone metastasis and food drop. PMID- 4322913 TI - Pathology mediquiz. Case 3. PMID- 4322910 TI - [Erythropoietin, renin, aldosterone, and blood volume in primary and secondary polycythemia]. PMID- 4322914 TI - Mixed mesodermal tumors. Report of a case. PMID- 4322915 TI - [On the reconstruction of the digestive tract after total gastrectomy. Technical aspects and physiopathologic evaluations on esophago-duodenostomy]. PMID- 4322916 TI - Mossy and climbing fiber activity during phasic and tonic phenomena of sleep. PMID- 4322917 TI - Modulation of sensory transmission in cat lemniscal system during voluntary movement. PMID- 4322918 TI - Influence of ethanol on carbohydrate metabolism. A review. PMID- 4322919 TI - Feminizing mesenchymal tumours of the ovary. A clinico-pathological review. PMID- 4322920 TI - [Apropos of 2 cases of insulinoma. Note on the effect of hypoglycemic effect of leucine]. PMID- 4322921 TI - [Diagnosis and treatment of pancreatic insulin-secreting tumors. Apropos of 2 cases observed personally]. PMID- 4322922 TI - Endocrine hyperfunction amenable to surgery: selected aspects of diagnosis and postoperative treatment. PMID- 4322923 TI - Mediastinal tumors and cysts. PMID- 4322924 TI - [Coronary diseases observed in Abidjan in African Negroes]. PMID- 4322925 TI - [Changes induced by hydrocorticoids in the responses to norepinephrine and to (dibutyrryl) cyclic 3,5 AMP in the hearts of normal and perfused adrenalectomized animals]. PMID- 4322926 TI - [Orthodromic transmission of vestibular impulses through Deiter's nucleus during sleep and wakefulness]. PMID- 4322927 TI - [Addison's disease and problems in hormone therapy--skin pigmentation and hormone therapy]. PMID- 4322928 TI - [Practical value of the determination of plasma renin activity in the study of arterial hypertension]. PMID- 4322930 TI - The antibody response in newborn precolostral germfree piglets following the peroral monocontamination with attenuated Teschen disease virus (TDV). PMID- 4322929 TI - Role of endogenous tryptophan during submerged fermentation of ergot alkaloids. PMID- 4322931 TI - [Phyllodes tumors of the breast. 6 cases. Review of the literature]. PMID- 4322932 TI - Effect of adenovirus type 12 on tumor induction by SV40 and para (defective SV40). PMID- 4322933 TI - [Invstigation of the presence of viral particles in Rous virus transformed hamster cell lines]. PMID- 4322934 TI - Mammary tumors, plaques, and hyperplastic alveolar nodules in various combinations of mouse inbred strains and the different lines of the mammary tumor virus. PMID- 4322935 TI - Distribution of intracisternal A-particles in a variety of normal and neoplastic mouse tissues. PMID- 4322936 TI - Demonstration by colony inhibition methods of cellular and humoral immune reactions to tumour-specific antigens associated with aminoazo-dye-induced rat hepatomas. PMID- 4322937 TI - Demonstration of cell-mediated immunity to human neoplasms of various histological types. PMID- 4322938 TI - Differences in the manifestation of virus-specific surface antigen between cells transformed by SV40 and UV-irradiated SV40. PMID- 4322939 TI - Properties of transformed hamster cells containing SV40 tumor antigen in the cytoplasm. PMID- 4322940 TI - Studies on the mechanisms of invasion in cancer. II. In vivo effects of a factor chemotactic for cancer cells. PMID- 4322941 TI - Stimulation by epinephrine of adenyl cyclase activity, cyclic AMP formation, DNA synthesis and cell proliferation in populations of rat thymic lymphocytes. PMID- 4322942 TI - Human-mouse hybrid cell lines and susceptibility to species-specific viruses. PMID- 4322943 TI - Studies on the mechanism of hrmonal stimulation of zinc uptake in human cell cultures: hormone-cell interactions and characteristics of zinc accumulation. PMID- 4322944 TI - DNA replication patterns in chromosomes of several transplantable ascites hepatomas of the rat. PMID- 4322945 TI - The causes of neonatal mortality: an analysis of 501 autopsies on newborn infants. PMID- 4322946 TI - Congenital cytomegalovirus infection in two siblings from consecutive pregnancies. PMID- 4322947 TI - Respiratory tract excretion of cytomegalovirus in Thai children. PMID- 4322948 TI - [Lipiodol umbilico-portography]. PMID- 4322949 TI - Hemolysis and related enzymes of Vibrio parahaemolyticus. PMID- 4322951 TI - Ultrasonic visualization of the breast. PMID- 4322950 TI - Hemorrhagic necrosis in the bone marrow caused by endotoxin injection. PMID- 4322952 TI - [Real tumor in Recklinghausen's disease. Surgical repair by superimposed skin flaps]. PMID- 4322954 TI - Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 13-1971. PMID- 4322953 TI - Natriuretic effect of calcitonin in man. PMID- 4322955 TI - [Clear-cell sarcoma of the tendons and aponeurosis. Diagnostic and therapeutic problems. Apropos of a case]. PMID- 4322956 TI - [Primary cancer of the liver superimposed upon cirrhosis]. PMID- 4322958 TI - Retrograde amnesia: electroconvulsive shock effects after termination of rapid eye movement sleep deprivation. AB - Mice that were deprived of rapid eye movement sleep for 2 days immediately after one-trial training in an inhibitory avoidance task and were given an electroconvulsive shock after deprivation displayed retrograde amnesia on a retention test given 24 hours later. Electroconvulsive shock produced no amnesia in comparable groups of animals that were not deprived of rapid eye movement sleep. PMID- 4322957 TI - [Biochemical, morphological and functional disorders of the higher nerve centers in rabbits with experimental periodontosis, induced by irritation of the dental pulp with tricresol-formalin and eugenol]. PMID- 4322959 TI - [Infringement on methodical conditions of comparability by some radiographic data on bone age]. PMID- 4322960 TI - [Transplantable strain of rat hepatoma G-27]. PMID- 4322961 TI - [Arteriography in tumorous diseases of the liver]. PMID- 4322962 TI - [Skin neoplasms]. PMID- 4322963 TI - Otosclerosis. An electron microscopic and cytochemical study. PMID- 4322964 TI - Clinical photocoagulation with the frequency-doubled neodymium yttrium-aluminum garnet laser. PMID- 4322965 TI - Hepatic lobectomy. PMID- 4322966 TI - Lipomas of the upper extremity. A series of fifteen tumors in the hand and wrist and six tumors causing nerve compression. PMID- 4322967 TI - Entrapment of the ulnar nerve at the elbow. PMID- 4322968 TI - Regulation of extracellular cyclic-AMP-phosphodiesterase activity during development of Dictyostelium discoideum. PMID- 4322969 TI - Oxygenated cytochrome P-450 and its possible role in enzymic hydroxylation. PMID- 4322970 TI - Catabolite repression of chloramphenicol acetyl transferase synthesis in E. coli K12. PMID- 4322971 TI - E.P.R. evidence for the linking of copper(II) ions by hypoxanthine and by 4 azabenzimidazole. PMID- 4322972 TI - Effects of chemical disruption on the biological activities of sea urchin egg jelly. PMID- 4322973 TI - Separation of various blood cells in colloidal silica-polyvinylpyrrolidone gradients. PMID- 4322974 TI - Entamoeba histolytica: aldolase and alpha-amylase in rats treated with emetine and enterovioform. PMID- 4322975 TI - Cytochemical and biochemical observations on the digestive tracts of digenetic trematodes. V. Ultrastructure of Schistosomatium douthitti gut. PMID- 4322976 TI - Skeletal maturation studied longitudinally over one year in American Whites and Negroes six though thirteen years of age. PMID- 4322977 TI - Effect of hormonal treatments in rats on the intestinal transport of methionine in vitro. PMID- 4322978 TI - Phosphatase activity in marine environments: open sandy beach at Porto Novo. PMID- 4322979 TI - Comparative aspects of Poliovirus replication. PMID- 4322980 TI - SDS-acrylamide gel electrophoresis and its application to the proteins of poliovirus- and adenovirus-infected human cells. PMID- 4322981 TI - Responsiveness of normal and transformed rat embryo cell cultures to poly I-poly C and interferon. PMID- 4322982 TI - [Age determination by skeleton]. PMID- 4322983 TI - [Value of arteriography in sub-ungual glomus tumors]. PMID- 4322984 TI - [A method for the measurement of plasma renin activity. I]. PMID- 4322985 TI - [Importance of the Au hepatitis antigen in the diagnosis of viral hepatitis]. PMID- 4322986 TI - [Plasmatic and erythrocytic angiotensinase in the different trimesters of normal pregnancy]. PMID- 4322987 TI - [On the action of different concentrations of urea on human erythrocytic angiotensinase activity in vitro]. PMID- 4322988 TI - An epidemic of adenovirus type-7 bronchopneumonia in Bantu children. PMID- 4322989 TI - Clinical experience with ibuprofen in rheumatoid arthritis. PMID- 4322990 TI - The conjugated estrogens. I. A new fractionation procedure suitable for large volumes of urine. A. Normal pregnancy urine. PMID- 4322991 TI - The DNA content of alveolar macrophages and a so-called alveolar cell carcinoma. PMID- 4322992 TI - Chromosomal characteristics of neurogenic tumors in children. PMID- 4322993 TI - Cellular changes of normal human cervical epithelium infected in vitro with Herpesvirus hominis, type two (Herpes simplex). PMID- 4322994 TI - Evidence for an immunological factor in the hypertensive vascular disease. PMID- 4322995 TI - The site and mode of action of propanidid on the peripheral motor unit. PMID- 4322996 TI - Neural control of mechanical and electrical properties in slow muscle fibres of the frog. PMID- 4322997 TI - [Pathophysiology of myasthenia gravis and the myasthenic syndrome]. PMID- 4322998 TI - Presynaptic aspects of neuromuscular transmission and block. PMID- 4322999 TI - Biochemistry and function of biogenic amines in the central nervous system. PMID- 4323000 TI - [Indirect fluorescent antibody technic with substrate absorbed serums and conjugates]. PMID- 4323001 TI - Fanconi anemia syndrome. PMID- 4323003 TI - The uptake of SV40 DNA by nonpermissive cells in the presence of DEAE-dextran. PMID- 4323004 TI - Peptidyl-tRNA. XII. Behaviour of peptidyl-tRNA-Phe from Escherichia coli on methylated albumin silicic acid column. PMID- 4323006 TI - Sinapic acid and methyl sinapate in rapeseed lipids. PMID- 4323005 TI - Purification and some properties of an acid deoxyribonuclease from testes of chinook salmon Oncorhynchus tshawytscha. PMID- 4323007 TI - The extraction of acidic phospholipids in organic solvent mixtures containing water. PMID- 4323008 TI - Hepatic sulfation of estrogen metabolites. PMID- 4323009 TI - Intramitochondrial localization of palmityl-CoA dehydrogenase, beta-hydroxyacyl CoA dehydrogenase and enoyl-CoA hydratase in guinea-pig heart. PMID- 4323010 TI - Existence of ceramide in alfalfa leaves. PMID- 4323011 TI - Palmitoyl-CoA synthetase activity in isolated rat epididymal fat cells in the absence and presence of various lipolytic and anti-lipolytic compounds. PMID- 4323012 TI - [Angioarchitecture in brain tumor; relationship between cerebral angiograms and clinical courses]. PMID- 4323013 TI - [Mitochondrial DNA of malignant cells]. PMID- 4323014 TI - [Transformation and differentiation of renal tissue by an oncogenic RNA virus]. PMID- 4323015 TI - Activation of sodium transport across biological membranes. PMID- 4323016 TI - Circadian rhythm in adrenal adenyl cyclase and corticosterone abolished by medial forebrain bundle transection in the rat. PMID- 4323017 TI - Stimulation of RNA polymerase activity by histones, polyamino acids, and polypeptide hormones. PMID- 4323018 TI - Pharmacological effects of carbaryl. II. Modification of serotonin metabolism in the rat brain. PMID- 4323019 TI - [Influencing of microsomal enzymes by carbon tetrachloride with and without phenobarbital pretreatment]. PMID- 4323020 TI - Enhancing effect of Bordetella pertussis and propranolol on experimental immune hemolytic anemia. PMID- 4323022 TI - Theory of flicker and transient responses. I. Uniform fields. PMID- 4323023 TI - Ultrastructural changes produced by glucagon, cyclic 3'5'-AMP and epinephrine on perfused rat livers. PMID- 4323024 TI - The ultrastructure of the reovirus inclusion: a freeze etching study. PMID- 4323025 TI - Intraepithelial cells in the human intestinal mucosa. PMID- 4323026 TI - Cytoplasmic bodies with a crystalline substructure in the follicular cells of the mouse thyroid gland. PMID- 4323027 TI - [Clinical testing of iruxol ointment]. PMID- 4323028 TI - [Current status of treatment with a synthetic corticotropic peptide, tetracosactide-retard]. PMID- 4323029 TI - [Herpesvirus meningoencephalitis]. PMID- 4323030 TI - [Disseminated intravascular coagulation]. PMID- 4323031 TI - [Medullary arteriovenous aneurysms]. PMID- 4323032 TI - [Mesothelial cell effusions. Anatomo-cytological comparison]. PMID- 4323033 TI - [Acute ethylene glycol poisoning. Apropos of a case]. PMID- 4323034 TI - [What errors should be avoided in the treatment of asthma?]. PMID- 4323035 TI - [Treatment of mixed tumors of the salivary glands]. PMID- 4323036 TI - [Primary cancer of the liver]. PMID- 4323037 TI - [Benign esophageal neoplasms]. PMID- 4323038 TI - [Clinical studies and diagnosis of changes in fundus oculi in cytomegalic inclusion disease]. PMID- 4323039 TI - [Angiographic diagnosis of abdominal masses in children suspected of renal and retroperitoneal malignancy]. PMID- 4323040 TI - [Skeletal metastases in Wilms' tumour: a roentgenologic study]. PMID- 4323041 TI - [ESR and CD spectra of the pH-dependent conformation isomers of hemoglobin (3)]. PMID- 4323042 TI - [Demonstration of conformation isomers of hemoglobin (3) of Chironomus th. thummi by electron spin resonance]. PMID- 4323043 TI - Oxygen-17 hyperfine splitting in the electron paramagnetic resonance spectrum of enzymically generated superoxide. PMID- 4323044 TI - [Relation of peak activity and electrocorticogram in a neuronally-isolated cortex]. PMID- 4323045 TI - [Role of intracortical connections in the development of desynchronization reactions in the basic rhythms of the electrocorticogram]. PMID- 4323046 TI - [Cortical regulation of internal organ functions]. PMID- 4323047 TI - [Functional organization of the visual analyzer of the tortoise]. PMID- 4323048 TI - [Influence of adrenalectomy on monoamine oxidase activity and serotonin content in the brain of rats--on the effects of formalin, ACTH and cortisone]. PMID- 4323049 TI - [Immunization against nucleic acids and interferon production. Preliminary studies]. PMID- 4323050 TI - [Sensitivity of certain biotypes of B. abortus and B. melitensis to 3 antibiotics]. PMID- 4323052 TI - [On the behavior in sea water of various strains of virulent and attenuated polioviruses]. PMID- 4323053 TI - [Clinical studies on serum leucyl glycyl glycine hydrolyzing enzyme in cancer. I]. PMID- 4323051 TI - [New findings on Entamoeba histolytica]. PMID- 4323054 TI - [Etiology of air way infections in general practice]. PMID- 4323055 TI - The high voltage immunoelectroosmophoretic (IEOP) technique for detection of SH antigen: application to blood donor screening and to study of liver disease. PMID- 4323056 TI - Transmission of viral hepatitis to nonhuman primates. PMID- 4323057 TI - Failure to detect Australia antigen in correspondence to other clinical, epidemiological and laboratory data in children with infectious hepatitis. PMID- 4323059 TI - Congenital cytomegalic inclusion disease. PMID- 4323058 TI - Changes in cell population and intercellular relationships in the course of an "in vitro" initiated secondary immune response to poliovirus. PMID- 4323060 TI - [Double infection with fatal outcome due to cytomegalovirus and adenovirus type 3 in a premature infant]. PMID- 4323061 TI - [Bone lesions in solitary glomus tumors in children]. PMID- 4323062 TI - Concentration of homovanillic acid and 5-hydroxyindoleacetic acid in the cerebrospinal fluid after treatment with probenecid in patients with drug-induced tardive dyskinesia. PMID- 4323064 TI - [Inhibition of the mitotic activity of human leukocytes in vitro by 3'-5'-AMP]. PMID- 4323063 TI - [Experimental cerebral tumors induced by azo compounds]. PMID- 4323065 TI - [Glucose-6-phosphatase acitvity in the hepatocytes and interrenal cells of Salamandra salamandra L. (Amphibia urodele). Ultrastructural localization]. PMID- 4323066 TI - [Phenomena of temporal facilitation observed at the level of synapses of static fusimotor fibers in the cat]. PMID- 4323067 TI - [Ultrastructural arguments in favour of the existence of corticotropic cells (ACTH) in the pars intermedia and pars tuberalis of the rat pituitary]. PMID- 4323068 TI - Interstitial radioisotope therapy of intractable diencephalic tumors by the stereotaxic permanent implantation of iridium192, including bioptic control. PMID- 4323069 TI - [Improvement of panmyelography with a contrast media emulsion. (Preliminary report)]. PMID- 4323070 TI - On the number and nature of antigen-sensitive lymphocytes in the blood of delayed hypersensitive human donors. AB - The virus plaque assay has been successfully employed to enumerate antigen sensitive cells in the peripheral blood lymphocyte populations of tuberculin hypersensitive human donors. The method is based on the finding that, while resting lymphocytes are unable to produce a variety of viruses upon infection, lymphocytes activated by specific antigens become capable of virus replication. The average number of antigen-sensitive cells detected in cell populations from donors reacting to first test strength or intermediate test strength tuberculin was approximately 3.6/1000 lymphocytes, and the averages for both groups were similar. Studies on the kinetics of appearance of these virus plaque-forming cells and on the effects of the mitotic inhibitor, vinblastine, indicate that the activation of these antigen-sensitive cells is a linear process and that the cells must be nondividing cells during this process. These qualities contrast markedly with those described for the mitogenic response and the antibody producing cells which require cell division and increase exponentially. On the basis of these experiments it is suggested that the antigen-sensitive cell measured in the virus plaque assay is the effector cell in delayed-type hypersensitivity reactions and, in addition, may be one of the cells critically involved in antibody formation. PMID- 4323071 TI - Macrophage plasma membranes. I. Isolation and studies on protein components. AB - Plasma membranes have been isolated from pure populations of rabbit alveolar macrophages which were swollen in water, fixed briefly with glutaraldehyde, disrupted by Dounce homogenization, and separated by sucrose gradient centrifugation. The recovered membranes exhibited good structural preservation and enzymatic activity; both morphologic and biochemical evidence indicated a high degree of purity (>90%) of the membrane preparation. Interiorized plasma membranes were also prepared without exposure to glutaraldehyde from phagocytic vacuoles recovered from alveolar macrophages which had ingested large numbers of polystyrene spheres. These membranes were contaminated with lysosomal constituents, but they were nevertheless of value for comparison to the "pure" membranes isolated by the glutaraldehyde procedure. Acrylamide gel electrophoresis of the solubilized plasma membranes and phagolysosomal membranes revealed similar protein patterns, with seven to nine individual components ranging in molecular weight from 70,000 to 140,000. The two most rapidly migrating components gave positive reactions for lipid as well as protein. A band containing carbohydrate was detected near the origin of the plasma membrane gels. Antisera were made by injecting guinea pigs with the purified rabbit alveolar macrophage plasma membranes. Gel diffusion and immunoelectrophoretic study of these antisera established the presence of rabbit immunoglobulin G and of one or two other antigenic constituents in the membrane preparation. PMID- 4323072 TI - A problem in management. PMID- 4323073 TI - [Small Wilms' tumor manifesting a kidney pelvis rhabdomyosarcomatous component. Nephrectomy. Low secondary ureteral localization. Reintervention. 2-year remission]. PMID- 4323074 TI - [Spontaneous hematoma of the renal bed, manifesting as Bourneville tuberous sclerosis (disseminated angiomyolipomatosis)]. PMID- 4323075 TI - [Clinical trials of local broad-spectrum antibiotherapy in geriatrics]. PMID- 4323076 TI - [Diagnosis and treatment of hydrocyanic poisoning]. PMID- 4323077 TI - [Treatment of systemic lupus erythematosus with immunosupressive agents. Results of our experience and review of the literature]. PMID- 4323078 TI - [Controlled trial of sulpiride in psychiatry]. PMID- 4323079 TI - [Current status of intestinal tuberculosis. Apropos of 19 cases]. PMID- 4323080 TI - [Dietetics of amino acid metabolism disorders]. PMID- 4323081 TI - Hormone-mediated changes of liver polyribosomes in irradiated rats. PMID- 4323082 TI - [Studies on the metabolism of nicotinamide coenzymes after whole body irradiation. 3. Synthesis of NAD and its precursors in isolated perfused liver]. PMID- 4323083 TI - [Thermographic investigation in the study of superficial and semi-superficial neoplastic processes]. PMID- 4323084 TI - Corticotrophin releasing activity of bradykinin in the rat. PMID- 4323085 TI - Transfer of material between adjacent cells. PMID- 4323086 TI - Treatment of drug addicts. PMID- 4323087 TI - Psychiatric epidemiology and drug addiction among young people. PMID- 4323089 TI - [Experimental study of liver cancer promoted by cortisone. Practical implication]. PMID- 4323088 TI - Effect on sleep of a sleep period time displacement. PMID- 4323090 TI - [Variations in the concentration of substrates and cofactors in the rat liver for the period of a year]. PMID- 4323091 TI - Marek's disease herpesvirus: comparison of foci (macro) in infected duck embryo fibroblasts under agar medium with foci (micro) in chicken cells. PMID- 4323092 TI - Histologic and microbiologic studies of chickens with transient paralysis. PMID- 4323094 TI - Virological investigations of chickens with spontaneous autoimmune thyroiditis. II. Examination of tissues by electron microscopy. PMID- 4323093 TI - Virological investigations of chickens with spontaneous autoimmune thyroiditis. I. Isolation and transmission studies. PMID- 4323095 TI - Experimental dual infections of chickens with infectious bursal and Marek's disease agents. I. Preliminary observation on the effect of infectious bursal agent on Marek's disease. PMID- 4323096 TI - Immunologic and serologic response of White Pekin ducklings inoculated with single and combined duck virus hepatitis and duck virus enteritis modified-live virus vaccines. PMID- 4323097 TI - The NP activation test for assay of avian leukosis-sarcoma viruses. PMID- 4323098 TI - Evidence against embryo transmission of Marek's disease virus. PMID- 4323099 TI - Detection of fowlpox virus antigen in tissue culture by fluorescent antibody technique. PMID- 4323100 TI - Methods in Marek's disease research. PMID- 4323101 TI - [Effect of the stimulation of the gastric acid secretion on the histoenzymology of the gastric mucosa in rats]. PMID- 4323102 TI - Suppression of paradoxical sleep (PS) following hypothalamic defence reactions in cats during normal conditions and recovery from PS deprivation. PMID- 4323103 TI - Facilitation of the direct cortical response of the visual cortex in association with rapid eye movement during paradoxical sleep in the cat. PMID- 4323104 TI - Nucleic acids in fractions isolated from vegetative cells of Cl. perfringens type A. PMID- 4323105 TI - [Identification of the types of foot-and-mouth disease virus]. PMID- 4323106 TI - [Characteristics of immunity against foot-and-mouth disease in vaccinated sheep]. PMID- 4323107 TI - [Measurement of immunity of cattle against foot-and-mouth disease with the use of the sheep test]. PMID- 4323108 TI - [Foot-and-mouth disease of sheep]. PMID- 4323109 TI - [Identification of the types of foot-and-mouth disease virus]. PMID- 4323110 TI - [Identification of the types of foot-and-mouth disease virus. Nong-Sarai (Thailand)]. PMID- 4323111 TI - Carcinogenic effects of cycasin in Syrian golden hamsters and the transplantability of induced tumors. PMID- 4323112 TI - Cytogenetic studies of EB virus-positive and EB virus-negative lymphoblastoid cell lines. PMID- 4323113 TI - [Systematic follow-up study on the circulation of poliomyelitic and other enteral viruses in waste water]. PMID- 4323114 TI - [Importance of renal angiography in Wilms renal tumor]. PMID- 4323115 TI - Corticosteroidogenesis in isolated adrenal cells of rats. I. Effect of corticotropins and 3',5'-cyclic nucleotides on corticosterone production. PMID- 4323117 TI - KI and imidazole inhibition of TSH and c-AMP induced thyroidal iodine secretion. PMID- 4323118 TI - Corticotropin and vasopressin secretion after hypothalamic implantation of atropine. PMID- 4323119 TI - Modification by cortisone of the plasma Ca and P responses to imidazole and theophylline. PMID- 4323116 TI - Nicotinamide HCl and thyroid radioiodine metabolism in mice: effects due to acid. PMID- 4323120 TI - Effects of food deprivation on sleep and wakefulness in the rat. PMID- 4323121 TI - Nonuniform transmission and directional preference in the spread of surface positive burst responses in cerebral cortex: evidence for ordered groups of neurons in the cerebral cortex. PMID- 4323122 TI - The effect of iron deficiency on the tissues. PMID- 4323123 TI - Levels of N-acetylglucosaminides and sulfo-N-acetylglucosaminides of 15-alpha hydroxyestrone and 15-alpha-hydroxyestradiol in human late pregnancy urine. PMID- 4323124 TI - Effect of angiotensin II on adrenal and pituitary function in man. PMID- 4323125 TI - The effect of the heptapeptide (2-8) and hexapeptide (3-8) fragments of angiotensin II on aldosterone secretion. PMID- 4323127 TI - Circulating insulin: th proinsulin-like properties of "big" insulin in patients withou islet cell tumors. AB - When plasma is filtered on Sephadex G-50, insulin immunoreactivity is recovered in two peaks. "Big" insulin, the higher molecular weight component, and "little" insulin, the lower molecular weight component, have elution volumes that correspond to those of proinsulin-(125)I and insulin-(125)I respectively. When plasma was extracted with acid ethanol and filtered in 1.0 M acetic acid, the patterns and proportions of "big" and "little" insulin were indistinguishable from those obtained by filtration of whole plasma in neutral buffer. When "big" insulin was isolated from plasma and mixed with a tracer of porcine proinsulin (125)I, trypsin converted the "big" insulin immunoreactivity to the gel filtration pattern of "little" insulin in the same way that it converted the proinsulin radioactivity. More than 90% of both "big" insulin and proinsulin were converted at optimal trypsin concentrations. Our present guinea pig anti-insulin serum failed to distinguish "big" from "little" but a porcine proinsulin anti serum, under appropriate conditions of assay, reacted strongly with "big" insulin but not at all with "little." When tested on isolated fat cells, "little" insulin had the same bioactivity as porcine insulin, whereas "big" insulin had the same low activity as porcine proinsulin. These studies suggest that "big" insulin represents either single-chain proinsulin and/or a proinsulin intermediate that has similar low bioactivity. PMID- 4323126 TI - Quantification of human platelet inositides and the influence of ionic environment on their incorporation of orthophosphate-32P. AB - Platelets are a rich source for the study of inositol lipids in man. The substitution of an EDTA-KCl solution for the water component of the Bligh and Dyer procedure permitted quantitative extraction of polyphosphoinositides. The latter, with monophosphoinositide, were found to comprise, on a molar basis, 6.7% of total platelet phospholipids. Study of the incorporation of orthophosphate (32)P into platelet phospholipids was further simplified by separating eight (32)P-labeled lipids, including the inositides, with a single chromatographic development on formaldehyde-treated paper. Particular attention was paid to the influence of ionic environment on the pattern and degree of labeling. In 300 mOsm media major phospholipids other than the inositides were not labeled. Small amounts of label appeared in certain trace phospholipids, notably phosphatidic acid. In 150 mOsm media, labeling of inositides was moderately increased, that of trace phospholipids enormously so. The increased labeling was not solely due to thrombocytolysis since (a) platelet disruption by sonication or freeze-thawing abolished (32)P incorporation into phospholipids and (b) in timed studies, restoration of osmolarity to 300 mOsm by addition of hypertonic sorbitol blunted the enhancement effect of previous 150 mOsm exposure. Lowering K and compensatorily increasing Na concentration of 300 mOsm media also stimulated (32)P labeling of inositides and, to a lesser extent, the trace phospholipids. However, the pattern and degree of stimulation were not as strikingly altered as in the osmolarity studies. These data show that drastic alterations of ionic environment can sharply influence the platelet's ability to incorporate orthophosphate-(32)P into its phospholipids. PMID- 4323129 TI - Immunochemical studies of foot-and-mouh disease. IX. Differences in neutralizing activities of guinea pig and bovine 19S and 7S antibodies. PMID- 4323128 TI - Cyclic 3',5'-adenosine monophosphate in the human lukocyte: synthesis, degradation, andeffects n neutrophil candidacidal activity. AB - Prostaglandins E(1) and E(2) (PGE(1) and PGE(2)) stimulate adenyl cyclase activity in broken cell preparations of normal human leukocytes, whereas prostaglandin F(1a) produces no effect. PGE(1) and PGE(2) also cause increased accumulation of cyclic 3',5'-adenosine monophosphate-(3)H ((3)H-labeled AMP) in intact leukocytes which have been preincubated with adenine-(3)H in vitro. Theophylline inhibits leukocyte phosphodiesterase activity and potentiates the stimulatory effect of the prostaglandins on intracellular accumulation of cyclic 3',5'-AMP-(3)H. The ability of human granulocytes in vitro to kill Candida albicans was consistently inhibited by PGE(1) and theophylline. This effect was reproduced by dibutyryl cyclic 3',5'-AMP, a lipid-soluble analogue of the endogenous nucleotide. The inhibition of candidacidal activity could not be accounted for by drug effects on phagocytosis, oxygen consumption, or hexose monophosphate shunt activity. These results are consistent with the hypothesis that increased intracellular concentrations of cyclic 3',5'-AMP impair the granulocyte's ability to kill C. albicans, but the precise mechanism of inhibition has not yet been defined. PMID- 4323130 TI - Serologic surveillance for adeno-associated satellite virus antibody in military recruits. PMID- 4323131 TI - Changes in phospholipid metabolism which occur as a consequence of mitogenic stimulation of lymphocytes. PMID- 4323132 TI - Immunosuppression by leukemia viruses. V. Ultrastructural studies of antibody forming spleensof mice infected with Friend leukemia virus. PMID- 4323134 TI - Early morphological changes associated with infection by a murine nonthymic lymphatic tumor virus. PMID- 4323133 TI - Immunosuppression by leukemia viruses. VI. Ultrastructure of individual antibody forming cells in the spleens of friend leukemia virus-infected mice. PMID- 4323135 TI - Aflatoxin structure and hepatocarcinogenicity in rainbow trout (Salmo gairdneri). PMID- 4323136 TI - Development of nononcogenic SA7-adenovirus 2 populations that immunize against SA7-transformed cells. PMID- 4323137 TI - Properties of arginase from SV40-induced hamster fibrosarcomas and hamster liver tissues. PMID- 4323138 TI - Further characterization of the WI-L1 and WI-L2 lymphoblastoid lines. PMID- 4323140 TI - So-called C marker chromosome and Epstein-Barr virus, by J. Whang-Peng, P. Gerber, and T. Knutsen, Human Tumor Cell Biology Branch, Clinical Trials, Chemotherapy, National Cancer Institute and Division of Biologics Standards, Bethesda, Maryland 20014. PMID- 4323139 TI - Spontaneous cholangiomas in strain C3H-AvyfB mice and in their hybrids. PMID- 4323141 TI - Isolation and characterization of glioblastoma nuclei and chromosomes in the lyophilized state. PMID- 4323142 TI - Morphological and immunochemical studies of rat glial tumors and clonal strains propagated in culture. PMID- 4323143 TI - Effects of dexamethasone and methylprednisolone on cell cultures of human glioblastomas. PMID- 4323144 TI - Cylindroma in the region of the gasserian ganglion. Case report. PMID- 4323145 TI - Some biochemical characteristics of neuroglia as deduced by glial tumor biochemical analysis. PMID- 4323146 TI - Lipids in brain tumors. PMID- 4323147 TI - [Chronic hydrocyanic poisoning]. PMID- 4323148 TI - [Japanese encephalitis (type B) and Economo encephalitis (type A)]. PMID- 4323149 TI - [Kidney function under the influence of cold]. PMID- 4323150 TI - [Effect of insulin, ACTH and cortisone on the accessory reproductive organs in castrated male rats]. PMID- 4323151 TI - [Virus sensitivity of cells cultured from normal or pathologic rabbit tissue]. PMID- 4323152 TI - [Cancer of the lung on a cicatrix]. PMID- 4323153 TI - [Reye's syndrome: encephalopathies and fatty degeneration of the viscera]. PMID- 4323154 TI - [Disinfectant activity of peracetic acid on the spores of bacteria]. PMID- 4323156 TI - [Rehabilitation in neurology]. PMID- 4323155 TI - [Responses of plasma cortisol, human growth hormone and insulin following intravenous administration of (gly-l)-ACTH(1-18)-octadecapeptide amide (50022 S)]. PMID- 4323157 TI - [Determination of activity in urogenital tuberculosis]. PMID- 4323158 TI - [Biochemical and morphological changes of the liver mitochondria of rats with D3 hypervitaminosis]. PMID- 4323159 TI - Genital herpes and cervical cancer. PMID- 4323160 TI - Protection from 7,12-dimethylbenz(a)anthracene-induced adrenal apoplexy and necrosis by Celite. PMID- 4323161 TI - Histomoniasis in gnotobiotic chickens and turkeys: biological aspects of the role of bacteria in the etiology. PMID- 4323163 TI - [The electron microscopic picture of cerebral capillaries of the human fetus]. PMID- 4323162 TI - Non-specific phosphomonoesterases of Ascaris suum. I. Effect of inhibitors, activators, and chelators. PMID- 4323165 TI - Studies on the oligosaccharide sequence of ribonuclease B. PMID- 4323164 TI - Effect of TC-17, a triazinylstilbene derivative, on the dissemination of mouse tumors. PMID- 4323166 TI - Purification and properties of thymidine monophosphate kinase from mouse hepatoma. PMID- 4323167 TI - Hereditary sensory neuropathy. A clinical and ultrastructural study. PMID- 4323169 TI - Large scale production of Burkitt's lymphoma cells and EB virus in tissue culture. PMID- 4323170 TI - [Electron microscopic study on cultured Burkitt's cells (P3J) and transformed human embryo cells (THE)]. PMID- 4323168 TI - [Empyema of the pleura caused by the anerobe, non-spore-producing bacteria species Sphaerophorus necrophorus]. PMID- 4323171 TI - [The kidney and vitamin A]. PMID- 4323172 TI - Viruses and the kidney. PMID- 4323173 TI - The action of bemegride on presynaptic inhibition. PMID- 4323174 TI - On after-care of paralysed patients in their home. PMID- 4323175 TI - Energy metabolism in the failing canine heart allograft. PMID- 4323176 TI - [Adrenergic system and stress]. PMID- 4323177 TI - [Some current problems in viral hepatitis. The hepatitis antigen]. PMID- 4323178 TI - [Bronchial adenoma. A review and ten cases]. PMID- 4323179 TI - [Nonaldosterone dependent mineralocorticoidism]. PMID- 4323180 TI - [Studies on the course of mental manifestations in anterior pituitary gland insufficiency]. PMID- 4323181 TI - Induction of cellular DNA synthesis by supercoiled SV40 DNA in x-irradiated mouse 3T3 cells. PMID- 4323182 TI - [The clinical picture and electrophysiology of disorders of night sleep (review)]. PMID- 4323183 TI - [Pathomorphological changes of the bony capsule of the labyrinth of the inner ear under the experimental effect of pituitary hormones]. PMID- 4323184 TI - Herpetic iritis: demonstration of virus in the anterior chamber by fluorescent antibody techniques and electron microscopy. PMID- 4323186 TI - Methods for assessing human sleep. PMID- 4323187 TI - [Regulation and functional evaluation of the adrenal-pituitary-hypothalamus axis]. PMID- 4323188 TI - Effect of phytohemagglutinin and prostaglandins on cyclic AMP synthesis in rat lymph node lymphocytes. PMID- 4323189 TI - Radioimmunoassay of glucagon released from isolated guinea-pig islets of Langrrhans incubated in vitro. PMID- 4323190 TI - [Technics of cytoenzymology]. PMID- 4323191 TI - [The effect of coamide on the structure of the nerve elements in the skin and muscles of irradiated animals]. PMID- 4323192 TI - [Intranuclear inclusions in chicken brain neurons upon experimental poisoning with hygromycin B]. PMID- 4323193 TI - [Quantitative detemmination of cerebral blood flow using the gamma scintilation camera]. PMID- 4323194 TI - Squamous-cell carcinoma of the nail bed. A report of two cazes and a discussion of the literature. PMID- 4323195 TI - The myothelia (myoepithelial cells). Normal state; regressive changes; hyperplasia; tumors. PMID- 4323196 TI - Rheumatoid neuropathy. PMID- 4323197 TI - [Nephroblastoma]. PMID- 4323198 TI - [A cholinergic hypnogenic neuronal pathway in the central nervous system]. PMID- 4323199 TI - [Acute necrotizing encephalitis. Clinical and neuropathological study of 3 cases]. PMID- 4323200 TI - [Invasive amebiasis caused by Entamoeba histolytica]. PMID- 4323201 TI - Cholinergic-stimulated alkaline phosphatase secretion and phospholipid synthesis in guinea pig seminal vesicles. PMID- 4323202 TI - Natriuresis in rabbits acutely deprived of water. PMID- 4323205 TI - The effect of anaesthesia on units in the thalamic reticular formation. PMID- 4323204 TI - Action of adrenaline on sweat glands and sudomotor transmission. PMID- 4323203 TI - Interactions of intracranially administered renin or angiotension and other thirst stimuli on drinking. PMID- 4323206 TI - Effect of tetanus toxin in the goldfish. PMID- 4323207 TI - [Medico-legal problems concerning the fetus and infant]. PMID- 4323209 TI - [Peripheral neuropathy with involvement of the cranial nerves without cerbbrospinal fluid changes during a cryptic phase of leukosarcomatosis]. PMID- 4323208 TI - [Blood coagulation and its disorders in the newborn]. PMID- 4323210 TI - Malignant neural elements in a benign cystic teratoma. A case report. PMID- 4323212 TI - [Modified method of angiotensin test]. PMID- 4323211 TI - [Effect of parathyroid hormone on kidney function. I. Animal experiments]. PMID- 4323214 TI - [An unknown complication of hyperthyroidism: peripheral neuropathy]. PMID- 4323213 TI - [Pathophysiological principles of dose selecting and pharmacodynamic properties of insulin preparations for treatment of diabetes]. PMID- 4323215 TI - Growth of equine infectious anemia in a new cell system. PMID- 4323216 TI - Functioning nonchromaffin paraganglioma (chemodectoma) of the urinary bladder. PMID- 4323217 TI - The metabolism of contact insecticides in stored grains. II. 1966-1969. PMID- 4323218 TI - [Pierre Soulie (1903-1970)]. PMID- 4323219 TI - The new quartz-filled resins. PMID- 4323220 TI - The role and specificity of bordetella lipopolysaccharide in immune reactions. PMID- 4323221 TI - [The quantitative relation between virus concentration and serum dilution in virus neutralization studied with Teschen virus by means of tube tissue cultures with regard to fundamental and practical problems]. PMID- 4323222 TI - The effects of lidocaine on inhibition in the cerebral cortex. PMID- 4323223 TI - [Action of polyriboinosinic acid-polyribocytidylic acid bicatenary complex (poly I:C) on infection caused by various viruses in mice]. PMID- 4323224 TI - A specific common chromosomal pathway for the origin of human malignancy. II. AB - A consistent chromosome abnormality exists in 17 human cell lines and in 11 fresh cancers, a finding strongly supportive of our original support of Boveri's concept of a chromosomal imbalance origin of human cancer. This abnormality is in the form of a marked excess of E16 chromosomes per cell, either absolute or in relationship to other chromosome classes. If the ratio of E16 chromosomes to those of other classes be the crucial parameter, several ratios involving E16 chromosomes must be considered as candidates. We feel the choice between such possible ratios might be better made when 100 or more human cancers have been studied, rather than now. It may be that imbalance in E16 chromosomes relative to certain other classes represents a necessary condition for malignant cell behavior, but that more than one such E16 imbalance may be a sufficient condition. PMID- 4323225 TI - Fine structure of an oat cell carcinoma of the lung associated with ectopic ACTH syndrome. AB - Electron-microscopic examination of an oat-cell carcinoma associated with the ectopic ACTH syndrome demonstrated characteristic cytoplasmic granules of 60-240 nm. diameter, consisting of a dense central core separated by a clear halo from an outer investing membrane. Comparison with previously examined non-secretory oat-cell carcinomas showed the granules to be more numerous in the present case. They are considered to represent secretory activity in the tumour. PMID- 4323226 TI - The possible carcinogenic effects of radiations on the uterus. AB - The carcinogenic effects of radium and X-rays on the rat uterus have been investigated. Malignant endometrial tumours, usually adenocarcinomas, were produced in a small proportion of treated rats. One rat treated with X-rays developed an adeno-sarcoma (possibly carcino-sarcoma) of the endometrium. Benign mixed polypoidal endometrial tumours occurred also in radium and X-ray treated rats and in non-radiated controls; radiation increased the incidence of these tumours and may have induced malignant transformation in some. The incidence of lymphosarcomas and mammary tumours in the strain of rat used appeared to be influenced by radiation treatment.Review of the literature of human cases of mixed uterine tumours showed that in women over 40 years, more than one-fifth of the reported cases had a history of previous pelvic radiation; with other kinds of uterine malignancy a history of prior radiation treatment was considerably less. The results of our experiments enhance the suspicion that radiations are one factor in the causation of uterine cancer, especially mixed tumours. PMID- 4323227 TI - A preliminary report on the thymidine labeling indices and kinetics of cell proliferation in selected Morris hepatomas. AB - The 1 hour thymidine labeling indices have been determined for 8 hepatomas which have growth rates which vary by a factor of 14. The indices for these tumors vary only by a factor of 4. Little correlation was found. Preliminary results have been obtained on the kinetics of cell proliferation of the rapidly growing Hepatoma H-35tc(2). The tumor transfer time is 0.7 months and the growth rate is 7.0 cm. per month. The calculated values for times in different phases of the cell cycle for H-35tc(2), assuming a log normal distribution for phase duration, were as follows: T(g1) (Gap I)-11.0 hours; T(s) (DNA synthetic period)-6.6 hours; T(g2) (Gap II)-4.2 hours; T(m) (mitotic time)-0.4 hours. Therefore, the total time, T(c), for one cell cycle was calculated to be 22.2 hours. The potential doubling time was calculated to be 43 hours. The GF (growth fraction) was estimated to be 53 per cent which would suggest that approximately one-half the total cell population is nonproliferating. PMID- 4323228 TI - Enzyme studies on tumour cell suspensions. AB - Activities of glucose-6-phosphatase, fructose 1,6-diphosphatase, ornithine transcarbamylase, arginase and xanthine oxidase were measured in thioacetamide induced primary hepatoma and its tumour cell suspension. It was observed that the percentage decrease in the activities of all the enzymes in tumour cell suspension was far more than that observed in tumour tissue. However, in these studies no qualitative difference was observed between the parenchymal cells and the tumour cells. PMID- 4323229 TI - Studies on the extracellular alkaline phosphatase of Micrococcus sodonensis. I. Isolation and characterization. PMID- 4323230 TI - Crystalline pyruvate oxidase from Escherichia coli. II. Activation by phospholipids. PMID- 4323231 TI - Role of cyclic adenosine 3',5'-monophosphate in the induction of hepatic enzymes. II. Effect of N6,O2'-dibutyryl cyclic adenosine 3'-5'-monophosphate on the kinetics of ribonucleic acid synthesis in purified rat liver nuclei. PMID- 4323232 TI - Regulatory mechanisms involving nicotinamide adenine nucleotides as allosteric effectors. IV. Physicochemical study and binding of ligands to citrate synthase. PMID- 4323233 TI - Pyruvate kinase of the spore-forming bacterium, Bacillus licheniformis. I. Purification, stability, regulation of synthesis, and evidence for multiple molecular states. PMID- 4323234 TI - Properties of a fused protein formed by genetic manipulation. Histidinol dehydrogenase-imidazolylacetol phosphate: L-glutamate aminotransferase. PMID- 4323235 TI - Ordered binding of substrates to yeast aldehyde dehydrogenase. PMID- 4323236 TI - The glucagon-sensitive adenyl cyclase system in plasma membranes of rat liver. II. Comparison between glucagon- and fluoride-stimulated activities. PMID- 4323238 TI - Studies on the chemical and enzymatic modification of glycoproteins. A general method for the tritiation of sialic acid-containing glycoproteins. PMID- 4323237 TI - The glucagon-sensitive adenyl cyclase system in plasma membranes of rat liver. 3. Binding of glucagon: method of assay and specificity. PMID- 4323240 TI - Reversal of the adenosine triphosphate and adenosine diphosphate inactivation of liver fructose 1,6-diphosphatase by 3-phosphoglycerate. PMID- 4323239 TI - Actinomycin-insensitive stimulation of protein synthesis in rat anterior pituitary in vitro by dibutyryl adenosine 3',5'-monophosphate. PMID- 4323241 TI - Activation of thyroid adenyl cyclase by long-acting thyroid stimulator. PMID- 4323243 TI - Sir William writes about massive abdominal tumors in children. PMID- 4323242 TI - Behavioral state and plasma cortisol response in the human newborn. PMID- 4323244 TI - [On the neuromuscular block caused by intra-arterial injection of acetylcholine. Effects of preliminary treatment with ACTH]. PMID- 4323245 TI - [Studies of the changes of excitability of cortical thalamic neurons during the sleep-waking cycle]. PMID- 4323246 TI - [Presynaptic and postsynaptic changes in the ncleus ventralis lateralis during the sleep-waking cycle]. PMID- 4323247 TI - [Antidromic sensory conduction rate of the ulnar nerve i normal and pathological conditions]. PMID- 4323248 TI - [Phase V sleep deprivation in epileptic subjects: changes of discharges and of nocturnal sleep organization]. PMID- 4323249 TI - [Polygraphic study during spontaneous nocturnal sleep in a case of bulbar myoclonus]. PMID- 4323250 TI - Glycopeptides from the surface of control and virus-transformed cells. AB - Glycopeptides were removed by trypsin digestion from the surface of control cells and cells transformed by Rous sarcoma virus, murine sarcoma virus, or polyoma virus. After digestion with pronase, the glycopeptides were analyzed by gel filtration. The elution profiles suggest that there are differences in the glycopeptides from the surface of control cells and those from transformed cells. PMID- 4323251 TI - Interaction of rheumatoid factor with infectious herpes simplex virus-antibody complexes. AB - Rheumatoid factor, a human immunoglobulin of the IgM class, failed to attach to herpes simplex virus but did attach to infectious complexes composed of herpes simplex virus and antibody to herpes simplex virus. These newly formed complexes of infectious virus, antiviral antibody, and rheumatoid factor could be neutralized by complement or by antibody to human IgM. The ability of rheumatoid factor to enhance virus neutralization in the presence of complement represents a hitherto unrecognized biological role for rheumatoid factor. PMID- 4323253 TI - Isolation of a herpesvirus from the canine genital tract: association with infertility, abortion and stillbirths. PMID- 4323252 TI - Enzyme control and macromolecular assembly. PMID- 4323254 TI - On the morphological substrate of pain sensibility of the epicardium. PMID- 4323255 TI - [Insulin-excreting neoplasms of the pancreas (4 cases report)]. PMID- 4323256 TI - [Sporulation medium for Clostridium perfringens]. PMID- 4323257 TI - [Cytotoxicity of silica dust and mixed dust for guinea pig alveolar macrophages in vitro. Attempt at quantitative estimation]. PMID- 4323258 TI - [Vascular endothelium: light microscopy, ultrastructure and permeability to lipids]. PMID- 4323259 TI - [Changes in the eyes in generalized cytomegaly]. PMID- 4323260 TI - [Siderotic variant of angiofibroxanthoma (Glazunov's angiofibromatosis)]. PMID- 4323261 TI - Monitorying poultry vaccines for biocontamination with lymphoid leukosis virus. PMID- 4323262 TI - Cell wall phospholipid and viomycin resistance in Rhizobium meliloti. PMID- 4323263 TI - A functional role of polyADPR in DNA synthesis. PMID- 4323264 TI - Stimulation of adenosine 3',5'-monophosphate-dependent and guanosine 3',5' monophosphate-dependent protein kinases by some analogs of adenosine 3',5' monophosphate. PMID- 4323265 TI - Distribution of mitochondrial enzymes after isopycnic centrifugation of a rat liver mitochondrial fraction in a sucrose gradient: influence of the speed of centrifugation. PMID- 4323266 TI - Structural studies of porcine malate dehydrogenase. Selective chemical modification. PMID- 4323267 TI - [Effect of 6-methylthiouracil and L-thyroxine on prolongation of the life of rats following inoculation with cerebellar glioblastoma multiforme]. PMID- 4323268 TI - A sensitive method for the detection of adenine compounds separated by paper or thin-layer chromatography. PMID- 4323269 TI - A new craniodigital syndrome with mental retardation. PMID- 4323270 TI - Effect of synthetic beta 1-24 corticotropin on growth hormone release in children. PMID- 4323271 TI - Synaptic connexions of alpha extensor motoneurones with ipsilateral and contralateral cutaneous nerves. AB - 1. Synaptic responses of alpha extensor motoneurones to stimulation of cutaneous nerves of the hind limb were recorded from the lumbosacral region in decerebrate and decerebrate-spinal unanaesthetized cats. Responses to ipsi- and contralateral stimulation are compared.2. Usually a single volley in an ipsilateral cutaneous nerve led to an inhibitory post-synaptic potential while one in a contralateral cutaneous nerve led to an excitatory post-synaptic potential or to discharge of the cell, thus demonstrating the classical reciprocal innervation pattern. In some cells either ipsilateral or crossed spinal action was of opposite sign to normal.3. Tests using graded stimulation showed the range of myelinated afferents associated with crossed spinal actions to be narrower than that for ipsilateral actions; for the sural nerve the ranges are 1-6 mu and 1-9 mu respectively. A substantial proportion of the coarser myelinated afferents do not make connexion with alpha motoneurones on either side of the cord; in the sural nerve this proportion includes the range 10-17 mu.4. Central transmission times for ipsilateral and crossed-spinal actions were estimated after making systematic allowance for conduction time to the cord in the associated cutaneous afferents. Mean values for inhibitory pathways from ipsilateral cutaneous nerves were about 2 msec, while those for crossed spinal facilitatory pathways were notably greater, 3-5 msec.5. Crossed spinal actions were more profoundly depressed by anaesthesia than were corresponding ipsilateral actions.6. Interpretation of the results was aided by a separate study of the input to the spinal cord; stimulus strength is related to the diameters of the cutaneous fibres excited and to peripheral conduction time in those fibres. PMID- 4323272 TI - A sex difference in the response of the carotid body chemoreceptors to pressor agents. PMID- 4323274 TI - Changes in electrical activity during fatiguing voluntary isometric contraction of human muscles. PMID- 4323273 TI - Some effects of nerve stimulation andhemicholinium on quantal transmitter release at the mammalian neuromuscular junction. AB - 1. Rat phrenic nerve-diaphragm preparations have been used to assess some effects of prolonged nerve stimulation on transmitter release.2. The amplitude of the end plate potentials evoked by prolonged repetitive nerve stimulation fell gradually during stimulation. Most of this fall was due to a reduction in the number of transmitter quanta released by each nerve impulse; however there was also a small reduction in the muscle cell depolarization produced by each quantum of transmitter.3. Repetitive nerve stimulation also produced a small reduction in the amplitude of the miniature end-plate potentials. Recovery of amplitude occurred within about 7-8 min of ceasing stimulation.4. A much greater reduction in miniature end-plate potential amplitude accompanied prolonged nerve stimulation if hemicholinium was present in the bathing solution.5. Estimates of the ;readily available transmitter' (Elmqvist & Quastel, 1965b) were made at intervals following prolonged nerve stimulation. Readily available transmitter was reduced, and recovered over approximately 15 min.6. The relationship of these changes to the changes in nerve terminal synaptic vesicle numbers and volumes induced by similar prolonged nerve stimulation (Jones & Kwanbunbumpen, 1970) is discussed. PMID- 4323275 TI - [Differential diagnosis of primary sarcomas and glioblastomas of the brain]. PMID- 4323276 TI - [Advantages of a painless and colorless topical agent in otorhinolaryngology]. PMID- 4323277 TI - Genital herpesvirus hominis Type 2 infection of monkeys. PMID- 4323278 TI - Management of pregnancy complicated by genital herpes virus infection. PMID- 4323279 TI - Neonatal adrenal insufficiency associated with maternal Cushing's syndrome. PMID- 4323280 TI - Congenital islet cell adenoma causing hypoglycemia in a newborn. PMID- 4323281 TI - Ectopic hormone syndromes associated with tumors in childhood. PMID- 4323282 TI - Carcinoma of the tongue. PMID- 4323283 TI - An adolescent inpatient program. Guidelines and ethics. PMID- 4323284 TI - Pathogenicity in mice of foot-and-mouth disease virus selected by adsorption with calf kidney. PMID- 4323285 TI - Airborne transmission of smallpox. PMID- 4323286 TI - [Study of cholinesterase activity of the nerve and subcellular fractions of skeletal muscles in rabbits with reversible distrubance in motor functions of the muscles]. PMID- 4323288 TI - [Changes in the composition of blood in rats affected by neptunium-237]. PMID- 4323287 TI - [Phosphohydrolase of phosphatic acid in skeletal muscles and myocardium]. PMID- 4323289 TI - [Hygienic microbiological investigations with "Vitahum" composts]. PMID- 4323290 TI - Some observations on congenital teratomata and ectopic cerebromata. PMID- 4323291 TI - [Interaction of angiotensin II with the sympathetic nervous system]. PMID- 4323292 TI - Respiratory mechanisms in the Flexibacteriaceae: terminal oxidase systems of Saprospira grandis and Vitreoscilla species. AB - Particles from both Saprospira grandis and Vitreoscilla species, obtained by high pressure extrusion and sonic treatment, respectively, actively catalyze the oxidation of reduced nicotinamide adenine dinucleotide (NADH) and succinate with O(2). These activities are inhibited by cyanide but not by antimycin; Saprospira is also amytal- and rotenone-insensitive. Vitreoscilla preparations were unable to oxidize mammalian ferrocytochrome c and reduced tetramethyl-p phenylenediamine, whereas the Saprospira preparations did so actively. Low temperature (77 K) difference spectroscopy of Vitreoscilla cells and particles indicates the presence of three maxima in the cytochrome alpha-region at 554, 558, and 562 nm. All three cytochromes are active in NADH and succinate oxidation, but none is ascorbate reducible. Cytochrome o is the only CO-binding pigment present and is probably the terminal oxidase; it has properties similar to the cytochrome o isolated in solubilized form from this organism. Saprospira cells and membranes exhibit four cytochrome absorption bands whose maxima are at 550, 554, 558, and 603 nm at 77 K. The latter component has not been noted previously. NADH and succinate reduce all four cytochromes, but ascorbate reduces only the 550- and 603-nm pigments. CO spectra indicate the presence of cytochrome a,a(3) which is probably the oxidase. A second CO-binding pigment is present which is not a peroxidase but may be a cytochrome. PMID- 4323294 TI - Fine structure of protoplasts and L-forms of Clostridium botulinum types A and E. AB - Spherical bodies, that are obtained by adding penicillin and lysozyme to Clostridium botulinum types E and A cultures which are growing in an osmotically stabilized medium, are shown to be protoplasts by electron microscopy. The L forms of these two culture types have morphologically different inclusion bodies. PMID- 4323293 TI - Composition of the sulfur particle of Chromatium vinosum strain D. AB - Sulfur particles were isolated from the purple sulfur photosynthetic bacterium, Chromatium vinosum strain D. The composition of these particles was determined to be 93% sulfur, 5% protein, and 0.6% lipid. Gel electrophoresis indicated the presence of a single protein species with a molecular weight of 13,500 daltons. From these results, the sulfur particle is postulated to be bounded by a membrane consisting entirely of protein. PMID- 4323295 TI - Comparative physiologial studies of the yeast and mycelial forms of Histoplasma capsulaum: uptake and incorporation of L-leucine. AB - l-Leucine entered the cells of both morphological forms of Histoplasma capsulatum by a permease-like system at low external concentrations of substrate. However, at levels greater than 5 x 10(-5)m l-leucine, the amino acid entered the cells both through a simple diffusion-like process and the permease-like system. The rate of the amino acid diffusion into yeast and mycelial forms appeared to be the same, whereas the initial rate of accumulation through the permease-like system was 5 to 10 times faster in the mycelial phase than it was in the yeast phase. The Michaelis constants were 2.2 x 10(-5)m in yeast phase and 2 x 10(-5)m in mycelial phase cells. Transport of l-leucine at an external concentration of 10( 5)m showed all of the characteristics of a system of active transport, which was dependent on temperature and pH. Displacement or removal of the alpha-amino group, or modification of the alpha-carboxyl group abolished amino acid uptake. The process was competitively inhibited by neutral aliphatic side-chain amino acids (inhibition constants ranged from 1.5 x 10(-5) to 6.2 x 10(-5)m). Neutral aromatic side-chain amino acids and the d-isomers of leucine and valine did not inhibit l-leucine uptake. These data were interpreted to mean that the l-leucine transport system is stereospecific and is highly specific for neutral aliphatic side-chain amino acids. Incorporation of l-leucine into macromolecules occurred at almost the same rate in both morphological forms of the fungus. The mycelial phase but not the yeast phase showed a slight initial lag in incorporation. In both morphological forms the intracellular pool of l-leucine was of limited capacity, and the total uptake of the amino acid was a function of intracellular pool size. The initial rate of l-leucine uptake was independent of the level of intracellular pool. Both morphological forms deaminated and degraded only a minor fraction of the accumulated leucine. PMID- 4323296 TI - Deficiencies of chromatophore proteins in some mutants of Rhodopseudomonas spheroides with altered carotenoids. AB - Chromatophore proteins of a wild type and three mutant strains of Rhodopseudomonas spheroides were examined by polyacrylamide gel electrophoresis in the presence of sodium dodecyl sulfate. The mutants consisted of a green and a blue-green one, whose phenotypes were essentially the same as those of known mutants, and a brown one, which may be a double mutant and represents a new phenotype. Wild-type chromatophores contained at least six major and seven minor protein bands, with molecular weights ranging from 10,000 to 65,000. The green mutant contained the same protein bands in the same relative quantities. The brown mutant had one protein completely missing and no other alterations. The blue-green mutant was deficient in a different protein, and had reduced quantities of all proteins with molecular weights less than 25,000. Chromatophores were separated into a fraction containing the reaction centers and a fraction containing the light-harvesting bacteriochlorophyll by treatment with sodium dodecyl sulfate. Eight of the proteins were found only in the reaction center fraction, one was only in the light-harvesting fraction, and the remainder were present in both fractions. The protein missing from the brown mutant was found to be a component of the reaction center fraction, whereas the proteins which were missing from the blue-green mutant were all components of the light harvesting fraction. Some implications for the structure and biogenesis of chromatophores are discussed. PMID- 4323297 TI - Characterization and genetic analysis of mutant strains of Escherichia coli K-12 accumulating the biquinone precursors 2-octaprenyl-6-methoxy-1,4-benzoquinone and 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinone. AB - The ubiquinone precursors, 2-octaprenyl-6-methoxy-1,4-benzoquinone and 2 octaprenyl-3-methyl-6-methoxy-1,4-benzoquinone, were isolated from ubiquinone deficient mutants of Escherichia coli and identified by nuclear magnetic resonance and mass spectrometry. Mutants accumulating 2-octaprenyl-6-methoxy-1,4 benzoquinone and 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinone were shown to carry mutations in genes designated ubiE and ubiF, respectively. The ubiE gene was shown to be cotransducible with metE (minute 75) and close to two other genes concerned with ubiquinone biosynthesis. The ubiF gene was located close to minute 16 by cotransduction with the lip, gltA, and entA genes. PMID- 4323298 TI - Isolation, culture, and fermentation characteristics of Selenomonas ruminantium var. bryantivar. n. from the rumen of sheep. AB - Large forms of Selenomonas sp. were isolated from the sheep rumen on a rumen fluid-glucose-agar medium by using a differential centrifugation technique to purify the inoculum. The cells from the six isolated strains were curved, gram negative, strictly anaerobic crescents, and rapidly motile by flagella attached to the concave side of the cell. One or more of the volatile fatty acids were essential for growth. None of the strains produced indole or reduced nitrate. All strains grew on fructose, glucose, mannose, cellobiose, maltose, sucrose, and salicin. Fermentation end products from glucose were mainly lactate, acetate, propionate, and formate. Small amounts of succinate were formed. The final pH in a glucose medium ranged between 4.3 and 4.5. On the basis of the sugar fermentation characteristics and the capacity to form hydrogen sulfide from cysteine, it is suggested that one of the strains is a large form of Selenomonas ruminantium. The other five strains are designated S. ruminantium var. bryanti, var. n. PMID- 4323299 TI - Use of antibody to membrane adenosine triphosphatase in the study of bacterial relatioships. AB - An antiserum to Ca(2+)-activated adenosine triphosphatase from membranes of Micrococcus lysodeikticus cross-reacted in agar gels with membrane adenosine triphosphatases from other pigmented micrococci and related species. Species of Micrococcus and Sarcina showed different levels of inhibition of adenosine triphosphatase activities in heterologous reactions with antiserum. Inter- and intraspecific relationships based on the inhibition reaction were compared with an independent parameter, namely the quantitative and qualitative composition of the bacterial membrane phospholipids and fatty acids. The guanine plus cytosine contents in the deoxyribonucleic acid of the species studied correlated well with the serological cross-reactivity of adenosine triphosphatases from their membranes. The types of cross-bridges found in the peptidoglycans of these cocci were also compared with the other properties. The results suggest that an antiserum specific for a major membrane protein may be a reliable and most useful adjunct in studying bacterial serotaxonomy. PMID- 4323301 TI - The incidence of herpes zoster antibodies in patients with peripheral facial palsy. PMID- 4323300 TI - Lactate metabolism by Veillonella parvula. AB - A strain of Veillonella parvula M4, which grows readily in lactate broth without a requirement for carbon dioxide, has been isolated from the oral cavity. Anaerobic, washed cells of this organism fermented sodium lactate to the following products (moles/100 moles of lactate): propionate, 66; acetate, 40; carbon dioxide, 40; and hydrogen, 14. Cells grew readily in tryptone-yeast extract broth with pyruvate, oxaloacetate, malate, and fumarate, but poorly with succinate. The fermentation of pyruvate, oxaloacetate, or lactate plus oxaloacetate by washed cells resulted in the formation of propionate and acetate in ratios significantly lower than those observed with lactate as the sole carbon source. This was primarily due to increased acetate production. Cell-free extracts were unable to degrade lactate but metabolized lactate in the presence of oxaloacetate, indicating the presence of malic-lactic transhydrogenase in this organism. Lactic dehydrogenase activity was not observed. Evidence is presented for oxaloacetate decarboxylase and malic dehydrogenase activities in extracts. PMID- 4323302 TI - The auriculotemporal syndrome beginning in infancy. PMID- 4323303 TI - Some physiological and pharmacological characteristics of the motor transmission in the guinea-pig vas deferens. PMID- 4323305 TI - The effect of cervical cord transection on cardiovascular responses mediated by the vagus nerves. PMID- 4323304 TI - Effects of lowered temperature on the responses of the smooth muscle of the isolated, blood-perfused dog's spleen to sympathetic nerve stimulation. PMID- 4323306 TI - The contribution of small and large vesicles to noradrenaline release. PMID- 4323307 TI - Ionic mechanism of post-tetanic potentiation at the neuromuscular junction of the frog. AB - 1. Transmitter release at the frog neuromuscular junction was studied after sodium influx in nerve and muscle was abolished by tetrodotoxin (TTX).2. In the presence of TTX, transmitter release evoked by electrotonic depolarization of the nerve terminal was potentiated following presynaptic stimulation by a train of depolarizing pulses.3. Post-tetanic potentiation (PTP) in the presence of TTX appeared no different from that observed in control (TTX-free) muscles. The magnitude as well as the time course of PTP was dependent on the number of tetanic stimuli and on temperature of the medium when sodium influx was inhibited by TTX.4. When external sodium was replaced by an isotonic calcium chloride solution PTP was still present. Ionophoretic application of calcium during tetanic nerve stimulation and increase in the intensity of the depolarizing pulse of the train, which presumably enhances calcium movements into nerve endings, caused a large increase in the duration of PTP.5. It is concluded that PTP does not require sodium but depends on movement of calcium from the external medium into the nerve terminal. PMID- 4323308 TI - On the control of glycogenolysis in mammalian nervous tissue by calcium. AB - 1. A study has been made of the increase in fluorescence of the desheathed cervical vagus nerve that occurs after electrical stimulation (usually 5 sec at 30/sec) of its non-myelinated fibres.2. At room temperature this increase in fluorescence is normally masked by the decrease in fluorescence caused by mitochondrial oxidative phosphorylation. However, at higher temperatures (30-35 degrees C) the increasing fluorescence phase predominates and the net change on stimulation is an increase.3. At room temperature the increase in fluorescence is seen clearly only when ATP splitting has been prevented by ouabain, by bathing the nerve in lithium-Locke solution, or when oxidative phosphorylation has been prevented by metabolic inhibitors.4. The increasing fluorescence response is absent when calcium is removed from the external medium; it increases with increasing calcium concentration.5. It is argued that the increasing fluorescence response is due to an increase in glycogenolysis (leading to an increase in the reduced pyridine nucleotide concentration) brought about by the increased calcium entry during the action potential. This calcium presumably increases the activity of phosphorylates a or phosphofructokinase.6. Calcium entry also speeds mitochondrial oxidative phosphorylation. PMID- 4323309 TI - The release of gamma-aminobutyric acid during inhibition in the cat visual cortex. AB - 1. The release of gamma-aminobutyric acid (GABA) from the surface of the posterior lateral gyrus of the cerebral cortex was measured by a sensitive enzymic fluorimetric assay procedure. Experiments were performed with anaesthetized cats during resting conditions and during cortical inhibition produced by electrical stimulation of the brain surface or of the lateral geniculate nucleus (l.g.n.).2. The average resting release of endogenous GABA was 0.20 n-mole/ 7 min.cm(2) cortex; this was increased during stimulation of both the cortical surface (2.9 times resting release during monopolar stimulation and 7.4 times resting release during bipolar stimulation) and the l.g.n. (5.7 times resting release).3. Removal of calcium ions from the collection fluid did not affect the resting release of endogenous GABA but prevented the increase in GABA release normally evoked by stimulation of the cortical surface.4. The stimulus parameters used to increase the release of GABA also inhibited the glutamate induced firing of single cells in the visual cortex and this inhibition was abolished in the absence of calcium ions.5. In three experiments the total amino acid content of cortical samples was examined using an amino acid analyser. With the exception of GABA, there were no significant differences between the rates of release of any other detected amino acids during periods with and without electrical stimulation of the cortex.6. It is suggested that since the release of GABA observed during inhibitory stimulation of the cortex is calcium-dependent and specific, it may originate from inhibitory nerve terminals in the cortex. The present findings support the view that GABA is a central inhibitory neurotransmitter. PMID- 4323310 TI - Electrophysiological studies of neuromuscular transmission in hereditary 'motor end-plate disease' of the mouse. AB - 1. Studies have been made on isolated nerve-muscle preparations from mice with hereditary ;motor end-plate disease'.2. Spontaneous fibrillation was observed in the isolated preparation.3. Muscles gave only a weak twitch or failed to contract in response to nerve stimulation. Direct stimulation of muscles caused a twitch response which had a slower time course than normal. Peripheral nerve conduction was normal.4. Intracellular recording from single muscle fibres showed that with longer survival of the animal an increasing proportion of fibres failed to show end-plate potentials or action potentials in response to nerve stimulation.5. Miniature end-plate potentials (m.e.p.p.s) were recorded in almost all muscle fibres including those in which neuromuscular transmission had failed. The frequency of m.e.p.p.s was greater than normal, was not increased by tetanic stimulation of the nerve but was increased by a raised external potassium concentration.6. Muscle fibres were supersensitive to acetylcholine.7. The results suggest that the muscular weakness in this disease is due to the failure of nerve action potentials to invade motor nerve terminals so that muscle fibres become ;functionally denervated'. PMID- 4323312 TI - Recurrent viral infection (reinfection). PMID- 4323311 TI - [Changes in the bioelectrical activity of vagus nerve and sympathetic nerve afferent fibers in short-term myocardial ischemia]. PMID- 4323313 TI - Identification of 1,25-dihydroxycholecalciferol, a new kidney hormone controlling calcium metabolism. PMID- 4323314 TI - Effects of presleep procedures and cognitive style on dream content. PMID- 4323315 TI - The effects of the intraventricular administration of angiotensin II, bradykinin and eledoisin on the arterial blood pressure, respiratory movements and electrocardiogram. PMID- 4323316 TI - [Psychogenic postoperative urinary retention]. PMID- 4323317 TI - [Erythremic myelosis, acute leukemia and panmyelosis]. PMID- 4323318 TI - [Zieve's syndrome. Apropos of 2 cases]. PMID- 4323319 TI - [Contribution of electronystagmography to the diagnosis of spasmophilia]. PMID- 4323320 TI - [Demonstration of a malrotation in the angiogram]. PMID- 4323321 TI - Etiology of pneumonia in nonrecruit military personnel. PMID- 4323323 TI - Thyroid lymphography. PMID- 4323324 TI - [Early rehabilitation by intensive follow-up therapy]. PMID- 4323322 TI - [Histology and ultrastructure of herpes gestationis]. PMID- 4323325 TI - [Trophoblastic disease in the San Juan de Dios Hospital. Cucuta, Colombia]. PMID- 4323326 TI - Symposium on corneal infection and immunity. The Association for Research in Vision and Ophthalmology and National Society for the Prevention of Blindness. Collagenase and corneal ulcers. PMID- 4323327 TI - Ocular herpes simplex. PMID- 4323328 TI - Enhancement of fatty acid oxidation and medium-chain fatty acyl coenzyme A synthetase by adenine nucleotides in rat heart homogenates. PMID- 4323329 TI - [Malignant hepatoma with major hypoglycemia]. PMID- 4323330 TI - Studies of the effect of nicotinic acid on cyclic nucleotide phosphodiesterase activity in rat heart and adipose tissue. PMID- 4323331 TI - Increased lipolytic response to norepinephrine in isolated brown fat cells after sympathetic denervation. PMID- 4323332 TI - The effect of isoprenaline, theophylline and adenosine 3', 5'-monophosphate on the isolated vas deferens of the guinea-pig. PMID- 4323333 TI - [Immunological aspects in experimental oncology]. PMID- 4323334 TI - [Myocardial infarct in the follow-up therapy]. PMID- 4323335 TI - [Verification of gerontotherapeutic effects. (Clinical experimental study on Kavaform)]. PMID- 4323336 TI - [Pathogenesis of the mucous folds adjoining cancers of the rectum at onset]. PMID- 4323337 TI - [Supratentorial intraventricular tumors]. PMID- 4323338 TI - Comparative histochemical observations on the contributions of the acrosomal vesicle and granule to the acrosomal cap in the spermatozoa of mammals. PMID- 4323339 TI - [Fine structure of medullary cords and tubes in the ovary of juvenile and mature sows. (Sus scrofa L.)]. PMID- 4323340 TI - An ultrastructural study of the neurosecretory cells of the medial vascular preiasmatic gland, the preoptic recess and the anterior part of the suprachiasmatic area. I. Cytoplasmic inclusions resembling nucleoi. PMID- 4323341 TI - Theoretical implications of the use of L-dopa in parkinsonism. A review. PMID- 4323342 TI - A survey of tumors of the central nervous system in Iceland during the 10-year period 1954-1963. PMID- 4323343 TI - [Studies on the inhibition of the cytotoxic effect of quartz using mineral substances, with special emphasis on aluminum]. PMID- 4323344 TI - Primary Clostridium welchii meningitis. PMID- 4323345 TI - Characterization of a canine adenovirus hemagglutinin. PMID- 4323346 TI - The phospholipid composition of Rhizobium japonicum. PMID- 4323347 TI - Effects of exogenous histones upon the induction of tryptophan pyrrolase and tyrosine transaminase in liver and Morris hepatomas. PMID- 4323348 TI - Detection of a reactive intermediate in the reaction between DNA and hydroxyurea. PMID- 4323349 TI - Retention of metabolic regulation in the hyperplastic hepatic nodule induced by N 2-fluorenylacetamide. PMID- 4323350 TI - Morphology of virus-like particles persisting in murine ependymoblastoma in vitro. PMID- 4323351 TI - Immunology of spontaneous mammary carcinomas in mice: immunogenicity of mammary tumor virus-contaning tissues in mammary tumor virus-free C3H-2 hosts. PMID- 4323352 TI - Search for cross-reacting antigenicity between mammary tumor virus-induced mammary tumors and embryonic antigens: effect of immunization on development of spontaneous mammary tumors. PMID- 4323353 TI - RNA synthesis induction in cell culture by a tumor promoter. PMID- 4323354 TI - Carcinogenicity of N-[4-(5-nitro-2-furyl)-2-thiazolyl] acetamide in female rats. PMID- 4323355 TI - The role of the dermis in the induction of neoplasia by Shope papilloma virus. PMID- 4323356 TI - A new colorimetric method for blood alcohol determination. PMID- 4323357 TI - Granular cell myoblastoma: report of four cases. PMID- 4323358 TI - [Exfoliative cytology in semeiological studies of mammary neoplastic lesions]. PMID- 4323359 TI - [Phospho-calcium metabolism and the endocrine glands]. PMID- 4323360 TI - [Phospho-calcium metabolism disorders in acromegaly]. PMID- 4323361 TI - Ischemic nerve injury. Experimental studies on intraneural microvascular pathophysiology and nerve function in a limb subjected to temporary circulatory arrest. PMID- 4323363 TI - [The adsorption of soil bacteria on substrates with special reference to secondary clay minerals and ionic exchangers on the basis of artifical resin. 2]. PMID- 4323362 TI - [The adsorption of soil bacteria on substrates with special reference to secondary clay minerals and ionic exchangers on the basis of artifical resin. 1]. PMID- 4323364 TI - [Investigation for purpose of comparison of the fungicidal influence of sodium fluosilicate, calcium fluoride, sodium fluoride, tributyl tin acetate and tetramethylthiuramide sulphide in mixtures with cement]. PMID- 4323365 TI - Percutaneous needle biopsies of the liver. PMID- 4323366 TI - [Hemolysis of possible viral origin (adenovirus) in a patient with glucose-6 phosphate-dehydrogenase deficiency]. PMID- 4323367 TI - Comparison of effects of corticotrophin and corticosteroids on pituitary-adrenal function. PMID- 4323368 TI - Influence of immunological factors in respiratory syncytial virus disease. PMID- 4323369 TI - Adenoviral infection in military recruits. PMID- 4323370 TI - Maternal virus infection and congenital anomalies. PMID- 4323371 TI - Recovery of simian virus 40 from cloned cultures of tumor cells. PMID- 4323372 TI - Cationic modulation of the inactivation of poliovirus by heat. PMID- 4323373 TI - Enteroviral etiology of the paralytic poliomyelitis syndrome. PMID- 4323374 TI - Seasonal patterns of acute infection in Tecumseh, Mich. PMID- 4323375 TI - Interstitial hypertrophic neuropathy. Biochemical study of the peripheral nervous system. PMID- 4323376 TI - Distribution of cyclic adenosine monophosphate in rat brain. PMID- 4323377 TI - Experimental progressive compression neuropathy in the rabbit. Histologic and electrophysiologic studies. PMID- 4323378 TI - Peripheral polyneuropathy, high and low molecular weight IgM, and amyloidosis. PMID- 4323379 TI - Von Recklinghausen's neurofibromatosis. PMID- 4323380 TI - Pyodermite vegetante of Hallopeau with ulcerative colitis persisting after panproctocolectomy and controlled only by A.C.T.H. therapy. PMID- 4323381 TI - Nervous regulation of factor-VIII levels in man. PMID- 4323382 TI - The prevention of infection in appendicectomy wounds. PMID- 4323383 TI - The activity of some chemical disinfectants against Talfan virus and porcine adenovirus type 2. PMID- 4323384 TI - Studies on intestinal protozoa of domestic pigs in the Teheran area of Iran. PMID- 4323385 TI - A quantitative approach to the study of circulatory abnormality, especially of hypertension. PMID- 4323386 TI - Subcellular particles in tumors. IV. Lysosomes in hepatoma HC and Morris hepatomas 7794A, 7794B, 5123A, 7316A and 16. PMID- 4323387 TI - The histopathology of tumors induced by PARA-adenovirus 7 transformed cell clones. PMID- 4323388 TI - Glycolysis in Litomosoides carinii, the filarial parasite of the cotton rat. PMID- 4323389 TI - Haematoloechus medioplexus: enzymatic oxidation of 3,3'-diaminobenzidine in mitochondria. PMID- 4323390 TI - Malarial parasite metabolism: the glutamic acid dehydrogenase of Plasmodium berghei. PMID- 4323391 TI - Parasitological review. Electron transport systems and mitochondrial DNA in Trypanosomatidae: a review. PMID- 4323392 TI - [The effect of adrenocorticotropic hormone on renal oxygen tension]. PMID- 4323393 TI - [The function of the lymph node barrier in humans. Studies with Cr51-labeled erythrocytes]. PMID- 4323394 TI - [Persistent virus infections]. PMID- 4323395 TI - Mobilization of fatty acids in genetically obese rats. AB - The mobilization of fatty acids has been studied in genetically obese rats of the Zucker strain and in control obese animals with bilateral destructive lesions in the hypothalamus. The body weight and size of adipose cells did not differ significantly between the genetically obese rats and the obese controls. Weight loss in control and genetically obese rats was identical during a 1 month fast. The release of glycerol and the rise in free fatty acids in adipose tissue incubated in vitro were similar in tissue from genetic and hypothalamic obese rats. Epinephrine, theophylline, and dibutyryl cyclic adenosine monophosphate all augmented lipolysis, and the effects were usually greater in the tissues from genetically obese rats. PMID- 4323396 TI - Molecular species of mono-, di-, and triphosphoinositides of bovine brain. AB - The mono-, di-, and triphosphoinositides of bovine brain were isolated by chromatography on columns of DEAE-cellulose, alumina, and silicic acid. The major molecular species in each phosphoinositide class were identified and quantitatively estimated by combined thin-layer and gas-liquid chromatography of the component diglycerides, which were released by hydrolysis with a specific brain phosphodiesterase. The diglycerides were treated with pancreatic lipase, and the positional distribution of the fatty acids was determined. Over 27 molecular species were identified, and these accounted for about 95% of each phosphoinositide class, but the 1-stearate 2-arachidonate derivative contributed more than 40% of the total in each class. The other molecular species also were qualitatively and quantitatively similar in the three phosphoinositide classes. All the long-chain and polyunsaturated acids were confined to the 2-position and were preferentially paired with stearic acid in the 1-position. Oleic acid in the 2-position was about equally divided between species with palmitic and stearic acids in the 1-position. These results suggest that the mono-, di-, and triphosphoinositides of the bovine brain have similar compositions and that the various molecular species may be metabolically related. PMID- 4323397 TI - Simplified fluorometric method for the determination of plasma glycerol. AB - A simplified method for determining plasma glycerol is described. This assay utilizes the fluorometric measurement of the reduced adenine dinucleotide, NADH(2) which is formed when glycerol is oxidized by glycerol dehydrogenase. Only three pipettings are necessary for each reaction tube, and a large number of samples can be included in each assay. PMID- 4323398 TI - EB-virus antibodies in post-transfusion mononucleosis and cardiopulmonary bypass. PMID- 4323399 TI - Lienotoxicity of Bordetella pertussis in mice. PMID- 4323400 TI - Spin-labelled haemoglobins: a structural interpretation of electron paramagnetic resonance spectra based on X-ray analysis. PMID- 4323401 TI - Cytochrome oxidase activity in platelet-free preparations of Plasmodium falciparum. PMID- 4323402 TI - [Data furnished by continuous rheoencephalography in paradoxical sleep of the cat]. PMID- 4323403 TI - [Secretion of antidiuretic hormone during different types of aggression in the rat]. PMID- 4323404 TI - [Synergistic effect of the endogenous prolactin-nortestosterone combination on fructose and citric acid in the male accessory glands]. PMID- 4323405 TI - [Effects of sensory deafferentation on the wakefulness-sleep cycle]. PMID- 4323406 TI - [Sleep-wakefulness in white female rats during the circadian and estrus cycles]. PMID- 4323407 TI - [Demonstration of the liberation of dopamine (DA) and serotonin (5HT) at the caudate nucleus level in the rat]. PMID- 4323408 TI - [Adrenocortical activity during winter sleep in 2 hibernating animals: the dormouse (Eliomys quercinus L.) and the hodgehog (Erinaceus europaeus L.)]. PMID- 4323409 TI - Microphthalmia, prolactin and fertility in rats. PMID- 4323410 TI - Further immunological studies of aortitis syndrome. PMID- 4323411 TI - Some pathways and mechanisms in lanosterol-cholesterol conversion in mammalian tissues. PMID- 4323412 TI - Case studies of siblings with juxtaglomerular hyperplasia and secondary aldosteronism associated with severe azotemia and renal rickets--Bartter's syndrome or disease? PMID- 4323413 TI - [Use of a tissue culture vaccine in the prevention of small ruminant plague in Dahomey]. PMID- 4323414 TI - The histological relationship between "peste des petits ruminants" and kata in West Africa. PMID- 4323415 TI - Immunotherapy of cancer: regression of tumors after intralesional injection of living Mycobacterium bovis. AB - Injection of living Mycobacterium bovis (strain BCG) into established intradermal tumors caused tumor regression and prevented the development of metastases. PMID- 4323416 TI - [Changes in nocturnal sleep in parkinsonism patients treated with L-dopa]. PMID- 4323417 TI - [Septicemia--considerations on clinical findings and treatment]. PMID- 4323418 TI - [The effect of nembutal on afferent transmission in the thalamic somatosensory relay]. PMID- 4323419 TI - [The colinergic mechanisms of reticular inhibition of cerebral cortex neurons in the cat]. PMID- 4323420 TI - [Excretion of free 11-hydroxycorticosteroids in newborns and in childhood before and after ACTH administration]. PMID- 4323421 TI - Two unusual cases of mural endocarditis, with a review of the literature. PMID- 4323422 TI - Cystosarcoma phyllodes in a man with gynecomastia. PMID- 4323423 TI - Adenoid cystic carcinoma of the breast. PMID- 4323424 TI - Lipiodol accumulations simulating lung metastases as complication after lymphography. PMID- 4323426 TI - Portohepatography with an oily contrast medium. PMID- 4323425 TI - Roentgen features of giant cell carcinoma of the lung. PMID- 4323427 TI - Unusual retention of iodized oil. PMID- 4323428 TI - Roentgenographic features of multicentric carcinoma of the breast. PMID- 4323429 TI - A randomized study of hyperbaric oxygen as an adjunct to regularly fractionated radiation therapy for clinical treatment of advanced neoplastic disease. PMID- 4323430 TI - Muscarinic receptor sites in parasympathetic ganglia of the urinary bladder of the dog. PMID- 4323431 TI - Electron transport particles released upon lysis of spheroplasts of Escherichia coli B by Brij 58. PMID- 4323432 TI - Properties and function of the respiratory chain of freshwater mussel spermatozoa in relation to motility. PMID- 4323433 TI - [Study on the evolution of mitochondrial enzyme activities in hepatocyte during rat development]. PMID- 4323435 TI - Effects of substrate and substrate analogues on the trinitrophenylation of myosin. PMID- 4323434 TI - Oxidative phosphorylation coupled to oxygen uptake and nitrate reduction in Micrococcus denitrificans. PMID- 4323436 TI - Terminal oxidations in Bacillus brevis ATCC 10068. I. The measurement of the NADH oxidase activity of Bacillus brevis ATCC 10068. PMID- 4323437 TI - Effect of phenothiazines and their sulfoxides on lipoamide dehydrogenase. PMID- 4323438 TI - An ESR study of the light-induced interaction between porphyrins and quinones in amide solvents. PMID- 4323439 TI - Hypothalamic-pituitary-adrenal function in patients treated with long-term depot tetracosactrin. AB - Four patients treated with depot tetracosactrin for 10 to 18 months maintained normal hypothalamic-pituitary-adrenal function assessed by the nyctohemeral variation of plasma corticosteroids and by the responses of plasma corticosteroids to insulin-induced hypoglycaemia, lysine-vasopressin, and depot tetracosactrin. The pituitary component of the response was analysed by measuring plasma immunoreactive ACTH levels. Three patients showed a nyctohemeral ACTH rhythm and normal ACTH responses to insulin-induced hypoglycaemia. Consistently undetectable morning plasma ACTH levels were found in the fourth patient, who also showed an unusually delayed rise in both ACTH and corticosteroid levels in response to insulin-induced hypoglycaemia, though the peak values attained were normal.The lack of suppression of hypothalamic-pituitary-adrenal function together with the good clinical response in these four patients suggests that treatment with depot tetracosactrin should be considered when long-term corticosteroid therapy is required. PMID- 4323440 TI - [Orbital tumor in a child: case for histologic diagnosis]. PMID- 4323441 TI - [Role of the cell membrane in the control of cell division]. PMID- 4323442 TI - Hydroxylated vitamin D analogues. PMID- 4323444 TI - Enhanced resistance of mice to virulent Japanese B encephalitis virus following inactivated vaccine and poly I:C. PMID- 4323443 TI - Experimental respiratory infection with type 4 adenovirus vaccine in volunteers: clinical and immunological responses. PMID- 4323445 TI - Experimental alveolar lipo-proteinosis following the inhalation of silica. PMID- 4323446 TI - Degradation of granuloma-inducing micro-organisms by macrophages. PMID- 4323447 TI - The diagnosis of trophoblastic tumours from uterine curettings. PMID- 4323448 TI - Virological aspects of intra-uterine infection. PMID- 4323449 TI - Ultrastructure of hepatocellular carcinoma in non-human primates. PMID- 4323450 TI - Observations on an oncogenic herpes virus of primates. PMID- 4323451 TI - Transnodal remyelination. PMID- 4323453 TI - [Special nuclear inclusions in cells of cervical carcinoma]. PMID- 4323454 TI - [A case of malignant reticulohistiocytoma of the ovary]. PMID- 4323455 TI - Immunological studies on Burkitt lymphoma. PMID- 4323456 TI - Lanthanum ions abolish the "calcium response" of nerve terminals. PMID- 4323457 TI - Studies on the antiviral effect of rifampicin in volunteers. PMID- 4323458 TI - Increased transformation efficiency of Simian virus 40 in rat embryo cells infected with Rauscher leukaemia virus. PMID- 4323459 TI - Lymphoid cell lines: activation of a latent herpes-like virus particle? PMID- 4323461 TI - [Alpha-cell adenoma of the pancreas]. PMID- 4323460 TI - Cytoplasm from poliovirus-infected HeLa cells inhibits cell-free haemoglobin synthesis. PMID- 4323462 TI - [Oral tumors of the minor salivary gland--with special reference to adenocarcinoma]. PMID- 4323463 TI - [Enteroviruses in healthy children]. PMID- 4323465 TI - Nonphysical causes of dwarfism. PMID- 4323464 TI - [Changes in the occurrence of glomerulonephritis during the last 20 years]. PMID- 4323466 TI - Cylindroma of the trachea and left main bronchus. PMID- 4323467 TI - [The pathophysiologic mechanisms of neuro-allergic reactions in multiple sclerosis]. PMID- 4323468 TI - ["Slow" and "rapid" sleep in the structure of narcoleptic seizures]. PMID- 4323469 TI - [The phasic character of cortical neuron reactions and its functional significance for the transmission of excitation in afferent systems]. PMID- 4323470 TI - [Differences in the high frequency part of the electrocorticogram during physiologic sleep and wakefulness]. PMID- 4323471 TI - Pituitary adrenal axis evaluation in human scurvy. PMID- 4323472 TI - Effect of diet on hepatic fatty acid synthesis. PMID- 4323473 TI - Diabetes mellitus-like syndrome in mice infected with encephalomyocarditis virus. PMID- 4323476 TI - Transplacental production with ethylnitrosourea of neoplasms of the nervous system in Sprague-Dawley rats. PMID- 4323474 TI - Fine structural aspects of the mobilization of hepatic glycogen. I. Acceleration of glycogen breakdown. PMID- 4323475 TI - Fine structural aspects of the mobilization of hepatic glycogen. II. Inhibition of glycogen breakdown. PMID- 4323478 TI - Interference of Cysticercus fasciolaris in the formation of hepatic lesions in rats, induced by p-dimethylaminoazobenzene (DAB). PMID- 4323477 TI - Proliferation of microbodies and synthesis of catalase in rat liver. Induction in tumor-bearing host by CPIB. PMID- 4323479 TI - [Zollinger-Ellison syndrome]. PMID- 4323480 TI - Mixed tumor of the middle ear. A case report. PMID- 4323481 TI - Phospholipid distribution in erythrocyte and plasma of the man, cow, pig and rabbit. PMID- 4323482 TI - Action of diazoxide on skeletal muscle vascular resistance. PMID- 4323484 TI - Release of beta-glucuronidase as a quantitative assay of murine viral hepatitis injury in cultured cells. PMID- 4323483 TI - Converting enzyme activity in human plasma. PMID- 4323486 TI - Immunogenicity of synthetic angiotensin II octapeptide and analysis of antibodies by passive haemagglutination. PMID- 4323485 TI - Isotopic studies on the absorption and tissue distribution of white phosphorus in rats. PMID- 4323487 TI - Ultrastructural appearance of glycogen in neuron and astrocyte of the human cerebral cortex adjacent to brain tumors. PMID- 4323488 TI - Spectral sensitivity of the barnacle, Balanus amphitrite. AB - The extracellular ocellar potential was used to evaluate the spectral sensitivity of the ocellus of the barnacle, Balanus amphitrite. Maximum relative sensitivity was at 530-540 nm. Studies with chromatic adapting lights suggest that the receptors contain a single photopigment. The spectra were relatively broader in the dark as compared to the light-adapted state. This effect was shown to be due to an increase in the slope of the amplitude-intensity function, caused by light adaptation. Studies of tapetal fluorescence and corneal transmission indicate little effect of the ocellar media on the determination of sensitivity. PMID- 4323489 TI - Lymphoid necrosis in the mouse spleen produced by mouse hepatitis virus (MHV3): an electron-microscopic study. PMID- 4323490 TI - Antibody to oncogenic virus in cancer patients. PMID- 4323491 TI - [Vitamin P (vegetable polyphenol), its chemical nature and its mechanism of physiological action]. PMID- 4323492 TI - [Basic consideration on drug sensitivity of the circulatory system, with special reference to the venous system]. PMID- 4323493 TI - Effect of antibiotics on Tyzzer's disease. PMID- 4323495 TI - Cellular immunity induced by Rous sarcoma virus in Japanese quail. I. Effect of anti-lymphocyte serum on oncogenesis of Rous sarcoma virus. PMID- 4323494 TI - The growth kinetics of an attenuated poliovirus type 1 strain, LSc, 2ab at an elevated temperature. PMID- 4323496 TI - [Electroencephalograms in ruminants. 1. EEG of goats]. PMID- 4323497 TI - [Antibiotic-corticoid combination: Stapolidex pommade]. PMID- 4323498 TI - Crayfish interneurons. PMID- 4323499 TI - Gliosarcomas. PMID- 4323500 TI - [Adult toxoplasmosis. Considerations on a case with associated bilateral brachial plexitis]. PMID- 4323501 TI - [Study of the enzyme activity of the synovial fluid (phosphatases, transaminases, aldolase)]. PMID- 4323502 TI - [Problems in the after care of children with tumors]. PMID- 4323503 TI - [Method of radioisotope scintophotography in the diagnosis of brain diseases]. PMID- 4323504 TI - [Function of thassociative nuclei of the thalamus (clinico-anatomical studies)]. PMID- 4323506 TI - Factors influencing the transfer of col E and col I. PMID- 4323505 TI - Thyroid stimulators and thyroid stimulation. PMID- 4323507 TI - [Inhibitors of the mobilization of free fatty acids]. PMID- 4323508 TI - Social linkability. PMID- 4323509 TI - The effect of magnesium sulfate on anoxia and resuscitation in the neonate. PMID- 4323511 TI - Clostridium perfringens food poisoning. PMID- 4323510 TI - The determination of adrenal steroids by gas chromatography and its application to clinical research. PMID- 4323513 TI - An apparatus for producing small-amplitude high-frequency sinusoidal stretching of the muscle. PMID- 4323512 TI - [Effect of bactericidal concentrations of chemotherapeutic compounds on El-Tor and the classical cholera vibrios depending on the time of contact and the inoculation dose]. PMID- 4323514 TI - Partial purification and properties of a K plus-and minus and Mg2-plus or minus dependent phosphodiesterase from Salmonella typhimurium. PMID- 4323515 TI - Light-induced reduction of pyridine nucleotide and its relation to light-induced electron transport in whole cells of Rhodospirillum rubrum. PMID- 4323516 TI - Photosynthesis of isolated chloroplasts. V. Effect of fixation rate and metabolite transport from the chloroplasts caused by added fructose-I,6 diphosphatase. PMID- 4323518 TI - Enzymatic alkylation of menaquinone-o to menaquinones microsomes from chick liver. PMID- 4323517 TI - [Fractionation and purification of cytpplasmic membrane and mesosome systeme of Bacillus subtilis. Study of some of their redox properties associated with the respiratory chain]. PMID- 4323519 TI - The effect of carnitine and CoA on ketogenesis and citric acid cycle activity during long-chain fatty acid oxidation by isolated rat liver mitochondria. PMID- 4323520 TI - [Immunological variability in the type of aphthous virus, its limits and practical significance]. PMID- 4323521 TI - [New developments in the Frenkel method. Results obtained]. PMID- 4323522 TI - [Studies of the action of a new anti-aphthous vaccine in swine]. PMID- 4323523 TI - Improvement of foot-and-mouth disease vaccine of Frenkel origin with the study of the immunogen virus component made evident by arcton extraction. PMID- 4323524 TI - Basis of the preparation of A22 type foot-and-mouth disease vaccine in Turkey. PMID- 4323525 TI - [Attempted vaccination of swine with inactive aphthous virus vaccines. I. Tests of O virus inactivated with hydroxylamine, formol, heat and pH]. PMID- 4323526 TI - [Correaation between the sero-neutralization test in mice and crossed anti aphthous immunization in cattle]. PMID- 4323527 TI - [Preparation and testing of an anti-aphthous vaccine with A22 virus cultured in tissue cultures]. PMID- 4323528 TI - [Verification of a method of standardization of the antigens of anti-aphthous vaccine based on complement fixation capacity]. PMID- 4323529 TI - [The problem of the relations between the test of protection in cattle and the index of protection in mice in the checking of the effectiveness of anti-aphthous vaccines prepared with cultured virus]. PMID- 4323530 TI - [Anti-aphthous vaccination of sheep]. PMID- 4323531 TI - [Checking of the immunity produced in a district by triple trivalent vaccination]. PMID- 4323532 TI - Immunologic relationships between O Lausanne and Turkish O. PMID- 4323534 TI - Effect of antilipolytic compounds on cyclic 3',5'-adenosine monophosphate activation of adipose tissue lipolysis. PMID- 4323533 TI - [Studies of sero-neutralization in mice used for measurement of post-vaccination immunity of cattle to foot-and-mouth disease]. PMID- 4323535 TI - [The biochemistry of mental disorders]. PMID- 4323536 TI - Pathologic physiology and chemotherapy of Plasmodium berghei. IX. Gastric secretion and the influence of 1-aminocyclopentane carboxylic acid (WR 14, 997 or cycloleucine). PMID- 4323537 TI - Actinomycin D inhibition of intestinal transport of L-histidine and of vitamin D action. PMID- 4323538 TI - Enzymatic phosphorylation of protein of rat liver chromatin by (gamma-32P) ATP in vitro. PMID- 4323539 TI - Effect of succinate administered in combination with progesterone, chlorpromazine and chloramphenicol on the stability of liver lysosomes of rats fed on different diets. PMID- 4323540 TI - Renal pressor activity and kidney weight responding to angiotensin in hypertensive ras. PMID- 4323541 TI - Plasma angiotensin, serum 'angiotensinase activity', and blood pressure response during angiotensin II amide infusions in normal volunteers. PMID- 4323542 TI - Genetic control of rye endosperm proteins. PMID- 4323543 TI - Drug therapy of resistant cases of pulmonary tuberculosis in Indian patients. PMID- 4323544 TI - Experimental studies on entamoeba histolytica with special reference to asymptomatic cyst passers. PMID- 4323545 TI - Deaths of institutionaiized children with intractable asthma. Report of three cases with necropsies. PMID- 4323546 TI - Immunological studies with simian virus 40 (SVp0) tumors in hamsters. Effect of xenogenic cells in allogeneic transplantation immunity. PMID- 4323547 TI - Granular cell myoblastoma of the bronchus. Report of a case with treatment by upper lobectomy and sleeve resection of the stem bronchus. PMID- 4323549 TI - RNA dependent DNA polymerase in primate syncytium-forming (foamy) viruses. PMID- 4323548 TI - A clinical approach to the hyperlipidemias. PMID- 4323550 TI - Concentrations of plasma testosterone in normal men during sleep. PMID- 4323552 TI - Molecular models. PMID- 4323553 TI - Nonsense fragments. PMID- 4323551 TI - Stimulation of intestinal adenyl cyclase by cholera toxin. PMID- 4323554 TI - [Current problems of viral neuroinfections]. PMID- 4323555 TI - Resection of superior mesenteric vessels in pancreatectomy. PMID- 4323556 TI - [Role of prostaglandins in the pathogenesis of arterial hypertension]. PMID- 4323557 TI - [Adrenocortical insufficiency and hyperthyroidism]. PMID- 4323558 TI - [Secreting islet cell tumor]. PMID- 4323559 TI - [Cristalline coxopathies resembling infection]. PMID- 4323561 TI - [Cauda equina syndrome of diskal origin in rheumatologic practice]. PMID- 4323560 TI - [Uric acid inhibitors in the treatment of gout. Apropos of 126 cases]. PMID- 4323562 TI - [Melitococcal sacro-ileitis]. PMID- 4323563 TI - [Current problems in the treatment of heart failure]. PMID- 4323564 TI - Soft tissue sarcomas involving the extremities and the limb girdles: a review. PMID- 4323565 TI - Nerve conduction studies: an aid in the diagnosis of the thoracic outlet syndrome. PMID- 4323566 TI - Extreme elevation in total serum bilirubin: a study of the causes in 32 consecutive cases. PMID- 4323567 TI - [Herpes simplex infections]. PMID- 4323568 TI - Some properties of polyoma virus "T" and "tumour" antigens. PMID- 4323569 TI - [Studies on the secretion of the cardiac gland zone in the pig stomach. II. Studies on the influencing of spontaneous secretion of the isolated cardiac gland zone, fluid and electrolyte secretion in the isolated small stomach containing different fluids]. PMID- 4323570 TI - [Circulation of pertussis bacteria of different serological types in some districts of the USSR]. PMID- 4323571 TI - [Isolation and certain properties of a protective antigen from B. pertussis]. PMID- 4323572 TI - Radiotherapy of intracerebral astrocytomas. PMID- 4323573 TI - Topography of lymph drainage from mammary gland and hand to axillary lymph nodes. PMID- 4323575 TI - [Investigations on a p-aminobenzoic auxotrophic mutant of Chlamydomonas reinhardii: chloramphenicol as a substitute for p-aminobenzoic-acid]. PMID- 4323574 TI - [Acetaldehyde as an indicator for the regulation of respiration and fermentation during aerobic fermentation of glucose by Saccharomyces cerevisiae]. PMID- 4323576 TI - [Metabolic products of microorganisms. 87. L-2,5-Dihydrophenylalanine]. PMID- 4323577 TI - Action of venom phosphodiesterase on transfer RNA from Escherichia coli. PMID- 4323578 TI - Interferon induction by and infectivity of ultraviolet-irradiated double- and multistranded viral RNA's. PMID- 4323580 TI - Conformational changes of nucleic acids in methanol-water solutions at low temperature. PMID- 4323579 TI - Rous sarcoma virus-induced changes in uridine and UMP metabolism in chick chorioallantoic membrane. PMID- 4323581 TI - Some properties of an alkaline deoxyribonuclease from regenerating rat liver. PMID- 4323582 TI - [Experience with pyelonephritis during past 10 years]. PMID- 4323583 TI - [Radioimmunoassay of human growth hormone by enzyme proteolysis]. PMID- 4323584 TI - The release of periplasmic phosphoesterases from Vibrio cholerae and Vibrio eltor. PMID- 4323585 TI - Nature of cell injury induced by murine hepatitis virus (MHV3). PMID- 4323586 TI - A new microbial metabolite, sphydrofuran. I. Isolation and the structure of a hydrolysis product. PMID- 4323587 TI - Further studies on mammalian cell strains transformed by avian sarcoma viruses. PMID- 4323588 TI - Histologic and cytogenetic observations on a case of giant fibroadenoma. PMID- 4323590 TI - A surgical approach to subungual glomus tumors. PMID- 4323589 TI - A morphological and histochemical study of Trichuris suis (Schrank, 1788) with special reference to the host-parasite relationship. PMID- 4323591 TI - Hormonal effects on extracellular cyclic nucleotides in man. PMID- 4323592 TI - A mechanism for cartilage destruction in rheumatoid arthritis. PMID- 4323593 TI - How to weigh and elephant: cytochrome oxidase as a rate-governing step in mitochondrial oxygen consumption. PMID- 4323594 TI - Recognition of foreignness in invertebrates. Transplantation studies using the American cockroach (Periplaneta americana). PMID- 4323595 TI - [Stimulating interaction of animal viruses]. PMID- 4323596 TI - [The effect of poliomyelitis virus infection on the matrix activity of FL cell deoxyribonucleoprotein in in vitro experiments with E. coli RNA-polymerase]. PMID- 4323597 TI - [Isolation of arboviruses from Ixodes (Ceratixodes) putus Pick-Cambr. ticks collected in a bird colony on the island of Tiulenii in the Sea of Okhotsk]. PMID- 4323598 TI - [Use of human thyroid gland cell cultures for virologic studies]. PMID- 4323599 TI - [Characteristics of viral RNA isolated from the polyribosomes of infected cells]. PMID- 4323600 TI - [Thermoinactivation of viruses. I. The relationship between the speed of inactivation and temperature]. PMID- 4323601 TI - [Demonstration of virus-like particles in the serum of monkeys withexperimentally induced infectious hepatitis. Preliminary report]. PMID- 4323603 TI - "Mood drug" advertisers to comply with broadcasters' code. PMID- 4323602 TI - [Anaphylactic and cyergic reactions of delayed-type hypersensitivity in IBR-IPV immune cattle]. PMID- 4323604 TI - "Home from hospital". PMID- 4323605 TI - [Malabsorption syndrome in the light of present-day knowledge]. PMID- 4323606 TI - [Mixed tumor or pleomorphic adenoma of the cheek]. PMID- 4323607 TI - [Staphylococcus aureus--evaluation of tests for its identification. Differences in the biochemical action in human and animal strains]. PMID- 4323608 TI - [Effect of chemical mediators of nervous regulation on the gastro-duodenal electric activity in dogs]. PMID- 4323609 TI - Metaboism of 25-hydroxycholecalciferol in target and nontarget tissues. PMID- 4323611 TI - Interaction of cytochrome c and the phosphoprotein phosvitin. Formation of a complex with an intact 695-mmicron absorption band. PMID- 4323610 TI - Electron transport reversal and teroid 11-beta hydroxylation in adrenal corticl mitochondria. PMID- 4323613 TI - Histiocytic medullary reticulosis associated with cytomegalic inclusion disease. A case report. PMID- 4323612 TI - Magnetic resonance and kinetic studie of the activation of beta-methylaspartase by manganese. PMID- 4323614 TI - Ultrastructural observations on a gingival granular cell tumor (congenital epulis). PMID- 4323615 TI - Carcinoid tumor of the vermiform appendix with cushing's syndrome. Ultrastructural study of a case. PMID- 4323616 TI - Benign clear cell tumor ("sugar tumor") of the lung. PMID- 4323617 TI - [Studies on the alkaline phosphatase of meningiomas]. PMID- 4323620 TI - Collagenase. Its effectiveness as a dispersing agent for embryonic chick thyroid and heart. PMID- 4323618 TI - Pathogenesis of redistribution of intrarenal blood flow in haemorrhagic hypotension. PMID- 4323621 TI - [Nephroblastoma in childhood: current possibilities for an early radiographic diagnosis]. PMID- 4323622 TI - [Current trends on histogenesis of early childhood nephroblastomas]. PMID- 4323624 TI - [ESR studies on hydroxyl radical reactions with glycine]. PMID- 4323623 TI - [Experimental determination of the maximum permissible concentration of lead silicate in the air of industrial premises]. PMID- 4323625 TI - [NAD permeation into the liver cell]. PMID- 4323626 TI - [Studies on the lipid dependability of NADH: semidehydroascorbinic-acid oxidoreductase (EC 1.6.5.4)]. PMID- 4323627 TI - Acute toxic effects of chloroquine on the cat retina: ultrastructural changes. PMID- 4323628 TI - Catlysis of the phosphrylaseinase actition reaction. PMID- 4323629 TI - Theory of flicker and transient responses. II. Counterphase gratings. PMID- 4323630 TI - Susceptibility to superinfection of hybrids between polyoma "transformed" BHK and "normal" 3T3 cells. PMID- 4323631 TI - Potentiation of the antiviral activity of interferon by actinomycin D. PMID- 4323632 TI - Effect of interferon on some aspects of transformation by polyoma virus. PMID- 4323633 TI - Structure of aspartate-tRNA from brewer's yeast. PMID- 4323634 TI - [Considerations on glycogenosis, type 3]. PMID- 4323635 TI - Glycine reabsorption in rat proximal tubules. Microperfusion studies. PMID- 4323636 TI - [A procedure for the simultaneous determination of glucose, lactate and pyruvate concentrations in micro blood samples]. PMID- 4323637 TI - Size distribution of lymph cells. PMID- 4323638 TI - [Evaluation of cerebrospinal fluid pressure levels]. PMID- 4323639 TI - On the mechanism of the degradation of nucleic acids by periodate oxidation. PMID- 4323640 TI - Anaerobic transformation of steroids by Mycobacterium phlei. PMID- 4323641 TI - Studies on swine enteroviruses. 3. Occurrence of enteroviruses in Hungarian swine herds and in the kidney tissue of normal pigs. PMID- 4323643 TI - [Experimental rat tumors induced with administration of nitrosourea derivatives. II. Observations on the sterol composition]. PMID- 4323642 TI - [Experimental rat tumors induced with administration of nitrosourea derivatives. I. Morphological and histochemical observations]. PMID- 4323645 TI - Transport of herpes simplex virus in peripheral nerves. PMID- 4323644 TI - [Progressive multifocal leukoencephalopathy. Histopathology and ultrastructure]. PMID- 4323646 TI - Movement of mitochondria within constricted noradrenergic axons. PMID- 4323653 TI - Intracisternal granules in the human pancreas. PMID- 4323647 TI - Optimal combination and concentration of antibiotics in media for isolation of pathogenic fungi and Nocardia asteroides. AB - Strains of Blastomyces dermatitidis, Sporothrix schenckii, Histoplasma capsulatum, Cryptococcus neoformans, Nocardia asteroides, and Coccidioides immitis were tested for in vitro susceptibility to polymyxin, gentamicin, kanamycin, chloramphenicol, and neomycin at concentrations of 1, 2, 4, 8, and 16 mug/ml. Polymyxin was the most inhibitory and gentamicin was the least inhibitory of the five antibiotics. Two Histoplasma mycelial strains were partially inhibited by 2 and 8 mug of gentamicin per ml and showed at least a 2+ growth at the higher antibiotic concentration. Kanamycin and neomycin produced significant inhibition of N. asteroides but otherwise were noninhibitory. A combination of chloramphenicol and kanamycin, each at 16 mug/ml, and gentamicin, at 4 mug/ml, was noninhibitory to the strains tested except for N. asteroides. Chloramphenicol at 16 mug/ml was not inhibitory for N. asteroides. The results suggest that the optimal antibiotic combination to use in the isolation of fungi and higher bacteria is chloramphenicol, 16 mug/ml, and gentamicin, 4 mug/ml. Addition of sheep blood (5%) had no effect on antibiotic susceptibility of the organisms studied. PMID- 4323654 TI - Inhibition of the mitochondrial respiratory chain in isolated atria--a comparison of rotenone and amytal. PMID- 4323655 TI - The mode of action of hydrocortisone on the protein metabolism in rat carrageenin granuloma. PMID- 4323656 TI - Effect of phalloidin on Mg2+-ATPase, (K+-Na+)-ATPase and K+-dependent p nitrophenyl phosphatase activity of plasma membranes isolated from rat liver. PMID- 4323657 TI - Enhancement of vasopressin-induced water loss in toad bladder by certain phospholipids. PMID- 4323658 TI - Morphine and the incorporation of 32-orthophosphate in vivo into phospholipids of the guinea pig cerebral cortex, liver and subcellular fractions. PMID- 4323659 TI - Effects of hydroxamic acids on L-histidine carboxy-lyase. PMID- 4323660 TI - Preparation and properties of iodinated angiotensins. PMID- 4323661 TI - Inhibition of 3'5'-cyclic-AMP phosphodiesterase by some platelet aggregation inhibitors. PMID- 4323662 TI - [Effects of catecholamines and several phenylethylamines and their precursors on gluconeogenesis in homogenate supernatants of the liver and the kidney of the rat, containing the microsomal fraction]. PMID- 4323663 TI - [Intervention of the glycerophosphate cycle in glycolysis regulation of normal liver tissue or on the cancerization process in the rat]. PMID- 4323664 TI - The electron paramagnetic resonance spectrum at 77 degrees K of lyophilized and frozen solutions of horse heart ferricytochrome c. PMID- 4323665 TI - Sodium-potassium stimulated adenosinetriphosphatase of vascular smooth muscle. PMID- 4323667 TI - [Effect of simultaneous continuous exposure to low frequency vibration and noise on the functional status of the pituitary-adrenal cortex system]. PMID- 4323666 TI - Electrographic reactivity to caloric vestibular stimulation in cerebral circulatory disturbances. PMID- 4323668 TI - Effects of catecholamines on the neuromuscular junction of the somatic muscle of the earthworm Pheretima communissima. PMID- 4323669 TI - [Place of a delayed-action tetracosactide (synthetic cortico-stimulant) in treatment of obstructive bronchopathy]. PMID- 4323670 TI - Radiographic determination of the skeletal age of the young swimmers. PMID- 4323671 TI - Two-and-one-half-year survival of patient with ruptured Wilms' tumor. PMID- 4323672 TI - Epistaxis in a teen-age boy. PMID- 4323673 TI - The Guillain-Barre syndrome and multiple sclerosis. In vitro cellular responses to nervous-tissue antigens. PMID- 4323674 TI - Inactivation of angiotensin II by rat kidney homogenates. PMID- 4323675 TI - [Diagnosing alveolar cancer of the lungs]. PMID- 4323676 TI - [Scintiphotography with the gamma camera in diagnosis of intracranial lesions]. PMID- 4323677 TI - [In vitro replacement of human erythrocyte phospholipids by means of incorporation of inorganic phosphorus 32]. PMID- 4323678 TI - [Diagnosis of skin neoplasms using P 32]. PMID- 4323679 TI - [Glycogen and endoplasmic reticulum of the liver cell after high doses of the carcinogen N-nitrosomorpholin]. PMID- 4323680 TI - Hepatic ultrastructure in mucolipidosis I (lipomucopolysaccharidosis). PMID- 4323681 TI - Hepatic ultrastructure in fucosidosis. PMID- 4323682 TI - [Virus induced RNA in the polyribosomes of Ehrlich ascites carcinoma cells infected with Sendai virus]. PMID- 4323684 TI - [Thermoinactivation of viruses. II. The nature of anomalies in the inactivation of viruses]. PMID- 4323683 TI - [Isolation of a new antigen induced by Sendai virus]. PMID- 4323685 TI - [Non-specific defense reactions in the central nervous system following antirabies vaccination]. PMID- 4323686 TI - [The immunodepressive effect of DNA-containing viruses: papovavirus SV40 and human adenovirus type 16]. PMID- 4323687 TI - Rapid eye movements during the paradoxical sleep of rabbits. PMID- 4323688 TI - Experimental disc lesion in rabbits. The effect of repeated ACTH administration. PMID- 4323689 TI - Islet cell tumor with hypoglycemia. PMID- 4323690 TI - Colloid carcinoma of the breast. PMID- 4323691 TI - Community care and the "Queequeg syndrome": a phenomenological evaluation of methods of rehabilitation for psychotic patients. PMID- 4323692 TI - [A rapid method for the preparation of highly purified transforming DNA]. PMID- 4323693 TI - Enzymatic methylation of transfer RNA by extracts of polyoma virus-transformed cells. PMID- 4323694 TI - A low potential photosystem in Chromatium D. PMID- 4323695 TI - An improved method for the large-scale isolation of chromaffin granules from bovine adrenal medulla. PMID- 4323697 TI - Tightly bound cardiolipin in cytochrome oxidase. PMID- 4323696 TI - [Investigation of the penetration of oxaloacetate into rat liver mitochondria]. PMID- 4323698 TI - Electron carriers of the bovine adrenal chromaffin granules. PMID- 4323700 TI - [Experiences of the chorionepithelioma research center and prospects of further research activity]. PMID- 4323699 TI - [Effects of various ribonucleic acids (RNA) on the activity of deoxyribonucleic acid polymerase (DNA-polymerase) associated with an oncogenic ribovirus]. PMID- 4323701 TI - [Age peculiarities in electric pulsation of aortic and sinus nerves]. PMID- 4323702 TI - [Several physico-chemical properties of manganese ore and quartz dust]. PMID- 4323703 TI - [Effect of DDT and sevin on several liver enzymes]. PMID- 4323704 TI - [Effect of small doses of copper, manganese and zinc on the animal organism]. PMID- 4323705 TI - Problems in leukemia etiology. PMID- 4323706 TI - Choline acetyltransferase and acetylcholinesterase in cultured brain cells from chick embryos. PMID- 4323707 TI - Microassay of adenosine-3',5'-monophosphate (cyclic AMP) in brain and other tissues by the luciferin-luciferase system. PMID- 4323708 TI - Effects of denervation on the incorporation of 32P into phosphatidyl inositol and other phospholipids of rat diaphragm. PMID- 4323710 TI - Studies of nondefective adenovirus 2-simian virus 40 hybrid viruses. 3. Base composition, molecular weight, and conformation of the Ad2+ND genome. AB - The nondefective adenovirus 2 (Ad2)-simian virus 40 (SV40) hybrid virus, Ad2(+)ND(1), differs from the defective Ad-SV40 hybrid populations previously described, in that this hybrid virus can replicate without the aid of nonhybrid adenovirus helper. Consequently, the deoxyribonucleic acid (DNA) from this virus, which can be obtained free of nonhybrid adenovirus DNA, is well suited for biophysical studies on Ad-SV40 hybrid DNA. Such studies have been performed and demonstrate Ad2(+)ND(1) DNA to have a buoyant density (1.715 g/cm(3)) and thermal denaturation profile (T(m) = 75.1 C) almost identical with nonhybrid Ad2 DNA. Furthermore, its molecular weight, as determined by analytical zone sedimentation and electron microscopy, was 22 x 10(6) to 25 x 10(6) daltons, which is also very similar to that determined for Ad2. Electron micrographs showed all of the hybrid molecules to be double-stranded and linear. By using this determination of the molecular weight of Ad2(+)ND(1) DNA and assuming that 1% of this molecule consists of covalently linked SV40 DNA (see companion paper), we calculate that the hybrid DNA molecule contains 220 x 10(3) to 250 x 10(3) daltons of SV40 DNA, or the equivalent of one-tenth of the SV40 genome. PMID- 4323709 TI - Studies of nondefective adenovirus 2-simian virus 40 hybrid viruses. II. Relationship of adenovirus 2 deoxyribonucleic acid and simian virus 40 deoxyribonucleic acid in the Ad2+ND genome. AB - A nondefective adenovirus 2 (Ad2)-simian virus 40 (SV40) hybrid virus, Ad2(+)ND(1), has been plaque-isolated from an Ad2-SV40 hybrid population. This virus, unlike the defective Ad-SV40 hybrid populations previously described, replicates without the aid of nonhybrid adenovirus helper. Consequently, the hybrid virus deoxyribonucleic acid (DNA) can be obtained free of nonhybrid adenovirus DNA. The DNA of the Ad2(+)ND(1) virus was shown by ribonucleic acid (RNA)-DNA hybridization to consist of nucleotide sequences complementary to Ad2- and SV40-specific RNA. Techniques of equilibrium density and rate zonal centrifugation were employed to demonstrate that these Ad2 and SV40 nucleotide sequences were linked together in the same DNA molecules by alkali-resistant bonds. Calibration curves were established relating the amount of tritium-labeled SV40-specific RNA (prepared in vitro or in vivo) bound to given amounts of SV40 DNA in a hybridization reaction, and these curves were employed to determine the equivalent amount of SV40 DNA in the Ad2(+)ND(1) molecule. From the results obtained, it was estimated that 1% of the Ad2(+)ND(1) DNA consists of SV40 nucleotide sequences. PMID- 4323711 TI - Structure and biological activity of deoxyribonucleic acid from Bacillus bacteriophage phi 105: effects of Escherichia coli exonucleases. AB - The effects of Escherichia coli exonuclease I, exonuclease III, and deoxyribonucleic acid (DNA) polymerase on the biological activity of mature DNA from temperate Bacillus bacteriophage phi105 were investigated. Intact DNA loses infectivity rapidly upon exposure to exonuclease III. Although there is an overall decrease in marker rescue from exonuclease III-digested DNA, digestion preferentially affects markers at the end of the genetic map. This is taken to indicate a nonpermuted gene sequence in mature DNA. Incubation of mature DNA in the presence of exonuclease I or DNA polymerase has no effect on its biological activity. The possible structure of the ends of mature phi105 DNA is discussed. The rate of digestion of mature phi105 DNA by exonuclease III is only about 1/20 the rate of lambda DNA. Results of digestion of various DNA substrates by exonuclease III indicate that the enzyme distinguishes between different DNA terminal structures. PMID- 4323712 TI - Ribonucleic acid polymerase in virions of Newcastle disease virus: comparison with the vesicular stomatitis virus polymerase. AB - The virions of Newcastle disease virus (NDV) contained an enzyme that catalyzed the incorporation of ribonucleotides into ribonucleic acid (RNA). Optimal conditions for this polymerase activity were identical to the conditions for the vesicular stomatitis virus (VSV) polymerase, and both enzymes were active for longer times at 32 C than at 37 C. However, the specific activity of the NDV polymerase was less than 3% that of the VSV polymerase. Product RNA species from the NDV and VSV polymerase reactions annealed specifically to the homologous virion RNA species. Transcriptive intermediates containing product RNA attached to the respective virion RNA could be identified in both systems. PMID- 4323713 TI - Absence of interference during high-multiplicity infection by clonally purified vesicular stomatitis virus. AB - Stocks of vesicular stomatitis virus free of defective interfering particles were produced by serial clonal isolation. High-multiplicity infections with these stocks led to no interference or formation of defective interfering particles. Defective interfering particles were generated by three successive passages at high multiplicity. PMID- 4323714 TI - Carbohydrate composition of vesicular stomatitis virus. AB - Analysis by gas-liquid chromatography of the trimethylsilylated sugar residues of purified vesicular stomatitis virus grown in L cells or chick embryo cells revealed the presence in the whole virion of four hexoses (glucose, galactose, mannose, and fucose), two hexosamines (glucosamine and galactosamine), and 34 to 40% neuraminic acid. The isolated viral glycoprotein was devoid of galactosamine and fucose, both of which sugars were present in whole virions presumably as part of the membrane glycolipids. PMID- 4323715 TI - Glycolipid content of vesicular stomatitis virus grown in baby hamster kidney cells. AB - Vesicular stomatitis virions grown in baby hamster kidney (BHK-21-F) cells were found to contain hematoside (neuraminosyl-galactosyl-glucosyl-ceramide). This ganglioside, which was the only detectable glycolipid in the virion, is also the only glycolipid found in significant amount in BHK-21-F cells. Approximately 87% of the total neuraminic acid in the virion was found to be linked to protein and 13% to lipid. PMID- 4323716 TI - [Problems of oil contrast media lymphography in children and adolescents]. PMID- 4323717 TI - [Proposal for a consequent night therapy of psychiatric patients--also a contribution to a day-night therapy of depressions using psychopharmaca]. PMID- 4323718 TI - [Antraquinone derivatives. XXI. Formation of free radicals by dianthrones]. PMID- 4323719 TI - [Effect of different postoperative periods on neuromuscular irritation and accommodation]. PMID- 4323720 TI - Automated enzymic method for the determination of glycerol. PMID- 4323721 TI - New assay for ATP-sulphurylase using the luciferin-luciferase method. PMID- 4323722 TI - Correlation between separation of low molecular weight RNA on MAK columns and polyacrylamide gels. PMID- 4323723 TI - [Treatment of various neurological disorders. Treatment of childhood epilepsy]. PMID- 4323724 TI - Specificity of lipids and coenzyme Q in mitochondrial NADH and succin-oxidase of beef heart and S. cerevisiae. PMID- 4323725 TI - Purification and kinetic studies of adenine phosphoribosyltransferase from human erythrocytes. PMID- 4323726 TI - The effects of bound anions on the reactivity of residues in hemerythrin. PMID- 4323727 TI - The effects of acid-base ionization of hemerythrin on its ligand coordination equilibria. PMID- 4323729 TI - A particulate fraction from Neurospora crassa exhibiting aryl sulfatase activity. PMID- 4323728 TI - Human plasma converting enzyme. PMID- 4323730 TI - Energy-linked swelling of biotin-deficient rat liver mitochondria. PMID- 4323731 TI - The effect of nucleotides and a nondialyzable factor on the hydrolysis of cyclic AMP by a cyclic nucleotide phosphodiesterase from beef heart. PMID- 4323732 TI - The silylation of human enamel and dentine and its effect on acid dissolution. PMID- 4323733 TI - [Transmission of frequent series of impulses in demyelinated and degenerating nerve fibres]. PMID- 4323735 TI - [Some cases of viral associations encountered in human samples]. PMID- 4323734 TI - [New viewpoints on the problem of the origin and pathogenetic significance of inflammatory reaction in viral infections of the CNS. Immunofluorescence, morphological and virological studies on the model of experimental poliomyelitis]. PMID- 4323736 TI - [Surgery in hyperinsulinism]. PMID- 4323737 TI - [Surgical and conservative treatment of hyperinsulinism]. PMID- 4323738 TI - [Clinical syndromes of hormonally active pancreatic tumors]. PMID- 4323739 TI - ACTH-induced adrenocortical response patterns in multiple sclerosis and their relation to the clinical effectiveness of ACTH therapy. PMID- 4323740 TI - The electromyographic changes by antibiotics. A preliminary study. PMID- 4323741 TI - [Action potential generation by frog tectum opticum dendrites]. PMID- 4323742 TI - [Comparison of the characteristics of 99m-Tc-pertechnetate and 113m-In-EDTA in brain scintigraphy]. PMID- 4323743 TI - [Angiographic and scintigraphic findings in a benign cystic cholangioma of the liver]. PMID- 4323744 TI - [On an atypical case of median nerve compression in the carpal canal]. PMID- 4323745 TI - Mechanism of presqualene pyrophosphate-squalene biosynthesis. PMID- 4323746 TI - Studies on the mechanism of squalene biosynthesis. Presqualene pyrophosphate, stereochemistry and a mechanism for its conversion to squalene. PMID- 4323747 TI - A plaque assay for enumerating antigen-sensitive cells in delayed-type hypersensitivity. AB - A general method is described for enumerating antigen-sensitive lymphocytes obtained from individuals having delayed hypersensitivity, in this case from highly tuberculin-sensitive guinea pigs. The method is based on the observation that resting lymphocytes are generally unable to support replication of RNA viruses, whereas antigen-"activated" lymphocytes can. Lymph node lymphocytes from individual animals were cultured in the presence or absence of tuberculin purified protein derivatives (PPD). After various periods of time, the cells were infected either with Newcastle disease virus or vesicular stomatitis virus, and plated in agar over a monolayer of cells susceptible to the virus. Wherever a lymphocyte yielded infectious virus, a discrete plaque in the monolayer could be seen. The increase in plaques of the antigen-stimulated cells over the background of the control sample was taken as the number of antigen-sensitive cells in the population. When lymphocytes from normal guinea pigs or from guinea pigs immunized to produce only circulating antibody to PPD were similarly tested, no increase in plaque-forming units (PFU) was observed. The average increase in PFU due to antigenic stimulation varied from 1 per 1000 lymphocytes at 24 hr to 16 per 1000 lymphocytes at 96 hr. By employing inhibitors of mitosis (colchicine, vinblastine, and thymidine) it was evident that the increase in PFU at least up to 48 hr was primarily due to initial antigen-reactive cells and not their progeny. PMID- 4323749 TI - [Electron microscopic study of a peripheral nerve in a case of Krabbe's leukodystrophy]. PMID- 4323750 TI - The ultrastructural appearance of astrocytes following thermal lesions of the rat cortex. PMID- 4323748 TI - The effect of induced chronic viral infections on the immunologic diseases of New Zealand mice. AB - Chronic infections induced at birth with either LCM, an RNA virus, or polyoma, a DNA virus, in NZB, NZW, and NZB x W mice enhance ANA formation, aggravate the immune complex glomerulonephritis, and increase the associated mortality. The ANA titer was increased without apparent change in specificity of the antibodies involved in all three types of mice. Glomerulonephritis, while more severe in infected mice, was of the same type as occurred spontaneously and was characterized by a granular to lumpy accumulation of host IgG and C3 in the mesangia and along the capillary walls of the glomeruli. Of the LCM infected mice of all three types over 50% had died of glomerulonephritis by 6 months and over 85% by 9 months. Of the polyoma infected mice of all three types approximately 20% had died of glomerulonephritis by 6 months and over 40% by 9 months. Of the uninfected controls of all three types less than 10% had died by 6 months and less than 20% at 9 months except for the NZB x W females which had a 67% mortality at 9 months as a result of their spontaneous glomerulonephritis. The two viral infections had significant effect on the incidence of anti-red cell antibodies or the severity of autoimmune hemolytic anemia in any of the three NZ mice. PMID- 4323751 TI - The structure of viomycidine. PMID- 4323752 TI - [Wilms' tumors]. PMID- 4323753 TI - Poliomyelitis--still with us. PMID- 4323754 TI - [Primary liver carcinoma and polyglobulia]. PMID- 4323755 TI - [Photometric determination of several fat-soluble vitamins (A,D3,K3) in the presence of each other]. PMID- 4323757 TI - Salting the transduction tale. PMID- 4323756 TI - Respiration deficient mutants of Schizosaccharomyces Pombe I. PMID- 4323758 TI - 5'-terminus of influenza virus RNA. PMID- 4323759 TI - Possibility of a DNA-containing mammary tumour virus in red blood cells of mouse. PMID- 4323760 TI - [Anti-inflammatory drugs]. PMID- 4323761 TI - [Cytological changes induced with actinomycin D in Yoshida's ascitic hepatoma]. PMID- 4323762 TI - Electron transport in microsomes from rat liver and hepatomas. PMID- 4323763 TI - [Nutritional neuropathies]. PMID- 4323764 TI - [Metabolic effects of drugs]. PMID- 4323765 TI - [Renal cortex micronodules of blastematous aspect in young children]. PMID- 4323767 TI - Neutralizing antibodies to SV40 in human sera from South India: search for additional hosts of SV40. PMID- 4323766 TI - Dizziness--it may be serious. PMID- 4323768 TI - Herpesvirus infection of guinea pigs. I. Isolation, characterization and pathogenicity. PMID- 4323769 TI - Herpesvirus infection of guinea pigs. II. Transplacental transmission. PMID- 4323771 TI - [Poliomyelitis in Belgium (1967)]. PMID- 4323772 TI - [Reese's retinal dysplasia and cytomegalic inclusion disease]. PMID- 4323770 TI - An extracellular product of Mycobacterium phlei. II. Its effect on the mitochondrial NADH dehydrogenase and tetrazolium reductase systems. PMID- 4323773 TI - [Urinary excretion of testosterone in Stein-Leventhal's syndrome]. PMID- 4323774 TI - [Hypothalamo-pituitary-adrenal function in hyperthyroidism and hypothyroidism]. PMID- 4323775 TI - [Cystic manifestation of malignant tumors in the lung]. PMID- 4323776 TI - Studies on the influence of host defence mechanisms on the antimicrobial effect of chemotherapeutic agents. I. The inluence of serum constituents on the in vitro effect of gentamicin and polymyxin. PMID- 4323777 TI - Metabolic inestigations of the rat kidney after administration of polythiazide, furosemide, and ethacrynic acid. II. Changes of some enzyme activities in mitochondria ofthe renal cortex and medulla. PMID- 4323778 TI - Studies on the leukocytosis and lymphocytosis induced by Bordetella pertussis. 3. The distribution of transfused lymphocytes in pertussis-treated and normal mice. AB - Peripheral blood lymphocytes were isolated from normal mice and mice undergoing pertussis-induced lymphocytosis. After labeling in vitro with tritiated uridine the cells were transfused into normal or pertussis-treated mice. It was found that the lymphocytes from pertussis-treated mice entered the lymph nodes of both normal mice and pertussis-treated mice to a significantly lesser extent than did normal lymphocytes which had been transfused into either class of recipient. In addition, an interdependence of changes in the various body compartments examined was found when normal lymphocytes were injected into either type of recipient. However, when pertussis lymphocytes were injected into normal mice there was no interrelationship between the changes in the node with those in the blood, liver, lung, or spleen. In the case of pertussis lymphocytes transfused into pertussis treated mice no interrelationship between any two compartments was observed. It was concluded that in pertussis-treated mice there is an inhibition of lymphocyte emigration which is primarily the consequence of an effect on the cell. PMID- 4323779 TI - The subendothelial microfibril and platelet adhesion. PMID- 4323781 TI - Basic cellular lesion in chloroquine toxicity. PMID- 4323780 TI - Transformation of reticulum cells to lymphoblasts in cultures of bovine spleen infected with Theileria parva. PMID- 4323782 TI - [Diagnosis and symptoms of mammary carcinoma]. PMID- 4323783 TI - Endocrine control of avian carbohydrate metabolism. PMID- 4323784 TI - Induction of mitochondrial DNA synthesis in monkey cells infected by simian virus 40 and (or) treated with calf serum. AB - Infection of confluent monolayer cultures of African green monkey kidney cells with simian virus 40 results in an enhanced synthesis of nuclear and mitochondrial DNA. This is demonstrated both by an increased rate of incorporation of [(3)H]thymidine into mitochondrial DNA and by detection of increased amounts of mitochondrial DNA in infected cells. With monkey BSC-1 cells, where SV40 infection does not result in a stimulation of nuclear DNA synthesis, no stimulation of mitochondrial DNA synthesis is observed. SV40 infection of mouse 3T3 cells also stimulates nuclear and mitochondrial DNA synthesis. PMID- 4323785 TI - Interconversion of cyclic nucleotide-activated and cyclic nucleotide-independent forms of a protein kinase from beef heart. AB - A protein kinase activated by cyclic nucleotides was purified from beef heart. Upon exposure to adenosine 3':5'-cyclic monophosphate (cyclic AMP) during gel filtration on Sephadex G-200, the protein kinase dissociated into a cyclic nucleotide-independent protein kinase and a cyclic nucleotide-binding protein. A similar or identical cyclic nucleotide-independent protein kinase could be obtained in highly purified form by clution from a DEAE-cellulose column with 10( 6) M cyclic AMP; the cyclic AMP-binding protein was apparently retained by the resin. The addition of cyclic nucleotide-binding protein to cyclic nucleotide independent protein kinase resulted in the reappearance of cyclic nucleotide dependent protein kinase, which could be isolated by filtration on Sephadex G-200 in the absence of cyclic AMP. These results confirm and extend previous suggestions that cyclic nucleotides activate protein kinases by dissociating them from inhibitory, cyclic nucleotide-binding proteins. PMID- 4323786 TI - A simple, sensitive protein-binding assay for guanosine 3':5'-monophosphate. AB - A protein-binding assay for guanosine 3':5'-monophosphate, which employs an enzyme preparation from lobster tail muscle, is described. The binding constant for cyclic GMP was 2-10 nM for four different enzyme preparations. The method can be set up in several days and permits the detection of as little as 0.5-1 pmol of cyclic GMP. In some instances, it is possible to assay the nucleotide in urine or deproteinized extracts of tissue without purification. For other samples, a simple method for separating and purifying cyclic AMP and cyclic GMP is described. PMID- 4323787 TI - Further characterization of the cellular DNA hybridizing with the RNA of Rous sarcoma virus. AB - Both 70S and 4S RNAs of Rous sarcoma virus (RSV) contain nucleotide sequences homologous to those in cellular DNA. Preparations of these RNAs were found to include some adventitious cellular sRNA. Nevertheless, both 70S and 4S RSV-RNAs were found by competition techniques to contain sequences distinct from those in cellular ribosomal RNA and 4S RNA. Competition experiments also reveal substantial homology between 70S and 4SRSV-RNA. In hybridization experiments performed in formamide at low temperatures, the melting profiles of hybrids between 70S RSV-RNA and cellular DNA, and 4S RSV-RNA and cellular DNA, are essentially superimposable. It is suggested that there are at least two origins of 4S RSV-RNA in RSV-RNA preparations: degradation of 70S RSV-RNA and inclusion of adventitious cellular 4S RNA. The possibility of a specific viral 4S RNA is not excluded. PMID- 4323788 TI - Properties of a soluble DNA polymerase isolated from Rous sarcoma virus. AB - The DNA polymerase of the Prague strain of Rous sarcoma virus of subgroup C and of the Schmidt-Ruppin strain of subgroup A has been solubilized. DNA polymerase purified by sucrose gradient sedimentation and chromatography on DEAE-cellulose represented less than 2% of the soluble [(14)C]protein of the virus. The enzyme was separated from 90% of the viral glycoprotein; it is probably different from the viral group-specific antigen. The sedimentation coefficient (s(20, w)) of the soluble DNA polymerase was 8 S before, and 6 S after, incubation with pancreatic RNase. The molecular weight of the 8S DNA polymerase was estimated to be about 170,000, and that of the 6S DNA polymerase to be about 110,000. Purified DNA polymerase had a high activity with 60-70S viral RNA or salmon DNA as template, but it had a low activity with heat-dissociated 60-70S RNA, influenza virus RNA, or the RNA of tobacco mosaic virus as template. Neither the 8S nor the 6S DNA polymerase had endogenous template activity. The DNA-dependent and the RNA dependent DNA polymerase activities of the Prague strain coincided in sucrose gradients, both in the 8S and the 6S form. It is concluded that the RNA-dependent and the DNA-dependent DNA polymerase activities of the avian tumor viruses are probably due to the same enzyme. PMID- 4323790 TI - Identification of 1,25-dihydroxycholecalciferol, a form of vitamin D3 metabolically active in the intestine. AB - A biologically active vitamin D(3) metabolite ("peak V metabolite") more polar than 25-hydroxycholecalciferol has been isolated from chicken intestines in pure form as a mono(trimethylsilyl)ether derivative. The molecule has been identified as 1,25-dihydroxycholecalciferol by means of mass spectrometry, ultraviolet absorption spectrophotometry, and specific chemical reactions. PMID- 4323789 TI - Role of the receptor in the mechanism of action of adenosine 3':5'-cyclic monophosphate. AB - Highly purified cAMP-dependent protein phosphokinase from adrenal-cortical tissue contains cAMP-receptor activity. In activating the kinase, cAMP binds to the receptor and causes it to dissociate from its complex with the kinase. The kinase, freed of receptor, is fully activated and no longer stimulable by cAMP. Kinase can be similarly activated by differentially denaturing the receptor with heat. Addition of receptor suppresses kinase activity; this suppression can be overcome by cAMP. After dissociation of receptor, two molecular forms of the activated kinase exist. The cAMP receptor thus functions as a repressor of the protein kinase; binding of cAMP to receptor causes it to dissociate from the kinase, which is then fully activated. PMID- 4323791 TI - Pavlovian pattern learning by nonlinear neural networks. AB - This note describes laws for the anatomy, potentials, spiking rules, and transmitters of some networks of formal neurons that enable them to learn spatial patterns by Pavlovian conditioning. Applications to spacetime pattern learning and operant conditioning are then possible, if the conditioning is viewed as multi-channel Pavlovian conditioning in a highly inhomogeneous anatomy. In suitable anatomies, biases in learning because of axon collaterals with nonuniformly distributed diameters can be corrected if one properly couples the action potential to transmitter potentiation, and chooses signal velocity proportional to axon diameter. These anatomies can contain any number of cells. Anatomies exist in which patterns may be learned without their being practiced overtly, whereas persistent recall of old patterns without the learning of newly imposed patterns is impossible. Physiologically, this constraint has the trivial interpretation that signals from one cell to another first pass through the intervening synaptic knob. Mechanisms that control learning rates at times important to the network (e.g., reward and punishment times) can be discussed. Serial behavior like that described by Lashley is possible: this consists of sequential learning and performance of patterns faster than would be allowed by a motor-feedback control, at velocities influenced by arousal level, with the possibility of abrupt termination of performance if conflicting environmental demands arise. Analogs of pattern completion and mass action exist, as do phase transitions in memory (for some rate parameters and anatomies, memory is rigid, for others, it is plastic). The laws limit the ways in which these networks can be interconnected to yield specific discrimination, learning, memory, and recall capabilities. PMID- 4323793 TI - Structural measurements in hemoprotiens: use of spin-labeled protoheme as a probe of heme environment. AB - With the aid of two kinds of spin-labeled protohemins, the nature of the heme protein interaction of various hemoproteins was investigated. Di- and mono-spin labeled protohemins were prepared from protohemin and 2,2,5,5-tetramethyl-3 aminopyrrolidine-1-oxyl. The spin-labeled hemins were recombined with apoproteins of hemoglobin (Hb), myoglobin (Mb), cytochrome c peroxidase (EC 1.11.1.5) and horseradish peroxidase (EC 1.11.1.7). Electron paramagnetic resonance spectra of the di- and mono-spin-labeled hemoglobin in 0.1 M potassium phosphate buffer, pH 7.0, at 20 degrees C exhibited moderate immobilization of the labels, while that of cytochrome c peroxidase showed stronger immobilization. Di-spin-labeled horseradish peroxidase showed an EPR spectrum of a simple broad line with peak-to peak line width of 35 G. This broadening is due to spin-spin interaction between the two labels attached at the 6- and 7-positions of the porphyrin ring. Ligand binding to the spin-labeled hemoproteins altered the EPR line shapes and amplitudes. The former is attributed to the changes in the mobility of the labels and the latter to the magnetic dipolar interaction between the heme iron and free radical. From the strength of this interaction the distance between the iron and the nitroxide radical may be calculated. In the hemoproteins examined, the distances are: Hb 12.5 A, Mb 12.0 A, cytochrome peroxidase approximately 14 A, and horseradish peroxidase 9.0 A. PMID- 4323794 TI - Relaxing effect of ACTH on human bronchial muscle in vitro. PMID- 4323795 TI - Immunoglobulin production by human lymphocytoid lines and clones: absence of genic exclusion. AB - Immunoglobulin production was studied in established lines of normal human lymphocytes. Three lines which produced both immunoglobulin G and immunoglobulin M were cloned. Among the 25 immunoglobulin-producing clones, 23 produced both classes of immunoglobulins. These findings suggest that the phenomenon of genic exclusion does not hold for immunoglobulin production in lymphocytoid cells in culture. PMID- 4323792 TI - Viruses as an aid to cancer therapy: regression of solid and ascites tumors in rodents after treatment with bovine enterovirus. AB - Treatment of ascites and solid tumors in mice (Sarcoma-1 and Ehrlich ascites carcinoma) with bovine enterovirus-1 resulted in regression of the tumors without any pathological effect on the animals. Death of mice with lymphatic-leukemia L4946 was delayed after such treatment. The oncolytic specificity of the virus does not appear to involve the production of interferon, but requires specific adsorption of virus to the tumor cells. The specificity of killing extends to cells in culture, since viral-transformed cells and oncogenic cells are susceptible to the virus, in contrast to cells of untransformed lines and cells of primary cultures, which are resistant. The possibility of utilizing the specificity of nonvirulent viruses in therapeutic treatment of human cancers is considered. PMID- 4323796 TI - EEG responses in regularly menstruating women and in amenorrheic women treated with ovarian hormones. AB - Electroencephalographic driving reponses to photic stimulation vary with the menstrual cycle and with manipulations of ovarian hormones thought to control the menstrual cycle. Estrogens reduce driving responses to photic stimulation, and estrogen plus progesterone enhance these responses. The electroencephalographic changes may reflect the effects of gonadal steroid hormones upon central adrenergic processes. PMID- 4323798 TI - Developing neuromuscular junctions: first signs of chemical transmission during formation in tissue culture. AB - Electrophysiological study of rat neuromuscular junctions in the early stage of formation in tissue culture showed that chemical transmission begins with discrete, localized release of transmitter about the time when nerve-muscle contacts are first visible with light microscopy. Noncontractile myotubes with as few as three nuclei showed evidence of junctional transmission. PMID- 4323797 TI - Telemetered recording of hormone effects on hippocampal neurons. AB - Frequency-modulated telemetry was used to record the effects of hormones on single-unit activity in the brains of freely moving rats. Corticosterone decreased unit activity in the dorsal hippocampus. Adrenocorticotrophic hormone had the opposite effect. PMID- 4323799 TI - Deuterium effects on binding of reduced coenzyme alcohol dehydrogenase isoenzyme EE. AB - Determination of dissociation constants by two different methods yield the following mean values in 20 millimolar phosphate, pH 7.0, 25 degrees C: 0.27 micromolar for reduced nicotinamide adenine dinucleotide (NADH); 0.29 micromolar for NADH with deuterium in the nicotinamide 4-B position (B-NADD); and 0.46 micromolar for NADH with deuterium in the nicotinamide 4-A position (A-NADD). These results indicate that dehydrogenases are capable of recognizing and distinguishing the appropriate hydrogen in the coenzyme already in the initial binding reaction. PMID- 4323800 TI - [Experimental hormonal therapy of skin allergic reactions in sensitized guinea pigs]. PMID- 4323801 TI - [Simultaneous vaccination of sheep against pox and anaerobic infections]. PMID- 4323802 TI - Mitotic rates of regenerating liver parenchyma and DAB induced primary hepatoma. PMID- 4323803 TI - The effect of combined respiratory and nonrespiratory alkalosis on energy metabolites and acid-base parameters in the rat brain. PMID- 4323804 TI - Comparative effects of angiotensin and noradrenaline on resistance, capacitance, and precapillary sphincter vessels in cat skeletal muscle. PMID- 4323805 TI - [Surgical aspects of orthotopic, human liver transplantation. Experiences of 3 liver transplantations]. PMID- 4323806 TI - Short- and long-term effect of ACTH in vivo on the incorporation of 3H-leucine into the submitochondrial fractions from rat adrenal glands. PMID- 4323807 TI - [Saluretic action of angiotensin II in essential and renovascular hypertension]. PMID- 4323809 TI - [Infectious mononucleosis--Epstein-Barr-Virus]. PMID- 4323808 TI - Spastic, an hereditary neurological mutation in the mouse characterized by vertebral arthropathy and leptomeningeal cyst formation. PMID- 4323810 TI - Haemagglutination-inhibiting variola antibodies in blood serum of former smallpox patients, their healthy siblings, and unvaccinated controls from other areas. PMID- 4323811 TI - [Transspecific variability of NAD-malate dehydrogenase in primates]. PMID- 4323812 TI - [Middle ear cancer]. PMID- 4323813 TI - [Mixed parotid tumor with frequent pharyngeal prolongement]. PMID- 4323814 TI - [Abrikossof tumors: 2 recent cases]. PMID- 4323815 TI - Localized forms of rhinoscleroma. PMID- 4323816 TI - Brief-tone audiometry in patients with 8th nerve tumor. PMID- 4323817 TI - [Hazards of the neuro-muscular blocking effect of antibiotics]. PMID- 4323819 TI - [Lipid mobilizing effect of a pituitary gland peptide in pigs of different species]. PMID- 4323820 TI - Recovery, Inc.: aid in the transition from hospital to community. PMID- 4323821 TI - Supportive outpatient treatment. PMID- 4323822 TI - [On bronchiolo-alveolar carcinoma of the lung]. PMID- 4323818 TI - [Regulation of aldosterone secretion]. PMID- 4323823 TI - [Bronchial adenoma. (Biological, anatomo-clinical and therapeutic considerations on 65 cases)]. PMID- 4323825 TI - Purity and stability of synthetic peptides such as angiotensins and kinins. PMID- 4323824 TI - Induction of directional chromosome elimination in somatic cell hybrids. PMID- 4323826 TI - Juxtaglomerular index and activity of the renin-angiotensin system. PMID- 4323827 TI - [Ultrastructural-morphometric study on rat liver parenchymal cells in acute adenine poisoning]. PMID- 4323829 TI - [Role of serum antibodies in the pathogenesis of experimental pertussis encephalomyelitis]. PMID- 4323828 TI - Birth, death and net growth of normal, transforming, neoplastic and malignant cell lines. Decrease of death rate in neoplastic alteration. PMID- 4323831 TI - [Effect of renin and angiotensin on the cardiovascular system]. PMID- 4323830 TI - [Change in cardiac muscle reactivity during the development of neural dystrophy]. PMID- 4323832 TI - [Effect of glucocorticosteroids on gastric secretory activity]. PMID- 4323833 TI - The treatment of small localized carcinoma of the breast with surgical removal of the tumour and radical implantation of radium. PMID- 4323835 TI - [Biological properties of the epizootic strain of chicken grippe virus]. PMID- 4323834 TI - [Endolymphatic therapy with labelled lipiodol--initial experiences]. PMID- 4323836 TI - [Effect of the trace element composition of meals on the activity of certain enzymes of bone tissue in experimental animals]. PMID- 4323837 TI - [Comparative results of the caloric test and the pendular test]. PMID- 4323838 TI - Adenovirus infection in acute hemorrhagic cystitis. A study in 25 children. PMID- 4323839 TI - Myocarditis and pneumonitis with type 21 adenovirus infection. Association with fatal myocarditis and pneumonitis. PMID- 4323840 TI - Intracavitary I-131-labeled BSP as follow-up for management of amebic liver abscess. PMID- 4323841 TI - Further studies on a collagenase in middle ear cholesteatoma. PMID- 4323842 TI - Papillomas of the nasal cavity and paranasal sinuses. A clinicopathological study of 315 cases. PMID- 4323843 TI - Activation of succinate dehydrogenase by electron flux from NADH and its possible regulatory function. PMID- 4323844 TI - Separation of protein components of mitochondrial complex IV and their molecular weights. PMID- 4323845 TI - Studies on calciferol metabolism. I. Production of vitamin D metabolite 4B from 25-OH-cholecalciferol by kidney homogenates. PMID- 4323846 TI - Platelet aggregation. IV. Platelet phosphodiesterase and its inhibition by vasodilators. PMID- 4323847 TI - Ferredoxin from Bacillus polymyxa. PMID- 4323848 TI - Mode of inhibition of DNA synthesis induced by adenosine diphosphoribosylation of nuclear protein. PMID- 4323849 TI - DNA polymerase activity in homogenates of cells infected with MC29 virus. PMID- 4323850 TI - Studies on thermal inactivation of transfer ribonucleic acid nucleotidyltransferase from Escherichia coli. PMID- 4323851 TI - Phospholipid metabolism during the development of the liver. The incorporation of [1,2-14C]ethanolamine, [2-3H]myo-inositol and L-[U-14C]serine into phospholipids by liver slices. PMID- 4323852 TI - Mass spectral analysis glycerophospholipids. PMID- 4323853 TI - Bradykinin-potentiating peptides from the venom of Agkistrodon halys blomhoffi. Isolation of five bradykinin potentiators and the amino acid sequences of two of them, potentiators B and C. PMID- 4323855 TI - Regulation of glutamate dehydrogenase by histidine. PMID- 4323854 TI - Use of a mixture of proteinase-free collagenases for the specific assay of radioactive collagen in the presence of other proteins. PMID- 4323856 TI - Microbial lipoamide dehydrogenase. Purification and some characteristics of the enzyme derived from selected microorganisms. PMID- 4323858 TI - Studies on particle-bound hexokinase in rat ascites hepatoma cells. PMID- 4323857 TI - Studies pertaining to the purification and properties of thymine 7-hydroxylase. PMID- 4323859 TI - Purification and properties of ATP-sulphurylase from Nitrobacter agilis. PMID- 4323861 TI - A fluorimetric assay method for the K plus-phosphatase associated with the (Na+ + K+)-activated ATPase. PMID- 4323862 TI - Electron spin resonance studies of ultraviolet irradiation effects on some proteins. PMID- 4323860 TI - Adenosine 3',5'-cyclic phosphate phosphodiesterase of corpus luteum. PMID- 4323863 TI - [Preliminary results of studies on lymphocytes, frozen and irradiated at low temperatures. 3. The behaviour of radiation induced radicals in frozen lymphocyte cultures depending on temperature]. PMID- 4323864 TI - Paramagnetic behaviour of the differentiating reproductive apex of wheat. PMID- 4323865 TI - Serum magnesium levels and magnesium trisilicate therapy in labour. PMID- 4323866 TI - Effect of propanidid on peripheral motor function in myasthenics. PMID- 4323867 TI - Cytomegalovirus meningo-encephalitis. PMID- 4323868 TI - Observations on clinical and immunofluorescent diagnosis of parainfluenza virus infections. AB - Immunofluorescent techniques have been applied to nasopharyngeal secretions for the rapid diagnosis of parainfluenza virus types 1, 2, and 3 infections. Seventy five infections were found by isolation techniques; 55 of these had nasopharyngeal secretions taken and 53 were positive by direct examination. A comparison of the results of 60 neutralization tests with immunofluorescence applied to monkey kidney isolations showed complete agreement. Immunofluorescence appeared to be a satisfactory method for differentiating the various haemadsorption viruses. The importance of parainfluenza viruses and respiratory syncytial virus in croup was noted and the association of the parainfluenza viruses with acute respiratory virus infection was confirmed. The clinical relationship between respiratory syncytial virus and parainfluenza virus type 3 is discussed. PMID- 4323869 TI - The effect of renin, angiotensin II and adrenalectomy on glomerular capillary permeability in the rat. PMID- 4323870 TI - Enzymes of glycogen metabolism in human skin with particular reference to differential diagnosis of the glycogen storage diseases. PMID- 4323871 TI - Chronic hypertension elicited by infusion of angiotensin into vertebral arteries of unanaesthetized dogs. PMID- 4323872 TI - [Virus induced breast carcinoma in humans?]. PMID- 4323873 TI - [Malignancy of intraoral salivary gland neoplasms]. PMID- 4323875 TI - Seasonal changes of pelage in the vole (Microtus agrestis). 3. The role of the endocrine system. PMID- 4323874 TI - Adrenal steroid biosynthesis by different species of mouselike rodents. PMID- 4323876 TI - The hormonal activities associated with the cephalic and caudal regions of the cockerel pars distalis. PMID- 4323877 TI - Histological and histochemical periodicity of cervine Leydig cells in relation to antler growth. PMID- 4323878 TI - Cold-induced necrosis in toes of chicks receiving daily dosages of adrenocorticotropin. PMID- 4323879 TI - Studies on a "renin-angiotensin" system in the normal and hypophysectomized pigeon (Columba livia). PMID- 4323881 TI - Removal of the outer membrane from brain mitochondria. PMID- 4323880 TI - Sodium and water movement across the urinary bladder of a urodele amphibian (th mudpuppy Necturus maculosus): studies and vasotocin and aldosterone. PMID- 4323882 TI - On functional role of cytochrome b5. I. NADH-linked cytochrome c reductase in microsomes. PMID- 4323883 TI - On functional role of cytochrome b5. II. NADH-linked ascorbate radical reductase activity in microsomes. PMID- 4323884 TI - Chemotherapy of acute intestinal and extra-intestinal amoebiasis with nitro imidazole. PMID- 4323886 TI - [Primary cancer of the liver in an infant]. PMID- 4323887 TI - [Multiple gastric ulcers and pancreatic tumor]. PMID- 4323885 TI - Complement requirement of neutralizing antibodies appearing after primary and booster immunizations with herpes simplex virus. PMID- 4323889 TI - [Release of prussic acid in cormophytes. 6. Further observations on cyanogenesis in Junci septati]. PMID- 4323888 TI - Changes in patterns of enzymes of carbohydrate metabolism in the developing rat kidney. PMID- 4323890 TI - [Carcinoma of the gastric stump after partial gastrectomy performed for ulcerous disease]. PMID- 4323891 TI - [Diagnostic and therapeutic difficulties in cases of multiple carcinoma of rectosigmoid]. PMID- 4323892 TI - Abdominal masses in infants. PMID- 4323893 TI - A granular cell myoblastoma. PMID- 4323894 TI - [Structure and properties of foot-and-mouth disease virus (review)]. PMID- 4323896 TI - [Antigenic properties of type C foot-and-mouth disease virus]. PMID- 4323895 TI - [Foot-and-mouth virus component responsible for immunogenesis]. PMID- 4323897 TI - [Virus-like structures in a lymph node of systemic lupus erythematosus]. PMID- 4323898 TI - Neurophysiological and neurobiochemical aspects of the role of catecholamines in the neurotransmission within the CNS. PMID- 4323899 TI - Red cell inclusions: a review. PMID- 4323900 TI - Effect of prostaglandin E1 on sodium transport and osmotic water flow in the toad bladder. PMID- 4323901 TI - Temperature, skeletal muscle mitochondrial functions, and oxygen debt. PMID- 4323902 TI - Carbohydrate metabolism of heat-acclimated hamsters. I. Control glycogenesis in the liver. PMID- 4323903 TI - Increased adrenocortical potassium in association with increased biosynthesis of aldosterone. PMID- 4323904 TI - Actions of inhibitor compounds on adenine nucleotides of renal cortex and sodium excretion. PMID- 4323905 TI - Influence of magnesium on drug-induced contractions and ion content in rabbit aorta. PMID- 4323907 TI - [Detection of a pox-virus in lovebirds (Agapornis personata and Agapornis roseicollis). Preliminary communication]. PMID- 4323906 TI - Endocrine aspects of the metabolic response to surgery. PMID- 4323908 TI - Cytomegalovirus infection in childhood leukaemia. PMID- 4323909 TI - Cytomegalovirus infection. PMID- 4323911 TI - [Atlas of myohistochemistry. 12. Congenital myopathy. 2]. PMID- 4323910 TI - Diabetes after removal of insulin tumours of pancreas: a long-term follow-up survey of 11 patients. AB - Eleven patients who had islet cell tumours of the pancreas removed over a 20-year period were reviewed. Two had died, one in the postoperative period and one 10 years post-operatively. The remaining nine were traced and eight of them were personally interviewed and tested. All nine were well and free from recurrent symptoms. Five of the eight had evidence of subnormal insulin production in response to oral glucose. Glucose tolerance was impaired in three. Minor anomalies were found in the electroencephalograms of all these patients and major abnormalities in two.The results of this survey suggest that other patients who have had islet cell tumours removed may now have unsuspected diabetes. PMID- 4323912 TI - [Benign breast tumors and development of carcinoma]. PMID- 4323913 TI - Fluctuating virus and enzyme levels in plasma of mice infected with the Friend leukemia virus. PMID- 4323915 TI - The effect of carbon monoxide inhibition on the growth of an aquatic streptomycete. PMID- 4323914 TI - Changes in phosphorus composition of Candida utilis during the cell cycle and postcycle period. PMID- 4323917 TI - Structural changes in cells of Clostridium perfringens infected with a short tailed bacteriophage. PMID- 4323916 TI - Immunization of sheep against experimental Clostridium perfringens type A enteritis. PMID- 4323918 TI - Spread of testicular tumours. PMID- 4323919 TI - Facilitation of tumour spread in irradiated tissue after prophylactic post operative x-ray therapy for breast cancer. PMID- 4323920 TI - Some observations on the value and techniques of myelography in lumbar disc lesions. The results over a five year period at the Nuffield orthopaedic centre, Oxford. PMID- 4323922 TI - [Chromatographic antibody determination with P32-labelled polio viruses and comparison of the results with the neutralization test]. PMID- 4323921 TI - An experimental and clinical assessment of water-soluble contrast medium in neuroradiology: a new medium--Dimer-X. PMID- 4323923 TI - A C1-fixation method for the measurement of chicken anti-viral antibody. PMID- 4323924 TI - Neopluramycin, an inhibitor of nucleic acid synthesis. PMID- 4323925 TI - Effects of neopluramycin on ascites tumors implanted in experimental animals. PMID- 4323926 TI - [Electron microscopic study on the phagocytosis of crystals by the synovial fluid cells]. PMID- 4323927 TI - Inactivation of Escherichia coli ribosomes by 1-fluoro-2,4-dinitrobenzene. PMID- 4323928 TI - The 5 A resolution structure of an abortive ternary complex of lactate dehydrogenase and its comparison with the apo-enzyme. PMID- 4323929 TI - The secondary structure of bacteriophage DNA in situ. 3. Reaction of Sd phage with O-methylhydroxylamine. PMID- 4323930 TI - Ribosomal proteins and the conformation of ribosomal ribonucleic acid. PMID- 4323931 TI - Deletion mutants of bacteriophage lambda. I. Isolation and initial characterization. PMID- 4323932 TI - The aetiology of primary liver cancer in the Bantu. PMID- 4323933 TI - Correlation between nerve terminal size and transmitter release at the neuromuscular junction of the frog. AB - 1. End-plate potentials were recorded intracellularly at the frog neuromuscular junction bathed in a solution containing a low concentration of calcium and a high concentration of magnesium.2. The muscle was subsequently subjected to ;cholinesterase staining', and the area of the individual end-plates, studied with intracellular electrodes, was measured.3. A positive correlation was found between the end-plate area and the diameter of muscle fibres.4. The mean quantum content (m) showed a positive correlation with the size of end-plates.5. The frequency of spontaneous miniature end-plate potentials was positively correlated with m as well as with end-plate area.6. It is concluded that the amount of transmitter released following nerve stimulation is related to the size of nerve endings. PMID- 4323934 TI - The effect of ACTH on calcium distribution in the perfused cat adrenal gland. AB - 1. Experiments were carried out to study the effects of adrenocorticotrophin (ACTH) on calcium distribution in the isolated cat adrenal gland perfused with Locke solution.2. The addition of ACTH to Locke solution caused a small, but significant, increase in the radiocalcium ((45)Ca) space and content of the adrenal cortex.3. The average (45)Ca washout curve obtained after exposure to ACTH was significantly displaced above the average washout curve for the control glands during the first 20 min of washout. During the time that the two curves were significantly different, maximum corticosteroid secretion was attained.4. The rate of (45)Ca efflux was slowed after ACTH was added to the perfusion medium.5. The total calcium content of the cortex was not altered by ACTH.6. Perfusion with calcium-free Locke caused a rapid decrease in the calcium content of the cortex to about 20% of the control value. Dinitrophenol was required to deplete completely the cortical calcium content during perfusion with the calcium deprived medium.7. The results are consistent with the suggestion that a translocation of calcium occurs during stimulation of the cortex by ACTH. The source of the calcium ions needed to support the secretory response to ACTH is probably not the extracellular fluid; but ACTH may shift calcium from a rapidly exchanging to a more slowly exchanging cellular pool. PMID- 4323935 TI - Does curare affect transmitter release? AB - 1. The effect of curare on the amount of transmitter released by a nerve stimulus was studied in frog and rat nerve-muscle preparations using electrophysiological techniques.2. When the frog sartorius nerve-muscle preparation was exposed to low doses of curare, the amplitudes of spontaneous miniature end-plate potentials and end-plate currents (e.p.c.s, measured under ;voltage clamp' conditions) were reduced to the same extent, suggesting that the drug did not alter the number of transmitter quanta released by nerve stimulation.3. With higher doses of curare in frog muscle treated with glycerol to abolish twitching, quantum content was estimated from the coefficient of variation (CV) of e.p.c.s. The measured CV increased slightly in curare; this increase probably resulted from a relatively greater contribution of random noise to the observed fluctuations when the e.p.c. was reduced by curare.4. In the rat diaphragm, muscle fibres were cut to block twitching. This procedure produced, among other changes, a reduction in the muscle fibre space constant, so that junctional signals were distorted by the cable properties of the muscle fibre when, as often occurred, micro-electrodes were more than 100-200 mu from the end-plate focus. This produced errors in estimates of quantum content; when these errors were accounted for, it appeared that curare did not significantly alter quantum content.5. It is concluded that if curare affects transmitter release at all, its effect must be much smaller than its well known post-synaptic blocking action. PMID- 4323936 TI - Contractile and electrical responses of vagus-innervated frog sartorius muscles. AB - 1. Frog sartorius muscles were transplanted to the thoracic region and re innervated by the gastric vagus nerve. Contractile responses of the re-innervated muscles were studied. Micro-electrodes were used to measure electrical properties of the muscle fibre membrane. Histological studies of the sartorius and vagus nerves and re-innervated muscles were also carried out.2. Autonomic nerve fibres of the gastric vagus form functional connexions with the skeletal muscle fibres. Such vagus-innervated muscle fibres do not atrophy.3. Neither the contractile nor the passive electrical properties of the muscle fibres are altered by vagal innervation.4. Synaptic transmission is quantal in nature and describable by a Poisson distribution as at normal sartorius junctions. The muscle fibres, however, do show extensive multiple-innervation, and unlike normal sartorius junctions, vagus-muscle junctions have a low quantal content and show a long lasting facilitation.5. Properties of the vagus nerve fibres apparently are not altered by synapsing with skeletal muscle fibres. They remain small diameter and have high threshold for electrical stimulation.6. The ability of these nerve and muscle fibres to influence each other is rather limited in the adult amphibian. PMID- 4323937 TI - Incorporation of (U-14C)palmitic acid into the phospholipids of bovine semen. PMID- 4323938 TI - [Polygraphical study on the wakefulness-sleep cycle of the rat]. PMID- 4323939 TI - Juvenile fibroangioma of the postnasal space in service personnel. PMID- 4323940 TI - Role of kinins and prostaglandins as mediators of functional hyperaemia. PMID- 4323942 TI - Peripheral neuropathy: electrodiagnostic aspects. PMID- 4323941 TI - Radiological contrast media: the present and the future. PMID- 4323943 TI - [Tumors of the nervous system in children and adolescents in the records of patients of the Oncological Department in Pilsen during the years 1959-1968]. PMID- 4323944 TI - [A hormone-active islet cell tumor with distant metastases]. PMID- 4323945 TI - A spectrophotometric method for the simultaneous measurement of L-glutamine and L asparagine in biological materials. PMID- 4323946 TI - Preparation of labeled nucleotides. 3. 14C-labeled adenosine, guanosine, and inosine phosphates, and 32P-labeled inosine monophosphate. PMID- 4323947 TI - Comparative study of various extraction methods for the quantitative determination of free amino acids from brain tissue. PMID- 4323948 TI - Plasma cortisol response to dexamethasone suppression in depressed and control patients. PMID- 4323949 TI - Urinary cyclic AMP excretion in depression and mania. Effects of levodopa and lithium carbonate. PMID- 4323950 TI - [Light- and electron microscopic studies on the reciprocity between amorphous SiO2 and tissue]. PMID- 4323951 TI - [Studies on the mechanism of cytotoxicity of silicogenic dusts]. PMID- 4323953 TI - [Evolution of a horse sickness epizootic in Morocco (February 1966--December 1966)]. PMID- 4323952 TI - [Production and control of inactivated vaccines against horse sickness]. PMID- 4323955 TI - [Signal transmission in the nerves]. PMID- 4323954 TI - [Cyclic 3',5'-adenosine monophosphate (cAMP): mediator of intracellular hormonal activity]. PMID- 4323956 TI - Mechanism of the alcohol dehydrogenases from yeast and horse liver. PMID- 4323957 TI - X-ray small-angle scattering of yeast glyceraldehyde-3-phosphate dehydrogenase as a function of saturation with nicotinamide-adenine-dinucleotide. PMID- 4323958 TI - [Physiological and structural-chemical basis of the neuron memory]. PMID- 4323959 TI - [Hormone-receptor-relationships: synthesis and characteristics of N-epsilon dansyllysine 21-adrenocorticotropin-(1-24)-tetrakosipeptide]. PMID- 4323960 TI - Induction and repression of L-arabinose isomerase in Salmonella typhimurium. AB - As with other inducible enzymes, the induced synthesis of l-arabinose isomerase (l-arabinose ketol isomerase, EC 5.3.1.4) in Salmonella typhimurium is subject to catabolite repression. Of the three catabolite repressors tested, glucose produces maximum repression. Analogues of catabolite repressors like 2-deoxy-d glucose and d-fucose also inhibit the synthesis of the enzyme. The catabolite repression is completely reversed in the presence of 1.5 x 10(-3)m cyclic 3',5' adenosine monophosphate (AMP). The maximum repression is produced in glucose grown cells in glucose-containing induction medium. Cyclic 3',5-AMP reverses this repression provided that the cells are treated with ethylenediaminetetraacetic acid (EDTA). In normal cells, cyclic 3',5'-AMP has no effect on the induction but in EDTA-treated cells the cyclic nucleotide enhances synthesis of the enzyme. The inhibition produced by d-fucose cannot be reversed by cyclic 3',5'-AMP. d-Fucose competes with the inducer l-arabinose in some step(s) involved in the process of induction. PMID- 4323961 TI - Immunological relationships among lactic dehydrogenases in the genera Lactobacillus and Leuconostoc. AB - Antisera were prepared against pure nicotinamide adenine dinucleotide-dependent d lactic dehydrogenases of Lactobacillus leichmannii, L. jensenii, and L. fermenti. When tested against these three antisera, crude extracts of almost all species of Lactobacillus containing a d-lactic dehydrogenase give cross-reactions. Extensive pairwise comparisons between cross-reacting crude extracts by double diffusion experiments permit the recognition of groups of identical antigenic specificity among the lactic dehydrogenases of the various nomenspecies of Lactobacillus. The same groups are revealed by each of the three antisera. By analyses of spur formation, the groups of identical antigenic specificity can be arranged in order of decreasing similarity to the homologous d-lactic dehydrogenase used as the reference point. From the combined results obtained with the three antisera, a map of the antigenic relationships among the d-lactic dehydrogenases of lactobacilli can be constructed. Microcomplement fixation experiments with two of the three anti-d-lactic dehydrogenases antisera support the conclusions drawn from double diffusion experiments and provide a quantitative estimation of the antigenic relationships among the various d-lactic dehydrogenases. An antiserum was also prepared against the pure l-lactic dehydrogenase of L. acidophilus group III. It cross-reacts with extracts of almost all lactobacilli containing an l lactic dehydrogenase. With respect to species that contain both d- and l-lactic dehydrogenases, this antiserum reveals the same groups of identical antigenic specificity as do the antisera directed against d-lactic dehydrogenases. Other than the genus Lactobacillus, only extracts of Leuconostoc cross-react with anti d-lactic dehydrogenase. No extrageneric cross-reactions were obtained with the anti-l-lactic dehydrogenase. PMID- 4323963 TI - Respiratory chain of a pathogenic fungus, Microsporum gypseum: effect of the antifungal agent pyrrolnitrin. AB - Pyrrolnitrin has been reported to inhibit Bacillus megaterium primarily by forming complexes with phospholipids and to block electron transfer of Saccharomyces cerevisiae between succinate or reduced nicotinamide adenine dinucleotide (NADH) and coenzyme Q. We found that pyrrolnitrin inhibited respiration of conidia of Microsporum gypseum. In mitochondrial preparations, pyrrolnitrin strongly inhibited respiration and the rotenone-sensitive NADH cytochrome c reductase. The rotenone-insensitive NADH-cytochrome c reductase, the succinate-cytochrome c reductase, and the reduction of dichlorophenolindophenol by either NADH or succinate were inhibited to a lesser extent. However, the activity of cytochrome oxidase was not affected by pyrrolnitrin. The extent of reduction of flavoproteins by NADH and succinate, measured at 465 - 510 nm, was unaltered; however, the reduction of cytochrome b, measured at 560 - 575 nm, was partially inhibited by pyrrolnitrin. The level of totally reduced cytochrome b was restored with antimycin A. We, therefore, concluded that the primary site of action of this antifungal antibiotic is to block electron transfer between the flavoprotein of the NADH-dehydrogenase and cytochrome b segment of the respiratory chain of M. gypseum. PMID- 4323962 TI - Comparative biochemical and immunological study of malic enzyme from two species of lactic acid bacteria: evolutionary implications. AB - Representatives of both Streptococcus faecalis and Lactobacillus casei produce isofunctional malic enzymes. All 10 strains of S. faecalis tested could be induced to synthesize malic enzyme and readily adapted to growth on malate. Although 17 of 21 L. casei strains could be induced to produce malic enzyme, only 9 of 14 strains tested grew at the expense of malate. A comparison of catalytic and regulatory properties suggested that the malic enzymes from S. faecalis and L. casei were very similar. Immunological analyses showed that the numerous similarities in function actually reflected partial protein homologies; however, two distinct forms of the malic enzyme were detected among different strains of L. casei by immunochemical and serological procedures. The division of L. casei into two subgroups based on the immunological type of malic enzyme synthesized corresponds to two subspecies currently recognized by microbial taxonomists. PMID- 4323964 TI - Saturated fatty acid requirer of Neurospora crassa. AB - Dietary saturated fatty acids containing 12- to 18-carbon atoms satisfy growth requirements of Neurospora crassa mutant cel (previously named ol; Perkins et al., reference 11); unsaturated fatty acids are synthesized by direct desaturation when an appropriate saturate is available. Odd-chain saturates, 15 carbons and 17 carbons long, satisfy the requirement, and elaidic acid (18:1 Delta(9)trans) results in slow growth. Oleic acid and other cis-unsaturated fatty acids do not satisfy growth requirements; however, oleic acid plus elaidic acid result in growth at a faster rate than elaidate alone. The use of a spin-label fatty acid reveals that hyphae produced by cel during a slow basal level of growth have lipids that reflect a relatively rigid state of viscosity compared to wild type. cel Supplemented with fatty acids and wild type supplemented in the same way have lipids of the same viscosities as reflected by electron spin resonance. PMID- 4323965 TI - Membranous inclusions of Pseudomonas aeruginosa. AB - Electron microscopy of sectioned cells of Pseudomonas aeruginosa treated with a double fixative in N-2-hydroxyethylpiperazine-N-2-ethanesulfonic acid revealed a number of membranous inclusions varying in size and morphology. One round, electron transparent form was frequently observed which did not routinely appear to be attached to the cytoplasmic membrane and varied in size from 120 to 300 nm in diameter. However, in one case, several tubular structures between an inclusion and the cytoplasmic membrane was observed. On rare occasions, a large and unusual multilayered inclusion consisting of three thick and distinct layers was also encountered. In addition, two small mesosomal structures were singly observed in cells and were situated proximal to the cytoplasmic membrane. One type appeared to consist of a single thin membrane, whereas the other type consisted of a delicate, multilayered structure. PMID- 4323966 TI - Maintenance and exchange of the aromatic amino acid pool in Escherichia coli. AB - The pool of phenylalanine, tyrosine, and tryptophan is formed in Escherichia coli K-12 by a general aromatic transport system [Michaelis constant (K(m)) for each amino acid approximately 5 x 10(-7)m] and three further transport systems each specific for a single aromatic amino acid (K(m) for each amino acid approximately 2 x 10(-6)m, reference 3). When the external concentration of a particular aromatic amino acid is saturating for both classes of transport system, the free amino acid pool is supplied with external amino acid by both systems. Blocking the general transport system reduces the pool size by 80 to 90% but does not interfere with the supply of the amino acid to protein synthesis. If, however, the external concentration is too low to saturate specific transport, blocking general transport inhibits the incorporation of external amino acid into protein by about 75%. It is concluded that the amino acids transported by either class of transport system can be used for protein synthesis. Dilution of the external amino acid or deprivation of energy causes efflux of the aromatic pool. These results and rapid exchange observed between pool amino acid and external amino acids indicate that the aromatic pool circulates rapidly between the inside and the outside of the cell. Evidence is presented that this exchange is mediated by the aromatic transport systems. Mutation of aroP (a gene specifying general aromatic transport) inhibits exit and exchange of the small pool generated by specific transport. These findings are discussed and a simple physiological model of aromatic pool formation, and exchange, is proposed. PMID- 4323967 TI - Metabolism of D-arabinose: origin of a D-ribulokinase activity in Escherichia coli. AB - The kinase responsible for the phosphorylation of d-ribulose was purified 45.5 fold from a strain of Escherichia coli K-12 capable of growth on d-arabinose with no separation of d-ribulo- or l-fuculokinase activities. Throughout the purification, the ratios of activities remained essentially constant. A nonadditive effect of combining both substrates in an assay mixture; identical K(m) values for adenosine triphosphate with either l-fuculose or d-ribulose as substrate; and, the irreversible loss of activity on both substrates, after removal of magnesium ions from the enzyme preparation, suggest that the dual activity is due to the same enzyme. A fourfold greater affinity of the enzyme for l-fuculose than for d-ribulose, as well as a higher relative activity on l fuculose, suggest that the natural substrate for this enzyme is l-fuculose. The product of the purified enzyme, with d-ribulose as substrate, was prepared. The ratio of total phosphorous to ribulose phosphate was 1.01:1, indicating that the product was ribulose monophosphate. The behavior of the kinase product in the cysteine-carbazole and orcinol reactions, as well as the results of periodate oxidation assays, provided evidence that it was not d-ribulose-5-phosphate. Reaction of this compound with a cell-free extract of E. coli possessing l fuculose-l-phosphate aldolase activity resulted in the production of dihydroxyacetone phosphate and glycolaldehyde. The kinase product failed to reduce 2,3,5-triphenyltetrazolium and possessed a half-life of approximately 1.5 min in the presence of 1 n HCl at 100 C. These properties suggested that the phosphate group was attached to carbon atom 1 of d-ribulose. PMID- 4323969 TI - Acid phosphatases from Fusarium moniliforme. Purification and enzymatic properties. PMID- 4323968 TI - Lipid composition in rabbit sarcoplasmic reticulum and occurrence of alkyl ether phospholipids. PMID- 4323970 TI - Inactivation of Na plus-K plus-dependent ATPase by phospholipase-treatment and its reactivation by phospholipids. PMID- 4323971 TI - Structural studies on a glucose-containing polysaccharide obtained from Micrococcus lysodeikticus cell walls. II. Determination of the linkage points on N-acetyl-mannosaminuronic acid and its configuration. PMID- 4323972 TI - Treatment of ocular myasthenia with corticotrophin. AB - Nine patients with severe myasthenia gravis, including ocular symptoms, who did not respond to anticholinesterase therapy were given prolonged courses of corticotrophin. In all patients except one there was an initial deterioration, sometimes necessitating assisted respiration, followed by a marked improvement which persisted for many weeks and occasionally months. It is concluded that corticotrophin should be continued for at least two weeks as the onset of the remission might be delayed. Repeated courses or small maintenance doses prolonged the remission. Fluid retention and hypokalaemia were common unwanted effects but necessitated stopping the treatment in only one patient. PMID- 4323973 TI - Neuropathy associated with lymphoma. AB - Electrophysiological studies have been performed on 62 subjects with malignant lymphoma and the results compared with those of 35 control subjects matched for age. There was evidence of impairment of conduction consistent with a generalized peripheral neuropathy in 22 subjects (35%). Histological and electronmicroscopic studies were performed on sural nerve biopsy material from five subjects, and the pathological abnormalities of the myelinated fibres were those of axonal degeneration and segmental demyelination. The unmyelinated fibres were not affected. PMID- 4323975 TI - Separating determination of flavins using thin layer chromatography. PMID- 4323974 TI - Progesteroids as immunosuppressive agents. PMID- 4323976 TI - [Anti-inflammatory function of adrenal glands in patients with pituitary dwarfism]. PMID- 4323977 TI - Determination of 17-ketosteroids and adrenocortical steroids by gradient elution chromatography on a silicic acid column. PMID- 4323978 TI - Acute adaptational disturbances due to the imbalance of the autonomic nervous system. PMID- 4323980 TI - The fine structure of the tegument and associated structures of the cercaria of Schistosoma mansoni. PMID- 4323979 TI - [The influence of intra- and extracellular electrolyte metabolism on blood vessel reactability]. PMID- 4323981 TI - [The detection of enterovirus in water with the aid of membrane filters]. PMID- 4323982 TI - [Phospholipids in the liver of rats during chronic poisoning with CCl4]. PMID- 4323984 TI - Polymyxin B in the treatment of Klebsiella pneumoniae meningoventriculitis. Intraventricular and intrathecal administration. PMID- 4323983 TI - A survey of acute toxicity of cycads and mortality rate from cancer in the Miyako Islands, Okinawa. PMID- 4323985 TI - Poland's syndrome. PMID- 4323986 TI - [Specific surface leukemic antigen and malignization of cells in mice of CC57BR strain innoculated with Mazurenko virus]. PMID- 4323987 TI - [Effect of experimental thyrotoxicosis on development of compensatory adrenal hypertrophy]. PMID- 4323988 TI - [Cytochrome oxidase activity in the epithelium of villi of the jejunum in mice in radiation sickness and during the radioprotective action of cyanide]. PMID- 4323989 TI - [Chemosensitivity of dorsal root fibers to potassium ions and the hypothesis of the peripheral mechanism of pain]. PMID- 4323990 TI - [Effect of hypercoagulation on the lifespan of erythrocytes labelled with Cr5l]. PMID- 4323992 TI - [Effect of total and subtotal thyroidectomy on the growth of transplanted multiform glioblastoma of rat cerebellum]. PMID- 4323991 TI - [Inhibition of the adrenal gland function by acetylated derivatives of adrenocorticotropic hormone]. PMID- 4323993 TI - [Viral hemangiomatosis of mice]. PMID- 4323994 TI - Participation of central noradrenergic neurons in arterial baroreceptor reflexes in the rabbit. PMID- 4323995 TI - Effects of intrahypothalamic and intraventricular norepinephrine and 5 hydroxytryptamine on hypothalamic blood flow in the conscious rabbit. PMID- 4323996 TI - [Importance of radiophosphorus test in the framework of melanoma diagnosis]. PMID- 4323997 TI - [Comparative quantitative and histotopochemical examinations on phosphomonoesterases in the clinical unaffected skin of psoriatics]. PMID- 4323998 TI - [Zoonoses]. PMID- 4324000 TI - [Histochemical occurrence of enzymes in sensory ganglia; exhibited on ganglion semilunare of domestic cattle. I. Oxidoreductases]. PMID- 4323999 TI - Inhibitory sensitive, inhibitory resistant and substrate specific phosphatases in the vertebrate adrenal medulla. PMID- 4324001 TI - [Glomus tumors of the skin]. PMID- 4324002 TI - [Aflatoxin production by Aspergillus flavis Link strains of different origin]. PMID- 4324003 TI - [Phasic changes in heart rate following acoustic stimuli during natural human sleep]. PMID- 4324004 TI - The effect of polarizing current on action potential and transmitter release in crayfish motor nerve terminals. PMID- 4324005 TI - Pancreatic problems. 2. Chronic pancreatitis and pancreatic tumors. PMID- 4324006 TI - [Interstitial and diffuse pulmonary fibrosis]. PMID- 4324007 TI - [Petit mal status: light epileptic attacks]. PMID- 4324008 TI - [Some questions on the effect of ionizing radiation on the endocrine system and its part in radiation syndrome]. PMID- 4324009 TI - [Initial experiences with perlingual lymphography. II. Animal experiment studies- testing of a new emulsion of lipiodol (Livo)]. PMID- 4324010 TI - [Surgery of bilateral Wilm's tumor]. PMID- 4324011 TI - Aspergillosis: a review and case report. PMID- 4324012 TI - Surgical grand rounds from the University of Mississippi Medical Center. Tumor of the middle ear. PMID- 4324013 TI - Secondary systemic amyloidosis: analysis of underlying disorders. PMID- 4324014 TI - Pseudomyxoma peritonei due to mucinous adenocarcinoma of the urachus. PMID- 4324015 TI - Recovery of the kinetic and tonic components in M-wave after repetitive stimulation. PMID- 4324016 TI - [Clinico-cytological diagnosis of soft-tissue sarcoma in children]. PMID- 4324017 TI - Penoposthitis associated with infectious bovine rhinotracheitis-infectious pustular vulvovaginitis (I.B.R.-I.P.V.) virus in a stud of bulls. PMID- 4324018 TI - [Ultrastructure of juvenile nasopharyngeal fibroma]. PMID- 4324019 TI - The effect of ACTH and cortisone on the incorporation of S35 (sulphate) into the mucous cells of the rat stomach. PMID- 4324020 TI - [A large pediculate liver cell adenoma]. PMID- 4324021 TI - Familial hepatoma with hepatitis-associated antigen. PMID- 4324022 TI - Metastatic insulinoma treated with streptozotocin. PMID- 4324023 TI - Phosphoribosylpyrophosphate in man: biochemical and clinical significance. PMID- 4324024 TI - Australia antigen: a genetic basis for chronic liver disease and hepatoma? PMID- 4324025 TI - Streptozotocin and metastatic insulinoma. PMID- 4324028 TI - [Pathomorphological characteristics of respiratory diseases in children]. PMID- 4324026 TI - Spectrophotometric determination of the intermediates of glycolysis and the pentose phosphate cycle in Chlorella cells. PMID- 4324027 TI - Studies on nitrate reductase from Cyanidium caldarium. PMID- 4324029 TI - [Involvement of the respiratory organs in viral respiratory infections]. PMID- 4324030 TI - Acetylcholine and the synaptic transmission of specific impulses to the visual cortex. PMID- 4324031 TI - Acetylcholine and the synaptic transmission of non-specific impulses to the visual cortex. PMID- 4324032 TI - Comparative neuropathology of ageing. Studies on the brains of 47 species of vertebrates. PMID- 4324033 TI - Eye movement potentials in the oculomotor and visual systems of the cat: a comparison of reserpine induced waves with those present during wakefulness and rapid eye movement sleep. PMID- 4324034 TI - The effect of 5-HTP on the static fusimotor activity and the tonic stretch reflex of an extensor muscle. PMID- 4324035 TI - Sodium-potassium-ATPase activity of normal and virally transformed hamster astroglia grown subcutaneously. PMID- 4324036 TI - [Control of the hypothalamic-hypophyseal-adrenal cortex regulatory zone with ACTH and the metopirone test in long-term glucocorticoid therapy]. PMID- 4324037 TI - [Possibility of the complex use of industrial and agricultural waste waters in an ore-concentrating plant]. PMID- 4324039 TI - [Nervous tumors of the nasal fossae. Anatomo-pathological study]. PMID- 4324038 TI - Major hepatic resections in infancy and childhood. AB - Nineteen infants and children who had hepatic lobectomy or segmental resection of the liver for tumours are described. Fourteen had lobectomy for malignant tumours but only three survived for more than a year. Four of the five patients who had resections for hamartomas have survived for 18 months or more. The main problem encountered at operation was haemorrhage, which was responsible for the entire operative mortality of 31%. A transient disturbance of liver function occurred after operation in both patients who had preoperative radiotherapy. PMID- 4324040 TI - [Electron microscopic studies of tubercle bacilli treated with kanamycin]. PMID- 4324041 TI - [Clinical study on tuberactinomycin, a new antibiotic]. PMID- 4324042 TI - Inhibition of herpes virus adsorption by two fractions obtained from commercial protamine sulfate. PMID- 4324043 TI - [Early recognition of malignant breast tumors]. PMID- 4324044 TI - [Unusual fulminating case of pancreatic insulinoma]. PMID- 4324045 TI - [A case of primary tubal carcinoma associated with uterus duplex and vagina septa]. PMID- 4324046 TI - [Modifications by some vasoactive drugs of the effects of an encephalic ischemic anoxia in cats]. PMID- 4324047 TI - [Action of chlorpromazine on the functioning of the hypothalamo-hypophyseal system in human]. PMID- 4324048 TI - [Similarity of changes in liver cell enzyme activity due to the immediate effects of carcinogens and after malignization]. PMID- 4324049 TI - [Peculiarities of a cold variant of foot-and-mouth disease virus (type O)]. PMID- 4324050 TI - [Indication of virus of equine infectious anemia]. PMID- 4324051 TI - [Bronchial carcinoid. Apropos of 5 cases, one of which was a carcinoid syndrome]. PMID- 4324052 TI - [2 cases of Langerhans adenoma]. PMID- 4324053 TI - [Diseases of the pancreas, liver and spleen in the light of selective arteriography]. PMID- 4324054 TI - [Epithelioma of the pharyngeal walls of the rhino-, oro- and the hypopharynx (tonsillar and pyriform sinus regions excluded)]. PMID- 4324055 TI - Dermatomyositis. Electron microscopic, immunologic, and tissue culture studies of paramyxovirus-like inclusions. PMID- 4324056 TI - Mossbauer spectroscopy of mesohaem and protohaem myoglobins and their fluoride complexes. PMID- 4324057 TI - The magnetic susceptibility of the oxidized and reduced iron-sulfur proteins adrenodoxin and putidaredoxin. PMID- 4324058 TI - Dye-sensitized photo-inactivation of collagenase A. PMID- 4324059 TI - Further demonstration that cysteine reacts with the metal component of collagenase. PMID- 4324060 TI - Cytomegalovirus infection in blood donors--a prospective study. PMID- 4324061 TI - [In vivo study of DNA and RNA kinetics of various normal and cancerous human cell populations]. PMID- 4324063 TI - Alveolar cell carcinoma of the lung: a case presentation at the weekly thoracic conference at the Mayo Clinic. PMID- 4324062 TI - [Demonstration of lectin receptor sites on the membrane of human tumoral cells]. PMID- 4324065 TI - Determination of serum lactic dehydrogenase isoenzymes by use of the "Diagnostest" cellulose acetate electrophoresis system. PMID- 4324064 TI - Ethanol in brain, as assayed by microfluorometry. PMID- 4324066 TI - [Recurrent spontaneous severe hypoglycemia associated with insulin-unstable diabetes: prolonged insulin interruption]. PMID- 4324067 TI - [Salivary gland tumors in the German Democratic Republic during 1955-1958. 1]. PMID- 4324068 TI - Factors involved in fatty acyl CoA desaturation by fungal microsomes. The relative roles of acyl CoA and phospholipids as substrates. PMID- 4324069 TI - A method of obtaining a suspension of intact parenchymal cells from adult rat liver. PMID- 4324070 TI - Activation of myocardial adenyl cyclase by histamine in guinea pig, cat, and human heart. AB - Histamine has positive inotropic and chronotropic effects on the heart which are not abolished by beta adrenergic-blocking agents. Since the positive inotropic and chronotropic effects of other hormones on the heart are thought to be mediated by cyclic 3',5'-AMP, we examined the effect of histamine on adenyl cyclase in particulate preparations of guinea pig, cat, and human myocardium. Histamine at the peak of its dose-response curve, 3 x 10(-4)moles/liter, produced approximately a 300% increase in cyclic 3',5'-AMP accumulation in the guinea pig, 60% in the cat, and 90% in the human heart particles. Half-maximal activity for the histamine mediated activation of adenyl cyclase in the guinea pig was 9 x 10( 6)moles/liter, almost identical with that observed for norepinephrine in the same preparation. DL-Propranolol, 1 x 10(-5)moles/liter, did not abolish the activation of adenyl cyclase produced by histamine but did abolish the activation produced by norepinephrine. In contrast, diphenhydramine hydrochloride, Benadryl, 8 x 10(-5)moles/liter, abolished the activation of adenyl cyclase by histamine but not that produced by norepinephrine. These data suggest that there are at least two receptor sites in guinea pig heart mediating the activation of adenyl cyclase, one responsive to histamine, the other to norepinephrine. In addition, combined maximal doses of histamine and norepinephrine produced completely additive effects on the activation of adenyl cyclase, which suggests that at least two separate adenyl cyclase systems are present in the heart, each responsive to one of these hormones. However, definitive proof would require physical separation of the two enzymes. PMID- 4324071 TI - Excitation-contraction coupling in heart. VII. Calcium accumulation in subcellular particles in congestive heart failure. AB - The ability of heavy microsomes and mitochondria, isolated from the control and failing hearts of genetically dystrophic hamsters (BIO 14.6 strain), to accumulate calcium was examined. The rate and extent of energy-linked calcium binding (in the absence of oxalate) by the heavy microsomes of the failing heart were markedly depressed. The calcium uptake (in the presence of 5 mM oxalate) by the heavy microsomes of the failing heart was similar to that of the control heart. On the other hand, both the rate and extent of energy-linked calcium binding (in the absence of Pi and succinate) and calcium uptake (in the presence of 4 mM Pi and 5 mM succinate) by mitochondria were greatly reduced in the failing heart in comparison to the control. No difference in the total adenosine triphosphatase activities (Ca(++)-Mg(++) stimulated) of heavy microsomes or mitochondria was observed between the control and failing hearts. These results indicate an abnormality of subcellular membranes of the failing heart to bind calcium and support the growing conviction concerning the defective "calcium pump" as a molecular abnormality associated with a moderate degree of congestive heart failure. PMID- 4324073 TI - Relationship between renin and intrarenal hemodynamics in hemorrhagic hypotension. AB - In order to investigate the possible role of the renin-angiotensin system in the regulation of intrarenal hemodynamics in hemorrhagic hypotension (HH), seven mongrel dogs have been studied under the following conditions: (a) Control, (b) HH (mean arterial pressure 70 mm Hg), and (c) HH + alpha adrenergic blockade by phenoxybenzamine (HH + POB). The following parameters were obtained for the right kidney: Intrarenal distribution of blood flow and local blood flow rates ((133)Xe washout technique); total renal blood flow (RBF) on the basis of the clearance and extraction ratio of PAH and the arterial hematocrit; plasma renin concentrations in the renal artery and vein by the method of Boucher and his associates; and renin release into the renal circulation. Alpha adrenergic blockade reverted the typical redistribution of intrarenal blood flow observed under HH. In hemorrhage, arterial and venous renin concentrations increased by a factor of 3.4 and 4.8 respectively. A further small increase was observed during HH + POB with the respective factors increasing to 4.8 and 5.3, as compared with control values. The renin release into the circulation increased by a factor of 1.2 in HH and 4.0 in HH + POB. Whereas in HH there seemed to be a relationship between increased renin concentrations or renin release, and the redistribution of blood flow, no such correlation was found during alpha-adrenergic blockade. From these observations it is concluded that renin alone is unable to maintain the typical redistribution of RBF seen during hemorrhage. Circumstantial evidence points to a permissive role of the renin-angiotensin system in the pathogenesis of the patchy cortical hypoperfusion caused by sympathoadrenergic mechanisms during hemorrhagic hypotension. PMID- 4324072 TI - Inorganic pyrophosphate in plasma in normal persons and in patients with hypophosphatasia, osteogenesis imperfecta, and other disorders of bone. AB - An isotope dilution method, using (32)P-labeled pyrophosphate, has been developed for the measurement of inorganic pyrophosphate (PP(1)) in human plasma. The specificity of the method was better than 90% as assessed by elution patterns during ion-exchange chromatography, by paper chromatography, and by incubation with inorganic pyrophosphatase. The 99% confidence limits for a single estimation of plasma PP(1) was +/-13%. There were no differences in plasma PP(1) between men and women, but the values in young people (0-15 yr) were slightly higher than in older people. The mean concentration (+/-SE) of PP(1) in the plasma of 73 men and women was 3.50 +/-0.11 mumoles/liter (0.217 +/-0.007 mug P/ml) and the normal range (99% limits) was 1.19-5.65 mumoles/liter (0.074-0.350 mug P/ml). It has been suggested that PP(1) may be important in calcium metabolism because PP(1) can prevent the precipitation of calcium phosphates in vitro and in vivo, and can slow the rates at which hydroxyapatite crystals grow and dissolve. Plasma PP(1) was therefore measured in several disorders of bone. Normal values were found in osteogenesis imperfecta, osteopetrosis, "acute" osteoporosis, and primary hyperparathyroidism. Plasma PP(1) was invariably raised in hypophosphatasia. The excess of PP(1) in plasma might be the cause of the defective mineralization in hypophosphatasia and the function of alkaline phosphatase in bone may be to act as a pyrophosphatase at sites of calcium deposition. PMID- 4324074 TI - [Lactate dehydrogenase (LDH) and its isoenzymes--how to read its figures]. PMID- 4324075 TI - Recent advances in the management of burns. PMID- 4324076 TI - [The numerous uses of collagenase]. PMID- 4324077 TI - [The liver and spleen in cirrhotic patients after portocaval derivation]. PMID- 4324078 TI - Chemotherapy of residual disease in solid tumours. PMID- 4324079 TI - [Several aspects of viral embryonal and fetal diseases]. PMID- 4324080 TI - [Sinusitis during para-influenza and Hong Kong 68 influenza A2]. PMID- 4324082 TI - [Investigations concerning ACTH storage dynamics in the pituitary gland of stressed and ACTH-treated rats]. PMID- 4324081 TI - [Production of potent antiserums agiinst ACTH and their application in radioimmunoassay]. PMID- 4324083 TI - Ultrastructure and hormone distribution of the human corticotrophic anterior pituitary cell under normal conditions, in corticotrophic adenoma and in exogenous hypercortisolism. PMID- 4324084 TI - [Excretion of steroid hormones in Turner's syndrome]. PMID- 4324085 TI - [Some aspects of the pharmacology of cholinergic synapses and its central significance]. PMID- 4324087 TI - Recovery of the transmitter content in uterine adrenergic nerves after pregnancy. PMID- 4324086 TI - Current cancer chemotherapy in obstetrics and gynecology. PMID- 4324088 TI - Sorptive dusts for pest control. PMID- 4324089 TI - Bronchoesophagology. PMID- 4324090 TI - Influence of the phosphodiester linkage (3'-5', 2'-5', and 5'-5') on the conformation of dinucleoside monophosphate. PMID- 4324091 TI - L'adenylyl-(3'-5')-L-adenosine and L-adenylyl-(2'-5')-L-adenosine. PMID- 4324092 TI - Phosphorescence studies of environmental heterogeneity for tryptophyl residues in proteins. PMID- 4324093 TI - Stoichiometric aspects of uncoupling of oxidative phosphorylation by a salicylanilide derivative. PMID- 4324094 TI - Arrangement of fatty acyl groups in phosphatidylethanolamine from a fatty acid auxotroph of Escherichia coli. PMID- 4324096 TI - Effects of alkali ions on myosin conformation. PMID- 4324095 TI - Action of venom phosphodiesterase on aminoacyl-tRNA from Escherichia coli. PMID- 4324097 TI - [Results of 7 years' activity of a hospital virology laboratory (1963-1970)]. PMID- 4324099 TI - [Use of the absorption spectroscopy in the analysis of drugs from the group of estrogens and their synthetic substitutes]. PMID- 4324100 TI - [Impulse activity of sinus and diaphragmatic nerves in asphyxia]. PMID- 4324101 TI - [Skull tomography in trans-maxillary oblique projection. A simple and versatile setting]. PMID- 4324102 TI - [Histological and histochemical study of the placenta in biologically prolonged pregnancy]. PMID- 4324103 TI - [Kraurosis vulvae. Clinical experiment on the hormonal influence]. PMID- 4324104 TI - [Clinical pathology of sialadenitis and sialadenosis]. PMID- 4324105 TI - Direct immunofluorescent studies of infection with respiratory syncytial virus. PMID- 4324106 TI - [Comparative biochemistry of cyctochrome c and evolution of organisms]. PMID- 4324108 TI - [Primary aldosteronism: facts and suppositions]. PMID- 4324107 TI - [Psychiatric prognosis of infantile spasms treated by ACTH or corticoids. Statistical analysis of 78 cases followed for more than one year]. PMID- 4324109 TI - [Immunotherapy of neoplasms]. PMID- 4324110 TI - Catalysis of methaemoglobin reduction by erythrocyte cytochrome B5 and cytochrome B5 reductase. PMID- 4324111 TI - Turning on the lactose genes. PMID- 4324112 TI - Regulation of lac mRNA synthesis in a soluble cell-free system. PMID- 4324113 TI - Regulation of lac transcription in antibiotic-treated E. coli. PMID- 4324114 TI - Serial passage of avian tumour viruses in ducks and Japanese quail. PMID- 4324115 TI - Adventitious viruses in cell cultures. PMID- 4324116 TI - [Physiological properties of ubiquinone]. PMID- 4324117 TI - [Testicular phospholipid metabolism in rats during oxygen starvation]. PMID- 4324118 TI - [The phospholipid composition of rabbit serum beta-lipoproteins]. PMID- 4324119 TI - [Isolation and various properties of Cl. perfringens hyaluronidase]. PMID- 4324120 TI - [The effect of ovarian steroids on glucose-6-phosphatase activity and sodium and potassium concentration in the renal tissue of female rats]. PMID- 4324121 TI - [Preparation of H3-deoxyadenosine, H3-adenosine and H3-adenosine-3',5' cyclophosphate by the H-3-20 proton exchange method]. PMID- 4324122 TI - [The nature of the basic components of the orthodromal potential and inhibition of secondary neurons of the frog olfactory bulb]. PMID- 4324123 TI - [Regulation of the function of the frontal lobe of the pituitary gland and of the peripheral glands excreting into the blood]. PMID- 4324124 TI - Cyclic AMP as a mediator of hormonal metabolic effects in brown adipose tissue. PMID- 4324125 TI - Intracellular distribution of phospholipases in the rat pancreas. PMID- 4324126 TI - Quantitative estimation of secretion and reuptake of adrenergic transmitter in the rabbit heart. PMID- 4324127 TI - Sleep and other behaviours of the red kangaroo (Megaleia rufa). PMID- 4324128 TI - [The action in vitro of melatonine on hormonosynthesis in the adrenal cortex of the rat]. PMID- 4324129 TI - [Effect of thyrocalcitonin on the assimilation of calcium in food ingested with vitamin D3 or sodium acid carbonate]. PMID- 4324130 TI - [Kinetic study of corticosterone production by the adrenal glands of rats in vitro. Influence of Ca plus, plus ions and certain inhibitors of protein synthesis on the action of ACTH]. PMID- 4324131 TI - [Pathological anatomy of endogenous uveitis]. PMID- 4324132 TI - Copper deficiency in the rat. Effect of synthesis of phospholipids. PMID- 4324133 TI - Cytochrome b5 and P-450 in liver cell fractions. PMID- 4324134 TI - Studies on the mechanism of hemolysis by acyl carnitines, lysolecithins and acyl cholines. PMID- 4324135 TI - Identification of a phospholipase A1 in plasma membranes of rat liver. PMID- 4324136 TI - Stimulation of the phosphatase activity of(Na+, K+)-ATPase preparations by ouabain. PMID- 4324138 TI - [A new highly active vitamin D 3 metabolite]. PMID- 4324137 TI - [Role of transcutaneous radiotherapy in the treatment of pituitary adenoma]. PMID- 4324139 TI - Electromyography (EMG) in surgery of the hand. PMID- 4324141 TI - [Functional morphology and cytochemistry of adrenal cortex in rats with audiogenic "reflex" epilepsy]. PMID- 4324140 TI - Recording of proprioceptive muscle afferents in man by various disorders of tendon reflex. PMID- 4324142 TI - [Neuron activity in the somatosensory area of the rat cerebral cortex subjected to the action of static electric fields]. PMID- 4324143 TI - [Participation of the cervical section of the sympathetic nervous system and the carotid tubercles in catecholamine secretion during stimulation of the vagus nerve]. PMID- 4324144 TI - [Effect of some pituitary hormones on renal hemodynamics]. PMID- 4324145 TI - [Histochemical study of "lichen amyloidosus"]. PMID- 4324146 TI - Spontaneous recovery and sleep. PMID- 4324147 TI - [Hypoglycemic nesidioblastoma. A case in an older person]. PMID- 4324148 TI - [Case of early stomach cancer of the IIc type and maxillary cancer]. PMID- 4324149 TI - [Case of well differentiated hepatocellular carcinoma in the aged--enzyme histochemical studies]. PMID- 4324150 TI - [Course of herpes simplex virus infection in mice in the course of cortisone administration]. PMID- 4324151 TI - [Effect of magnesium chloride on hemagglutination and infective properties of enteroviruses]. PMID- 4324152 TI - [HL-A system and human diseases]. PMID- 4324153 TI - [Peripheral neuropathies during hyperthyroidism]. PMID- 4324155 TI - [Composition of Ivory Coast nuoc-mam]. PMID- 4324154 TI - [Nuoc-mam from salt-water fish of the Ivory Coast]. PMID- 4324156 TI - [Synoviosarcoma. (Presentation of a case)]. PMID- 4324157 TI - [The motor analyzer and its place in the system of analyzers]. PMID- 4324158 TI - [interhemispheric interaction in rats during changes of the time interval between monocular stimuli]. PMID- 4324159 TI - Reduction of extrusion and infection following episcleral silicone implants and cryopexy in retinal detachment surgery. PMID- 4324160 TI - Fine structure of the blue-green phycobiont and its relation to the mycobiont in two Gonohymenia lichens. PMID- 4324162 TI - Metabolism of progesterone in the newborn. PMID- 4324161 TI - Fructose-1,6-diphosphatase, phosphofructokinase and glucose-6-phosphate dehydrogenase from fermenting and non fermenting yeasts. PMID- 4324163 TI - Dream content study in chronic schizophrenics and normals by REMP-awakening technique. PMID- 4324165 TI - Studies on seeds. IV. Lipid composition of bean cotyledon vesicles. AB - Lipid content has been determined for two types of lipid-rich vesicles isolated from bush bean cotyledon at 24 hr of germination. The larger, nonassociating vesicles are four to six times richer in triglyceride than the smaller vesicles which associate strongly among themselves, as well as with smooth membranes in the cell. The larger vesicles contain about 640 micromoles of phospholipid per gram of protein, while the smaller vesicles have only one-half to two-thirds as much phospholipid per gram of protein. The ratio of individual phospholipids in both kinds of vesicles is close to 20% phosphatidylethanolamine, 60% phosphatidylcholine, and 20% phosphatidylinositol. The fatty acid composition of all phospholipids is similar, and quite different from that of triglyceride, which contains twice as much linolenic acid and less than one-fourth as much palmitic acid. Pea cotyledon has quantitatively the same lipid content as bean cotyledon. PMID- 4324166 TI - Vacuoles in the embryonic chick corneal epithelium, an epithelium which produces collagen. PMID- 4324167 TI - [Tumor of pulmonary blastema]. PMID- 4324168 TI - Effects of lateral inhibition on fluctuations of the impulse rate. AB - Inhibition from neighboring eccentric cells has an effect on the variability of firing of a given eccentric cell. The reduction in the average impulse rate which is caused by inhibition decreases the variance of the impulse rate. However, this reduction of the average rate increases the coefficient of variation of the impulse rate. Inhibitory synaptic noise should add to the low frequency portion of the variance spectrum of the impulse rate. This occurs because of the slow time course of inhibitory synaptic potentials. As a consequence, inhibition decreases the signal-to-noise ratio for low frequency modulated stimuli. PMID- 4324169 TI - [Value of duroliopaque in ventriculography]. PMID- 4324170 TI - [A case of chemodectoma (nonchromaffin paraganglioma) of the bladder]. PMID- 4324171 TI - [17-alpha-hydroxylase deficiency]. PMID- 4324172 TI - [Aldosteronism--past, present and future]. PMID- 4324173 TI - [Menstrual cycle, pregnancy, and aldosterone]. PMID- 4324174 TI - [Hypertension caused by oral contraceptives]. PMID- 4324175 TI - [Glucocorticoid responsive aldosteronism: our pediatric cases and presentation of concepts]. PMID- 4324176 TI - [Juxtaglomerular cell tumor and aldosterone-secreting renal tumor]. PMID- 4324177 TI - [Liver cirrhosis]. PMID- 4324179 TI - Recovery time for alcoholics after prolonged alcohol intoxication. PMID- 4324178 TI - [Congestive heart failure and aldosterone]. PMID- 4324180 TI - Nystagmus arousal during the latent period of caloric nystagmus. PMID- 4324181 TI - Salivary gland tumors in ectopic sites. PMID- 4324182 TI - Pancreatitis associated with pancreatic carcinoma: a study of 26 cases. PMID- 4324183 TI - [Virus induced oncogenesis]. PMID- 4324184 TI - Fine structure of mammary adenoid cystic carcinoma. PMID- 4324185 TI - [Evaluation of the concept of dysgenesis in muscular tumors. (Clinical and anatomopathological study)]. PMID- 4324186 TI - [Therapy of recurrent Herpes simplex]. PMID- 4324187 TI - Comparison between beta 1-24 corticotrophin, DW-75 (Sandoz) and natural corticotrophin in normal adults pretreated with dexamethasone. PMID- 4324188 TI - Characteristics of the formation and conversion of androgenic hormones in the rat adrenal gland. PMID- 4324189 TI - [Antiviral properties of fucidin]. PMID- 4324190 TI - [Thin layer silica gel chromatography of penicillins. Separation of phenoxymethylpenicillin in its inactivation products]. PMID- 4324192 TI - Comparison of microtiter procedures with the plaque technique for assay of vesicular stomatitis virus. AB - This paper describes a microprocedure for the tissue culture assay of vesicular stomatitis virus (VSV) and compares the sensitivity of the method with the conventional plaque assay of viral concentration. Microtiter and plaque assay methods were used in titrations, neutralization tests, and thermoinactivation studies with this virus in chick embryo fibroblasts (CEF) and L, HeLa, and PK cell lines. Titration experiments with VSV by the microtiter procedure on preformed monolayers were significantly more sensitive than the plaque assay (P = 0.05). The results of the neutralization tests and thermoinactivation studies also showed greater ability to detect residual virus by the microtiter procedure (P = 0.10). In addition, the microtiter procedure was simpler, less costly, and more rapid than the plaque assay. PMID- 4324191 TI - Interferon-inducing characteristics of MM virus. AB - Interferon induction by MM virus in mice and in L cells was studied. In mice the virus readily induced interferon. The time of appearance was dose-dependent. A large virus dose induced interferon by 4 hr, whereas a small dose resulted in interferon production which paralleled virus replication 24 hr after infection. In L cells the interferon-inducing capacity of the virus was rapidly destroyed by ultraviolet light irradiation. Heating (56 C) of the virus, on the other hand, greatly increased its ability to induce interferon. Interferon production could also be increased by prior treatment of the cells with homologous interferon (priming). The increase in interferon production after priming was dependent on the concentration of interferon used for priming, the length of interferon treatment, and the multiplicity of infection. It is suggested that MM virus might be useful for the further study of the mechanisms involved in the production and action of interferon. PMID- 4324193 TI - Virus in water. I. A preliminary study on a flow-through gauze sampler for recovering virus from waters. AB - A preliminary study was carried out on evaluating a flow-through gauze sampler for its efficiency in recovering virus from both fresh and seawater. An attenuated type 1 poliovirus was used as the working model. When tap water was sampled, the amounts of virus adsorbed by the gauze pads were very small, about 2% of the total number of virus particles flowing through the device. The virus adsorption and recovery increased to 15 to 19% when seawater was sampled. Addition of NaCl to tap water produced a much better effect on virus adsorption and recovery by this device, i.e., 47% of the total virus particles in each sample. The best viral elution from the pads was obtained by using buffer solution of pH 8.0 to 9.0 containing a small amount of animal serum. Repeated elutions from the pads were necessary to recover the most virus although the first eluate contained approximately 50% of the adsorbed virus. Further development of this device appears warranted, because of (i) the simplicity of the procedure, (ii) its capability of sampling large volume of water, (iii) the low cost of collecting samples, and (iv) the feasibility of obtaining a rough quantitative assessment of viral pollutants in water examined. PMID- 4324194 TI - Analysis of Clostridium botulinum toxigenic types A, B, and E for fatty and carbohydrate content. AB - Lyophilized, 48-hr log-phase vegetative cells were extracted with chloroform methanol (2:1, v/v) and ethanol-ether (3:1, v/v) and then saponified with methanolic KOH. Gas-liquid chromatography of the methyl esters of extractable fatty acids revealed distinctive "pattern profiles" of Clostridium botulinum toxigenic types "A," "B," and "E." C. perfringens type "A" and Escherichia coli strain "B" were also studied in a similar manner and were found to give pattern profiles which were distinct even from those obtained for the C. botulinum microorganisms. Amino sugar content of the five microorganisms was determined by using a Beckman amino acid analyzer. The molar ratio of glucosamine to that of galactosamine was found to be of further assistance in distinguishing the individual microorganisms. PMID- 4324195 TI - New quantitative, qualitative, and confirmatory media for rapid analysis of food for Clostridium perfringens. AB - A selective and differential medium, Shahidi-Ferguson Perfringens agar (SFP agar), and a confirmatory medium, lactose-motility agar (LM agar), were developed for the enumeration and identification of Clostridium perfringens in foods. These media provide a rapid, specific, and direct diagnosis of C. perfringens. SFP agar contains sodium metabisulfite and ferric ammonium citrate to demonstrate H(2)S production and egg yolk to demonstrate lecithinase production by C. perfringens. On SFP agar, C. perfringens produces black colonies, 2 to 3 mm in diameter, surrounded by zones of opaque precipitate. The typical colonies are confirmed on LM agar. Enumeration and identification are completed within 48 hr. All of the ingredients of SFP agar are stable to heat and storage conditions. SFP agar also contains two antibiotics, kanamycin and polymyxin B, which are inhibitory to many bacteria commonly occurring in foods. A comparative study of SFP agar and noninhibitory media showed that SFP agar did not inhibit any of the 16 strains of C. perfringens tested. Recovery of C. perfringens added to foods averaged 90.6% for SFP agar as compared with 69.8% for sulfite polymyxin-sulfadiazine (SPS) agar (BBL) and 60.2% for SPS agar (Difco). The colonies on the SFP agar, were much larger and were consistently black. Of 464 food samples tested, C. perfringens was found in 27 samples with SFP agar and in 5 samples with SPS agar (Difco), with a recovery ratio considerably higher on SFP agar. SFP agar is a more specific presumptive medium for the enumeration of C. perfringens and in conjunction with LM agar should save considerable time, effort, and materials toward the final identification of the species. PMID- 4324196 TI - Antibodies to Epstein-Barr virus in a Burkitt's lymphoma cell line in Taiwan monkeys (Macaca cyclopis). AB - The prevalence of Taiwan monkeys with antibodies to Epstein-Barr virus, as detected by the indirect immunofluorescence technique, was lower than that of healthy persons in Taiwan. PMID- 4324198 TI - [Sialographicaly detectable parotid gland changes in mucoviscidosis and cytomegaly]. PMID- 4324197 TI - [Plasma renin activity and pregnancy]. PMID- 4324199 TI - Childhood thyroid carcinoma. PMID- 4324200 TI - Considerations in the development of a predictive system for cancer chemotherapy. PMID- 4324201 TI - Studies on heat-inactivation of pyrogen from Escherichia coli. PMID- 4324202 TI - Carbon monoxide binding studies of cytochrome a3 hemes in intact rat liver mitochondria. PMID- 4324203 TI - Inside-outside transitions of phospholipids in vesicle membranes. PMID- 4324205 TI - Magnetic resonance studies of the role of the divalent cation in the mechanism of yeast aldolase. PMID- 4324204 TI - Characterization of adenyl cyclase from the testis of Chinook salmon. PMID- 4324206 TI - PK of the lysine amino group at the active site of acetoacetate decarboxylase. PMID- 4324207 TI - Effect of substrate on the lipids of the hydrocarbon-utilizing Mycobacterium vaccae. PMID- 4324208 TI - Fine structure of the fungus Metarrhizium anisopliae infecting three species of larval Elateridae (Coleoptera). IV. Development within the host. PMID- 4324209 TI - [Scintigraphic studies of the lung perfusion changes following lymphography with oily contrast media]. PMID- 4324210 TI - Difference of RNA population between normal liver and hepatoma AH-130. PMID- 4324211 TI - [Cytochemical findings in panmyelopathy]. PMID- 4324212 TI - Multiple forms of anthranilate synthetase-anthranilate 5 phosphoribosylpyrophosphate phosphoribosyltransferase from Salmonella typhimurium. PMID- 4324213 TI - Studies on the respiratory chain-linked nicotinamide adenine dinucleotide dehydrogenase. XXII. Rhein, a competitive inhibitor of the dehydrogenase. PMID- 4324215 TI - Regulation and mechanism of phosphoribosylpyrophosphate synthetase. 3. Kinetic studies of the reaction mechanism. PMID- 4324214 TI - Regulation of galactokinase synthesis by cyclic adenosine 3',5'-monophosphate in cell-free extracts of Escherichia coli. PMID- 4324216 TI - Cytidine triphosphate polymerase activity associated with isolated chromatin of sugar beets. PMID- 4324217 TI - Uridine diphosphate glucose pyrophosphorylase. 3. Catalytic mechanism. PMID- 4324218 TI - Structural analysis of nucleolar precursors of ribosomal ribonucleic acid. Polypurine sequences in nucleolar 28 S ribonucleic acid of Novikoff hepatoma ascites cells. PMID- 4324219 TI - Adenosine 3',5'-monophosphate-dependent and -independent protein phosphokinase isoenzymes from mammary gland. PMID- 4324221 TI - Glycosyltransferase activities in normal and polyoma-transformed BHK cells. PMID- 4324220 TI - Effects of guanosine 3',5'-monophosphate on the perfused rat liver. PMID- 4324222 TI - Studies of cardio-regulation in the cockroach, Periplaneta americana. PMID- 4324223 TI - [Transformation of human chorionic cell by SV40 and its transplantation into the hamster uterus]. PMID- 4324224 TI - Skin potential activities and their regional differences during normal sleep in humans. PMID- 4324225 TI - Circulating proinsulin-like material in patients with functioning insulinomas. PMID- 4324226 TI - Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 18-1971. PMID- 4324227 TI - A serologic study of cytomegalovirus infections associated with blood transfusions. PMID- 4324228 TI - Hepatoma and peliosis hepatis developing in a patient with Fanconi's anemia. PMID- 4324229 TI - Field M: Intestinal secretion: effect of cyclic AMP and its role in cholera. PMID- 4324230 TI - [Primary cancer of the liver associated with chronic schistomiasis japonica]. PMID- 4324231 TI - Infection of mammalian unfertilized and fertilized ova with oncogenic viruses. PMID- 4324232 TI - [The cancer-risk in man from synthetic sweetening agents]. PMID- 4324233 TI - Use of in vivo magnification renal arteriography to study cadmium effects on vasoactive responses. PMID- 4324234 TI - [Corticoid therapy]. PMID- 4324235 TI - [Clarification of a hypertension]. PMID- 4324236 TI - Characteristic features of tumours in children. PMID- 4324237 TI - [Etiological structure of diarrhea in young children]. PMID- 4324238 TI - [Syringo-epithelioma of the skin]. PMID- 4324239 TI - [Sex chromatin in malignant tumors of the breast in patients subjected to preoperative irradiation]. PMID- 4324240 TI - Characterization of DNA isolated from metaphase chromosomes of cells containing Epstein-Barr virus. PMID- 4324241 TI - Studies on nucleic acids of living fossils. I. Isolation and characterization of DNA and some RNA components from the brachiopod Lingula. PMID- 4324242 TI - Nature of the nuclease activity prevalent in Mycobacterium smegmatis during in vitro amino acid incorporation. PMID- 4324243 TI - [Inhibitory actions of pregnenolone on cancerization of the liver, and favourable to the development of neoplasms of the interstitial gland of the testis, in rats poisoned by para-dimethylaminoazobenzene (DAB)]. PMID- 4324244 TI - [Acylation of sn-glycerol-3-phosphate by subcellular fractions of rat liver]. PMID- 4324246 TI - [Effect of hypophysectomy and of dexamethasone on the activity of adrenal cortex of rats]. PMID- 4324245 TI - [A mutant of foot-and-mouse disease virus thermosensitive to 37 degrees C, characterized as "RNA+"]. PMID- 4324247 TI - Effect of x-irradiation on the functional status of lysosomal enzymes of mouse mammary gland carcinomas. PMID- 4324249 TI - N-acetylation of arginine-rich hepatoma histones. PMID- 4324248 TI - Transfer RNA methylases of normal cells, virus-transformed cells, and tumors derived from transformed cells. PMID- 4324250 TI - Localization of mammary tumor virus inside red blood cells of mice. PMID- 4324251 TI - The susceptibility of Clostridium perfringens type A to cephalosporin C antibiotics in vitro. PMID- 4324252 TI - The effect of freezing on the viability of rat heart muscle as measured by cytochrome oxidase activity. PMID- 4324253 TI - [Clinical experiences with synthetic ACTH (Synacthen)]. PMID- 4324254 TI - Thermal activation of the antiviral activity of synthetic polyribonucleotides: influence of DEAE-dextran in various cell cultures. PMID- 4324255 TI - Structural proteins of herpes simplex virus. PMID- 4324256 TI - C-type virus particles in pig kidney cell lines. PMID- 4324257 TI - Internal components released from rhinovirus and poliovirus by heat. PMID- 4324258 TI - Regulation of homocytotropic antibody formation in the rat. II. Effect of X irradiation. PMID- 4324260 TI - Malignant transformation in vitro by "non-oncogenic" variants of defective SV40 (PARA). PMID- 4324259 TI - Regulation of homocytotropic antibody formation in the rat. 3. Effect of thymectomy and splenectomy. PMID- 4324261 TI - ["Maintenance" in the treatment of periodontal disease--care by patients themselves]. PMID- 4324262 TI - Synthesis and excretion of cyclic adenosine monophosphate in neuroblastoma. PMID- 4324263 TI - Reduced nicotinamide adenine dinucleotide-linked analysis of 2,3 diphosphoglyceric acid: spectrophotometric and fluorometric procedures. PMID- 4324264 TI - A new phenomenon of usefulness in the radioimmunoassay of plasma adrenocorticotropic hormone. PMID- 4324265 TI - Globoid cell leukodystrophy (Krabbe's disease): morphological and biochemical studies. PMID- 4324266 TI - [Studies on taste in lesions of the chorda tympani]. PMID- 4324267 TI - [Remarks on the treatment of chemodectoma of the ear]. PMID- 4324268 TI - [Value of arteriography in the diagnosis of sclerosing angiofibroma]. PMID- 4324269 TI - [Pathogenesis and clinical aspects of infections of the lower respiratory tract. 2]. PMID- 4324270 TI - [Mechanisms that regulate aldosterone biosynthesis during sodium depletion]. PMID- 4324271 TI - [Functional surgery of the middle ear in glomus tumor]. PMID- 4324272 TI - [Maxillofacial neuralgic syndromes. Physiopathology of the peripheral pain of the maxillofacial region]. PMID- 4324273 TI - [Action of thymus lipid extract B on carbohydrate metabolism in mice with implants of Ehrlich's ascitic carcinoma]. PMID- 4324274 TI - [Comparison of eosinopenia caused by acupuncture of the spleen-pancreas meridian with tests of adrenal cortex stimulation (ACTH and insulin)]. PMID- 4324276 TI - [On the nosographic classification of myeloradiculopathies caused by cervical arthrosis]. PMID- 4324275 TI - [The electromyogram during excitation of the spinal accessory nerve]. PMID- 4324278 TI - Juvenile xanthogranuloma associated with cytomegalovirus infection. PMID- 4324279 TI - [Distribution of sulfur in cutaneous epithelioma: microanalysis by X spectrometry]. PMID- 4324277 TI - [Study of the visuo-motor content of dreams in subjects with disorders of ocular motility]. PMID- 4324280 TI - [Preparation of new derivatives of cAMP (substituted in position C-8 and C-2) and study of their action on the release of growth hormone]. PMID- 4324281 TI - [Action of 1-methyl-2-(p-isopropyl-carbamoylbenzyl)-hydrazine chlorhydrate (MIH) on deoxyribonucleic acid]. PMID- 4324282 TI - Glutamate dehydrogenase from pea roots: purification and properties of the enzyme. PMID- 4324283 TI - Increased subcellular hyaluronidase in the rat after hydrocortisone injection. PMID- 4324284 TI - Reversal of the interference by sucrose on protein determination by the biuret method. PMID- 4324285 TI - Deoxyribonucleic acid polymerase from immature testes of salmon. PMID- 4324286 TI - The use of nucleotide-sugar: glycoprotein glycosyltransferases to assess Golgi apparatus function in Morris hepatomas. PMID- 4324287 TI - Reversible inhibition of cytochrome oxidase accumulation in human cells by ethidium bromide. PMID- 4324289 TI - [The evoked potentials and impulse activity of individual neurons of the frog midbrain tectum upon rhythmic stimulation of the optic nerve]. PMID- 4324288 TI - [The cerebellum and reactivity of the adrenal cortex]. PMID- 4324291 TI - [Reactions of the frog olfactory bulb to rhythmic stimulation of the lateral olfactory tract]. PMID- 4324290 TI - [The reactions of frog cerebellar Purkinje cells to stimulation of parallel fibers and afferent nerves]. PMID- 4324292 TI - [Significance of cerebellar nuclei in the origination of autonomic responses induced by electric stimulation of the efferent visceral area of the cat cerebellar cortex]. PMID- 4324293 TI - [Split motor unit potentials of human muscle]. PMID- 4324294 TI - [Impulsation of the central and peripheral segments of the splanchinc and vagus nerves during chemical stimulation of the small intestine mucous membrane]. PMID- 4324295 TI - Bile salt synthesis in transplanted human liver. PMID- 4324296 TI - Adnexal tumors of the skin. PMID- 4324297 TI - Formation of free radicals in aliphatic and aromatic amino acids by trapped electrons: an E.S.R. study. PMID- 4324298 TI - A comparative E.P.R. study on free radical formation in DNA constituents after exposure to discharge-excited argon, hydrogen and deuterium. PMID- 4324299 TI - Cyclic 3'-5'-adenosine monophosphate: its possible role in mammalian cell mitosis and radiation-induced mitotic G2-delay. PMID- 4324300 TI - Mechanisms of recovery from a generalized viral infection: mousepox. II. Passive transfer of recovery mechanisms with immune lymphoid cells. AB - The following passive transfer experiments evaluated the contributions of the various host responses in recovery from mousepox. (a) Immune spleen cells transferred highly efficient antiviral activity, but preinfected recipients of these cells made no detectable splenic interferon or antibody in the 24 hr interval after cell transfer. (b) Passively administered interferon was ineffective. (c) Recipients of hyperimmune serum had much more antibody than recipients of immune spleen cells but significantly less antiviral activity. (d) Immune spleen cell populations with antiviral activity contained mediators of CMI to virus antigens. (e) The antiviral activity of immune spleen cells was specific; it was inhibited by in vitro treatment with ATS, anti-light chain serum, and anti-theta ascitic fluid, but not by removal of mononuclear phagocytes from the immune population. These results are interpreted to mean that recovery mechanisms conferred by immune spleen cells were triggered by specifically sensitized, thymus-derived lymphocytes, and that antibody and interferon responses were of less importance. A radiosensitive recipient component was necessary for the full expression of the antiviral activity of both immune cells and immune serum. It seemed likely that this component was the blood monocyte. PMID- 4324301 TI - Mechanisms of recovery from a generalized viral infection: mousepox. 3. Regression infectious foci. AB - Histological and immunofluorescence techniques showed that mononuclear cells invaded virus-infected foci in the livers of passively immunized mice within 10 hr of the receipt of immune spleen cells or hyperimmune serum; by 24 hr, marked destruction of virus antigens had occurred in these lesions. Immune cell transfer promoted denser packing of mononuclear cells in the foci and more efficient destruction of infectious material than immune serum. Similar liver lesions developed by the 6th day after sublethal, primary, subcutaneous infection in normal mice. In contrast, in mice with GVHR which were immunosuppressed but possessed hyperactive macrophages and unimpaired splenic interferon response, mononuclear cells did not invade liver lesions and the animals died. These results, together with data reported previously, indicated that mononuclear cell invasion of infected liver foci, triggered by CMI, was of key importance in recovery from primary mousepox. The roles of specifically sensitized lymphocytes and macrophages within lesions were not directly evaluated, but indirect evidence suggested that lymphocytes could cause no more than a halt in virus multiplication, and that macrophages were required for the inactivation of preformed virions. Possible augmentation of the efficiency of macrophages by locally-produced lymphocyte interferon, neutralizing antibody, or stimulation of their phagocytic and intracellular digestive capacity cannot be excluded. PMID- 4324302 TI - Infectivity of molecular forms of simian virus 40 DNA. PMID- 4324303 TI - The influence of inhibitors of macromolecular syntheses on capacity of herpes simplex virus to induce chromosomal damage. PMID- 4324304 TI - Studies on lipid metabolism in cells infected with adenovirus. PMID- 4324305 TI - The positional specificity of leptospiral lipases. PMID- 4324306 TI - Application of the fluorescent antibody method in the diagnosis of M. parainfluenzae. 3. Isolation and identification of M. parainfluenzae on monkey kidney tissue cultures and in nasal and nasopharyngeal swabs. PMID- 4324307 TI - The synthesis of higher glycerides via the monoglyceride pathway in hamster adipose tissue. AB - The monoglyceride pathway for the synthesis of triglycerides has been investigated employing subcellular fractions and whole cell preparations of white and brown adipose tissue. Conclusive evidence has been obtained for the monoglyceride pathway in these tissues by employing the 2-monoether analogue of 2 monoolein as the substrate. The monoglyceride and alpha-glycerophosphate pathways were primarily found in the microsomal fraction. In these in vitro systems the activity of the monoglyceride pathway compared with the alpha-glycerophosphate pathway was of the same order of magnitude in whole cell preparations and was approximately one-half the activity of the alpha-glycerophosphate pathway when the microsomal fraction was employed. PMID- 4324308 TI - Composition of human cerebrospinal fluid cerebroside. AB - A technique was developed to isolate sufficient material for compositional analysis of cerebroside from pooled human cerebrospinal fluid. The carbohydrate moiety was principally galactose. The sphingosine base and fatty acid compositions were found to be similar to that of brain cerebroside. The presence of a contaminant in commercial silica gel which chromatographed like the trimethylsilyl derivative of glucose is described. PMID- 4324311 TI - [Intravenous anesthesis. 23. Affinity of tumorous tissue to thiopental]. PMID- 4324309 TI - Reduction in adipocyte ATP by lipolytic agents: relation to intracellular free fatty acid accumulation. AB - Epinephrine, norepinephrine, ACTH, and dibutyryl 3',5'-cyclic AMP reduced adipocyte ATP levels during 60 min incubation; glucose displayed a protective effect. The reduction in adipocyte ATP levels could not be attributed solely to: a direct hormone effect, deficiency in metabolic substrate, activation of adenyl cyclase with ATP consumption, loss of adenine nucleotide from the cell or loss of cells during incubation, lipolytic rate per se, or extracellular accumulation of FFA or glycerol. To determine whether intracellular FFA accumulation was a causative factor, intracellular FFA levels were measured during hormone stimulated lipolysis. This was accomplished by using sucrose-U-(14)C as a marker for the extracellular space to correct for contamination of cells by extracellular albumin-bound FFA. These experiments showed that the fall in adipocyte ATP correlated with FFA saturation of medium albumin and progressive accumulation of FFA within the adipocyte. Furthermore, the protective effect of glucose noted above was associated with a marked reduction in intracellular FFA as compared to the extracellular FFA pool. On the basis of these studies, combined with those in the literature, it is concluded that in vitro effects of lipolytic agents on adipocyte ATP levels are the net result of imparied ATP synthesis (uncoupled oxidative phosphorylation) in the face of normal or augmented ATP consumption. PMID- 4324312 TI - [Abt-Letterer-Siwe-syndrome, vesiculated pneumoreticulosis (type J. Marie) and thymus calcinosis together with cytomegalic inclusions]. PMID- 4324310 TI - Quantitative isolation of total glycosphingolipids from animal cells. AB - The quantitative isolation of total glycosphingolipids from crude lipid extracts without contamination from other lipid classes is described. The method consists of (a) acetylation of total lipids with pyridine and acetic anhydride, (b) separation of acetylated glycolipids from nonglycolipids on a magnesia-silica gel (Florisil) column, and (c) deacetylation of glycolipid in chloroform-methanol sodium methoxide. This method is useful for determination of microgram quantities of glycolipids derived from less than 1 ml of packed cells. PMID- 4324313 TI - "Dream detector" and automatization of REMP-awakening technique for the study of dreaming. PMID- 4324314 TI - A new method for detecting eye movement in sleep. PMID- 4324316 TI - [Fractionation of DNA preparations of tissue in albino rats of different age]. PMID- 4324315 TI - [Studies of the parainfluenzal etiology of diseases of the respiratory tract in children. I. Isolation of a strain of parainfluenza virus of type III]. PMID- 4324317 TI - [Chemodectoma of the concha auriculae]. PMID- 4324318 TI - [Cylindroma of the external ear]. PMID- 4324319 TI - [Human susceptibility to Herpesvirus suis(Aujeszky-virus). 5. Multiplication of the virus in cultivated human cells]. PMID- 4324320 TI - [Studies on the reactivity of cell containing and cell free lymphomatosis-virus material in embryonic eggs. Preliminary report]. PMID- 4324321 TI - Adrenergic nerve elements in the hypogastric ganglion of the guinea pig. PMID- 4324322 TI - The fine structure of perinotochordal microfibrils in control and enzyme-treated chick embryos. PMID- 4324323 TI - Squamous carcinoma of the breast. PMID- 4324324 TI - Disseminated toxoplasmosis and cytomegalovirus infection complicating Hodgkin's disease. PMID- 4324326 TI - [Ophthalmic zona: isolation of a viral strain from the aqueous humor]. PMID- 4324325 TI - Diagnostic significance of abdominal arterial murmurs in liver and pancreatic disease. A phonoarteriographic study. PMID- 4324327 TI - [Neurovascular tumors otherwise called glomus tumor of the finger]. PMID- 4324328 TI - [Normalized metamorphosis achieved by adrenocorticotropic hormone in hypophysectomized and thyroxined Alytes tadpoles]. PMID- 4324329 TI - [Regulation of the synthesis of ribosylamine-5-phosphate by the pyrimidines in Escherichia coli B]. PMID- 4324330 TI - Inorganic pyrophosphatase from Ferrobacillus ferrooxidans (Thiobacillus ferrooxidans). PMID- 4324331 TI - [Transfrontal exposure of the sellar region]. PMID- 4324332 TI - [Virus infections during immunosuppressive therapy following organ transplantation]. PMID- 4324333 TI - The effect of alkylation on substrate- and effector-binding sites in pigeon liver NAD kinase. PMID- 4324334 TI - Nitrogen fixation by extracts of Mycobacterium flavum 301. Use of natural electron donors and oxygen-sensitivity of cell-free preparations. PMID- 4324335 TI - The colonic pericryptal fibroblast sheath: replication, migration, and cytodifferentiation of a mesenchymal cell system in adult tissue. 3. Replication and differentiation in human hyperplastic and adenomatous polyps. PMID- 4324336 TI - Pepsinogens, pepsins, and pepsin inhibitors. PMID- 4324337 TI - Louisiana voodoo and superstitions related to health. PMID- 4324338 TI - Estimation of need, utilization, and costs of personal care homes and home health services. PMID- 4324339 TI - The glucose oxidase mechanism. Interpretation of the pH dependence. PMID- 4324340 TI - Cyclic 3',5'-nucleotide phosphodiesterase. Evidence for and properties of a protein activator. PMID- 4324341 TI - Further characterization of bovine superoxide dismutase and its isolation from bovine heart. PMID- 4324342 TI - Studies on the uptake of hexose phosphates. 3. Mechanism of uptake of glucose 1 phosphate in Escherichia coli. PMID- 4324343 TI - Regulation of gal messenger ribonucleic acid synthesis in Escherichia coli by 3',5'-cyclic adenosine monophosphate. PMID- 4324344 TI - Purification and properties of semisynthetic staphylococcal nuclease-T'. PMID- 4324345 TI - Nuclear membranes and plasma membranes from hen erythrocytes. II. Lipid composition. PMID- 4324346 TI - In vitro regulation of rat heart 5'-nucleotidase by adenine nucleotides and magnesium. PMID- 4324347 TI - Changes in behavior, brain, and neuroendocrine chemistry with age and stress in C57BL-10 male mice. PMID- 4324348 TI - Serum lactate dehydrogenase isoenzymes in health and disease. PMID- 4324349 TI - Meningeal invasion by gliomas. PMID- 4324350 TI - [Clinical trial of an antalgic preparation in rheumatology]. PMID- 4324351 TI - Gas gangrene infections related to compound fractures. PMID- 4324352 TI - Initiation of reovirus mRNA synthesis in vitro. PMID- 4324353 TI - Association of the acetylcholine-phosphatidyl inositol effect with a "receptor" proteolipid from cerebral cortex. PMID- 4324354 TI - Susceptibility of trisomic and of triploid human fibroblasts to simian virus 40 (SV40). PMID- 4324355 TI - [Hypoglycemia and metabolic acidosis with fructose 1-6 diphosphatase deficiency]. PMID- 4324356 TI - Influence of apyrase on stability of suspensions of washed rabbit platelets. PMID- 4324358 TI - Cytochalasin B. I. Effect on cytokinesis of Novikoff hepatoma cells. PMID- 4324357 TI - Antinatriuretic effect of intramuscular cadmium in rats. PMID- 4324359 TI - Vasopressin-evoked ACTH release in rats following forebrain removal. PMID- 4324360 TI - Chloroquine mediated alterations in mammalian cell metabolism and viral replication. PMID- 4324361 TI - Tests for oncogenicity of viruses under conditions of altered host and virus. PMID- 4324362 TI - Multiplication of human enteroviruses in northern quahogs. PMID- 4324363 TI - The cytoplasmatic-nuclear volumetric relationships of the hepatocytes in the livers of patients with hepatocarcinomas, and with primarily extra-hepatic carcinoma. PMID- 4324364 TI - [A new case of thyroid insufficiency after lymphography]. PMID- 4324365 TI - [Modifications of an ascending mandibular ramus and neighboring tumors. 2 cases: a parotid tumor, a neurofibrama of the pterygomaxillary region]. PMID- 4324366 TI - [Hemimelic epiphyseal dysplasia. Study of a case in a 10-month-old infant]. PMID- 4324367 TI - [Septicemia and bacteremia due to enterobacteriaceae of the group Klebsiella Enterobacter-Serratia]. PMID- 4324369 TI - [Mortal medullary aplasia caused by chloramphenicol. Remarks apropos of a case]. PMID- 4324368 TI - [Hypertensions caused by hypermineralocorticism]. PMID- 4324370 TI - [Problems in road safety: alcohol and automobile driving]. PMID- 4324371 TI - [Contribution of neurosurgery to the knowledge of the phenomena of memory]. PMID- 4324372 TI - [Surgery of Parkinson's disease. Justification of a technical evolution]. PMID- 4324373 TI - [Arteriographic visualization of vascular leaks during traumatic juxta-dural hematomas. Pseudo aneurysm of the middle meningeal artery or extravasation of contrast medium]. PMID- 4324374 TI - [Reflexions on psychosurgery in the treatment of obsessional neurosis. Apropos of 20 cases]. PMID- 4324375 TI - [Therapeutic indications and operative results obtained in a series of 80 myelopathies caused by cervicoarthrosis]. PMID- 4324376 TI - [4261 CB (tetrazepam) in the treatment of cerebral palsy. Introduction to the study of the drug and of its action]. PMID- 4324377 TI - The community and the colostomy patient. PMID- 4324378 TI - Questionnaire for domiciliary assessment. PMID- 4324379 TI - Staff development in child management: utilizing the principles of behavior shaping. PMID- 4324381 TI - Analysis of parent guidance groups. PMID- 4324380 TI - The patient, the hospital, and the double-bind. PMID- 4324382 TI - Latent content and covert group forces in therapy with acute psychiatric patients. PMID- 4324383 TI - Progress in community mental health nursing: is role diffusion ending? PMID- 4324384 TI - Staff attitudes toward research. PMID- 4324386 TI - Crisis intervention and nursing practice. PMID- 4324385 TI - TPRs: An old "habit" or a significant routine? PMID- 4324387 TI - Hospital--and after. PMID- 4324388 TI - Excitability and conductivity of human peripheral nerve in hexobarbital sleep. PMID- 4324389 TI - Some metabolic effects of halothane on mammalian tissue culture cells in vitro. PMID- 4324390 TI - Anesthesia and memory processes. PMID- 4324391 TI - Depolarizing neuromuscular block. PMID- 4324392 TI - The enzyme histochemistry of the habenular nuclei of the rat. PMID- 4324393 TI - [Histochemical and biochemical study of the cerebellum of the cat. II. Cytochrome oxidase and succinate dehydrogenase activities]. PMID- 4324394 TI - [On nosological classification of bronchial carcinoid]. PMID- 4324395 TI - [Problems and importance of pyrophosphates in bone metabolism]. PMID- 4324397 TI - [Necrotizing retinitis in severe general diseases]. PMID- 4324396 TI - [Clinical aspects and biochemical diagnosis of hypophosphatasia]. PMID- 4324398 TI - [Enophthalmus, a symptom in orbital tumors]. PMID- 4324399 TI - [Effects of hyperbaric oxygenation on nerve conduction and symaptic transmission in isolated sympathetic ganglion of the rat]. PMID- 4324400 TI - Firing variability in cat association cortex during sleep and wakefulness. PMID- 4324401 TI - Modification of the responses evoked in the cerebellar cortex by limb nerve stimulation during wakefulness and sleep. PMID- 4324402 TI - Lengthening of REM sleep duration consecutive to learning in the rat. PMID- 4324403 TI - Amebiasis in the United States. PMID- 4324405 TI - The serology of amebiasis. PMID- 4324404 TI - Pathogenesis of amebiasis. PMID- 4324406 TI - [Enzymatic determination of cyclic adenosine 3', 5'-monophosphate in the seeds of lettuce, variety "Reine de mai"]. PMID- 4324407 TI - [Isolation and study of a conditional mutant of Rous virus with thermosensitive transforming capacity]. PMID- 4324408 TI - [Effect of 5-bromodeoxyuridine on the expression of the antigen of membrane induced by the polyoma virus on hamster cells]. PMID- 4324409 TI - [Some observations on a virus present in viro-induced tumours of hamsters]. PMID- 4324410 TI - [Role of bradykinin and other mediators in acute inflammation with special reference to acceleration capillary permeability as an indicator]. PMID- 4324411 TI - [Neurosurgical problems and criteria of therapeutic efficiency in acromegaly]. PMID- 4324412 TI - [Contemporary views on the etiopathogenesis of pemphigus]. PMID- 4324413 TI - Long term treatment with ACTH in children with asthma. PMID- 4324414 TI - Side effects of long term steroid therapy in chronic lung disease. PMID- 4324415 TI - [Investigations on disodium cromoglycate (Lomudal)]. PMID- 4324417 TI - [Teaching cancerology]. PMID- 4324418 TI - [Infantile cortical hyperostosis. Apropos of 2 cases, including 1 with metaphyseal lesions]. PMID- 4324416 TI - [Effect of colchicine and allopurinol on uricogenesis. I. Kinetics of their inhibitory action on hepatic xanthine dehydrogenase]. PMID- 4324420 TI - [Alveolar echinococcosis of the liver. New data. II. Radiologic and anatomopathologic study]. PMID- 4324419 TI - [Alveolar echinococcosis of the liver. New data. I. Biological and clinical study]. PMID- 4324421 TI - [Hereditary spherocytosis revealed by an Owren-Gasser syndrome]. PMID- 4324422 TI - [Ileostomy and colostomy. Appliances and counseling]. PMID- 4324423 TI - [Contamination of meat by Clostridium perfringens]. PMID- 4324424 TI - [Changes in creatine kinase activity in the presence of tumor processes in the liver]. PMID- 4324425 TI - [The cytologic picture of thyroid gland cancer]. PMID- 4324426 TI - [Diaphanoscopy and diaphanography in the diagnosis of breast tumors]. PMID- 4324427 TI - [The pathogenesis of experimental hormone producing ovarian tumors]. PMID- 4324428 TI - [Primary carcinoma of the duodenum]. PMID- 4324429 TI - [Pathogenesis of vitamin D-resistant rickets (phosphate diabetes)]. PMID- 4324430 TI - [Patterns in the development of deep cultures of Cl. perfringens]. PMID- 4324431 TI - Hepatoma developing in hemochromatosis in spite of adequate treatment by multiple phlebotomies. PMID- 4324432 TI - Gastrointestinal reactions to drugs. PMID- 4324433 TI - Interuterine diagnosis of cytomegalovirus infection: viral recovery from amniocentesis fluid. PMID- 4324434 TI - [The secretory response of the adrenal gland in obese patients to the injection of beta 1-24 corticotropin]. PMID- 4324435 TI - Chronic polymyositis and myxovirus-like inclusions. Electron microscopic and viral studies. PMID- 4324436 TI - Neuropathy in chronic renal disease. A microscopic, ultrastructural, and biochemical study of sural nerve biopsies. PMID- 4324437 TI - Effect of glucagon, catecholamines and insulin on liver acid lipase and acid phosphatase. PMID- 4324438 TI - Phospholipases in arterial tissue. V. Comparison of the activity of phosphatide acyl-hydrolase and sphingomyelin choline phosphohydrolase in aortae of male, female and ovariectomized rats. PMID- 4324439 TI - Characterization of the phospholipids and the normal and hydroxy acid containing glycosphingolipids (globosides) of pig erythrocytes. PMID- 4324440 TI - Lipids in tissues of the eye. V. Phospholipid metabolism in normal and cataractous lens. PMID- 4324441 TI - [Cytochemical study of leukocytes of mice and rats]. PMID- 4324442 TI - [Pyruvate kinase of rat hepatoma, placenta and fetal liver]. PMID- 4324444 TI - [Therapeutic results of Corticotrophin Spofa infusions in serious discogennic lumboischiatic syndromes]. PMID- 4324443 TI - [Influence of phosphodiesterase of swine spleen on the reconstitution in vitro of tobacco mosaic virus]. PMID- 4324445 TI - [Virological surveys of the presence of enteroviruses in waste water. I. Incidence of polioviruses in Prague at the end of 1968 and in 1969]. PMID- 4324446 TI - [Experimental viral hapatitis in mice in the light of some enzymatic indicators in blood serum or plasma]. PMID- 4324448 TI - The development of innate sleep rhythms in short gestation infants. PMID- 4324447 TI - Clinical biostatistics. 8. An analytic appraisal of the University Group Diabetes Program (UGDP) study. PMID- 4324449 TI - [Changes in lipometabolism in rabbits after application of exogenic angiotensin II]. PMID- 4324450 TI - Information transmission in slowly adapting mechanoreceptor fibers. PMID- 4324451 TI - The functional significance of bile canalicular nucleosidephosphatase activity. Histochemical activity during structural and functional maturation of the developing liver. PMID- 4324452 TI - [Several cases of invading glomic neoplasms of the temporal bone]. PMID- 4324453 TI - [Ultrastructural and clinical study of glomus jugulare tumors (apropos of 3 new cases)]. PMID- 4324454 TI - [Biological clocks. 2. Circadian rhythm of the endocrine system]. PMID- 4324455 TI - [Excitation rhythm in the exciter membrane. I. Introduction to excitation rhythm]. PMID- 4324456 TI - [Excitation rhythm in the exciter membrane. 2. Synaptic transmission]. PMID- 4324457 TI - [Excitation rhythm of the nerve groups. 1. Rhythmic phenomena of the neural circuit]. PMID- 4324458 TI - [Excitation rhythm of the nerve groups. 4. Sleep and wakefulness]. PMID- 4324459 TI - Satellite cells of the frog muscle spindle as revealed by electron microscopy. PMID- 4324460 TI - Merkel cells in sheep epidermis during fetal development. PMID- 4324461 TI - [Ultrastructural study of the hemocytes of the coleopteran Melolontha melolontha (L.)]. PMID- 4324462 TI - A cytochemical investigation into the distribution of cytochrome oxidase activity within the mitochondria of brown adipose tissue from the prenatal rat. PMID- 4324463 TI - [Role of the renin-angiotensin system in the production of thirst]. PMID- 4324464 TI - [Symposium. I. Use of anti-allergic agents and their background]. PMID- 4324465 TI - [Post-traumatic scirrhous adenocancer of the breast]. PMID- 4324466 TI - [The effect of testosterone, methenolone, somatotropic hormone, adrenal cortex hormones and octapeptide hormones on the iron incorporation rate in polycythemic mice]. PMID- 4324467 TI - In vitro thermosensibility of experimental tumors in small animals. PMID- 4324468 TI - [Mechanism of oxygen metabolism]. PMID- 4324469 TI - [Biochemistry of phosphoinositides]. PMID- 4324470 TI - [Study of the morphology and the secretion of an experimental corticotropic tumor in rats]. PMID- 4324471 TI - Cholinergic sensitivity: normal variability as a function of stimulus background. AB - The sensitivity of the normally innervated iris sphincter to its neuro transmitter, acetylchloline, and to relatd agents varies inversely with the preexisting physiological stimulus background, that is, the environmental light intnsity. This normal variability suggests the existence of a negative feedback mechahnism whereby sensitivity of the effector cell is modutlated by a product of neuronal activity. PMID- 4324472 TI - Acetylcholine liberation from cerebral cortex during paradoxical (REM) sleep. AB - The rate of liberation of free acetylcholine from the surface of prostigmin treated cerebral cortex in the freely moving cat has been determined in states of slow wave sleep, paradoxical or activated sleep, and waking. The average rate during slow wave sleep (1.2 nanograms per minute per square centimeter of cortical surface) increased during paradoxical sleep (2.2 nanograms per minute) and during waking (2.1 nanograms per minute). The rate of acetylcholine release is thus related to the electroencephalogram pattern of desynchronized activatin of the cortex rahter than to the behavioral responsiveness of the animals. PMID- 4324473 TI - [Insulinoma with amyloid stroma and satellite adenomatosis with non-B cells]. PMID- 4324474 TI - [Hypoglycemic tumors (radio-immunological study)]. PMID- 4324475 TI - [Hepato-spleno-lymphatic thorotrastosis. Apropos of an anatomo-clinical case]. PMID- 4324476 TI - [Cardio-aortic aspergillosis]. PMID- 4324477 TI - [Cryptoccocosis: an opportunistic disease]. PMID- 4324478 TI - [Febrile, cachectizing and icteric form of Hodgkin's disease or viral infection of undetermined etiology?]. PMID- 4324479 TI - [Gangrene of venous origin. Apropos of 3 unpublished cases, one caused by cryoglobulinemia]. PMID- 4324480 TI - [Biochemistry of surplus synthesis of pyridine adenine dinucleotides]. PMID- 4324481 TI - [Effect of serotonin and calcium on separate components of respiratory chain of mitochondria in some rabbit tissues]. PMID- 4324482 TI - [Contribution of electron microscopy to rapid diagnosis of a vaccinal penile lesion]. PMID- 4324483 TI - [Metabolism of estrogen glucuronates administered by oral route to normal women]. PMID- 4324485 TI - [Phosphoinositides in the nervous system]. PMID- 4324484 TI - [Serotoninergic systems and the problem of false transmitters]. PMID- 4324486 TI - [Adrenal cortex hormones and erythropoiesis]. PMID- 4324487 TI - [Present status of the problem of the structure and chemism of experimental brain neoplasms]. PMID- 4324488 TI - [Effect of experimental open cerebrocranial injury on oxidative processes in brain tissue]. PMID- 4324490 TI - [Vitamin B1 metabolism in laryngeal neoplasms]. PMID- 4324489 TI - [Glucose-6-phosphatase activity and the effect on this activity of some inductors at different stages of liver carcinogenesis]. PMID- 4324491 TI - [Clinico-virological comparisons in children with influenza]. PMID- 4324492 TI - [Malignant chemodectoma of the carotid body]. PMID- 4324493 TI - [Experiences with lymphography]. PMID- 4324494 TI - [Nonchromaffin paragangliomas in children]. PMID- 4324495 TI - [Morphology of the carotid body]. PMID- 4324496 TI - [Pulmonary right-left shunt following oily foot lymphography]. PMID- 4324497 TI - [Anatomo-physiologic and biochemical aspects of pain]. PMID- 4324499 TI - [Tetracosactide in the treatment of asthma]. PMID- 4324498 TI - [Extracerebral gliomas in the facial region]. PMID- 4324500 TI - Plasma levels of ACTH and cortisol in man during halothane anesthesia and surgery. PMID- 4324501 TI - The arthropathy of haemochromatosis. PMID- 4324502 TI - [Specific enzyme activities of the golgi apparatus zone and lysosomes in hepatocytes in culture, in the normal state and after toxic action]. PMID- 4324503 TI - [Study of the mechanism of the effect of glucose on the exagerated biosynthesis of porphyrins due to ethanol intoxication]. PMID- 4324504 TI - The effect of oxaloacetate, ACTH and cortisol on the liver glycogen levels of Tilapia mossambica. PMID- 4324505 TI - [Demonstration of antibodies against avian leukosis using the serum neutralisation test]. PMID- 4324506 TI - Enhancement by morphine of the central descending inhibitory influence on spinal sensory transmission. PMID- 4324507 TI - The nurse practitioner: University Medical Center. PMID- 4324508 TI - Quantitative relationship between stimulus and response in hormone action: amplification and sensitization. PMID- 4324509 TI - [Effect of testosterone, estradiol, progesterone, and their derivatives on the release of ACTH]. PMID- 4324510 TI - The physiology and management of childhood asthma. PMID- 4324511 TI - Labeled bilirubin production by a clonal strain of rat hepatoma cells. PMID- 4324512 TI - The resistance of SV40-transformed 3T3 to supertransformation. PMID- 4324513 TI - Effect of quazodine on phosphodiesterase. PMID- 4324514 TI - Effects of cell fusion on production of the mouse mammary tumor virus- immunofluorescence study. PMID- 4324515 TI - Transfer RNA methylase alterations in polyoma transformed rat embryo culture cells. PMID- 4324516 TI - Viral-induced unresponsiveness of tuberculin-sensitized guinea pig lymphocytes. PMID- 4324517 TI - Evaluation of antihypertensive drugs in dogs with angiotensin-induced hypertension. PMID- 4324518 TI - The vitamin B12-binding proteins of some amphibians. PMID- 4324519 TI - Gluconeogenesis in liver slices from partially hepatectomized rats. PMID- 4324520 TI - [Cylindromas]. PMID- 4324521 TI - [Sleep paralysis: clinical and polygraphic study]. PMID- 4324523 TI - [The kidney and adrenal glands in experimental heart failure]. PMID- 4324522 TI - The relationship of adrenal perfusion to corticosteroid secretion in prolonged hemorrhagic shock. PMID- 4324524 TI - [A simple and specific method for measurement of plasma renin activity in man]. PMID- 4324525 TI - An outbreak of bovine herpes mammilitis in a suckler herd. PMID- 4324526 TI - [Diabetes mellitus. IV. Physiopathology and biochemistry of diabetes mellitus]. PMID- 4324527 TI - [Sciatica and the importance of mechanical etiology in diseases of the peripheral nervous system]. PMID- 4324528 TI - Evaluation of newly synthesised human corticotrophin. PMID- 4324529 TI - Enzymic assays for amoonia and L-glutamine in tissue extracts. PMID- 4324530 TI - A simple method for counting 14C- and 3H-proteins in polyacrylamide gels. PMID- 4324531 TI - Determination of subpicomole levels of NADH and FMN using bacterial luciferase and the liquid scintillation spectrometer. PMID- 4324532 TI - Improved method for hydroxyproline analysis in tissue hydrolyzates. PMID- 4324534 TI - An accurate and convenient organic phosphorus assay. PMID- 4324533 TI - Determination and degradation of microquantities of acetate. PMID- 4324535 TI - Simple method for separation of milligram quantities of protochlorophyll a from seed oils in extracts of whole pumpkin seeds. PMID- 4324536 TI - Peripheral neuropathy and ichthyosis in Krabbe's leucodystrophy. PMID- 4324538 TI - [Inhibitory effect of the polycation oligo-N-methylmorpholiniumpropylene oxide on development demonstrated on the model of metamorphosis of anurics in connection with subcellular distribution of lysosomal acidic phosphatase]. PMID- 4324537 TI - [Histologic aspects of the problem of adrenal cortex hypertrophy]. PMID- 4324540 TI - Phosphodiesterase from human prostate gland. PMID- 4324539 TI - Neuromuscular effects of halothane, suxamethonium and tubocurarine in a myasthenic undergoing thymectomy. PMID- 4324541 TI - [Purification and properties of NAD-dehydrogenases intervening in the germination of Bacillus subtilis spores. I. L. alanine: NAD oxidoreductase (deaminating)]. PMID- 4324542 TI - [Purification and properties of NAD-dehydrogenases intervening in the germination of Bacillus subtilis spores. II. L. leucine: NAD oxidoreductase (deaminating)]. PMID- 4324543 TI - [The karologic behavior of human x mouse cellular hybrids]. PMID- 4324544 TI - Bacteriocins of Clostridium perfringens. 1. Isolation and preliminary studies. PMID- 4324545 TI - Control of serine biosynthesis in Micrococcus lysodeikticus: inhibition of phosphoglyceric acid dehydrogenase. PMID- 4324546 TI - The effect of two herbicies (CIPC and eptam) on oxidative phosphorylation by Nitrobacter agilis. PMID- 4324547 TI - The synthesis of L-serine by Micrococcus lysodeikticus. PMID- 4324548 TI - Stimulation of mammary tumor virus production in a mouse mammary tumor cell line. PMID- 4324549 TI - Carcinogenicity of formic acid 2-[4-(5-nitro-2-furyl)-2-thiazolyl]-hydrazide in Swiss mice. PMID- 4324550 TI - [The adrenal cortex in newborn and other infants]. PMID- 4324551 TI - [Adenohypophysis lesion by means of anti-beta 1-24 corticotropine-I-131 antibodies. Experimental studies and clinical considerations]. PMID- 4324552 TI - [Arteriography of breast carcinomas]. PMID- 4324553 TI - [Indirect, parasternal lymphatic scintigraphy in breast carcinoma. (analysis of 62 cases)]. PMID- 4324554 TI - [Lymphography from the dorsum penis]. PMID- 4324555 TI - [Lymphographic identification of a lymphatic fistula from the retroperitoneal lymphatic system of the pelvis into the free abdominal cavity]. PMID- 4324556 TI - [Chemodectomas of carotid body. Interpretation problems and elective therapeutical solutions]. PMID- 4324557 TI - Krebs EG: Purification and characterization of a protein inhibitor of adenosine 3',5'-monophosphate-dependent protein kinases. PMID- 4324558 TI - Purification and properties of rabbit skeletal muscle adenosine 3',5' monophosphate-dependent protein kinases. PMID- 4324560 TI - Bull semen nicotinamide adenine dinucleotide nucleosidase. I. Purification and properties of the enzyme. PMID- 4324559 TI - Measurement of cyclic 3',5'-denosine monophosphate by the activation of skeletal muscle protein kinase. PMID- 4324561 TI - D(-)-lactate dehydrogenases in fungi. Kinetics and allosteric inhibition by guanosine triphosphate. PMID- 4324562 TI - Effects of lipolytic and antilipolytic agents on cyclic 3',5'-adenosine monophosphate in fat cells. PMID- 4324563 TI - Further evidence for a single leucyl transfer ribonucleic acid synthetase capable of charging five leucine transfer ribonucleic acids in Escherichia coli. PMID- 4324564 TI - Composition of cellular membranes in the pancreas of the guinea pig. I. Isolation of membrane fractions. AB - The subcellular components involved in the synthesis, transport, and discharge of secretory proteins in the guinea pig pancreatic exocrine cell have been isolated from gland homogenates by differential and gradient centrifugation. They include rough and smooth microsomes derived respectively from the rough endoplasmic reticulum and Golgi periphery, a zymogen granule fraction consisting mainly of mature zymogen granules and a smaller population of condensing vacuoles, and a plasmalemmal fraction. Membrane subfractions were obtained from the particulate components by treatment with mild (pH 7.8) alkaline buffers which extract the majority (>95%) of the content of secretory proteins, allowing the membranes to be recovered from the extracting fluid by centrifugation. The purity of the fractions was assessed by electron microscopy and by assaying marker enzymes for cross-contaminants. The rough and smooth microsomes were essentially free of mitochondrial contamination; the smooth microsomes contained <15% rough contaminants. The zymogen granule fraction and its derived membranes were free of rough microsomes and contained <3% contaminant mitochondria. The plasmalemmal fraction was heterogeneous as to origin (deriving from basal, lateral, and apical poles of the cell) and contained varying amounts of adherent fibrillar material arising from the basement membrane and terminal web. The lipid and enzymatic composition of the membrane fractions are described in the following reports. PMID- 4324567 TI - An unusual primary infection with herpes simplex virus: a case report. PMID- 4324565 TI - Composition of cellular membranes in the pancreas of the guinea pig. 3. Enzymatic activities. AB - A COMPARATIVE STUDY OF THE ENZYMIC ACTIVITIES OF MEMBRANE FRACTIONS DERIVED FROM GUINEA PIG PANCREATIC HOMOGENATES HAS YIELDED THE FOLLOWING RESULTS: Rough microsomal membranes (derived from the rough ER) have the reductase activities of the two microsomal electron transport systems but lack enzyme activities of Golgi type (TPPase) and plasmalemmal-type (5'-nucleotidase, beta-leucyl naphthylamidase, Mg-ATPase). Smooth microsomal membranes (derived primarily from the Golgi complex), zymogen granule membranes, and plasmalemmal fractions possess overlapping enzyme activities of plasmalemmal type, in different relative concentrations for each fraction. In addition, the smooth microsomal membranes exhibit TPPase and ADPase activity and share with rough microsomes the reductase activities of the two electron transport chains. Taken together with recent data on the lipid composition of the same fractions (2), these results indicate that the membranes of the pancreatic exocrine cell are chemically and functionally distinct, and hence do not mix with one another during the transport of secretory products. PMID- 4324566 TI - Phospholipid metabolism in intact and modified erythrocyte membranes. AB - Erythrocyte membranes incorporated labeled phosphate from gamma-adenosine triphosphate (AT(32)P) into phosphatidic acid and the polyphosphoinositides. Inositol-(3)H and palmitate-(14)C were also incorporated into the phospholipids but alpha-glycerophosphate-(32)P was not. The incorporation of gamma-AT(32)P into phospholipids was increased when the erythrocyte ghosts were incubated in hypotonic media which lysed the cells. Lysis had little or no effect on the incorporation of inositol-(3)H and palmitate-(14)C into the phospholipids. If erythrocyte membranes were prepared in 1 mM ethylenediaminetetraacetate (EDTA), instead of 1 mM MgCl(2), then the tonicity of the incubating medium did not influence the incorporation of gamma-AT(32)P into the phospholipids. Erythrocyte ghosts, prepared by lysis in water, EDTA, or 1 mM calcium, lead, mercury, zinc, or cadmium, failed to reconstitute when placed in isotonic medium, inasmuch as they did not retain potassium against a chemical gradient. Ghosts prepared by lysis in 1 mM magnesium, barium, or strontium could be reconstituted. Ghosts which failed to reconstitute incorporated more labeled phosphate from gamma AT(32)P into the phospholipids than did intact or reconstituted ghosts. The larger incorporation of labeled phosphate by leaky ghosts was not due to a greater entrance of gamma-AT(32)P into those cells. Primaquine phosphate and digitonin, at concentrations which are known to cause cells to form smaller vesicles or to lyse cells by removing cholesterol, did not increase the incorporation of labeled phosphate into the phospholipids. It is suggested that the increased metabolism of phospholipids may be involved in a membrane repair mechanism. PMID- 4324568 TI - The mechanism of functional vasodilatation in rabbit epigastric adipose tissue. AB - 1. The effect of close-arterial infusions of fat-mobilizing substances has been examined on the release of free fatty acids and blood flow in the epigastric adipose tissue of rabbits.2. All the fat mobilizers in addition to causing the release of free fatty acids also caused an increased blood flow in the fat tissue.3. Both the fat mobilization and the vasodilatation continued for an hour or so after the end of infusion.4. Although no vasodilator substance could be detected in the venous effluent from the activated adipose tissue, a vasodilator could be detected in acid-ether extracts of adipose tissue excised during a period of fat mobilization.5. It is suggested that a vasodilator substance is released or formed in adipose tissue during fat mobilization and that this substance accounts for the vasodilatation accompanying activity in the tissue. PMID- 4324569 TI - Corticosteroid and growth hormone secretion in patients treated with L-dopa. PMID- 4324570 TI - [Clinical and hormonal evaluation of the corticotropic effect of delayed-action beta 1-24 tetracosapeptide]. PMID- 4324572 TI - Retention of antigen specificity of murine sarcoma viruses grown in hamster cells in vitro. PMID- 4324571 TI - [Long term therapy of rheumatoid arthritis in children]. PMID- 4324573 TI - Noradrenaline and "chemical coding" of hypothalamic neurones. PMID- 4324574 TI - Characteristics of the angiotensin I converting enzyme from dog lung. PMID- 4324575 TI - New iew of cross-reactions in anti-angiotensin sera. PMID- 4324576 TI - Ten-year survival in carcinoma of the ovary. PMID- 4324577 TI - [Cell hybridation]. PMID- 4324578 TI - [Hyperparathyroidism and renal lithiasis. Biological diagnosis. Current exploration methods]. PMID- 4324579 TI - Crystal synovitis. PMID- 4324580 TI - [Primary aldosteronism]. PMID- 4324581 TI - [Nature of cytochromes of Trypanosoma cruzi]. PMID- 4324582 TI - [Phagocytosis and pinocytosis of Entamoeba histolytica]. PMID- 4324583 TI - [Wilms' tumor of the renal pelvis in an 18-month-old girl]. PMID- 4324584 TI - [Histochemical enzyme studies on a repeatedly transplanted rat brain tumor]. PMID- 4324585 TI - [Qualitative demonstration of dehydrogenases for determination of the nature of intracranial tumors]. PMID- 4324586 TI - [Morphology and morphological differential diagnosis of carcinoma of the vulva]. PMID- 4324587 TI - The concentration of inorganic pyrophosphate in human saliva and dental calculus. PMID- 4324588 TI - [Possibility of using iminoxylyl radicals to detect unpaired electrons in biological systems]. PMID- 4324589 TI - [Kinetics of photoinduced EPR signal of photosynthesizing bacteria Rhodospirillum rubrum]. PMID- 4324590 TI - Orbital tumours in African children. PMID- 4324591 TI - Central components of the renin-angiotensin system. AB - 1. Re-establishment of renal blood flow after total renal ischaemia of 4 h duration causes a pressor response in pentobarbitone anaesthetized rats and cats.2. The pressor response is related to the release of renin from the ischaemic kidney.3. Spinal section at any cervical level or stellate ganglionectomy abolishes the pressor response but spinal section caudad to the thorax or vagotomy and treatment with hexamethonium have no effect.4. Spinal section and stellate ganglionectomy interfere with the release of renin and with the pressor response to angiotensin. PMID- 4324592 TI - Evidence that angiotensin enhances transmitter release during sympathetic nerve stimulation. AB - 1. The effects of angiotensin on the contractility of the transmurally stimulated rabbit portal vein and coeliac artery have been studied in conjunction with its effects on the release and uptake of (+/-)-(3)H-noradrenaline.2. Angiotensin contracted both vein and artery; these responses were enhanced by veratrine and reduced by tetradotoxin. At low (non-contractile) concentrations of angiotensin, contractions elicited by electrical stimulation (0.5-4 Hz) had a quicker onset and reached a higher maximal tension than control responses. Higher concentrations of angiotensin increased the degree of potentiation. Contractions to noradrenaline were not enhanced by angiotensin.3. Pretreatment of the coeliac artery, portal vein and perfused rat heart with angiotensin did not reduce the subsequent uptake of labelled noradrenaline in the presence of angiotensin. Simultaneous treatment with angiotensin and (3)H-noradrenaline caused a small, apparent inhibition of uptake into the portal vein.4. When the portal vein was incubated with (3)H-noradrenaline there was a marked accumulation of label within the tissue; over 90% of the radioactivity retained in the tissue was identified as intact noradrenaline. When the vein, or artery, was superfused with amine-free Krebs there was a steady basal release of label; the greater proportion of this label was identified as deaminated metabolites. Electrcal stimulation evoked a frequency dependent release of (3)H above basal levels. The greater proportion of this increased efflux was due to the release of intact (3)H-noradrenaline, with smaller increases in the amount of O-methylated and deaminated metabolites.5. Angiotensin increased the efflux of labelled noradrenaline + normetanephrine, or of total (3)H, during transmural stimulation (0.5-4 Hz) in both the vein and artery, but did not increase the efflux of deaminated products during electrical stimulation. The output of labelled noradrenaline + normetanephrine was usually doubled in the presence of angiotensin (200-500 ng/ml) during electrical stimulation of the portal vein.6. Cocaine (4 mug/ml) potentiated responses to noradrenaline and transmural stimulation, and doubled the output of (3)H or labelled noradrenaline + nor-metanephrine during electrical stimulation. Cocaine did not alter the potentiating effects of angiotensin.7. Angiotensin elicited transitory increases in the basal efflux of (3)H from both the portal vein and coeliac artery. However, this did not account for the marked increase in efflux seen during electrical stimulation. Vasopressin did not potentiate responses to transmural stimulation or significantly influence the efflux of (3)H from the vein or artery.8. Noradrenaline and 5-hydroxytryptamine, but not acetylcholine, markedly increased the efflux of (3)H from the portal vein. This increase in efflux of label is believed to result from an exchange of exogenous noradrenaline and 5-hydroxytryptamine with labelled tissue stores of noradrenaline.9. It is suggested that angiotensin is able to facilitate the release of the sympathetic transmitter and that this is the basis for its action in potentiating the responses to sympathetic stimulation. It is also suggested that the nor adrenaline releasing action of angiotensin (by excitation of sympathetic nerve endings) has led to confusion in previous investigations of the effects of angiotensin on noradrenaline uptake. PMID- 4324593 TI - In pursuit of the alpha-adrenoceptor: a fine-structural and electron autoradiographic study using 3H-phenoxybenzamine and smooth muscle from the cat and guinea-pig. AB - 1. Electron microscopical evaluation of sets of serial fine sections of pancreatic arteriolar muscle of the cat showed no significant difference between the number of pinocytotic vesicles per unit length of smooth muscle cell membrane in ;synaptic' and ;non-synaptic' regions.2. With high resolution autoradiography, (3)H-phenoxybenzamine was found to be distributed over the cytoplasm and nuclei of smooth muscle cell profiles of guinea-pig vas deferens, although no localization in relation to discrete morphological organelles was evident.3. ;Specific protection' of alpha-adrenoceptors using 606 muM noradrenaline resulted in a significant diminution in the binding of (3)H-phenoxybenzamine as evidenced by a decrease in silver grain concentrations over smooth muscle cell profiles in autoradiographs.4. The significance of these findings in relation to the site and distribution of alpha-adrenoceptors is discussed. PMID- 4324594 TI - Effects of adrenaline on nerve terminals in the superior cervical ganglion of the rabbit. AB - 1. Adrenaline decreases the release of transmitter from the presynaptic nerves in the superior cervical ganglion of the rabbit. The presynaptic mechanism of adrenaline action was investigated with micro-electrode techniques.2. Adrenaline (10(-5)M) did not change the threshold of the presynaptic nerve terminals to a current stimulus.3. The effect of adrenaline on the excitatory postsynaptic potential (e.p.s.p.) was decreased when the calcium concentration of the perfusing solution was increased to 10 mM.4. The effect of adrenaline on a train of e.p.s.ps (30-50 Hz) was analysed. Adrenaline decreased the readily available stores of transmitter, but only slightly changed the probability of release.5. The probability of release was increased when the calcium concentration was increased to 5 mM.6. It was concluded that adrenaline acts directly on excitation release coupling in the presynaptic terminals. PMID- 4324595 TI - Effect of (plus or minus) dihydroxy ephedrine and (plus or minus) dihydroxy pseudoephedrine on adrenergic transmission in mesenteric arteries. AB - 1. The effect of (+/-) dihydroxy ephedrine (DHE), (+/-) dihydroxy pseudoephedrine (DHPE) and isoprenaline on the vasoconstrictor responses of the perfused mesenteric arteries of the rat produced by stimulation of their periarterial sympathetic fibres, and in the responses to injected noradrenaline, has been studied.2. DHE and DHPE inhibited the responses to nerve stimulation and increased the responses to injected noradrenaline.3. Isoprenaline slightly decreased the basal perfusion pressure and reduced the responses to both nerve stimulation and injected noradrenaline. Since these effects of isoprenaline were abolished by propranolol, they are presumably mediated by beta-receptors.4. The inhibitory effect of DHE and DHPE on the responses to nerve stimulation was not abolished by propranolol.5. The results suggest that DHE and DHPE impair adrenergic transmission by partially replacing the adrenergic neurotransmitter, thereby acting as a false neurotransmitter. PMID- 4324596 TI - Alterations in sleep-wakefulness cycle in rats following treatment with (+) lysergic acid diethylamide (LSD-25). PMID- 4324598 TI - Thyroid lymphography. PMID- 4324597 TI - A possible role for nucleoside-protein complexes in membrane. PMID- 4324599 TI - Impairment of gastric mucus by cortisol and adrenocorticotrophic hormone (ACTH). PMID- 4324600 TI - Breast carcinoma tissue culture. A reliable method and study of hormonal effects. PMID- 4324601 TI - Healing of colonic anastomoses in the rat following irrigation with mercury perchloride and cetrimide solution. PMID- 4324602 TI - Some characteristics of viruses isolated from bull semen and their possible pathogenicity. PMID- 4324603 TI - [Culture of the aphthous fever virus on surviving bovine lingual epithelium. New technic allowing an increased viral yield: multiculture technic]. PMID- 4324604 TI - Antibodies to mannophosphoinositides in leprosy patients. PMID- 4324605 TI - Cyclic AMP and calcium exchange in a cellular slime mold. PMID- 4324606 TI - Nucleotide pools of Novikoff rat hepatoma cells growing in suspension culture. I. Kinetics of incorporation of nucleosides into nucleotide pools and pool sizes during growth cycle. PMID- 4324607 TI - Nucleotide pools of Novikoff rat hepatoma cells growing in suspension culture. II. Independent nucleotide pools for nucleic acid synthesis. PMID- 4324608 TI - Mammary tumors in strains BL-LyDe and SWR-LyDe mice. PMID- 4324609 TI - Minute virus of mice. II. Prevalence, epidemiology, and occurrence as a contaminant of transplanted tumors. PMID- 4324610 TI - Plaque types and cell-free virus from tissue cultures infected with Cal-1 strain of herpesvirus associated with Marek's disease. PMID- 4324611 TI - Viral antigen, virus particles, and infectivity of tissues from chickens with Marek's disease. PMID- 4324612 TI - Effects of various oncogenic agents on tumor-producing capabilities of series D BALB-c mammary nodule outgrowth lines. PMID- 4324613 TI - Lack of effect of bursectomy on Marek's disease. PMID- 4324614 TI - Specificity of spectrophotometric determination of ephedrine and other phenalkanolamine drugs as benzaldehydes after periodate oxidation. PMID- 4324615 TI - Effects of renal transplantation on uremic neuropathy. A clinical and electrophysiologic study. PMID- 4324616 TI - Recovery from uremic neuropathy. PMID- 4324617 TI - [Noise and vibration]. PMID- 4324618 TI - The effect of an interferon inducer on Eimeria maxima in the chicken. PMID- 4324619 TI - [Ultrastructure of a polymorphic pituitary adenoma]. PMID- 4324620 TI - [Osteolathyrism, an osteoneural growth disorder]. PMID- 4324621 TI - Canine adenovirus pneumonia. PMID- 4324622 TI - The pathology of experimental infection of pigs with type I reovirus of porcine origin. PMID- 4324623 TI - Experimental infection of pigs with a human strain of type I reovirus. PMID- 4324624 TI - The typing of bluetongue virus. PMID- 4324625 TI - [Radiographic magnification in cerebral arteriography]. PMID- 4324626 TI - Impulse transmission to muscle fibres during intravenous regional anaesthesia in man. PMID- 4324627 TI - The validity of gravimetric measurements of respirable coal mine dust. PMID- 4324628 TI - Reductions of dust exposures in the slate industry. PMID- 4324629 TI - Poisoning due to organophosphate insecticides. Acute and chronic manifestations. PMID- 4324630 TI - Adult respiratory distress syndrome. PMID- 4324631 TI - [Thecoma of the ovary (anatomo-clinical contribution)]. PMID- 4324632 TI - Identification and properties of complex forms of SV40 DNA isolated from SV40 infected African Green monkey (BSC-1) cells. PMID- 4324633 TI - Oligodeoxyribonucleotides from pulse-labeled mammalian cells. PMID- 4324634 TI - Kinetic studiesof ribonuclease St-catalysed hydrolysis of guanosine and inosine 2',3'-cyclic phosphates, and comparison with ribonuclease T 1. PMID- 4324635 TI - Phenylalanine tRNA synthetase from Drosophila melanogaster. I. L-phenylalanine activation optima for pH, temperature and Mg2+ estimation of molecular weight. PMID- 4324637 TI - Cutaneous reactions to imipramine and chlordiazepoxide. PMID- 4324638 TI - [Hypoglycemizing extrapancreatic tumors: case of retroperitoneal non-chromaffin paraganglioma]. PMID- 4324636 TI - Acute metabolic response in myocardial infarction. AB - Acute myocardial infarction is viewed as a severe trauma causing a generalized metabolic reaction; an acute emotional stress with further metabolic implications; and a localized wound in which there is an acute increase in carbohydrate metabolism, followed by protein synthetic reactions leading to scar formation. The metabolic response is vital to the patient's successful adaptation to his myocardial infarction. PMID- 4324639 TI - [Influence of mycoplasma infections in permanent cell cultures on the propagation of enteroviruses and the elimination of mycoplasma infections using antibiotic therapy]. PMID- 4324640 TI - Studies on rat-liver phosphatases. II. Effect of acetoacetate and reversal by insulin in vivo. PMID- 4324641 TI - The Lennox syndrome. A clinical study of 40 children. PMID- 4324642 TI - Cross-sectional and longitudinal studies of ageing. Ageing in bone as a model. PMID- 4324643 TI - The ultrastructure of the aged rat zona fasciculata under various stressing procedures. PMID- 4324644 TI - [Experimental dimethylformamide poisoning. VII. Liver lysosomes changes in the course of DMFA poisoning]. PMID- 4324645 TI - Methods for coupling protein or polysaccharide to red cells by periodate oxidation. PMID- 4324646 TI - Penicillin and polymyxin effects on the chromogenesis of Pseudomonas aeruginosa strains. PMID- 4324647 TI - The template activities of nuclear RNAs from rat liver, regenerating liver and hepatoma AH-130 cells. PMID- 4324648 TI - Studies on temperature sensitivity on adrenaline-induced lipolysis in rat adipose tissue. PMID- 4324649 TI - Occurrence of cobalt coproporphyrin in Propionibacterium arabinosum. PMID- 4324650 TI - Effect of salts on the N-F transition of bovine plasma albumin. PMID- 4324651 TI - A simple chemically defined medium for the production of phase I Bordetella pertussis. PMID- 4324652 TI - Long-term remission following castration for advanced breast cancer. PMID- 4324653 TI - Encephalitis with acute Parkinsonian syndrome and bilateral inflammatory necrosis of the substantia nigra. PMID- 4324654 TI - The pattern of neurological illness in tropical Africa. Experience at Ibadan, Nigeria. PMID- 4324655 TI - Diagnosis and treatment of herpes encephalitis. A multidisciplinary approach. PMID- 4324656 TI - Differentiation of fibre types in normal and dystrophic hamster muscle. PMID- 4324657 TI - [A method for the measurement of plasma renin activity. II]. PMID- 4324658 TI - [Surgical treatment of soft tissue tumors]. PMID- 4324659 TI - [Rapid identification of hepatitis virus using counter-current immunoelectrophoresis]. PMID- 4324660 TI - [Radiological aspects and clinical considerations on primary tumors of the trachea. (Personal cases)]. PMID- 4324662 TI - Bilirubin toxicity in hepatoma cells. PMID- 4324661 TI - Effect of noradrenaline and prostaglandin E1 on adenosine 3',5'-monophosphate formation in isolated pericardial fat cells of man. PMID- 4324663 TI - [Intestinal passage of iodized oily contrast media and their demonstration in the thoracic duct of the cat]. PMID- 4324664 TI - [Translinear hepatography with lipiodol ultra fluid]. PMID- 4324665 TI - Tumor immunity: tumor suppression in vivo initiated by soluble products of specifically stimulated lymphocytes. AB - Supernatant fluids of specifically stimulated lymphocyte cultures were purified. Fractions containing migration inhibition factor when injected intra-dermally into strain-2 guinea pigs produced a reaction similar in appearance to delayed cutaneous hypersensitivity. There was an accumulation of mononuclear cells at the injection sites and the growth of syngeneic tumor grafts at the sites was suppressed. PMID- 4324666 TI - Vitamin D3: induction of calcium-binding protein in embryonic chick intestine in vitro. AB - Induction of the synthesis of calcium-binding protein in chick embryonic intestine maintained in vitro was accomplished by simply adding vitamin D(3) to the culture medium. Accompanying the induction of this protein, there was enhanced radiocalcium uptake by the intestine. These observations represent the first demonstration of an in vitro physiological effect of vitamin D(3) on the calcium absorptive mechanism of the intestine. PMID- 4324667 TI - Destruction of mammalian motor nerve terminals by black widow spider venom. AB - Black widow spider venom selectively poisons motor nerve endings. A progressive and irreversible failure of neuromuscular transmission occurs in the cat. Electron microscopy of the poisoned nerve-muscle junction shows a sequence of motor nerve ending damage that culminates in disruption of the prejunctional membrane and loss of all organelles, including synaptic vesicles. The postjunctional membrane was morphologically unaffected. After complete poisoning, the contractile response to exogenous acetylcholine was severely impaired, an indication that the prejunctional site is chiefly involved in the contractile response produced by exogenous acetylcholine and that the pre- and postjunctional effects of acetylcholine were separated. PMID- 4324668 TI - Adenosine 3',5'-monophosphate-dependent protein kinase of cultured mammalian cells. AB - Protein kinase was partially purified from Chang's liver cells, 3T6 mouse embryo fibroblasts, and HeLa cells. The rate of histone phosphorylation catalyzed by the kinase from each of these cell lines was stimulated two- to three-fold by 1 x 10( 6) molar adenosine 3',5'-monophosphate. The same concentration of guanosine 3',5' monophosphate failed to stimulate these kinases. PMID- 4324669 TI - RNA synthesis in polyoma virus-infected mouse embryo cells in tissue culture. PMID- 4324671 TI - [Application of the thermoreflection technic in the analysis of band structure of a solid state]. PMID- 4324670 TI - Experimental immunization of cattle against bovine keratoconjunctivitis. PMID- 4324672 TI - The effects of calcium and magnesium of PTH secretion. PMID- 4324673 TI - [Mucous carcinoma of the prostate gland]. PMID- 4324674 TI - [ACTH secretion disorders and their sequellae]. PMID- 4324675 TI - [Adrenal glycoactive function in the course of myocardial infarct. 3. Dynamic ACTH, methopirone and 6-methyl-prednisolone loading tests]. PMID- 4324677 TI - Role of glucagon and adrenergic receptors in thyrocalcitonin release in the dog. PMID- 4324676 TI - Early localization of 125-I-labelled human growth hormone in adrenals and other organs of immature hypophysectomized rats. PMID- 4324678 TI - Glycogen metabolism of the thyroid. PMID- 4324679 TI - Inhibitory effect of L-dihydroxyphenylalanine on the venous 17 hydroxycorticosteroid response to surgical stress in dogs. PMID- 4324680 TI - Studies in 80 per cent pancreatectomized rats of the synergistic interaction of growth hormone, ACTH and the glucocorticoids (corticosterone, cortisol, prednisone and dexamethasone) as diabetogenic agents. PMID- 4324681 TI - Studies on a neuraminidase containing gonadotropin inhibitor substance in bovine pituitary extracts. PMID- 4324682 TI - Lack of hypertrophy of the adrenal in exencephalic fetal rats subjected to hypervitaminosis A and then to maternal adrenalectomy. PMID- 4324683 TI - [Combined clinical and mammographic mass screening in breast cancer]. PMID- 4324684 TI - Filter paper blood samples used in serological studies of respiratory virus infections in children. AB - Filter paper blood samples were used to measure complement-fixation antibody in 34 children with sore throats. The method was satisfactory and should be particularly useful to minimize trauma in general practice and to conserve reagents in developing countries. PMID- 4324685 TI - Bronchiolitis obliterans, bronchiectasis, and other sequelae of adenovirus type 21 infection in young children. AB - A remarkably high incidence of bronchiectasis and other pulmonary sequelae was observed in young children affected during an epidemic of severe lower respiratory tract infections apparently caused by adenovirus type 21. The histopathological findings are described in four cases in which one or both lungs were obtained for examination at intervals ranging from two months to three years after the acute infections. Widespread bronchiolar obliteration (bronchiolitis obliterans) was a striking finding in all four. The severity of bronchial inflammation and of bronchiectasis was proportional to the time elapsed since the acute infections. Bronchiolar obliteration is a likely sequel of the necrotizing bronchiolitis which may occur during acute adenovirus infections. The role of bronchiolar obliteration in the pathogenesis of bronchiectasis and other chronic lung disease is discussed. Adenoviruses may be a major cause of post-infectious bronchiectasis in childhood. PMID- 4324686 TI - Isolation and characterization of kinetoplast DNA from Leishmania tarentolae. PMID- 4324688 TI - [Influence of lymphography on dissemination of cancer cells in rabbits (preliminary study)]. PMID- 4324687 TI - Studies on the role of 23 s nucleolar RNA as an intermediate in the synthesis of 18 s ribosomal RNA. PMID- 4324689 TI - The occurrence of Bordetella pertussis serotypes in Australia, 1950-1970. PMID- 4324690 TI - [Special ultrastructure of human gliomas]. PMID- 4324691 TI - [The effect of an adrenocortical inhibitor on urinary 17-ketogenic levels and on water-salt exchange. (Metopirone test. Experimental studies)]. PMID- 4324692 TI - A case of mixed tumour of the parotid gland. PMID- 4324693 TI - [Sebaceous-like cells in salivary glands and in salivary gland tumors]. PMID- 4324694 TI - [Cytological evaluation of fluids from body cavities. 3. Malignant lymphoma cells]. PMID- 4324695 TI - [Cylindroma of the vulva]. PMID- 4324697 TI - [2 cases of arrhenoblastoma of the ovary]. PMID- 4324696 TI - [Morphological and histoformative characteristics of sarcoma synoviale]. PMID- 4324698 TI - [Histoenzymatic findings on the thyroid of normal rats or rats treated with thiouracil]. PMID- 4324699 TI - [Paraneoplastic dermatosis in endocrine type carcinoma of the pancreas]. PMID- 4324700 TI - Serologic properties of lipopolysaccharide endotoxins from oral fusobacteria. PMID- 4324701 TI - [Remote results of removal of mixed salivary gland neoplasms]. PMID- 4324702 TI - [Diagnosis and treatment of malignant synovioma]. PMID- 4324703 TI - Long-term trophic effect of ACTH on rat adrenocortical cells. An ultrastructural, morphometric and autoradiographic study. PMID- 4324704 TI - [On the existence of cells of the "corticotrophic" type in the intermediate lobe of the rat hypophysis. An electronmicroscopic study]. PMID- 4324705 TI - [Gas gangrene after common bile duct exploration]. PMID- 4324706 TI - Entameba gingivalis in sputum. Its distinction from Entameba histolytica. PMID- 4324707 TI - Effect of synthetic ACTH on adrenocortical function in man and in the rat. PMID- 4324709 TI - [A case of sarcoidosis with involvement of nervous system]. PMID- 4324708 TI - [Effects of 5'-AMP and FAD on the oxygen consumption of the isolated rabbit cornea]. PMID- 4324710 TI - [Polymicroadenomatosis of the adrenal cortex in Cushing's syndrome. 15 cases]. PMID- 4324712 TI - [Enzymes and lipids in resected lungs of patients with tuberculosis and diabetes mellitus (histochemical study)]. PMID- 4324713 TI - [Cylindroma of the salivary glands (histocytologic study)]. PMID- 4324715 TI - The nature of complex formation between cytochrome c and cytochrome c peroxidase. PMID- 4324714 TI - Vibrio cholerae enterotoxin and its mode of action. PMID- 4324716 TI - [Catabolic repression, 1970]. PMID- 4324717 TI - Mitochondrial DNA from cells transformed by Avian myeloblastosis virus. PMID- 4324718 TI - [Treatment of some inflammatory disorders of the ear with an association of fluocinolone acetonide, polymyxin B and neomycin]. PMID- 4324719 TI - Carcinoma in situ associated with virus-containing anal warts. PMID- 4324720 TI - [Evolution and duration of anti-aphthous immunity in the primo-vaccinated ox]. PMID- 4324721 TI - Persistence of foot-and-mouth disease virus in animals, their products and the environment. PMID- 4324722 TI - The phosphorus components of solubilized erythrocyte membrane protein. PMID- 4324723 TI - [Interaction of dendrite potentials]. PMID- 4324724 TI - [Role of the reticuloendothelial system in the development of some experimental virus infections]. PMID- 4324725 TI - [Actinomycin D binding with the DNA of some transplantable tumors]. PMID- 4324726 TI - [Estimation of redundancy of the cytochrome oxidase activity regulation system in the neuron in different functional states]. PMID- 4324727 TI - [Effect of systemic virus infection on the free radical state of plant-host leaves]. PMID- 4324728 TI - [Cortical control of excitation transmission in the rabbit lateral geniculate body]. PMID- 4324729 TI - [Mechanism of disorders of the function of the neuromuscular apparatus under the effect of vibration]. PMID- 4324730 TI - Some factors affecting the survival of airborne viruses. PMID- 4324731 TI - Dissociation of antibody from erythrocyte surfaces by chaotropic ions. PMID- 4324732 TI - Biophysical characterization of the yaba tumor pox virus. PMID- 4324733 TI - [Plasma 17-OHCS and 17-KS (including the urine content--how to read its figures]. PMID- 4324734 TI - [ACTH--how to read its figures]. PMID- 4324736 TI - [Side effects of drugs. 2. Gastrointestinal side effects]. PMID- 4324735 TI - A study on the interaction between tumors and hosts from histochemical view point of carbohydrate metabolism. PMID- 4324737 TI - [Side effects of drugs. 4. Drug induced polyneuropathies and myopathies]. PMID- 4324738 TI - [Simple method of determination of 17-hydroxycorticosteriods in the urine in the diagnosis of adrenal diseases]. PMID- 4324739 TI - Malignant insulinoma treated with streptozotocin. PMID- 4324740 TI - Herpesvirus saimiri: in vitro sensitivity to virus-induced interferon and to polyriboinosinic acid: polyribocytidylic acid. PMID- 4324741 TI - Emergence of a tonic-phasic model for sleep and dreaming: behavioral and physiological observations. PMID- 4324742 TI - [A case of virilizing tumor of the adrenal cortex in a 3-year-old Congolese child]. PMID- 4324743 TI - [Virology and epidemiology of poliomyelitis in Spain during the years 1964-68]. PMID- 4324744 TI - Laboratory investigation of the human hypothalamic-pituitary-adrenocortical system. PMID- 4324745 TI - [Dependence of sialic acid content in tissues on the functional state of the pituitary-adrenal system]. PMID- 4324746 TI - [Properties of muscular aldolase in rabbits undrr fasting condition]. PMID- 4324747 TI - [Virus-induced myelogenous leukemias of the mouse. Electron microscopic and morphometrical studies]. PMID- 4324748 TI - [Precocious puberty]. PMID- 4324749 TI - [2 cases of glandular bronchial tumors diagnosed during brocchoscopy]. PMID- 4324750 TI - [Ultrastructural study of the interrenal cells of Salamandra salamandra L. (Amphibiam Urodeles). II. Effect of endogenous ACTH]. PMID- 4324751 TI - [Clinical aspects of malignant synovialomas]. PMID- 4324752 TI - [Kaposi-Juliusberg pustulosis due to herpetic primo-infection in an adult with constitutional eczema]. PMID- 4324753 TI - [2 cases of Abrikosov's tumor with cutaneous localization]. PMID- 4324754 TI - [The intraviral nature of photoinactivation of proflavin-sensitized foot-and mouth disease virus]. PMID- 4324755 TI - Susceptibility to some animal viruses of cells transformed by SV40 or polyoma virus. PMID- 4324756 TI - [Proteolytic properties of Clostridium perfringens]. PMID- 4324758 TI - [Solitary bone metastases simulating inflammatory processes or primary tumors of the skeleton]. PMID- 4324757 TI - [Compression of posterior tibial nerve in the retromalleolar canal caused by tendon ganglion]. PMID- 4324759 TI - NAD plus-pyridoxine and NAD plus-pyridoxamine complexes. PMID- 4324760 TI - The interaction of norepinephrine and prostaglandin E1 on the adenyl cyclase system of human and rabbit blood platelets. PMID- 4324761 TI - Thyroid hydrolysis of cyclic AMP as influenced by thyroid gland activity. PMID- 4324762 TI - Hypophyseal regulation of hepatic histidase during postnatal development and adulthood. I. Pituitary suppression of histidase activity. PMID- 4324763 TI - Hypophyseal regulation of hepatic histidase during postnatal development and adulthood. II. Pituitary-estrogen interrelationship. PMID- 4324765 TI - [Effects of a derivative of the thiazolic fraction of vitamine B1 on neuromuscular transmission]. PMID- 4324764 TI - Studies on the biosynthesis of factor VII (proconvertin). The mode of action of warfarin. PMID- 4324766 TI - [Induction of anti-ACTH antibodies with polymers]. PMID- 4324767 TI - [Quantitative determination of acid phosphatases in a tissue extract]. PMID- 4324768 TI - The effect of actinomycin D on the in vitro adrenal secretory rhythm of the hamster. PMID- 4324769 TI - [Lipiodol hepatography and lymphaticovenous fistula]. PMID- 4324770 TI - Structure and ultrastructure of the labial salivary glands in patients with cystic fibrosis. AB - The morphology of the labial salivary glands in subjects with and without cystic fibrosis has been studied by light and electron microscopy. The terms ;light' cell, ;dark' cell, ;clear' cell, and ;myoepithelial' cell are used to describe the four cell types distinguished at the level of the electron microscope. The dark cells were found to stain specifically with alcian blue at and above pH 1.0, and the light cells to stain specifically using the periodic acid-Schiff (PAS) technique. This staining reaction suggests that an acidic mucosubstance is being produced by the dark cells and a neutral mucosubstance by the light cells. While no marked morphological differences were observed in the labial glands of patients with cystic fibrosis when contrasted with normal controls, it was observed that the cells from patients with cystic fibrosis contained quantitatively more mucus. PMID- 4324771 TI - Antibiotics in mycoplasma media and the temporary storage of specimens containing mycoplasmas of the genital tract. PMID- 4324772 TI - The hypoglycemias of childhood and their evaluation. PMID- 4324773 TI - Receptor activity for porcine enteroviruses in pig tissues. PMID- 4324774 TI - The effect of different environmental conditions on some characters of Haemophilus paraphrophilus. PMID- 4324775 TI - [Is anterior resection of the rectum for cancer radical?]. PMID- 4324776 TI - [Resistance of viruses in eye drops]. PMID- 4324777 TI - [Order and orientation of elements in the visual system of the fly]. PMID- 4324779 TI - [In vitro antirenin effect of renal phospholipids]. PMID- 4324780 TI - [Glomus tumors]. PMID- 4324778 TI - Hypogammaglobulinaemia in the United Kingdom. VII. The role of humoral antibodies in protection against and recovery from bacterial and virus infections in hypogammaglobulinaemia. PMID- 4324781 TI - [To sleep--perhaps also to dream]. PMID- 4324782 TI - [Current problems of infectious diseases in children]. PMID- 4324783 TI - Reverse transcription: one year later. PMID- 4324784 TI - Is aflatoxin carcinogenic in man? The evidence in Swaziland. PMID- 4324785 TI - Viral antibodies in the Korekore Tribe of Northern Rhodesia. PMID- 4324786 TI - Surgical management of facial paralysis in Bell's Palsy, chronic otitis media and trauma. PMID- 4324787 TI - [Vascular diseases of the vulva (2.) 1. Glomangiom (Glomustumor). 2. Kasebach Merritt syndrome. 3. Mafucci-syndrome (Mafucci-Kast-syndrome)]. PMID- 4324788 TI - A specific common chromosomal pathway for the origin of human malignancy. II. Evaluation of long-term human hazards of potential environmental carcinogens. PMID- 4324789 TI - The solid-state physics of electron and ion transport in biology. PMID- 4324791 TI - [Results of treatment by segmental colectomy of cancers of the left colon. Apropos of a series of 100 cases]. PMID- 4324790 TI - Clostridium welchii septicotoxemia. A review and report of 3 cases. PMID- 4324792 TI - Cystosarcoma phyllodes. PMID- 4324793 TI - Angiographic diagnosis and localization of endocrine tumors. PMID- 4324794 TI - Effect of sleep on the early components of the averaged electroencephalic response. PMID- 4324795 TI - Molar ratio of simple sugars in bacterial fractions of Cl. perfringens type A. PMID- 4324796 TI - [Direct inhibition, by cortisol, of ACTH release by the fetal pituitary gland of rats submitted to hypothalamic extract]. PMID- 4324797 TI - [Ultrastructural study of brown fat in the atrichous Wistar AG rat]. PMID- 4324798 TI - An improved method for determination of serum and plasma triglycerides. PMID- 4324799 TI - Conjugation of phenolic steroid ring D alpha-ketols in human pregnancy urine. PMID- 4324800 TI - Carboxycathepsin--a key regulatory component of two physiological systems involved in regulation of blood pressure. PMID- 4324801 TI - Lung tumors of primates and rodents. PMID- 4324802 TI - Preferential transcription of Bacillus subtilis light deoxyribonucleic acid strands during sporulation. AB - Messenger ribonucleic acid (RNA) from log and sporulation stages of growth were transcribed mainly from the heavy strand of the complementary strands of Bacillus subtilis deoxyribonucleic acid (DNA). During sporulation a slight transcription shift from heavy to light DNA strands was observed. RNA-DNA hybrid competition experiments revealed that this shift was due to sporulation-specific transcription from light-DNA strands. PMID- 4324803 TI - Separate nitrite, nitric oxide, and nitrous oxide reducing fractions from Pseudomonas perfectomarinus. AB - Pseudomonas perfectomarinus was found to grow anaerobically at the expense of nitrate, nitrite, or nitrous oxide but not chlorate or nitric oxide. In several repetitive experiments, anaerobic incubation in culture media containing nitrate revealed that an average of 82% of the cells in aerobically grown populations were converted to the capacity for respiration of nitrate. Although they did not form colonies under these conditions, the bacteria synthesized the denitrifying enzymes within 3 hr in the absence of oxygen or another acceptable inorganic oxidant. This was demonstrated by the ability, after anaerobic incubation, of cells and of extracts to reduce nitrite, nitric oxide, and nitrous oxide to nitrogen. From crude extracts of cells grown on nitrate, nitrite, or nitrous oxide, separate complex fractions were obtained that utilized reduced nicotinamide adenine dinucleotide as the source of electrons for the reduction of (i) nitrite to nitric oxide, (ii) nitric oxide to nitrous oxide, and (iii) nitrous oxide to nitrogen. Gas chromatographic analyses revealed that each of these fractions reduced only one of the nitrogenous oxides. PMID- 4324804 TI - Efflux and the steady state in alpha-methylglucoside transport in Escherichia coli. AB - Efflux and the steady state in a group translocation system, the alpha methylglucoside (alphaMG) transport system, were investigated. The maximum intracellular level of alpha-methylglucoside is a function of a steady state. There is no inhibition of alphaMG influx as the intracellular pool of alphaMG, and alpha-methylglucoside-6-phosphate (alphaMGP) rises. This steady state has three components: alphaMG influx, action of an alphaMGP phosphatase, and alphaMG efflux. The phosphatase is the rate-limiting step (half-time = 5.0 min); thus, the true efflux rate (half-time = 2.0 min) cannot be simply measured from the kinetics of alphaMG loss from the cell. Under our steady-state conditions the percentage of intracellular radioactivity present as alphaMGP was 71%. Under conditions of zero influx, after an efflux of 12 min the percentage present as alphaMGP fell to 55%. However, when fluoride was present during the efflux period, the percentage of the sugar as alphaMGP increased to about 85%. Fluoride greatly inhibits both influx and phosphatase activity (half-time = 50 min). The efflux of alphaMG from the cell is apparently also fluoride-sensitive but to a lesser extent (half-time = 4.1 min). These data are summarized in a model describing the three components of the steady-state and effect of fluoride. PMID- 4324806 TI - Temperature control of phospholipid biosynthesis in Escherichia coli. AB - The higher the growth temperature of Escherichia coli cultures the greater is the proportion of saturated fatty acids in the bacterial phospholipids. When fatty acids are exogenously supplied to E. coli, higher growth temperatures will likewise increase the relative incorporation of saturated fatty acids into phospholipids. One of the steps in the utilization of fatty acids for phospholipid biosynthesis is, therefore, temperature-controlled. The temperature effect observed in vivo with mixtures of (3)H-oleate and (14)C-palmitate is demonstrable in vitro by using mixtures of the coenzyme A derivative of these fatty acids for the acylation of alpha-glycerol phosphate to lysophosphatidic and phosphatidic acids. In E. coli extracts, the relative rates of transacylation of palmityl and oleyl coenzyme A vary as a function of incubation temperature in a manner which mimics the temperature control observed in vivo. The phosphatidic acid synthesized in vitro shows a striking enrichment of oleate at the beta position analogous to the positional specificity observed in phospholipids synthesized in vivo. PMID- 4324805 TI - Effect of benzo(a) pyrene and piperonyl butoxide on formation of respiratory system, phospholipids, and carotenoids of Staphylococcus aureus. AB - Staphylococcus aureus formed an electron transport system when exponentially growing cells were aerated. Formation of the electron transport system occurred concomitantly with increases in the phospholipids and the carotenoids. The addition of piperonyl butoxide or benzo(a)pyrene at the onset of aeration (i) slowed the formation of the electron transport system, (ii) both inhibited cytochrome oxidase o synthesis and decreased its stability, (iii) simultaneously depressed the increase in total phospholipid (especially cardiolipin), and (iv) depressed the synthesis of the carotenoid rubixanthin. Benzo(a)pyrene was the more inhibitory of the two, both on the rate of synthesis of the electron transport system and on rubixanthin formation. Evidence obtained with the inhibitors suggested that inhibition of the lipid synthesis was related to the formation of the electron transport system. PMID- 4324807 TI - Induction of citrate transport in Bacillus subtilis during the absence of phospholipid synthesis. AB - Citrate transport can be induced in a glycerol-requiring mutant of Bacillus subtilis even after deprival of glycerol. Under these conditions de novo phospholipid synthesis is stopped although ribonucleic acid, deoxyribonucleic acid, and protein syntheses continue. It is concluded that the inducibility of bacterial transport systems must not necessarily require de novo phospholipid synthesis. PMID- 4324809 TI - Thermal activation of the antiviral activity of synthetic double-stranded polyribonucleotides. PMID- 4324808 TI - Specificity of a catabolic pathway--a lesson learned from indirect assays. AB - Studies with purified orcinol hydroxylase suggest that, contrary to previous conclusions, the enzymes of the orcinol pathway cannot transform analogous compounds to common metabolites. The substrate analogues of orcinol uncouple electron flow from reduced nicotinamide adenine dinucleotide to oxygen from the hydroxylation reaction catalyzed by orcinol hydroxylase. PMID- 4324810 TI - Immunologic reactivity to viral antigens in chickens infected with avian leukosis viruses. PMID- 4324811 TI - Transmission of avian myeloblastosis by BAI strain A virus ribonucleic acid. PMID- 4324812 TI - Repeated demonstration of a mouse leukemia virus after treatment with chemical carcinogens. PMID- 4324813 TI - Inhibition of growth of uninfected and rous sarcoma virus-infected chick-embryo fibroblasts by rifampicin. PMID- 4324814 TI - Suppression of tumor growth at the site of infection with living Bacillus Calmette-Guerin. PMID- 4324815 TI - Defective immunohematopoiesis in young-adult mice of the leukemia-prone AKR strain. PMID- 4324816 TI - Antibodies to early Epstein-Barr virus-induced antigens in Burkitt's lymphoma. PMID- 4324817 TI - Tumor immunity: impairment in tumor-bearing hosts. PMID- 4324818 TI - Seroepidemiologic studies of Epstein-Barr virus antibody in monkeys. PMID- 4324819 TI - [Correlation between gestational age, osseous age and other parameters of intrauterine growth]. PMID- 4324820 TI - [Distamycin A in the treatment of cutaneous localizations of herpes virus and of complications of jennerian vaccination]. PMID- 4324821 TI - Muscle surface pH: a new parameter in the monitoring of the critically ill child. PMID- 4324822 TI - Effect of vibration on the adrenocortical function. PMID- 4324823 TI - Experimental cerebral glio-sarcomas in mice. PMID- 4324824 TI - [Clinical peculiarities of the epidemic of poliomyelitis caused by type 3 of poliovirus in 1968]. PMID- 4324825 TI - Batrachotoxin: chemistry and pharmacology. AB - Batrachotoxin has been shown to be a pyrrolecarboxylic ester of a novel steroidal base with unique and selective actions on a variety of electrogenic membranes. The effects of batrachotoxin in neuromuscular preparations both pre- and postsynaptically, in nerve axons, in superior cervical ganglion, in heart Purkinje fibers, and in brain slices appear to be due to the selective and irreversible increase in permeability of membranes to sodium ions. The subsequent effects of this increase in Na(+) permeability evoked by batrachotoxin-such as membrane depolarization, enhanced spontaneous transmitter release, muscle contracture, and enhanced formation of cyclic AMP in brain slices-may be blocked reversibly by tetrodotoxin. PMID- 4324826 TI - [Surface organ-- specific mouse liver antigens in hepatomas]. PMID- 4324828 TI - [Possibilities and limitations of the treatment in the general practice]. PMID- 4324827 TI - [Modification of the total and isoenzyme activity of human phosphomonoesterases by several buffer solutions at various pH values. 5th communication about thin layer electrophoretic separated phosphatases]. PMID- 4324829 TI - [Effect of the deproteinizing agent on the determination of blood sugar by the glucose oxidase-Perid method]. PMID- 4324830 TI - The synthesis of physiologically active peptides. PMID- 4324831 TI - ACTH test for adrenocortical insufficiency. PMID- 4324832 TI - [Studies on swine. 32. The status of glucose concentration in plasma and erythrocytes after administration of ACTH and glucocorticosteroids]. PMID- 4324833 TI - [Studies on swine. 33. The pyruvate concentration in plasma after administration of ACTH and glucocorticosteroids as well as after bilateral adrenalectomy]. PMID- 4324834 TI - In vivo depression of hepatic succinoxidase by sulfhydryl compounds. PMID- 4324835 TI - Effect of hydroxy analogs of coenzyme Q on DPNH- and succin-oxidase activities of yeast mitochondria. PMID- 4324836 TI - Chlorpropamide and tolbutamide inhibition of adenosine 3'5' cyclic monophosphate phosphodiesterase. PMID- 4324837 TI - Cyclic GMP stimulation and inhibition of cyclic AMP phosphodiesterase from thymic lymphocytes. PMID- 4324838 TI - Identification of virus-specific RNA in cells infected with Rous sarcoma virus. PMID- 4324839 TI - ATP synthesis driven by inorganic pyrophosphate in Rhodospirillum rubrum chromatophores. PMID- 4324840 TI - Cyclic 3',5'-nucleotide phosphodiesterase, IV. Two enzymes with different properties from brain. PMID- 4324842 TI - Effect of irradiation on the maturation of Wilms' tumor. PMID- 4324841 TI - The influence of angiotensin infusion on the urine composition in individual kidney function tests. AB - Thirty-two patients with hypertension were given a pressor dose of angiotensin in the course of individual kidney function tests. In eight patients with unilateral renal artery stenosis the differences in urine sodium and creatinine concentration between the affected and the nonaffected kidney did not become greater with angiotensin infusion. In four patients with unilateral pyelonephritis and falsely positive individual kidney function tests, these tests became normal following angiotensin infusion. It is concluded that angiotensin infusion is not a useful means of improving the results of individual kidney function tests. PMID- 4324843 TI - Carcinoid-islet cell tumor of the duodenum and associated multiple carcinoid tumors of the ileum. An electron microscopic study. PMID- 4324844 TI - [Experiences with virostatic therapy of herpetic keratitis]. PMID- 4324846 TI - [Gerontopsychiatric departments in a mental hospital]. PMID- 4324845 TI - [Ocular herpes zoster. A review]. PMID- 4324847 TI - [Cytodiagnosis in secerning breasts]. PMID- 4324848 TI - [Therapy of obstructing cardiac rhythm disorders by pacemaker implantation]. PMID- 4324849 TI - [Enzymes in childhood]. PMID- 4324850 TI - [Immune response in virus diseases on the model of smallpox]. PMID- 4324851 TI - [Metabolism of 25-hydroxycholecalciferol in healthy and nephrectomized patients]. PMID- 4324852 TI - Diabetes mellitus--present problems and new research. VI. Nephropathy and neuropathy. PMID- 4324853 TI - [Enzyme activities in adipose tissue. Comparison in the rat, swine and man]. PMID- 4324854 TI - Synaptic transmission in the brain. PMID- 4324856 TI - Signal transmission in random spike trains with applications to the statocyst neurons of the lobster. PMID- 4324855 TI - [Synthesis, storage, and release of the adrenergic neurotransmitter]. PMID- 4324857 TI - [Clinical and statistical contribution on feminizing ovarian tumors (granulosa cell and theca cell tumors]. PMID- 4324858 TI - Structure and activity of muscarinic stimulants. PMID- 4324859 TI - Common genetic alterations of RNA tumour viruses grown in human cells. PMID- 4324860 TI - Effect of ACTH and dibutyryl cyclic AMP on catecholamine synthesizing enzymes in the adrenals of hypophysectomized rats. PMID- 4324861 TI - Corticotrophin releasing factor in hypophysial portal blood of rats. PMID- 4324862 TI - What price the crusade for cancer research? PMID- 4324863 TI - Enigma of satellite DNA variations. PMID- 4324865 TI - Evidence for a cyclic nucleotide-phosphodiesterase with high specificity for cyclic uridine-3',5'-monophosphate in rat adipose tissue. PMID- 4324864 TI - DNA ligase and exonuclease activities in virions of rous sarcoma virus. PMID- 4324866 TI - [An unusual etiology for "neuropathy" OF THE LUMBOSACRAL PLEXUS]. PMID- 4324867 TI - [Clinical and pathogenetic significance of hypocalcemia in rachitis caused by vitamin D deficiency]. PMID- 4324868 TI - [Rehabilitation in cases of peroneal nerve paralysis in infants]. PMID- 4324869 TI - On the interaction between thymidylic acid and sulfhydrylamine radioprotectors. PMID- 4324870 TI - Structure-function studies of the aminothiol radioprotectants. The effect of carbon chain length in mercaptoethylamine homologs. PMID- 4324871 TI - Effects of radioprotective aminothiols in vivo on the sedimentability of mitochondria. PMID- 4324872 TI - Morphological changes in cellular organelles of x-irradiated bacteria-free grasshopper diapause embryos. PMID- 4324873 TI - Radical processes following gamma-irradiation of frozen concentrated matrices of heparin and dextran sulphate. PMID- 4324874 TI - [Primary osteochondritis of the hip. IV. Radiological study]. PMID- 4324875 TI - [Psychophysiologic study of nightmares]. PMID- 4324876 TI - 125I-labelling of angiotensin I and II. PMID- 4324877 TI - Relationship between trauma, plasma corticosterone and reticuloendothelial function in anaesthetized mice. PMID- 4324878 TI - Variations in plasma renin activity and urinary aldosterone excretion in normal subjects after salt restriction and acute pituitary inhibition with 6-dehydro-16 methylene hydrocortisone. PMID- 4324879 TI - Radioimmunological determination of plasma renin activity during the menstrual cycle and during acute progesterone administration. PMID- 4324880 TI - Plasma renin activity in Wilms' tumour. PMID- 4324881 TI - Peripheral facial palsy. Functional diagnosis. PMID- 4324882 TI - [Pathological, some biochemical and cytometric findings in a case of acromegaly]. PMID- 4324883 TI - Identification of isolates of Clostridium perfringens types C and D by agglutination and fluorescent-antibody methods. AB - Agglutination and fluorescent-antibody methods were employed for screening Clostridium perfringens types C and D from 393 isolates of this organism. All of 50 strains which were isolated in Japan and were agglutinable with an antiserum prepared against a stock strain of type C no. 3182 toxigenically belonged to type C, but the antiserum showed no cross-agglutination with any of type C strains isolated in Denmark. All of the latter strains, however, were agglutinated by an antiserum prepared against a Danish strain, CWC11. Of 64 strains, showing heat labile agglutinability by type D antiserum L9, 22 strains were toxigenically identified as type D strains which can be divided into three groups by the heat stable antigens; no strains which were L-agglutination-positive but O agglutination-negative were epislon-toxigenic. All of 13 strains, the heat-stable antigen of which was agglutinable by a type D antiserum VX81, were toxigenically type D strains. The results of fluorescent-antibody tests were almost in agreement with those of agglutination test with type C strains and completely with those of the O-agglutination test with type D strains. No beta-, epsilon- or delta-toxigenicity could be demonstrated in strains which were not agglutinated by our test sera for types C and D strains. Further examination of cultural properties of Japanese and Danish type C strains revealed that the two groups were considerably different in urease production, capsule formation, and delta- and alpha-toxigenicities. PMID- 4324884 TI - Medium for toxin production by Clostridium perfringens in continuous culture. AB - A tryptone-salts medium for continuous growth and alpha toxin production of Clostridium perfringens type A in an adapted chemostat is described. In such steady-state cultures, fermentative and biochemical activity of C. perfringens remained unchanged. Toxigenic ability to produce alpha, theta, and nu toxins was preserved. PMID- 4324885 TI - Comparison of media for the enumeration of Clostridium perfringens. AB - For the enumeration of viable vegetative cells and spores of Clostridium perfringens, noncommercial (laboratory prepared) sulfite-polymyxin-sulfadiazine (SPS) agar, tryptone-sulfite-neomycin (TSN) agar, and Shahidi-Ferguson perfringens (SFP) agar were statistically compared to SPS agar without antibiotics. The selectivities of these four media were also evaluated on the basis of their ability to inhibit the growth of pure cultures of a variety of other organisms. The average recovery of vegetative cells of 10 strains of C. perfringens with SFP agar was not significantly higher than with SPS agar with 10(4) organisms per g, but with 10(6) organisms per g it yielded significantly higher recoveries than SPS agar. TSN agar yielded significantly lower recoveries at both inoculum levels. SFP agar gave significantly higher recoveries of spores than SPS and TSN agars. Average plate counts of spores in SFP agar were 75% as high as in SPS agar without antibiotics, but only 45% of the spores grew in SPS agar and 25% in TSN agar. TSN agar was the most selective of the three media, but the selectivity of SPS agar approached that of TSN agar under the test conditions. SFP agar, which was the least selective of the media, allowed growth to some extent of nearly all of the facultative anaerobes tested. PMID- 4324886 TI - Assay of chick interferons by the inhibition of viral ribonucleic acid synthesis. AB - A method for assaying chick interferons by their inhibition of viral ribonucleic acid synthesis was devised and evaluated. The technique yielded results faster and had more flexibility than other methods with similar sensitivity and reproducibility. PMID- 4324887 TI - [Alcoholic delirium and dream sleep. Results of polygraphic EEG-recording during night-sleep in patients following alcoholic delirium]. PMID- 4324888 TI - [Laboratory differentiation of variola from varicella]. PMID- 4324889 TI - [Electron microscopic studies on salivary gland neoplasms]. PMID- 4324890 TI - Staphylococcal nuclease (Foggi strain). II. The amino acid sequence. PMID- 4324891 TI - Pyruvate-ferredoxin oxidoreductase. IV. Studies on the reaction mechanism. PMID- 4324892 TI - Characterization of cyclic nucleotide phosphodiesterases of rat tissues. PMID- 4324893 TI - Reaction of the catalytic subunit of Escherichia coli aspartate transcarbamylase with permanganate ion, a reactive structural analogue of phosphate ion. PMID- 4324894 TI - The structure of the glycopeptide of human gamma G myeloma proteins. PMID- 4324895 TI - Nicotinate phosphoribosyltransferase of yeast. Purification and properties. PMID- 4324896 TI - Purification and properties of adenyl cyclase from Streptococcus salivarius. PMID- 4324897 TI - The effects of protein conformation on the heme symmetry in high spin ferric heme proteins as studied by electron paramagnetic resonance. PMID- 4324898 TI - Studies on the stability of oxyhemoglobin A and its constituent chains and their derivatives. PMID- 4324899 TI - Sulfheme proteins. I. Optical and magnetic properties of sulfmyoglobin and its derivatives. PMID- 4324901 TI - Effect of modification of N-acetylneuraminic acid on the binding of glycoproteins to influenza virus and on susceptibility to cleavage by neuraminidase. PMID- 4324900 TI - Sarcoplasmic reticulum. XIV. Acetylphosphate and carbamylphosphate as energy sources for Ca++ transport. PMID- 4324902 TI - Effect of modification of N-acetylneuraminic acid on the biological activity of human and ovine follicle-stimulating hormone. PMID- 4324903 TI - Stimulation of peripheral lymphocytes by allogeneic and autochthonous mononucleosis lymphocyte cell lines. PMID- 4324904 TI - [Evoked activities at the lumbar level by stimulation of nerves of the anterior paw in the spinal cat. I. Activities in the ventral horns]. PMID- 4324905 TI - [Evoked activities at the lumbar level due to stimulation of nerves of the anterior paw in the spinal cat. II. Activities in the dorsal horns]. PMID- 4324906 TI - [Corticotropic activity of the grafted pituitary gland in green frogs]. PMID- 4324907 TI - [Study of the interrenal tissue of the green frog Rana esculenta L., after ectopic graft of the pituitary gland into the eye, adrenal gland and testis]. PMID- 4324908 TI - [Effects of surgical stress on renal neoglucogenesis during metabolic acidosis in rats]. PMID- 4324909 TI - [Vasomotor response relative to variations of frequency and duration of equiquantal stimulation]. PMID- 4324911 TI - [Effects of hydrocortisone and A.C.T.H. feedback on catecholamines in the diencephalon in rats]. PMID- 4324910 TI - [Compared dynamic of gas and ion exchanges in an experimental exsudate induced by cristobalite]. PMID- 4324913 TI - [Action of hemicholinium on a central synapse in Aplysia]. PMID- 4324912 TI - [Effect of hydrocortisone and ACTH on the level of catecholamines in the adrenal gland and heart after prolonged hypothermia in rats]. PMID- 4324914 TI - A survey of feline viral rhinotracheitis and feline picornavirus infection in Britain. PMID- 4324915 TI - [Neurogenic ulcerating acropathy (acroosteolysis syndrome)]. PMID- 4324916 TI - Lack of correlation between conversion of RNA tumour viruses and increased agglutinability of cells by concanavalin A and wheat germ agglutinin. PMID- 4324917 TI - Reverse transcriptase in human milk virus. PMID- 4324918 TI - RNA-dependent DNA polymerase activity in virus-like particles isolated from human milk. PMID- 4324919 TI - [Prostaglandins and neurotransmission]. PMID- 4324920 TI - [Myelography--radiculography]. PMID- 4324921 TI - [Analysis of isoindoline derivatives. 7. Determination of isoindolin arylsulphonylurea derivatives]. PMID- 4324922 TI - [Study of the surviving kidney of patients nephrectomized and irradiated for neoplasms in the pediatric age]. PMID- 4324923 TI - Angiotensin II: rapid localization in nuclei of smooth and cardiac muscle. AB - Five to ten nanograms of labeled angiotensin II rapidly injected in the left ventricle of adult rats was found to induce significant ultrastructural endothelial changes, resulting in net increases in number and size of pinocytotic vesicles as well as widening of intercellular spaces. This effect was followed by preferential localization of the compound in the nuclear zone of vascular and cardiac muscle cells. The selective cellular localization of angiotensin II suggests that this vasoactive agent or some of its metabolic fragments may have specific effects on nuclear function. PMID- 4324924 TI - Antiviral resistance by the polyinosinic acid-poly (1-vinylcytosine) complex. AB - The antiviral activities of analogs of the double-stranded complex of polyinosinic and polycytidylic acids [poly(I).poly(C)], which is a potent interferon inducer, have been studied. Structural changes that modify the polymer backbone substantially, such as loops or 2' --> 5' phosphodiester bonds, lead to decreased antiviral activity. Unexpectedly, however, the complex of polyinosinic acid and poly(1-vinylcytosine), which is only a much more distantly related analog of poly(I) . poly(C), shows high activity. It is postulated that the high activity is related to the reduction of the charge/mass ratio and to the existence of this complex in an aggregated state; these are two factors that generally enhance the uptake of compo unds by cells. PMID- 4324925 TI - A survey of antibodies to some respiratory viruses in the sera of pigs. PMID- 4324926 TI - [Defectiveness of Rous sarcoma virus (strain D-5)]. PMID- 4324927 TI - [Transplacental blastomogenic action of N-nitrosodiethylamine in mice]. PMID- 4324928 TI - [Differences in the process of survival of artificial metastases in the liver and the lung]. PMID- 4324929 TI - [Experimental neoplasms in fish]. PMID- 4324930 TI - [Corticotropic effectiveness and allergenicity of the synthetic ACTH tetracoacetid synacthen depot]. PMID- 4324931 TI - [Additional conductive tissue in the goldern hamster heart]. PMID- 4324932 TI - Effect of angiotensin on corticoid production of the rat adrenal in vitro. PMID- 4324934 TI - Clinical pathological study of Wilm's tumour. PMID- 4324933 TI - The effect of lipid peroxidation on liver microsomes. PMID- 4324935 TI - Respiratory infection with parainfluenza 1, Sendai virus in gnotobiotic and conventional mice. PMID- 4324936 TI - Synergistic effect in viral-bacterial infection. 4. The leukocyte response to parainfluenza virus infection in the respiratory tract of mice, and the influence of antibiotics on the development of infection. PMID- 4324938 TI - Cardiac growth and respiratory enzyme levels in male rats subjected to a running program. PMID- 4324937 TI - Inhibitory action of intracoronary prostaglandin E 1 on myocardial lipolysis. PMID- 4324939 TI - Mitochondrial metabolism of succinate, beta-hydroxybutyrate, and alpha ketoglutarate in hemorrhagic shock. PMID- 4324940 TI - Conversion of angiotensin I to angiotensin II in peripheral vascular beds of the rat. PMID- 4324941 TI - Glycolytic and gluconeogenic enzyme levels in pre- and postnatal pigs. PMID- 4324942 TI - Inhibition of renin secretion by systemic and intrarenal angiotensin infusion. PMID- 4324943 TI - Mechanism of action of angiotensin cofactor. PMID- 4324944 TI - Membrane activity in guinea pig gastric sling muscle: a nerve-dependent phenomenon. PMID- 4324945 TI - Renin isozymes of extrarenal origin. PMID- 4324946 TI - Serum proteins and amino acids in asbestosis. PMID- 4324947 TI - Peripheral polyneuropathy among patients with burns. PMID- 4324949 TI - The release of corticotrophin and vasopressin in the foetal sheep in response to haemorrhage. PMID- 4324948 TI - 75se-selenomethionine in the scintiscan diignosis of primary hepatocellular carcinoma. AB - Forty-eight patients with ;cold areas' on (99m)Tc sulphur colloid liver scintiscans were scanned again using (75)Se-selenomethionine. In 11 patients with primary hepatocellular carcinoma considerable uptake of (75)Se-selenomethionine could be demonstrated in the area of the tumour and uptake of (75)Se selenomethionine was also observed over extrahepatic metastases in two of these cases. In contrast uptake was low in cholangiocellular carcinoma, Kupffer cell sarcoma, and secondary hepatic deposits (excepting melanoma metastases). No cause for the ;cold area' on the (99m)Tc scan could be discovered in 16 of 25 patients with cirrhosis and in these patients the uptake of the two isotopes in the area of the ;false positive' filling defect was almost equal. Positive identification of primary hepatocellular tumours using this dual scanning technique can be of value in determining and assessing treatment by surgery or cytotoxic therapy. PMID- 4324951 TI - Cyclic AMP, bradykinin and sweat gland function. PMID- 4324950 TI - Autonomic connexions of the area postrema in the central cardiovascular response to angiotensin II. PMID- 4324952 TI - On and off retinal cells in parallel channel neural communication. PMID- 4324953 TI - [Physiopathology of renal hypertension]. PMID- 4324954 TI - [Electroencephalographic studies of a new methaqualone combination]. PMID- 4324955 TI - [Malignant synovial tumor in the knee joint. Diagnosis, treatment and results after 16 years]. PMID- 4324956 TI - [Effect of lipid peroxidation on liver microsomes]. PMID- 4324957 TI - [Recent acquisitions in chronophysiology and chronopathology of corticotropin secretion]. PMID- 4324958 TI - [Hepatic embryoma]. PMID- 4324959 TI - [Viral influenza, influenzal infection and diagnostic tasks of regional influenza laboratories]. PMID- 4324960 TI - [Acute intermittent porphyria (our personal observations in a family)]. PMID- 4324961 TI - [Sex differences in the ultrastructure of the rat adrenal cortex]. PMID- 4324962 TI - Nervous disturbances in horses in relation to infection with equine rhinopneumonitis virus. PMID- 4324963 TI - Interaction of veronal, pyrophosphate, citrate and protein with lactate dehydrogenase isoenzyme determination and kinetics. PMID- 4324964 TI - Equine coital exanthema. Isolation of a virus and transmission experiments. PMID- 4324965 TI - Quinone interaction with the respiratory chain-linked NADH dehydrogenase of beef heart mitochondria. II. Duroquinone reductase activity. PMID- 4324966 TI - The acceptor specificity of flavins and flavoproteins. II. Free flavins. PMID- 4324967 TI - Mutant strains of Rhodopseudomonas spheroides which form photosynthetic pigments aerobically in the dark. Growth characteristics and enzymic activities. PMID- 4324968 TI - An effect of trypsin on the actin-myosin interaction. PMID- 4324969 TI - Mitochondrial calcium uptake in the perfused contracting rat heart and the influence of epinephrine on calcium exchange. PMID- 4324970 TI - Interaction of formate esters with viral RNA and viral polymerase. PMID- 4324971 TI - Thymidine phosphorylation and thymidylate kinase in developing breast muscle of normal and dystrophic chickens. PMID- 4324972 TI - The melanocyte stimulating activity of several commercial corticotrophin preparations. PMID- 4324973 TI - Pharmacological aspects of the unnatural amino acids and amines. Introductory remarks. PMID- 4324974 TI - Tyrosine hydroxylase inhibitors. PMID- 4324975 TI - 6-hydroxydopamine, 6-hydroxydopa and degeneration of adrenergic nerves. PMID- 4324976 TI - Unnatural amino acids as precursors of false transmitters. PMID- 4324977 TI - Clinical implications of unnatural amino acids and amines. PMID- 4324978 TI - Cell fusion and virus rescue. PMID- 4324979 TI - Linkage studies employing mouse--man somatic cell hybrids. PMID- 4324980 TI - Regulation of differentiation in cell hybrids. PMID- 4324981 TI - Mammalian somatic cell hybrids and their susceptibility to viral infection. PMID- 4324982 TI - Quartz and graphite filament reinforced polymer composites for orthopedic surgical application. PMID- 4324983 TI - Site of adrenaline blockade in the superior cervical ganglion of the rabbit. AB - 1. The blocking action of adrenaline on the superior cervical ganglion of the rabbit was investigated with intracellular recording techniques.2. Adrenaline (10(-5)M) blocked initiation of post-synaptic action potentials and decreased the amplitude of excitatory post-synaptic potentials (e.p.s.p.s), but did not hyperpolarize the post-synaptic membrane.3. The depressant action of adrenaline was antagonized by phenoxy-benzamine and dihydroergotamine.4. Acetylcholine depolarizations from iontophoretic ACh were not affected by adrenaline.5. Adrenaline decreased the frequency of miniature excitatory post-synaptic potentials (m.e.p.s.p.s) and decreased the quantal content of e.p.s.p.s in a low [Ca(2+)]: [Mg(2+)] media.6. It was concluded that adrenaline blocks ganglionic transmission by acting at an alpha-adrenoceptive site in the presynaptic nerve terminals. PMID- 4324985 TI - Noradrenaline release from isolated muscles of the nictitating membrane of the cat. AB - 1. When the splanchnic nerves were stimulated in the cat for periods of up to 2 hr, the amount of adrenaline taken up by the nictitating membrane was very small; the highest figure was 0.37 mug/g, corrected for losses.2. The noradrenaline (NA) stores of the isolated medial muscle of the nictitating membrane were labelled with [(3)H]NA, and field stimulation of single muscles was carried out in a small organ bath. A stimulation period of 5 min with supramaximal shocks delivered at a frequency of 25/sec produced a mean release of NA into the bath fluid of 0.46 +/- 0.13 mug/g (uncorrected). Phenoxybenzamine, 10 mug/ml., increased this figure by a factor of 2-3.6. When corrections were made for the amount of transmitter metabolized before it could be collected, 47% of the tissue content of NA were shown to be released during the 5 min stimulation of the normal membrane, and about 55% in the presence of phenoxybenzamine. Prolonged stimulation of a phenoxybenzamine-treated membrane was apt to lead to loss of tissue stores of NA.3. Calculation of the degree of labelling of the NA in the tissue, and of NA released by stimulation, indicated that about 21% of endogenous NA had been replaced by labelled compound both in the tissue and in the overflow.4. Transmitter release per pulse was estimated by applying 720-1330 shocks at frequencies of 4 or 6/sec to membranes exposed to phenoxybenzamine. Mean release of NA per shock and per g tissue was 1.3 ng (corrected for losses). This represents 3.5 x 10(-4) of the tissue content determined at the end of the experiment. PMID- 4324986 TI - Resting concentration of angiotensin II-like activity in the arterial blood of rabbits of different ages. PMID- 4324984 TI - Vasoactive hormones in endotoxin shock: a comparative study in cats and dogs. AB - 1. Entamoeba coli endotoxin was administered intravenously to cats and dogs.2. The changes in circulating levels of catecholamines and angiotensin following endotoxin were assayed by a continuous superfusion technique.3. The response of the dog was characterized by an immediate sustained rise in angiotensin levels and a later variable rise in catecholamine levels.4. The response of the cat was characterized by an early rise in catecholamine levels and a later rise in angiotensin levels.5. It is concluded that this species difference may reflect the relative importance of renin-angiotensin and sympatho-adrenal systems of dogs and cats, respectively. PMID- 4324987 TI - An effect of angiotensin on sodium pump activity of rat kidney cortex. PMID- 4324988 TI - The effects of calcium and magnesium on potentiation and depression of extracellularly recorded EPSPs in the olfactory cortex of the guinea-pig. PMID- 4324989 TI - The effect of norepinephrine on cyclic AMP levels in discrete regions of the developing rabbit brain. PMID- 4324990 TI - Inhibition by prostaglandin E1 of parasympathetic neurotransmission in the rabbit hheart. PMID- 4324991 TI - Acute toxicity of methyl mercury on glycolytic intermediates and adenine nucleotides of rat brain. PMID- 4324992 TI - Exfoliative cytology in following the effectiveness of chemotherapy of malignant neoplasms of the orofacial region. PMID- 4324993 TI - Subcutaneous tumours induced by Bryan strain chicken Rous sarcoma in thymectomized and ALS-treated hamsters. PMID- 4324994 TI - A further note on the ultrastructure of myeloma plasmacytes. PMID- 4324995 TI - Ribonucleic acid biosynthesis in the Kirkman-Robbins hamsters hepatoma. PMID- 4324996 TI - Ovarian tumor classification. PMID- 4324997 TI - [Biogenic amines and sleep]. PMID- 4324998 TI - Isolation of a polyoma-nucleoprotein complex from infected mouse-cell cultures. AB - A complex containing polyoma (py) DNA and protein (py complex) was isolated from polyoma-infected mouse-cell cultures. The complex sedimented unimodally at about 55 S. When labeled for long periods (2-3 hr) between 20 and 40 hr after infection, most of the [(3)H]DNA in the py complex was in the form of covalently closed, circular polyoma DNA (component I). When labeled for 5 min, the [(3)H]DNA in the py complex was nicked in one or both of the strands, as shown by alkaline sucrose gradient centrifugation. Under all conditions studied, no free py DNA was extracted from mouse cells by the two methods described. PMID- 4324999 TI - Simian virus 40 integration site in an adenovirus 7-simian virus 40 hybrid DNA molecule. AB - The E46(+) strain of Adenovirus 7 is a mixed-virus population containing defective Adenoviurs 7-SV40 hybrid particles and helper, nonhybrid Adenovirus 7 particles. We have applied electron microscopic mapping techniques to obtain a physical map of the genome of the hybrid particles present in E46(+)PL1, a substrain of E46(+) derived from a single two-hit plaque. DNA molecules extracted from purified E46(+)Pl1 virions were found to be linear duplexes, with a mean lenght of 10.9 mum. When these molecules were denatured and renatured, a unique heteroduplex was formed that presumably derived one of its strands from an Adenovirus 7-SV40 hybrid molecule and the other from a nonhybrid Adenovirus 7 molecule. This heteroduplex was double-stranded, except for a short region near one end where the two strands were not paired. On the basis of measurements of the lengths of the single-and double-stranded regions in the heteroduplex, the structure of the Adenovirus 7-SV40 hybrid genome can be reconstructed as follows: The hybrid genome contains 16% less Adenovirus 7 DNA than the nonhybrid Adenovirus 7 genome. This deletion consists of the segment of DNA that maps between 0.05 and 0.21 molecular lenghts in the nonhybrid Adenovirus 7 DNA molecule. The deleted DNA has been partially replaced by an amount of heterologous DNA equivalent to 75% of the complete SV40 genome. A model for the generation of the hybrid genome is presented. PMID- 4325000 TI - Double-stranded poliovirus RNA inhibits initiation of protein synthesis by reticulocyte lysates. AB - Infection of HeLa cells with poliovirus results in an inhibition of host-cell protein synthesis. Cytoplasmic extracts from infected cells contian an activity that inhibits initiation of protein synthesis in vitro by rabbit reticulocyte lysates. This inhibitory activity has been purified and characterized, and is shown to reside in poliovirus double-stranded RNA. The intact double-stranded molecule is not essential for inhibitory activity. PMID- 4325001 TI - Deficiency of uncoupler-stimulated adenosine triphosphatase activity in tightly coupled hepatoma mitochondria. AB - Tightly coupled mitochondria from the well-differentiated hepatoma 7800 failed to exhibit a significant 2,4-dinitrophenol-activated ATPase activity at concentrations of uncoupler sufficient to completely inhibit oxidative phosphorylation. ATPase activity could not be maximally activated by uncoupling agents more potent than 2,4-dinitrophenol, such as carbonylcyanide p trifluoromethoxyphenylhydrazone and 5-chloro, 3-tert-butyl, 2'-chloro, 4' nitrosalicylanilide, nor by Mg(++) after the following treatments: sonication, freezing, detergent lysis, and digestion with trypsin. Gel electrophoresis patterns of the membrane proteins of the hepatome mitochondria revealed neither an absence of any one of the three different types of ATPase subunits characteristic of the homogeneous enzyme purified from normal liver mitochondria, nor a deficiency of the oligomeric molecule. Taken together, these data strongly suggest that the supramolecular structure of the membrane ATPase complex of mitochondria from hepatoma 7800 is altered in such a way that its capacity for ATP hydrolysis is severely diminished. PMID- 4325003 TI - Covalent attachment of diethylstilbestrol to glutamate dehydrogenase: implications for allosteric regulation. AB - An affinity labeling reagent for the estrogenic-binding site of bovine liver L glutamate dehydrogenase (EC 1.4.1.3) was prepared by conversion of diethylstilbestrol to its alkylating analogue, bromoacetyldiethylstilbestrol. Under standard assay conditions, the analogue acted as a reversible allosteric ligand with regulatory activity much like that of diethylstilbestrol. However, incubation of the enzyme with the alkylating agent in the presence of DPNH resulted in a permanent decrease in glutamate (X form) and an increase in alanine (Y form) activities, and in covalent attachment of diethylstilbestrol in the ratio of 1 mol per subunit (of particle weight 52,000). The brominated analogue behaved as an affinity label that mimicked the allosteric effects of diethylstilbestrol. Diethylstilbestrol protection of the enzyme against alkylation by bromoacetylated sterol suggested competition for the same binding site, while ADP protection indicated a shift of protein equilibrium into the X form. The diethylstilbestrol-enzyme compound was desensitized (relative to the native enzyme) to allosteric reagents such as ADP and GTP. The results were consistent with conformational freezing of the modified protein molecule into the Y form. PMID- 4325002 TI - Phosphorylation of ribosome-associated protein by an adenosine 3':5'-cyclic monophosphate-dependent protein kinase: location of the microsomal receptor and protein kinase. AB - In the adrenal cortex, the adenosine 3':5'-cyclic monophosphate (cAMP)-receptor protein and the cAMP-dependent protein kinase are located in both the cytosol and endoplasmic reticulum. The cAMP-dependent protein kinase from the cytosol catalyzes the phosphorylation of ribosome-associated protein. Ribosomes washed in 0.5 M NH(4)Cl retain the substrate of the protein kinase reaction, but are dependent on the NH(4)Cl extract for in vitro protein synthesis. Dissociation of the 80S ribosomes by 0.88 M KCl, however, releases the ribosome-associated (protein) substrate of the phosphorylation reaction. PMID- 4325005 TI - Quantitative in vitro measurement of simian virus 40 tumor-specific antigens. AB - Humoral antibodies, specific for the SV40 tumor-specific transplantation antigen, can be detected by an in vitro cytotoxic assay. (51)Cr-labeled SV40-transformed target cells are selectively killed in the presence of specific antibody and rabbit complement. Inhibition of cytotoxicity can be used to measure the antigen concentration and specific activity on different SV40-transformed cell lines. The assay described has several advantages when compared to other methods currently available to detect the specific SV40 antigen: it is simple, rapid, objective, reproducible, and quantitative. PMID- 4325006 TI - The laboratory investigation of acute paralysis. PMID- 4325004 TI - Antibody to the RNA-dependent DNA polymerase of mammalian C-type RNA tumor viruses. AB - Sera from rats bearing transplantable tumors induced by murine C-type tumor viruses contain an inhibitor of the activity of the viral RNA-dependent DNA polymerase. The inhibitor is shown to be an immunoglobulin (IgG) directed against the enzyme. Antiserum made in rabbits against partially purified murine leukemia virus polymerase also inhibits the polymerases of other mammalian C-type RNA containing tumor viruses. Thus, the polymerases from different mammalian tumor viruses are antigenically related. PMID- 4325007 TI - [On virilizing lipid-cell tumors of the ovary]. PMID- 4325008 TI - The application of negative contrast electron microscopy to routine veterinary virus diagnosis. PMID- 4325009 TI - Alterations in 3H-estradiol distribution following portacaval shunt. PMID- 4325010 TI - Serological evidence of the presence of haemagglutinating-encephalitis virus in Northern Ireland. PMID- 4325012 TI - [Foot and mouth disease virus in ultrathin sections]. PMID- 4325011 TI - [Identification of types and variants of foot-and-mouth disease virus]. PMID- 4325013 TI - [The effect of temperature during passage on the properties of attenuated foot and mouth disease virus]. PMID- 4325014 TI - [Interference and sensitivity of virulent and attenuated foot-and-mouth disease virus to interferon]. PMID- 4325015 TI - [Purification of cultured foot-and-mouth disease virus]. PMID- 4325016 TI - Hepatic lipid changes during liver regeneration in the rat. PMID- 4325017 TI - Parathyroid hormone action: definition of problems. PMID- 4325018 TI - Ionic and hormonal control of calcium homeostasis. PMID- 4325019 TI - Method for typing antisera to Herpesvirus hominis by indirect hemagglutination inhibition. AB - A test for typing antisera to Herpesvirus hominis that uses the method of indirect hemagglutination inhibition is described. The test, which is based upon the differential absorption of herpes antisera by preparations of type 1 and type 2 antigens, is rapidly and easily performed. The results permit some conclusions to be drawn regarding the antigenic relationships between the two virus types. Some of the practical limitations of the test are discussed. PMID- 4325020 TI - Concentration and purification of viruses by adsorption to and elution from insoluble polyelectrolytes. AB - Acid-resistant, nonenveloped viruses belonging to the enterovirus, reovirus, and adenovirus groups were readily concentrated on PE60, an insoluble cross-linked polyelectrolyte based on isobutylene maleic anhydride. Hydrolysis of PE60 by NaOH increased its capacity to adsorb viruses. Hydrogen ion levels played an important role in virus concentration; optimal pH levels for maximal virus adsorption were between pH 3.0 and 4.5. Undiluted virus was easily concentrated from large volumes on PE60, and the adsorbed virus was readily eluted at pH 8 to 9. PMID- 4325022 TI - Semi-micro, dye-binding assay for rabbit interferon. AB - The semi-micro method for interferon assay was based on quantitation of inhibition of cytopathic effects in 6-mm wells. Cultures were exposed to interferon dilutions, challenged with vesicular stomatitis virus, and stained with methylrosanaline chloride. The bound dye was then eluted and measured colorimetrically. The method was more sensitive than the plaque-inhibition method and was extremely economical. Culture age was the most important factor affecting reproductibility. PMID- 4325021 TI - Production and evaluation of a purified adenovirus group-specific (hexon) antigen for use in the diagnostic complement fixation test. AB - A simple procedure for the production of large volumes of purified adenovirus group-specific complement-fixing (CF) (hexon) antigen by selective adsorption to and elution from CaHPO(4) is described. Results of immunodiffusion tests, electrophoresis, electron microscopy, and tests for hemagglutination and infectivity indicate that the purified antigen consisted of a single virus component (hexon). The purified product contained little host materials. Unlike the crude virus harvest usually employed for serodiagnostic CF tests, the purified antigen demonstrated no anticomplementary activity and did not develop such activity during storage. The purified antigen was equal to or slightly more sensitive than crude virus harvests for serodiagnosis of adenovirus infections. PMID- 4325023 TI - Studies on Japanese B encephalitis virus vaccines from tissue culture. XI. Immune mechanism and evaluation of the mouse challenge potency test. AB - A study was carried out to evaluate the reliability of and to determine the mechanism involved in an antigen extinction mouse intraperitoneal (ip) challenge test for potency of a cell culture vaccine for Japanese B encephalitis, a modification of a test originated by Sabin for a mouse brain vaccine. Some comparisons were made with the official Japanese test using an intracerebral (ic) challenge after a more prolonged immunization procedure. The Japanese method of using a lyophilized reference vaccine with each test was also employed. It was found that the ip and the ic test appeared to show similar relative differences between lots. The ip test was more quickly and readily performed, gave reasonably consistent results on repetition, and, when used with a suitable reference vaccine, gave promise of being an entirely suitable and reliable test. Immunization by the intramuscular route rather than by the regular ip route appeared to offer no advantage and was less consistent in responses shown. Neutralizing antibody responses of the mice in the standard procedure were very quick to appear, about 4 days after the first dose of vaccine and had a peak titer about the seventh day, the time of challenge. This titer fell quickly unless challenge occurred. The antibody was heat stable, but it was readily inactivated by 2-mercaptoethanol (2-ME). Not until the 11th or 15th day did a small amount of immunoglobulin G appear. Challenge on day 7 significantly increased titers, but this antibody was also mostly inactivated by 2-ME. Interferon did not appear to play any significant role in the protection shown by the mice. PMID- 4325024 TI - [Further study of extramammary Paget's disease, with special reference to electron microscopically discernible granular substances in Paget cells]. PMID- 4325025 TI - [Ultrastructure of glomus tumors and glomus organs]. PMID- 4325026 TI - The circumstances preceding death from asthma in young people in 1968 to 1969. PMID- 4325027 TI - Progress of asthma and adrenocortical function. PMID- 4325028 TI - Non-bacterial thrombotic endocarditis in association with mucus-secreting adenocarcinomas. PMID- 4325029 TI - Effect of near-ultraviolet light on the respiratory chain of Escherichia coli. PMID- 4325030 TI - A spin label study of the influence of cholesterol on phospholipid multibilayer structures. PMID- 4325031 TI - Properties of the angiotensin-converting enzyme of lung. PMID- 4325032 TI - Pinocytotic vesicles of the pulmonary endothelial cell. PMID- 4325033 TI - Metabolism of vasoactive polypeptides in the pulmonary circulation. PMID- 4325034 TI - Bradykinin potentiating factor. PMID- 4325035 TI - Lactic dehydrogenase (LDH) isoenzymes in cell cultures from different human tissues and organs. PMID- 4325036 TI - Induction of interferon by bacterial vaccines and allergenic extracts. PMID- 4325037 TI - Immunodiffusion studies of feline leukemia and sarcoma. PMID- 4325038 TI - A search for natural antibody against feline and murine leukemia antigen by mixed hemadsorption test. PMID- 4325039 TI - Virologic and immunologic aspects of feline viral rhinotracheitis virus. PMID- 4325040 TI - Genital infection induced by feline rhinotracheitis virus and effects on newborn kittens. PMID- 4325041 TI - Pathogenicity of feline viral rhinotracheitis virus and effect on germfree cats, growing bone, and the gravid uterus. PMID- 4325042 TI - Feline reovirus. PMID- 4325043 TI - Feline Syncytial Virus. PMID- 4325044 TI - Comments on feline syncytia-forming virus. PMID- 4325045 TI - Epizootiology of feline respiratory infections. PMID- 4325046 TI - Comments on epizootiology of feline respiratory infections. PMID- 4325047 TI - Effect of ACTH and adrenal hormones on cleft palate frequency in CD-1 mice. PMID- 4325048 TI - Serum immunoglobulins in patients with recurrent intraoral herpes simplex infections. PMID- 4325049 TI - Fine structural demonstration of hepatic glucose 6-phosphatase activity after prefixation of fresh frozen sections in glutaraldehyde. PMID- 4325050 TI - Excited states of the DNA base pairs. PMID- 4325051 TI - [Ultrastructure of mammary gland medullary epithelioma]. PMID- 4325052 TI - Papaverine-induced inhibition of phosphodiesterase activity in various mammalian tissues. PMID- 4325053 TI - The influence of cyclic 3',5' -AMP on contractile responses induced by vasopressin in isolated rat uterus. PMID- 4325054 TI - Histamine metabolism in experimental silicosis. II. In vivo experiments in guinea pigs. PMID- 4325055 TI - Gluconeogenesis and the factors that control the process in chickens. PMID- 4325056 TI - [Hypervasopressinism and hypercorticism in skull injured patients]. PMID- 4325057 TI - [The role of bacteria in experimental amebiasis]. PMID- 4325058 TI - Celebrity lecture: the scientific basis of archeological investigation. PMID- 4325059 TI - Deterioration of uredospores of wheat stem rust under natural conditions. PMID- 4325060 TI - Lyophilization of human cytomegaloviruses. PMID- 4325061 TI - [Peripheral nerve responses in guinea pigs: action potentials of the auditory nerve induced by click and tone pips (filtered clicks) of various frequencies]. PMID- 4325062 TI - [The circle of the prophet and sorcerer]. PMID- 4325064 TI - Melanoderma induced by depot-tetracosactrin. PMID- 4325063 TI - Nucleocytoplasmic interactions in the control of mitochondrial structure and function in Neurospora. PMID- 4325065 TI - [Permanent hypertension and changes in the sodium-potassium content of the aortic wall following angiotensin II infusions in rats]. PMID- 4325066 TI - [Effect of various detachment procedures on the permeability and metabolism of permanent tissue culture cells]. PMID- 4325067 TI - [Transport studies, morphological, morphometric and histochemical studies on the behavior of the intestinal mucosa in the surgically bypassed jejunal segment of rats]. PMID- 4325068 TI - [Ureteral tumors in children]. PMID- 4325069 TI - Activity of aminotransferases and phosphatases in experimental intoxication of rabbits with mercuric dichloride (HgCl2). PMID- 4325070 TI - Using corticosteroids. PMID- 4325071 TI - Determination of 3-methoxy-4-hydroxyphenylethylene glycol (MHPG) in cerebrospinal fluid. PMID- 4325072 TI - [Is adenosine cyclic 3',5' monophosphate a specific hormonal mediator?]. PMID- 4325074 TI - [Vascularization of neuroectodermal tumors of various malignancy grades]. PMID- 4325073 TI - The oxidative metabolism of Schistosoma mansoni and the effects of antischistosomal drugs and cytochrome oxidase inhibitors. PMID- 4325075 TI - Immunoglobulin M specific for measles and mumps in multiple sclerosis. AB - Sera from 43 patients with multiple sclerosis were tested by immunofluorescence. Sera from patients with active multiple sclerosis included four with measles virus-specific immunoglobulin M (measles IgM) and two with mumps virus-specific IgM (mumps IgM). In one case each mumps IgM and measles IgM seem to have persisted for two and a half years and three years respectively. In a comparable group of 43 patients with other nervous diseases measles IgM was found in only one serum, and among 43 normal patients no measles or mumps IgM was found.Herpes simplex virus-specific IgM (herpes simplex IgM) was distributed among all three groups. Anticellular IgM was also found, predominantly in active multiple sclerosis, and persisted in two sera for two and a half years. PMID- 4325076 TI - Neuropathy due to amyloid in myelomatosis. PMID- 4325077 TI - [Vaccination against a cancerous disease: Mareck's disease in poultry]. PMID- 4325078 TI - [Study on automatic analysis and quantification of the diverse states of wakefulness and sleep in the rat]. PMID- 4325079 TI - Thyroid secretion in vitro: inhibition of TSH and dibutyryl cyclic-AMP stimulated 131-I release by Li+1. PMID- 4325081 TI - Vitamin D3-induced calcium-binding protein. Binding characteristics, conformational effects, and other properties. PMID- 4325082 TI - Early changes in the synthesis of acidic nuclear proteins in human diploid fibroblasts stimulated to synthesize DNA by changing the medium. PMID- 4325080 TI - Metabolism of calcium and effect of divalent cations on respiratory activity of yeast mitochondria. PMID- 4325083 TI - Isolation and characterization of secretory vesicles in germinated pollen of Lilium longiflorum. PMID- 4325084 TI - Collagenase and periodontal diseases: a review. PMID- 4325085 TI - The nature of the ribonucleic acid synthetized in vitro by Sendai virus-induced ribonucleic acid-dependent ribonucleic acid polymerase. PMID- 4325086 TI - Beta-lactamase and the resistance of Pseudomonas aeruginosa to various penicillins and cephalosporins. PMID- 4325087 TI - Inactivation of myxoviruses by oxidized polyamines. PMID- 4325088 TI - Characterization of the abortive infection of chick embryo cells by herpesvirus type I. PMID- 4325089 TI - Parainfluenza virus surface projections: glycoproteins with haemagglutinin and neuraminidase activities. PMID- 4325090 TI - Entry of infectious bovine rhinotracheitis virus into cells. PMID- 4325091 TI - The acid-soluble components of adenovirus and of adenovirus-infected cells. PMID- 4325092 TI - [Detection and identification of cholera vibrios, with special reference to rapid diagnosis and application of kappa-type phage]. PMID- 4325093 TI - [Treatment of Japanese encephalitis with synthetic alpha 1-24 ACTH-Z]. PMID- 4325095 TI - Neurological complications of systemic cancer. PMID- 4325094 TI - Biochemical procedures in different forms of cancer. PMID- 4325097 TI - [Importance of calcium ions for positive inotropic effect of cardiac glycosides and catecholamines]. PMID- 4325096 TI - Infectious complications of neoplastic disease. PMID- 4325098 TI - Electron spin resonance studies of the solubilization of nitroxide spin probes by micellar solutions. PMID- 4325099 TI - Induction of cellular DNA synthesis in human leukocytes by Epstein-Barr virus. PMID- 4325100 TI - Herpes-like Epstein-Barr virus in leprosy. PMID- 4325101 TI - Dream recall and the bias of intellectual ability. PMID- 4325102 TI - The anatomy of domiciliary care. PMID- 4325103 TI - RNA-dependent RNA polymerase activity associated with virions and subviral particles of myxoviruses. AB - In vitro RNA synthesis is catalyzed by an enzyme found in purified virions of each of nine influenza strains tested. The extent of [(3)H]UTP incorporation observed is strain dependent, with an obligate requirement for Mn(2+) ions and RNA template. At least 30% of purified product RNA shows resistance to degradation by ribonuclease A and T1 before and after annealing with exogenous RNA from influenza virions. PMID- 4325104 TI - Vitamin D metabolism: the role of kidney tissue. AB - The appearance of a polar metabolite of 25-hydroxychotecalciferol has been studied in the intestinal mucosas of nephrectomized rats and rats which have been made uremic by ureter ligation. In confirmation of previous work by Fraser and Kodicek, it was found that nephrectomy prevents the appearance of this metabolite in the intestine. On the other hand, equivalent amounts of the metabolite were found in uremic rats and in sham-operated controls, showing that the production of this metabolite is independent of the uremic state of the animals. In addition, it was shown that the metabolite produced in vitro by kidney homogenates is identical to that found in vivo in the intestine. PMID- 4325105 TI - Adenosine 3',5'-monophosphate increases capacity for RNA synthesis in rat liver nuclei. AB - Liver nuclei isolated from rats injected with adenosine 3', 5'-monophosphate exhibit an increased capacity for RNA synthesis compared with nuclei from control animals. This effect, which is highly specific for the cyclic nucleotide. can be observed within 1 hour after injection in both unoperated and adrenalectomized rats. These findings suggest that induction of enzyme synthesis mediated by way of adenosine 3', 5'-monophosphate may be controlled, at least in part, at the level of gene transcription. PMID- 4325106 TI - Electrophysiological observations in normal and dystrophic chicken muscles. AB - Intracellular recordings were made on the fast posterior latissimus dorsi muscles of normal and dystrophic chickens. In the dystrophic chickens, the rate of rise of the action potential was decreased. With repetitive indirect stimulation, the action potentials decreased in size and disappeared; only an end-plate potential remained. Membrane resistance, membrane capacitance, and duration of miniature end-plate potentials were increased. A decrease in sodium permeability may be in part responsible for the observed alterations in the electrical properties of the nerve terminal and postsynaptic muscle membrane. PMID- 4325107 TI - Carcinoma in situ of the breast. PMID- 4325108 TI - Steps in the diagnosis of three functioning endocrine tumors. PMID- 4325109 TI - The dose rate factor from interstitial irradiation with 103-palladium and 109 palladium. PMID- 4325110 TI - [Adrenergic transmission]. PMID- 4325111 TI - [Poliomyelitis virus relatives]. PMID- 4325114 TI - Correlation between optical density and viable germ count during cultivation of B. pertussis. PMID- 4325113 TI - [Adenolymphoma of the parotid gland]. PMID- 4325115 TI - Activity of vagal respiratory motoneurons in anaphylactic shock in rabbits. PMID- 4325116 TI - Activity of pulmonary stretch receptors in anaphylactic shock in rabbits. PMID- 4325117 TI - Histochemical data on the sebaceous glands in the lips of the marmoset (Callithrix jacchus). PMID- 4325118 TI - Traumatic bitemporal hemianopsia. Survey of the literature and report of a case. PMID- 4325119 TI - The renin system in mice. Effects of removal of kidneys or (and) submaxillary glands in different strains. PMID- 4325120 TI - Heterotransplantation of human adenocarcinomas of the colon and rectum to the mouse mutant Nude. A study of nine consecutive transplantations. PMID- 4325121 TI - Mallory bodies in liver biopsies with fatty changes but no cirrhosis. A morphological, biochemical and clinical investigation. PMID- 4325122 TI - [Study of tolerance to beta-1-24 tetracosactid with corticotropic effect]. PMID- 4325124 TI - Herpesvirus and other factors related to the genesis of cervical cancer. PMID- 4325123 TI - Two-colour immunofluorescence studies on EBV-determined antigens. PMID- 4325127 TI - [Study of conformational transitions in endoplasmic reticulum membranes by means of a paramagnetic probe]. PMID- 4325125 TI - Combined drug therapy for ovarian carcinoma. PMID- 4325126 TI - [Interactions of some viruses with peritoneal macrophages]. PMID- 4325128 TI - [Structure of multinuclear non-heme centers in iron-containing proteins]. PMID- 4325129 TI - [Morphological analysis of bones excavated from crematory. Population of East Pomeranian culture centered around Gdansk]. PMID- 4325130 TI - [Effect of cortisone and ACTH on the behavior of some of the enzymes in the epithelial and glandular cells of the duodenum in white rats]. PMID- 4325131 TI - Classification and concepts of causation of mental illness in a rural Malay community. PMID- 4325132 TI - A major genetic locus affecting resistance to infection with murine leukemia viruses. I. Tissue culture studies of naturally occurring viruses. AB - Previous studies have indicated that all naturally occurring murine leukemia viruses propagate significantly more efficiently on embryo cells of either NIH Swiss or BALB/c mice. Studies of the plaquing efficiency of representative viruses on embryo cells of various inbred and hybrid mice indicate that the pattern of sensitivity of the cells is genetically determined. All of 23 strains tested were found to resemble either NIH Swiss (N-type) or BALB/c (B-type) with respect to plaquing efficiency of these viruses. Virus growth on embryo cells derived from (N-type x B-type)F(1) hybrids indicated dominance of resistance to both types of viruses. Backcross hybrid studies indicated that a single locus is the primary determinant of the host-range patterns observed. This locus has no effect on growth of certain laboratory-passaged leukemia viruses which propagate equally well on embryo cells of all mouse strains, F(1), and backcross hybrids. Though other genetic and nongenetic factors influence viral growth or expression in vitro and in vivo, the genetic locus described appears of major significance in the biology of murine leukemia. PMID- 4325133 TI - A major genetic locus affecting resistance to infection with murine leukemia viruses. II. Apparent identity to a major locus described for resistance to friend murine leukemia virus. AB - The N-B locus affecting tissue culture infectivity with naturally occurring murine leukemia viruses appears to be identical to the Fv-1 locus described for sensitivity to Friend leukemia virus. Results of tissue culture studies were parallel to results of studies in vivo and indicate that the F-S virus is N tropic and the F-B virus is NB-tropic. Inbred and partially congenic mouse strains sensitive at Fv-1 show N-type sensitivity; strains resistant at Fv-1 show B-type sensitivity. The Fv-2 locus does not appear to exert significant effect in tissue culture. Knowledge of N-B type has been useful in predicting Fv-1 sensitivity. PMID- 4325134 TI - Quantitation of Simian virus 40 sequences in African green monkey, mouse and virus-transformed cell genomes. PMID- 4325135 TI - Infective hepatitis and the handling of specimens in general practice. PMID- 4325136 TI - The hot-cold theory of disease. Implications for treatment of Puerto Rican patients. PMID- 4325137 TI - [Use of gel-containing sterilizing media for transplant storage]. PMID- 4325138 TI - Cholinergic and dopaminergic mechanisms in Huntington's chorea. PMID- 4325139 TI - [Effect of a tetracosactide with depot action in the asthmatic syndrome]. PMID- 4325141 TI - Serological identification of hamster oncornaviruses. PMID- 4325140 TI - Transformation and productive infection of human osteosarcoma cells by a feline sarcoma virus. PMID- 4325143 TI - [Polyneuropathy as an early symptom of neoplastic disease]. PMID- 4325142 TI - [Contemporary views on diabetic neuropathy]. PMID- 4325144 TI - Wilms' tumor. I. Clinical features and tumor biology. PMID- 4325145 TI - [Changes in lumph node structure after lymphography]. PMID- 4325146 TI - [Glucose-6-phosphatase activity in tuberculosis-infected animals during long-term use of bacteriostatic agents and group B vitamins]. PMID- 4325147 TI - [E.E.G. frequency is a valuable measurement of the excitability of the recorded region]. PMID- 4325148 TI - [Development of ocular movement frequency during ocular movement phase in normal humans]. PMID- 4325149 TI - [Ocular movement phase during several nights of recording with the same patient]. PMID- 4325150 TI - [Recording of 2 sleep traces in Creutzfeldt-Jakob disease]. PMID- 4325151 TI - The effect of the venom of the black widow spider Latrodectus mactans tredecimguttatus on the giant neurones of Periplaneta americana. PMID- 4325152 TI - [Acute parapsoriasis]. PMID- 4325153 TI - [Intravenous chemotherapy of pulmonary tuberculosis]. PMID- 4325154 TI - Biosynthesis, in vitro, of "histidine-protein"--a biochemical marker in epidermal differentiation. PMID- 4325155 TI - Abiological synthesis of adenosine 2'-, 3'- and 5'-monophosphates using recoiled 31P atoms obtained from the beta-decay of 31Si. PMID- 4325156 TI - Studies in the alkaline denaturation of DNA and the stability of the helix. PMID- 4325157 TI - Studies on the function of deoxyribonuclease inhibitor after partial hepatectomy. PMID- 4325158 TI - Inhibition of nuclear NAD nucleosidase and poly ADP-ribose polymerase activity from rat liver by nicotinamide and 5'-methyl nicotinamide. PMID- 4325159 TI - A study of the atypical ribosomal RNA components of Rhodopseudomonas spheroides. PMID- 4325160 TI - Documentation of syndactyly and Treacher Collins syndrome for possible concomitant speech disorders. PMID- 4325161 TI - [LINAC radiation effect on human glioma and glial cells]. PMID- 4325162 TI - [Identification and some morphologic characteristics of proadenohypophysis cells of gobies]. PMID- 4325163 TI - [Analysis of respiratory virus infections in GDR. 3d quarter, 1970]. PMID- 4325164 TI - [The ACTH test in newborns of diabetic mothers]. PMID- 4325165 TI - Growth inhibiting effects of cytotoxic agents on human tumor and tumor-bearing normal tissue in vitro. PMID- 4325166 TI - Feulgen-microspectrophotometric determination of different evolutionary patterns in serial cultures of cells derived from human skin tumours. PMID- 4325167 TI - Cytogenetic studies in Sprague-Dawley rats during the administration of a carcinogenic nitroso compound--diethylnitrosamine. PMID- 4325168 TI - "Non-specific" inhibitors in normal animal sera against polioviruses. PMID- 4325169 TI - Host-cell reactivation in mammalian cells. I. Survival of ultra-violet-irradiated herpes virus in different cell-lines. PMID- 4325170 TI - Effect of sulphhydryl dissociation on free radicals stabilized by gamma irradiated frozen aqueous solutions of cysteamine. PMID- 4325171 TI - The effect of norepinephrine and dibutyryl cyclic adenosine monophosphate on cation transport in duck erythrocytes. AB - Freshly prepared duck erythrocytes, incubated either in plasma or an isotonic synthetic medium containing norepinephrine ([K] of both media approximately 2.5 mM), maintain water and electrolyte composition in the steady state (upper steady state) for at least 90 min. If incubated in the synthetic medium without norepinephrine or in plasma to which a beta-adrenergic blocking agent (propranolol) is added, the cells lose both water and electrolyte (predominantly KCl) until a new steady state is reached (lower steady state). Reaccumulation of water and electrolyte from isotonic solutions toward the upper steady-state levels requires the addition of norepinephrine and KCl. Reaccumulation is maximal when the concentration of K and norepinephrine in the medium is 15 mM and 10( 7)M, respectively. Dibutyryl cyclic-AMP (10(-2)M) mimics norepinephrine in lower steady-state cells. Although an analogous effect in upper steady-state cells was not established with certainty, it is proposed that the catecholamine-induced net changes in water and electrolyte movement in duck erythrocytes are a consequence of stimulation of the activity of a membrane-bound adenyl cyclase system. PMID- 4325172 TI - Wave propagation in the early stages of aggregation of cellular slime molds. PMID- 4325173 TI - Chemotaxis and the early stages of aggregation in cellular slime molds. PMID- 4325174 TI - Effect of sulfonylureas on the permeability to water and electrical properties of the urinary bladder of the toad. PMID- 4325175 TI - Effect of urea derivatives and analgetics on the permeability to water and electrical properties of the urinary bladder of the toad. PMID- 4325176 TI - Modified characteristics of the aortic baroreceptor activities in the spontaneously hypertensive rat. PMID- 4325177 TI - [Chemoprophylaxis of cholera: value, expectations, and limitations]. PMID- 4325178 TI - Pulling together. PMID- 4325179 TI - Another humoral substance that enhances adrenergic responsiveness during acute renal ischaemia. PMID- 4325180 TI - Tumour immunity induced in mice with cell-free homogenates of influenza virus infected tumour cells. PMID- 4325181 TI - Wilms' tumor. 3. Special problems in therapy. PMID- 4325182 TI - Marek's disease research--history and perspectives. PMID- 4325183 TI - The effect of early natural exposure to Marek's disease on immunization of breeders by vaccination. PMID- 4325184 TI - Short-term intensive corticotrophin treatment in myasthenia gravis. PMID- 4325185 TI - A new bioassay for thyroid-stimulating hormone. PMID- 4325186 TI - Perianal Paget's disease. PMID- 4325187 TI - [Abdominal malignant tumors in children. 6 years' experience, with special reference to intestinal lymphosarcoma and renal tumors: Wilms' and neuroblastoma]. PMID- 4325188 TI - [Hypoglycemic encephalopathy. Clinical and pathogenetic considerations]. PMID- 4325189 TI - [Oral contraceptives and hypertension]. PMID- 4325190 TI - [The role of radioactive lymphography in the complex treatment of rectal cancer with lymph node metastases]. PMID- 4325191 TI - [The importance of the histologic structure of neurogenic tumors of the mediastinum in assessing the clinical manifestations and prognosis]. PMID- 4325192 TI - [The carcinogenic effect of the herbicide monuron]. PMID- 4325193 TI - [Ovarian thecomatosis and hemorrhage in menopause]. PMID- 4325194 TI - [Arrhenoblastoma of the ovary (report of 2 cases)]. PMID- 4325195 TI - [The role of the thymus in carcinogenesis]. PMID- 4325196 TI - [Clinical studies, hormone tests and methods of treatment in patients with Stein Leventhal syndrome]. PMID- 4325197 TI - [Surgery of heterotopic pancreatic tissue]. PMID- 4325198 TI - [Importance of lymphography for the selective therapy of carcinoma in gynecology]. PMID- 4325199 TI - Electron microscopy in head and neck oncology. PMID- 4325200 TI - Eosinophilic xanthomatous granulomatosis and Letterer-Siwe's disease. PMID- 4325201 TI - Malignant granular cell tumor. Histochemical and electron microscopic study. PMID- 4325202 TI - Isolation of turkey herpesvirus in cell culture. PMID- 4325203 TI - Human lymphocyte transformation with virus antigens. PMID- 4325204 TI - Neural integrations in the substrate for sleep and vigilance. PMID- 4325205 TI - On the possible role of crystals in the origins of life. V. The polymerization of glycine. PMID- 4325206 TI - [Virus induced diabetes mellitus in the white mouse]. PMID- 4325207 TI - [The mechanism of ovulation]. PMID- 4325208 TI - Cortisol binding in cultured bovine mammary cells. PMID- 4325209 TI - Potentiation of ovarian hormones by ACTH or prednisolone in maintenance of pregnancy after ovariectomy. PMID- 4325211 TI - Effect of cyclic adenosine 3',5'-monophosphate on the incorporation of 3H-leucine into polypeptides by beef thyroid polysomes in vitro. PMID- 4325210 TI - Effect of dibutyryl cyclic-AMP on adrenal catecholamine-synthesizing enzymes in repeatedly immobilized hypophysectomized rats. PMID- 4325212 TI - Ontogeny of adrenal function in fetal and neonatal rhesus monkeys: in vitro corticosteroidogenesis. PMID- 4325213 TI - Polynucleotide kinase from rat liver nuclear extracts. PMID- 4325214 TI - Hormonal and dietary control of enzymes in the rat. 3. The regulation of liver serine dehydratase and ornithine delta-aminotransferase in hypophysectomized pancreatectomized rats. PMID- 4325215 TI - Studies on cytochrome a. XIX. On the subunit structure and spin states of cytochrome oxidase from beef heart muscle. PMID- 4325217 TI - Plasma deoxycorticosterone in man. PMID- 4325216 TI - Studies on salivary gland ribonucleases. I. Purification and properties of a ribonuclease from horse submaxillary gland. PMID- 4325218 TI - Regulation of cortisol secretion in Parkinson's syndrome and narcolepsy. PMID- 4325219 TI - A case of Bartter's syndrome with surgical treatment followed for four years. PMID- 4325220 TI - Effect of prostaglandin on the secretion of human growth hormone. PMID- 4325221 TI - Portal hypertension following surgery, x-radiation, and actinomycin D therapy of nephroblastoma. PMID- 4325223 TI - Changing pattern of the antimicrobial susceptibilities of Escherichia coli in neonatal infections. PMID- 4325224 TI - Skeletal age prediction. PMID- 4325222 TI - Diabetes mellitus in childhood: a review. PMID- 4325225 TI - Malacoplakia: report of a case with observations on experimental production of the lesion. PMID- 4325226 TI - Experimental thoracic duct obstruction in dogs. PMID- 4325228 TI - Enhancement of 32P incorporation into phospho- lipids in cultured cells by sendai virus of parainfluenza type 1. PMID- 4325227 TI - Plaque formation by sendai virus of parainfluenza virus group, type 1 on monkey, calf kidney and chick embryo cell monolayers. PMID- 4325229 TI - [Arteriosclerosis--nicotinic acid therapy. 12. Some effects on experimental animals]. PMID- 4325231 TI - [A case of tympano-jugular non-chromaffin paraganglioma]. PMID- 4325230 TI - [Mammography. 3. Benign and malignant tumors of the breast]. PMID- 4325232 TI - [Etiology and epizootiology of swine dysentery]. PMID- 4325233 TI - [Clostridium intoxications in swine]. PMID- 4325234 TI - [Angiographic diagnosis of chronic pancreatitis and adenocarcinoma of the pancreas]. PMID- 4325235 TI - [Radiodiagnosis of chemodectoma of the jugular vein]. PMID- 4325236 TI - [The covalent cross-links in collagen]. PMID- 4325237 TI - Fetoglobulin. PMID- 4325238 TI - Acute circulatory failure secondary to myocardial infarction. PMID- 4325239 TI - [Drug therapy in myasthenia gravis]. PMID- 4325240 TI - [The direct immunofluorescence test in Marek's disease]. PMID- 4325241 TI - Electron microscope observations of strains of parainfluenza-3 virus isolated from cattle and sheep. PMID- 4325242 TI - [Experiments on the immunization of calves with the sheep strain of Myxovirus parainfluenzae-3]. PMID- 4325243 TI - Some peculiar fine structures in the pancreatic islets of diabetic and non diabetic rodents. PMID- 4325245 TI - Rhinoviruses: isolation from cattle with acute respiratory disease. PMID- 4325244 TI - Redox-state and adenylic system in albino rat liver during experimental ketosis. PMID- 4325246 TI - Factors affecting susceptibility of primary cultures of bovine kidney cells to infection with foot-and-mouth disease virus. PMID- 4325247 TI - Serologic evidence for adenovirus infection in California cattle. PMID- 4325249 TI - An electron paramagnetic resonance study of Aplysia myoglobin. PMID- 4325248 TI - Interaction of hemoglobin with ions. Allosteric effects of the binding of anions. PMID- 4325250 TI - Rat liver cytosol phosphoprotein: purification and enzymatic phosphorylation and dephosphorylation. PMID- 4325251 TI - Sleep in patients with Parkinson's disease and normal subjects prior to and following levodopa administration. PMID- 4325252 TI - Effect of Clostridium perfringes beta antitoxin and colostral absorption on incidence of calf scours. PMID- 4325253 TI - Bovine herpesvirus IBR-IPV. The antibody virus neutralization reaction. PMID- 4325254 TI - Hydranencephaly of calves associated with natural bluetongue virus infection. PMID- 4325255 TI - [Generalized herpes simplex in adults (virus isolation from blood)]. PMID- 4325256 TI - Lung lipids and pulmonary silicosis in rats. PMID- 4325257 TI - [Histamine, serotonin and kininogen in shock produced by intravenous injection of quartz particles in rats]. PMID- 4325258 TI - [Contribution of the echographic examination in a radiological unit]. PMID- 4325259 TI - Amebic abscess of liver following metronidazole therapy. PMID- 4325260 TI - Familial breast carcinoma. PMID- 4325261 TI - [Diagnosis of renovascular hypertension]. PMID- 4325262 TI - Salivary gland tumors. PMID- 4325263 TI - [Angiography in the diagnosis of neoplasms of the soft tissues of the extremities]. PMID- 4325264 TI - [Cutaneous amebiasis in infants]. PMID- 4325265 TI - Pelvic arteriography in trophoblastic disease. PMID- 4325266 TI - Lymphogram control during pelvic lymphadenectomy. PMID- 4325267 TI - The uptake of oestrogen by endometrial carcinoma. PMID- 4325268 TI - Respiratory distress syndrome following lymphangiography. PMID- 4325269 TI - [Liver damage following colloidal thorium dioxide. A short review and a case]. PMID- 4325270 TI - [Biochemical aspects of the pathogenesis of pulmonary emphysema]. PMID- 4325271 TI - [Calculation of body length of fetus and infants by the transverse diameter of the foramen occipitale magnum]. PMID- 4325273 TI - [Effect of steroid hormones on excretion of bile and bilirubin. 2. Effect of steroid hormones on concentration of serum bilirubin in children with jaundice]. PMID- 4325272 TI - [Effect of steroid hormones on excretion of bile and bilirubin. 1. Experimental studies on albino rats with biliary fistula]. PMID- 4325274 TI - [Diagnostic value of carcino-fetal antigens in digestive tumors]. PMID- 4325275 TI - [Mitochondrial DNA-polymerase from tumor and normal tissues]. PMID- 4325277 TI - [Difference between the collagenase-induced catabolic rate of tail and dorsal skin collagen of mice in relation to cancer induction]. PMID- 4325276 TI - [Comparative study of the acetate-2-C14 uptake into the lipids of isolated mitochondria from various normal tissues and transplantable tumors]. PMID- 4325278 TI - [Evolution of the consumption of the major antibiotics in Paris hospitals from 1959 to 1969]. PMID- 4325279 TI - Application of the electron spin resonance technique for quantitative evaluation of the resorption rate of irradiated bone grafts. PMID- 4325280 TI - Long term treatment with ACTH and allergenic properties of synthetic beta-1-24 corticotrophin. PMID- 4325281 TI - Comparison of the incidence and site ff malignancies in Taipei, Taiwan and Little Rock, Arkansas. PMID- 4325282 TI - Dissociation of the disappearance of bioactive and radioimmunoreactive ACTH from plasma in man. PMID- 4325283 TI - [Symposium on R factor]. PMID- 4325284 TI - [Possibilities and limitations of the use of Synacthen Depot Ciba in dermatology]. PMID- 4325285 TI - Communication between nerve and muscle. PMID- 4325286 TI - Trophic interaction between cloned tissue culture lines of nerve and muscle. PMID- 4325287 TI - Total structure of capreomycin IB, a tuberculostatic peptide antibiotic. PMID- 4325288 TI - [Japanese myelo-opticoneuropathy]. PMID- 4325289 TI - [Radioimmunologic method of determining protein and polypeptide hormones in blood plasma (review of the literature)]. PMID- 4325290 TI - [Blood ACTH levels in patients with Itsenko-Cushing disease and the effect of radiotherapy]. PMID- 4325291 TI - [Cocobalt-60 therapy of urinary bladder carcinoma. 5-year results]. PMID- 4325292 TI - [Current problems and principles of diagnosis and treatment of cerebral vascular accidents]. PMID- 4325293 TI - Factor X. Immunological studies. PMID- 4325294 TI - [Collagen induced 5-HT- liberation in blood platelets]. PMID- 4325295 TI - [Difficulties in the differential diagnosis of focal encephalitis and several brain tumors]. PMID- 4325296 TI - [Tumors of the cerebral hemispheres without general cerebral symptoms or with late manifestations of them]. PMID- 4325297 TI - [Correlations between plasma renin activity and blood pressure, erythrocyte count, hemoglobin, hematocrit as well as sodium, potassium, urea and creatinine in serum of hypertensive patients]. PMID- 4325298 TI - [Carcinogenic alkylating substances. IV. 1,3-propane sultone and 1,4-butane sultone]. PMID- 4325299 TI - Effects of starvation on levels of corticotrophin releasing factor, corticotrophin and plasma corticosterone in rats. PMID- 4325300 TI - The relationship between steroid production from endogenous precursors and from added radioactive precursors by rat adrenal tissue in vitro. The effect of corticotrophin. PMID- 4325301 TI - Water metabolism in the hypophysectomized Brattleboro (DI) rat. PMID- 4325302 TI - Drainage of radiographic contrast media from the abdominal cavity. Experimental studies in rats. PMID- 4325303 TI - Reported vs recorded sleep characteristics. PMID- 4325304 TI - [The adsorption of poly-2-vinylpyridine-N-oxide on quartz particles]. PMID- 4325305 TI - The function of the corneal epithelium in health and disease. The Jonas S. Friedenwald Memorial Lecture. PMID- 4325306 TI - Florenal in treatment of herpesvirus and adenovirus eye diseases. PMID- 4325307 TI - Dopamine: A retinal neurotransmitter. I. Retinal uptake, storage, and light stimulated release of H3-dopamine in vivo. PMID- 4325308 TI - Redox state of free nicotinamide-adenine nucleotides in the cytoplasm and mitochondria of alveolar macrophages. AB - Cytoplasmic free NAD(+)/NADH ratios have been calculated from lactate to pyruvate ratios, and mitochondrial NAD(+)/NADH ratios, have been calculated from beta hydroxybutyrate to acetoacetate ratios in isolated rabbit alveolar macrophages. In freshly harvested cells, assuming a pH of 7 for the two compartments, cytoplasmic NAD(+)/NADH averaged 709 +/-293 (SD), and mitochondrial NAD(+)/NADH averaged 33.2 +/-30.2, values which are significantly different. 30 min of air incubation in a relatively poorly buffered medium showed a significant reduction in calculated mitochondrial NAD(+)/NADH to 10.1 +/-4.8. 30 min of exposure of cells to a hypoxic environment (equivalent to a nonventilated, perfused alveolus) caused significant reductions of NAD(+)/NADH in both compartments. Re-exposure of hypoxic cells to air produced a change toward normal in cytoplasmic NAD(+)/NADH but did not reverse mitochondrial abnormality. Uncertainties concerning the value of cytoplasmic and mitochondrial pH under control conditions and during experimental pertubations, limit absolute interpretation of NAD(+)/NADH ratios calculated from redox pairs, but the data suggest the following: (a) separate cytoplasmic and mitochondrial compartments for NAD(+) and NADH exist in the alveolar macrophage; (b) brief periods of exposure to moderate hypoxia of the degree seen in clinical lung disease produce decreases in both cytoplasmic and mitochondrial NAD(+)/NADH; (c) the mitochondrial changes are less easily reversed than the cytoplasmic changes; (d) measurements of NAD(+)/NADH provide an early sensitive indication of biochemical abnormality; and (e) careful control of extracellular pH is required in studies involving experimental modifications of alveolar macrophage function. PMID- 4325309 TI - Stimulation of intestinal mucosal adenyl cyclase by cholera enterotoxin and prostaglandins. AB - The effects of several prostaglandins (PG) and a highly purified preparation of cholera enterotoxin (CT) on intestinal mucosal adenyl cyclase activity and the effect of CT on intestinal mucosal cyclic 3',5'-adenosine monophosphate concentration were determined in guinea pig and rabbit small intestine and were correlated with the effects of the same agents on ion transport. Adenyl cyclase activity, measured in a crude membrane fraction of the mucosa, was found at all levels of the small intestine with the highest activity per milligram protein in the duodenum. The prostaglandins, when added directly to the assay, increased adenyl cyclase activity; the greatest effect (2-fold increase) was obtained with PGE(1) (maximal effect at 0.03 mM) and PGE(2). The prostaglandins also increased short-circuit current (SCC) in isolated guinea pig ileal mucosa, with PGE(1) and PGE(2) again giving the greatest effects. The prior addition of theophylline (10 mM) reduced the subsequent SCC response to PGE(1) and vice versa. It was concluded, therefore, that the SCC response to PGE(1), like the response to theophylline, represented active Cl secretion. CT increased adenyl cyclase activity in guinea pig and rabbit ileal mucosa when preincubated with the mucosa from 1 to 2.5 hr in vitro or for 2.5 hr in vivo but not when added directly to the assay. The increments in activity caused by PGE(1) and NaF were the same in CT-treated and control mucosa. Cyclic 3',5'-AMP concentration in rabbit ileal mucosa was increased 3.5-fold after a 2 hr preincubation with CT in vitro. Phosphodiesterase activity in the crude membrane fraction of the mucosa was unaffected by either CT or PGE(1). A variety of other agents including insulin, glucagon, parathormone, thyroid-stimulating hormone, L-thyroxine, thyrocalcitonin, vasopressin, and epinephrine all failed to change adenyl cyclase activity. It is concluded that CT and certain prostaglandins produce small intestinal fluid secretion by increasing mucosal adenyl cyclase activity, thereby stimulating an active secretory process. PMID- 4325310 TI - Inhibition of antigodies binding polyinosinic-polycytidylic acid in human and mouse lupus sera by viral and synthetic ribonucleic acids. AB - The specificities of anti-RNA antibodies of diverse origin were studied by inhibition of the binding of radioative polyinosinic polycytidylic acid. The antibodies were from human patients with systemic lupus erythematosus (SLE), older NZB/NZW F(1) mice who have SLE, and young NZB/NZW F(1) mice immunized with either synthetic or viral double-stranded (ds) RNA. The inhibitors were two viral ds and two synthetic ds RNAs, ribosomal RNA and transfer RNA. The human sera were more heterogeneous than the mouse lupus sera, and had greatest specificity for reovirus RNA. The mouse lupus sera were more homogeneous and, in general, were inhibited efficiently by all four ds RNAs. Sera from mice immunized with synthetic RNA reacted poorly with viral RNA, whereas sera from mice immunized with viral RNA reacted with all four ds RNAs and resembled the lupus sera. These results suggest a role for viruses in the induction of anti-RNA antibodies, and are compatible with the concept that virus infection as well as excessive antibody responses are involved in the pathogenesis of SLE. PMID- 4325311 TI - Abnormal hormone responses of an adrenocortical cancer adenyl cyclase. AB - Properties of adenyl cyclase of normal adrenals and of a corticosterone-producing adrenal cancer of the rat have been compared. Enzyme activity was found in all particulate fractions of both tissues. The cyclase of the tumor as well as of the adrenals was stimulated by adrenocorticotropic hormone (ACTH) over similar concentration ranges. Unexpectedly, the tumor enzyme was also stimulated by epinephrine, norepinephrine, and thyroid-stimulating hormone (TSH). These hormones produced a dose-related effect over a concentration span that was comparable with that for ACTH. The tumor cyclase was not responsive to angiotensin Il, vasopressin, glucagon, insulin, growth hormone, parathyroid hormone, and thyrocalcitonin. ACTH was the only hormonal preparation that stimulated normal adrenal cyclase. These findings are compatible either with the possibility that the adenyl cyclase receptor of the tumor has undergone structural alteration with a consequent loss of specificity for ACTH or with the possibility that the tumor possesses several cyclase regulatory receptors. PMID- 4325314 TI - Take my word--patient follow-up of medical advice: a literature review. PMID- 4325315 TI - [Studies of genetic markers of poliovirus strains]. PMID- 4325312 TI - Effect of cortisone treatment on the active transport of calcium by the small intestine. AB - It is generally recognized that glucocorticoid administration may diminish calcium absorption in vivo as well as the active transport of calcium by the intestine in vitro. Recent studies by others have emphasized the possibility of an alteration in the metabolism of vitamin D to 25-hydroxycholecalciferol in accounting for the steroid effects on calcium absorption. The results obtained in the present studies fail to support this hypothesis. The present studies confirm that the administration of cortisone or other glucocorticoids to the rat interferes with the active transport of calcium by duodenal gut sacs in vitro. This abnormality is not due to an alteration in the permeability of the intestine to calcium, and it cannot be corrected by the administration of either massive doses of vitamin D(2) or modest doses of 25-hydroxycholecalciferol. Experiments concerned with the effects of cortisone on the level of the vitamin D-dependent duodenal calcium-binding protein, the amount of bioassayable vitamin D activity in the mucosa, and the distribution and metabolism of (3)H-vitamin D(3), did not provide evidence in favor of a harmone-related defect in either the localization of vitamin D or its metabolism to 25-hydroxycholecalciferol. Alterations in the transport of iron and D-galactose, not dependent on vitamin D, suggest that cortisone treatment may be responsible for more than a simple antagonism to the effects of vitamin D. The results of the present studies indicate that cortisone administration affects the cellular mechanisms mediating calcium transport in a manner that is opposite to the effects of vitamin D, but seems to be independent of any direct interaction with the parent vitamin or its metabolites. If a disorder in vitamin D metabolism is at all involved, it is at a step subsequent to 25-hydroxylation. PMID- 4325313 TI - The distribution of sodium-potassium--activated adenosine triphosphatase in medulla and cortex of the kidney. AB - The activity of sodium-potassium-activated adenosine triphosphatase (Na-K-ATPase) is considerably higher in homogenates of outer medulla than in the cortex or papilla of the kidney. The enzyme has similar kinetic characteristics in both cortex and medulla, and binds ouabain in the same proportion. The discrepancy in enzymatic activity is not paralleled by similar change in the activity of adenyl cyclase, 5'nucleotidase, glucose-6-phosphatase, or succinic dehydrogenase. Na-K ATPase is also higher in distal convoluted tubules (ventral slices) than in the proximal tubules (dorsal slices) of the kidney of Amphiuma. The high concentration of Na-K-ATPase in the red medulla of the kidney is probably related to the presence here of the thick ascending limb of the loop of Henle, and this has important implications with regard to the mechanism of sodium reabsorption by different portions of the nephron. PMID- 4325317 TI - Erythrocyte transketolase inhibition, neuropathy and uremia. PMID- 4325316 TI - Erythrocyte transketolase activity in dialyzed patients. A reversible metabolic lesion of uremia. PMID- 4325318 TI - Anomalous insulinoma. PMID- 4325319 TI - [Unusual changes of cerebrospinal fluid cells in a cerebellar tumor]. PMID- 4325320 TI - [Otorhinolaryngological findings in viral infections]. PMID- 4325321 TI - [A case of encephalopathy associated with fatty degeneration of the liver (Reye's syndrome)]. PMID- 4325322 TI - [Alveolar cell carcinoma]. PMID- 4325323 TI - [Combined therapy of primary hepatoma with mitomycin C and radiation]. PMID- 4325324 TI - [Effect of corticosteroids on gastric acid secretion in rats. Preliminary report]. PMID- 4325325 TI - Carcinoma of the gallbladder. PMID- 4325326 TI - Clinicopathologic conference. PMID- 4325327 TI - Pulmonary blastoma (embryonal sarcoma of the lung). PMID- 4325328 TI - [Tick paralysis in chickens caused by Argas (Persicargas) persicus-larvae. 3. Neurophysiological investigations]. PMID- 4325329 TI - [Identification of the ACTH secreting cells in the rat pituitary]. PMID- 4325330 TI - In vitro effects of LATS and TSH on phosphodiesterase activity in human thyroid homogenates. PMID- 4325331 TI - Fractionation of 3-8S iodocompounds of the rat thyroid. II. The presence and behaviour of a thyroidal iodide-binding peptide (TIP). PMID- 4325332 TI - Vasopressin in the diagnostic evaluation of pituitary and hypothalamic function. PMID- 4325333 TI - [Therapy of metastasizing islet cell tumor with streptozotocin]. PMID- 4325334 TI - Model experiment for inducing gastroenteritis in albino rats. PMID- 4325335 TI - Immunization experiments against fowl pox with a vaccine prepared from low pathogenicity fowl pox virus. PMID- 4325336 TI - Adenocarcinoma of the vermiform appendix. PMID- 4325337 TI - Isolation of ultraviolet light induced pyrimidine dimers from enzymic hydrolyzates of DNA. PMID- 4325338 TI - Quantitative analysis of S-adenosylmethionine and S-adenosylhomocysteine in animal tissues. PMID- 4325339 TI - [Familial biliary fibroangiomatosis with chronic jaundice]. PMID- 4325340 TI - Cellular membranes. Structure and regulation of lipid class composition species differences, changes with age, and variations in some pathological states. PMID- 4325341 TI - Electron spin resonance evaluation of pigment accumulation during asexual sporulation in Aspergillus flavus. PMID- 4325342 TI - Bovine adrenal cortical adenyl cyclase and its stimulation by adrenocorticotropic hormone and NaF. PMID- 4325343 TI - [Comparison of some in vivo effects of cyclic 3',5'-GMP and cyclic 3',5'-AMP on glucolipid metabolism in the mouse]. PMID- 4325344 TI - Zonal centrifugation in reorienting density gradients. PMID- 4325345 TI - Aspartate aminotransferase in fat tissues: changes with growth and hormones. PMID- 4325346 TI - [Structural conversions in the membranes of Micrococcus lysodeikticus]. PMID- 4325347 TI - [Breast carcinoma in males with special reference to therapeutic and prognostic viewpoints]. PMID- 4325348 TI - [Antigenicity of various influenza vaccines in man]. PMID- 4325349 TI - Carbethoxylation of polynucleotides. PMID- 4325350 TI - Subcellular distribution of sulfite cytochrome c reductase in rat liver tissue. PMID- 4325351 TI - Isolation and stoichiometry of beef pancreas tryptophanyl-tRNA synthetase complexes with tryptophan and tryptophanyladenylate. PMID- 4325352 TI - Optical rotatory dispersion and circular dichroism of cytochrome oxidase. PMID- 4325353 TI - Optical rotatory dispersion of alkali-denatured cytochrome oxidase and heme alpha polylysine complexes. PMID- 4325354 TI - Flip-flop mechanisms in enzymology. A model: the alkaline phosphatase of Escherichia coli. PMID- 4325355 TI - Isoleucyl-tRNA synthetase. A fluorescence study of the binding properties of the synthetase from Escherichia coli. PMID- 4325356 TI - The respiratory system of Azotobacter vinelandii. 1. Properties of phosphorylating respiratory membranes. PMID- 4325357 TI - The respiratory system of Azotobacter vinelandii. 2. Oxygen effects. PMID- 4325358 TI - [Radiologic examination methods for the early diagnosis and disease process evaluation in experimentally induced tumors in rats and mice]. PMID- 4325359 TI - Enzyme patterns in young and old mouse kidneys. PMID- 4325360 TI - Organ scan diagnosis of abdominal masses in children. PMID- 4325361 TI - Cushing's syndrome in an infant associated with neuroblastoma in two ectopic adrenal glands. PMID- 4325362 TI - Antibody to Epstein-Barr virus in American patients with carcinoma of the nasopharynx. PMID- 4325363 TI - [Experimental studies on intermittent use of rifampicin alone or combined with other secondary antituberculous drugs]. PMID- 4325364 TI - [Quantitative changes of coenzymes and substrates of Glycolysis in rat-Myeloma following cytostatic therapy with C 73 in various dosage]. PMID- 4325365 TI - [Value of renin determination and of the angiotensin test in the diagnosis of renovascular hypertension]. PMID- 4325366 TI - [Plaque formation by poliomyelitis virus (str. LSc 2 ab) on monolayers of AMK and Dt-6 cells]. PMID- 4325367 TI - [The hydrolytic activity of actinomycetes in soil]. PMID- 4325368 TI - Studies on hypothalamo-pituitary-adrenocortical function of patients with the syndrome of gonadal dysgenesis. PMID- 4325369 TI - [Carcinoid: problems of pathology, biochemistry and therapy]. PMID- 4325370 TI - Blood flow in the human portal vein. A cineradiographic method using particulate contrast medium. PMID- 4325371 TI - Focal angiographic changes of cerebral lymphoma with pathologic correlation. A report of two cases. PMID- 4325372 TI - The clinical and radiographic features of massive neonatal adrenal hemorrhage. PMID- 4325373 TI - [Phenomenology of different periods of sleep: psychological correlates of tonic and phasic events]. PMID- 4325374 TI - [The Epstein-Barr Virus and Infectious Mononucleosis. Findings, interpretations, and an alternative hypothesis on the direct etiology by the Epstein-Barr Virus]. PMID- 4325375 TI - [Pathology of infection with CELO virus in chickens]. PMID- 4325377 TI - Brachydactyly with absence of middle phalanges and hypoplastic nails. A new hereditary syndrome. PMID- 4325378 TI - [Biological significance of REM-sleep. Importance of rapid eye movements in causing the principally visual component of dreams]. PMID- 4325376 TI - Inhibition of N-2-fluorenyldiacetamide induced hepatic carcinogenesis in rats by chloramphenicol: a dose-related phenomenon with reduced protein binding of carcinogen. PMID- 4325379 TI - Virology of middle ear. PMID- 4325380 TI - Collagenase in the mechanism of action of cholesteatoma. PMID- 4325381 TI - Middle ear and mastoid neoplasms. PMID- 4325383 TI - [Vaginal fibroangioma and genital prolapse]. PMID- 4325382 TI - Surgical management of adrenocortical tumors with Cushing's syndrome. PMID- 4325384 TI - [Papilliferous syringocystadenoma and basal cell epithelioma on Jadassohn's sebaceous nevus]. PMID- 4325385 TI - [Dermatomyositis (2nd presentation)]. PMID- 4325386 TI - Efficacy of isoproterenol-glucagon infusion in patients with heart disease. PMID- 4325387 TI - Developmental pattern of enzyme secretion in the embryonic venom glands of Vipera palaestinae (Ophidia, Reptilia). PMID- 4325388 TI - Comparative properties of high potassium and low potassium sheep erythrocyte membrane sodium-activated adenosine triphosphatase. PMID- 4325389 TI - Studies on translocation. VII. The nonidentity of G factor and a guanosine triphosphate-dependent cyclic 3',5'-adenosine monophosphate binding component. PMID- 4325390 TI - A block in epinephrine-induced glycogenolysis in hearts from adrenalectomized rats. PMID- 4325391 TI - The carbohydrate sequence of the glycopeptide chains of human transferrin. PMID- 4325392 TI - Carbohydrate metabolism in rats fed carbohydrate-free diets. PMID- 4325394 TI - Induction of a specific enzyme inadequacy in infant rats by the use of a homologue of riboflavin. PMID- 4325393 TI - Gluconeogenic and lipogenic enzyme activities in growing chicks fed high fat and high carbohydrate diets. PMID- 4325395 TI - Virus antibody titers in multiple sclerosis patients, siblings, and controls. PMID- 4325396 TI - [Concept of viral infections--from cell level to individual host level]. PMID- 4325397 TI - [Diagnosis of virus diseases]. PMID- 4325398 TI - [Mononucleosis caused by cytomegalovirus]. PMID- 4325399 TI - [Systemic lupus erythematosus (SLE) and persistent myxovirus infections]. PMID- 4325400 TI - [Acute hemorrhagic cystitis by adenovirus type 11]. PMID- 4325401 TI - [Acute intussusception in infancy]. PMID- 4325402 TI - [Nonspecific acute exanthematous diseases and virus infection]. PMID- 4325403 TI - [EB virus and diseases]. PMID- 4325404 TI - [Human cancer and virus--from the standpoint of virology]. PMID- 4325405 TI - [Human cancer and virus--from the standpoint of epidemiology]. PMID- 4325406 TI - [CCausative factor of coryza--with special reference to rhinovirus and coronaviruses]. PMID- 4325408 TI - [Crystallization of alpha-1-fetoprotein from plasma of a patient with primary liver cell carcinoma]. PMID- 4325407 TI - [PH determination in the brain and two-fold approach in the multiple-step cancer therapy concept. Possibilities of including the brain in the therapeutically tangible area of the body in multiple-step cancer therapy]. PMID- 4325409 TI - Influence of adrenergic receptor stimulation on glucose metabolism during starvation in man: effects on circulating levels of insulin growth hormone and free fatty acids. PMID- 4325410 TI - Studies of plasma levels and urinary excretion after intramuscular injection of triamcinolone acetonide. PMID- 4325412 TI - [Hysterosalpinography. Use of iodolipol-ether mixture as contrast medium]. PMID- 4325411 TI - [Role of adrenals in bronchial asthma in children. Effect of ACTH on 24-hour urinary excretion of 17-KS and 11-OH, peripheral blood eosinophilia and the uric acid-creatinine index in urine]. PMID- 4325413 TI - Ascites seven years after treatment of squamous cell cancer of the cervix. PMID- 4325414 TI - Ultrastructure of the neurogenic heart of Limulus polyphemus. PMID- 4325415 TI - Electron microscopic study of the in vivo erythrophagocytosis by alveolar macrophages of the cat. II. Late period: digestion. PMID- 4325416 TI - [Technics of demonstration of IgM type antibodies in congenital infections]. PMID- 4325417 TI - [Bacterial multi-resistence and therapeutic possibilities based on laboratory results]. PMID- 4325418 TI - [Pathological anatomy of malignant tumors in childhood]. PMID- 4325419 TI - Different properties of glucose-6-phosphatase and related enzymes in rough and smooth endoplasmic reticular membranes. PMID- 4325420 TI - Characterization of microvesicles produced by shearing of human erythrocyte membranes. PMID- 4325421 TI - Resolution of fragments of plasma and sarcotubular membranes in heart muscle microsomes. PMID- 4325422 TI - Immunochemical studies of detergent-soluble nucleoside phosphatases in rat liver plasma membranes. PMID- 4325423 TI - Lipid monolayers. Interactions with staphylococcal alpha-toxin. PMID- 4325424 TI - The preparation and properties of an isolated plant membrane fraction enriched in (Na plus-K plus)-stimulated ATPase. PMID- 4325426 TI - Oestrogens in oophorectomized women. PMID- 4325427 TI - Para-influenza virus infection in respiratory illnesses of infants and children. PMID- 4325425 TI - A neuron model with spatially distributed synaptic input. AB - I have assembled a neuron model simulating contiguous patches of nerve cell membrane. With this model I have examined the functional significance of different spatial and temporal distributions of synaptic inputs. The model consists of two terminal electronic analogue circuits with inputs controlled by a LINC computer. One terminal represents the inside of a membrane patch, the other represents the outside. Two circuit designs are used: one simulates spike generating regions of the neuron, the other simulates subthreshold activity in inexcitable regions. To simulate a neuron, patches are assembled in various spatial arrangements by suitable connection to the "intracellular" nodes. Thus the relation of neuron geometry to aspects of spatiotemporal summation of synaptic inputs can be investigated readily. Performance of the model is assessed by comparison with results from microelectrode studies in the cochlear nucleus of the cat. In particular, the peristimulus time (PST) histogram and averaged membrane potential are used for quantitative comparison. The model suggests that the geometry of the neuron's receptive surface can account for a wide variety of physiologically observed behavior, particularly in response to dynamic stimuli. PMID- 4325428 TI - Enzymic formation of esters of methyl sterol precursors of cholesterol. AB - For investigation of the reactions of cholesterol biosynthesis, a number of workers use the 10,000 g supernatant fraction (or similar preparations) obtained from cell-free homogenates of rat liver. We have found that esters of methyl sterol biosynthetic intermediates are formed by this crude source of enzymes. Esters of C(30)-, C(29)-, C(28)-, and C(27)-sterol intermediates have been isolated by silicic acid chromatography of an acetone extract of incubation mixtures. Competition between ester formation and demethylation of the C(28) sterol intermediate has been demonstrated. With 4alpha-methyl-5alpha-cholest-7-en 3beta-ol as substrate, maximal velocities of ester formation (0.36 nmole/30 min per mg of protein) were almost equivalent to maximal velocities of demethylation (0.45 nmole/30 min per mg of protein). Ester formation may be eliminated by carrying out incubations with microsomal preparations; ester formation may be restored completely upon addition (to the microsomes) of either coenzyme A and ATP or the supernatant fraction resulting from centrifugation at 105,000 g. Ester formation has been examined similarly with broken-cell preparations of rat skin. With $$Word$$ as substrate, the rate of ester formation was more than six times the rate of methyl sterol demethylation. The very significant competition between esterification and demethylation of methyl sterol intermediates of skin suggests that sterol intermediates accumulate in rat skin because of the rapid formation of esters that may not be further metabolized. PMID- 4325429 TI - Cholesterol biosynthesis in transplantable hepatomas: evidence for impairment of uptake and storage of dietary cholesterol. AB - Cholesterol feeding inhibits cholesterol biosynthesis in normal but not in malignant liver tissue. It has been postulated that hepatomas have suffered a specific intracellular deletion of the cholesterol feedback control mechanism, but there is little direct evidence to support this hypothesis. Rats bearing Morris transplantable hepatomas were fed high cholesterol diets for periods of up to 21 days. Cholesterol biosynthesis, as expected, was suppressed in the normal liver but not in hepatomas. The livers accumulated large amounts of cholesteryl ester but the hepatomas showed little or no increase in ester content. Cholesterol-1alpha-(3)H was administered intragastrically to other tumor-bearing rats. Uptake of radioactivity by the tumors was much slower than by normal liver. Comparison of the specific activities of liver and tumor cholesterol with that of the plasma suggested that the liver took up dietary cholesterol selectively from the blood, while the appearance of radioactivity in the tumors could be explained by slow equilibration with plasma cholesterol. Our results suggest that the insensitivity of cholesterol biosynthesis to dietary cholesterol in hepatomas could be explained by an impairment in the uptake and storage of dietary cholesterol and that the concept of an intracellular deletion of the feedback mechanism requires further evidence. PMID- 4325430 TI - Composition of lipid foams from swim bladders of two deep ocean fish species. AB - Lipid-containing deposits within the swim bladders of Coryphaenoides acrolepis and Antimora rostrata were investigated. Lipid analysis of this material, which was quite uniform from the two species, yielded the following data: neutral lipids, 36.0-41.7%; phospholipids, 53.6-56.7%; and glycolipids, 4.3-8.9%. Cholesterol (mainly in the free form) constituted 60.4%-77.8% of the neutral lipids. Sphingomyelin and phosphatidylcholine were the principal phospholipids, with sphingomyelin highest in the material from C. acrolepis and phosphatidylcholine predominant in that from A. rostrata. The overall pattern of lipids shows a resemblance to that of plasma membrane, particularly in the relatively high levels of free cholesterol, sphingomyelin, and phosphatidylserine. The lipid-to-protein ratio of the material is approximately 1.5-2 to 1. The lipids of the fine inner lining (tunica interna) of the swim bladder from a shallow water fish, the kelp bass (Paralabrax clathratus), had essentially the same composition as the much more abundant swim bladder material from the deep ocean fishes. PMID- 4325431 TI - The effect of 0 degrees C and 2,4-DNP on the uptake of micellar fatty acid, on the extraction of absorbed lipid during electron microscopy processing, and on the ultrastructure of everted jejunum. PMID- 4325432 TI - Adenosine 3',5'-monophosphate and mania. PMID- 4325433 TI - [Comparative study of the adrenocorticotrophic action of the synthetic polypeptides Humacthid-28 and Synacthen in man]. PMID- 4325434 TI - [Cell membrane--with special reference to current research on carbohydrates]. PMID- 4325435 TI - [Spontaneous acute hemoperitoneum caused by rupture of a primary carcinoma of the liver]. PMID- 4325436 TI - [Major right hepatectomy with temporary clamping of the inferior vena cava below and above the liver]. PMID- 4325437 TI - Cancer of the body and tail of the pancreas. PMID- 4325438 TI - [Case of alveolar pulmonary carcinoma with a fulminating course]. PMID- 4325439 TI - [Primary hepatic cancer coexistent with hypoglycemia]. PMID- 4325440 TI - [Isolation, analysis and radioactive labeling of nucleic acids from rat tumors induced by polyoma virus]. PMID- 4325441 TI - [Combination of short time incubation and long time culture in testing human tumor cells with cytostatics]. PMID- 4325442 TI - [Pyrrole pigments of organs during 2-amino-N-acetylfluorene-induced carcinogenesis in rats]. PMID- 4325443 TI - [Mast cells in the 7,12-dimethylbenzanthracene-induced mammary gland tumors in rats]. PMID- 4325444 TI - Demyelination and remyelination in recurrent idiopathic polyneuropathy. An electron microscope study. PMID- 4325445 TI - Histopathology and electron microscopy of three cases of subacute sclerosing panencephalitis (SSPE). PMID- 4325447 TI - [78 primary excavatio bronchial cancers]. PMID- 4325446 TI - Alterations of astrocytic organelles in various lipidoses and allied diseases. PMID- 4325448 TI - [Clinical considerations and hemodynamic studies in some cases of dynamic hypertrophic stenosis of the left ventricle]. PMID- 4325449 TI - [On hemodynamic control of renal function]. PMID- 4325450 TI - Effects of ranatensin, a polypeptide from frog skin, on isolated smooth muscle. AB - 1. The actions of bretylium tosylate on neuromuscular transmission in the rat phrenic nerve diaphragm preparation have been investigated by electro-2. On the guinea-pig ileum, threshold doses elicit repeated maximal spike contractions which are blocked by atropine. In the presence of atropine, higher concentrations of ranatensin elicit small contraction spikes superimposed on a relatively weak sustained contraction. These latter two actions are not blocked by increasing the concentration of atropine.3. Other smooth muscle preparations respond as follows: rat uterus, rhythmic contractions; rat duodenum, relaxation; rabbit aortic strip, contraction. Atropine has no effect on the above responses. The rat aortic strip does not respond to ranatensin. Ranatensin is four times as active as bradykinin on the rat uterus.4. Ranatensin can be readily distinguished from other known peptides such as angiotensin, bradykinin and the eledoisin-like peptides, by bioassay. PMID- 4325451 TI - Effects of angiotensin and noradrenaline on discharge in fibres of the cervical sympathetic nerve in cats and dogs. AB - 1. The effects of angiotensin and noradrenaline on discharge frequency in single and few-fibre preparations of the cervical sympathetic nerve of cats and dogs have been compared.2. When equal changes in blood pressure were produced by intravenous infusion of these drugs, the changes found in sympathetic discharge were similar both in anaesthetized animals and in a decerebrate one.3. Angiotensin and noradrenaline also have similar effects on discharge in sympathetic nerve fibres following complete denervation of the baroreceptor and chemoreceptor nerves.4. It is concluded that when the blood pressure is raised to 200 mmHg by angiotensin, the drug has no central stimulant action on the sympathetic nervous system. PMID- 4325452 TI - Burkitt's lymphoma: a time-space cluster of cases in Bwamba County of Uganda. AB - Seven cases of Burkitt's lymphoma have to date (March 1971) been diagnosed in the county of Bwamba in Uganda. All these patients had the clinical onset of their tumour in the 27 months from October 1966 to December 1968; five of them in the last six months of this period. Two of the patients were full sibs living in the same house. This is the most discrete time-space cluster of the disease yet recorded and provides further evidence for a role in the aetiology of Burkitt's lymphoma of an infective agent with a relatively short latent period. PMID- 4325453 TI - Somato-sympathetic reflexes during natural sleep and wakefulness in unrestrained cats. PMID- 4325454 TI - [Spontaneous activity of subcortical structure cell populations during sleep and dreaming in man]. PMID- 4325455 TI - [EEG and behavioral arousal thresholds in different sleep stages]. PMID- 4325456 TI - [Electric activity of associative cortical neurons of kittens in various sleep stages]. PMID- 4325457 TI - [Some neurophysiological aspects of natural sleep stages and arousal from spectral and correlation analyses of bioelectric activity]. PMID- 4325458 TI - [Changes in the postsynaptic potential and impulse activity of visual cortex neurons during light stimulation of varying intensity]. PMID- 4325459 TI - [Radioimmunoassay of ACTH]. PMID- 4325460 TI - [Hypophyseotropic hypothalamus hormones]. PMID- 4325461 TI - Variations in mucosal water and sodium transfer associated with the rat oestrous cycle. AB - 1. Mucosal water and sodium transfer were measured in everted sacs of rat jejunum.2. Mucosal water transfer was higher at pro-oestrus and oestrus than at metoestrus and dioestrus.3. Injection of 10 mug aldosterone I.P. 28 hr before the experiment produced a stimulation of mucosal water and sodium transfer in sacs prepared from rats at dioestrus but not in sacs from rats at oestrus.4. A significant increase in mucosal water and sodium transfer was observed when sacs from dioestrous rats were incubated with angiotensin at a concentration of 10(-9) g/ml. No effect was obtained in sacs from oestrous rats.5. Treatment of adrenalectomized-ovariectomized rats with oestradiol caused a stimulation of mucosal water transfer 28 hr after injection.6. It is suggested that the actions of ovarian steroids on water and electrolyte metabolism might be due to increased activity of both the adrenal cortex and the renin-angiotensin system. PMID- 4325462 TI - The effect on drinking of peptide precursors and of shorter chain peptide fragments of angiotensin II injected into the rat's diencephalon. AB - 1. Recently it has been shown that injection of angiotensin II into the anterior diencephalon causes the rat to drink water. In the present experiments the dipsogenic action of a number of other substances including substances related to angiotensin was tested.2. Injection of 0.001 Goldblatt u. renin into the angiotensin-sensitive region causes the water-replete rat to drink. Drinking is slower in onset and continues for longer than after injection of angiotensin II.3. Synthetic tetradecapeptide renin substrate and angiotensin I were as effective as angiotensin II at causing water-replete rats to drink.4. beta aspartic acid(1)-valine(5)-angiotensin II was also fully effective; but the D arginine substituted octapeptide was much less effective.5. The (2-8) heptapeptide retained about 50% of the dipsogenic activity of the octapeptide, whereas the absence of phenylalanine at the other end of the peptide chain in the (1-7) heptapeptide results in an inactive compound.6. The (3-8) hexapeptide and the (4-8) pentapeptide, both of which have phenylalanine at the end of the chain, and the (1-4) and (5-8) tetrapeptide fragments of angiotensin II showed only a slight action on intake of water.7. Kallikrein, bradykinin, adenosine-3'5-cyclic phosphate, vasopressin and oxytocin caused no drinking when injected into the angiotensin-sensitive region.8. It is concluded that the requirements for the dipsogenic activity of angiotensin are the same as those for its other biological actions with the qualification that the precursor peptides are also active, presumably because they give rise to angiotensin II locally. PMID- 4325463 TI - The role of the kidney in maintaining blood pressure in the adrenalectomized rat. PMID- 4325464 TI - Growth and development of sympathetic ganglion: maturation of transmitter enzymes and synapse formation in the mouse superior cervical ganglion. PMID- 4325465 TI - The effect of angiotensin on cation transport by rat kidney cortex slices. AB - 1. A study has been made of the effect of angiotensin (10(-12) g/ml.) on active and passive transport of sodium, potassium and water between rat kidney cortex slices and the incubation medium.2. Angiotensin has no effect on the passive uptake of sodium and loss of potassium by slices incubated under conditions which inhibit active transport.3. Active sodium extrusion by slices incubated under aerobic conditions is stimulated, whereas active potassium uptake is inhibited by angiotensin.4. Sodium pump activity is stimulated by angiotensin in the presence of ouabain or in the absence of potassium in the incubation medium, conditions which block the sodium for potassium exchange pump.5. There is a 2 min latent period following the application of angiotensin before a response is observed.6. These findings are discussed in relation to the mechanism of action of angiotensin on kidney sodium and fluid transport processes. PMID- 4325466 TI - Changes in renal function associated with the development of resistance of the renal vasculature to the arterial infusion of angiotensin. PMID- 4325467 TI - The importance of centrifugal force in determining semen characteristics. PMID- 4325468 TI - Transformation of malignant growth. PMID- 4325469 TI - [Intravital staining of HEp-2 cells in the course of RS virus infection]. PMID- 4325470 TI - [Morphological and cytological assay of Cercopithecus monkey kidney cells infected with cold and hot mutants of ECHO 9(Hill) virus]. PMID- 4325471 TI - Effect of antilymphocytic serum on circulating interferon in mice as a function of the inducer. PMID- 4325472 TI - [Mixed tumors of the parotid gland]. PMID- 4325473 TI - [2 cases of glomus tumor]. PMID- 4325474 TI - [ACTH in the treatment of thymus hyperplasia in the infant]. PMID- 4325475 TI - [Synthetic corticotropin in the treatment of nephrosis in childhood]. PMID- 4325476 TI - [Total proteins and blood protein electrophoretic fractions and blood glycoproteins in nephrotic children (cellulose acetate gel radial electrophoresis]. PMID- 4325477 TI - [Effect of ACTH on cytoplasmic RNA of lymphocytes]. PMID- 4325478 TI - [Current concepts on surgical treatment of carotid body tumors with a report on 4 personal cases]. PMID- 4325479 TI - [Ribonucleoprotein particles in cytoplasmic extracts of animal cells]. PMID- 4325480 TI - Tendril and glomerular collaterals of climbing fibers in the granular layer of the rat's cerebellar cortex. PMID- 4325481 TI - The synapse en marron between golgi II neurons and mossy fibers in the rat's cerebellar cortex. PMID- 4325483 TI - Virus assisted fusion of embryonic cells. PMID- 4325482 TI - Enrichment culture techniques for selection of cell culture strains with desirable physiological and genetic properties. PMID- 4325484 TI - Application of peroxidase-labelled antibodies to the intracellular localization of hormones. PMID- 4325485 TI - In vitro assays of adenyl cyclase. PMID- 4325487 TI - Ultrastructural criteria for assessing the functional integrity of endocrine cells in vitro. PMID- 4325486 TI - Methods for metabolic studies on isolated granulosa and theca cells. PMID- 4325488 TI - [Hypertension in Wilms' tumors]. PMID- 4325489 TI - [New data on vitamin D metabolism]. PMID- 4325491 TI - Restoration of glucagon responsiveness of solubilized myocardial adenyl cyclase by phosphatidylserine. PMID- 4325490 TI - Mesenteric microcirculation in rats with experimental hypertension. PMID- 4325492 TI - Inactivation of microsomal glucose-6-phosphatase by pyridoxal-5'-phosphate. PMID- 4325493 TI - DNA synthesis by an insoluble chromatin fraction associated with the nuclear membrane of animal cells. PMID- 4325494 TI - Cyclic 3';5' adenosine monophosphate-phosphodiesterase and the release of catabolite repression of beta-galactosidase by exogenous cyclic 3';5' adenosine monophosphate in Escherichia coli. PMID- 4325495 TI - Effect of indole-3-acetic acid on the synthesis of cyclic 3'-5' adenosine phosphate by Bengal gram seeds. PMID- 4325496 TI - Salt-dependent conformational changes in the cell membrane of Halobacterium salinarium. PMID- 4325497 TI - [Dysplastic and premalignant changes in the vulva. Histological and histochemical observations]. PMID- 4325498 TI - [Further experimental results in antibacterial irrigation drainage]. PMID- 4325499 TI - [Angiography in the field of vascular surgery]. PMID- 4325500 TI - [Distribution, morphology and behavior of epithelial salivary gland neoplasms]. PMID- 4325501 TI - [In vitro studies of lipid metabolism in the stimulated rat adrenal gland. 5]. PMID- 4325502 TI - [Detection of a new methylated albumin-diatomite fraction of newly synthesized DNA from mammalian cells]. PMID- 4325503 TI - [Studies on the characterization of newly synthesized DNA fractions from mammalian cells elutable from methylated albumin-diatomite columns by NaCl]. PMID- 4325504 TI - The plight of schizophrenics in modern treatment programs. PMID- 4325505 TI - Alumni group therapy for chronic schizophrenic outpatients. PMID- 4325506 TI - Primary sclerosing cholangitis. A case report. PMID- 4325507 TI - Malignant tumor of the nasopharynx. Review of literature, and observation of 100 cases (1942-1965). PMID- 4325508 TI - Tracheal obstruction with a difficult anaesthetic problem. PMID- 4325509 TI - A study on hypertension. Effect of electrolytes on the catecholamine secretion from the adrenal gland by synthetic angiotensin. II. PMID- 4325510 TI - [A meningitis epidemic caused by enterovirus in the summer of 1967 in Halle]. PMID- 4325511 TI - Activation of central sympathetic neurons by angiotensin II. PMID- 4325512 TI - [Characteristics of the lytic action of some polypeptide antibiotics on the protoplasts (spheroplasts) of bacteria]. PMID- 4325513 TI - [Effect of amino acids on growth of a synchronized culture of Bacillus polymyxa and biosynthesis of polymyxin M]. PMID- 4325514 TI - [Indication range of salivary gland scintigraphy]. PMID- 4325515 TI - [Pathogenesis of virus infection in the ENT region. A contribution on the problem of focal infection]. PMID- 4325516 TI - SV40 neutralizing antibodies in sera of US residents without history of polio immunization. PMID- 4325517 TI - Neonatal thymectomy and non-viral mammary tumours in mice. PMID- 4325518 TI - An electron microscopic study of human acute hepatitis. PMID- 4325520 TI - Cell-surface changes after infection with oncogenic viruses: requirement for synthesis of host DNA. AB - The change in the surface structure of cultutred mammalian cells infected with oncogenic DNA viruses was similar to that described for the fully and permanently transformed cell surfaces. The course of appearance of this change was established. Synthesis of host DNA is required for expression of the surface change triggered by infection with the oncogenic virus. PMID- 4325519 TI - Two decades of research on the biosynthesis of saccharides. PMID- 4325521 TI - Heterogeneity of murine leukemia virus in vitro DNA; detection of viral DNA in mammalian cells. AB - Kinetic analysis of the reassociation of DNA synthesized in vitro by a murine leukemia virus DNA polymerase revealed two classes of double-stranded product representative of 25 and 100 percent of viral genetic information. The DNA product representing the smaller portion of the viral genome comprised 85 percent of the double-stranded DNA generated in vitro and was extensively duplicated in the genomes of both normal cells and cells containing RNA tumor virus. PMID- 4325522 TI - [New data on benign cutaneous melanomas]. PMID- 4325523 TI - [Thermographic semeiology in vascular diseases of the upper limbs]. PMID- 4325524 TI - [Value of the sweat function test in hospital practice]. PMID- 4325525 TI - [Paramedullary angioma with cervical spinal cord compression]. PMID- 4325526 TI - [Bilio-digestive fistula. Apropos of 3 cases]. PMID- 4325527 TI - [Gonadectomy in congenital sex differentiation disorders]. PMID- 4325528 TI - [Characteristics of new radioisotope methods of studying the salivary glands]. PMID- 4325529 TI - [The popliteal pterygium syndrome. A dominant autosomal malformation syndrome]. PMID- 4325530 TI - Carcinoma of the colon and rectum in patients up to 25 years of age. PMID- 4325531 TI - [Ultrastructural data concerning the origin of Paget cells of the nipple]. PMID- 4325532 TI - Multiple glomus tumors of the skin. PMID- 4325533 TI - Multiple granular cell schwannomas. PMID- 4325534 TI - Prognostic significance of tumor margins in mammary carcinoma. PMID- 4325535 TI - The causal factors and function of 'yawning' in Microspathodon chrysurus (Pisces: Pomacentridae). PMID- 4325536 TI - [CELO virus infection in turkeys]. PMID- 4325537 TI - Effects of amylobarbitone and nitrazepam on the electrodermogram and other features of sleep. PMID- 4325538 TI - [On the radiotherapeutic possibilities in medullary neoplasms in relation to the tolerance of the nerve tissue]. PMID- 4325539 TI - [Lymphangio-hemangiomas in childhood and their effect on the dentition]. PMID- 4325540 TI - [Serious form of Schultz' agranulocytosis in a 3-year-old child]. PMID- 4325541 TI - [The intradermal vaccinia test is specific]. PMID- 4325542 TI - Kinetics of RNA synthesis by vesicular stomatitis virus particles. PMID- 4325543 TI - Studies on the bacteriophage MS2. IX. The heptanucleotide sequences present in the pancreatic ribonuclease digest of the viral RNA. PMID- 4325544 TI - Circadian rhythm of rat liver and lung collagenase activity. PMID- 4325545 TI - Inhibitory effect of human seminal plasma on the oxygen consumption of mitochondria. PMID- 4325546 TI - Platelet lipids: effects of a high fat or a high carbohydrate diet in pig plasma and platelet fatty acid composition. PMID- 4325547 TI - Effects of thyrotropin, prostaglandin E1 and a prostaglandin antagonist on iodide trapping in isolated thyroid cells. PMID- 4325548 TI - [Burkitt's lymphoma]. PMID- 4325549 TI - [Infectious mononucleosis]. PMID- 4325550 TI - [Retroperitoneal clostridium-perfringens-abscess]. PMID- 4325551 TI - Distribution of equine infectious anemia virus in horses infected with the virus. PMID- 4325552 TI - [Light and electron microscope study of splenic changes in Wistar rats subjected to prolonged treatment with low doses of ACTH]. PMID- 4325554 TI - [What is the value of ACTH in the prevention and treatment of post-glucocorticoid adrenal deficiency?]. PMID- 4325555 TI - [Hydrocyanic poisoning following severe burns by fused sodium cyanate. 3 cases treated with EDTACO2]. PMID- 4325553 TI - Localisation of receptors that initiate reflex vascular responses to vasoactive substances. PMID- 4325556 TI - [On the use of polymyxine B in bladder wash-outs]. PMID- 4325557 TI - Hormonal influences on fear-motivated responses. PMID- 4325558 TI - [Hyperthyroidism and periodic paralysis]. PMID- 4325559 TI - [3 amebic abscesses of the liver of pseudopleuretic form. Recovery after metronidazole without drainage or hepatotomy]. PMID- 4325560 TI - [Shelley's test. Analysis of an experience of 1500 tests]. PMID- 4325561 TI - [Participation of vitamins in the synthesis of hormones]. PMID- 4325562 TI - [Dietetics of anuria]. PMID- 4325563 TI - [Routine autopsies in hospitals. Survey on 3,000 patients deceased in a general medicine department]. PMID- 4325564 TI - [Morbidity survey of deceased patients. Classification of pathological processes]. PMID- 4325565 TI - [An unusual complication of atherosclerosis: spinal cord softening]. PMID- 4325566 TI - [Spinal cord metastases simulating a paraneoplastic neurological syndrome during an undiagnosed small cell bronchial cancer]. PMID- 4325567 TI - [Myocardial abscess during a probable staphylococcal septicemia in a cirrhotic]. PMID- 4325568 TI - [Amyloid tumors]. PMID- 4325569 TI - [Visceral calcinosis during secondary bone cancers of osteolytic form]. PMID- 4325570 TI - [Cancer and tuberculosis closely associated on the respiratory tract]. PMID- 4325572 TI - [Endocarditis due to Candida on mitral stenosis]. PMID- 4325571 TI - [Unusual varieties of bronchopulmonary tumors: primary alveolar carcinoma and bronchial cylindroma]. PMID- 4325573 TI - [Rupture of a pseudoaneurysm on an aortic prosthesis]. PMID- 4325574 TI - [Cytological diagnosis of liver cancers after laparoscopy: histological control]. PMID- 4325575 TI - [Esophageal leiomyosarcoma]. PMID- 4325576 TI - [Epidermoid carcinoma of the stomach]. PMID- 4325577 TI - [Malignant villous tumors of the stomach]. PMID- 4325578 TI - [Degenerated gastric polyposis]. PMID- 4325579 TI - [Diffuse angiomatosis of the small intestine]. PMID- 4325580 TI - [Leiomyosarcoma of the small intestine revealed by mesenteric arteriography]. PMID- 4325581 TI - [Degenerated villous tumor of the colon complicated by amyloidosis]. PMID- 4325582 TI - [Digestive localizations of Hodgkin's disease]. PMID- 4325583 TI - [Digestive localizations of myeloid leukosis]. PMID- 4325584 TI - [Malignant hemopathies complicated by mycoses]. PMID- 4325585 TI - [Bowen disease and epidermoid carcinoma of the stomach]. PMID- 4325586 TI - [Scleroderma and cancer of the stomach]. PMID- 4325587 TI - Biochemical changes of the lipid in biopsied livers of patients with malignant neoplastic diseases. PMID- 4325588 TI - Measurement of plasma angiotensin II by radioimmunoassay. PMID- 4325589 TI - [Conservative therapy of chronic kidney failure]. PMID- 4325590 TI - Spontaneous nephroblastomas in the rat. PMID- 4325591 TI - Comparative ultrastructural study on Merkel cells and dermal basal cells in poultry (Gallus domesticus). PMID- 4325592 TI - Neurosecretory endings associated with striated muscles in three insects (Schistocerca, Carausius, and Phormia) and a frog (Rana). PMID- 4325593 TI - [Histophysiological studies on the postembryonic development and the annual cycle of Formica (Hymenoptera). II. Histochemical and ultrastructural characteristics of the midgut of F. polyctena Foerst]. PMID- 4325594 TI - The incidence and trends of Parainfluenza 3, bovine viral diarrhoea, and Pasteurella haemolytica antibody titers in the serum of young cattle in the Netherlands. PMID- 4325595 TI - Interrelationships between maternal and fetal pituitary-adrenal axis. PMID- 4325596 TI - How to use cancer chemotherapy. PMID- 4325597 TI - Recognizing dwarfs at birth. PMID- 4325598 TI - Resolution of chronic eosinophilic pneumonia with corticoid therapy. Demonstration by needle biopsy. PMID- 4325599 TI - [Brain localization of generalized cytomegalic inclusion disease in newborn infants]. PMID- 4325600 TI - Sequential chemical modifications of tyrosyl residues in alkaline phosphatase of Escherichia coli. PMID- 4325601 TI - Distribution of deoxyribonucleic acid sequences in fractionated chromatin. PMID- 4325602 TI - Concerted reduction of yeast uridine diphosphate galactose 4-epimerase. PMID- 4325603 TI - A requirement for three protein components in microsomal stearyl coenzyme A desaturation. PMID- 4325604 TI - Dimerization of alpha-chymotrypsin. II. Ionic strength and temperature dependence. PMID- 4325605 TI - Isolation and characterization of a collagen from chick cartilage containing three identical alpha chains. PMID- 4325606 TI - Prostaglandin E1 and noradrenaline at the neuromuscular junction. AB - The effects of prostaglandin E(1) (PGE(1)) on neuromuscular transmission in the frog nerve-sartorius muscle preparation were studied with intracellular recording techniques. PGE(1) was inactive in all concentrations examined; both spontaneous miniature end-plate potentials and evoked end-plate potentials were unchanged after preparations were bathed in up to 2.2x10(-5)M (8 mug/ml) PGE(1). PGE(1) did not prevent the increase in end-plate potential amplitude which frequently occurred on addition of noradrenaline to the bathing solution. PMID- 4325607 TI - Induction of hypovolaemia by thirst-inducing doses of renin or angiotensin II. AB - 1. Intravenous injection of five Goldblatt units (Gbl.U) of renin, or intravenous infusion of 2.5 mug of angiotensin into nephrectomized rats decreased plasma volume by 22 +/- 2% (calculated from the increase of the haematocrit) or by 14 +/ 2% (calculated from the increase in protein concentration) within 2 minutes. Fifteen minutes and 60 min after injection or infusion, the plasma volume (calculated from both parameters) was still 10% lower than initially.2. The initial discrepancy between haematocrit values and plasma protein concentration was neither due to mobilization of red blood cells (r.b.c.) from the spleen, nor to an increase in r.b.c. volume.3. The observed decrease in plasma volume was large enough to explain the drinking response to renin and angiotensin. Renin may thus induce or aggravate hypovolaemia rather than signalling its occurrence to hypothalamic receptors. PMID- 4325608 TI - Differentiation between the actions of acetylcholine and tetramethylammonium on the isolated taenia of the guinea-pig caecum by hemicholinium-3. AB - 1. Contractions of the isolated taenia of the guinea-pig caecum produced by acetylcholine and TMA were examined in the presence of various antagonists and anticholinesterases.2. Hemicholinium-3 (HC-3) (50-400 mug/ml) inhibited contractions or relaxations produced by TMA but not contractions produced by acetylcholine. The inhibition was rapid in onset and readily reversible. Contractions produced by transmural stimulation were unaffected by HC-3 but responses produced by nicotine were inhibited.3. Low concentrations of hyoscine and benzhexol inhibited responses to acetylcholine to a greater extent than those to TMA.4. Morphine, raised concentrations of Mg(++) or reduced concentrations of Ca(++) inhibited contractions produced by TMA and by acetylcholine to a similar extent.5. Edrophonium, in concentrations which preferentially inhibit acetylcholinesterase, increased contractions produced by acetylcholine and converted responses to nicotine or transmural stimulation into contractions or biphasic responses with a marked contraction phase but did not increase contractions produced by TMA.6. Iso-OMPA, in concentrations which preferentially inhibit butyrylcholinesterase, had no effect on responses to acetylcholine, nicotine, transmural stimulation or TMA.7. HC-3 inhibited contractions produced by TMA in the presence of anticholinesterases but had little effect on contractions produced by acetylcholine.8. These results suggest that TMA produces contractions by acting directly on receptors of the smooth muscle. An analysis of possible reasons for HC-3 (in the concentrations used) acting as an antagonist of TMA but not of acetylcholine indicates that the findings do not necessarily contradict the interpretation that both agonists act on the same receptor. PMID- 4325609 TI - Hypertension and chronic renal failure. PMID- 4325610 TI - Sore throat in children: its causation and incidence. AB - Beta-haemolytic streptococci were isolated from 35% of 525 children who presented to their family doctors with sore throat. The first 306 were investigated bacteriologically and virologically and beta-haemolytic streptococci were isolated from 30% and viruses from 14.7%. The ages which had the highest incidence of sore throat, for both sexes, were 7, then 6, 8, and 5. Those with tonsils had a higher incidence of beta-haemolytic streptococci than those without, but the presence or absence of tonsils made no difference to the degree of growth of the streptococci.Viruses were isolated predominantly during the winter months, but streptococci, though mostly isolated in winter, were isolated throughout the rest of the year. PMID- 4325611 TI - Cytologic studies of tumors. 48. Chromosomes of nine primary rat hepatomas induced by administration of 3'-methyl-4-dimethylaminoazobenzene. PMID- 4325612 TI - [Hybridization of mammalian somatic cells and spermatozoa. Penetration and early morphological changes of stallion spermatozoa in Chinese hamster cells]. PMID- 4325613 TI - Acute effect of corticotropin on the incorporation of 3H-choline into phospholipid fraction of subcellular components from rat adrenal glands. PMID- 4325614 TI - Further investigations on specificity and precision in the Igarashi-McCann FSH assay method. PMID- 4325615 TI - [Angiographic and scintigraphic findings on the kidney in Pringle's syndrome (adenoma sebaceum)]. PMID- 4325616 TI - Burkitt lymphoblasts and their Epstein-Barr virus. Synthesis of viral DNA and proteins in arginine deprived cells. PMID- 4325617 TI - Duration of masseteric silent period in patients with TMJ syndrome. PMID- 4325618 TI - Pre-ovulatory progesterone, the adrenal cortex and the 'critical period' for luteinizing hormone release in rats. PMID- 4325619 TI - The regulation of insulin secretion by the ovine foetus in utero. PMID- 4325620 TI - Scintiphotographic evaluation of response of brain neoplasms to systemic chemotherapy. PMID- 4325621 TI - The effect of potassium perchlorate on the uptake of 99mTc-pertechnetate in choroid plexus papillomas: a report of two cases. PMID- 4325623 TI - Steatorrhoea in the Punjab: the results of a village survey. PMID- 4325624 TI - Purification and some properties of kappa toxin of Clostridium perfringens. PMID- 4325622 TI - The synthesis, turnover and release of surplus acetylcholine in a sympathetic ganglion. AB - 1. Surplus acetylcholine (ACh) is the extra ACh that accumulates in cholinergic nerve endings when they are exposed to an anticholinesterase agent. The synthesis and turnover of this ACh was examined in the cat's superior cervical ganglion.2. Surplus ACh did not accumulate in chronically decentralized ganglia perfused with eserine-choline-Locke solution, and this shows that it is stored in presynaptic nerve terminals.3. Surplus ACh accumulated more rapidly in ganglia perfused with eserine than in ganglia perfused with neostigmine or with ambenonium; accumulation was delayed by 45-60 min when a quaternary anticholinesterase was used. However, the release of ACh upon preganglionic nerve stimulation was the same during perfusion with eserine, neostigmine or ambenonium. It is concluded that intracellular acetylcholinesterase normally destroys surplus ACh, whereas extracellular enzyme destroys released ACh.4. When ganglia were perfused with [(3)H]choline and eserine, the surplus ACh that accumulated was labelled but its specific radioactivity was only 38% of that of the choline added to the perfusion fluid.5. Surplus ACh was not released by nerve stimulation and was not mobilized for release during, or after, prolonged nerve stimulation. It is concluded that ACh released by nerve impulses is replaced by synthesis at the site of ACh storage and not by movement of ACh from the surplus pool.6. The accumulation of surplus ACh no more than doubled the total ACh content of ganglia, but turnover of ACh continued when the total amount was constant. Surplus ACh may contribute to spontaneous ACh output from eserinized preparations.7. When ganglia were perfused with a medium containing high K(+) (56 mM), surplus ACh was released. PMID- 4325625 TI - Neuromuscular blocking actions of nereistoxin and its derivatives and antagonism by sulfhydryl compounds. PMID- 4325626 TI - Action of dibutyryl cyclic adenosine monophosphate on the intestinal smooth muscle. PMID- 4325627 TI - [Radio-immunological determination of angiotensin. II. Personal experiences with methodology]. PMID- 4325628 TI - [Efficacy of a synthetic ACTH preparation as evaluated by the Weissbecker test]. PMID- 4325629 TI - [Corticostimulation test after steroid therapy in consecutive and alternating days]. PMID- 4325630 TI - [Personal experience with corticosteroid therapy of nephrosis in childhood]. PMID- 4325631 TI - [Blood cortisol in children previously treated with ACTH]. PMID- 4325632 TI - [EEG findings in nephrotic children in the course of corticosteroid therapy]. PMID- 4325633 TI - [Determination of plasma and cerebrospinal fluid cortisol in relation to corticosteroid and corticotropin therapy as a means of evaluating the transfer capacity of glucosteroids across the hemato-encephalic barrier]. PMID- 4325635 TI - [A new type of silicates]. PMID- 4325634 TI - [Clinical and biological activity of synthetic and extracted ACTH in therapy of lipoid nephrosis]. PMID- 4325636 TI - [Depot corticotropin in a screening test for adrenocortical insufficiency. A comparison between depot-ACTH (Jaton prolongatum "A-L") and depot-tetracosactid (Synacthen Depot "Ciba")]. PMID- 4325637 TI - [Neurographic results with distal compression of the median nerve--before, after and during operation]. PMID- 4325638 TI - [Formation of early and late polyribosomes and the template activity of viral ribonucleoprotein]. PMID- 4325640 TI - [Emergence of herpesvirus from cells]. PMID- 4325639 TI - [Replication complexes of some RNA viruses]. PMID- 4325641 TI - [Purification and some properties of Cl. perfringens lecithinase]. PMID- 4325642 TI - [Effect of hypoxia and 2,4-dinotrophenol on lactate dehydrogenase activity in brain, liver and kidneys]. PMID- 4325643 TI - [Current problems in virus research]. PMID- 4325644 TI - [Course and treatment of Herpesvirus hominis infections. I. Epidemiology, clinical picture and serology]. PMID- 4325645 TI - [Wing removal as a factor stimulating egg maturation in insects (using Eurygaster integriceps Put. as an example)]. PMID- 4325647 TI - [Phenomenon of compensatory hypertrophy connected with the presence of a DAB hepatoma in the rat]. PMID- 4325646 TI - Excretion of tryptophan metabolites as affected by pregnancy, contraceptive steroids, and steroid hormones. PMID- 4325649 TI - Growth promotion by extracts from Wilms' tumor in vitro. PMID- 4325648 TI - Presynaptic depolarization of olfactory afferent fibers in cat prepyriform cortex. PMID- 4325650 TI - Demonstration of virus particles in ovine pulmonary adenomata. PMID- 4325651 TI - Growth inhibitory effects of adenosine 3',5'-monophosphate on mouse leukemia L 5178-Y-R cells in culture. PMID- 4325652 TI - On the synthesis of poliovirus RNA at supraoptimal temperatures. PMID- 4325653 TI - Mixed tumour of the uterus (report of a case and review of literature). PMID- 4325654 TI - [A case of diffuse carcinosis of the subarachnoid space]. PMID- 4325655 TI - Activation of host lymphocytes cultured with cancer cells treated with neuraminidase. PMID- 4325656 TI - Nucleotide composition of RNA hybridized to homologous DNA from cells transformed by avian tumour viruses. PMID- 4325657 TI - Morphine and nalorphine impair neuromuscular transmission. PMID- 4325658 TI - [Vascular pathological peculiarities of certain tumors of the nervous system]. PMID- 4325659 TI - [Clinical and therapeutical considerations on various cases of autoimmune hemolytic anemia]. PMID- 4325660 TI - Mucinous carcinoma of the prostate. Case report. PMID- 4325661 TI - [Avoidance and treatment of complications caused by myelography]. PMID- 4325662 TI - [A simple, dynamic splint for the after care following surgical interventions on the metacarpo-phlangeal joints in PcP]. PMID- 4325663 TI - Pituitary-adrenocortical stimulation in the aged as reflected in levels of plasma cortisol and compound S. PMID- 4325664 TI - Pulmonary cytomegalovirus infection in the adult. PMID- 4325665 TI - Herpes simplex encephalitis. A radiologic-pathologic study of 4 cases. PMID- 4325666 TI - Herpes simplex encephalitis. PMID- 4325667 TI - Oxygen uptake, ventilation, and heart rate. Study in Negro children during strenuous exercise. PMID- 4325668 TI - An epidemic of food-associated pharyngitis and diarrhea. PMID- 4325669 TI - Membrane condensing effect of cholesterol and the role of its hydroxyl group. PMID- 4325670 TI - Induction of the site I phosphorylation in vivo in Saccharomyces carlsbergensis. PMID- 4325671 TI - Melanocyte stimulating activities of the o-nitrophenyl sulfenyl derivatives of adrenocorticotropin and [5-glutamine]-alpha-melanotropin. PMID- 4325673 TI - Structural polypeptides of three rhinoviruses. PMID- 4325672 TI - Divergent effects of o-nitrophenyl sulfenyl ACTH on rat and rabbit fat cell adenyl cyclases. PMID- 4325674 TI - Studies on the specificity of bacterial collagenase. PMID- 4325675 TI - Far-infrared studies on hemin and hemin-like complexes. PMID- 4325676 TI - Effect of pyrophosphate on the exchangeable calcium pool of hydroxyapatite crystals. PMID- 4325677 TI - Subcellular localization of nicotinamide deamidase in rat liver. PMID- 4325678 TI - Adenyl cyclase of cell nuclei isolated from rat ventral prostate. PMID- 4325679 TI - Adenyl cyclase activity in rat liver nuclei. PMID- 4325680 TI - Studies on glycogen synthetase interconverting enzymes in in vitro perfused compared to non-perfused rat hearts. PMID- 4325682 TI - Studies on the composition of extracellular fluid from calf costal cartilage. PMID- 4325681 TI - Glycogen synthesis and glycogen synthetase in rat ascites hepatomas of low and high glycogen content. PMID- 4325683 TI - Conversion of chorismic acid and isochorismic acid to salicylic acid by cell-free extracts of Mycobacterium smegmatis. PMID- 4325684 TI - Morphological transformation of mouse and rat embryo cells in vitro by an agent from S37 ascites tumour. AB - When normal rat and mouse embryo cells were treated with a cell free extract of S37 ascites tumour, morphological transformations occurred in both. The transformed cells readily induced lymphosarcoma-type tumours in the mice inoculated when newborn or young adults (8-12 weeks old), but not so readily in rats.Various tests carried out with these cells strongly indicate the presence of an oncogenic and transmissible agent in S37 ascites tumour. This agent appears to be related to mouse sarcoma virus isolated from animals with Moloney leukaemia but differs in only producing characteristic lymphosarcoma-type tumours. PMID- 4325685 TI - [Therapeutic action of digitalis and substances with analogous action. Lecture 3]. PMID- 4325686 TI - The meta cleavage of catechol by Azotobacter species. 4-Oxalocrotonate pathway. PMID- 4325687 TI - Acidic structural proteins of connective tissue. Characterization of their heterogeneous nature. PMID- 4325688 TI - [Studies on nephrotoxicity of antibiotics]. PMID- 4325689 TI - Acute bloat syndrome in stumptailed macaques (Macaca arctoides): a report of four cases. PMID- 4325690 TI - Amyloidosis and renal paramyloid in a closed hamster colony. PMID- 4325691 TI - An evaluation of the mouse antibody production test for detecting three murine viruses. PMID- 4325692 TI - A laminar flow system for animal maintenance. PMID- 4325693 TI - Trichosomoides crassicauda infection of a commercial rat breeding colony. II. Drug screening for anthelmintic activity and field trials with methyridine. PMID- 4325694 TI - Acepromazine and methoxyflurane anesthesia of immature New Zealand white rabbits. PMID- 4325695 TI - Experimental study of pulmonary adenomas in the opossum (Didelphis virginiana). PMID- 4325696 TI - Osteomalacia in captive flying squirrels, Glaucomys volans. PMID- 4325697 TI - Postoperative management of experimental thoracic surgery in the dog. PMID- 4325698 TI - Idiopathic muscle necrosis with apparent myoglobinuria in Macaca arctoides. PMID- 4325699 TI - A technique for the treadmill training of beagle dogs. PMID- 4325700 TI - Hematologic values for laboratory reared Marmosa mitis. PMID- 4325701 TI - The goat as an artificial ventilation model. PMID- 4325702 TI - General anesthesia in rabbits using methoxyflurane, nitrous oxide, and oxygen. PMID- 4325704 TI - Stocks for holding unanesthetized dogs in the standing position. PMID- 4325703 TI - Acute pasteurellosis in owl monkeys (Aotus trivirgatus). PMID- 4325705 TI - A note on the lens in aging Sprague-Dawley rats. PMID- 4325706 TI - Laboratory housing for the pony in an urban research facility. PMID- 4325707 TI - Reactions to fluphenazine hydrochloride by two adult male macaques. PMID- 4325708 TI - Electrophoretic analyses of normal beagle serum proteins. PMID- 4325709 TI - Passive haemagglutination test for anti-rhinovirus antibodies. PMID- 4325710 TI - Interactions of vesicular stomatitis virus structural proteins with HeLa plasma membranes. PMID- 4325711 TI - Forssman antigen exposed on surface membrane after viral transformation. PMID- 4325712 TI - Murine leukaemia C-type virus associated with functional murine carcinomas of endocrine origin. PMID- 4325713 TI - Action of angiotensins and synthetic renin substrate on isolated rat colon. PMID- 4325714 TI - Adrenergic inhibition in mammalian parasympathetic ganglia. PMID- 4325715 TI - Simultaneous recording of input and output of lateral geniculate neurones. PMID- 4325716 TI - [Cholinergic and dopaminergic mechanisms in Huntingtons' chorea]. PMID- 4325717 TI - [Parapharyngiomas: clinical and radiological considerations]. PMID- 4325718 TI - Distribution of peripheral neuropathy in diabetic amputees. PMID- 4325719 TI - [Linitis plastica in the colon and the rectum]. PMID- 4325720 TI - [Analysis of the 1st immediate results of treatment of malignant neoplasms with high-energy protons]. PMID- 4325721 TI - [Complex study for evaluating a serological test for diagnosing primary liver cancer]. PMID- 4325722 TI - [New method of cytological study of liver puncture biopsies]. PMID- 4325723 TI - Intestinal haemorrhage syndrome in artificially-reared lambs. PMID- 4325724 TI - Coccidiosis with concurrent Marek's disease. PMID- 4325725 TI - Studies on the effect of prostaglandins E1 and E2 on the sympathetic neuromuscular transmission in some animal tissues. PMID- 4325726 TI - [Clinico-statistical aspects of tumors of the mediastinum. (Study based on 360 cases)]. PMID- 4325727 TI - [Studies on swine. 35. Observations on animals with adrenocortical regeneration after bilateral adrenalectomy]. PMID- 4325728 TI - [pH inactivation of the foot-and-mouth disease virus]. PMID- 4325729 TI - [The effect of DEAE-dextran on the infectiousness of ribonucleic acid preparations of foot-and-mouth disease virus in various host systems]. PMID- 4325730 TI - [Studies on Marek's disease of chickens. I. Evidence of acute Marek's disease in a hatching, pullet-raising and broiler-fattening business infected with infectious bronchitis, avian adenovirus infection and mycoplasmosis; its spread by animal trade]. PMID- 4325731 TI - [The morphological development of the virus of transmissible gastroenteritis as compared to other viruses]. PMID- 4325732 TI - [Observations on virological work with swine thyroid cell-cultures]. PMID- 4325733 TI - [Determination of the size of viruses using gel electrophoresis]. PMID- 4325734 TI - [The production of serum precipitins as evidence of the virus of infectious bronchitis, infectious laryngotracheitis and fowl pox, as well as of avian adenovirus (CELO)]. PMID- 4325735 TI - [Mixed infections of avian adenovirus and the virus of infectious bronchitis]. PMID- 4325736 TI - [Serodiagnosis of ectromelia in laboratory mice]. PMID- 4325737 TI - [Detoxicating effects of poly-2-vinylpyridine-N-oxide]. PMID- 4325738 TI - Control of basal insulin secretion, with special reference to the diagnosis of insulinomas. AB - Estimation of plasma glucose and immunoreactive insulin concentrations in normal subjects after an overnight fast showed that subjects with high basal plasma glucose levels tended to have high plasma insulin concentrations. A similar correlation between glucose and insulin levels was seen in patients with obesity and various endocrine disorders. The suppression of plasma insulin levels associated with hypoglycaemia was used to derive an "amended insulin-glucose ratio," which appeared to be a good discriminant for the diagnosis of insulinomas. In normal subjects the ratio was less than 30 muU insulin/mg glucose, in obese subjects less than 50 muU/mg, and most of the patients with insulinomas had values over 200 muU/mg. PMID- 4325739 TI - Treatment of myasthenia--I. PMID- 4325740 TI - Overdosage of tetracosactrin in rheumatoid arthritis. PMID- 4325741 TI - Altered pattern of metastasis following treatment of Ewing's sarcoma with radiotherapy and adjuvant chemotherapy. PMID- 4325742 TI - Modal DNA value and chromosome number in ovarian neoplasia. A clinical and histopathologic assessment. PMID- 4325743 TI - Acetylenic carbamate in childhood cancer. PMID- 4325745 TI - Fine structure of the extramammary Paget's cell. PMID- 4325744 TI - Human carcinoma of the breast, in vitro: the effect of hormones. A prelininary report. PMID- 4325746 TI - Role of myoepithelial cells in the development of salivary gland tumors. PMID- 4325747 TI - Gluconeogenesis in rat liver cytosol. II. Computer simulation of control properties. PMID- 4325748 TI - Gluconeogenesis in rat liver cytosol. I. Computer analysis of experimental data. PMID- 4325749 TI - Treatment of malignant insulinoma with Streptozotocin. PMID- 4325750 TI - [Concerning an outbreak of adenoviral infections]. PMID- 4325751 TI - Double internal standard for quantitative determinations of free radicals. PMID- 4325752 TI - Electron spin resonance studies on living cells. 1. The eggs and embryos of amphibians. PMID- 4325753 TI - The effect of the phenoxyacetic acid derivatives on the enzymatic activity of the placenta in guinea-pigs. PMID- 4325754 TI - Histochemical investigations on the activity of some phosphatases in skeletal muscles of mice under the influence of infection with Trichinella spiralis. PMID- 4325755 TI - Laboratory studies on the varicella-zoster virus. PMID- 4325756 TI - Anorexic behavior: a nursing problem. PMID- 4325757 TI - Family-oriented health care: is the interdisciplinary health team necessary? PMID- 4325758 TI - Crisis: moment of truth. PMID- 4325759 TI - The nursing contract: an alternate in care. PMID- 4325760 TI - The multifaceted role of the community mental health nurse. PMID- 4325762 TI - Suicide in the aged. PMID- 4325761 TI - The social sciences in medical education. PMID- 4325764 TI - A study of hypertension. The actions of synthetic angiotensin II on adrenal and myocardial catecholamines. PMID- 4325765 TI - Inhibitory activity of guanidine on poliovirus proteins. PMID- 4325766 TI - Comparison of calculated and measured surface dose using LiF discs. PMID- 4325767 TI - Alteration of postirradiation hypotension and incapacitation in the monkey by administration of vasopressor drugs. PMID- 4325768 TI - Resistance to Rous sarcoma elicited by immunization with live virus. PMID- 4325769 TI - Vascular ionic effects of angiotension II in the rat. PMID- 4325770 TI - Insensitivity of adipocytes of hypophysectomized rats to growth hormone and insulin. PMID- 4325771 TI - Chromosome lesions induced in a human hematopoietic cell line by infection with Epstein-Barr virus. PMID- 4325772 TI - Effects of endogenous thyrocalcitonin and vitamin D3 on milk yield in parathyroidectomized and thyroparathyroidectomized rats. PMID- 4325773 TI - Production of an interferon-like agent following inoculation with bacterial vaccine. PMID- 4325774 TI - An inhibitor of herpesvirus hominis in extracts of cultures of Burkitt's lymphoma cells. PMID- 4325775 TI - Effects of ACTH on voles (Microtus pennsylvanicus) related to reproductive function and renal disease. PMID- 4325776 TI - Suppression of herpes simplex virus infection by antimitotic substances in the rabbit cornea. PMID- 4325777 TI - Inhibition of spontaneous mammary carcinoma of mice by treatment with interferon and poly I:C. PMID- 4325778 TI - In vivo enhancement of a murine sarcoma virus by diethylaminoethyl-dextran. PMID- 4325779 TI - Assay of cyclic 3',5'-nucleotide phosphodiesterase in tissue homogenates. PMID- 4325780 TI - Identification of radiation-induced hydrogen-addition radicals in adenine derivatives. PMID- 4325781 TI - The new quartz-filled resins. 2. Clinical application. PMID- 4325782 TI - [Cultivation of equine infectious anemia virus]. PMID- 4325783 TI - [Effect of plant bitter substances on sheep digestion]. PMID- 4325784 TI - [Present-day experience in tracheal surgery]. PMID- 4325785 TI - Thromboplastic and fibrinolytic properties of three transplantable rat tumours. PMID- 4325786 TI - The induction of tumours with Rous sarcoma virus in Microtus agrestis: a preliminary note. PMID- 4325787 TI - Investigation of immunizing properties as well as interferogenicity of some murine leukemia viruses. PMID- 4325788 TI - [Proteins of animal ribosomes. IV. Antigenic properties of ribosomes and ribosomal proteins from liver and hepatoma]. PMID- 4325789 TI - [Enzymes of the glycolysis and the glucose shunt in precancerous rat liver and in hepatomas]. PMID- 4325790 TI - [Action of N-dimethyldiphenoxyethylamine on the resorption of norepinephrine by sympathetic nerve endings]. PMID- 4325791 TI - [Experimental study of the neuro-muscular and cardiovascular actions of an aminoglucosidic antibiotic, gentamicin]. PMID- 4325792 TI - [Cyclic adenosine monophosphate and turn-over of inorganic phosphate in certain phospholipid fractions of the rat pancreas]. PMID- 4325793 TI - Properties of polyoma virus transformed cells. I. Oncogenic properties. PMID- 4325794 TI - The recovery of polyoma virus from infected mouse cells: relevance to virus purification. PMID- 4325795 TI - Comparison of herpes simplex antigens prepared from various tissues. PMID- 4325796 TI - [Diagnostic problems in Wilms' tumor]. PMID- 4325797 TI - [Cellular differentiation and antibody synthesis in oncology]. PMID- 4325798 TI - [Diagnosis of bone metastasis of prostatic carcinoma with strontium 87m and Anger camera]. PMID- 4325799 TI - Electron microscopical studies on the lysosomes and the Golgi apparatus in the motoneurons of spinal cords of mice under physiological and pathological conditions. PMID- 4325801 TI - Lung tumors of primates and rodents. 3. PMID- 4325800 TI - [Histochemical, fluorescence microscopy and experimental studies on the impulse conducting system of golden hamsters, mice and rats]. PMID- 4325803 TI - The influence of oxygen on the E.S.R. spectrum of a radiosensitizing nitroxide. PMID- 4325802 TI - Adenine complexes of thymine and uracil: electron spin resonance and thermoluminescence investigations. PMID- 4325805 TI - Comparative morphologic study of bronchoalveolar cancer and pulmonary adenomatous changes in man. PMID- 4325804 TI - A controlled field trial for an evaluation of effectiveness of mouse-brain Japanese encephalitis vaccine. PMID- 4325806 TI - Carcinoma of the vulva. PMID- 4325807 TI - Skin disorders in pregnancy. PMID- 4325808 TI - Abdominal wall pain due to nerve entrapment. PMID- 4325809 TI - [Electrooculographic study of eye movements during the paradoxical phase of sleep]. PMID- 4325810 TI - [Effects of repetitive stimulations during neuropathies due to vincristine. Preliminary observations]. PMID- 4325811 TI - [Data on motor nerve pathology of the limbs in medical diseases. Possibility of proximal injury with distal exitability preservation]. PMID- 4325812 TI - Quantal mechanism of neural transmitter release. PMID- 4325814 TI - [Glioblastoma multiforme in the course of Recklinghausen's disease]. PMID- 4325813 TI - The susceptibility of 168 strains of salmonellae to eleven anti-microbial agents. PMID- 4325815 TI - [Current concepts of the value of hormonal therapy of the nephrotic syndrome in childhood]. PMID- 4325816 TI - [Tuberculostatic tolerance of a tuberculous kidney]. PMID- 4325817 TI - [Ambulatory after care of patients with urogenital tuberculosis]. PMID- 4325818 TI - [Diagnosis of congenital cytomegaly from the perspective of etiologic treatment: a case]. PMID- 4325819 TI - Papillary hidradenoma of the vulva: a clinicopathologic study of 69 cases. PMID- 4325820 TI - Serum placental lactogen activity in patients with molar pregnancy and trophoblastic tumors--a reliable index of malignancy. PMID- 4325821 TI - Roentgenographic manifestations of Klinefelter's syndrome. PMID- 4325822 TI - Detection of avian leukosis viruses in chickens by an in vivo Rous sarcoma virus genome rescue test. PMID- 4325823 TI - The effect of DMSO and cultural behavior of two herpesviruses associated with Marek's disease. PMID- 4325824 TI - Field trials of vaccines for Marek's disease. PMID- 4325825 TI - Long-term studies of Marek's disease infection in individual chickens. PMID- 4325826 TI - Effect of vaccination with herpesvirus of turkeys (HVT) on horizontal spread of Marek's disease herpesvirus. PMID- 4325827 TI - Multiple molecular forms of xanthine dehydrogenase and related enzymes. IV. The relationship of aldehyde oxidase to xanthine dehydrogenase. PMID- 4325828 TI - Mitochondrial polymorphism. 3. Heterosis, complementation, and spectral properties of purified cytochrome oxidase of wheat. PMID- 4325829 TI - Characterization of hypoxanthine-guanine phosphoribosyl transferase in man--mouse somatic cell hybrids by an improved electrophoretic method. PMID- 4325830 TI - Inhibitors of haemaggregation in biological fluids. PMID- 4325831 TI - The nature of experimental second-set kidney transplant rejection. 2. The mimicking of the haemodynamic upset by pharmacological and other means. PMID- 4325832 TI - Assay of endotoxin by the hypothermic response of mice. PMID- 4325833 TI - [Intra- and juxta-articular tumors and some of their peculiarities]. PMID- 4325834 TI - Isolation and partial characterization of a glyceraldehyde 3-phosphate dehydrogenase-inactivating factor from Ehrlich ascites tumor cells. PMID- 4325836 TI - Ultrastructural and biological properties of a cytomegalovirus rescued from a human paraganglioma. PMID- 4325835 TI - Absence of an effect of partial hepatectomy on aflatoxin B 1 carcinogenesis. PMID- 4325837 TI - Behavior of opposing pathways of thymidine utilization in differentiating, regenerating, and neoplastic liver. PMID- 4325838 TI - Regulation of adenyl cyclase in hepatomas of different growth rates. PMID- 4325839 TI - Distinctive properties of ferritin from the Reuber H-35 rat hepatoma. PMID- 4325840 TI - Transfer RNA and transfer RNA methylase in human brain tumors. PMID- 4325842 TI - Transfer RNA's of embryonic tissue. PMID- 4325841 TI - Agents of modulation of the transfer RNA methylases. PMID- 4325843 TI - Studies on transfer RNA-Phe from Morris 5123C hepatoma. PMID- 4325844 TI - Application of a tritium derivative method to human brain and brain tumor transfer RNA analysis. PMID- 4325845 TI - Transfer RNA modifications and synthesis in animal cells. PMID- 4325847 TI - [Comparison of phases of natural sleep with the effect of phenamine and aminazin and the evaluation of the mean frequency of extremes of ECoG in cats]. PMID- 4325846 TI - Modification of the cardiovascular effects of L-dopa in anesthetized dogs by inhibitors of enzymes involved in catecholamine metabolism. PMID- 4325848 TI - [Effect of choridine and sulfadimezine on the content of coenzyme forms of nicotinic acid in the blood and organs of albino rats]. PMID- 4325849 TI - Further manifestations of abortive transformation of BHK 21 cells by polyoma virus. PMID- 4325850 TI - Cellular immunity to nephroblastoma. PMID- 4325851 TI - Isoenzyme and protein profiles of normal, leukemic and fetal mouse tissues. PMID- 4325852 TI - Concomitant immunity in hamsters bearing syngeneic transplants of tumors induced by para-adenovirus 7, simian adenovirus 7, or 9,10-dimethylbenzanthracene. PMID- 4325853 TI - Electron microscopic detection of transforming viruses induced by cell association. I. The SV40 model. PMID- 4325854 TI - Effects of population density and living space upon neuroanatomy, neurochemistry, and behavior in the C57B1-10 mouse. PMID- 4325855 TI - Forebrain pathways of reward in Rattus norvegicus. PMID- 4325856 TI - Diagnosis of hepatic tumors by liver scintiscanning. PMID- 4325857 TI - The effect of tolbutamide on blood pressure. PMID- 4325858 TI - Adenyl cyclase in human leukocytes: evidence for activation by separate beta adrenergic and prostaglandin receptors. PMID- 4325859 TI - [Viruses and cervical carcinoma]. PMID- 4325860 TI - [Radiotherapy of glomus jugulare tumors with endocranial expansion]. PMID- 4325861 TI - Production of recessive lethals in Drosophila by viruses non-infectious for the host. PMID- 4325862 TI - Skeletal metastasis in primary carcinoma of the liver. PMID- 4325863 TI - 1,25-dihydroxycholecalciferol: identification of the proposed active form of vitamin D3 in the intestine. AB - The major polar metabolite of cholecalciferol (vitamin D(3)) present in chick intestinal mucosa has been chemically characterized by mass spectrometric analysis to have a molecular formula of C(27)H(44)0(3) and a structure of 1,25 dihydroxycholecalciferol. This compound, which is produced in the kidney from 25 hydroxycholecalciferol, has been previously shown to be from 4 to 13 times as active as cholecalciferol in stimulating intestinal calcium transport. 1,25 Dihydroxycholecalciferol (previously designated metabolite 4B in this (laboratory) probably represents the biologically active form of cholecalciferol in the intestine. PMID- 4325864 TI - Fertilization of rabbit ova in vitro by sperm with adsorbed Sendai virus. AB - Fertilization occurs when rabbit ova are cultured in vitro with epididymal sperm to which Sendai virus is adsorbed. These sperm do not require capacitation in vivo in order to fertilize. Evidence for fertilization is penetration of sperm, the appearance of two polar bodies and pronuclei, and cleavage through the eight blastomere stage. The viruses attach almost exclusively to the sperm acrosome, with resultant head-to-head agglutination of the sperm. PMID- 4325865 TI - Angiotensin-forming enzyme in brain tissue. AB - A renin-like enzyme is present in brain tissue and is independent of kidney and plasma renin. In the presence of homologous substrate it forms angiotensin. Administration of aldosterone significantly decreases this angiotensinforming enzyme activity, while administration of progesterone markedly enhances it. PMID- 4325866 TI - Erythrocytes: pits and vacuoles as seen with transmission and scanning electron microscopy. AB - Vacuoles containing inclusions were observed by transmission electron microscopy in erythrocytes of a splenectomized patient with hemoglobin Ann Arbor. The membranes of these vacuoles became fused with the surface membrane of the red cell, thus opening the vacuoles and exposing their contents to the outside. These vacuoles when they have become thus attached to the cell membrane of the erythrocyte are responsible for the pits observed with scanning electron microscopy. PMID- 4325867 TI - Antiviral activity of polyribocytidylic acid in cells primed with polyriboinosinic acid. AB - Separate administration of polyribocytidylic acid [poly(rC)] and polyriboinosinic acid [poly(rI)] to cell cultures in vitro resulted in an antiviral activity identical to or greater than that resulting from addition of the poly(rI) * poly(rC) complex. Priming of cells with poly(rI), followed by treatment with poly(rC), gave a consistently greater antiviral activity than poly(rI) * poly(rC) itself. This priming effect was obtained in several cell cultures challenged with different viruses. In vivo, the antiviral activity of poly(rI) * poly(rC) was only partially restored if poly(rI) and poly(rC) were injected separately; prior injection of poly(rI) proved superior in restoring this antiviral activity as compared to prior injection of poly(rC). PMID- 4325868 TI - [The effect of actinomycin D on DNA synthesis in SV 40 infected exponentially growing and stationary cells]. PMID- 4325869 TI - [Epidemiology of adenovirus infections]. PMID- 4325870 TI - [Characteristics of Bordetella pertussis soluble antigens]. PMID- 4325871 TI - [Identification of Cl. perfringens types B, C, and F in tissue culture]. PMID- 4325872 TI - [Hybride-ionic amino acids as buffers in electromicroscopy. Studies on the brain of Enchytraeus albidus (annelida-oligochaeta)]. PMID- 4325873 TI - [Behavior of LL-hydroxycorticosteroid and glucose concentration in pig plasma after ACTH administration]. PMID- 4325874 TI - On the presence of particular nuclear inclusions in cells of various mammalian tissues. PMID- 4325875 TI - Interrelationship between fatty acid oxidation and gluconeogenesis from pyruvate. PMID- 4325876 TI - Probes for the conformational transitions of phosphorylase b. Effect of ligands studied by proton relaxation enhancement, fluorescence and chemical reactivities. PMID- 4325877 TI - Anaerobic oxidation-reduction titrations of human ceruloplasmin. Evidence for diamagnetic electron-acceptors in the protein. PMID- 4325878 TI - Studies of glutamate dehydrogenase. The x-ray small-angle investigation of the beef liver glutamate dehydrogenase oligomer. PMID- 4325879 TI - Increased fatty acid synthesis of arterial tissue in hypoxia. PMID- 4325880 TI - Fusion of rabbit spermatozoa with somatic cells cultivated in vitro. PMID- 4325881 TI - Ultrastructural localization of cytochrome oxidase in isolated rat thymus nuclei by the diaminobenzidine method. PMID- 4325882 TI - A method of isolating cells incapable of multiplication in suspension culture. PMID- 4325883 TI - Phenotypic variation and its control in polyoma-transformed BHK21 cells. PMID- 4325884 TI - Induction of vacuolation in the mouse peritoneal macrophage by EDTA. PMID- 4325885 TI - Estimation of the non-tumor fraction of a solid tumor from area measurements of electron micrographs. PMID- 4325886 TI - [In vitro studies on the biosynthesis of corticosteroids in rat adrenal glands and the action of ACTH. I. Biosynthesis of corticosteroids from endogenous precursors]. PMID- 4325888 TI - Protein synthesis and uptake by isolated Cecropia oocytes. PMID- 4325887 TI - The analysis of malignancy by cell fusion. 3. Hybrids between diploid fibroblasts and other tumour cells. PMID- 4325889 TI - Clinicopathological conference of the Medical University of South Carolina. "27 year-old woman with intractable ascites". PMID- 4325890 TI - Infectious disease and social change. 2. PMID- 4325891 TI - [Differential diagnosis of alveococcosis and primary cancer of the liver]. PMID- 4325892 TI - Ectopic production of parathyroid hormone by carcinoma of the breast. PMID- 4325894 TI - Sleepy interns. PMID- 4325893 TI - The cytomegaloviruses: ubiquitous agents with protean clinical manifestations. I. PMID- 4325895 TI - Exogenous reinfection with herpes-simplex virus. PMID- 4325896 TI - Pulmonary complications of lymphography. PMID- 4325897 TI - [Endocrine (secreting and apparently inert) tumors of the pancreas]. PMID- 4325898 TI - ESR-studies of the mechanism of radiosensitization. Action of N-ethylmaleimide on irradiated sulfhydryl compounds, irradiated DNA, and irradiated nucleotides. PMID- 4325899 TI - The influence of temperature on radiation-induced oxygen-dependent and independent damage in barley seeds. PMID- 4325900 TI - [Factors determining the level of virus production. 2. The effect of conditions of cultivation on the production of several RNA-containing viruses]. PMID- 4325902 TI - [The specificity of Sendai virus neuraminidase]. PMID- 4325901 TI - [The toxic effect of vesicular stomatitis virus on mouse peritoneal exudate phagocytes]. PMID- 4325903 TI - [The course of experimental adenovirus infection in newborn hamsters]. PMID- 4325905 TI - [Presence of incompetent virus particles in a strain of Moloney sarcoma virus passed in mice]. PMID- 4325904 TI - [Characteristics of strains of smallpox virus isolated from various forms of the disease]. PMID- 4325906 TI - [Stimulation of viral reticulosarcomatosis in CC57BR-Mv mice by complete Freund's adjuvant]. PMID- 4325907 TI - [Extraction of S-antibodies to Sendai virus by isolation from a specific precipitate]. PMID- 4325908 TI - [Malignant degeneration of a mixed tumor of the parotid gland]. PMID- 4325909 TI - A review of composites. PMID- 4325910 TI - The new quartz-filled resins. 1. PMID- 4325911 TI - Congenital epulides of the newborn: diagnosis and management. PMID- 4325912 TI - Collagenase studies of gingivae of man. PMID- 4325913 TI - Synergistic effect in viral-bacterial infection. 3. Histopathological changes in the trachea of mice following viral and bacterial infection. PMID- 4325914 TI - Synergistic effect in viral-bacterial infection. 5. Functional studies on the role of the ciliary activity in the mouse trachea. PMID- 4325915 TI - Effects of a myocardial depressant factor on isolated vascular smooth muscle. PMID- 4325916 TI - Tachyphylactic responses exhibited by phosphorylase 'a' activity levels in rat uteri. PMID- 4325917 TI - Natriuretic effects of vasopressin and cyclic AMP: possible site of action in the nephron. PMID- 4325919 TI - Aflatoxin biosynthesis in Aspergillus parasiticus: effect of methionine analogs. PMID- 4325918 TI - [Ultra-rapid cytodiagnosis in ambulatory dermatologic practice]. PMID- 4325921 TI - The growth and morphological changes of the genus Bordetella in rotated fluid glycine cultures. PMID- 4325920 TI - The metabolism of p-fluorophenylacetic acid by a Pseudomonas sp. I. Isolation and identification of intermediates in degradation. PMID- 4325922 TI - Stabilization of poliovirus to 32P decay. PMID- 4325923 TI - Anatomic and histologic changes of early emphysema. PMID- 4325924 TI - To brush or not to brush: is there really a question? Brush biopsy of the lung. PMID- 4325925 TI - [Water balance in the elasmobranchs: arguments in favor of endocrine control]. PMID- 4325926 TI - Development of the secretory capacity of the chick embryo adrenal glands. PMID- 4325927 TI - Comparison of two antimicrobial-corticoid preparations in the management of acute otitis externa. PMID- 4325928 TI - Appearance of virus particles in BALB-c mammary nodule outgrowth lines transplanted into BALB-c f. C3H and (C3Hf x BALB-c)F1 mice. PMID- 4325929 TI - Induction of tumor immunity in mice with antigens prepared from influenza and vesicular stomatitis virus grown in suspension culture of Ehrlich ascites cells. PMID- 4325930 TI - Isolation and characterization of a lymphatic leukemia virus in the Friend virus complex. PMID- 4325931 TI - Rapid assay of murine leukemia virus helper activity for Friend spleen focus forming virus. PMID- 4325932 TI - Cellular interactions in vitro with cells derived from tumors induced by murine sarcoma virus (Harvey). PMID- 4325933 TI - Production of antigens associated with Epstein-Barr virus in experimentally infected lymphoblastoid cell lines. PMID- 4325934 TI - Chromosome patterns in rat hepatocytes during N-2-fluorenylacetamide carcinogenesis. PMID- 4325935 TI - Nodule bioassay of the mouse mammary tumor virus: modifications and quantitative considerations. PMID- 4325936 TI - Immunologic cross-reactivity between antigen of unfertilized mouse eggs and mouse cells transformed by simian virus 40. PMID- 4325937 TI - In vitro production of murine leukemia virus by cells differing in a single allele. PMID- 4325938 TI - Spontaneous cancers in Praomys (Mastomys) natalesnis. PMID- 4325939 TI - Search for group-specific antibodies of avian leukosis virus in human leukemic sera. PMID- 4325940 TI - Benign mixed tumor of buccal salivary gland. PMID- 4325941 TI - Wilms' tumor. II. Diagnosis and treatment. PMID- 4325942 TI - [Case report of a synovial sarcoma of the forearm]. PMID- 4325943 TI - [The modalities of necrosis of the invading trophoblast under the influence of androgenic hormones in a case of chorioadenoma destruens with metastases and a case of chorioepithelioma treated with testosterone]. PMID- 4325944 TI - [Physico-chemical characteristics of true and presumed neurochemical transmitters]. PMID- 4325945 TI - Studies on the site of action of o,p'-DDD in the dog adrenal cortex. 1. Inhibition of ACTH-mediated pregnenolone synthesis. PMID- 4325946 TI - The microscopical anatomy of the bladder wall of Cysticercus bovis at the electron microscope level. PMID- 4325947 TI - [Intrahepatic infection experiments in golden hamsters with E. histolytica Crithidia cultures with and without the use of bacteria]. PMID- 4325948 TI - [Intranuclear inclusions in endocrine cells of the rabbit stomach]. PMID- 4325950 TI - Experimental studies on trauma and metastasis formation. PMID- 4325949 TI - [The ultrastructure of the median eye and ventral frontal organ of Artemia salina L. (Crustacea:Anostraca)]. PMID- 4325951 TI - The effect of corticotrophin on the rat uterine weight response to human chorionic gonadotrophin. PMID- 4325952 TI - Peptidyl peptide hydrolases, cathepsin and collagenase (?) of the rat uterus during postpartum involution. PMID- 4325954 TI - Increase in thyroid uptake of radioiodine induced by actinomycin D. PMID- 4325953 TI - [Enzymologic studies in arrhenoblastoma]. PMID- 4325955 TI - Polyneuropathies of undetermined cause. PMID- 4325956 TI - Antibiotic sensitivity testing. Report of an international collaborative study. PMID- 4325957 TI - Sleep and sleep mechanisms. PMID- 4325958 TI - The present state of the second messenger theory. PMID- 4325959 TI - Metabolic and circulatory effects of theophylline in canine subcutaneous adipose tissue. PMID- 4325961 TI - Specific determination of labelled cyclic 3'5'-AMP. PMID- 4325960 TI - Effects of dibutyryl-3',5'-AMP on the isolated working rat heart. PMID- 4325962 TI - The blood pressure effect of angiotensin in nephrectomized rats. PMID- 4325963 TI - The role of cyclic 3'5'-AMP in the cardiac response to adrenaline. PMID- 4325964 TI - [Chemodectoma of the tongue: differential diagnostic and histogenetic criteria]. PMID- 4325965 TI - [Cylindromas of the mouth]. PMID- 4325966 TI - [Dental age]. PMID- 4325967 TI - [Seasonal morphological and biochemical changes in the liver of Rana esculenta]. PMID- 4325968 TI - Primary carcinoma of the liver complicating cirrhosis. PMID- 4325969 TI - Radioimmunoelectrophoretic identification of poliovirus inhibitors and their characteristic mode of action. PMID- 4325970 TI - Further biochemical testing of feline picornaviruses. PMID- 4325971 TI - Foot-and-mouth disease virus in cattle and pigs: use of polyethylene glycol or dextran for purifying 19S gamma-M immunoglobulin from sera. PMID- 4325972 TI - Two different complement fixing antigens found in the Burkitt lymphoma cell cultures. Brief report. PMID- 4325973 TI - Serologic differentiation of human cytomegalovirus strains using rabbit hyperimmune sera. Brief report. PMID- 4325974 TI - Natural immunity of Ghanaian children to polio and coxsackieviruses. Brief report. PMID- 4325975 TI - Immunofluorescent studies on the effect of antiviral substances on virus multiplication. II. Determination of fluorescence intensity in Mengo virus infected L cells treated with beta-2-DL-thienylalanine. PMID- 4325976 TI - Immunofluorescent studies on the effect of antiviral substances on virus multiplication. 3. Effect of actidione on the multiplication of Mengo virus. PMID- 4325977 TI - Studies on the distribution of polioviruses in Surinam. PMID- 4325978 TI - [Studies of the antigenic components of Coxsackie and ECHO viruses and their antibodies]. PMID- 4325979 TI - The formation of interferon during acute respiratory virus infection of volunteers. PMID- 4325980 TI - Conidiation in Neurospora crassa. PMID- 4325981 TI - [Chemotherapy of tuberculosis]. PMID- 4325982 TI - [Crystalloid inclusions in the granula of eosinophilic granulocytes: electron microscopic study on leukocytes of Nandu blood]. PMID- 4325983 TI - [Type A Clostridium perfringens enterotoxemia in pheasant-farming. Etiological comments]. PMID- 4325984 TI - The thermoprofile as an early indicator of breast cancer response to hormonal therapy. PMID- 4325985 TI - Adenoid cystic carcinoma of the uterine cervix. Report of 4 cases. PMID- 4325986 TI - Salivary gland tumors in the parotid gland, submandibular gland, and the palate region. PMID- 4325987 TI - Electron microscopic study of papillary serous tumors of the ovary. PMID- 4325988 TI - Multiple primary tumors including bilateral breast cancers in a man with Klinefelter's syndrome. PMID- 4325989 TI - Fine structure of the Brenner tumor. PMID- 4325990 TI - Recurrent digital fibromas of childhood. An electron microscope study. PMID- 4325991 TI - [Clinical and genetic aspects of Poland's syndrome]. PMID- 4325992 TI - [The ACTH test in normal and pathological early and late pregnancy]. PMID- 4325993 TI - What is the mechanism of vasopressin in causing corticotropin release? PMID- 4325994 TI - [Thyroid peroxidase insufficiency as factor in the etiopathogenesis of endemic and sporadic goiter]. PMID- 4325995 TI - [Ovulation inhibitors and ACTH reserve]. PMID- 4325996 TI - [On the use of a new technic for demonstration of plaques formed by poliomyelitis viruses]. PMID- 4325997 TI - [2 cases of skin metastasis from epithelial tumors of unknown site. (Clinico histological contribution)]. PMID- 4326000 TI - Immune reactions in mucous membranes. II. The differentiation of intestinal mast cells during helminth expulsion in the rat. PMID- 4325998 TI - [Cells and aging]. PMID- 4325999 TI - Metabolism of 25-hydroxycholecalciferol in nephrectomized rats. PMID- 4326001 TI - Immune reactions in mucous membranes. 3. The discharge of intestinal mast cells during helminth expulsion in the rat. PMID- 4326002 TI - Tumour viruses: fixing transformation. PMID- 4326003 TI - Acid phosphatase activity in the small granules of epithelial cells in normal human oral mucosa. PMID- 4326005 TI - [Therapy of chronic polyarthritis in the practice]. PMID- 4326004 TI - Influence of physical training, aortic constriction and exogenous anterior pituitary hormones on the heart weights of hypophysectomized rats. PMID- 4326006 TI - [Alternating corticotherapy of long duration (personal technic)]. PMID- 4326007 TI - [Comparative studies on the effect of free and conjugated estrogens on the lipid metabolism in ovarectomized rats]. PMID- 4326008 TI - The influence of depot-beta 1-24-tetracosactide and of metyrapone on the excretion of free urinary cortisol in infants. PMID- 4326009 TI - [Placental transmission of cytomegalovirus CF-antibodies]. PMID- 4326010 TI - [Change in the resistance of mice to virus infection (foot-and-mouth-disease virus) after pretreatment with urethane]. PMID- 4326011 TI - [Interferon production stimulation in the white mouse by dimethylsulfoxide (DMSO)]. PMID- 4326012 TI - Factors affecting the reactivity of the activated SH-group of D-glyceraldehyde 3 phosphate dehydrogenase. PMID- 4326013 TI - The use of diethyl pyrocarbonate as a nuclease inhibitor in the extraction of ribonucleic acids from animal tissues. PMID- 4326014 TI - [Correlations between protein synthesis and serotonin in various activities of the central nervous system. (Slow and desynchronized sleep, learning and memory, sexual activity, morphine tolerance, aggressivity, Na gammahydroxybutyrate pharmacology]. PMID- 4326015 TI - Estrogen synthesis in castrated women: the action of human chorionic gonadotropin and corticotropin. PMID- 4326016 TI - Seven-hour radioimmunoassay of human chorionic gonadotropin. PMID- 4326017 TI - Comparative study of the antibody response in amebiasis. Persistence after successful treatment. PMID- 4326018 TI - Fine structure of the Leydig cell during postnatal differentiation of the mouse testis. PMID- 4326019 TI - Lysosomes and the toxicity of particulate pollutants. PMID- 4326020 TI - Reaction of nitrogen dioxide with blood and lung components. Electron spin resonance studies. PMID- 4326022 TI - Cholangiocarcinoma and operative cholangiography. PMID- 4326023 TI - Neurogenous neoplasms of major nerves of face and neck. PMID- 4326024 TI - Some psychoanalytic research into the communication of meaning through language: the quality and magnitude of psychological states. PMID- 4326021 TI - A theory on heart rate control by muscular metabolic receptors. PMID- 4326025 TI - Quantum theory of nerve excitation. PMID- 4326026 TI - Pox in South American sea lions (Otaria byronia). PMID- 4326027 TI - Effect of angiotensin on noradrenaline-3H accumulation and synthesis in vivo. PMID- 4326028 TI - Effects of single cortisone injections on brown adipose tissue of developing rats. PMID- 4326030 TI - Inhibition by oxytetracycline of the development of the enhanced response to noradrenaline in cold-acclimated rats: a new approach to the study of nonshivering thermogenesis. PMID- 4326029 TI - Effect of phenylephrine on cardiac contractility and adenyl cyclase activity. PMID- 4326031 TI - Site of action of angiotensin and other vasoconstrictors on the kidney. PMID- 4326032 TI - Enzyme patterns in a group of transplantable mouse hepatomas of different growth rates. PMID- 4326033 TI - Light microscopic observations of Morris hepatomas. PMID- 4326034 TI - Transfer RNA methylase activity in normal rat liver and some Morris hepatomas. PMID- 4326036 TI - Inhibition of migration of human autogenous and allogeneic leukocytes by extracts of patients' cancers. PMID- 4326035 TI - Activation of the carcinogen, N-hydroxy-2-fluorenylbenzene-sulfonamide, by desulfonylation to N-2-fluorenylhydroxylamine in vivo. PMID- 4326037 TI - Host response in spontaneous regression of murine leukemia. PMID- 4326038 TI - Regression of prolactin-dependent rat mammary carcinoma in response to antihormone treatment. PMID- 4326040 TI - Tumor-specific immunity in the course of primary polyoma and Rous tumor development in intact and immunosuppressed rats. PMID- 4326041 TI - Heart-rate variability in sleep and wakefulness. PMID- 4326039 TI - Cell proliferation and tumor growth in hepatomas 3924A. PMID- 4326042 TI - Evolution of sex-chromosomes and formation of W-chromatin in snakes. PMID- 4326043 TI - Lung tumors of primates and rodents. II. PMID- 4326044 TI - Electrophysiological study of nerve injuries in workers handling acrylamide. PMID- 4326045 TI - Acetylcholine mimics crossed olivocochlear bundle stimulation. PMID- 4326046 TI - Effect of norepinephrine, histamine and other drugs on cyclic 3',5'-AMP formation in brain slices of various animal species. PMID- 4326048 TI - [Alpha-fetoprotein in the diagnosis of primary liver neoplasms]. PMID- 4326047 TI - [Rehabilitation after injury to peripheral nerves]. PMID- 4326050 TI - [Neonatal icterus due to hepatic immaturity]. PMID- 4326049 TI - [Renovascular hypertension. I. Comparison of the different examinations and tests for detection. Superiority of intravenous urography]. PMID- 4326051 TI - [Virologic and serologic survey of poliomyelitis carried out in 1969 after revaccination]. PMID- 4326052 TI - [Clinical characterization of poliomyelitis cases in Poland in 1968]. PMID- 4326053 TI - [Progress in the diagnosis of functional changes in the peripheral nerves]. PMID- 4326054 TI - [Precocious puberty of ovarian origin]. PMID- 4326055 TI - [Evolutive chronic polyarthritis with dissociated serology]. PMID- 4326056 TI - [Definition, limitation, psychopathology and classification of non-dissociative chronic delire]. PMID- 4326057 TI - [Sedimentation rate higher than 100 mm in the first hour. Study of a series of 150 cases]. PMID- 4326058 TI - [Non-surgical therapy of coxarthrosis]. PMID- 4326059 TI - [A case of transitory agranulocytosis due to thiamphenicol]. PMID- 4326060 TI - [Studies on nucleotide metabolism in the isolated perfused guinea pig heart under irradiation]. PMID- 4326061 TI - Experience with hepatic arterial infusions. PMID- 4326062 TI - [Problems in the classification of testicular tumors with special reference to the classification by Collins & Pugh]. PMID- 4326063 TI - [Ultrastructural comparison of human parathyroid glands in secondary hyperparathyroidism and primary parathyroid adenoma]. PMID- 4326064 TI - [Cytoplasmic vacuoles in human anterior horn cells in tetanus]. PMID- 4326065 TI - Ultrastructural organization and RNA labelling of hepatic ribosomes in rats fed on diets deficient in essential amino acids. PMID- 4326066 TI - Glycogenesis type I (glucose 6-phosphatase deficiency): ultrastructural alterations of hepatocytes in a tumor bearing liver. PMID- 4326067 TI - [Cytology of the prenatal development of human gonads. II. Electronmicroscopic studies on the cytogenesis of gonocytes and foetal spermatogonia in the testis]. PMID- 4326069 TI - A study of complement-fixing, immunofluorescent, and neutralizing antibodies in human cytomegalovirus infections. PMID- 4326068 TI - The recurrent collaterals of Purkinje cell axons: a correlated study of the rat's cerebellar cortex with electron microscopy and the Golgi method. PMID- 4326070 TI - The cell types in the adenohypophysis of the cichlid fish Cichlasoma biocellatum Regan, with special attention to its osmoregulatory role. PMID- 4326071 TI - Effect of ACTH on mitochondrial RNA synthesis of rat adrenocortical cells. PMID- 4326072 TI - Endocrine cells of the human gastric mucosa. PMID- 4326073 TI - [On bladder neoplasms in dogs]. PMID- 4326074 TI - [Changes in local and systemic parameters in the rat exposed to an inflammatory process. I]. PMID- 4326075 TI - [Modulation of lemniscal transmission during voluntary movement]. PMID- 4326076 TI - [Polezhaev's method for determining quartz in the presence of silicates]. PMID- 4326077 TI - [Fetal radiological age. Its clinical utility]. PMID- 4326078 TI - The treatment of toxoplasmic uveitis. PMID- 4326079 TI - [Enzymological study of carbohydrate metabolism regulation during pregnancy from the standpoint of maternal-fetal relationship]. PMID- 4326080 TI - Co-operative binding of nicotinamide-adenine dinucleotide to yeast glyceraldehyde 3-phosphate dehydrogenase. I. Equilibrium and temperature-jump studies at pH 8-5 and 40 degrees C. PMID- 4326081 TI - Co-operative binding of nicotinamide-adenine dinucleotide to yeast glyceraldehyde 3-phosphate dehydrogenase. II. Stopped-flow studies at pH 8-5 and 40 degrees C. PMID- 4326082 TI - Primary malignant tumors of the liver in children. PMID- 4326083 TI - The role of "total" pancreatectomy in the treatment of unremitting hypoglycemia of infancy. PMID- 4326084 TI - Serum ionic calcium: changes with large volume blood transfusions in the infant. PMID- 4326085 TI - [Various aspects of the physiological action of angiotensin]. PMID- 4326086 TI - Segmental demyelination secondary to axonal degeneration in uremic neuropathy. PMID- 4326087 TI - [Daily rhythm of the plasma corticosteroid concentration and reactivity of the central nervous system, anterior lobe of the pituitary gland and adrenal cortex in swine]. PMID- 4326088 TI - Effects of systemic and intracerebral administration of two opposite acting ACTH related peptides on extinction of conditioned avoidance behavior. PMID- 4326089 TI - [A social psychiatric evaluation of 732 after care patients]. PMID- 4326090 TI - [Trophoblastic disease in the Hospital San Juan de Dios, Cucuta]. PMID- 4326091 TI - Tropical disease and general medicine. PMID- 4326092 TI - [Results of long-term medical treatment of hypertension. 200 patients followed-up for 5 years]. PMID- 4326093 TI - [Apropos of certain toxic effects of L-asparaginase in human therapy]. PMID- 4326094 TI - [Autoperfusion of ascitic fluid in cirrhosis. Effects on elimination of water, sodium and potassium]. PMID- 4326095 TI - [Catecholamines in obesity]. PMID- 4326096 TI - [Chemotherapy of solid tumors. Epitheliomas and sarcomas of non-hematopoietic organs]. PMID- 4326097 TI - Respiratory paralysis secondary to the use of polymyxin B. PMID- 4326098 TI - Geographical distribution of Burkitt's lymphoma in the Democratic Republic of the Congo. PMID- 4326099 TI - [Diabetes mellitus. VII. Pharmacodynamics of insulin]. PMID- 4326100 TI - Placental reaction to the infectious bovine rhinotracheitis-infectious pustular vulvovaginitis virus. PMID- 4326102 TI - [Tumor of the trigeminal nerve as the cause of secondary neuralgia]. PMID- 4326101 TI - Thirst--and brain control of water balance. PMID- 4326103 TI - Correctable complications of neoplastic disease. II. Meningeal leukemia. PMID- 4326104 TI - [Sialic acid and ganglioside content of some tumors]. PMID- 4326105 TI - [Interaction of iminoxyl spin-label with the electron transport system in mitochondria]. PMID- 4326106 TI - The role of corticotrophin in promoting growth hormone release in man. PMID- 4326107 TI - [Effect of angiotensin II on the insulin production and plasma level of NEFA]. PMID- 4326108 TI - Virulence of strains of Entamoeba histolytica to rats and the effect of cholesterol, rat caecal and hamster liver passage on the virulence of non invasive strains. PMID- 4326109 TI - [Characteristics of template syntheses in myxoviruses]. PMID- 4326110 TI - Biochemical and physiological properties of methionyl-sRNA synthetase mutants of Salmonella typhimurium. PMID- 4326111 TI - Degradation of adsorbed transforming DNA by haemophilus influenzae. PMID- 4326112 TI - Esterases and phosphatases of Escherichia coli serotypes isolated from the pig. PMID- 4326113 TI - Comparison of the morphology, fermentation, assimilation, lipid content and mannans of rough and smooth strains of Saccharomyces cerevisiae. PMID- 4326114 TI - Subcellular fractionation of Tetrahymena pyriformis ST by zonal centrifugation: changes in activities and distribution of enzymes during the growth cycle and on starvation. PMID- 4326115 TI - Chemotherapy in the treatment of Wilms' tumor. PMID- 4326116 TI - Role of the renin-angiotensin system in pathogenesis of experimental renal hypertension. PMID- 4326117 TI - Significance of the renin-angiotensin system on the development of hypertension and the maintenance of elevated blood pressure levels. PMID- 4326118 TI - Interaction of angiotensin and noradrenaline in rat's hindlimb preparation. A possible mechanism of the experimental renal hypertension. PMID- 4326119 TI - On the role of aldosterone to hypertension, especially an extent of its participation. PMID- 4326120 TI - The role of aldosterone in pathogenesis of arterial hypertension. PMID- 4326121 TI - Discussion on pathogenesis of hypertension. PMID- 4326122 TI - 2',3'-cyclic nucleotide 3'-phosphohydrolase in purified myelin from brain of Jimpy and normal young mice. PMID- 4326123 TI - Catecholamine-sensitive adenyl cyclase in cell-free preparations from rat cerebral cortex. PMID- 4326125 TI - Glomangioma (glomus tumor): report of case with 50-year history. PMID- 4326124 TI - Inhibition of cyclic 3',5'-nucleotide phosphodiesterase by adenine compounds. PMID- 4326126 TI - [Unilateral transplantation of the distal portion of the femur to the reverse side in the segmental resection of the proximal part of the tibia and fibula]. PMID- 4326127 TI - Variation in immunosensitivity of SV40-transformed hamster cells. PMID- 4326128 TI - Interactions of xanthine derivatives, catecholamines and glucose-6-phosphate on the isolated phrenic nerve diaphragm preparation of the rat. PMID- 4326129 TI - Complement fixation in conventional and regressing virus-induced murine leukemia. PMID- 4326130 TI - Enzymes produced by a Pseudomonas species which inactivate inhibitors of certain viral hemagglutinins. II. Effect of a proteinase and phospholipase C on viral hemagglutinin inhibitors present in human sera. PMID- 4326131 TI - Serum allotype loss due to a lymphoid tumor in chickens. PMID- 4326132 TI - EEG and autonomic response pattern during waking and sleep stages. PMID- 4326133 TI - [Renal tumor with metastases]. PMID- 4326134 TI - Significance of collagenases from healing mammalian wounds. PMID- 4326135 TI - [Cytochemical study of some lysosomial hydrolases in thermo-adaptable strains of E. histolytica as compared with other strains of E. histolytica (37 degrees C), E. invadens and E. moshkovskii]. PMID- 4326138 TI - [The effect of microbial toxins on the permeability of the blood-tissue barrier]. PMID- 4326136 TI - [Biochemical, morphological and functional disturbances of the higher nervous centers in rabbits with experimental parodontitis induced by irrigation of the dental pulp with tricresolformaline and eugenol]. PMID- 4326137 TI - [Serological studies of immunization against equine herpesvirus abortion (rhinopneumonitis)]. PMID- 4326139 TI - [The mechanism of monochloramine action on bacteria. I. Submicroscopic changes in staphylococcal and Escherichia coli cells under the influence of monochloramine]. PMID- 4326140 TI - The ultrasonic scan in the management of amebic hepatic abscess. PMID- 4326141 TI - Transmission at the neuro-effector junction of the isolated myenteric plexus longitudinal muscle preparation of the guinea pig ileum. PMID- 4326143 TI - [Clinical and electromyographic study of lingual hemiatrophy]. PMID- 4326142 TI - Tracheobronchial secretions. PMID- 4326144 TI - Oesophageal manometric studies of dysphagia in Vernet's syndrome. PMID- 4326145 TI - [Tumors of chemoreceptors. Personal cases in dogs]. PMID- 4326147 TI - [Study by the spin probe method of ATP-dependent conformational transitions in mitochondrial membranes]. PMID- 4326146 TI - Effect of polyenic antibiotics on Ehrlich ascites and Novikoff hepatoma cells. PMID- 4326148 TI - [Use of 32 P labeled polioviruses, cultivated in different cell cultures, for chromatographic studies]. PMID- 4326149 TI - A radioimmunoassay for rat plasma ACTH. PMID- 4326150 TI - Guanyl cyclase activity in normal adrenals and a corticosterone producing adrenal cancer of the rat. PMID- 4326151 TI - Effects of cyclic 3',5'-AMP on metabolism of muscle fibers from adult and young rats. PMID- 4326152 TI - Functional electron microscopy of the hypothalamic median eminence. PMID- 4326153 TI - [Ectopic hormone synthesis]. PMID- 4326154 TI - Renal effects of adenosine 3',5'-cyclic monophosphate and dibutyryl adenosine 3',5'-cyclic monophosphate. Evidence for a role for adenosine 3',5'-cyclic monophosphate in the regulation of proximal tubular sodium reabsorption. AB - Stable water diuresis was produced in anesthetized, hydrocortisone-treated hypophysectomized dogs by infusion of 2.5% dextrose. Infusion of adenosine 3',5' cyclic monophosphate (cyclic AMP) in the left renal artery decreased ipsilaterally glomerular filtration rate (GFR), cortical and non-cortical renal plasma flow, and tended to increase urine flow (V) and free-water clearance (C(H2O)) despite a decrease in mean arterial pressure. Infusion of dibutyryl adenosine 3',5'-cyclic monophosphate (dibutyryl cyclic AMP) in the left renal artery increased V and C(H2O) significantly (P<0.01) bilaterally with essentially no change in GFR, in total renal plasma flow or its cortical and non-cortical components. For each kidney the magnitude of the change in V was similar to the magnitude of the change in C(H2O) and the change in sodium excretion was trivial. Cyclic AMP probably produced its effects on renal hemodynamics and mean arterial pressure wholly or in part through the action of metabolites such as 5'-AMP and adenosine on the renal and systemic vasculature. The absence of an effect of dibutyryl cyclic AMP on renal hemodynamics and its bilateral effect may be explained by the resistance of this nucleotide derivative to metabolism. Dibutyryl cyclic AMP appears to decrease by direct cellular effect(s) proximal tubular sodium reabsorption but does not prevent virtually complete reabsorption of the increased load of sodium in the distal nephron. This effect on the kidney is qualitatively and quantitatively similar to the effect of renal arterial infusion of isoproterenol. The results suggest that synthesis of cyclic AMP in proximal renal tubule cells in response to stimulation of beta adrenergic or other receptors can mediate a decrease in the proximal tubular reabsorption of sodium. PMID- 4326155 TI - Effects of salinity, hypophysectomy and corticotrophin or branchial Na- and K activated ATPase in the eel, Anguilla anguilla L. PMID- 4326156 TI - Lactogenesis in pseudopregnant rabbits treated with adrenocorticotrophin and adrenal corticosteroids. PMID- 4326157 TI - The intracellular and intramitochondrial distribution of short-chain acyl-CoA synthetases in guinea-pig heart. PMID- 4326158 TI - [Calcitonin]. PMID- 4326159 TI - A new nucleotidase of rat liver with activity toward 3'-and 5'-nucleotides. PMID- 4326160 TI - Nucleoside triphosphate phosphotransferase. A new enzyme activity of oncogenic and non-oncogenic "budding" viruses. PMID- 4326161 TI - Chloroplast and cytoplasmic enzymes. 3. Pea leaf ribose 5-phosphate isomerases. PMID- 4326163 TI - Myeloperoxidase of the leukocyte of normal blood. II. The oxidation-reduction reaction mechanism of the myeloperoxidase system. PMID- 4326162 TI - The binding of NAD+ to rabbit muscle glyceraldehyde-3-phosphate dehydrogenase studied by protein fluorescence quenching. PMID- 4326165 TI - Abuse of communication--and being understood. PMID- 4326164 TI - Purine nucleoside phosphorylase of chicken liver. PMID- 4326166 TI - [Infectious mononucleosis: two studies of serum antibodies against Epstein-Barr virus]. PMID- 4326167 TI - [Effect of 9-alpha-fluorocortisol on adrenocortical function]. PMID- 4326168 TI - Reflections on latent viruses--a new definition of an infectious agent. PMID- 4326169 TI - Molecular consequences of ethidium bromide mutagenesis. PMID- 4326170 TI - Mass action-type direct feedback control of pituitary release. PMID- 4326171 TI - [Reovirus in pediatric pathology]. PMID- 4326172 TI - Long-term steroid-immunosuppressive treatment of the childhood nephrotic syndrome. PMID- 4326174 TI - Pancreatic islet cell tumors produced by the combined action of streptozotocin and nicotinamide. PMID- 4326176 TI - [Quantitative study of ocular movements in paradoxical sleep: clinical value]. PMID- 4326175 TI - [Origin and development of optical activity of bio-organic compounds]. PMID- 4326178 TI - [The floppy infant syndrome]. PMID- 4326179 TI - [Myasthenia gravis. Immunosuppressive treatment]. PMID- 4326177 TI - [Carcinomatous myopathies and the myasthenic syndrome]. PMID- 4326180 TI - [New route of regulating folic acid metabolism in experimental chemotherapy of leukoses and malignant neoplasms]. PMID- 4326181 TI - Myocarditis in round heart disease of turkeys. A light and electron microscopic study. PMID- 4326183 TI - [Prognostic importance of ante- and perinatal factors for later development of the child]. PMID- 4326173 TI - Infectious diseases: annual review of significant publications. PMID- 4326182 TI - The ultrastructure of primary hepatocellular cancer in man. PMID- 4326184 TI - [Prevention of recurrence in urolithiasis]. PMID- 4326185 TI - [Permanent virus excretors in cattle vaccinated and experimentally infected with foot-and-mouth (FM) disease]. PMID- 4326188 TI - [Studies on the determination of proliferation dosage of conjugated estrogens]. PMID- 4326186 TI - [Further studies on delayed type foot-and-mouth disease allergy]. PMID- 4326189 TI - [Conduction of vaginal tissue during therapy with newer estrogens]. PMID- 4326187 TI - Chemical composition of the coal miner's lung. PMID- 4326190 TI - [Studies on the use of a new sequential therapy in premenopause]. PMID- 4326191 TI - [Effects of hyper- and hypothyreosis on enzyme patterns in the rat ovary]. PMID- 4326192 TI - [Histochemistry of unspecific phosphatases in ovarian carcinoma and their relation to the clinical picture]. PMID- 4326193 TI - [Behavior of unspecific acid and alkaline phosphatases in ovarian carcinoma before and during therapy with Endoxan]. PMID- 4326194 TI - [Value of influencing the lymphatic circulation by drugs in gynecologic lymphography]. PMID- 4326195 TI - [Limits of morphological diagnosis of malignant epitheliomas; possibilities for their overcoming as shown on the example of breast carcinomas]. PMID- 4326196 TI - [Therapeutic results in breast carcinoma with reference to histological classification]. PMID- 4326197 TI - [Roentgen diagnosis of the secreting breast]. PMID- 4326198 TI - [Embryonal and fetal virus diseases]. PMID- 4326199 TI - Virus antibodies and multiple sclerosis. PMID- 4326200 TI - Electroencephalogram and sensory evoked potentials. Findings in an unresponsive patient with pontine infarct. PMID- 4326201 TI - Sleep and dream studies in obsessional neurosis with particular reference to epileptic states. PMID- 4326202 TI - Time estimation during sleep. PMID- 4326203 TI - [Characteristics of the initial cortisolemic response after impulsive stimulation with synthetic beta-1-24 corticotropin]. PMID- 4326204 TI - Adenoid cystic carcinoma of the mandible. PMID- 4326206 TI - The evolution of different types of myoclonus during sleep. A polygraphic study. PMID- 4326205 TI - Approaches to a biological basis of human behavior. PMID- 4326207 TI - Metabolic interrelationships among phospholipids. PMID- 4326208 TI - Acid phosphatase and deoxyribonucleic acid studies in D.M.B.A. induced experimental oral carcinogenesis in hamster cheek pouch. PMID- 4326209 TI - Interactions among sites responsible for trehalose 6-phosphate and trehalose activated glucose 6-phosphate hydrolysis on trehalose phosphatase isolated from Phormia regina. PMID- 4326210 TI - Electromagnetic properties of hemoproteins. IV. Single crystal electron paramagnetic resonance spectroscopy of hemoproteins at ambient temperature. PMID- 4326211 TI - The metabolism of glyceride glycolipids. V. Identification of the membrane lipid formed from diglucosyl diglyceride in Streptococcus faecalis ATCC 9790 as an acylated derivative of glyceryl phosphoryl diglucosyl glycerol. PMID- 4326212 TI - Adenosine diphosphate ribosylation of aminoacyl transferase II and inhibition of protein synthesis by diphtheria toxin. PMID- 4326213 TI - Isolation of glucosylceramides from yeast (Hansenula ciferri). PMID- 4326214 TI - Glyceraldehyde phosphate dehydrogenase of Escherichia coli. Structural and catalytic properties. PMID- 4326215 TI - Inhibition of nicotinamidase by nicotinamide adenine dinucleotide. PMID- 4326216 TI - Effect of urea on the divalent cation binding site of pyruvate kinase. PMID- 4326217 TI - The effect of hypophysectomy, and of injections of thyrotrophin and corticotrophin into hypophysectomized animals, on the sloughing cycle of the lizard, Gekko gecko L. PMID- 4326218 TI - Distribution of (131-I)alpha-1-24adrenocorticotrophin in the intact guinea-pig. PMID- 4326219 TI - Congenital adrenal hyperplasia and other conditions associated with a raised urinary steroid 11-oxygenation index. PMID- 4326220 TI - Hormonal regulation of RNA and protein synthesis in the mouse mammary gland before and during lactation. PMID- 4326221 TI - The effects of corticotrophin, glucose and potassium chloride on secretion by the nasal salt gland of the duck, Anas platyrhynchos. PMID- 4326223 TI - Pharmacology of the Malpighian tubules of Rhodnius and Carausius: the structure activity relationship of tryptamine analogues and the role of cyclic AMP. PMID- 4326222 TI - The pharmacology of efferent synapses in the lateral-line system of Xenopus laevis. PMID- 4326224 TI - Fibromyoma of posterior end of inferior turbinal. PMID- 4326225 TI - An unusual pharyngeal tumour. PMID- 4326226 TI - Nature of lysosomal angiotensinase activity. PMID- 4326227 TI - Regulating the expression of malignancy. PMID- 4326228 TI - Ciromosomal control of reversion in transformed cells. PMID- 4326229 TI - [Virology and its importance for water hygiene]. PMID- 4326230 TI - Effects of estrogenic therapy on the breast. PMID- 4326231 TI - [Unexpected cases. Outpatient treatment series. 20]. PMID- 4326232 TI - A kinetic method for determination of plasma renin activity using radioassay of Angiotensin I. PMID- 4326233 TI - [Nephroblastoma. Chromosomal study]. PMID- 4326234 TI - [Histoenzymology of severe hepatitis]. PMID- 4326235 TI - [Ewing type reticular sarcoma of bone marrow. Optic, histochemical and electron study of 2 cases]. PMID- 4326237 TI - Substrate stabilization: genetically-controlled reciprocal relationship between two enzymes. PMID- 4326238 TI - Synovial effusion induced by adrenocorticotrophic hormone. PMID- 4326236 TI - Serological investigations for evidence of an infectious aetiology of rheumatoid arthritis. PMID- 4326239 TI - Amoebiasis of the cervix uteri. PMID- 4326240 TI - Value of electromyography in lumbar radiculopathy. PMID- 4326241 TI - [1st case of meningeal cryptococcosis on the Ivory Coast]. PMID- 4326242 TI - [Treatment of symptomatic intestinal amebiasis by metronidazole in an Upper Volta hospital]. PMID- 4326244 TI - [Lipid bioantioxidants in animal visceral tissues in relation to the degree of unsaturation of exogenous lipids]. PMID- 4326243 TI - [50 cases of primary cancer of the liver and their geographic distribution]. PMID- 4326245 TI - [New etiological aspects of exanthema in horses and cattle]. PMID- 4326246 TI - Radiologic survey in the Solomon Islands, 1968: lungs, heart, spleen, scoliosis, bone age, and dental development. PMID- 4326247 TI - The hygiene and marketing of fresh cream as assessed by the methylene blue test. A report by a Working Party to the Director of the Public Health Laboratory Service. AB - The hygiene and marketing of fresh cream in England and Wales was investigated by a working party of the Public Health Laboratory Service (PHLS) between 1 October 1968 and 31 July 1969. Thirty-one cream-producing dairies were visited and observations made in the light of the Code of Practice published by the Milk and Milk Products Technical Advisory Committee of the Ministry of Agriculture, Fisheries and Food, and the Scottish Home and Health Department. Suggestions are made in this report to strengthen the code.A total of 5184 samples of fresh cream comprising 4385 heat-treated, 282 clotted and 517 untreated were examined. Details of production, age of the cream, distance and mode of distribution along the retail chain were available for most samples, and this history was, as far as possible, related to the laboratory findings. In the laboratory the samples were examined by the methylene blue test, colony count, coliform and Escherichia coli I test and for pathogens. Staphylococcus aureus was grown from 59 out of 3417 samples of cream; 54 of these were from untreated cream. Phage typing indicated that a proportion of these strains were of animal, presumably bovine, origin. Other human pathogens isolated included one each of Salmonella typhimurium, Brucella abortus, E. coli type O126 and Clostridium welchii.It appeared that heat treated cream was much better, bacteriologically, than untreated; and that large dairies, in general, had better premises, more hygienic methods of preparation and the advantages of mechanical filling and capping of cartons; thus they offered the consumer a better product, bacteriologically, than some of the smaller dairies.A statistical analysis of the results of the tests used showed the methylene blue test, in spite of some anomalies, to be of more use as a screening test than any of the others. As this test is cheap and easy to carry out, the working party thought that it should be the test of choice. In view of the known anomalies, however, the working party recommends that the test should remain a screening or advisory test and have no penal function. Results should be reported as follows: cream not decolorizing the dye in 4 hr. at 37 degrees C. (+/ 0.5 degrees ) after overnight incubation at 20 degrees C. (+/- 0.5 degrees ) would be accepted as satisfactory; between (1/2) and 4 hr. at 37 degrees C. (+/- 0.5 degrees ) as fairly satisfactory; but if the dye were decolorized at the end of the overnight incubation the sample would be provisionally classified as ;unsatisfactory; requires further investigation'. A repeat sample would then be examined. If samples were repeatedly unsatisfactory, consultations would be arranged between the local authority, the laboratory and the dairy, with perhaps inspection of the dairy premises and retail storage conditions and further, more searching tests on samples made in an effort to eradicate production faults. PMID- 4326248 TI - Investigations of Allerton-type herpes virus infection in East African game animals and cattle. AB - Neutralization tests with a strain (BA) of Allerton-type herpes virus, derived from a buffalo (Syncerus caffer) were carried out on 924 sera from 17 species of E. African game animals and on cattle sera from Tanzania (2001), Kenya (792) and Uganda (410).Buffalo populations throughout E. Africa showed a very high rate of infection, with all animals over 2 years of age serologically positive. Antibody was present in some giraffe, waterbuck and hippopotamus sera and, less frequently, in impala, eland, bushbuck and oryx. Data are provided on the titres of positive samples; the mean titre of buffalo sera increased with age.Cattle in many localities of N. Tanzania and S. Kenya showed a very high rate of infection, 85-95% of sera from animals more than 2-years old containing antibody; the titres recorded were lower than those in buffaloes. Very high infection rates were also found in Karamoja and Teso (Uganda) and also in some other areas of Kenya, whilst a considerably lower incidence of infection was detected in W. Nile Province of Uganda and in central Tanzania. Differences in infection rates may have been related to herd size and husbandry practices.It was shown that a wave of infection was probably spreading through cattle in N. Tanzania at about the same time as an outbreak of disease occurred in buffaloes and it is suggested that virus transmission may have been by biting flies.No clinical signs attributable to the virus were reported in cattle but mouth lesions similar to those recorded in buffaloes, or nasal lesions, could have passed undetected. Allerton-type virus probably produces a range of clinical syndromes in cattle, closely resembling those associated with some herpes viruses in primates but infection is seldom related in the field to either pseudo-lumpy skin disease, mammillitis or stomatitis. PMID- 4326249 TI - The growth and persistence of foot-and-mouth disease virus in the bovine mammary gland. AB - In animals exposed to foot-and-mouth disease virus by indirect contact, virus was recovered from the blood, milk, pharynx, vagina and rectum for variable periods of time before clinical disease was apparent. Virus instilled into the mammary gland multiplied rapidly and virus concentrations greater than 10(7) p.f.u./ml. were recorded within 8-32 hr., depending on the virus strain and dose inoculated. Virus multiplication was accompanied by clinical signs of mastitis but the classical signs of foot-and-mouth disease did not appear for 52-117 hr. Dissemination of virus from the mammary gland occurred within 4-24 hr. and in some animals samples taken from the pharynx, mouth, nose and vagina contained virus for periods up to 97 hr. before the appearance of vesicular lesions. Virus production in the udder declined with the appearance of virus neutralizing activity in the blood and the milk but persisted in some animals for periods of 3 7 weeks. The ability of foot-and-mouth disease virus to persist in mammary tissue was confirmed by the demonstration of virus multiplication in the udders of immune animals. PMID- 4326250 TI - Paraplegia: an aetiological survey. PMID- 4326251 TI - Water structure as a determinant of ion distribution in living tissue. PMID- 4326252 TI - Extragonadal testicular tumors. PMID- 4326253 TI - Epidemiologic aspects of postoperative sepsis in a urologic practice (with a note concerning antibacterial prophylaxis). PMID- 4326254 TI - [Transfer properties of the cat retina]. PMID- 4326255 TI - [A short adrenal cortex function test with a new synthetic ACTH analogue]. PMID- 4326257 TI - The cytomegaloviruses: ubiquitous agents with protean clinical manifestations. II. PMID- 4326258 TI - Therapeutic possibilities in Cushing's syndrome. PMID- 4326259 TI - Orchiectomy for trophoblastic tumors. PMID- 4326260 TI - Zoster-like disease in infants and young children. PMID- 4326256 TI - Results of treatment in 108 patients with Cushing's syndrome. PMID- 4326261 TI - [Changes in the alkaline phosphatase activity in circulating granulocytes under the effect of adrenal cortical stimulation]. PMID- 4326262 TI - [Peripheral vascular system in rheumatic fever in children]. PMID- 4326263 TI - [Disorders of perigliomatous neuroglia]. PMID- 4326264 TI - Endogenous losses of nutrients. PMID- 4326265 TI - Studies on calciferol metabolism. II. Tritium loss from tritiated vitamin D3 and the possible structure of the proposed nuclear regulator of intestinal calcium transport. PMID- 4326266 TI - Estradiol-17-beta and estrone: studies on their binding to rabbit uterine cytosol and their concentration in plasma. PMID- 4326267 TI - A radioimmunoassay for plasma progesterone. PMID- 4326268 TI - Structure of an estradiol-glutathione conjugate formed in the presence of peroxidase. PMID- 4326269 TI - A competitive protein binding method for the measurement of unconjugated and sulfate-conjugated dehydroepiandrosterone in peripheral plasma. PMID- 4326270 TI - [Effect of myxoviral enzymes on isolated polytene chromosomes]. PMID- 4326272 TI - [Series of transplantable mouse hepatomas]. PMID- 4326271 TI - [Acetylcholine activity in the myocardium]. PMID- 4326273 TI - Antiviral chemotherapy. PMID- 4326274 TI - [Fast postmortem diagnosis of adenovirus, para-influenza respiratory-syncytial virus diseases in children]. PMID- 4326275 TI - [Retransmission, to cattle, of a tumor of NMRI mice, presumably induced by bovine leukosis tissue]. PMID- 4326276 TI - The occurrence of virus-neutralizing antibodies to infectious bovine rhinotracheitis virus in sera from hippopotami and buffaloes. PMID- 4326277 TI - Studies on the duration of immunity conferred by a live-modified sheep pox tissue culture virus vaccine. PMID- 4326278 TI - Pancreas acinar cell regeneration. 8. Relationship of acid phosphatase and beta glucuronidase to intracellular organelles and ethionine lesions. PMID- 4326279 TI - Myositis ossificans progressiva (Munchmeyer's disease). Brief review with report of two cases treated with corticosteroids and observed for 16 years. PMID- 4326280 TI - Adrenocortical atrophy and diffuse cerebral sclerosis. PMID- 4326281 TI - Adrenal cortical function in asthmatic children on alternate day steroids. PMID- 4326282 TI - [Phosphatases, transaminases and aldolases in the synovial fluid in rheumatoid arthritis]. PMID- 4326283 TI - Viral crystalline arrays in FL cells infected with herpes simplex virus. PMID- 4326284 TI - The blood supply of chemodectomas of the head and neck: report of two cases. PMID- 4326285 TI - Transport of herpes simplex virus in Stuart's medium. PMID- 4326286 TI - Monitoring cerebral function: clinical experience with new device for continuous recording of electrical activity of brain. AB - A device, the cerebral function monitor, provides a continuous record of the electrical activity of the brain occurring at frequencies from 2 to 15 Hz. It is relatively cheap, portable, and easy to use and interpret. The apparatus has proved of value in three circumstances: firstly, when the cerebral circulation is likely to be vulnerable during open heart surgery; secondly, as a measure of recovery or deterioration following brain damage or drug overdose; and thirdly, where information about more physiological changes in cerebral function is required, for instance when testing anaesthetic and hypnotic drugs. PMID- 4326287 TI - Sleep of enuretics. PMID- 4326289 TI - Comprehensive department of psychological medicine: three-year review of inpatients referred for aftercare visits. AB - All inpatients discharged in 1967 from a comprehensive department of psychological medicine who were referred for aftercare visiting by a mental welfare officer or psychiatric social worker were reviewed after a period of three years. Over this period half the patients had not been readmitted and only 6.3% of those below retirement age had been unemployed for 75% or more of the total time involved. Altogether 76% were assessed as socially integrated, though there had been a drift away from living at home.It is probable that case conferences made the process of referral for aftercare more discriminating and that the follow up conferences contributed substantially towards the care, supervision, and maintenance of these patients in the community. Measures of this kind are essential if a general hospital psychiatric service is intended to cope with the total problem involved. PMID- 4326288 TI - Chronic fenfluramine administration: some cerebral effects. AB - Human cerebral function was monitored electrophysiologically during sleep over a period of months before, during, and after the intake of fenfluramine, 40-120 mg/day. Effects included dose-related reduction of paradoxical sleep, increase of intra-sleep restlessness, and changes in E.E.G. slow-wave sleep. It is hypothesized that weight loss may be associated with increase of the last. Grinding of teeth (bruxism) also was noted.Long-term studies make it possible to demonstrate changing central effects with time, including tolerance phenomena. Withdrawal abnormalities are related to the time taken for the drug to be eliminated-in the present case reaching a maximum four days after withdrawal. PMID- 4326290 TI - [Proteolytic enzyme activity of different sections of the rat brain during natural sleep and during paradoxical sleep deprivation]. PMID- 4326292 TI - Pathogenesis of amoebiasis. PMID- 4326293 TI - Investigation of antigenic relationship of Marek's disease, herpes virus and EB virus (herpes-type virus). PMID- 4326291 TI - The fate of ileorectal anastomosis in Crohn's disease. AB - An assessment has been made of 25 patients who have undergone ileorectal anastomosis for Crohn's disease. The rate of anastomotic leakage was high (32%) but was fatal in only one patient. The likelihood of leakage was not affected by a safety valve ileostomy, failure to excise all diseased bowel, or steroid therapy. The overall recurrence rate was 60 per cent. This was not affected by the age of the patient, duration of the disease, steroid therapy, or anastomotic leak but was affected adversely by the presence of concurrent small bowel disease and by residual rectal disease at the site of the anastomosis. PMID- 4326295 TI - Studies on a rhinovirus (EC11) derived from a calf. I. Isolation in calf tracheal organ cultures and characterization of the virus. PMID- 4326294 TI - Intrapulmonary lymphoid tissue of pigs exposed to aerosols of haemolytic streptococcus group L and porcine adenovirus. PMID- 4326296 TI - Studies on a rhinovirus (EC11) derived from a calf. II. Disease in calves. PMID- 4326297 TI - Saturation analysis of cyclic AMP. PMID- 4326298 TI - The effects of hypophysectomy on adrenocortical function in the duck (Anas platyrhynchos). PMID- 4326299 TI - The effect of chlorpropamide and related compounds on water transport across the toad bladder. PMID- 4326300 TI - The daily rhythm of the secretion of corticotrophin and corticosterone in rats and mice. PMID- 4326301 TI - Stimulation of the conversion of corticosterone to aldosterone by rat adrenal glomerulosa cells and tissue. PMID- 4326302 TI - Effect of sleep on memory. II. Differential effect of the first and second half of the night. PMID- 4326303 TI - Glioblastoma with extracranial metastasis through ventriculopleural shunt. Case report. PMID- 4326304 TI - Localization of acid phosphatase activity in Plasmodium berghei and P. gallinaceum: an electron microscopic observation. PMID- 4326305 TI - Penetration of Eimeria larimerensis sporozoites into cultured cells as observed with the light and electron microscopes. PMID- 4326306 TI - Recurrent inhibition from motor axon collaterals of transmission in the Ia inhibitory pathway to motoneurones. AB - 1. The effects of impulses in recurrent motor axon collaterals on reflex transmission from different types of primary afferents to motoneurones were investigated in the cat by conditioning of PSPs evoked in motoneurones.2. IPSPs evoked by volleys in large muscle spindle (Ia) afferents were effectively decreased when preceded by an antidromic stimulation of ventral roots. Some IPSPs from group II muscle afferents and low threshold cutaneous afferents were also slightly depressed, while other PSPs were unaffected.3. The depression of the IPSPs could be evoked by antidromic volleys, which produced neither conductance changes in the motoneurones nor depolarization of Ia afferent terminals.4. The effect on the Ia IPSPs is most likely due to post-synaptic inhibition of the Ia inhibitory interneurones, evoked through alpha-motor axon collaterals and Renshaw cells. The depression of some IPSPs from flexor reflex afferents is explained by a convergence of excitatory effects from these afferents on the Ia inhibitory interneurones.5. The results indicate a selective recurrent control from motor axon collaterals of the interneurones in the reciprocal Ia inhibitory pathway to motoneurones. PMID- 4326307 TI - Activation of transmitter release by strontium and calcium ions at the neuromuscular junction. AB - 1. The interaction between Ca and Sr ions on quantal transmitter release at the frog neuromuscular junction was studied, using conventional electrophysiological techniques.2. While Ca ions always activate transmitter release, the activating action of Sr ions depends on the Ca ion concentration in the medium; at low [Ca], strontium ions enhance the release, but at higher [Ca] they inhibit it. It is postulated that there is a [Ca] at which Sr ions do not affect transmitter liberation.3. When Sr activates release, its effect and the effect of Ca add in a more than linear fashion.4. Magnesium ions inhibit the release induced by Sr.5. The results can be explained by assuming that Ca and Sr act on the same site, at some stage of the process of quantal transmitter release. The affinity of both ions towards the sites is approximately the same, but the effectiveness of Sr is much smaller. PMID- 4326308 TI - The effect of tetanus toxin in the goldfish. AB - 1. The effects of tetanus toxin have been investigated both on central nervous and peripheral neuromuscular systems of goldfish.2. Tetanus toxin kills goldfish when administered in minute doses. The lethal effect is temperature dependent. Unlike mammals, in which tetanus toxin produces spastic paralysis and convulsions, the tetanus-intoxicated goldfish die with an apparently flaccid paralysis.3. Inhibition and excitation were investigated on the Mauthner cells of goldfish which had been paralysed with tetanus toxin for at least 24 hr, and which were subsequently kept alive for up to 3 days by perfusing the gills with oxygenated water. In such fish, antidromically and orthodromically excited Mauthner cells were quite normal, and there was no apparent effect on either the collateral inhibition or the crossed VIIIth nerve inhibition.4. Local injection of sublethal doses of tetanus toxin into the pectoral fin muscles produced local paralysis of the fin. Nerve-muscle preparations were isolated from such goldfish; in tetanus toxin-paralysed fins, the muscle no longer responded to stimulation of its nerve. The nerve compound action potential was still present and the muscle still responded vigorously to direct electrical stimulation.5. It is concluded that the major part of the lethal action of the toxin in the fish must be ascribed to a peripheral effect, the blocking of neuromuscular transmission. The inhibitory neuronal systems acting on the Mauthner cells of the goldfish, in apparent contrast to those acting on mammalian spinal neurones, are highly insensitive to tetanus toxin. PMID- 4326309 TI - Action potentials and release of neurohypophysial hormones in vitro. AB - 1. Isolated rat neurohypophyses were studied in vitro and the hormones released on electrical stimulation of the pituitary stalk or on exposure to excess potassium were estimated by a milk-ejection assay.2. The stalk was stimulated with trains of 500 stimuli, or multiples thereof, applied at different frequencies. Below frequencies of ca. 35 c/s, hormone release was found to depend on the total number of stimuli applied as well as on the frequency of stimulation. Above ca. 35 c/s, identical numbers of stimuli were progressively less effective as the frequency of stimulation was increased, and the dependence of the hormone output on the total number of stimuli was less apparent.3. The amplitude of the compound action potential recorded from the neurohypophysis following electrical stimulation of the stalk was found to decrease as a function of the frequency of stimulation. Stimulation at 50 c/s reduced its amplitude about sevenfold within 30 sec.4. The addition of tetrodotoxin (TTX) to the incubation media abolished the compound action potential recorded from the neural lobe as well as the release of hormones evoked by electrical stimulation. Resting release, however, was unaffected by TTX.5. In TTX-treated neural lobes, excess potassium was still effective in eliciting graded secretory responses. This indicates the independence of the release process from the action potential generating mechanism and suggests that TTX-paralysed preparations represent a useful model for the study of hormone release in the absence of conducted action potentials.6. The release of hormones from the neurohypophysis and the release of neurotransmitters at chemical synapses both depend on the entry of calcium into the nerve terminals following their depolarization by invading action potentials. In both systems, experimental separation of the release mechanism can be achieved by the use of TTX. These and other parallels suggest that the release process is similar. PMID- 4326311 TI - Ultrastructure of adenoid cystic carcinoma of salivary gland origin. PMID- 4326310 TI - [An improved fluorimetric cortisol determination in serum: diagnostic significance and therapeutic conclusions in AGC insufficiency]. PMID- 4326312 TI - Are warts cell clones? PMID- 4326313 TI - Long term effect of vasopressin on the maintenance of a conditioned avoidance response in rats. PMID- 4326314 TI - Effect of adrenalectomy and cortisol on the in vivo rate of incorporation of phenylalanine-14C into rat corticotropin. PMID- 4326315 TI - [Etiology of infectious mononucleosis]. PMID- 4326316 TI - The laboratory investigation of vesicular skin rashes. PMID- 4326317 TI - [Night sleep studies and their value in dentistry: experimental electromyographic studies]. PMID- 4326318 TI - Breed differences in parturient paresis. PMID- 4326319 TI - Intestinal haemorrhage syndrome in artificially reared lambs. PMID- 4326320 TI - [Determination of plasmatic cortisol by "protein competition". Critical evaluation of the method]. PMID- 4326321 TI - Responses of mean arterial pressure to pressor agents and diuretics in renal hypertensive and salt hypertensive rats. AB - 1. The responses of the mean arterial pressure to (-)-noradrenaline, tyramine, angiotensin II-val(5)-amide, vasopressin and rat renin have been contrasted in renal hypertensive and in salt plus desoxycorticosterone hypertensive rats. The responses were measured in rats both unanaesthetized and rats anaesthetized with pentobarbitone.2. Responses of unanaesthetized, ganglion blocked renal hypertensive rats to noradrenaline, tyramine and vasopressin markedly exceeded, and to angiotensin II and renin were markedly smaller than, those of unanaesthetized ganglion blocked salt + DOC hypertensive animals. Responses to angiotensin and to renin were apparently enhanced in the latter animals.3. Hydrochlorothiazide and frusemide markedly reduced mean arterial pressure in salt + DOC hypertensive rats before and after ganglionic blockade.4. Neither diuretic caused significant reduction in the mean arterial pressures of unanaesthetized, renal hypertensive rats in the absence of ganglionic blockade: frusemide did so in anaesthetized and unanaesthetized rats after ganglionic blockade.5. Whereas the diuretics did not affect the responses of the renal hypertensive rats to pressor agents, frusemide and to a lesser extent hydrochlorothiazide tended to depress the responses to pressor agents in salt induced hypertension.6. Hydrochlorothiazide did not influence mean arterial pressure in unanaesthetized rats with neurogenic hypertension. PMID- 4326322 TI - Effect of electrical stimulation and high potassium concentrations on the effux of (14C) glycine from slices of spinal cord. AB - 1. The effects of electrical stimulation and solutions containing a high concentration of potassium on the efflux of [(14)C] glycine from slices of rat spinal cord have been studied.2. Slices of cord were incubated with [(14)C] glycine which rapidly accumulated in the tissue. The slices were then superfused in a small chamber and the radioactivity released from the tissue was measured. After superfusion for 60 min, 98% of the radioactivity remaining in the tissue was present as unchanged glycine.3. The spontaneous efflux of [(14)C] glycine consisted of an initial rapid phase followed by a much slower release of [(14)C] glycine. After superfusion for 60 min, more than 65% of the radioactivity taken up during the incubation period was retained by the tissue.4. When the slices were depolarized by electrical stimulation or by solutions containing a high concentration of potassium (40 mM), a striking increase in the efflux of [(14)C] glycine was produced. This effect was not reduced by the absence of calcium ions in the superfusion medium.5. Electrical stimulation produced similar increases in the efflux of [(3)H] GABA and [(14)C] glutamate from slices of cord but had no significant effects on the efflux of [(3)H] alanine or [(14)C] urea.6. The results are consistent with the suggestion that glycine may be an inhibitory synaptic transmitter substance in the mammalian spinal cord. PMID- 4326325 TI - [Compensation of the ovarian corpus luteum by the adrenal cortex: nidation in the pregnant castrated rat injected with ACTH and estradiol]. PMID- 4326324 TI - Modification of the vascular response to isoprenaline by cholinomimetic drugs. AB - 1. Pilocarpine and other cholinomimetic drugs convert isoprenaline to a vasoconstrictor and pressor agent.2. This effect of pilocarpine was abolished by atropine; it is thus an acetylcholine-like response. It was not dependent on the integrity of the central nervous system or the adrenal glands and was not abolished by ganglionic blockade.3. The constrictor action of isoprenaline after pilocarpine was abolished by propranolol; this action of isoprenaline is thus on the beta-adrenoceptor. Another beta-adrenoceptor stimulating agent, salbutamol, resembled isoprenaline in this situation, though papaverine and acetylcholine did not.4. The constrictor action of isoprenaline after pilocarpine was abolished by phenoxybenzamine, guanethidine and cocaine; the effect did not appear after reserpine pretreatment.5. These results suggest an action of cholinomimetic drugs at adrenergic nerve endings which permits the uptake of beta-adrenoceptor stimulating agents resulting in the release of neuronal transmitter. PMID- 4326323 TI - Pharmacological properties of centrally administered ouabain and their modification by other drugs. AB - 1. Ouabain given by intracerebroventricular injection to mice in small doses (0.1 0.4 mug) produced a dose related depression of central nervous activity, characterized by a reduction in spontaneous locomotor activity, hypothermia, catalepsy and ptosis, lowered body posture and lack of response to external stimuli. Doses above 0.4 mug were excitatory, convulsant and lethal.2. The depressant effects could be antagonized by (+)-amphetamine, desmethylimipramine, dibutyryl cyclic 3'5'-adenosine monophosphate and caffeine.3. The MAO inhibitor nialamide produced only a small antagonism of ouabain, resulting in a greater rate of recovery from the depressant effects of ouabain.4. The depressant effects were associated with a marked elevation of whole-brain dopamine levels with little change in noradrenaline or 5-hydroxytryptamine.5. The dopamine-beta hydroxylase inhibitor sodium diethyldithiocarbamate, administered by intracerebroventricular injection, produced effects qualitatively similar to those seen after ouabain.6. An interference with central transmitter function is postulated as a possible mode of action of intracerebroventricularly injected ouabain. PMID- 4326326 TI - [Effect of Janus green on interdigital morphogenetic necrosis in the chicken: histological and cytological analysis]. PMID- 4326327 TI - Effects of mammalian corticotropin and progesterone on corticoid production by chicken adrenal tissue in vitro. PMID- 4326328 TI - Effects of intrahypothalamic betamethazone implants on adrenal function in male sceloporus cyanogenys. PMID- 4326329 TI - Effect of ACTH on gonadal blood flow in the golden hamster and the rat. PMID- 4326331 TI - Structural chemistry of cholinergic neural transmission systems. I. A quantum theoretical study of the molecular electronic structure of acetylcholine. PMID- 4326330 TI - Characterization and inhibition of corneal collagenase. PMID- 4326332 TI - Cholinergic activity in rats following enriched stimulation and training: direction and duration of effects. PMID- 4326333 TI - The action of adrenocorticotrophin on the free nucleotide pool and RNA synthesis in rat adrenals and liver. PMID- 4326334 TI - Adrenal steroid secretion in the Tasmanian devil (Sarcophilus harisii) and the Eastern native cat (Dasyurus viverrinus). A comparison of adrenocortical activity of different Australian marsupials. PMID- 4326335 TI - Effect of adrenalectomy and adrenocorticotrophic hormone on sebum secretion in the rat. PMID- 4326336 TI - The secretion of immuno-reactive luteinizing hormone and follicle-stimulating hormone by the human foetal pituitary in organ culture. PMID- 4326337 TI - The localization of corticotrophic function in the pars distalis of the pituitary in the common frog, Rana temporaria. PMID- 4326338 TI - Toward better therapy for resistant rickets. PMID- 4326339 TI - A live-born infant with 69 chromosomes. PMID- 4326340 TI - [Longitudinal conduction systems serving spinal and brainstem coordination-spino bulbo-spinal reflex]. PMID- 4326341 TI - The preparation of congenic strains of Tetrahymena. PMID- 4326343 TI - [Herpes simplex infections on the genitalia]. PMID- 4326342 TI - [Interferon production in vitro by leukocytes in lupus erythematodes disseminatus]. PMID- 4326344 TI - Vestibular neuronitis. PMID- 4326345 TI - Dizziness related to hypoglycemia: the role of adrenal steroids and nutrition. PMID- 4326346 TI - Primary carcinoma of the frontal sinus. PMID- 4326347 TI - Glomus tumor (nonchromaffin-paraganglioma) of the larynx. PMID- 4326348 TI - Airway obstruction due to a large laryngeal granular cell myoblastoma. PMID- 4326349 TI - [Epidemiologic diagnostic value of negative serums and low CBR titer values in the diagnosis of influenza]. PMID- 4326350 TI - Adequate hemodialysis schedule. PMID- 4326351 TI - A human C-type virus. PMID- 4326352 TI - Effect of cyclic AMP on release of lysosomal enzymes from phagocytes. PMID- 4326353 TI - Apparent differences in transcriptional control in cells productively infected and transformed by SV40. PMID- 4326355 TI - Transformation of polyoma virus affects adhesion of fibroblasts. PMID- 4326356 TI - [Breast cancer with late recurrence. A preliminary report]. PMID- 4326354 TI - Lac DNA, RNA polymerase and cyclic AMP receptor protein, cyclic AMP, lac repressor and inducer are the essential elements for controlled lac transcription. PMID- 4326357 TI - [Role of combined viro-viral and viro-bacterial infections upon the course of some diseases in children]. PMID- 4326358 TI - [Some indications of enzymatic activity of intestines in children with acute dysentery]. PMID- 4326359 TI - [Pharmacodynamic evaluation of synthetic prolonged-action ACTH on the adrenal function of patients with hypothalamo-pituitary pathology. Comparative study of synthetic ACTH and extra-delayed-action gel]. PMID- 4326361 TI - [Contribution of electroencephalography to the diagnosis of intracraneal expansive processes]. PMID- 4326360 TI - Relation of psychologic measures of aggression and hostility to testosterone production in man. PMID- 4326362 TI - Neurologic features of lepromatous leprosy. PMID- 4326363 TI - Effect of tryptophan on polyribosomes and protein synthesis in liver. PMID- 4326364 TI - Effects of steroid conjugates on availability of pyridoxal phosphate for kynureninase and kynurenine aminotransferase activity. PMID- 4326365 TI - Hormonal alteration of efficiency of conversion of tryptophan to urinary metabolites of niacin in man. PMID- 4326367 TI - Juvenile papilloma of the larynx. PMID- 4326368 TI - Chronic localized nonprogressive vaccinia during infectious hepatitis. PMID- 4326366 TI - Congenital ring constrictions and intrauterine amputations. PMID- 4326369 TI - Recent advances in radiation therapy. PMID- 4326370 TI - A study of the postoperative course after hepatic lobectomy. PMID- 4326371 TI - Norepinephrine in a glomus jugulare tumor. Histochemical demonstration. PMID- 4326372 TI - Antigens of nasopharyngeal carcinoma. PMID- 4326373 TI - An experimental examination of the scrapie agent in cell membrane mixtures. II. The association of scrapie activity with membrane fractions. PMID- 4326374 TI - Prevention of catheter-induced post-prostatectomy infection. Effects of systemic cephaloridine and local irrigation with neomycin-polymyxin through closed drainage catheter system. PMID- 4326375 TI - [Cancer of the breast. 1. Developmental pathology (etiology and morphogenesis)]. PMID- 4326376 TI - Etiologic correlations between idiopathic polyneuritis and multiple sclerosis: therapeutic implications. PMID- 4326377 TI - Current methods of therapy in multiple sclerosis. PMID- 4326378 TI - [Cytochrome oxidase activity in glial tissue cultured in vitro]. PMID- 4326379 TI - [Experimental studies on circulatory insufficiency in the brain]. PMID- 4326380 TI - Severe preeclampsia, disseminated intravascular coagulopathy and hydatidiform mole complicating a 20-week pregnancy with a fetus. PMID- 4326381 TI - [Influence of sialoadenectomy and cyanide on the stress loop]. PMID- 4326382 TI - Insulin and growth hormone regulation in organic hyperinsulinism. PMID- 4326383 TI - [Intrauterine infection caused by influenza, Coxsackie and adenoviruses]. PMID- 4326384 TI - [Permeability of the rat placenta in relation to ristomycin]. PMID- 4326385 TI - Serratia marcescens as a postoperative pathogen. PMID- 4326386 TI - [Glyco-active adrenocortical function in the elderly. Dynamic tests using metopirone, dexamethasone and bacterial pyrogen]. PMID- 4326387 TI - [A case of Cushing's disease treated by aminoglutethimide]. PMID- 4326388 TI - [Seminoma (dysgerminoma) of the ovary with symptoms of virilization]. PMID- 4326389 TI - Erythrokeratodermia variabilis. An enzyme histochemical and ultrastructural study. PMID- 4326390 TI - Interferon in mouse brain. PMID- 4326391 TI - Subcortical commissural interactions between the thalamic trigeminal relay nuclei. PMID- 4326392 TI - Statistical analysis of single neuron spontaneous discharge, in the cat visual cortex. PMID- 4326393 TI - [Effects of histamine on neuromuscular transmission in the frog]. PMID- 4326394 TI - [Spontaneous maturation of viruses in cells transformed by polyoma virus. (Immunofluorescence studies)]. PMID- 4326395 TI - [Antigenic composition of the hamster cells transformed by polyoma virus]. PMID- 4326396 TI - Studies on phosphoproteins from fish eggs. II. Enzymatic dephosphorylation of herring egg phosphoprotein by phosphatase preparations from citrus fruit. PMID- 4326397 TI - Factors regulating thymidine kinase in regenerating liver. PMID- 4326398 TI - Specificity of anti-poly G-poly C antibodies. PMID- 4326399 TI - Role of macrophages and antibody in resistance of mice against yellow fever virus. PMID- 4326400 TI - Lysophosphatidylethanolamine and 2-desoxylysophosphatidylethanolamine derivatives. 1. Potential renin inhibitors. PMID- 4326401 TI - Antiviral agents. 1. Benzothiazole and benzoxazole analogs of 2-(alpha hydroxybenzyl)benzimidazole. PMID- 4326402 TI - Replicative structures of poliovirus RNA in vivo. PMID- 4326403 TI - Properties of the product synthesized by vesicular stomatitis virus particles. PMID- 4326404 TI - A study of rapid hydrogen exchange in nucleic acids. PMID- 4326405 TI - Herpesvirus antibody and carcinoma in situ of the cervix. PMID- 4326406 TI - Tumors potentiating catecholamine-induced hypertension. PMID- 4326407 TI - Reinforcement by Na+ of centrally mediated hypertensive response to angiotensin II. PMID- 4326409 TI - [Hypoparathyroidism]. PMID- 4326408 TI - [Ulcerative colitis]. PMID- 4326410 TI - [Cushing's syndrome]. PMID- 4326411 TI - [Pharyngo-conjunctival fever]. PMID- 4326412 TI - [Prostatic cancer]. PMID- 4326414 TI - [Myasthenia gravis]. PMID- 4326413 TI - [Hemophilia]. PMID- 4326415 TI - [SMON(subacute-myelo-optico-neuropathy)]. PMID- 4326416 TI - [Devic's disease]. PMID- 4326417 TI - [Effect of increasing doses of carbon tetrachloride on rat microsomal enzymes with and without phenobarbital pretreatment]. PMID- 4326418 TI - [Renin substrate reaction and renin release by the isolated rabbit kidney]. PMID- 4326419 TI - [Conversion of angiotensin I in the rat peripheral circulation]. PMID- 4326420 TI - [Effects of D-lysergic acid diethylamide (LSD-25) and 2-bromo-D-lysergic acid diethylamide (BOL-148) on sleeping behavior in rats]. PMID- 4326421 TI - [Selective inhibition of DNA synthesis and tumorigenesis by 7,12 dimethylbenz(a)anthracene in regenerating rat liver]. PMID- 4326422 TI - [Insulin secretion and NADH-fluorescence of isolated pancreatic islets]. PMID- 4326423 TI - [Blood pressure effects of noradrenaline and angiotensin in hypertensive and normotensive rats]. PMID- 4326424 TI - [Estimation of the speed of action and detoxication capacity of cyanide antidotes on the basis of hydrocyanic acid exhalation]. PMID- 4326425 TI - [Subcellular distribution of gastrin in the rabbit antral mucosa]. PMID- 4326426 TI - [Activity of the renin-angiotensin system in entotoxin shock and during orthostatic loading of rabbits under corticosteroid therapy]. PMID- 4326427 TI - [Influence of metyrapone on redox state and oxygen consumption of isolated perfused rat livers]. PMID- 4326428 TI - [Mechanism of action of angiotensin on postganglionic sympathetic nerves]. PMID- 4326429 TI - [Changes in some oxidizing enzymes in blood serum and leukocytes in chronic pneumonia in children]. PMID- 4326430 TI - [Clinical manifestations and therapy of respiratory diseases of adenoviral etiology in nurseries]. PMID- 4326431 TI - Reduction of platelet serotonin and the response to pulmonary emboli. PMID- 4326432 TI - [Drug-induced polyneuropathy]. PMID- 4326433 TI - The effect of unilateral medial forebrain bundle lesion on 5-hydroxytryptamine in the pigeon brain. PMID- 4326434 TI - The effects of an inhibitor of Na plus -K plus -active transport on the secretory activity of rat submaxillary gland cell cultures. PMID- 4326435 TI - [The pineal complex of the ammocoete (Lampetra planeri). Connections of the pineal and parapineal organs with the epithalamic roof]. PMID- 4326436 TI - Fine structural and enzymehistochemical observations on the notochord of Ichthyophis glutinosus and Ichthyophis kohtaoensis (Gymnophiona, Amphibia). PMID- 4326437 TI - [The treatment of the colic states of amoebian nature and origin]. PMID- 4326438 TI - In vitro activity of gentamicin, alone and in combination with other antibiotics. PMID- 4326440 TI - Evaluation of cross reactions within the enterovirus group using neutralization tests. PMID- 4326439 TI - Antibody-combining oligosaccharides from a chick allantoic glycopeptide sulphate associated with influenza virus haemagglutinin. PMID- 4326441 TI - Japanese B encephalitis in Vietnam. PMID- 4326442 TI - Phosphatases: applications of new methods for their separation. PMID- 4326443 TI - A useful spectrophotometric rate assay for pepsin. PMID- 4326444 TI - Separation of cyclic 3',5'-nucleoside monophosphates from other nucleotides on aluminum oxide columns. Application to the assay of adenyl cyclase and guanyl cyclase. PMID- 4326445 TI - Group separation of delta4-3-oxosteroids and delta5-3beta-hydroxysteroids by chromatography on digitonin-silica thin layers. PMID- 4326446 TI - Use of cetyl trimethylammonium bromide for estimation of the in vivo incorporation of radioactive precursors into RNA. PMID- 4326447 TI - Characterization of collagen peptides by sodium dodecylsulfate-polyacrylamide electrophoresis. PMID- 4326448 TI - [2 Syrian hamster cell lines transformed by SV40 and non-inducible viruses]. PMID- 4326449 TI - [Role of bacteria in the digestive tube of insects, vectors of plasmodidae and trypanosomidae]. PMID- 4326450 TI - [Surgical anatomy, kinesiology and propedeutics of the hand]. PMID- 4326451 TI - [Treatment of hypersensitivity to sun rays by ACTH]. PMID- 4326452 TI - [Serum titers of immunoglobulin A. M. G. in Ivory Coast adults]. PMID- 4326453 TI - Temporal genetic mapping of the blue-green alga, Anacystis nidulans. PMID- 4326454 TI - [Influence of the nominal freezing rate on histological changes and on acid phosphatases, ribonucleases and peptidases of bovine muscle]. PMID- 4326455 TI - Correlation between pinocytosis and hydroosmosis induced by neurohypophyseal hormones and mediated by adenosine 3',5'-cyclic monophosphate. AB - The isolated urinary bladder of the toad responds to neurohypophyseal hormone with a net increase of water transport from the mucosal to the serosal solution in the presence of an osmotic gradient. This response is mediated intracellularly by cyclic 3',5'-adenosine monophosphate (AMP). The present study demonstrates that hydroosmotically active substances such as oxytocin, dibutyryl cyclic 3',5' AMP, and theophylline, but not hydroosmotically inactive substances, induce the uptake of horseradish peroxidase from the mucosal solution. Peroxidase taken up by the mucosal cells is demonstrable in small tubules and vesicles, and eventually accumulates in lysosomes. The uptake of peroxidase from the serosal solution into similar bodies in the mucosal cells is not hormone-dependent. It is also shown that peroxidase does not penetrate the tight junction from either the mucosal or serosal solution. These results extend previous findings which implicated the apical membrane of the mucosal epithelium as the site affected by neurohypophyseal hormones. A mechanism based on secretory phenomena is proposed as a framework for future investigations of apical membrane permeability changes and pinocytosis. PMID- 4326457 TI - Thick filaments in vascular smooth muscle. AB - Two sets of myofilaments were demonstrated after incubation of strips of rabbit portal-anterior mesenteric vein under moderate stretch in a physiological salt solution. Thick filaments had a mean diameter of 18 nm and reached a maximum length of 1.4 microm with a mean length of 0.61 microm. In transverse sections, 2.5-5 nm particles were resolved as subunits of the thick filaments. Thin filaments had an average diameter of 8.4 nm and generally conformed to the structure believed to represent actin filaments in smooth and striated muscles. In the areas of maximum concentration there were 160-328 thick filaments/microm(2) and the lowest ratio of thin to thick filaments was 12:1. Thick filaments were present in approximately equal numbers in vascular smooth muscle relaxed by theophylline, in Ca(++)-free solution, or contracted by norepinephrine. The same preparatory procedures used with vascular smooth muscle also enabled us to visualize thick filaments in guinea pig and rabbit taenia coli and vas deferens. PMID- 4326456 TI - Ultrastructure and function of growth cones and axons of cultured nerve cells. AB - Dorsal root ganglion nerve cells undergoing axon elongation in vitro have been analyzed ultrastructurally. The growth cone at the axonal tip contains smooth endoplasmic reticulum, vesicles, neurofilaments, occasional microtubules, and a network of 50-A in diameter microfilaments. The filamentous network fills the periphery of the growth cone and is the only structure found in microspikes. Elements of the network are oriented parallel to the axis of microspikes, but exhibit little orientation in the growth cone. Cytochalasin B causes rounding up of growth cones, retraction of microspikes, and cessation of axon elongation. The latter biological effect correlates with an ultrastructural alteration in the filamentous network of growth cones and microspikes. No other organelle appears to be affected by the drug. Removal of cytochalasin allows reinitiation of growth cone-microspike activity, and elongation begins anew. Such recovery will occur in the presence of the protein synthesis inhibitor cycloheximide, and in the absence of exogenous nerve growth factor. The neurofilaments and microtubules of axons are regularly spaced. Fine filaments indistinguishable from those in the growth cone interconnect neurofilaments, vesicles, microtubules, and plasma membrane. This filamentous network could provide the structural basis for the initiation of lateral microspikes and perhaps of collateral axons, besides playing a role in axonal transport. PMID- 4326458 TI - Sites of cytoplasmic ribonucleoprotein-filament assembly in relation to helical body formation in axenic trophozoites of Entamoeba histolytica. AB - Axenic trophozoites of Entamoeba histolytica showed increased logarithmic growth but absence of "chromatoid" material (stacked helical arrays of ribonucleoprotein [RNP]) when grown in an all-liquid monophasic culture. Organisms grown in a liquid overlay on a semisolid slant (biphasic medium) showed slow logarithmic growth and the presence of chromatoid material. Chromatoid material accumulated in the rapidly growing trophozoites from monophasic culture during treatment with the Vinca alkaloid, vinblastine. Many of the glycogen-free regions of vinblastine treated trophozoites as well as, to a lesser degree, of normal cells grown in monophasic and biphasic cultures, contained free ribosomes and randomly oriented 60 A filaments. As ribonucleoprotein assumed the packed helical configuration, areas consisting of parallel, packed filaments could be detected adjacent to and continuous with the ordered RNP arrays. This arrangement could be visualized most frequently in vinblastine-treated trophozoites grown in monophasic cultures. Depending on the tilt of the section with respect to the longitudinal axis of individual helices, 60 A filamentous material could be demonstrated associated with the RNP helices. Localization of ribonucleoprotein precursors was followed by means of high resolution radioautography with uridine-(3)H and cytidine-(3)H. With a short (30-min) pulse, label could be visualized only over the glycogen free areas containing free ribosomes and filaments. With 60-min pulses, label could also be seen over the packed helical arrays. With 30-min pulses followed by a 60-min cold chase, label was seen chiefly over RNP helices. It is postulated that the areas containing ribosomes and filaments represent sites of assembly of the RNP helices possibly on a filament protein column. The possibility that the final helical configuration may be due to a property of this protein is suggested. PMID- 4326460 TI - A comparative study of sebaceous gland ultrastructure in subhuman primates. II. Macaques: crystalline inclusions in the sebaceous cells of Macaca mulatta, M. nemestrina, M. speciosa, M. fascicularsis. PMID- 4326459 TI - Radioautographic study of in vivo and in vitro incorporation of fucose-3H into thyroglobulin by rat thyroid follicular cells. AB - The incorporation of fucose-(3)H in rat thyroid follicles was studied by radioautography in the light and electron microscopes to determine the site of fucose incorporation into the carbohydrate side chains of thyroglobulin, and to follow the migration of thyroglobulin once it had been labeled with fucose-(3)H. Radioautographs were examined quantitatively in vivo at several times after injection of fucose-(3)H into rats, and in vitro following pulse-labeling of thyroid lobes in medium containing fucose-(3)H. At 3-5 min following fucose-(3)H administration in vivo, 85% of the silver grains were localized over the Golgi apparatus of thyroid follicular cells. By 20 min, silver grains appeared over apical vesicles, and by 1 hr over the colloid. At 4 hr, nearly all of the silver grains had migrated out of the cells into the colloid. Analysis of the changes in concentration of label with time showed that radioactivity over the Golgi apparatus increased for about 20 min and then decreased, while that over apical vesicles increased to reach a maximum at 35 min. Later, the concentration of label over the apical vesicles decreased, while that over the colloid increased. Similar results were obtained in vitro. It is concluded that fucose, which is located at the end of some of the carbohydrate side chains, is incorporated into thyroglobulin within the Golgi apparatus of thyroid follicular cells, thereby indicating that some of these side chains are completed there. Furthermore, the kinetic analysis demonstrates that apical vesicles are the secretion granules which transport thyroglobulin from the Golgi apparatus to the apex of the cell and release it into the colloid. PMID- 4326461 TI - [Problems in nasopharyngeal carcinoma--question of the virus as the etiological agent. Research overview]. PMID- 4326463 TI - [Virologic examination in nasopharyngeal carcinoma]. PMID- 4326462 TI - [Epidemiology of nasopharyngeal cancer--from the standpoint of natural history of herpes type virus infection]. PMID- 4326464 TI - [Cytogenesis of so-called "lymphoblastoid cell line" possessing EB virus]. PMID- 4326465 TI - [Cell membrane receptor of cultured cells derived from nasopharyngeal carcinoma, Burkitt's lymphoma and infectious mononucleosis]. PMID- 4326466 TI - [Changes in cell membrane infected with herpes simplex virus]. PMID- 4326467 TI - [Antinuclear antibody]. PMID- 4326468 TI - [Natural history of EB virus in man--studies on Izumi fever as an EB virus infection]. PMID- 4326469 TI - [Etiology of Izumi fever]. PMID- 4326470 TI - [Biology of EB virus with special reference to a new antigen]. PMID- 4326471 TI - [Discussion on problems of nasopharyngeal carcinoma]. PMID- 4326472 TI - Interaction of dietary fat and thyroid function with hepatic and renal gluconeogenesis of rats. PMID- 4326473 TI - [Histological aspects of the juxtaglomerular apparatus in experimental saturnism]. PMID- 4326474 TI - [Criteria for the determination of maximum tolerable concentration of silica and asbestos in the air]. PMID- 4326476 TI - [Influence of exogenous stress on the 11-hydroxycorticosteroid plasma concentration and the behavior of eosinophilic granulocytes in cattle]. PMID- 4326475 TI - [Toxins and anatoxins of Clostridium perfringens]. PMID- 4326477 TI - [Use of the cofal test. 1. Production of antiserums and demonstration of gs antigens in organ tissue]. PMID- 4326478 TI - Chromosome aberrations induced by x-ray therapy and myxovirus infection in human peripheral leukocytes. PMID- 4326479 TI - [Diagnosis and treatment of the Guillain-Barre syndrome (polyradiculitis subacuta curabilis) in children]. PMID- 4326480 TI - [Peripheral origins of brachialgia]. PMID- 4326481 TI - [Neuritic pains in shoulder and arm]. PMID- 4326482 TI - [Eye motility disorders in lesions of the central nervous system]. PMID- 4326483 TI - [Study of herpes simplex virus replication in gamma-irradiated cultures of human cells]. PMID- 4326484 TI - [The muscle in rheumatoid polyarthritis. Biochemical and electromyographic study]. PMID- 4326485 TI - [Immunoelectron microscopic studies on mouse mammary tumor virus and leukemia virus]. PMID- 4326486 TI - [Autopsy case of orbital aspergillosis with manifestations of orbital apex syndrome]. PMID- 4326487 TI - [Thoughts on pulmonary tuberculosis in the aged]. PMID- 4326489 TI - [Disorders of cardiac rhythm in the aged]. PMID- 4326488 TI - [Sedimentation rate and electrophoresis in the aged]. PMID- 4326490 TI - [Delay in hospitalization of recent infarcts]. PMID- 4326491 TI - [Medicine and legal responsibility]. PMID- 4326492 TI - [On a case of hepatic tuberculosis treated with rifampicine]. PMID- 4326493 TI - Electron microscopy of an axenic strain (Laredo) of Entamoeba hisolytica. PMID- 4326494 TI - A poxvirus infection of gerbils in Uganda. PMID- 4326495 TI - [Orientational animal experiments on the toxicity, resorption and effect of a mixture of proteolytic enzymes]. PMID- 4326496 TI - Techniques for the isolation of cells of the adrenal cortex, the anterior pituitary and the corpus luteum: morphological and functional evaluation of the isolated cells. PMID- 4326497 TI - Skeletal and tooth development. A methodologic investigation. PMID- 4326498 TI - [Tuberculosis of the genitalia and tumors of the female sex organs]. PMID- 4326499 TI - Diagnosis and acute management of patients with advanced clostridial sepsis complicating abortion. PMID- 4326500 TI - Effects of exercise on cardiac weight and mitochondria in male and female rats. PMID- 4326501 TI - Urachal abnormalities in the adult. PMID- 4326502 TI - A temperature marker test for the differentiation of strains of Herpesvirus hominis. PMID- 4326503 TI - [Research on the toxicity of polyphenyls. I. Preliminary histopathological and enzymological studies]. PMID- 4326504 TI - [Effect of preventive administration of reserpine on proteinuria induced with angiotensin in rats]. PMID- 4326505 TI - [Effect of nephrectomy on serum protein changes induced with angiotensin in the rat]. PMID- 4326506 TI - [Stimulation in vitro by the 2 hypophyseal gonadotropic hormones (LH and FSH) of the adenylcyclasic activity of the ovary in the prepuberal female rat]. PMID- 4326507 TI - [Biochemical study of depletion by collagenase and of restoration of chick embryo vertebral cartilage in culture in vitro]. PMID- 4326508 TI - [Influence of an isolation stress on the development of transplanted ascites tumors in mice. Role of the adrenals]. PMID- 4326509 TI - [Change in sodium conductance of the nodal membrane as a function of Na+ ion concentration]. PMID- 4326510 TI - [Some enzymes and isoenzymes in mammalian cells infected with Teschen disease virus and pseudorabies virus]. PMID- 4326511 TI - [Diagnostic and therapeutic problems of petit mal. Considerations of a longitudinal study]. PMID- 4326512 TI - The Lesch-Nyhan syndrome. PMID- 4326514 TI - Reflex responses in the sympathetic and vagal nerve evoked by reticular stimulation during sleep and wakefulness. PMID- 4326513 TI - Behaviour of some enzymes and isoenzymes in plasma liver and bile of rats treated with carbon tetrachloride. PMID- 4326515 TI - A clinical study of partial liver irradiation. PMID- 4326516 TI - Gangrene of the entire large intestine in the seventh month of pregnancy without occlusion of the intestinal vessels. PMID- 4326517 TI - [Mechanism of photochemical synthesis of amino acids during the action of UV-rays on a solution of formaldehyde and ammonium salts]. PMID- 4326518 TI - The concentrations of adrenocorticotrophin, vasopressin and oxytocin in the foetal and maternal plasma of the sheep in the latter half of gestation. PMID- 4326519 TI - [Postsynaptic responses of thalamic neurons evoked by low frequency stimulation of the caudate nucleus]. PMID- 4326520 TI - Structural change of pterinosome (pteridine pigment granule) during the Xanthophore differentiation of Oryzias fish. PMID- 4326521 TI - [Gas chromatographic estimation of urinary delta5 pregnenetriol and pregnanetriol in adrenocortical disease and male hypogonadism]. PMID- 4326522 TI - The influence of postnecrotic cirrhosis on aflatoxin carcinogenesis in rats. PMID- 4326524 TI - Small intestinal absorption of horseradish peroxidase. A cytochemical study. PMID- 4326523 TI - Pathologic lysosomes and increased urinary glycosylceramide excretion in Fabry's disease. Studies on a family with evidence of linkage with the sex-linked blood group Xg. PMID- 4326525 TI - An ultrastructural study of Tyzzer's disease in the Mongolian gerbil (Meriones unguiculatus). PMID- 4326526 TI - [Toxic infections of Clostridium perfringens type A in birds of prey]. PMID- 4326527 TI - Inapproprioception: a possible sensory basis for athetoid movements. PMID- 4326528 TI - [Renovascular arterial hypertension. II. Comparison of different studies allowing one to foresee the effect of surgery on the hypertension. I]. PMID- 4326529 TI - [Stimulation of growth hormones in children with ACTH]. PMID- 4326530 TI - [Problems posed by the treatment of neurologic and neuropsychic manifestations of systemic lupus erythematosus]. PMID- 4326531 TI - [Summary of a systematic search for alpha-1-feto-protein in 224 hepatic diseases]. PMID- 4326532 TI - [Jaundice and rifampicin]. PMID- 4326534 TI - [Costs of medical analyses in Social Security expenditures (report of the Audit Office)]. PMID- 4326533 TI - [Iron metabolism]. PMID- 4326535 TI - Cytomegalovirus-induced postperfusion syndrome. PMID- 4326536 TI - [Direct radiographic examination of the pancreas]. PMID- 4326537 TI - Presence and inactivation of foot-and-mouth disease virus in animal faeces. PMID- 4326538 TI - Antigens of Herpes simplex virus type 1 and 2-immunodiffusion and inhibition passive hemagglutination studies. PMID- 4326539 TI - [Induction of neurogenic malignancies by one single dose of ethyl-nitrosourea (ENU) given to newborn and juvenile BD IX-strain rats]. PMID- 4326541 TI - The influence of the nigro-neostriatal dopamine pathway on spinal motoneuron activity. PMID- 4326540 TI - Dopa-decarboxylase in autonomic and sensory ganglia of the cat. PMID- 4326542 TI - The effect of protriptyline on uptake and retention of dl-3H-noradrenaline in different tissues of the rat. PMID- 4326543 TI - Transmission in superior cervical ganglion of the dog after cholinergic suppression. PMID- 4326544 TI - Gastric motility inhibition and excitation elicited by vagal stimulation. PMID- 4326545 TI - Vascular responses to prostaglandin E1 in gracilis muscle and hindpaw of the dog. PMID- 4326546 TI - Prolonged water diuresis affecting solutes and interstitial cells of renal papilla. PMID- 4326547 TI - Relationship of chemically initiated enzyme secretion to metabolism in rat parotid in vitro. PMID- 4326549 TI - [Experiments on the cultivation of hoof-and-mouth disease virus type A5 in shaker flask suspension cultures and in combination with monolayer cultures in Roux flasks]. PMID- 4326548 TI - Familial progressive hyperpigmentation. PMID- 4326550 TI - [Pathomorphologic findings in the rat pancreas resulting from a protein-deficient diet]. PMID- 4326552 TI - Stimulation of central cardiovascular centers in hypertension. PMID- 4326551 TI - The effect of dopamine and other catecholamines on neuromuscular transmission. PMID- 4326553 TI - Synovial sarcoma of the tongue. PMID- 4326554 TI - Ossifying fibroma of the middle ear. Report of a case. PMID- 4326555 TI - A demonstration of corticotropic activity and its distribution in the pars distalis of the reptile. PMID- 4326556 TI - In vitro corticosteroidogenesis in primates: a comparative study. PMID- 4326557 TI - In vitro studies of the calculus-inhibiting properties of tooth surface polishing agents and chelating agents. PMID- 4326558 TI - [Tabetic Parinaud's syndrome]. PMID- 4326559 TI - [Vertical transmission of leukemia virus--sarcoma virus and brain tumor induced by the virus]. PMID- 4326560 TI - [Action of a metronidazole-spiramycin association on anaerobic bacteria]. PMID- 4326561 TI - [Metabolic regulation in aerobic cell suspensions of Saccharomyces carlsbergensis after glucose addition. I. Shift from respiration to aerobic fermentation]. PMID- 4326563 TI - BHK cells doubly transformed by Rous virus and polyoma virus: karyological study. PMID- 4326564 TI - [Dependence of Ca2+ transport in different tissue preparations on addition of inorganic phosphate]. PMID- 4326565 TI - [Management and practical aspects of angiologic dispensary care]. PMID- 4326562 TI - A comparison of the fine structure and nucleic acid biochemistry of chloroplasts and blue-green algae. PMID- 4326566 TI - [Effect of conditions on the reaction of yeast inorganic pyrophosphatase with the substrate]. PMID- 4326567 TI - [Structural analysis of tumor tissue lecithins]. PMID- 4326568 TI - [Varying metabolic stability of messenger RNA of mitochondria from normal and regenerating liver and transplantable hepatoma]. PMID- 4326569 TI - [Cerebral isotope seriography]. PMID- 4326570 TI - [Nature of Purkinje afterimages]. PMID- 4326571 TI - Giant parotid tumors. PMID- 4326572 TI - Management of esophageal problems in patients with collagen vascular disease. PMID- 4326573 TI - Clinical neuromuscular pharmacology of pancuronium. PMID- 4326574 TI - [Ochronosis: anatomoclinical and ultrastructural aspects]. PMID- 4326575 TI - [Occurrence of Clostridium perfringens and its toxins in the intestinal tract of swine and its significance as an etiologic agent]. PMID- 4326576 TI - Etiologic study of nasopharyngeal cancer. PMID- 4326577 TI - Bilateral benign mixed tumor of the deep lobe of the parotid gland. PMID- 4326578 TI - The metabolism of laryngeal muscles. Its influence on the physiology and pathology of the glottis. PMID- 4326579 TI - A spin label study of the recombined lipid and apoprotein of human erythrocyte membranes. PMID- 4326580 TI - Binding of transfer factor II to ribosomal RNA and inhibition of the binding by guanosine nucleotides. PMID- 4326581 TI - Oxidation state dependent circular dichroic behavior of cytochrome oxidase in the 600 nm region. PMID- 4326582 TI - A carboxylic acid intermediate of lanostenol demethylation. PMID- 4326583 TI - N6-(Delta 2-isopentenyl)adenosine: biosynthesis in vitro in transfer RNA by an enzyme purified from Escherichia coli. PMID- 4326584 TI - The incorporation of 14C-amino acids into the contractile protein of intact mitochondria: a correction. PMID- 4326585 TI - [Estradiol, cyclic AMP and nucleolar RNA polymerase in the heifer uterus]. PMID- 4326586 TI - [Effects of cyclic 3'5' AMP on the development of pancreatic islands of Langerhans]. PMID- 4326587 TI - [Virus production in the fibroblasts of chickens treated with deoxyribonucleic acid of rat XC cells transformed by Rous virus]. PMID- 4326589 TI - Arylsulfatase activity in Gorgoderina attenuata and Haematoloechus medioplexus: cytochemical and biochemical observations on the digestive tracts of digenetic trematodes. PMID- 4326588 TI - Fasciola hepatica: cytochrome c oxidoreductases and effects of oxygen tension and inhibitors. PMID- 4326590 TI - Megalodiscus temperatus: comparative radioautography of glucose-3H and galactose 3H incorporation. PMID- 4326591 TI - Cytochemical and biochemical observations on the digestive tracts of digenetic trematodes. 8. Acid phosphatase activity in Schistosoma mansoni and Schistosomatium douthitti. PMID- 4326592 TI - Radiologic seminar CIX. Synovial sarcoma in the lower extremity. PMID- 4326593 TI - [Petrous bone destruction by angioma-like process]. PMID- 4326594 TI - Cytomegalovirus infection in patients receiving long-term hemodialysis. PMID- 4326595 TI - [Common cold]. PMID- 4326596 TI - The composition of beef heart cardiolipins isolated by solvent and chromatographic fractionation. PMID- 4326597 TI - Inhibition of fat cell lipolysis by low FFA to albumin ratios. PMID- 4326599 TI - [Mass food poisoning by custard contaminated with Clostridium perfringens type A]. PMID- 4326598 TI - [Preservation of pig liver by hypothermia, perfusion, hyperbaric oxygen. II. Histoenzymologic study]. PMID- 4326600 TI - [Biochemical studies of the action of immunosuppressive substances]. PMID- 4326601 TI - An infrared thermography study on the duration of intercostal nerve blocks using bupivacaine with and without adrenaline. PMID- 4326603 TI - Epidemiology of the common cold in military recruits with emphasis on infections by rhinovirus types 1A, 2, and two unclassified rhinoviruses. PMID- 4326602 TI - Influence of some vaso-active substances on regional blood flow in the dog kidney. A study on normovolaemic and hypovolaemic dogs. PMID- 4326604 TI - Endemic smallpox in rural East Pakistan. II. Intervillage transmission and infectiousness. PMID- 4326605 TI - Reovirus antibody in primates. PMID- 4326606 TI - Fluorometric measurement of glutamine and asparagine using enzymic methods. PMID- 4326607 TI - Extraction and recovery of angiotensin II from plasma. PMID- 4326608 TI - A semiautomated method for determination of NADH-methemoglobin reductase activity. PMID- 4326609 TI - A simple method for the separation of inosinic acid from a mixture of ribonucleotides. PMID- 4326610 TI - [Focal dermal hypoplasia. Apropos of 2 cases]. PMID- 4326611 TI - [Multiple histiocytofibroma of the fingers]. PMID- 4326613 TI - Correlation in ultrastructural cryoinjury of mitochondria with aspects of their respiratory function. PMID- 4326612 TI - Incorporation of amino acids into proteins catalyzed by prostate nuclei. PMID- 4326614 TI - Structure of HeLa cells after treatment with glycerol as revealed by freeze etching and electron microscopic methods. PMID- 4326615 TI - Uropod formation in phytohaemagglutinin (PHA) stimulated lymphocytes. PMID- 4326616 TI - Lecithin-chloroform interaction as a model for the action of general anesthetics. PMID- 4326618 TI - Inhibition of Novikoff ascites cell transplantation by a polysaccharide component in bull seminal plasma. PMID- 4326617 TI - Influence of dihydroergotamine on the lipolytic system of isolated dog fat cells. PMID- 4326621 TI - Demonstration of glucose 6-phosphatase activity in hepatocytes following transparenchymal perfusion fixation with glutaraldehyde. PMID- 4326620 TI - SV 40 virus transformed prostatic carcinoma in the hamster. II. Comparisons of lactate dehydrogenase isoenzymes with human prostatic cancer. PMID- 4326622 TI - Experimental zoster-like herpes simplex in hairless mice. PMID- 4326624 TI - Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 32-1971. PMID- 4326623 TI - Left ventricular function in chronic obstructive lung disease. PMID- 4326625 TI - Abortions and unrecognized trophoblastic disease. PMID- 4326626 TI - Treatment of murine leukaemia with heterologous antiserum or cyclophosphamide. PMID- 4326627 TI - The effect of temperature on the hemagglutinin activity of the canine adenovirus (infectious canine hepatitis virus). PMID- 4326628 TI - [Structure, multiplication and oncogenic effect of chicken leukosis-sarcomatosis viruses]. PMID- 4326629 TI - Effects of fixation on vasopressin-induced formation of intercellular spaces in the toad urinary bladder. PMID- 4326630 TI - Effects of dietary copper loading on livers of rats. I. Changes in subcellular acid phosphatases and detection of an additional acid p-nitrophenylphosphatase in the cellular supernatant during copper loading. AB - Significant changes occurred in lysosomal structure and function as copper was metabolized by rat livers. Hepatic total acid p-nitrophenylphosphatase (pNphiPase) activity was markedly increased in copper-loaded rats, and this increase was almost completely accounted for by heat- and formalin-stable (HFS) acid pNphiPase. Heat- and formalin-labile acid pNphiPase was essentially unchanged. On a subcellular level, the microsomal and supernatant fractions reflected the greatest relative increase in HFS acid pNphiPase. Increases in lysosomal, HFS acid pNphiPase in the large-granule fractions correlated with increase in solubilized large-granule enzymes, LG I, with mol wt > 200,000. LG II, representng solubilized large-granule enzymes with mol wt < 200,000, remained unchanged. Marked increases in supernatant acid pNphiPase were principally accounted for by a sevenfold increase in a supernatant lysosomal-like enzyme, DEAE Pk 1, separated by DEAE cellulose chromatography. An additional enzyme, DEAE Pk 2A', that was hardly or not detectable in normal rats, was consistently demonstrated and increased in copper-loaded rats. Serum HFS acid pNphiPase increased in copper-loaded rats, suggesting that the increased hepatic supernatant acid pNphiPase in part escaped into the circulating fluid. Copper was principally associated with cytoplasmic organelles and was highest in mitochondrial and lysosomal fractions. PMID- 4326631 TI - Localized skin changes induced by depot injections of vitamin A in the rat. AB - Consistent local dermal hypervitaminotic A effects without systemic toxicity were produced in male albino rats injected intramuscularly with high doses of vitamin A palmitate. There was a loss of hair overlying the site of injection, accumulation of UV-fluorescent fat droplets in dermal and hypodermal macrophages and in the stratum Malpighi, intercellular epidermal edema, thickening of the stratum Malpighi and thinning of the stratum corneum. Subcutaneous administration of the same dose of vitamin A palmitate or intramuscular injection of vitamin A alcohol did not produce any skin lesions although morphologic examination of liver specimens from all the vitamin-treated animals revealed storage of vitamin A. Accumulation of the vitamin in macrophages in the dermis was always seen in specimens of skin overlying the site of intramuscular injection of vitamn A palmitate, suggesting that the changes in epidermis may be due to sustained release from this local intracellular store. Application of this method of parenteral administration of the esterified form of the agent will facilitate its use in studies of promotion or inhibition of tumorigenesis and in disorders of keratinization. PMID- 4326633 TI - Significance of cytoplasmic microtubules in lupus nephritis. AB - Twenty-five renal and three skin biopsies from 14 cases of systemic lupus erythematosus with lupus nephritis were examined by electron microscope. Seventy five renal biopsies from nonlupus cases consisting of 35 adults and 40 children were used for comparative study. Clusters of cytoplasmic microtubules, which have been referred to as virus-like particles, were observed in the endothelial cells of glomerular and peritubular capillaries in renal biopsies of all lupus cases. The clusters of microtubules were larger and more numerous in the initial biopsies with mild glomerular changes and in the second biopsies from two cases during a period of more severe relapse. Clusters of microtubules were fewer and smaller in renal biopsies with more advanced glomerular changes. Skin biopsies showed similar cytoplasmic inclusions in arterioles and capillaries. Cytoplasmic microtubules were also observed in 3 adults and 13 children of 75 patients who had no systemic lupus erythematosus. Although the formation of the cytoplasmic microtubules may be related to a virus infection, this suggestion cannot be confirmed from the morphologic findings of this study. Of additional interest is the evidence that these microtubules are not cytoplasmic changes secondary to corticosteroid therapy. It is concluded that the presence of many large clusters of cytoplasmic microtubules is specific for lupus nephritis, and it may be substantiated by similar findings in the skin. PMID- 4326632 TI - Lead toxicity: a problem in environmental pathology. PMID- 4326634 TI - Recovery of adrenal ultrastructure after cessation of androgen treatment. AB - Female, uninephrectomized rats injected with methylandrostenediol became hypertensive by 4 weeks of treatment. After cessation of treatment, blood pressure continued to rise during the first week but gradually decreased below the borderline of hypertension by 5 weeks. After methylandrostenediol treatment for 4 weeks and after 1 week of recovery, adrenocortical fine structure exhibited a number of abnormalities including reduced numbers of mitochondrial cristae, hypertrophic smooth endoplasmic reticulum, microfilaments and large lipid vacuoles within zona reticularis cells. During an intermediate period of recovery (2 weeks), mitochondrial cristae increased in number, although animals remained hypertensive. After 2 weeks, all of the ultrastructural abnormalities seen at early and intermediate periods of recovery were fully reversed, concomitant with a return of systolic blood pressure to below hypertensive levels. PMID- 4326636 TI - The determination of quartz on personal sampler filters by x-ray diffraction. PMID- 4326635 TI - The spleen in type I hyperlipoproteinemia. Histochemical, biochemical, microfluorometric and electron microscopic observations. AB - Histochemical, biochemical, microfluorometric and electron microscopic studies were made of the spleen of a patient with type I hyperlipoproteinemia. Foam cells were observed that contained a material identified as ceroid on the basis of its autofluorescence, acid-fastness, sudanophilia, PAS-positivity and insolubility in organic solvents. Electron microscopy showed that the ceroid was organized in the form of granules with concentric lamellae of irregular periodicity. The process of formation of these granules is described in detail. The ceroid was considered to represent nondigestible end products of the metabolism of chylomicrons taken up by macrophages in splenic sinusoids. PMID- 4326637 TI - Electron transport in phosphorylating mitochondria from Tetrahymena pyriformis strain ST. PMID- 4326638 TI - Mechanisms for the regulation of enzyme synthesis. PMID- 4326639 TI - Nitrite reductase-deficient mutants of Escherichia coli K12. PMID- 4326641 TI - To learn is to do. PMID- 4326640 TI - The concurrence of hydrocephalus and craniosynostosis. PMID- 4326642 TI - [Electroencephalography and heart rate in sleep of Macaca fuscata]. PMID- 4326643 TI - [Effect of psychotropic drugs on sleep and levels of wakefulness]. PMID- 4326644 TI - [Psychophysiological study of dreams]. PMID- 4326645 TI - [Memory during sleep]. PMID- 4326646 TI - [Changes of plasma growth hormone level in normal and hypersomnic patients during nocturnal sleep]. PMID- 4326647 TI - Certain components of the seminal fluid without the secretion of the seminal vesicle. PMID- 4326648 TI - [Epithelioma with altered stroma of the submaxillary gland]. PMID- 4326649 TI - The interaction of a spin-labeled sulfonamide with bovine carbonic anhydrase B. PMID- 4326650 TI - Effect of nitrogen dioxide on the activities of cytochrome oxidase and succinic dehydrogenase on homogenates of some organs of the rat. PMID- 4326651 TI - Inhibition of development of mammary tumors in C3H mice by neonatal administration of polycarboxylate. PMID- 4326652 TI - [Mammography. 3. Benign and malignant breast tumors]. PMID- 4326653 TI - Vitamin D: new findings on its metabolism and its role in calcium nutrition. PMID- 4326654 TI - [Herpesvirus]. PMID- 4326656 TI - [Summary of a systemic search for alpha-1-feto-protein in 224 hepatic diseases]. PMID- 4326660 TI - [Elements for an economic study of the cost of hospitalization]. PMID- 4326661 TI - [Optimal capacity of hospitals]. PMID- 4326664 TI - Radioactive cobalt treatment of glomus jugulare tumors. Clinical and angiographic investigation. PMID- 4326663 TI - Infectious mononucleosis. PMID- 4326665 TI - Glucagon? One answer to cardiogenic shock. PMID- 4326666 TI - Age susceptibility of chickens to Marek's disease. PMID- 4326667 TI - Effects of irradiation on avian leukosis. PMID- 4326668 TI - [Analogues of nucleoside polyphosphates. V. Action of adenosine-5'-hypophosphate on adenylate kinase and on pyruvate kinase. Preparation of adenosine 5' hypophosphate, a structural analogue of ATP]. PMID- 4326669 TI - Molecular orbital calculations on the conformation of nucleic acids and their constituents. I. Conformational energies of beta-nucleosides with C(3')-and C(2') endo sugars. PMID- 4326670 TI - Criticism of the use of methylated albumin-kieselguhr chromatography for the isolation of metabolically labile DNA. PMID- 4326672 TI - Prolonged curarization in a patient with renal failure. Case report. PMID- 4326671 TI - Properties of chromatin from liver and from a chemically induced minimal deviation hepatoma of the rat. PMID- 4326673 TI - Renal sarcoma. PMID- 4326674 TI - Cardiovascular responses to hypothalamic, spinal cord and stellate ganglion stimulation. PMID- 4326675 TI - A superior counting solution for water-soluble tritiated compounds. PMID- 4326676 TI - Determination of testosterone binding affinity, 17-beta-ol androgens, and free androgen index in hirsute women. PMID- 4326677 TI - [Trasylol, skeletal musculature and neuromuscular transmission]. PMID- 4326678 TI - Evidence for the role of collagenase in collagen metabolism. PMID- 4326679 TI - Sodium appetite and the renin-angiotensin system. PMID- 4326680 TI - Anion transport from the canine synovial cavity. PMID- 4326681 TI - Modern views on pharmacology. VII. Peripheral adrenergic systems. PMID- 4326682 TI - The etiology of hypertension. PMID- 4326683 TI - Renin, angiotensin and aldosterone in human pregnancy and the menstrual cycle. PMID- 4326684 TI - Physiologic, anatomic and pathophysiologic considerations of eye movements. PMID- 4326685 TI - Defects in supranuclear control of horizontal eye movements. PMID- 4326686 TI - Supranuclear abnormalities of the vertical ocular motor system. PMID- 4326687 TI - Difficulties in optic nerve and chiasmic compression. PMID- 4326688 TI - Herpes zoster ophthalmicus. PMID- 4326689 TI - [Enzyme histochemistry of bone tissue]. PMID- 4326690 TI - The separation of renal activity from lung and from the venous effluent from perfused lungs. AB - 1. Antidiuretic and salt-retaining activity has been separated from cat and ox lung, and from the venous effluent of blood-perfused cat lungs, by acetone extraction, gel filtration, partition and thin-layer chromatography.2. The chromatographic properties of the renally active substance from lung and from pulmonary venous blood are similar.3. The renal actions of these substances, demonstrable in vivo and in the isolated organ, are characterized by reduction in the excretion of water and Na. Renal blood flow, glomerular filtration rate and the urinary Na/K are not significantly affected.4. Concentrations of the lung substance which equate with angiotensin II-val(5)-amide in reduction of urinary Na in rats during water diuresis and under alcohol sedation do not raise the mean arterial pressure of the anaesthetized rat nor contract the superfused rat colon. At these dose levels angiotensin II is markedly vasopressor and contracts the superfused rat colon. PMID- 4326691 TI - Organizational structure, ideology and personality in psychiatric nursing. PMID- 4326692 TI - Mental hospitals--an obituary? PMID- 4326693 TI - The psychiatric nurse clinical specialist works with nursing service. PMID- 4326694 TI - An interruption in loneliness: the use of concrete objects in the promotion of human relatedness. PMID- 4326695 TI - Student evaluations of an interactional group experience. PMID- 4326696 TI - Non-specific complement fixation with Coxiella burnetii and psittacosis antigens in adenovirus pneumonia. PMID- 4326697 TI - Survival of enzyme activity in fresh sheep liver: a histochemical study. PMID- 4326698 TI - [Traumatic injuries of the brachial plexus in the infra-clavicular region]. PMID- 4326699 TI - [Early results of studies of the ultrastructure of chick embryo pancreas in tissue culture]. PMID- 4326700 TI - [60Cobalt-teletherapy of brain neoplasms]. PMID- 4326701 TI - Cortical circuitry underlying the mixed receptive fields of certain pyramidal tract neurons. PMID- 4326702 TI - Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 27-1971. PMID- 4326704 TI - N-hexane neuropathy. A syndrome occurring as a result of industrial exposure. PMID- 4326703 TI - Familial calcification of the basal ganglions: a metabolic and genetic study. PMID- 4326705 TI - Painful ophthalmoplegia and enophthalmos due to metastatic carcinoma: simulation of essential facial hemiatrophy. PMID- 4326706 TI - The medical uses of soft contact lenses. PMID- 4326707 TI - Post-operative follow-up study of trophoblastic tumors using radioimmunoassay for HCG and LH. PMID- 4326708 TI - The adrenal glands after epinephro-phlebography. PMID- 4326709 TI - [Paget's disease of the vulva]. PMID- 4326711 TI - [Cancer of the male breast]. PMID- 4326710 TI - [Enzymatically active stromal cells in ovarian tumours]. PMID- 4326712 TI - Alkyl acyl ethanolamine glycerophosphatides in rat intestinal mucosa. PMID- 4326713 TI - Congenital and acquired cytomegalovirus infections. PMID- 4326714 TI - Age determination and structural changes in calves. PMID- 4326715 TI - Physical activity after radical surgery for bronchial carcinoma. Relationship between clinical findings and pre-operative laboratory data. PMID- 4326716 TI - Grouping of enteroviruses according to their resistant cells. PMID- 4326717 TI - [Infectious bovine rhinotracheitis (IBR). Evidence of IBR virus in a calf with stomatitis erosiva]. PMID- 4326718 TI - [Acute Marek's disease of the chicken (literature review and original studies). 1. Disease concept, incidence, etiology and epizootiology)]. PMID- 4326719 TI - Evidence for the presence of tumor peptides with corticotropin-releasing-factor like activity in the ectopic ACTH syndrome. PMID- 4326720 TI - Inhibitors of DNA polymerases of murine leukemia viruses: activity of ethidium bromide. AB - Ethidium bromide, compared on a molar basis, was a more effective inhibitor of the DNA polymerases of the Rauscher and Moloney murine leukemia viruses than either 4-N-demethylrifampicin or 4-N-benzyldemethylrifampicin. Daunomycin inhibited the polymerases weakly, and chromomycin A(3) inhibited almost not at all. 4-N-Benzyldemethylrifampicin was a more active inhibitor than the 4-N demethyl congener. PMID- 4326721 TI - Calcium as a mediator of adrenocorticotrophic hormone action on adrenal protein synthesis. AB - Calcium stimulates leucine incorporation into protein during incubations of sections and cell-free preparations of the rat adrenal. Like adrenocorticotrophic hormone (ACTH) action, calcium enhances the transfer of amino acid from transfer RNA to protein. Stimulation of leucine incorporation by ACTH and cyclic adenosine monophosphate is best observed when sections are incubated in limiting calcium concentrations. PMID- 4326722 TI - [1st results of the study of ethylene diamine oxobornane sulfonate in virology]. PMID- 4326723 TI - [The ampulla of the vas deferens in goats]. PMID- 4326724 TI - [Biochemistry and physiological activity of phospholipids of phagocytic cells. I. Content and metabolic exchanges in normal leukocytes]. PMID- 4326725 TI - [Preservation of the producer of polymyxin M under laboratory conditions]. PMID- 4326726 TI - [Drug sensitivity of atypical Mycobacteria isolated from patients to antitubercular agents of the first and second order]. PMID- 4326727 TI - [Sensitivity to antibiotics of Shigella isolated in the city of Gorkii in 1966]. PMID- 4326728 TI - [Kanamycin and florimycin in the clinical course of pulmonary tuberculosis]. PMID- 4326729 TI - Methylation of transfer RNA by monkey liver and hepatoma induced by N nitrosodiethylamine. PMID- 4326730 TI - The progressive pressor response to angiotensin in the rabbit--the role of the sympathetic nervous system. PMID- 4326731 TI - [Redox enzyme activity of the liver during internal use of radon water]. PMID- 4326732 TI - [Chemical changes of some lysosome enzymes and cell death in herpetic infection]. PMID- 4326733 TI - [Evaluation of the use of highly sensitive methods of determining alpha fetoprotein for the diagnosis of hepatocellular cancer and teratoblastoma]. PMID- 4326735 TI - Clinical and pathological studies on pineal tumors. PMID- 4326734 TI - The interaction of corticosteroids and antimicrobial agents used in topical therapy. PMID- 4326737 TI - [Apropos of a case of splenic and pulmonary trophoblastic localization]. PMID- 4326736 TI - Biochemistry of depression. PMID- 4326738 TI - Possible role of the renin-angiotensin system in the regulation of antidiuretic hormone secretion. PMID- 4326739 TI - [Rehabilitation of patients following myocardial infarct and receiving polyclinical after care at the Department of Cardiology of the Clinic for Internal Diseases in Skopje]. PMID- 4326740 TI - Homology of ribosomal ribonucleic acid of Desulfovibrio species with Desulfovibrio vulgaris. AB - Three species of Desulfovibrio were found to have a high degree of ribosomal ribonucleic acid homology with Desulfovibrio vulgaris. Desulfotomaculum nigrificans, which is also a sulfate-reducing anaerobe, had only 38% ribosomal ribonucleic acid homology with D. vulgaris. The homologies of six other unrelated genera were determined and found to be lower than 50%. PMID- 4326741 TI - Isolation of vitamin B 12 transport mutants of Escherichia coli. AB - Escherichia coli KBT001, a methionine-vitamin B(12) auxotroph, was found to require a minimum of 20 molecules of vitamin B(12) (CN-B(12)) per cell for aerobic growth in the absence of methionine. After mutagenesis with N-methyl-N' nitro-N-nitrosoguanidine and penicillin selection, two kinds of B(12) transport mutant were isolated from this strain. Mutants of class I, such as KBT069, were defective in the initial rapid binding of CN-B(12) to the cell and were unable to grow in the absence of methionine even with CN-B(12) concentrations as high as 100 ng/ml. The class II mutants possessed intact initial phases of CN-B(12) uptake but were defective in the secondary energy-dependent phase. These strains were also unable to convert the CN-B(12) taken up into other cobalamins. In the absence of methionine, some of these strains (e.g., KBT103) were able to grow on media containing 1 ng of CN-B(12)/ml, whereas others (e.g., KBT041) were unable to grow with any of the CN-B(12) concentrations used. Osmotic shock treatment did not affect the initial rate of uptake of CN-B(12) but gave a substantial decrease in the secondary rate. Trace amounts of B(12)-binding macromolecules were released from the cells by the osmotic shock, but only from strains such as KBT001 and KBT041 which possessed an active initial phase of CN-B(12) uptake. These results are interpreted as being consistent with the view that the initial CN-B(12) binding site which functions in this transport system is probably bound to the cell membrane. PMID- 4326742 TI - Comparison of the phospholipid composition of Bifidobacterium and Lactobacillus strains. AB - Phospholipid composition of 10 Bifidobacterium strains of human intestinal origin and of 9 Lactobacillus strains was determined by quantitative two-dimensional thin-layer chromatography. Phospholipids of three Bifidobacterium strains from honey bees and of two strains from bovine rumen liquor were qualitatively investigated. Diphosphatidylglycerol and phosphatidylglycerol were present in strains of both genera. All Bifidobacterium strains contained as specific phospholipids a new polyglycerolphospholipid, compound 15, and its lyso derivatives, earlier detected in B. bifidum var. pennsylvanicus. Also, lyso compounds of diphosphatidylglycerol and alanyl phosphatidylglycerol were only present in this genus in variable amounts. Lysyl phosphatidylglycerol was the only ninhydrin-positive phospholipid in seven Lactobacillus strains. In L. delbruckii and L. helveticus it was absent and partially replaced by an unidentified ninhydrin-negative phospholipid. The differences in phospholipid composition between bifidobacteria and lactobacilli may be another argument to differentiate these two genera. PMID- 4326743 TI - Alkane oxidation by a particulate preparation from Candida. AB - The oxidation of decane by a cell-free particulate preparation from Candida intermedia was studied. Decane is oxidized to decanoate via decanol and decanaldehyde. Oxidation of decane to decanol requires molecular oxygen. Decanol is oxidized to decanaldehyde by a nicotinamide adenine dinucleotide-linked dehydrogenase differing greatly in specificity from ordinary yeast alcohol dehydrogenase. Decanaldehyde is oxidized to decanoate by a nicotinamide adenine dinucleotide-linked dehydrogenase that oxidizes long-chain aldehydes but not short-chain aldehydes. The enzymes that oxidize decane, decanol, and decanaldehyde are all induced when decane is present in the medium. These enzymes are apparently located in the cell membrane. PMID- 4326744 TI - Cell division and prophage induction in Escherichia coli: studies of nucleotide levels. AB - Cell division and prophage repression in the Escherichia coli mutant, T-44, are very sensitive to the levels of certain purine and pyrimidine derivatives in the media. The hypothesis that a change in the level of an adenine derivative in the small molecule pool of this strain was responsible for prophage induction and filament formation was tested. The nucleoside triphosphate pools in T-44 and C 600 nonlysogenic and lysogenic strains were labeled in experiments with (32)P and (33)P. Cultures were mixed, and the nucleotides were isolated. When adenine was present, the level of adenosine triphosphate (ATP) in T-44 compared to C-600 (as indicated by the isotope ratio) was increased up to twofold. Most of the other nucleotides increased but not to the same degree. In the lysogenic strain guanosine triphosphate and deoxycytidine triphosphate showed increases comparable to ATP, whereas increases noted in the deoxynucleotides in T-44 +/- lambda with adenine present were less. In experiments where T-44 and C-600 were incubated with (3)H- and (14)C-adenine, the levels of several compounds, including ATP, were slightly elevated in T-44. The combined data suggest that cultures of T-44 +/- lambda, grown in the presence of adenine, show a preferential increase in the level of ATP when compared to C-600 +/- lambda, but the increase in relation to the other nucleotides is less than twofold. In the experiment with (3)H- and (14)C-adenine, the level of inosine was found to be increased in T-44 relative to C-600. Cyclic AMP, when added to cultures of T-44 under various conditions, had no effect on prophage induction. Intracellular and extracellular levels of cyclic AMP in T-44 compared to C-600, incubated with had-acidin, guanosine, and cytidine (HGC) or with HGC plus adenine, were not significantly different. No compelling evidence for altered nucleotide metabolism in T-44 +/- lambda as a cause of prophage induction or filament formation was obtained. PMID- 4326746 TI - Negative disc exploration. An analysis of the causes of nerve-root involvement in sixty-eight patients. PMID- 4326745 TI - Corticosteroid-induced avascular necrosis. A clinical study of seventy-seven patients. PMID- 4326747 TI - [Pyridine nucleotides. I. Nicotinamide mononucleotide deamidase and a new pathway for "salvage synthesis" of nicotinamide adenine dinucleotide]. PMID- 4326748 TI - Effect of cyclic adenosine-3',5'-monophosphate on bone marrow delta aminolevulinic acid synthetase and erythrocyte iron uptake. PMID- 4326749 TI - Endotoxin-induced intravascular coagulation: prevention with polymyxin B sulfate. PMID- 4326750 TI - [Analytical chemical studies on steroids. XLV. Polarographic behaviors of androst 4-ene-3,6,17-trione]. PMID- 4326751 TI - Deoxyribonucleic acid polymerase of Rous sarcoma virus: studies on the mechanism of double-stranded deoxyribonucleic acid synthesis. AB - The deoxyribonucleic acid (DNA) polymerase of Rous sarcoma virus synthesizes both single- and double-stranded DNA, utilizing the ribonucleic acid (RNA) of the viral genome as the initial template. Results of pulse-chase experiments indicate that the single-stranded DNA serves as unconserved template and precursor for the synthesis of double-stranded DNA. The latter reaction is apparently initiated in association with the viral RNA and may involve a partially double-stranded intermediate form. PMID- 4326752 TI - Comparison of Rous sarcoma virus-specific deoxyribonucleic acid polymerases in virions of Rous sarcoma virus and in Rous sarcoma virus-infected chicken cells. AB - Labeled virions of Rous sarcoma virus (RSV) were disrupted with detergent and analyzed on equilibrium sucrose density gradients. A core fraction at a density of approximately 1.24 g/cc contained all of the (3)H-uridine label and about 30% of the (3)H-leucine label from the virions. Endogenous viral deoxyribonucleic acid (DNA) polymerase activity was only found in the same location. Additional ribonucleic acid (RNA)- and DNA-dependent DNA polymerase activities were found at the top of the gradients. RNA-dependent and DNA-dependent DNA polymerase activities were also found in RSV-converted chicken cells. Particles containing these activities were released from cells by detergent and were shown to contain viral RNA. These particles were analyzed on equilibrium sucrose density gradients and were found to have densities different from virion cores. PMID- 4326754 TI - Purification of the Sabin strain of poliovirus type I through treatment with sarkozyl. AB - Sodium dodecyl sulfate was found to aggregate virions from the Sabin Lsc2ab strain of poliovirus type 1. Aggregation was prevented by high ionic strength buffers. A procedure is described for the rapid purification of the virus through the use of sarkozyl. PMID- 4326753 TI - Structural polypeptides of simian virus 40. AB - To determine the number and molecular weights of the structural polypeptides of simian virus 40, we have analyzed purified virus by electrophoresis on 14% polyacrylamide gels containing sodium dodecyl sulfate. Full virus purified by several different methods showed six distinct bands with molecular weights of approximately 43,000 (VP1, containing 70% of virion protein), 32,000 (VP2, 9%), 23,000 (VP3, 10%), 14,000 (VP4, 6%), 12,500 (VP5, 4%), and 11,000 (VP6, 3%) both by analysis of radioactively labeled virions and by visualization of the polypeptide bands after staining. "Empty" virions contain decreased amounts of VP4, 5, and 6. The approximate molecular ratios of the polypeptides were 6.0, 1.0, 1.5, 1.5, 1.1, and 1.0. When virus degraded in an alkaline buffer was analyzed by velocity centrifugation in sucrose gradients, the two larger polypeptides (VP1 and VP2) remained at the top of the gradient, whereas the three smallest polypeptides (VP4, 5, and 6) sedimented as a complex with the viral deoxyribonucleic acid. VP3 was found in association with either VP1 and 2 or VP4, 5, and 6, depending on the conditions of degradation. Presumably, VP1 and VP2, comprising about 80% of the protein, form the capsid of the virus. VP4, 5, and 6 may form a nucleoprotein in the virion, and VP3 may serve as an intermediate structural component. PMID- 4326755 TI - [Renal embryoma in children]. PMID- 4326756 TI - [Perlingual indirect lymphography]. PMID- 4326757 TI - An approach to hypotonia in children. PMID- 4326758 TI - [Industrial hygiene of working places for quartz-glass blowers]. PMID- 4326759 TI - [Upper respiratory and digestive tract cylindroma: clinical data and treatment]. PMID- 4326760 TI - Fibrosarcoma. Report of sixty-four cases. PMID- 4326762 TI - Primary adenocarcinoma in cystic duct remnants. PMID- 4326761 TI - Benign surgical jaundice after right hepatic lobectomy for hepatoblastoma. PMID- 4326763 TI - Scleritis and rheumatoid arthritis. PMID- 4326764 TI - Local cortical blood flow during paradoxical sleep in man. PMID- 4326765 TI - Oscillatory potentials in the lateral geniculate nucleus during sleep and wakefulness. PMID- 4326766 TI - Structural properties of hydrogenase from Clostridium pasteurianum W5. PMID- 4326767 TI - Mechanism of alkylation of rabbit muscle glyceraldehyde 3-phosphate dehydrogenase. PMID- 4326768 TI - Adenylyl imidodiphosphate, an adenosine triphosphate analog containing a P--N--P linkage. PMID- 4326769 TI - Succinate dehydrogenase. I. Purification, molecular properties, and substructure. PMID- 4326770 TI - Succinate dehydrogenase. II. Enzymatic properties. PMID- 4326771 TI - Metabolism of benzoic acid by bacteria. Accumulation of (-)-3,5-cyclohexadiene 1,2-diol-1-carboxylic acid by mutant strain of Alcaligenes eutrophus. PMID- 4326772 TI - Electrophoretic analysis of the major polypeptides of the human erythrocyte membrane. PMID- 4326773 TI - Periodate oxidation of carbohydrate moiety of stem bromelain without much alteration in enzymatic activity. PMID- 4326774 TI - [Mechanism of the biological action of diazoketones]. PMID- 4326775 TI - Dermal cylindroma following x-ray epilation of the scalp. PMID- 4326776 TI - Ribonucleoside 2',3'-cyclic phosphate diesterase activity and cerebroside levels in vertebrate and invertebrate nerve. PMID- 4326777 TI - Studies on spermatogenesis in rats. II. Evidence that carnitine acetyltransferase is a marker enzyme for the investigation of germ cell differentiation. PMID- 4326778 TI - Phospholipase A2: action on purified phospholipids as affected by deoxycholate and divalent cations. PMID- 4326779 TI - Porcine sugar nucleotide: glycoprotein glycosyltransferases. I. Blood serum and liver sialyltransferase. PMID- 4326781 TI - Porcine sugar nucleotide: glycoprotein glycosyltransferases. 3. Blood serum and liver N-acetylglucosaminyltransferase. PMID- 4326780 TI - Porcine sugar nucleotide: glycoprotein glycosyltransferases. II. Blood serum and liver galactosyltransferase. PMID- 4326782 TI - The effect of the long-acting thyroid stimulator on the adrenal ascorbic acid of the mouse. PMID- 4326783 TI - Simultaneous determination of plasma converting enzyme and angiotensinase activity by radioimmunoassay. PMID- 4326784 TI - [Relation of the phospholipid composition of mitochondria and microsomes from hepatoma cells on the degree of malignancy of the tumor]. PMID- 4326785 TI - [Interaction between efferent and afferent excitations of motor cortex interneurons]. PMID- 4326786 TI - Induction of an ovarian epimerase system catalyzing the transformation of 5-alpha androstane-3-alpha, 17-beta-diol to 5-alpha-androstane-3-beta, 17-beta-diol after treatment of immature rats with gonadotrophins exhibiting FSH-like activity. PMID- 4326787 TI - Effects of in vivo and in vitro administered thyroxine on substrate metabolism of isolated rabbit ventricle mitochondria. 3. Substrate effects on pyridine nucleotide reduction, on the reversal of electron transport, and on the "respiratory control by ATP". PMID- 4326788 TI - Flavin nucleotide coenzyme biosynthesis and its relation to corticosteroidogenesis in the rat adrenal. PMID- 4326789 TI - Effect of colchicine on in vitro ACTH release induced by HIGH K+ and by hypothalamus-stalk-median eminance extract. PMID- 4326790 TI - Effects of hypophysectomy and administration of cortisone or ACTH on adrenal 5 alpha-reductase activity and steroid production. PMID- 4326791 TI - Pineal gland in organ culture. II. Role of adenosine 3',5'-monophosphate in the regulation of radiolabeled melatonin production. PMID- 4326792 TI - ACTH secretion due to hypothalamo-pituitary effects of adenosine 3',5' monophosphate and related substances. PMID- 4326793 TI - Adrenal steroids and the maintenance of a circadian distribution of paradoxical sleep in rats. PMID- 4326794 TI - Effects of gonadal hormones and ACTH on the nature and rates of secretion of adrenalcortical steroids by the rat. PMID- 4326796 TI - [Herpes gestations]. PMID- 4326795 TI - Simultaneous effects of thyroid and adrenal inhibitors on maternal-fetal endocrine interrelations in the rat. PMID- 4326797 TI - [Developments in the renin-angiotensin system]. PMID- 4326798 TI - A simple method for coupling proteins to insoluble polysaccharides. PMID- 4326799 TI - Twenty-four hour pattern of the episodic secretion of cortisol in normal subjects. PMID- 4326800 TI - Inhibition of lipolysis and potentiation of the hypoglycaemic effect of insulin by non-hypoglycaemic insulin derivatives. PMID- 4326801 TI - The aldosterone secretory response to sodium restriction in chronically hypophysectomized corticotrophin-maintained rats as a function of duration and amount of growth hormone treatment. PMID- 4326802 TI - Effects of demineralization and parathyroid hormone on the availability of bone collagen to degradation by collagenase. PMID- 4326803 TI - Responses of renal mechanoreceptors to vasopressor substances. PMID- 4326804 TI - [Alpha 1 fetoglobulin and hepatoma]. PMID- 4326805 TI - Effects of 5'-AMP and its related compounds on the ATP-induced contraction of isolated guinea-pig ileum. PMID- 4326806 TI - [Corticotherapy in infantile hematology]. PMID- 4326807 TI - [Biological bases of corticosteroid treatment in neurological diseases in childhood]. PMID- 4326808 TI - [The collateral effects of prolonged corticosteroid therapy]. PMID- 4326809 TI - Double stranded RNA from rat liver induces interferon in rat cells. PMID- 4326810 TI - Inhibitors of the RNA and DNA dependent polymerase activities of RNA tumour viruses. PMID- 4326811 TI - Human-mosquito somatic cell hybrids induced by ultraviolet-inactivated Sendai virus. PMID- 4326812 TI - Increase of brain tryptophan caused by drugs which stimulate serotonin synthesis. PMID- 4326813 TI - Induction of long term lymphocyte lines from delayed hypersensitive human donors using specific antigen plus Epstein-Barr virus. PMID- 4326814 TI - Subcellular localization of angiotensin I converting enzyme in rabbit lung. PMID- 4326815 TI - Correction of a genetic defect in a mammalian cell. PMID- 4326816 TI - [Studies on the digital computer processing of the radioisotope image through the scinticamera]. PMID- 4326817 TI - [A kit system for the preparation of indium- 113 m-In EDTA and its application to brain scanning]. PMID- 4326818 TI - [An anatomo-clinical and therapeutic study of alveolobronchiolar carcinoma]. PMID- 4326819 TI - [Clinical aspects of primary hepatoma in children]. PMID- 4326820 TI - Detection of an ACTH-secreting bronchial carcinoid tumour eighteen months after adrenalectomy for Cushing's syndrome. PMID- 4326821 TI - Adrenocortical response to ethanol in mice: modification by chronic ethanol consumption. PMID- 4326822 TI - Studies on the transformation of human fetal cell cultures by simian virus 40. PMID- 4326823 TI - Hypothalamic control of the secretion of adenohypophysial hormones. PMID- 4326824 TI - Human adipose tissue dynamics and regulation. PMID- 4326825 TI - The relationship between angiotensin and aldosterone. PMID- 4326826 TI - [Control of purity of different preparations of rat cardiac myosin by disk electrophoresis with a view toward obtaining a pure antigen]. PMID- 4326827 TI - Thermal stability of horse liver alcohol dehydrogenase and its complexes. PMID- 4326829 TI - The formation of ternary complexes by diphosphopyridine nucleotide-dependent dehydrogenases. PMID- 4326828 TI - Some properties of reactions catalyzed by pig brain NAD glycohydrolase. PMID- 4326831 TI - Nuclear localization of diguanosine polyphosphates in Artemia embryos. PMID- 4326830 TI - Polypeptide biosynthesis form thioesters of amino acids. PMID- 4326832 TI - Yeast phosphofructokinase: effector-controlled conversion of an ATP-sensitive to an ATP-desensitized form. PMID- 4326834 TI - Flow flash kinetics of the cytochrome a 3 -oxygen reaction in coupled and uncoupled mitochondria using the liquid dye laser. PMID- 4326833 TI - Active and inactive forms of pyruvate dehydrogenase in rat heart and kidney: effect of diabetes, fasting, and refeeding on pyruvate dehydrogenase interconversion. PMID- 4326835 TI - Transplantable malignant cholangiocarcinoma from hamster liver. PMID- 4326836 TI - Experimental acute pulmonary edema in the rat. Effect of Bordetella pertussis vaccine on ozone mortality. PMID- 4326837 TI - Studies on lymphocytes 18. Mechanism of lymphocytosis induced by supernatant fluids of Bordetella pertussis cultures. PMID- 4326838 TI - In vitro induction of myeloid proliferation and maturation in infantile genetic agranulocytosis. PMID- 4326839 TI - The effect of an antibiotic spray in the prevention of wound infection. A controlled trial. PMID- 4326840 TI - Femoral and sciatic compression neuropathy. PMID- 4326841 TI - Misleading features in the clinical diagnosis of the peripheral glomus tumour. PMID- 4326842 TI - Oat-cell bronchial carcinoma and catecholamine production. PMID- 4326843 TI - [Mouse mammary tumor virus (MTV). Experimental study of the structure of the extracellular stages. General interpretation of the viral cycle]. PMID- 4326845 TI - [Physiology and pathology of steroid hormones in childhood]. PMID- 4326844 TI - [Steroid hormone forming tissue]. PMID- 4326846 TI - Baroreceptor reflex function in pre-eclampsia. PMID- 4326847 TI - Endocrine studies in post-menopausal women with ovarian tumours. PMID- 4326848 TI - Effects of cold, eating, efferent nerve stimulation and angiotensin on heart rate in sheep before and after autonomic blockade. AB - 1. Effects of the natural stimuli of cold exposure and feeding on heart rate were tested in conscious sheep in which blockade of the cardiac efferent nerves was achieved by administration of propranolol and atropine. Effects of direct nerve stimulation, isoproterenol and angiotensin on heart rate before and after autonomic blockade were studied in acute preparations anaesthetized with pentobarbitone sodium.2. Propranolol reduced the extent of cardioacceleration induced both by exposure to cold and by eating. Heart rate in propranolol treated animals exposed to cold did not exceed about 120 beats/min. During eating, heart rate in propranolol treated animals showed no upper limit and increased on occasions to over 170 beats/min.3. Heart rate in conscious sheep following administration of atropine and propranolol was about 110 beats/min; in anaesthetized sheep following vagal section and propranolol it was usually about 120 beats/min. This was taken as intrinsic heart rate.4. Angiotensin administered to normal anaesthetized sheep usually reduced heart rate. After vagal section and propranolol, angiotensin injection usually, and angiotensin infusion invariably, increased heart rate.5. It was concluded that there exists in sheep a mechanism which during eating elevates heart rate by a means other than through the parasympathetic and sympatho-adrenal systems. It is suggested that this mechanism involves a direct chronotropic effect of angiotensin secreted in association with eating. PMID- 4326849 TI - On the presynaptic acetylcholine receptors in sympathetic ganglia of the frog. AB - 1. Action potentials have been recorded extracellularly from individual preganglionic nerve terminals in the lumbar sympathetic chain of frogs (cf. Koketsu & Nishi, 1968).2. The action potentials were unaffected by changes in external Mg(2+) or Ca(2+) concentration, but were attenuated or even abolished by acetylcholine or carbachol. The effect on the presynaptic action potential was transient, in contrast to the blockade of synaptic transmission caused by these drugs, which as is well known persists indefinitely in their presence.3. In the presence of tubocurarine (5 x 10(-5)M), acetylcholine and carbachol had no effect on the presynaptic action potential.4. The action potentials were reduced by an increase in external K(+) concentration and abolished at between 9 and 16 mM K(+). Synaptic transmission persisted until the amplitude of the action potential was reduced to less than one third of its control value.5. It is concluded that although the presynaptic nerve is endowed with acetylcholine receptors, they are not the source of the long lasting blockade of synaptic transmission caused by cholinergic substances. PMID- 4326850 TI - Sex differences in the changes in sympathetic nerve activity when arterial pressure is raised by infusion of angiotensin and noradrenaline. AB - 1. In cats and dogs impulse frequency was studied in single and few-fibre preparations of the cervical sympathetic nerves when blood pressure was raised in steps to about 200 mm Hg by infusions of noradrenaline and angiotensin. Two forms of frequency/blood pressure relationships were found which differed in their distribution between the sexes.2. In females, both normal and ovariectomized, there was an inverse linear relationship between spike frequency and blood pressure over the whole range of blood pressure studied. The same was true in castrated males and normal males pretreated with oestrogens.3. In normal males the inverse linear relationship held to a pressure of about 150 mm Hg. At higher pressures the sympathetic discharge rate remained steady or increased. This was also found in castrated males pretreated with testosterone. There was a statistically significant difference between the responses of these animals and those of normal females and castrated or oestrogen treated males.4. The sex difference originates peripherally since the responses of both sexes were similar following baroreceptor and chemoreceptor denervation. During ventilation with oxygen instead of air the male pattern of response becomes like that of the female. The latter observation implicated the chemoreceptors.5. alpha adrenoceptor blockade with phenoxybenzamine and phentolamine localized to the region of the carotid bifurcation in male cats abolished the increase in sympathetic discharge rate at high blood pressure induced by noradrenaline, but did not alter the response to angiotensin.6. Records of spike frequency in single and few-fibre preparations of chemoreceptor units in the sinus nerves of cats also showed an inverse relationship between frequency and blood pressure in females. In males at the higher pressures, the discharge rate was steady or increased. The increased chemoreceptor discharge at high pressures in males was abolished by ventilation with oxygen instead of air.7. The sex difference in behaviour of chemoreceptor units could not be explained by differences in either total carotid body blood flow or arterial oxygen tension.8. It is tentatively concluded that the observed sex difference is related to the state of the blood supply to the chemoreceptors and that, in males, testosterone sensitizes the blood vessels to vasoconstrictors, so that at high pressures blood is diverted through shunts and the chemoreceptors are subjected to a stagnant hypoxia. PMID- 4326851 TI - Synaptic transmission in the superior cervical ganglion of the cat after reinnervation by vagus fibres. AB - 1. A vagus-sympathetic anastomosis was performed in the cat by connecting end to end the cranial trunk of the vagus to the cranial end of the cervical sympathetic trunk, both severed under the ganglia.2. Forty to sixty days after the anastomosis, the ocular signs of sympathetic paralysis (such as myosis and prolapse of the nictitating membrane) which had developed shortly after the operation, had completely disappeared, thus suggesting the recovery of synaptic transmission in the ganglion. In case of plain preganglionic denervation after the same period the ocular signs of cervical sympathetic paralysis were still present.3. Contraction of the nictitating membrane could be induced by electrical stimulation of both the vagus preanastomotic and the sympathetic postanastomotic preganglionic trunks. Ganglionic blocking agents induced the blockade of the ;new' ganglionic synaptic function, while nicotine and pilocarpine provoked a marked contraction of the nictitating membrane.4. Electron microscopy showed that the preganglionic regeneration of vagus fibers resulted in the formation of new synapses, mainly of axodendritic type, identical to normal ganglionic synapses. Moreover, after cutting the preanastomotic trunk of the vagus, these new ganglionic presynaptic profiles degenerated, thus proving their vagal origin.5. During restoration of the synaptic contacts readjustment of dendritic tips occurred. PMID- 4326852 TI - [Histochemical studies on the degranulation of the mast cell]. PMID- 4326853 TI - Determination of the hemolytic activity of Vibrio cholerae. PMID- 4326854 TI - The biologically relevant parameter in nerve impulse trains. PMID- 4326855 TI - The transformation induced by light stimulus on the retinal discharge: study of the interval distribution at high frequencies of sinusoidal stimulation. PMID- 4326857 TI - Cosyntropin (synthetic corticotropin). PMID- 4326856 TI - Signal stabilization and noise suppression in neural systems. PMID- 4326858 TI - Effect of renal transplantation on the function of the peripheral nervous system. PMID- 4326859 TI - Reflections on Cushing's syndrome. PMID- 4326860 TI - Reaction of aminoacyl-tRNA synthetases with heterologous tRNA's. PMID- 4326862 TI - Encephalomyelitis of swine caused by a haemagglutinating virus. VI. Morphology of the virus. PMID- 4326861 TI - Liporibonucleoprotein as an integral part of animal cell membranes. PMID- 4326863 TI - The multiplication of Talfan virus in pig intestinal organ cultures. PMID- 4326864 TI - The effect of enterotoxigenic Clostridium welchii (perfringens) type A on the bovine intestine. PMID- 4326865 TI - Two-plaque-size variants of foot-and-mouth disease virus differing in neutralization by guinea-pig antisera. PMID- 4326867 TI - [Localization of nerve damage in idiopathic facial paresis and the question of decompression]. PMID- 4326868 TI - Oscillopolarographic determination of cysteic acid level in the fingernails followed chronic irradiation in humans. PMID- 4326869 TI - [Morphokinetic effect of thyrotrope hormone on the C-cells of the thyroid gland]. PMID- 4326870 TI - [Creatinine elimination rate as reference value for analysis of urine samples. I. Effect of daily urine volume and circadian rhythm on creatinine excretion]. PMID- 4326871 TI - Carcinoma of the ovary and endometriosis. PMID- 4326872 TI - [Antibiotherapy and renal insufficiency]. PMID- 4326873 TI - [On phosphatase activity at the level of the spinal ganglion in Maccacus Rhesus]. PMID- 4326874 TI - [Histochemistry of the islands of Langerhans in the pancreas of the sheep (ovis aries)]. PMID- 4326875 TI - [Polymyxin M synthesized by Bacillus polymyxa var. Ross under different conditions of cultivation]. PMID- 4326876 TI - [On the so-called granular cell myoblastomyoma. Apropos of an unusual biopsy case with juxta-anal site]. PMID- 4326877 TI - Interaction of nicotinamide-adenine dinucleotide and its analogs with glyceraldehyde 3-phosphate dehydrogenase. PMID- 4326878 TI - Relation of the auramine O binding site to the active site of horse liver alcohol dehydrogenase. PMID- 4326879 TI - Threonine-sensitive aspartokinase-homoserine dehydrogenase of Escherichia coli K 12. Reaction with 6-mercapto-9- -D-ribofuranosylpurine 5'-triphosphate. PMID- 4326880 TI - Regulation of succinate dehydrogenase activity by reduced coenzymes Q10. PMID- 4326881 TI - Characterization of sea urchin ribosomal satellite deoxyribonucleic acid. PMID- 4326882 TI - Isolation and chemical properties of porcine parathyroid hormone. PMID- 4326883 TI - Isolation and identification of 1,25-dihydroxycholecalciferol. A metabolite of vitamin D active in intestine. PMID- 4326884 TI - Dipole moment of acetylcholine and its relevance to the chemical synaptic transmission. AB - The dipole moment of acetylcholine (AcCh) has been measured in chloroform and a value of 8.49 D was obtained. Such a value actually represents the total dipole moment of the ion pair (AcCh)(+)(Cl)(-). The dipole moment of the (AcCh)(+) cation alone turned out to be 2.65 D whereas its theoretical value obtained after a vectorial calculation was 1.65 D. The discrepancy was related to an interaction between AcCh and the solvent. The meaning of the measured value is discussed on the basis of a recent theory of chemical synaptic transmission based on the assumption of a much higher dipole moment value for the AcCh molecule. PMID- 4326885 TI - Advanced carcinoma of the maxillary antrum treated by cobalt teletherapy and electron beam irradiation. PMID- 4326886 TI - Angiography in carcinoma of the biliary tract. PMID- 4326887 TI - Cardiac catecholamine synthesis, turnover, and metabolism with isoproterenol induced myocytolysis. PMID- 4326889 TI - Nervous system manifestations of cytomegalovirus (CMV) infection. PMID- 4326888 TI - [Malignant degeneration of Spiegler's tumor]. PMID- 4326890 TI - [Microangiopathic hemolytic anemia in metastasizing carcinoma of the stomach]. PMID- 4326891 TI - [Therapy of cervix cancer]. PMID- 4326892 TI - [Characteristics of myositis in electromyography]. PMID- 4326893 TI - Inverse variations of plasma renin activity and renin substrate in normal man. PMID- 4326894 TI - Some clinical and therapeutic aspects of the nephrotic syndrome in the adult (with special emphasis on the effects of indomethacin and related substances). PMID- 4326895 TI - Two cases of hydatidiform degeneration of the placenta with fetal abnormality and triploid chromosome constitution. PMID- 4326896 TI - Actinomycin D in the treatment of methotrexate-resistant malignant trophoblastic tumours. PMID- 4326897 TI - The replication of the ring-shaped DNA of polyoma virus. II. Identification of molecules at various stages of replication. PMID- 4326898 TI - Lipid spin labels in lecithin multilayers. A study of motion along fatty acid chains. PMID- 4326899 TI - A mode control model of a neuron's axon and dendrites. PMID- 4326900 TI - [Examination of angiotensin in hypertension]. PMID- 4326901 TI - [Bridging of peripheral nerve defects with lyophilised and disantigenised homologous grafts]. PMID- 4326902 TI - Aseptic meningitis in association with herpes progenitalis. PMID- 4326903 TI - [Case of metastatic cancer of the temporal bone simulating acoustic nerve tumor]. PMID- 4326905 TI - [Diseases of the external female genitalia. Hidradenoma papilliferum (Adenoma hidradenoides. Hidradenoma tubulare)]. PMID- 4326904 TI - [Neurological syndromes as remote effect of malignant tumors]. PMID- 4326906 TI - [Experiences with the local treatment of seriously burned patients due to disasters]. PMID- 4326907 TI - Studies on the influence of host defence mechanisms on the antimicrobial effect of chemotherapeutic agents. Effect of antibiotics on phagocytosis of mouse peritoneal-macrophages in vitro. PMID- 4326908 TI - Chromosomes in bronchial adenomas and in bronchogenic carcinomas. PMID- 4326909 TI - [The myoepithelial component in the histogenesis of the so-called mixed tumors of the salivary glands]. PMID- 4326910 TI - [Structural and functional changes in reactivating cells of Nitrobacter winogradskyi Buch]. PMID- 4326911 TI - [Stereochemistry of the transfer of hydrogen on analogues of NAD+]. PMID- 4326912 TI - Genital herpes infection and non-specific urethritis. PMID- 4326913 TI - [Immunological study of the sub-types of aphthous virus. Principle; method; use]. PMID- 4326914 TI - [Practical evaluation of the role of vaccine and serum in the prevention of aphthous fever in swine]. PMID- 4326915 TI - Respiration and oxidative phosphorylation by mitochondria of red and white skeletal muscle. PMID- 4326916 TI - The chemical constitution of lipid A from Serratia marcescens. PMID- 4326917 TI - Utilization of glycerophosphate for phospholipid synthesis by cells of Halobacterium cutirubrum. PMID- 4326918 TI - Reduction of nonheme iron in the respiratory chain of Escherichia coli. PMID- 4326919 TI - Aflatoxicol: structure of a new transformation product of aflatoxin B 1. PMID- 4326921 TI - Catheterization of the umbilical vein and its use for hepatography. PMID- 4326922 TI - A trial of intra-lymphatic cyclophosphamide in patients with arm lymphoedema due to metastatic breast carcinoma. PMID- 4326920 TI - Prolonged administration of antithymocyte serum in mice. II. Histopathological investigation. PMID- 4326924 TI - [VER of the intracranial lesion and its clinical evaluation]. PMID- 4326923 TI - [Nacolepsy an its therapy]. PMID- 4326925 TI - [Influence of various drugs on liver glycogen and blood sugar levels in reserpinized rats. Combined effect of MAOI, 5HTP, DOPA, ACTH and cortisone]. PMID- 4326926 TI - The effect of hypothalamic lesions and hypophysectomy on adrenal weight in Sceloporus cyanogenys. PMID- 4326927 TI - [New development of sebaceous glands over histiocytomas]. PMID- 4326928 TI - [Clinical aspects and therapy of mycosis fungoides]. PMID- 4326929 TI - Microfluorimetric study of drug induced metabolic adaptations. PMID- 4326930 TI - Factors affecting longevity in unselected patients on maintenance hemodialysis. PMID- 4326931 TI - Presence of serologically distinct protein in serum of cancer patients and pregnant women. An attempt to develop a diagnostic cancer test. PMID- 4326932 TI - Metabolic properties of mouse transplantable adenocarcinoma. II. Substrate utilization by homogenates. PMID- 4326933 TI - Electron microscopic study on acute thymic involution induced by polyoma virus infection. PMID- 4326934 TI - Dependence of chromosome pulverization in virus-fused cells on events in the G2 period. PMID- 4326935 TI - Cytoplasmic inclusion bodies in primary and transplanted hepatomas of mice of different strains. PMID- 4326936 TI - Replication of mammary tumor virus in tumor cell cultures: dependence on hormone induced cellular organization. PMID- 4326937 TI - Initiation and establishment of lymphoid cell lines from the blood of healthy persons. PMID- 4326938 TI - Cell line initiation from cord blood leukocytes treated with viruses, chemicals, and radiation. PMID- 4326939 TI - Alveolar macrophages. Structural and functional differences between nonsmokers and smokers of marijuana and tobacco. PMID- 4326940 TI - Morphologic and biochemical changes in smooth muscle cells of aortas in growth restricted rats. PMID- 4326941 TI - Papova-like virus particles in a human brain tumor. PMID- 4326942 TI - Entero-Vioform and organic neurologic disease. PMID- 4326943 TI - [Distinction between myogenic, peripheral neurogenic and central pareses in general practice]. PMID- 4326944 TI - [Clinical aspect of cytomegaly in children and adults]. PMID- 4326945 TI - Calcifications in gastrointestinal malignancy--an important clue in radiologic diagnosis. PMID- 4326946 TI - [Mixed salivary gland tumour of the trachea]. PMID- 4326947 TI - [Verner-Morrison-Syndrome. A case report]. PMID- 4326948 TI - Pharmacology of lipid metabolism. Introductory remarks. PMID- 4326949 TI - Biological significance of prostaglandins with special reference to their effects on metabolism. PMID- 4326950 TI - Drugs affecting lipolysis. PMID- 4326951 TI - Influence of the molecular organization on radical yield of organic compounds. PMID- 4326952 TI - Dose dependence of the transfer of radiation-induced free radicals from DNA to cysteamine. PMID- 4326953 TI - [Primary linitis plastica of the colon]. PMID- 4326954 TI - [Effect of 5-fluorouracil on protein metabolism of tumors and normal tissues in culture]. PMID- 4326955 TI - [Liver and lung tumors following 3,3'-dichloro-4,4'-diamino-diphenylmethane in rats]. PMID- 4326956 TI - The interaction of SV40 with SV40-transformed and non-transformed monkey kidey cells. PMID- 4326958 TI - Fine structure of the corpus luteum of the raccoon during pregnancy. PMID- 4326957 TI - [Glucose-6-phosphatase and aldolase in primary liver tumors induced by diethylnitrosamine]. PMID- 4326959 TI - [Effect of melatonin treatment on growth of Walker carcinosarcoma in rats]. PMID- 4326960 TI - [Lung carcinoma in cases of chronic pulmonary fibrosis]. PMID- 4326961 TI - [Protoplasmic inclusions in malignant epithelial tumors]. PMID- 4326963 TI - [Mixed tumor of the submandibular gland]. PMID- 4326962 TI - [Bilateral Mullerian mixed tumor of the ovary]. PMID- 4326964 TI - Thrombocytopenia in Gaucher's disease. PMID- 4326965 TI - [Clinical trial of daunomycin in gynecological oncology]. PMID- 4326966 TI - [Molecular mechanisms of the utilization of information by the brain]. PMID- 4326967 TI - [The susceptibility of chicks, previously treated with myelocytomatosis material, to erythroblastosis virus (strain R)]. PMID- 4326968 TI - [Production of concentrated and purified antigen from bovine para-influenza-3 virus]. PMID- 4326969 TI - Nuclear membranes from mammalian liver. 3. Fatty acids. PMID- 4326971 TI - Purification and characterization of (Na+ + K+)-ATPase. II. Preparation by zonal centrifugation of highly active (Na+ + K+)-ATPase from the outer medulla of rabbit kidneys. PMID- 4326970 TI - Preparation and properties of plasma membrane and endoplasmic reticulum fragments from isolated rat fat cells. PMID- 4326972 TI - On the specificity of the ATP-binding site of (Na+ + K+)-activated ATPase from brain microsomes. PMID- 4326973 TI - Effect on p-nitrophenyl phosphate on the short-circuiting current in the turtle bladder. PMID- 4326974 TI - [Trophoblastomas: their surveillance and treatment with methotrexate, actinomycin D and folinic acid]. PMID- 4326975 TI - [Mulleroblastomas. Apropos of 2 cases]. PMID- 4326977 TI - [Comparative action of hydrocortisone and cyclic AMP on the multiplication of cells in culture (strain KB) and their survival after ultraviolet irradiation]. PMID- 4326976 TI - [Study of a treponema strain isolated from a case of yaws in Ivory Coast]. PMID- 4326978 TI - [Influence of electric stimulation on the incidence of intranuclear rods of sympathetic neurons. Quantitative study by electron microscopy]. PMID- 4326979 TI - [Action of aldehydic atmospheric pollutants, on the NAD-NADH system of liver, lung and brain, in the rat]. PMID- 4326980 TI - [Mammography as a method for early diagnosis of female breast cancer. Experiences with a screening test in 7380 apparently healthy women]. PMID- 4326981 TI - [Glandular cell types and localisation of hormones in the pituitary gland anterior lobe]. PMID- 4326983 TI - [Adrenal function in urological patients]. PMID- 4326982 TI - [Electrodiagnostic findings in local tetanus in man]. PMID- 4326984 TI - [Correlations between extra-hypothalamic cerebral lesions and function tests of the ACTH secreting system]. PMID- 4326985 TI - Surgery--ancient and modern. PMID- 4326986 TI - [Lichen amyloidus in generalized pericollagenic amyloidosis and plasmacytoma, coincidence of epithelioma adenoides cysticum Brooke and Spiegler tumors]. PMID- 4326987 TI - [Clinical aspects and therapy of virus diseases of the oral cavity]. PMID- 4326988 TI - Problems in the management of synovial sarcoma. PMID- 4326990 TI - Detection of tumor-specific cell surface antigen of simian virus 40-induced tumors by the isotopic antiglobulin technique. PMID- 4326989 TI - Antibody to human cell lines with and without ultrastructural evidence for Epstein-Barr virus (EBV) infection in sera from patients with diverse viral illnesses. PMID- 4326991 TI - Histochemistry of giant cells in tumours induced in golden hamsters by murine sarscoma virus-Harvey. PMID- 4326992 TI - Ribosomal RNA in avian leukosis virus particles. PMID- 4326993 TI - Cell-mediated and humoral immune responses to tumor-associated and viral antigens in relation to the pathogenic effect of Rous sarcoma virus in rats. PMID- 4326994 TI - Infection and transformation of mouse peritoneal macrophages by simian virus 40. AB - The stimulation of DNA synthesis in mouse (C57BL) macrophages explanted in vitro was demonstrated after treatment with conditioned medium or infection with SV40. In the latter case, induction of SV40 T antigen was detected before TdR-(3)H incorporation. Even though all macrophages were infected (T antigen-positive), they exhibited considerable pleomorphism, accompanied by functional differences. Permanent lines of SV40-transformed macrophages were eventually established, and one clone was isolated which replicates indefinitely and has many properties of primary macrophages: high acid phosphatase and phagocytic activity, lysozyme production, and specific antigenic determinants. These cells differ from normal macrophages in that they contain the SV40 genome, can be trypsinized, and do not require conditioned medium for continued replication. PMID- 4326995 TI - The effects of hypercapnia, hypoxia and ventilation on the baroreflex regulation of the pulse interval. AB - 1. The effects of moderate degrees of hypercapnia in hypoxia and in hyperoxia on the baroreceptor-cardiodepressor reflex have been studied in nine normal men.2. The beat-by-beat relation between pulse interval (I) and systolic pressure (P) during transient elevations of arterial pressure induced by intravenous injections of angiotensin II and phenylephrine was used to assess the sensitivity (DeltaI/DeltaP) and setting (I at a single reference arterial pressure) of the reflex.3. There was no consistent change in reflex sensitivity in any of the conditions studied.4. In hyperoxia (P(A, O2) approximately 200 torr) hypercapnia was associated with significant re-setting of the reflex in the direction of tachycardia. The extent of the re-setting was correlated with the degree of hypercapnia and with the accompanying increase in breathing.5. When hyperoxia with hypercapnia was replaced by hypoxia (P(A, O2) approximately 55 torr) with hypercapnia (which causes substantial arterial chemoreceptor activity), pulse interval at constant arterial pressure was further decreased.6. The tachycardia of hypoxia could not be accounted for by change of arterial pressure, P(A, CO2) or pulmonary ventilation, since it was most clearly demonstrable at constant values of pressure and either P(A, CO2) or ventilation. PMID- 4326996 TI - Age changes in cross striated muscle of the rat. AB - 1. Senile muscle atrophy is characterized by a marked reduction in the frequency of spontaneous transmitter release with no electrophysiological evidence of denervation.2. In spite of the reduced number of muscle fibres, there is no ultrastructural evidence for denervation at the end-plates. There is agglutination of synaptic vesicles, neurotubules and filaments, thickening of the basement membrane, widening of the primary synaptic cleft, and irregular branching of the junctional infoldings, but no axonal degeneration.3. The contractile process in senile muscles is slowed down as is indicated by a prolongation of contraction time, latency period, maximum rate of twitch tension and relaxation time.4. The muscle fibres show proliferation of the T system and increased SR but no fragmentation as is observed in denervation atrophy.5. Senile muscle atrophy thus presents some specific features affecting both pre- and post synaptic structures, related to a very slow process of deterioration of the neuromuscular contact. PMID- 4326997 TI - The effect of prolonged depolarization on synaptic transfer in the stellate ganglion of the squid. AB - 1. Depolarization of the giant axon terminal of the squid causes local calcium influx which gives rise to transmitter release and post-synaptic response, and which under certain experimental conditions leads to a regenerative action potential in the presynaptic terminal itself.2. There has been conflicting evidence in the literature on the question whether the calcium permeability change in the terminal is rapidly inactivated, or whether it can persist with little diminution for hundreds of milliseconds during a depolarizing voltage step.3. Results are presented which show that there is little ;calcium inactivation', even when very large depolarizing steps are imposed on the terminal and maintained for periods of 1-2 sec.4. Contrary indications are examined and found to be attributable to an increase of potassium conductance, rather than direct inactivation of calcium conductance. PMID- 4326999 TI - Evidence in favour of a fast feed-back control of ACTH secretion by corticosterone. PMID- 4326998 TI - Evidence suggesting uptake of noradrenaline at adrenergic receptors in the isolated blood-perfused cat spleen. PMID- 4327000 TI - [Cyclic adenosine-3',5'-monophosphate (cyclic AMP). General principle of the information transmission between the hormone and metabolism in the cell]. PMID- 4327001 TI - Serologic evidence that a herpes-type virus is the etiologic agent of heterophile positive infectious mononucleosis. AB - The antibody activity against herpes-type virus (HTV) of heterophile-positive infectious mononucleosis sera and "normal" sera from humans was determined with immunoferritin. The antiviral activity of the mononucleosis sera was associated with the IgM antibodies, while the antiviral activity of the "normal" human sera was associated with the IgG antibodies. It was concluded from these findings that the appearance of antibodies to herpes-type virus in heterophile-positive sera represents a primary immunogenic exposure to this virus, or to a serologically related virus. This conclusion, in turn, suggests that herpes-type virus or a serologically related virus is the etiologic agent of heterophile-positive mononucleosis. PMID- 4327002 TI - Effect of rifampicin and two of its derivatives on cells infected with Moloney sarcoma virus. AB - It is shown that rifampicin, and especially the related antibiotic 2',6'-dimethyl N(4')-benzyl-N(4')- [desmethyl]rifampicin (DMB-rifampicin) can inhibit focus formation by Moloney sarcoma virus on BALB/3T3 tissue cultures. At 10 mug/ml DMB rifampicin totally inhibits focus formation while reducing virus replication by at least a factor of fifty and cell proliferation by only a factor of three. These observations, taken together with those of others, suggest a role for an RNA-dependent DNA polymerase and the gene for its synthesis both in normal cell processes and in the transformation process. PMID- 4327003 TI - Purification of IMP:pyrophosphate phosphoribosyltransferases, catalytically incompetent enzymes in Lesch-Nyhan disease. AB - IMP:pyrophosphate phosphoribosyltransferase (IPPase) (EC 2.4.2.8) has been purified over 7000-fold from human erythrocytes. The purified enzyme moved as a single band on disc electrophoresis. Antisera prepared in rabbits and rats against the purified enzyme precipitated and neutralized the enzyme, but had no effect on AMP-pyrophosphate phosphoribosyltransferase (EC 2.4.2.7) activity. Evidence was found for isozymes (enzyme variants) of IPPase in normal erythrocytes. Erythrocyte lysates of five patients with Lesch-Nyhan disease reacted with antisera against normal IPPase. Lysates from LN erythrocytes blocked the inactivation of normal enzyme by the antibody. LN erythrocytes had about the same concentration of enzyme protein as normal erythrocytes. The genetic defect in LN results in the production of essentially normal amounts of an immunologically identifiable but catalytically incompetent enzyme. Thus LN is apparently the result of a mutation in a structural gene and is not due to deletion of a structural gene or defect in a regulatory gene. PMID- 4327004 TI - Primer requirement and template specificity of the DNA polymerase of RNA tumor viruses. AB - Polyribonucleotides will act as efficient templates for the DNA polymerases found in the virions of avian myeloblastosis virus and mouse leukemia virus if a short complementary oligodeoxyribonucleotide primer is added. Synthesis of the complementary polydeoxyribonucleotide continues until an amount of polymer equal to the amount of initial template has been produced. The two viruses show slightly different specificities toward the four homoribopolymers. Polydeoxyribonucleotides are generally much poorer templates than the homologous polyribonucleotides, in most cases yielding no detectable synthesis. The DNA polymerase of RNA tumor viruses, therefore, have the same requirements for activity as do other DNA polymerases, except that they prefer polyribonucleotides over polydeoxyribonucleotides as templates. PMID- 4327005 TI - Transformation of mouse 3T3 cells by murine sarcoma virus: release of virus-like particles in the absence of replicating murine leukemia helper virus. AB - Small numbers of virus-like particles were observed by electron microscopy in each of two cloned lines of 3T3 cells transformed by murine sarcoma virus, even though these lines were free of detectable quantities of infectious leukemia and sarcoma virus. The morphology and occurrence of the particles were identical to those of the murine leukemia-sarcoma group. Moreover, the particles incorporated uridine and had a buoyant density of 1.16 g/ml in sucrose gradients. No evidence of sarcoma or leukemia virus infectivity was associated with the particles in cells of several susceptible species under various conditions, including both cosedimentation with leukemia virus and infection in the presence of inactivated Sendai virus. The particles may represent a form of murine sarcoma virus deficient in one or more of the viral components necessary for infectivity. PMID- 4327006 TI - Components of adenovirus-simian virus 40 hybrid viruses. AB - The DNA and protein components of the adenovirus 7-simian virus (SV)40 hybrid virus "E46(+)" have been investigated. The Ad.7-SV40 hybrid DNA genome could be distinguished from nonhybrid Ad. 7 genome on the basis of its molecular weight in an alkaline sucrose gradient. The hybrid genome could also be separated from nonhybrid adenovirus 2 DNA when purified transcapsidant adenovirus 2(+t7) (Ad.7 SV40 DNA within an Ad.2 capsid) was studied. The presence and amount of SV40 DNA in the hybrid virus genome was determined by DNA-RNA hybridization. The results presented suggest: (i) that about 10% of the particles in the E46(+) preparations contained SV40 DNA covalently linked to adenovirus DNA; (ii) that the hybrid virus genome has a molecular weight 10-12% lower than that of nonhybrid virus, consistent with a deletion of adenovirus DNA; and (iii) that the hybrid virus contained only 40-50% of a total SV40 genome. The protein components of the Ad.7 SV40 hybrid virus were examined by acrylamide gel electrophoresis in sodium dodecyl sulfate. No significant quantitative or qualitative differences between the proteins of hybrid and nonhybrid adenovirus were demonstrated. PMID- 4327007 TI - Microbial metabolism of the isoprenoid alkane pristane. AB - The "inert" hydrocarbon pristane (2,6,10,14-tetramethylpentadecane) can be utilized as the sole source of carbon and energy for growth of a coryneform soil isolate. Identification of the metabolites 4,8,12-trimethyltridecanoic acid and alpha-methylglutaric acid indicates that two pathways of fatty acid metabolism operate in this bacterial strain. The widespread use of pristane as a biological marker appears to be predicated on its structural similarity to phytol and its apparent stability, which may be only a reflection of the inability of microorganisms to carry out its anaerobic destruction. PMID- 4327008 TI - Ultrastructural comparison of a virus from a Rhesus-monkey mammary carcinoma with four oncogenic RNA viruses. AB - The ultrastructure and morphogenesis of Mason-Pfizer monkey virus, isolated from a mammary carcinoma in a Rhesus monkey, was compared with those of murine mammary tumor virus, murine leukemia virus, L1210 leukemia-associated virus, and avian myeloblastosis virus. The simian virus resembled murine mammary tumor virus and the L1210 virus in that it produced intracytoplasmic particles that were enveloped during budding. It resembled L1210 virus and murine leukemia virus in budding with smooth envelopes. It differed from all the others in being more fragile. These similarities, combined with biochemical characteristics reported elsewhere in this issue, suggest that the monkey virus is an oncogenic RNA virus. PMID- 4327010 TI - Establishment and propagation of Ibadan strains of Entamoeba histolytica in vitro. PMID- 4327009 TI - Further changes in differentiation state accompanying the conversion of Chinese hamster cells of fibroblastic form by dibutyryl adenosine cyclic 3':5' monophosphate and hormones. AB - The morphological conversion in vitro of Chinese hamster ovary cells to a fibroblast form by a relatively large amount of dibutyryl adenosine cyclic 3':5' monophosphate, or by a combination of small amounts of this compound and testosterone, is attended by appearance of the following additional properties: acquisition of strict contact inhibition of growth; reorientation of the random growth pattern into one in which cells grow parallel to their long dimension; disappearance of the randomly distributed, knob-like, pseudopodal structures around the cell periphery; induction of collagen synthesis; and decrease in the ability to be agglutinated and rounded up by plant agglutinins and specific cell antibodies. The changes in these characteristics are consistent with the conversion from a malignant to a normal fibroblastic state. This conversion is under genetic control, as demonstrated by the production of specific mutants with altered characteristics. The response to testosterone is specific since steroids like estradiol and hydrocortisone are inactive, and others have limited activity. Some prostaglandins are equal in activity to testosterone and 5alpha dihydrotestosterone. This system appears useful in study of the regulation of phenotypic expression in mammalian cells. PMID- 4327011 TI - Immunodiffusion tests for antibodies to herpes simplex (H.S.), varicella zoster (V.-Z.) and cytomegaloviruses (CMV). PMID- 4327012 TI - Viruses and disease. 3. An outbreak of adenovirus type 7A in a children's home. PMID- 4327013 TI - [Histochemical and ultrastructural study of a case of type 3 glycogenosis]. PMID- 4327014 TI - [Introduction to the study of muscular disorders in endocrinopathies]. PMID- 4327016 TI - [2 cases of allergic reaction after sialography]. PMID- 4327015 TI - Mitochondrial citric acid cycle and related enzymes: adaptive response to exercise. PMID- 4327017 TI - [Histological findings after intraarterial cytostatic perfusion of malignant tumors in the orofacial region]. PMID- 4327018 TI - [Immunological study of nasopharyngeal carcinoma]. PMID- 4327019 TI - Accurate and rapid measurement of plasma renin activity by radioimmunoassay. Results in normal and hypertensive people. PMID- 4327020 TI - Placental transfer of vitamin D3 and 25-hydroxycholecalciferol in the rat. PMID- 4327021 TI - Synthesis of (5-valine,7-N-methylalanine)-angiotensin II, a hypertensive peptide. PMID- 4327022 TI - The adsorption of fibrinogen. An electron microscope study. PMID- 4327023 TI - Adsorption inhibition as a mechanism for the antithrombogenic activity of some drugs. I. Competetive adsorption of fibrinogen and heparin on mica. PMID- 4327024 TI - [The lung after lymphography]. PMID- 4327025 TI - Wilms' tumor. PMID- 4327026 TI - Cutaneous inflammations of the male genitalia. PMID- 4327028 TI - Mixed RNAs in transformed cells. PMID- 4327027 TI - Cramps. PMID- 4327029 TI - Syncope: a review of pathophysiological mechanisms. PMID- 4327030 TI - [Neuropsychiatric complications caused by cortisone and ACTH. (Clinico-social considerations)]. PMID- 4327031 TI - Foetal enzyme patterns in cancer tissues. PMID- 4327032 TI - [3H]adenosine triphosphate: release during stimulation of enteric nerves. AB - The isolated taenia coli of the guinea pig takes up tritiated adenosine, adenosine monophosphate, adenosine diphosphate, and adenosine triphosphate, in preference to tritiated inosine and adenine. After uptake, [(3)H]adenosine is converted and retained primarily as [(3)H]adenosine triphosphate. Tritium is released from taenia coli treated with [(3)H]adenosine upon activation of the nonadrenergic inhibitory nerves. These results are consistent with the previous evidence that adenosine triphosphate may be the transmitter from the nerves. PMID- 4327033 TI - [The innervation of the autonomically pulsating portal vein of the rat. Fluorescence and electronmicroscopic study]. PMID- 4327034 TI - [Cerebral fat embolism, complication of lipiodol lymphographic examination]. PMID- 4327035 TI - Uptake of 5-hydroxytryptamine by mast cell granules in vitro. PMID- 4327036 TI - Action potential generation in denervated rat skeletal muscle. II. The action of tetrodotoxin. PMID- 4327037 TI - Inotropic and metabolic effects of dibutyryl cyclic adenosine 3', 5' monophosphate in the perfused rat heart. PMID- 4327038 TI - Reproducibility of rating bone development (Tanner-Whitehouse system). PMID- 4327039 TI - Feline lipidosis. Light and electron microscopic studies. PMID- 4327040 TI - Effect of the proline analogue azetidine-2-carboxylic acid on collagen synthesis in vivo. II. Morphological and physical properties of collagen containing the analogue. PMID- 4327041 TI - Beta-structure in glyceraldehyde-3-phosphate dehydrogenase. PMID- 4327042 TI - Chemical nature of the inactivation of Bacillus cereus penicillinase by iodine. PMID- 4327043 TI - Study on the properties and structure of the modified base Y+ of yeast tRNA Phe . PMID- 4327044 TI - A circular dichroism study on the conformation of DNA in rat liver chromatin. PMID- 4327045 TI - Structural and compositional changes in the red cell membrane during Clostridium welchii infection. PMID- 4327046 TI - Cyclic hormone therapy in climacteric and menopausal women in Iran. Report of 600 cases. PMID- 4327047 TI - [Further observations on Paget's cell]. PMID- 4327048 TI - Control of unitary activities in cerebellothalamic pathway during wakefulness and synchronized sleep. PMID- 4327049 TI - The cerebroretinal degenerations. PMID- 4327050 TI - Pituitary function in the deprivation syndrome. PMID- 4327051 TI - Islet cell adenomatosis and adenoma in an infant. PMID- 4327053 TI - Paget's disease and apocrine gland carcinoma of the vulva. PMID- 4327052 TI - Plasma 17-ketosteroids and 17-beta hydroxysteroids in girls with premature development of sexual hair. PMID- 4327054 TI - Plastic management of extensive vulvar defects. PMID- 4327055 TI - [Mixed tumors of the palate. Report of a case and differential diagnosis of the swellings of the palate]. PMID- 4327057 TI - [Difficulties in the differential diagnosis of a pancreatic islet cell tumor]. PMID- 4327056 TI - [Clinical aspects and prognosis in Wilms' tumor]. PMID- 4327058 TI - The multiple aetiology of viral hepatitis. PMID- 4327059 TI - Voluntay after-duty follow-up care of malnourished children in the Port Elizabeth area. PMID- 4327060 TI - The effect of simultaneous and alternate feeding of furylfuramide and 4 dimethylaminoazobenzene on rats. PMID- 4327061 TI - [Synthesis of ribonucleic acid and protein of poliomyelitis virus at low temperature]. PMID- 4327062 TI - [Significance of preliminary treatment of lymphoid tissue with antigen in the process of hyperreproduction of anti-viral antibody]. PMID- 4327063 TI - [Preventive effect of human leukocytic interferon in preschool children]. PMID- 4327064 TI - [Inhibition by pironine of RNA virus multiplication]. PMID- 4327065 TI - [Leukovirus RNA-dependent DNA polymerase]. PMID- 4327066 TI - [Leprosy research]. PMID- 4327068 TI - [Amebiasis]. PMID- 4327069 TI - [Therapy of eye diseases with Corti Biciron eye ointment]. PMID- 4327070 TI - Effect of magnesium trisilicate o the antibacterial activity of benzalkonium chloride. PMID- 4327067 TI - Human lymphoblastoid cell lines and Epstein-Barr virus: a review of their interrelationships and their relevance to the etiology of leukoproliferative states in man. PMID- 4327071 TI - [Metabolism of the human extraocular muscles]. PMID- 4327072 TI - Alterations in hepatic enzyme activities due to cold exposure rather than changes in diet. PMID- 4327073 TI - Rate-limiting factor in rat kidney slice ammoniagenesis. PMID- 4327074 TI - Renal mitochondrial enzymes in potassium depletion. PMID- 4327075 TI - Effects of carp kidney extract and angiotensin II on adrenal steroid secretion. PMID- 4327076 TI - Perianal Paget's disease. PMID- 4327077 TI - Inhibition of oxidative phosphorylation by hydroxylamine in sonicated particles from beef-heart mitochondria. PMID- 4327078 TI - A micro-method for the study of oxidative phosphorylation. PMID- 4327079 TI - The unsaturated fatty acid content of mitochondria in relation to oxidation of exogenous reduced nicotinamide adenine dinucleotide. PMID- 4327080 TI - One-electron reactions in biochemical systems as studied by pulse radiolysis. IV. Oxidation of dihydronicotinamide-adenine dinucleotide. PMID- 4327081 TI - The preparation and properties of a solubilized respiratory complex from Escherichia coli. PMID- 4327082 TI - Calcium absorption and the vitamin D 3-dependent calcium-binding protein. I. Inhibition by dietary strontium. PMID- 4327083 TI - Calcium absorption and the vitamin D 3-dependent calcium-binding protein. II. Recovery from dietary strontium inhibition. PMID- 4327084 TI - Isolation of a non-focus-forming agent from strain MC29 avian leukosis virus. PMID- 4327085 TI - Effect of crystalline ricin on the biosynthesis of protein, RNA, and DNA in experimental tumor cells. PMID- 4327087 TI - Promotion of aflatoxin-induced hepatoma growth in trout by methyl malvalate and sterculate. PMID- 4327086 TI - L-asparaginase in the treatment of neoplastic diseases in children. PMID- 4327088 TI - Occurrence of antibodies to the T antigen of chicken embryo lethal orphan virus. PMID- 4327089 TI - Demonstration and identification of cytotoxic antibodies and antibodies blocking the cell-mediated antitumor immunity against adenovirus type 12-induced tumors. PMID- 4327090 TI - [Histotopochemical determination of various dehydrogenases and oxidases in the human dental pulp (study of pulp nerves)]. PMID- 4327091 TI - Glutamine and glutamine synthetase in fetal, adult and neoplastic rat tissues. PMID- 4327093 TI - Light-induced structural transitions of chloroplasts studied by the spin-probe method. PMID- 4327092 TI - Diacetyl (Acetoin) reductase from Aerobacter aerogenes. Evidence for multiple forms of the enzyme. PMID- 4327094 TI - [Participation of the amygdaloid complex in the transference of stimuli to the cerebral cortex]. PMID- 4327095 TI - [Convergence of afferent influences on neurons of the pigeon vestibular nuclei]. PMID- 4327096 TI - [Tonic impulsation of the vagus nerve during sleep and wakefulness]. PMID- 4327097 TI - [Manifestation of the conditioning effect (development of temporal connections) on the neurons of a cortex isolated from subcortical effects]. PMID- 4327098 TI - [Integration processes during interoceptive signals]. PMID- 4327099 TI - [Electrical transmission between symmetrical neurons in leech ganglia]. PMID- 4327100 TI - [Restitution processes following muscular activity at different temperatures]. PMID- 4327101 TI - Sex ratio by age in childhood malignancies. PMID- 4327103 TI - [Chemodectoma of the vagus nerve]. PMID- 4327102 TI - Granular cell myoblastoma (granular cell schwannoma) of the right upper bronchus coexisting with a bronchogenic carcinoma. Report of the first case in the literature. PMID- 4327104 TI - Preparation and use of a new artificial system for factor XI assay. PMID- 4327105 TI - Cyclic adenosine monophosphate as a mediator of hormone action. PMID- 4327106 TI - Impaired cell-mediated immunity and antibody titers. PMID- 4327107 TI - [Ovarian struma]. PMID- 4327108 TI - Cytomegalovirus mononucleosis in a first trimester pregnant female with transmission to the fetus. PMID- 4327109 TI - Islet cell adenoma in the newborn: report of two patients. PMID- 4327110 TI - Colon carcinoma in childhood. PMID- 4327111 TI - Floxuridine treatment of congenital cytomegalic inclusion disease. PMID- 4327113 TI - Nucleic acid and proteins isolated from a strain of murine sarcoma virus (MSV-O). PMID- 4327112 TI - Adrenals in ectopis ACTH syndrome. PMID- 4327115 TI - Recovery of tissue bound polymyxin B and colistimethate. PMID- 4327114 TI - Cyclic-AMP in the perfused failing guinea pig heart. PMID- 4327116 TI - Uptake of exogenous tRNA by Novikoff hepatoma ascites cells. PMID- 4327118 TI - Effect of diet on N,N-dimethyl-p-(m-tolylazo)aniline carcinogenesis in rats. PMID- 4327117 TI - Effect of tolbutamide and exogenous insulin on the metabolic responses of rats. PMID- 4327119 TI - Hansen's disease in a peripheral nerve. PMID- 4327120 TI - Viral genetic systems. PMID- 4327121 TI - [Clinical experiences with vinblastine sulfate]. PMID- 4327122 TI - [Electron microscopic studies on the experimental deciduoma in the rat]. PMID- 4327123 TI - [Experimental studies on lipolysis in adipose tissue from man and guinea pig]. PMID- 4327124 TI - [Possibilities of intermittent therapy of progressive chronic polyarthritis]. PMID- 4327125 TI - [Attempts to adapt Entamoeba histolytica to various protozoan species in Diamond's TTY medium]. PMID- 4327126 TI - [Demonstration of the Mengo virus antigen in the mouse brain by help of the immunofluorescence technique]. PMID- 4327127 TI - The significance of giant vacuolation of endoneurial fibroblasts. PMID- 4327128 TI - Immunofluorescent studies on circulating lymphocytes in oral mucosal diseases. PMID- 4327129 TI - Inhibition of transplantable tumour cells by tetanus spores. PMID- 4327131 TI - A review of plasma renin measurements and their clinical significance. PMID- 4327132 TI - Effect of blood on the response of the rabbit ear artery to noradrenaline and angiotensin II. AB - Blood or plasma added to the perfusing Krebs solution potentiated the vasoconstrictor effects of noradrenaline and angiotensin II on the isolated ear artery of the rabbit. The relatively greater increase in the vasoconstrictor effect of angiotensin II in the presence of blood or plasma may account for part of its potent pressor activity in vivo. PMID- 4327130 TI - Lactate metabolism in rat lung tissue. PMID- 4327133 TI - [Presence in the normal liver of substances inhibiting the early growth of cancer cell cultures]. PMID- 4327134 TI - [Complement fixation with a soluble antigen: important differences of activity between the serums of Burkitt lymphoma, of rhinopharynx cancers and infectious mononucleosis]. PMID- 4327135 TI - [Increase of the duration of paradoxical sleep due to learning in the rat]. PMID- 4327136 TI - [Action of (+)-catechin on experimental liver steatosis in the white rat]. PMID- 4327137 TI - [Note on the ultrastructural localization of adenosinemonophosphatase in the neonatal liver (mouse)]. PMID- 4327138 TI - [Sex influences on the response of the hypothalamo-hypophysio-adrenal axis to emotional and systemic stress in the rat]. PMID- 4327140 TI - Plasma cortisol concentration and the rate of intestinal water absorption in the eel, Anguilla japonica. PMID- 4327139 TI - Regulation of pancreatic beta-cell glycogen through cyclic-3,5-AMP. PMID- 4327141 TI - [Survival of entero- and adenoviruses in water]. PMID- 4327142 TI - [Sanitary-index significance of coliform bacteria during different conditions of decontamination of water for enteroviruses]. PMID- 4327143 TI - Early effects of phytohemagglutinin (PHA) on lymphocyte cyclic AMP levels. PMID- 4327144 TI - A potential method for enumerating antigen-sensitive cells in delayed hypersensitivity. PMID- 4327145 TI - Effects of hypothalamic deafferentation on adrenocortical responses to cold stress. PMID- 4327147 TI - Surgical treatment of brain stem gliomas. PMID- 4327146 TI - Effect of the nonionogenic detergent, Nonidet P-40, on enveloped herpes simplex virions. PMID- 4327148 TI - Human growth hormone in cultures of human pituitary tumors. PMID- 4327149 TI - Brain tumor of mixed mesenchymal and neuroepithelial origin. Case report. PMID- 4327151 TI - [EPR-spectroscopy]. PMID- 4327150 TI - Radiosensitivity--what is it? PMID- 4327152 TI - The rigid form of Huntington's chorea. PMID- 4327153 TI - A reevaluation of edrophonium chloride (Tensilon) tonography in the diagnosis of myasthenia gravis. With observations on some other defects of neuromuscular transmission. PMID- 4327154 TI - Trigeminal neuropathy in connective tissue disease. PMID- 4327155 TI - Adenoid cystic carcinoma of the cervix. An analysis of 12 cases. PMID- 4327156 TI - Peritoneal fluid cytology in irradiation-induced ovarian tumors of mice. PMID- 4327157 TI - Manifestations of genetic diseases in the human pulp. PMID- 4327158 TI - [Giant cell tumors of the tendon sheaths of the hand]. PMID- 4327160 TI - [Electron microscopic study of intracellular contacts in transplantable hepatomas of mice]. PMID- 4327161 TI - [Increase in non-specific cell resistance during stimulation of protein synthesis with 8-mercaptoadenine]. PMID- 4327163 TI - [Idiopathic hemochromatosis with involvement of the nervous system]. PMID- 4327162 TI - [Blood cortisol in neoplasm cases]. PMID- 4327164 TI - [Endocrine polyadenomatosis combined with a tentorial meningioma]. PMID- 4327165 TI - [Immunochemical study of the enzymes of a toxic complex of Cl. perfringens]. PMID- 4327166 TI - [Chemotherapy of kidney tumors in children]. PMID- 4327167 TI - [Recurrent nerve compression]. PMID- 4327168 TI - Fetal hamartoma of the kidney: report of two new cases of this neonatal tumor as differentiated from Wilms' tumor. PMID- 4327169 TI - The ultrastructure and cytochemistry of the shell membrane-secreting region of the Japanese quail oviduct. PMID- 4327170 TI - The opisthonephric kidney of the sea lamprey of the Great Lakes, Petromyzon marinus L. V. The archinephric duct. PMID- 4327171 TI - Argentaffin and other "endocrine" cells of the small intestine in the adult mouse. I. Ultrastructure and classification. PMID- 4327172 TI - Fine structure of the taste bud in the mud puppy, Necturus maculosus. PMID- 4327174 TI - [Wilms' tumor can be cured]. PMID- 4327173 TI - Lactic dehydrogenase isoenzyme alterations in malignant disease of the liver. PMID- 4327176 TI - Optics and visual physiology. PMID- 4327175 TI - Primary mediastinal neoplasms in infants and children. PMID- 4327177 TI - Cytomegalic inclusion retinitis in an adult. PMID- 4327178 TI - On the effect of the hypolipidaemic phenyl ether CH 13 437 on the liver metabolism of the rat. PMID- 4327179 TI - [Aldolase isoenzymes in brain tumor]. PMID- 4327180 TI - [Somatosensory evoked potentials in neurosurgical diseases]. PMID- 4327181 TI - [Plastic surgery on the trachea and bronchi]. PMID- 4327182 TI - In vitro resistance of Clostridium perfringens type A to gentamicin sulfate, and reduced activity of the antibiotic under anaerobic atmospheric conditions. PMID- 4327183 TI - Determination of electrical sources in the mammalian heart from intracellular action potentials. PMID- 4327184 TI - Hemodynamic effects of angiotensin in normal and environmentally stressed monkeys. PMID- 4327185 TI - Quartz as a heat-resistant dosimeter. PMID- 4327186 TI - The mechanism of action of uridine diphosphoglucose dehydrogenase. Uridine diphosphohexodialdoses as intermediates. PMID- 4327187 TI - Methylation of deoxyribonucleic acid during hormonal stimulation of mammary cells in vitro. PMID- 4327188 TI - Stimulation of adenosine 3',5'-monophosphate hydrolysis by guanosine 3',5' monophosphate. PMID- 4327189 TI - The reaction inactivation of citrate lyase from Aerobacter aerogenes. PMID- 4327190 TI - Endonuclease I of Proteus mirabilis. Properties of the noncomplexed and transfer ribonucleic acid-complexed forms of the enzyme. PMID- 4327191 TI - The binding of detergents to proteins. I. The maximum amount of dodecyl sulfate bound to proteins and the resistance to binding of several proteins. PMID- 4327192 TI - Glucosylation of lipopolysaccharide in Salmonella: biosynthesis nof O antigen factor n12 2 . II. Structure of the lipid intermediate. PMID- 4327193 TI - The purification of bovine thyroid plasma membranes and the properties of membrane-bound adenyl cyclase. PMID- 4327194 TI - Properties of a particulate chitin synthetase from Mucor rouxii. PMID- 4327195 TI - Temperature-induced phase changes in mitochondrial membranes detected by spin labeling. PMID- 4327197 TI - Effect of phospholipases and lipase on submitochondrial particles. PMID- 4327198 TI - [Viral infection in Indonesia--immuno-epidemiological studies]. PMID- 4327196 TI - On the mode of action of lipid-lowering agents. VI. Inhibition of lipogenesis in rat mammary gland cell culture. PMID- 4327199 TI - [Symposium on problems involved in vaccination]. PMID- 4327200 TI - [Pharmacological model of paradoxical sleep induced by a cholinergic substance: oxotremorine]. PMID- 4327201 TI - [Intervention of cyclic A.M.P. in sedation phenomena]. PMID- 4327202 TI - [Automatic analysis of wake-sleep states in rats]. PMID- 4327203 TI - [Inhibition of GABA transaminase and wake-sleep behaior in rats]. PMID- 4327204 TI - [Scientific-technical progress and medicine]. PMID- 4327205 TI - [Changes in the antitoxic function of the liver in patients with acute dysentery during different methods of treatment]. PMID- 4327206 TI - Microangiopathic hemolytic anemia. Review and report of two cases. PMID- 4327208 TI - The influence of low LSD dose administration during sleep in rats. PMID- 4327207 TI - Metabolism of tritiated angiotensin II in anaesthetized rats. PMID- 4327209 TI - [Hepatography and splenography with ultrafluid lipiodol]. PMID- 4327210 TI - [Hepatoma. Review of cases]. PMID- 4327211 TI - [Contribution of transparietal hepatic cholangiography in 2 cases of Vater's ampulla adenocarcinoma]. PMID- 4327212 TI - [Hypotonic duodenography and combined transcutaneous cholangiography in 1 stage. Its diagnostic value]. PMID- 4327213 TI - [Hormonal regulation of postnatal growth]. PMID- 4327214 TI - [Influence of ACTH on various aspects of carbohydrate metabolism. I. Evaluation of blood sugar and ascorbic acid in hypophysectomized and normal rats]. PMID- 4327215 TI - Sex ratio of gastric cancer related to site of the tumour. PMID- 4327216 TI - Nephroblastoma in childhood. PMID- 4327217 TI - [Rheumatoid purpura (Schonlein-Henoch syndrome) in the adult. Apropos of 22 cases]. PMID- 4327218 TI - [Circulating anticoagulants]. PMID- 4327219 TI - [Tuberculosis of deep hematopoietic organs and its hematologic manifestations. Apropos of 6 personal cases]. PMID- 4327220 TI - [Colic polyps. Importance of detection and of identification by colonoscopy]. PMID- 4327221 TI - [Evolutive hyperparathyroidism and chronic uremia in substitute dialysis. Apropos of 2 cases]. PMID- 4327222 TI - [Hepatic manifestations of hyperthyroidism. 19 bio-histologic observations]. PMID- 4327223 TI - [Abnormalities of carotid piezogram premonitory of arterial hypertension in the course of nephropathies]. PMID- 4327224 TI - [Gangrene of the abdominal wall due to Clostridium bifermentans]. PMID- 4327225 TI - [Male sterility]. PMID- 4327226 TI - [Hypercalcemic syndrome in the adult. Diagnostic and therapeutic problems]. PMID- 4327227 TI - [Retroperitoneal fibroblastic sarcoma: value of vascular and lymphographic explorations]. PMID- 4327228 TI - [Electron microscopic study of secretion by the exocytosis route]. PMID- 4327229 TI - [Antibiotic, triphenylmethane dyes and boric acid in increased occurrence of Pseudomonas aeruginosa]. PMID- 4327230 TI - [New viewpoints on the treatment of gas gangrene (Clostridium perfringens)]. PMID- 4327231 TI - [Severe forms of adenovirosis in children: various recent cases]. PMID- 4327232 TI - Studies on adenyl cyclase in Necturus gastric mucosa. PMID- 4327233 TI - Observations on the structure of pullulan. PMID- 4327234 TI - The regulatory function of potato pyruvate dehydrogenase. PMID- 4327235 TI - Further studies on the properties of the rabbit reticulocyte adenosine 3',5' cyclic monophosphate-dependent protein kinase I. PMID- 4327236 TI - Control of glycolysis and respiration in substrate-depleted Ehrlich ascites tumor cells. PMID- 4327237 TI - EPR study of Cu(II) complexes of tridentate amino acids. PMID- 4327238 TI - Molecular state of cy tochrome c oxidase on polyacrylamide gel electrophoresis. PMID- 4327240 TI - Pyridine nucleotide binding sites of pig heart lipoyl dehydrogenase: fluorescence titrations. PMID- 4327239 TI - Isosteric relationship of biologically active N 6 -( -phenylalkyl) adenines and N 6 -( -1',4'-xyxlohwzadien-1'-y-alkyl)adenines. PMID- 4327241 TI - The effect of 2,2-diphenyl-1-picrylhydrazyl and p-cresol on the oxidative degradation of indole-3-acetate. PMID- 4327242 TI - Phosphoenolpyruvate carboxylase isoenzymes: separation and properties of three forms from cotton leaf tissue. PMID- 4327243 TI - Partial purification of the outer membrane fraction from sonicated heavy beef heart mitochondria. PMID- 4327244 TI - [Radiological study of liver neoplasms in children (apropos of 26 cases)]. PMID- 4327246 TI - Light induced free radicals in hematoporphyrin-serum protein systems. PMID- 4327245 TI - [Study in man of recirculation and tissue uptake of 5-FU 6 H3]. PMID- 4327247 TI - [Polyphosphatases of baker's yeast]. PMID- 4327248 TI - Electron microscopy of the Tana poxvirus. PMID- 4327249 TI - [Effects of 8 various aldehydes and of the pH value on the localization of glucose-6-phosphatase in cultured cells]. PMID- 4327250 TI - [Inhibition of autolysis in renal tissue by the kallikrein inactivator Trasylol. Histological and histochemical studies]. PMID- 4327251 TI - [Bacteriology of whooping cough. II. Determination of the major agglutinant factors in Bordetella pertussis samples isolated in Rio de Janeiro]. PMID- 4327252 TI - Cytomegalovirus complement-fixation antibody responses in Eskimo families. PMID- 4327253 TI - Parainfluenza virus immunofluorescence. In vitro and clinical application of the direct method. PMID- 4327254 TI - Clear cell hidradenoma with metastasis. Case report with a review of the literature. PMID- 4327255 TI - [Masculinizing tumors of the adrenal cortex in children before puberty]. PMID- 4327256 TI - [Subacute and chronic pancreatitis, massive ascites and subcutaneous fatty necrosis: 2 cases; review of the literature]. PMID- 4327257 TI - [Sulpiride for peptic ulcer]. PMID- 4327258 TI - [A recent case of associated fibrous dysplasia of bone and soft tissue myxoma]. PMID- 4327259 TI - [Treatment of aortic coarctation in young infants and children]. PMID- 4327260 TI - [Treatment of multiple myeloma with melphalan: 35 personal cases]. PMID- 4327261 TI - [Bioclinical study of a case of hyperparathyroidism secondary to phosphate diabetes]. PMID- 4327262 TI - [Genetic and immunologic factors in human leukemogenesis]. PMID- 4327263 TI - [Glycoregulation in vagotomy patients having undergone drainage operation]. PMID- 4327264 TI - [Pallidal syndrome with symmetrical calcification of the corpus striatum]. PMID- 4327265 TI - [Extrinsic compression of the thoracic esophagus of lymph node origin wrongly considered a begnin tumor of the esophagus]. PMID- 4327267 TI - [3 cases of small cancers of the esophagus]. PMID- 4327266 TI - [Bezoars of the esophagus]. PMID- 4327268 TI - [Annular and submucous cancer of the lower esophagus simulating a megaesophagus]. PMID- 4327269 TI - [Double pylorus: a congenital malformation]. PMID- 4327271 TI - [Gastric adenocarcinoma]. PMID- 4327270 TI - [Calcified and degenerated gastric intramural myoid tumor]. PMID- 4327272 TI - [Gastric localization of Hodgkin's disease]. PMID- 4327273 TI - [Ileoileal invagination into a gastrectomy stump]. PMID- 4327274 TI - [Hemorrhagic acute mucous ulcer of the 2d duodenal segment]. PMID- 4327275 TI - [Recurrence of duodenal ulcer after technically imperfect vagotomy and pyloroplasty]. PMID- 4327276 TI - [Primary cancer of the D2-D3 angle in a 30-year-old woman]. PMID- 4327277 TI - [Degenerated villous tumor of the jejunum]. PMID- 4327278 TI - [Ileocolic Crohn's disease]. PMID- 4327279 TI - [Well localized stenosis of the right colic angle]. PMID- 4327280 TI - [Benign double tumor of the colon (villous tumor and polyadenoma) and appendicular mucocele]. PMID- 4327281 TI - [A further case of appendicitis of tumoral form]. PMID- 4327282 TI - [Apropos of a case of intrahepatic biliobiliary communication between an ectopic right hepatic duct and the ordinary right hepatic duct]. PMID- 4327283 TI - [Stenosis of the choledochus after gastrectomy]. PMID- 4327284 TI - [Cystadenocarcinoma of the tail of the pancreas]. PMID- 4327285 TI - [Curved ligament of the radiologic celiac trunk without hemodynamic consequences associated with a false arteriographic image of paraduodenal internal hernia]. PMID- 4327286 TI - [Action of pig gastrin and of gastrinic pentapeptide on pancreatic and biliary secretions in the anesthetised rat]. PMID- 4327287 TI - [Articular manifestations of aphthosis (Behcet's syndrome)]. PMID- 4327288 TI - [Electrocardiographic abnormalities in the course of induced abortions]. PMID- 4327289 TI - [Cerebal tumors and pregnancies]. PMID- 4327290 TI - [Shock. Physiopathologic, clinical and therapeutic study]. PMID- 4327291 TI - In vitro platelet reaction with isolated glomerular basement membrane. Ultrastructural comparison with platelet-collagen reaction. PMID- 4327292 TI - [Juvenile melanoma]. PMID- 4327293 TI - [Enterogenous non-traumatic gas phlegmon infection by Clostridium septicum]. PMID- 4327294 TI - Membranous stacks in human glioblastoma multiforme. PMID- 4327295 TI - Perinatal risk associated with maternal genital herpes simplex virus infection. PMID- 4327296 TI - Diagnosis and treatment of premalignant lesions of the vulva: a review. PMID- 4327297 TI - [Electron microscopic studies on juvenile nasopharyngeal fibroma]. PMID- 4327298 TI - The human fetal synovium. Histology, fine structure and changes in organ culture. PMID- 4327299 TI - Energy linked NAD reduction in phophorylating submitochondrial particles from heavy layer beef heart mitochondria. A lag phenomenon and its localization. PMID- 4327300 TI - The insulin-like activity of cyclic nucleotides and their inhibition by caffeine on the isolated fat cells. PMID- 4327301 TI - Isolation of 2.4-dichlorophenol from a soil fungus and its biological significance. PMID- 4327302 TI - Enzymatic conversion of 14-alpha-methyl-cholest-7-en-3 beta, 15 zeta-diol to cholesterol. PMID- 4327303 TI - A simple non-enzymatic method to regenerate oxyhemoglobin from methemoglobin. PMID- 4327304 TI - [Stress and the adaptation syndrome from the surgical viewpoint]. PMID- 4327305 TI - [Identification and determination of antibiotics by reverse-phase thin layer chromatography]. PMID- 4327306 TI - Colorado breath alcohol program. PMID- 4327307 TI - The use of HEPES buffer in micro-tissue culture plates for routine enterovirus diagnosis. PMID- 4327308 TI - Effects of temperature on cobalt glass dosimeters. PMID- 4327310 TI - [Angiography of glomus tumor]. PMID- 4327309 TI - In vitro sensitivity of mycoplasmas isolated from various animals and sewage to antibiotics and nitrofurans. PMID- 4327311 TI - [Radioclinical comparison of tomographic analysis of the petrous bone]. PMID- 4327312 TI - A new approach for carrier detection in Duchenne muscular dystrophy. Protein synthesis of muscle polyribosomes in vitro. PMID- 4327313 TI - Viral infections in multiple sclerosis patients on low-dose immunosuppression. A prospective study. PMID- 4327314 TI - [Histochemical examination of kidneys and liver in experimental imipramine poisoning]. PMID- 4327315 TI - [Considerations on the circadian variations of endocrine functions. Physiopathologic aspects]. PMID- 4327317 TI - Automated sequential degradation of ribonucleic acids. PMID- 4327316 TI - High-resolution chromatographic system for measuring organic acids in biological samples. PMID- 4327318 TI - Effects of irradiation or traumatic injuries on propionate metabolism in rats. PMID- 4327319 TI - [Treatment of alcoholism]. PMID- 4327320 TI - [Membraneous-proliferating glomerulonephritis associated with the nephrotic syndrome]. PMID- 4327321 TI - [Determination of active principles of capsicum]. PMID- 4327322 TI - Redox components associated with chromatophores from Rhodospirillum rubrum. PMID- 4327323 TI - Regulation of microsomal enzymes by phospholipids. II. Acitvation of hepatic uridine diphosphate-glucuronyltransferase. PMID- 4327324 TI - In vitro transcription of the gal operon requires cyclic adenosine monophosphate and cyclic adenosine monophosphate receptor protein. PMID- 4327326 TI - Magnetic susceptibility measurements of cytochrome c peroxidase and its complexes. PMID- 4327325 TI - Studies on the meningococcal polysaccharides. II. Composition and chemical properties of the group B and group C polysaccharide. PMID- 4327327 TI - Methylation of mammalian deoxyribonucleic acid. II. The distribution of 5 methylcytosine in pyrimidine deoxyribonucleotide clusters in Novikoff hepatoma cell deoxyribonucleic acid. PMID- 4327328 TI - The nature of pH discriminatnt differences in the behavior of various phosphoanhydrides, mixed phosphate anhydrides, and phosphate esters as substrates and inhibitors with microsomal glucose 6-phosphatase. PMID- 4327329 TI - The binding of desialylated glycoproteins by plasma membranes of rat liver. PMID- 4327330 TI - The deoxyribonuclease induced after infection of Escherichia coli by bacteriophage T5. I. Characterization of the enzyme as a 5'-exonuclease. PMID- 4327331 TI - Radial palsy following muscular effort. A nerve compression syndrome possibly related to a fibrous arch of the lateral head of the triceps. PMID- 4327332 TI - Specific binding protein for active metabolites of vitamin D3. PMID- 4327333 TI - Vitamin D3 action of RNA synthesis in rat intestinal mucosa. PMID- 4327334 TI - Vitamin D3 binding protein in rat intestinal mucosa. PMID- 4327335 TI - [Isolation rate of Pseudomonas aeruginosa from clinical materials and its susceptibility to antibiotics]. PMID- 4327336 TI - [Anti-bacterial activity of capreomycin, kanamycin, or viomycin against drug resistant tubercle bacilli isolated from patients]. PMID- 4327337 TI - [The epidemiology and morphogenesis of breast cancer in the Bukovina endemic goiter focus]. PMID- 4327339 TI - Corticotropin therapy in myasthenia gravis: indications and limitations. PMID- 4327338 TI - Experimental ischemia and polyphosphoinositide metabolism. PMID- 4327340 TI - The relationship of the latencies of the monosynaptic reflex and the direct motor response: an electrophysiological aid in differential diagnosis. PMID- 4327341 TI - Neoplasms of the brain and cranial meninges: a study of incidence, epidemiological trends, and survival. PMID- 4327342 TI - Polymyositis: fine structure of capillaries and subcellular organelles. PMID- 4327343 TI - The response to muscle percussion: physiology and clinical significance. PMID- 4327344 TI - An improved method of preparing Schmidt-Ruppin Rous sarcoma virus for brain tumor induction in mammals. PMID- 4327345 TI - Structure and composition of nemaline rods: evidence that they represent replicating Z disk. PMID- 4327346 TI - [Inhibition by dipyridamole of the contractile response induced by angiotensin in the isolated rat uterus]. PMID- 4327347 TI - [Physiopathology and treatment of flashing pains]. PMID- 4327348 TI - [Prednisolone sensitivity in patients with tumors of the diencephalo-hypophyseal region]. PMID- 4327349 TI - [The effect of brain tumor removal on several biochemical and hematologic indices]. PMID- 4327350 TI - [Electron microscopy studies of rubeosis iridis]. PMID- 4327351 TI - Diseases of the optic nerve, tracts and visual cortex: an annual review of the ophthalmological literature. PMID- 4327353 TI - A comparative study of the cardiovascular reactivity in various hypertensive and in normotensive rats. PMID- 4327352 TI - [Induction and prevention of developmental abnormalities in rabbits by administration of 6-aminonicotinic acid and nicotinic acid amide]. PMID- 4327354 TI - [Relation of the electron paramagnetic resonance signal during photooxidation of chlorophyll by quinone to acidity of the medium]. PMID- 4327355 TI - [Change in the EPR spectra of mouse liver during poisoning by boric acid and carbon tetrachloride]. PMID- 4327356 TI - [Some properties of a group of neurons working in parallel. I. Neuron pool without connections]. PMID- 4327357 TI - [Free-radical mechanism of ultraweak chemiluminescence accompanying the peroxidation of unsaturated fatty acids]. PMID- 4327358 TI - [Study of spin labels in animal tissues]. PMID- 4327359 TI - [Smoothing of the statistical relation between impulse activity and ultraslow oscillations of potential proceeding in neuronal extracellular medium]. PMID- 4327360 TI - A neuronal model for the discharge patterns produced by cyclic inputs. PMID- 4327361 TI - Organismic supercategories. II. On multistable systems. PMID- 4327363 TI - A multichannel hybrid system for rapid eye movement detection (REM detection). PMID- 4327362 TI - Cold hypersenstivity in Raynaud's phenomenon. PMID- 4327364 TI - Oat cell carcinoma with hypercortisolemia presenting to a psychiatric hospital as a suicide attempt. PMID- 4327365 TI - [Problems in diagnosis and treatment of synovial sarcoma]. PMID- 4327366 TI - [Mechanical neuritis of the rami dorsales and hernia of the adipose tissue as etiologic factor in acute and chronic backache]. PMID- 4327367 TI - [A case of multiple myeloma showing on electrophoresis a double peak of IgG paraprotein with identical antigenic structure ( 2 K2 type)]. PMID- 4327368 TI - [Fahr's disease]. PMID- 4327369 TI - [Value of biometric investigations in pneumology]. PMID- 4327370 TI - [Treatment of systemic osteoporosis]. PMID- 4327371 TI - [Diagnosis and treatment of chronic pancreatitis]. PMID- 4327372 TI - [Retrograde inhibition in the olfactory bulb in frogs]. PMID- 4327373 TI - Electron-microscope studies on peripheral nerves in polyneuropathies and some diseases of the central nervous system. PMID- 4327374 TI - Submicroscopic localization of thiamine pyrophosphatase in spinal cord motoneurons in mice after compulsory work. PMID- 4327375 TI - Ultrastructure of the kidneys in experimental D3 hypervitaminosis. I. Ultrastructure of the cells of the main renal tubules in rats in experimental D 3 hypervitaminosis. PMID- 4327376 TI - Infantile neuroaxonal dystrophy or Seitelberger's disease. II. Peripheral nerve involvement: electron microscopic study in one case. PMID- 4327378 TI - Vesicular stomatitis virus, Indiana serotype: multiplication in and transmission by experimentally infected phlebotomine sandflies (Lutzomyia trapidoi). PMID- 4327377 TI - The risk of acute respiratory infections in two groups of young adults in Colombia, South America. A prospective seroepidemiologic study. PMID- 4327379 TI - Intra-arterial irradiation of tumors, a safe procedure. PMID- 4327380 TI - Angiography of trophoblastic tumors. A correlation of pelvic angiography with direct four-fold magnification angiography of uterine specimens. PMID- 4327381 TI - Acute stress ulceration with bleeding or perforation. PMID- 4327382 TI - Hepatic lobectomy. PMID- 4327383 TI - Morphologic changes of the liver following small intestinal bypass for obesity. PMID- 4327384 TI - Route of retrograde flow in the exocrine pancreas during ductal hypertension. PMID- 4327385 TI - Comparative biological effects of vitamins D 2 and D 3 and dihydrotachysterol 2 and dihydrotachysterol 3 in the chick. PMID- 4327386 TI - Synthesis of 5-fluorouridine 5'-phosphate by a pyrimidine phosphoribosyltransferase of mammalian origin. II. Correlation between the tumor levels of the enzyme and the 5-fluorouracil-promoted increase in survival of tumor-bearing mice. PMID- 4327388 TI - Effect of nerve stimulation and angiotensin on the accumulation of 3 H norepinephrine and the endogenous norepinephrine level in guinea pig vas deferens. PMID- 4327387 TI - Diazoxide, an inhibitor of succinate oxidation. PMID- 4327389 TI - Inhibition of inosinic acid dehydrogenase by 6-chloropurine nucleotide. PMID- 4327390 TI - Ethanol metabolism in the isolated, perfused rat liver. PMID- 4327391 TI - Alterations in specific transfer ribonucleic acids in a spectrum of hepatomas. PMID- 4327392 TI - Deoxyribonucleic acid polymerase with rat liver ribosomes and smooth membranes. Purification and properties of the enzymes. PMID- 4327393 TI - Studies on acid deoxyribonuclease. IX. 5'-Hydroxy-terminal and penultimate nucleotides of oligonucleotides obtained from calf thymus deoxyribonucleic acid. PMID- 4327395 TI - Interaction of metal ions with nucleic acids and related compounds. XVII. On the mechanism of degradation of polyribonucleotides and oligoribonucleotides by zinc(II) ions. PMID- 4327394 TI - Interaction of metal ions with nucleic acids and related compounds. XVI. Specific cleavage effects in the depolymerization of ribonucleic acids by zinc(II) ions. PMID- 4327396 TI - On the functional organization of the respiratory chain at the dehydrogenase coenzyme Q junction. PMID- 4327397 TI - Inhibition of mitochondrial energy-linked functions by arsenate. Evidence for a nonhydrolytic mode of inhibitor action. PMID- 4327398 TI - Purification and some properties of molybdoferredoxin, a component of nitrogenase from Clostridium pasteurianum. PMID- 4327399 TI - Chemical studies on the cyanogen bromide peptides of rat skin collagen. Amino acid sequence of 1-CB4. PMID- 4327400 TI - Preliminary studies on horse muscle acylphosphatase structure. Evidence of a mixed disulfide with glutathione. PMID- 4327401 TI - Oxygen-18 studies to determine the position of bond cleavage of acetyl phosphate in the presence of divalent metal ions. PMID- 4327402 TI - Effect of growth on the glycoproteins from the surface of control and Rous sarcoma virus transformed hamster cells. PMID- 4327404 TI - [Proteolipids of the white substance of different parts of the dog brain, spinal cord and sciatic nerve]. PMID- 4327403 TI - [Action of TSH on metabolism of thyroid phospholipids in vitro. Biphasic effect not reproduced by C-AMP and DBC]. PMID- 4327405 TI - [Synthesis of unsaturated phosphatidyl inosite]. PMID- 4327406 TI - [Some data of a morphological comparison of the hypophyses of Gobius melanostomus Pall. and Gobius batrachocephalus Pall. characterized by intermittent and single spawning]. PMID- 4327407 TI - [[Electron microscopic study of motor neurons during prolonged activation of afferent fibers]. PMID- 4327408 TI - [Results of pelvic arteriography with respect to placental tumors]. PMID- 4327409 TI - [Intravital diagnosis of pulmonary adenomatosis in 2 patients]. PMID- 4327410 TI - [Mediastinal synovioma]. PMID- 4327411 TI - [Primary pleural sarcoma]. PMID- 4327412 TI - [Metastasis of cancer from the cardiac portion of the stomach and choice of the extent of radical surgery]. PMID- 4327413 TI - [Diagnosis of adrenocortical insufficiency in patients with cardiovascular diseases]. PMID- 4327414 TI - [Control of the degree of muscle relaxation]. PMID- 4327415 TI - [The process of excitation and its transmission]. PMID- 4327416 TI - The production of mammalian virus antiserum in the domestic fowl. PMID- 4327417 TI - [Nosology and symptomatology of myocardia, myocarditis and endomyocardiopathies observed in Abidjan]. PMID- 4327418 TI - [Minimal partial resection in periphral bronchial carcinoma]. PMID- 4327419 TI - [Diagnostic possibilities in congenital infections]. PMID- 4327420 TI - [Introduction to the epidemiological study of hepatic cirrhosis (postnecrotic and Morgagni-Laennec) and of hepatocarcinomas in Minas Gerais, Brazil]. PMID- 4327421 TI - [Transformation of a normal differentiated cell of an adult organism, induced by the fusion of this cell with another normal cell of the same organism but with different organ or tissue specificity]. PMID- 4327423 TI - [The stimulating effect of chemical carcinogenic substances on cells in cultures]. PMID- 4327422 TI - [Morphologic changes in the ovaries in cancer of the uterine body]. PMID- 4327424 TI - [Anomalous antigens in experimental hepatocarcinogenesis]. PMID- 4327425 TI - [Lymphography and intralymphatic infusion of chemotherapeutic drugs in tumor patients]. PMID- 4327426 TI - Herpes genitalis in women attending Planned Parenthood of New York City. PMID- 4327427 TI - Cytologic features of pericardial mesothelium. PMID- 4327429 TI - Histochemical characteristics of cervical epithelia in rabbits and cattle. PMID- 4327428 TI - Urinary cytologic diagnosis of cytomegalic inclusion disease in childhood leukemia. PMID- 4327430 TI - Studies on the mouse mammary tumor agent (MTA). 3. Electrophoretic distribution of esterases. Glucose 6-phosphogluconate dehydrogenases in normal mammary gland of C57B1 and RIIIf and in virus induced and spontaneous mammary tumours in C57B1 and RIII mouse strain. PMID- 4327431 TI - Responses of isolated human uterine arteries to vasoactive drugs. PMID- 4327432 TI - Genital herpes in two social groups. PMID- 4327433 TI - Relationship of herpes simplex genital infection and carcinoma of the cervix: population studies. PMID- 4327434 TI - Malignant mixed mesodermal tumor of the uterus: an ultrastructural study. PMID- 4327435 TI - Inhibition of uterine motility by aminophylline. PMID- 4327436 TI - Antibacterial action of "broad-spectrum" penicillins, cephalosporins and other antibiotics against Gram-negative bacilli isolated from bacteremic patients. PMID- 4327437 TI - The role of antibiotics, vasoactive drugs and steroids in Gram-negative bacteremia. PMID- 4327438 TI - [Malignant evolution of mixed tumors]. PMID- 4327440 TI - The metabolism of 2-hydroxymuconic semialdehyde by Azotobacter species. PMID- 4327439 TI - [Effect of angiotensin II on an autorhythmic vascular smooth muscle (portal vein of the rat)]. PMID- 4327441 TI - The coexistence of two pathways for the metabolism of 2-hydroxymuconic semialdehyde in a naphthalene-grown pseudomonad. PMID- 4327442 TI - Thyrotropin releasing hormone: direct evidence for stimulation of prolactin production by pituitary cells in culture. PMID- 4327443 TI - Reversal of the effects of freezing on oxidative phosphorylation in the Mycobacterium phlei system. PMID- 4327444 TI - The interpretation of the EPR and Mossbauer spectra of two-iron, one-electron, iron-sulphur proteins. PMID- 4327445 TI - A note concerning the presence of an acid nucleoside triphosphatase in rat liver mitochondria. PMID- 4327446 TI - Effects of cholesterol and cholesterol derivatives on hydrocarbon chain mobility in lipids. PMID- 4327448 TI - Spin label orientation at the active site of -chymotrypsin in single crystals. PMID- 4327447 TI - Studies on the effect of distamycin A on the DNA dependent RNA polymerase system. PMID- 4327450 TI - Some fine structure features of meiosis in the yeast Saccharomyces cerevisiae. PMID- 4327449 TI - Effect of adrenalectomy and hypophysectomy on responses of rat liver enzymes to high-fructose diets. PMID- 4327451 TI - The lanthanide cations as probes in biological systems. Proton relaxation enhancement studies for model systems and lysozyme. PMID- 4327452 TI - The site of cytochrome oxidase biosynthesis in Neurospora crassa. PMID- 4327453 TI - Energy conversion in autotrophically grown Pseudomonas saccharophila. PMID- 4327454 TI - [Effect of substances used for neuroleptanalgesia on the synaptic transmission of stimulation in the spinal cord]. PMID- 4327455 TI - [Effect of alpha-adrenalytics on the vasoconstrictor reactions caused by stimulation of sympathetic nerves by noradrenaline and adrenaline]. PMID- 4327456 TI - [Effect of tranquilizing and antidepressive agents on the summation of impulses in the central nervous system]. PMID- 4327457 TI - [Study of antiviral effect of chlorine-substituted benzoquinine and hydroquinine]. PMID- 4327458 TI - [Study of the action of oxido-reductive enzymes in the liver of rats with chronic heliotrine poisoning]. PMID- 4327459 TI - [Brain scintigraphy and diagnosis of tumor type. Experience with RIHSA scintigraphy]. PMID- 4327460 TI - Cancer in Iran. Malignant tumors of the female genitalia. PMID- 4327461 TI - Primary malignant tumors of the ovary: analysis of 124 cases. PMID- 4327462 TI - Synthesis, intracellular transport, and discharge of secretory proteins in stimulated pancreatic exocrine cells. AB - Our previous observations on the synthesis and transport of secretory proteins in the pancreatic exocrine cell were made on pancreatic slices from starved guinea pigs and accordingly apply to the resting, unstimulated cell. Normally, however, the gland functions in cycles during which zymogen granules accumulate in the cell and are subsequently discharged from it in response to secretogogues. The present experiments were undertaken to determine if secretory stimuli applied in vitro result in adjustments in the rates of protein synthesis and/or of intracellular transport. To this intent pancreatic slices from starved animals were stimulated in vitro for 3 hr with 0.01 mM carbamylcholine. During the first hour of treatment the acinar lumen profile is markedly enlarged due to insertion of zymogen granule membranes into the apical plasmalemma accompanying exocytosis of the granule content. Between 2 and 3 hr of stimulation the luminal profile reverts to unstimulated dimensions while depletion of the granule population nears completion. The acinar cells in 3-hr stimulated slices are characterized by the virtual complete absence of typical condensing vacuoles and zymogen granules, contain a markedly enlarged Golgi complex consisting of numerous stacked cisternae and electron-opaque vesicles, and possess many small pleomorphic storage granules. Slices in this condition were pulse labeled with leucine-(3)H and the route and timetable of intracellular transport assessed during chase incubation by cell fractionation, electron microscope radioautography, and a discharge assay covering the entire secretory pathway. The results showed that the rate of protein synthesis, the rate of drainage of the rough-surfaced endoplasmic reticulum (RER) compartment, and the over-all transit time of secretory proteins through the cells was not accelerated by the secretogogue. Secretory stimulation did not lead to a rerouting of secretory proteins through the cell sap. In the resting cell, the secretory product is concentrated in condensing vacuoles and stored as a relatively homogeneous population of spherical zymogen granules. By contrast, in the stimulated cell, secretory proteins are initially concentrated in the flattened saccules of the enlarged Golgi complex and subsequently stored in numerous small storage granules before release. The results suggest that secretory stimuli applied in vitro primarily affect the discharge of secretory proteins and do not, directly or indirectly, influence their rates of synthesis and intracellular transport. PMID- 4327464 TI - The smooth muscle cell. II. Growth of smooth muscle in culture and formation of elastic fibers. AB - Smooth muscle derived from the inner media and intima of immature guinea pig aorta were grown for up to 8 wk in cell culture. The cells maintained the morphology of smooth muscle at all phases of their growth in culture. After growing to confluency, they grew in multiple overlapping layers. By 4 wk in culture, microfibrils (110 A) appeared within the spaces between the layers of cells. Basement membrane-like material also appeared adjacent to the cells. Analysis of the microfibrils showed that they have an amino acid composition similar to that of the microfibrillar protein of the intact elastic fiber. These investigations coupled with the radioautographic observations of the ability of aortic smooth muscle to synthesize and secrete extracellular proteins demonstrate that this cell is a connective tissue synthetic cell. PMID- 4327463 TI - The smooth muscle cell. I. In vivo synthesis of connective tissue proteins. AB - These studies have examined the ability of smooth muscle cells from developing aorta of the prepubertal rat to utilize amino acids in the synthesis and secretion of connective tissue proteins. Prepubertal rats, previously given either an alcohol carrier or estradiol-17-beta, were each given an intravenous injection of proline-(3)H. The animals were sacrificed after 15 and 30 min, and 4 hr. Light and electron microscope radioautographs of the aortic smooth muscle and of the myometrial cells demonstrated that the aortic cells, in both groups of animals, and the myometrial cells, in the estrogen-stimulated animals, took up the proline and rapidly secreted it in both collagen and elastic fibers within 4 hr. In contrast, the myometrial cells of the nonstimulated animal took up relatively small amounts of proline and retained most of the amino acid within the cells. Electron microscope radioautographs demonstrated that the organelles involved in this activity were the rough endoplasmic reticulum and Golgi complex together with peripheral elements, presumed to be small vesicles. These studies have demonstrated that the smooth muscle cells of the developing aorta and of the estrogen-stimulated myometrium have a capacity to synthesize and secrete proteins associated with the extracellular connective tissue matrix. PMID- 4327466 TI - Fine structure of the middle lamella of aggregates of plant cells in suspension culture. PMID- 4327465 TI - Tissue fractionation. Past and present. PMID- 4327467 TI - Vasoconstrictor in toxemia of pregnancy. PMID- 4327468 TI - Definition and morphologic features of chromosome pulverization: a hypothesis to explain the phenomenon. PMID- 4327469 TI - Aerosol transmission of Rauscher Murine Leukemia virus. PMID- 4327470 TI - Production of hepatomas in suckling mice after single application of propiolactone. PMID- 4327471 TI - So-called C marker chromosome and Epstein-Barr virus. PMID- 4327472 TI - [Mucinous carcinoma of the stomach and chronic lymphatic leukemia]. PMID- 4327473 TI - [A patient with 4 parasitic infections]. PMID- 4327475 TI - [Case of large mixed salivary gland tumor occurring in the right parapharyngeal space]. PMID- 4327474 TI - Fat cell size and lipid metabolism. PMID- 4327477 TI - [Pharmacology of hallucinogens]. PMID- 4327476 TI - The dependence of myocardial substrate levels on the arterial oxygen tension in the cat in vivo. PMID- 4327478 TI - [Comparative study of electric coupling between cells of normal liver and hepatomas]. PMID- 4327479 TI - [Treatment of gas gangrene in hyperbaric oxygenation chamber]. PMID- 4327480 TI - Biosynthesis of vitamin B 12 by Propionibacterium shermanii. IV. Vitamin B 12 and porphyrin synthesis in relation to the metabolic activities of the bacterium. PMID- 4327481 TI - The alkaloids of fungi. IV. Alkaloid biosynthesis in Aspergillus flavus. PMID- 4327483 TI - [The strychnine spike as a model for analysis of processes in the polysynaptic structures of the cerebral cortex]. PMID- 4327484 TI - [Post-hepatitic bone marrow aplasia]. PMID- 4327482 TI - Diseases of the external female genitalia--hidradenoma with light cells (light cell hidradenoma, clear cell hidradenoma) hidradenocarcinoma with light cells. PMID- 4327485 TI - [Apropos of a case of benign hepatoma]. PMID- 4327486 TI - [The bilharzian heart at Abidjan]. PMID- 4327487 TI - Production and secretion of chondroitin sulfates and dermatan sulfate by established mammalian cell lines. PMID- 4327488 TI - ACTH diazotized to agarose: effects on isolated adrenal cells. PMID- 4327490 TI - The extent of reversibility of the reaction. PMID- 4327489 TI - Generation of reducing power in bacterial photosynthesis. Rhodopseudomonas palustris. PMID- 4327491 TI - Some spectral properties of the human hemoglobin-haptoglobin complex. PMID- 4327492 TI - Circular dichroism and the conformations of membrane proteins. Studies with red blood cell membranes. PMID- 4327493 TI - Autoxidation of reduced pyridine coenzymes and of their models promoted by N,N,N',N'-tetramethyl-p-phenylenediamine. PMID- 4327494 TI - Interaction of metal ions with polynucleotides and related compounds. XIV. Nuclear magnetic resonance studies of the binding of copper(II) to adenine nucleotides. PMID- 4327495 TI - Comparative studies on mammalian and yeast phenylalanine transfer ribonucleic acids. PMID- 4327497 TI - Separation of Escherichia coli ribosomal ribonucleic acids by reversed-phase chromatography. PMID- 4327496 TI - Isolation and characterization of serine transfer ribonucleic acids from rat liver. PMID- 4327498 TI - [The electrical activity in the brain of white rats under conditions of free behavior]. PMID- 4327499 TI - [Circadian rhythm of wakefulness and sleep during narcolepsy]. PMID- 4327500 TI - [A comparison of the individual alpha-fetoproteins of human fetuses and patients with primary liver cancer]. PMID- 4327501 TI - [The blastomogenic effect of nitrosamines in mice]. PMID- 4327502 TI - [Proliferation dosage and threshold dosage of conjugated estrogens]. PMID- 4327503 TI - Radiation dose to the gastrointestinal tract of sheep fed an isoluble -emitter. PMID- 4327504 TI - [Current problems of rehabilitation following myocardial infarct]. PMID- 4327505 TI - [Intensive physical training as after-care and prevention of myocardial infarct]. PMID- 4327506 TI - Fatty acid and sterol composition of Mucor genevensis in relation to dimorphism and anaerobic growth. AB - Fatty acid and sterol content and composition were determined for the dimorphic mold, Mucor genevensis, grown under a variety of experimental conditions. Fatty acids account for 6 to 9% of the dry weight of aerobically grown mycelium, and 70 to 80% of these are unsaturated. The organism contains gamma-linolenic acid which is characteristic for Phycomycetes, and in sporangiospores this compound represents 40% of the total fatty acids. Of the sterols found in mycelium, 80% is ergosterol, and stigmasterol was positively identified as one of the minor components. In anaerobically grown yeastlike cells, sterol content is less than 10% of the level found in aerobically grown cells, and fatty acids amount to less than 2% of the dry weight. These fatty acids are predominantly short chain and less than 10% are unsaturated. Yeastlike cells obtained under aerobic conditions by growth in the presence of phenethyl alcohol have fatty acid and sterol compositions characteristic of aerobically grown mycelium. It is concluded that the dimorphology of the organism is not directly related to lipid composition. PMID- 4327507 TI - Lipid composition of some species of Arthrobacter. AB - The lipids from Arthrobacter crystallopoietes, A. pascens, and A. globiformis were investigated. Each strain contained three glycolipids, a monogalactosyl diglyceride, a digalactosyl diglyceride, and a dimannosyl diglyceride, and traces of triand tetraglycosyl diglycerides. The phospholipids in all three strains consisted of bisphosphatidylglycerol, phosphatidylglycerol, and phosphatidylmyoinositol. No evidence could be obtained for the occurrence of mannophosphoinositides. Analysis of the fatty acids by gas-liquid chromatography showed that they are predominantly C(15:0)anteiso and C(17:0)anteiso compounds. No significant differences were observed in the composition of lipids extracted from homogeneous cell preparations of the rod and sphere forms of A. crystallopoietes. PMID- 4327508 TI - Partial purification and properties of a highly specific trehalose phosphate phosphatase from Mycobacterium smegmatis. AB - A specific trehalose phosphate phosphatase was purified approximately 50-fold from Mycobacterium smegmatis. The enzyme had a pH optimum of about 7.0 and was stimulated by Mg(2+). The optimum concentration of Mg(2+) was about 1.5 x 10( 3)m. Of other divalent cations tested, only Co(2+) showed some activity. The K(m) for trehalose phosphate was found to be about 1.5 x 10(-3)m. The enzyme showed slight activity toward mannose-6-P and fructose-6-P but was inactive on a large number of other phosphorylated compounds. Citrate was a competitive inhibitor of the enzyme both with respect to trehalose phosphate concentration and Mg(2+) concentration. This inhibition appears to be due to chelation of Mg(2+) by this compound. Ethylenediaminetetraacetic acid and NaF were also inhibitors of the enzyme, but these inhibitions were noncompetitive. PMID- 4327510 TI - Characterization of the membrane-bound succinic dehydrogenase of Micrococcus lysodeikticus. AB - The occurrence of succinic dehydrogenase [succinic:(acceptor) oxidoreductase, EC 1.3.99.1] in membrane fractions of Micrococcus lysodeikticus was investigated. The enzyme could be purified 10-fold, by deoxycholate treatment. Butanol extraction of membranes yielded an active fraction, nonsedimentable at 130,000 x g for 2 hr and altered in its phospholipid content relative to membranes. The activity of the enzyme in particulate preparations was decreased in the presence of competitive inhibitors and by compounds known to react with iron, sulfhydryl groups, and flavine. In this respect, the bacterial succinic dehydrogenase is similar to the enzyme derived from yeast and mammalian sources. In certain membrane fractions, Ca(2+) and Mg(2+) exhibited inhibitory effects whereas Triton X-100 caused activation. The enzyme could also be activated by substrate. In the phenazine reductase assay, incomplete reduction of electron acceptor was observed upon addition of divalent cations and iron binding agents. PMID- 4327511 TI - Effect of shift-down and growth inhibition on phospholipid metabolism of Escherichia coli. AB - The metabolism of phospholipids of Escherichia coli was studied under conditions which inhibit various metabolic processes. Phospholipid synthesis and turnover were not inhibited by growth-inhibitory amounts of various antibiotics. Turnover of phosphatidylglycerol (PG) was inhibited by small amounts of dinitrophenol and by anaerobiosis. Turnover of phosphatidylethanolamine (PE), which is not detected in control cultures, was demonstrated under conditions of incipient lysis. When cells were shifted down from a rich to a poor medium, PE synthesis was inhibited, and incorporation of glycerol into the distal position of PG was stimulated. Under these conditions, turnover of the phosphate and the acylated glycerol moieties of PG was inhibited. Increased synthesis of PE was detected when filamentous cells were induced to make septa. The results indicate that PE synthesis is related to growth and cell division, whereas PG metabolism is related to other cell processes. PMID- 4327509 TI - Glucosylation of teichoic acid: solubilization and partial characterization of the uridine diphosphoglucose: polyglycerolteichoic acid glucosyl transferase from membranes of Bacillus subtilis. AB - Polyglycerolteichoic acid:glucosyl transferase (TAG transferase), one of the three enzymes involved in the pathway leading to the glucosylation of teichoic acid in Bacillus subtilis 168, was investigated. During the early stages of the growth of B. subtilis, TAG transferase is predominantly a soluble enzyme found in the cytoplasm. As growth proceeds, the amount of soluble enzyme decreases and the proportion of insoluble, membrane-bound TAG transferase increases, reaching a maximal value at the close of the logarithmic phase. Data are presented which suggest that these are two forms of the same enzyme, or have some common component. The effects of chaotropic agents, such as sodium trichloroacetate and sodium perchlorate, on the cytoplasmic membrane were also studied. These data show that such compounds can effectively remove the TAG transferase from the membrane in a water-soluble form. A study of some of the physical properties of this solubilized enzyme suggests that there is little difference between the two forms of the enzyme. Experiments are described which indicate that the glucosyl transfer by both the membrane-bound and soluble enzymes is not mediated by lipids. PMID- 4327512 TI - Hyperinducibility as a result of mutation in structural genes and self-catabolite repression in the ara operon. AB - Mutations in gene araB producing an l-arabinose-negative phenotype cause either an increase (hyperinducible), decrease (polar), or have no effect at all on the inducible rate of expression of the l-arabinose operon. Fourteen araB gene mutants exhibiting such effects were shown to be the result of: nonsense, frameshift, or missense mutations. All missense mutants were hyperinducible, exhibiting approximately a twofold increase in rate of l-arabinose isomerase production. All frameshift and most nonsense mutants exhibited polar effect. One nonsense mutant was hyperinducible. The cis-dominant polar effect of nonsense and frameshift mutants (as compared to induced wild type) were more pronounced in arabinose-utilizing merodiploids and in araBaraC(c) double mutants where inducible and constitutive enzyme levels are respectively determined. On the other hand, in arabinose-utilizing merodiploids, missense mutations no longer exhibited hyperinducibility but displayed a wild-type level of operon expression. Increases in the wild type-inducible rate of expression of the operon were found when growth rate was dependent on the concentration of l-arabinose. Cyclic 3',5' adenosine monophosphate also stimulated expression of the operon with the wild type in a mineral l-arabinose medium. These observations are explained on the basis that the steady-state expression of the l-arabinose operon OIBAD is dependent on the concentration of (i) l-arabinose, the effector of this system, which stimulates the expression of the operon, and (ii) catabolite repressors, produced from l-arabinose, which dampen the expression of the operon. We have termed the latter phenomenon "self-catabolite" repression. PMID- 4327513 TI - A cytological study of artificial parthenogenesis in the sea urchin Arbacia punctulata. AB - Eggs of the sea urchin Arbacia punctulata were artificially activated with hypertonic seawater. The artificially activated eggs undergo the cortical reaction which is not distinguished by a wavelike progression as in the case of inseminated eggs. The cortical granules are released at random loci at the surface of the egg and result in spaces separated by large cytoplasmic projections. Unreacted cortical granules and ribosomes are found within the matrix comprising the large cytoplasmic projections. No "fertilization cone" is formed. The subsequent release of additional cortical granules results in the formation of a continuous perivitelline space, 15 min following activation. 85 min postactivation, an organization of annulate lamellae, endoplasmic reticulum of the smooth variety, and microtubules around a centriole is observed prior to nuclear division. Before the breakdown of the nuclear envelope a streak stage is formed. The streak is composed of a central core of annulate lamellae and is encompassed by endoplasmic reticulum and vesicular components. Condensation of chromatin is followed by the establishment of the mitotic apparatus. Centrioles were not found in the mature egg; however, they are present after activation prior to the first nuclear division, in the four-cell embryo, multicellular embryo, and at blastula. Artificially activated eggs have been observed to develop to the pluteus stage in more than 50% of the eggs treated. PMID- 4327514 TI - The organization of contractile filaments in a mammalian smooth muscle. AB - Ordered arrays of thin filaments (65 A diameter) along with other apparently random arrangements of thin and thick filaments (100-200 A diameter) are observed in contracted guinea pig taenia coli rapidly fixed in glutaraldehyde. The thin filament arrays vary from a few to more than 100 filaments in each array. The arrays are scattered among isolated thin and thick filaments. Some arrays are regular such as hexagonal; other arrays tend to be circular. However, few examples of rosettes with regular arrangements of thin filaments surrounding thick filaments are seen. Optical transforms of electron micrographs of thin filament arrays give a nearest-neighbor spacing of the thin filaments in agreement with the "actin" filament spacing from x-ray diffraction experiments. Many thick filaments are closely associated with thin-filament arrays. Some thick filaments are hollow circles, although triangular shapes are also found. Thin filament arrays and thick filaments extend into the cell for distances of at least a micron. Partially relaxed taenia coli shows thin-filament arrays but few thick filaments. The suggestion that thick filaments aggregate prior to contraction and disaggregate during relaxation is promoted by these observations. The results suggest that a sliding filament mechanism operates in smooth muscle as well as in striated muscle. PMID- 4327515 TI - Glucocorticoid-induced alteration of the surface membrane of cultured hepatoma cells. AB - Glucocorticoids induce an alteration of the surface of hepatoma tissue culture (HTC) cells as expressed by changes in cell electrophoretic, antigenic, and adhesive properties. The alteration is assayed by the increased adhesiveness of induced cells for a glass surface. The induction process has a lag period of about 3 hr and attains a plateau level after 24-30 hr when 50-80% of the steroid treated cells are firmly adhered. Less than 10% of untreated cells adhere under the same conditions. Induction is inhibited by actinomycin D and cycloheximide, demonstrates both pH and temperature dependence, and responds to changes in steroid concentration and structure. By contrast, the attachment per se of preinduced cells is not affected by inhibitors of RNA and protein synthesis, fluctuations of temperature and pH, and the presence or absence of the hormone. When the induction process is reversed by removal of steroid or addition of actinomycin D, preinduced adhesiveness is lost with a half-life of 13-24 hr, but in the presence of cycloheximide the loss is accelerated (t(1/2) 3-5.5 hr). These results suggest that glucocorticoids induce the biosynthesis of a protein which either modifies the cell surface (an enzyme) or is incorporated into surface structures (structural protein). PMID- 4327516 TI - The permeability of dragonfly malpighian tubule cells to protein using horseradish peroxidase as a tracer. PMID- 4327517 TI - Comparison between 3,3'-diaminobenzidine and auto-oxidized 3,3 '-diaminobenzidine in the cytochemical demonstration of oxidative enzymes. PMID- 4327518 TI - Mucinous carcinoma of the ileum in the rat. PMID- 4327519 TI - Yoga foot drop. PMID- 4327520 TI - [Therapy of acute viral hepatitis]. PMID- 4327521 TI - [Cortrosyn depot for treatment of asthmatic children]. PMID- 4327522 TI - [The endolymphatic therapy using 131-I-lipiodol. Kinetics, indication and technic]. PMID- 4327523 TI - [Use of the electron microscope in the diagnosis of obscure virus infection s. Herpesvirus encephalitis and post-vaccinal keratitis]. PMID- 4327524 TI - [Etiologic studies of virus infections in calf and cattle husbandry]. PMID- 4327525 TI - [Study of the pulmonary dusting by electron microscopy and micro-analyzer with electric probe]. PMID- 4327526 TI - [Fulgurant pains. Etiology and physiopathology]. PMID- 4327527 TI - Coronary inactivation of angiotensins. PMID- 4327528 TI - [A case of total peripheral delabyrinthization of metastatic origin, 25 years after a breast cancer]. PMID- 4327530 TI - [Ribonuclease of histones in liver and hepatoma]. PMID- 4327529 TI - Contraction of granulation tissue in vitro: similarity to smooth muscle. AB - Strips of granulation tissue from three different experimental models contract in vitro when treated with substances that induce contraction of smooth muscle. Because the fibroblasts in such tissues have some ultrastructural features typical of smooth muscle, our findings indicate that fibroblasts are able to modulate toward a cell type that is morphologically and functionally close to smooth muscle. PMID- 4327531 TI - [Ultrastructural features of the terminal blood vessel system under various physiological and pathological influences]. PMID- 4327532 TI - [Histoenzymatic activity of the rat heart muscle during pre- and post-natal development]. PMID- 4327533 TI - [Electron microscope studies on the effect of synthalin A on the islet system and adrenal gland of the duck]. PMID- 4327534 TI - ["Red" muscle fibres]. PMID- 4327535 TI - Ultrastructure of germ cell development in the human fetal testis. PMID- 4327536 TI - Cytology of the neuro-intermediate lobe of the tuatara, Sphenodon punctatus Gray. PMID- 4327537 TI - Oogenesis in a braconid, Apanteles glomeratus (L.) possessing an hydropic type of egg. PMID- 4327538 TI - The fine structure of the granulosa cells in the domestic fowl and the rat. PMID- 4327539 TI - [Convergence of visceral and somatic afferent influences on the neurons of the ventro-posterior thalamic nucleus]. PMID- 4327541 TI - Radiological case of the month. Hypophosphatasia in the newborn. PMID- 4327540 TI - Stimulation of bacitracin production in the mixed cultures of Bacillus subtilis and Pseudomonas sp. PMID- 4327542 TI - [Mechanism of action of angiotensin II on the arterial smooth muscular cell]. PMID- 4327543 TI - [Automatic preparative disk electrophoresis with controlled elution]. PMID- 4327544 TI - [Degenerate familial rectocolic polyposis: htree cases]. PMID- 4327545 TI - [Infectivity for mice of the ribonucleic acid extracted from chicken sarcoma induced by the Carr (Zilber) strain of Rous sarcoma virus (RSV-Carr-Zilber-RNA). I. Morphological study]. PMID- 4327546 TI - Enzyme histochemistryy in Shope papilloma. Histochemical observations of enzymes in Shope papillomatosis of the rabbit skin. PMID- 4327548 TI - Variations in motor nerve conduction velocity in normal and uremic patients. PMID- 4327547 TI - Evaluation of equilin 3-monosulfate and other estrogens. Comparison by study of urinary gonadotropins in women. PMID- 4327549 TI - Superinfection of an amoebic abscess by Salmonella enteritidis. PMID- 4327550 TI - [Animal experimental studies in the lung on the problem of retention and elimination of calcium fluoride. (Pneumoconiosis of fluorspar-workers)]. PMID- 4327551 TI - [Study by fluorescence of the binding of TNS with horse liver alcohol dehydrogenase (HLADH)]. PMID- 4327552 TI - [Kinetics of the incorporation of uridine ( 3 H) in subnucleolar fractions of rat ascites hepatoma cells]. PMID- 4327553 TI - Importance of Mn ++ in the regulation of gluconeogenesis in cellular and acellular kidney cortex systems: new data on mechanism of action of biguanides. PMID- 4327554 TI - [Kinetics of the biosynthesis of chicken brain phosphatides during the embryonic and postnatal periods]. PMID- 4327555 TI - Intranuclear inclusions in neurons of the cat primary olfactory system. PMID- 4327556 TI - [Thermographic symptomatology of mammary epitheliomas]. PMID- 4327557 TI - [Surgical treatment of the sacral dermoid using a new modified marsupialisation method]. PMID- 4327558 TI - Renal vasodilatation: effect on renal handling of phosphate. PMID- 4327559 TI - The measurable effect of low concentrations (pg-ml) of ACTH on reducing groups of adrenal cortex maintained in organ culture. PMID- 4327560 TI - The intramedullary connections of the area postrema involved in the central cardiovascular response to angiotensin II. PMID- 4327561 TI - Reversible inhibition of DNA synthesis by the arginine analogue canavanine in hamster and mouse cells in vitro. PMID- 4327562 TI - Stimulation of DNA synthesis and mitotic activity of thymic lymphocytes by cyclic adenosine 3'5'-monophosphate. PMID- 4327563 TI - Structural changes in Euglena gracilis grown autotrophically in the light with 3,(3,4-dichlorophenyl)-1, 1-dimethyl urea (DCMU). PMID- 4327564 TI - Changes in fine structure during cell differentiation of the cellular slime mould Dictyostelium discoideum. PMID- 4327565 TI - Changes in enzyme levels accompanying differentiation of intestinal epithelial cells. PMID- 4327566 TI - Relationship between membrane potential and metabolic activity of osteoclasts. PMID- 4327567 TI - Induction of rhabdomyosarcomas in mammals with a highly oncogenic variant of Rous sarcoma virus. PMID- 4327568 TI - [Recurring brain metastases of a sweat gland neoplasm]. PMID- 4327569 TI - 45,XO Turner's syndrome, Wilm's tumor and imprforate anus. PMID- 4327570 TI - Symposium on microbial changes in foods. Factors affecting the production of bacterial food poisoning toxins. PMID- 4327571 TI - The formation of multivesicular bodies from the nuclear envelope. AB - Cells of the gas gland of the perch Perca fluviatilis L., stimulated to increased generation of gas by the repeated emptying of the swim-bladder, were examined in the electron microscope. Intense activity of the nuclear envelope was demonstrated. Simple vesicles originating from the external nuclear membrane and the so-called multivesicular bodies derived from the outpocketings of both membranes of the nuclear envelope were observed. The multivesicular bodies were filled with numerous fine vesiculae arising from the active proliferation of their internal membrane. The authors offer two alternative mechanisms of formation of fine vesiculae inside the multivesicular bodies and the mechanism of the tearing away of these bodies from the nuclear envelope. PMID- 4327572 TI - Intercellular migration of centrioles in the germarium of Drosophila melanogaster. An electron microscopic study. AB - A cluster of centrioles has been found in the early Drosophila oocyte. Since the oocyte is connected to 15 nurse cells by a system of intercellular bridges or ring canals, the possibility that the cluster of centrioles arose in the germarium from an intercellular migration of centrioles from the nurse cells to the oocyte was analyzed in serial sections for the electron microscope. Initially, all of the 16 cells of the future egg chambers possess centrioles, which are located in a juxtanuclear position. At the time the 16 cell cluster becomes arranged in a lens-shaped layer laterally across the germarium, the centrioles lose their juxtanuclear position and move towards the oocyte. By the time the 16 cell cluster of cells is surrounded by follicle cells (Stage 1), between 14 and 17 centrioles are found in the oocyte. Later, these centrioles become located between the oocyte nucleus and the follicle cell border and become aggregated into a cluster less than 1.5 micro in its largest dimension. The fate of these centrioles in the oocyte is not known. The fine structure of the germarium and the early oocyte is also described. PMID- 4327573 TI - Lysosomes in skeletal muscle tissue. Zonal centrifugation evidence for multiple cellular sources. AB - Postnuclear supernates from homogenates of skeletal muscle from rats subjected to starvation, injections of Triton WR-1339, dextran-500, and dextran + corticosterone were fractionated by means of rate and isopycnic zonal centrifugation in sucrose-0.02 M KCl gradients. Zonal fractions were analyzed for protein, RNA, cytochrome oxidase, and up to six acid hydrolases. The results indicate the presence of two groups of lysosome-like particles. One group contributes approximately 95% of the cathepsin D and acid phosphatase activity and 75% of the acid ribonuclease, beta-glucuronidase, and arylsulfatase activity in muscle. It is characterized by a modal equilibrium density of 1.18 that is decreased by starvation, but is not shifted by dextran-500 or Triton WR-1339. The second group has a higher proportion of acid ribonuclease, beta-glucuronidase, and arylsulftase; the equilibrium density can be shifted by dextran-500 and Triton WR-1339. It is suggested that this group of lysosomes is derived from macrophages and other connective tissue cells, whereas the former group represents lysosome-like particles from muscle cells. PMID- 4327574 TI - Ultrastructure of bacterized and axenic trophozoites of Entamoeba histolytica with particular reference to helical bodies. AB - Electron microscopy of bacterized and axenic trophozoites of Entamoeba histolytica showed only slight differences in ultrastructure between the two. As with other species of Entamoeba so far studied, this species lacks typical mitochondrial structures and formed endoplasmic reticulum. Dense clusters of glycogen particles are especially characteristic in axenic amebas. Microtubular structures 360 A in diameter appear randomly oriented in both bacterized and axenic trophozoites. Ribonucleoprotein (RNP) bodies are of two typical forms elongate, parallel arrays of helices (the classical chromatoid bodies), and short helical fragments. Both kinds of helix show a recurring pitch angle of 68-80 degrees and an over-all diameter of 480 A. RNP particles comprising the helices average 180 A in diameter. The longitudinal axes of adjacent helices are 440 A apart. Following RNase digestion of water-soluble methacrylate sections, helices show a core approximately 60 A in diameter. Short helices are also associated with digestive vacuoles. Free RNP particles per se are never seen within digestive vacuoles, but intact short helices are frequently detected closely associated with the external membrane of digestive vacuoles. In some cases, continuation of externally intact helical forms could be related to filamentous material within the vacuole. Acid phosphomonoesterase activity could be demonstrated within digestive vacuoles where deposition of reaction product is especially intense on the filamentous material. PMID- 4327575 TI - The effect of ketone bodies on renal ammoniogenesis. AB - Infusion of ketone bodies to ammonium chloride-loaded acidotic dogs was found to induce significant reduction in urinary excretion of ammonia. This effect could not be attributed to urinary pH variations. Total ammonia production by the left kidney was measured in 25 animals infused during 90 min with the sodium salt of D,L-beta-hydroxybutyric acid adjusted to pH 6.0 or 4.2. Ketonemia averaged 4.5 mM/liter. In all experiments the ammonia content of both urine and renal venous blood fell markedly so that ammoniogenesis was depressed by 60% or more within 60 min after the onset of infusion. Administration of equimolar quantities of sodium acetoacetate adjusted to pH 6.0 resulted in a 50% decrease in renal ammonia production. Infusion of ketone bodies adjusted to pH 6.0 is usually accompanied by a small increase in extracellular bicarbonate (3.7 mM/liter). However infusion of D,L-sodium lactate or sodium bicarbonate in amounts sufficient to induce a similar rise in plasma bicarbonate resulted in only a slight decrement in ammonia production (15%). The continuous infusion of 5% mannitol alone during 90-150 min failed to influence renal ammoniogenesis. Infusion of pure sodium-free beta hydroxybutyric acid prepared by ion exchange (pH 2.2) resulted in a 50% decrease in renal ammoniogenesis in spite of the fact that both urinary pH and plasma bicarbonate fell significantly. During all experiments where ketones were infused, the renal extraction of glutamine became negligible as the renal glutamine arteriovenous difference was abolished. Renal hemodynamics did not vary significantly. Infusion of beta-hydroxybutyrate into the left renal artery resulted in a rapid decrease in ammoniogenesis by the perfused kidney. The present study indicates that ketone bodies exert their inhibitory influence within the renal tubular cell. Since their effect is independent of urinary or systemic acid-base changes, it is suggested that they depress renal ammoniogenesis by preventing the transformation of glutamine and glutamate into alpha-ketoglutarate in the mitochondria of the renal tubular cell. PMID- 4327576 TI - Direct measurement of proinsulin in human plasma by the use of an insulin degrading enzyme. AB - A method has been described for the direct measurement of proinsulin in human plasma. The method makes use of an insulin-degrading enzyme designated "insulin specific protease (ISP)", which is obtained from rat skeletal muscle. Under the conditions used, this enzyme rapidly degrades insulin and insulin-like polypeptides to nonimmunoassayable components, whereas proinsulin and proinsulin cleaved at position B(54,55) are not appreciably affected. The incubation of plasma with ISP results in the disappearance of insulin, but not proinsulin, as demonstrated by column chromatography. Immunoassay of the plasma, therefore, before and after incubation, determines the values for the total immunoreactive substance (TIR) and for immunoreactive proinsulin (IRP), respectively. The values obtained for proinsulin levels are reproducible and compare closely with the more complicated column fractionation methods. Proinsulin responses were studied in four normal subjects and one patient with an insulinoma after a glucose load. Fasting proinsulin levels varied widely in the normal subjects, and the levels rose more slowly than TIR levels after glucose. IRP levels in the patient with an insulinoma were very high and fell to normal after removal of the tumor. The ISP method, therefore, appears to be suitable for the direct, accurate, and rapid determination of proinsulin and proinsulin-like materials in human plasma. PMID- 4327578 TI - Effects of prepubertal orchidectomy on the differentiation of prolactin cells in the mouse adenohypophysis. A quantitative study by electron microscopy. PMID- 4327577 TI - Observations on the responsiveness of human subjects to human growth hormone. Effects of endogenous growth hormone deficiency and myotinic dystrophy. AB - The effect of human growth hormone (HGH) on the N, P, Na, and K balance, and on the body weight (BW) of three groups of subjects was measured. In group I were nine cases (age 6-69) with HGH deficiency; in group II, eight cases (age 9-79) with normal endogenous HGH; in group III, four cases with myotonic dystrophy (age 45-51). After a 7 day control period, the hormone was administered for 7 days. Each subject was tested with three doses of HGH: dose A, 0.0168 U/kg BW(3/4) per day; dose B, 0.0532 U/kg BW(3/4) per day; dose C, 0.168 U/kg BW(3/4) per day. In group I, the responsiveness to HGH declined with age. Two subjects aged 6 yr responded to all three doses of HGH with positive balances in N, P, Na, and K and increases in BW. At ages 15-17, responses were obtained only to doses B and C in three cases, and only to dose C in two cases. Two subjects, aged 42 and 69, responded only to dose C. Not only did the threshold dose increase with age in group I, but the magnitude of the responses declined with age as well.Patients of group II were less responsive to all doses of HGH than were patients of group I at comparable age. None responded to dose A or dose B. All responded to dose C, but the increments in balances and in BW stimulated by this dose were only one third to one-half as great as in HGH-deficient subjects of similar age. Three patients of group III responded to all three doses of HGH, and one responded to doses B and C. The responses were similar in magnitude to those in the 6-yr old HGH-deficient children, and greater than those in all other subjects studied. These data show that responsiveness to exogenous HGH rises with deficiency of endogenous HGH, and that individuals with myotonic dystrophy are hyperresponsive to exogenous HGH. PMID- 4327579 TI - Differential release of individual gonadotrophins by the human foetal pituitary gland after stimulation by cyclic AMP and sodium fluoride. PMID- 4327580 TI - The homologies of spontaneous and induced temperature-sensitive mutants of vesicular stomatitis virus isolated in chick embryo and BHK 21 cells. PMID- 4327581 TI - Ovarian teratoma containing arrhenoblastic tissue. PMID- 4327583 TI - Growth of murine cytomegalovirus in various cell lines. AB - Murine cytomegalovirus (MCMV) was capable of infecting and replicating in both primary and continuous cell lines obtained from various species. In African green monkey kidney (BSC-1) cells, primary rabbit kidney cells, and baby hamster kidney (BHK-21) cells, there were cytopathic effects (CPE) and virus replication upon initial exposure of cells to virus. In primary fetal sheep brain (FSB) cells, L cells, and rabbit kidney (RK-13) cells, it was necessary to subculture the infected cells one or more times before appearance of CPE and replication of virus. In the case of the infected FSB cultures, it was found that the virus effect could be induced if subculturing were accomplished by trypsinization but did not occur if cells were subcultured by scraping. FSB-grown virus replicated better in FSB than in mouse embryo fibroblast (MEF) cells. The CPE produced in all of the above cell lines was similar to that observed in MEF infected with MCMV. The virus grown in different cell lines was completely neutralized when mixed with several reference sera prepared in rabbits or mice. The populations of virions released from infected MEF and FSB cells were compared by isopycnic centrifugation in potassium tartrate, and no differences were revealed in the buoyant densities of the populations. Human embryonic brain cells, human embryonic kidney cells, a human lung fibroblast cell strain (WI-38), HeLa, and Hep-2 were not susceptible to MCMV. PMID- 4327582 TI - Virus interference by cellular double-stranded ribonucleic acid. AB - Ribonuclease-resistant ribonucleic acid (RNA) was isolated from uridine-labeled cultures of rabbit kidney, chicken embryo, and HeLa cells. This RNA, regardless of its source, was found to induce interference with virus growth in either rabbit kidney or chicken embryo cultures. Nuclease-treated cellular nucleic acids exhibited interference-inducing activity which eluted with a small fraction of RNA in the exclusion volume of a 6% agarose gel column. Besides resistance to ribonucleases, the interference inducer and RNA isolated from partially digested nucleic acids have in common two properties of double-stranded RNA: (i) similar sharp melting profiles were obtained for inducer and ribonuclease-resistant RNA, with T(m) dependent on NaCl concentration; (ii) ribonuclease-resistant inducer and RNA banded together in Cs(2)SO(4) density gradients at a density characteristic of known double-stranded RNA. After melting at low ionic strength, the labeled RNA shifted to a higher density and its capacity to inhibit virus replication was lost. Velocity sedimentation analysis of the cellular ribonuclease-resistant RNA indicated that the majority sedimented between 7 and 11S, but only RNA sedimenting at >==8 to 20S had a high specific activity of interference induction. Without prior ribonuclease treatment, the ribonuclease resistant RNA can be precipitated with 2 m LiCl and thus appears to exist in purified cellular nucleic acids as part of molecular complexes with both single- and double-stranded regions of RNA. The biosynthesis of cellular double-stranded RNA is inhibited by actinomycin D. PMID- 4327584 TI - Analysis of the fusion of XC cells induced by homogenates of murine leukemia virus-infected cells and by purified murine leukemia virus. AB - The fusion of XC cells induced by murine leukemia virus (MuLV)-infected cells is also induced by homogenates prepared from the infected cells and by purified MuLV. The fusion-inducing factor appears to contain a heat-labile lipoprotein. No synthesis of specific macromolecules by the XC cells is necessary to obtain fusion. The results suggest that specific components of the viral particle are the activators for the fusion process and they may also be present in the membranes of infected cells. PMID- 4327585 TI - Susceptibility of differentiating muscle cells of the fetal mouse in culture to coxsackievirus A13. AB - The interaction of coxsackievirus A13 with differentiating muscle cells, cultured from tissues of the fetal mouse, was studied. Cultures infected at that stage of myogenic differentiation characterized by the rapid formation of multinucleated myotubes produced maximum virus titers of over 10(7) plaque-forming units. Virus induced cytopathic effect was characterized by a marked diminution in the number of multinucleated cells. The susceptibility of these cultures decreased appreciably when infection was initiated after the majority of the myotubes had formed. The demonstration of newly synthesized A13 virus antigen by immunofluorescence provided direct evidence that A13 virus replication occurred both in myoblasts and myotubes. The synthesis of A13 virus was markedly depressed in muscle cultures in which the formation of multinucleated cells was inhibited by BUDR or by fusion-inhibiting media. After reversal of this inhibition, the cultures acquired the increased susceptibility to A13 virus characteristic of cells undergoing myogenic differentiation. In contrast to the results obtained with coxsackievirus A13, the primary fetal mouse muscle cultures were resistant to poliovirus T1. It is suggested that changes in the surfaces of developing muscle cells may coincide with the formation and disappearance of specific virus receptors and thereby regulate the cell susceptibility to coxsackievirus A13. PMID- 4327586 TI - Deoxyribonucleic acid synthesis in synchronized mammalian KB cells infected with herpes simplex virus. AB - We examined the patterns of host cell and virus deoxyribonucleic acid (DNA) synthesis in synchronized cultures of KB cells infected at different stages of the cell cycle with herpes simplex virus (HSV). We found that the initiation of HSV DNA synthesis, we well as the production of new infectious virus, is independent of the S, G1, and G2 phases of the mitotic cycle of the host cell. This is in contrast to data previously found with equine abortion virus. Because HSV replicates independently of the cell cycle, we were able to establish conditions that would permit the study of rates of HSV DNA synthesized in logarithmically growing cells in the virtual absence of cellular DNA synthesis. This eliminates the need for separation of viral and cellular DNA by isopycnic centrifugation in CsCl. We found that HSV DNA synthesis was initiated between 2 to 3 hr after infection. The rate of DNA synthesis increased rapidly, reaching a maximum 4 hr after infection, and decreased to 50% of maximum by 8 hr. Evidence is also presented which suggests that HSV infection can inhibit both the ongoing synthesis of host DNA as well as the initiation of the S phase. PMID- 4327587 TI - Priming: a nonantiviral function of interferon. AB - No interferon is made by L cells when they are infected with MM virus. However, several thousand units of interferon are produced when interferon-treated L cells are infected with MM virus. We call the conversion of cells, from nonproducers to producers, priming. The time required for cells to become fully primed is dependent on the interferon concentration with which they are incubated. Primed cells produced interferon earlier than normal cells stimulated by other inducers. Cells which were exposed to interferon in the presence of inhibitors of protein synthesis became fully primed yet developed no virus resistance. Also, primed cells produced interferon in response to low concentrations of polyriboinosinic acid . polyribocytidylic acid that did not induce interferon in normal cells. Therefore, priming appears to be a function of interferon separable from its antiviral activity. Several other picornaviruses that failed to induce interferon in L cells, human embryonic lung cells, or monkey kidney cells did induce interferon when these cells had been primed by homologous interferons. PMID- 4327588 TI - Multiplication of polyoma virus in mouse-hamster somatic hybrids: a hybrid cell line which produces viral particles containing predominantly host deoxyribonucleic acid. AB - The multiplication of polyoma virus in a mouse-hamster (3T3 x BHK) somatic hybrid line (10A), which, although permissive for viral multiplication, produces very low amounts of virus, has been studied. In this cell line, the efficiency of productive infection is high, but the yield of infectious virus is on the order of 0.5% of that of 3T3 cells. The amount of viral deoxyribonucleic acid (DNA) synthesized by these cells upon infection is about 5% of that of 3T3 cells. An examination of the virus produced in hybrid 10A revealed that it was only one tenth as infectious as the virus grown in 3T3. Although the viral DNA synthesized in the infected 10A cells is normal, the DNA extracted from purified virus grown in 10A consists of approximately 10% of normal, supercoiled polyoma DNA molecules and of approximately 90% linear DNA molecules with a sedimentation coefficient of 14 to 16S. These DNA molecules appear to be of cellular origin but contain a limited amount of viral DNA sequences. The host DNA-containing particles are not infectious but appear to possess some biological activity; they give rise to a weak complementation effect, and part of them are able to induce T-antigen synthesis. In addition, the host DNA present in these particles is predominantly that which has been synthesized after infection. The correlation between the block in viral DNA synthesis in this cell line and the abnormal encapsidation of host DNA is discussed. PMID- 4327589 TI - Transfer of thymidine kinase to thymidine kinaseless L cells by infection with ultraviolet-irradiated herpes simplex virus. AB - L cells lacking thymidine kinase (TK) activity (Ltk(-) cells) have been stably transformed to a TK-positive phenotype by infection with ultraviolet-irradiated herpes simplex virus (HSV-UV). The highest frequency of the Ltk(-) to Ltk(+) transformation observed in these experiments was approximately 10(-3), whereas no measurable transformation was observed (less than 10(-8)) in the absence of HSV UV infection. Cell lines of HSV-transformed Ltk(+) cell lines contain 7 to 24 times as much TK activity as do the parental Ltk(-) cells, and they have been maintained in culture for a period exceeding 8 months. The kinetics of thermal inactivation of the TK activity derived from an Ltk(+) HSV-transformed cell line and the TK activity from Ltk(-) cells lytically infected with infectious HSV are similar. Both of these TK activities are much more thermolabile than the TK activity present in wild-type L cells. A mutant strain of HSV which does not induce TK activity during lytic infection does not cause the Ltk(-) to Ltk(+) transformation. These data suggest that either an HSV TK gene has been transferred to Ltk(-) cells or that an HSV gene product has caused the expression of a previously repressed cellular enzyme. PMID- 4327591 TI - Nature of oestrogen specific binding sites in the nuclei of mouse uteri. PMID- 4327590 TI - Linear, single-stranded deoxyribonucleic acid isolated from Kilham rat virus. AB - Kilham rat virus (KRV) was grown in a rat nephroma cell line and was purified by two isopycnic centrifugations in cesium chloride. The virus contains single stranded deoxyribonucleic acid (DNA) with a molecular weight of approximately 1.6 x 10(6). The DNA was extracted from the virion by both phenol extraction and by 2% sodium dodecyl sulfate at 50 C. KRV DNA, extracted by both procedures, was observed in an electron microscope by using a cytochrome c or diethylaminoethyldextran monolayer. The DNA was also exposed to exonuclease I, an enzyme which hydrolyzes specifically linear, single-stranded DNA. Hydrolysis of 70 to 80% of the DNA was observed. Both the enzymatic and the electron microscope studies support the conclusion that extracted KRV DNA is a single-stranded, linear molecule. The length of the DNA was measured in the electron microscope and determined to be 1.505 +/- 0.206 mum. PMID- 4327592 TI - [Is the long term care of schizophrenic patients necessary?]. PMID- 4327593 TI - [Electron microscopic study of bronchial carcinoids and of anaplastic small cell cancers]. PMID- 4327595 TI - Medullary carcinoma of the thyroid gland. PMID- 4327594 TI - Polyneuritis associated with cytomegalovirus infections. PMID- 4327596 TI - Studies on mice of a tumor resistant strain (X-Gf). 8. Type C particles in mammary tumors of Friend leukemia virus-infected mice. PMID- 4327597 TI - Determination of antibiotic sensitivities of gram-negative bacilli (comparison of single-disc and inocula-replicating methods). PMID- 4327598 TI - Transformation of lymphocytes from patients with recurrent aphtae. PMID- 4327599 TI - [Day sleep and experimental sensory deprivation: data concerning the "eye movement phase"]. PMID- 4327600 TI - Neuronal circuit mediating escape responses in crayfish. AB - The neuronal circuit underlying rapid abdominal flexion in response to phasic tactile stimulation comprises identified afferents, interneurons of two orders, a decision unit, and several motor neurons. The circuit is organized hierarchically as a " cascade" in which electrical synapses predominate at higher levels. Behavioral habituation results from lability at chemical junctions early in the pathway. PMID- 4327601 TI - [Tinnitus]. PMID- 4327602 TI - [Rheumatoid polyarthritis with diffuse arteritis. Dissociated action of penicillamine]. PMID- 4327603 TI - [Amyloidosis revealing plasmacytic cryptoleukosis in a pregnant woman. Anatomic and clinical study]. PMID- 4327604 TI - [Iodinated thyroid hormones and phosphocalcic metabolism]. PMID- 4327605 TI - [The general physician facing the computer world]. PMID- 4327606 TI - [Administration of the National Health Insurance Fund. (Report of the Inspection Generale des Affaires Sociales)]. PMID- 4327607 TI - The role of tumour viruses in basic research and medicine. PMID- 4327608 TI - The uniqueness of human milk. Host resistance to infection. PMID- 4327609 TI - Specific assay of aminoglycosidic- or polymyxin-type antibiotics present in human sera in combination with cephalosporins. AB - Monitoring of serum concentrations of aminoglycosidic or polymyxin antibiotics when administered concurrently with cephalosporins or penicillins requires a special assay technique. Selective enzymatic degradation of the beta-lactam antibiotic from the serum specimen allows subsequent assay of the antibiotic being monitored. This report gives details of a simple procedure for laboratory production of a crude enzyme capable of degrading cephalosporins or penicillins. An assay procedure for quantitating aminoglycosidic or polymyxin antibiotics after enzymatic degradation of a coexisting beta-lactam antibiotic is described. PMID- 4327610 TI - Preparative electrophoresis of isotopically labeled L-cell interferons. AB - The preparative method of polyacrylamide gel electrophoresis was adapted for purification and characterization of isotopically labeled L-cell interferons. Re covery of interferon activity was quantitative, and purification and resolution were comparable to those obtained by analytical polyacrylamide gel electrophoresis. Ultimate specific activities attainable ranged from 2 x 10(6) to 3 x 10(6) international units per mg of protein. PMID- 4327611 TI - Carbohydrate fermentation patterns of Neisseria meningitidis determined by a microtiter method. AB - A carbohydrate fermentation technique has been developed and compared to the standard fermentation test with cystine-Trypticase-semisolid agar for the identification of Neisseria meningitidis. This new method utilizes Mueller-Hinton broth as a basal substrate and is performed with microtiter methods. By using Mueller-Hinton broth with and without the addition of antibiotics, the method can be adjusted to test the fermentation patterns of all of the Neisseria including N. gonorrhoeae. PMID- 4327612 TI - Influence of Na+ on synthesis of macromolecules by a marine bacterium. AB - Resting cells of Vibrio natriegens acquired the ability to take up (14)C-labeled mannitol in media containing Na(+) and K(+). But, the cells took up a significant quantity of the label as well in the presence of 0.3 m K(+) and no Na(+). The label was distributed throughout the cells in both systems. Cells incubated in mannitol minimal culture medium proliferated and synthesized approximately nine times as much protein in the presence of Na(+) and K(+) as those incubated in the presence of mannitol and 0.3 m K(+). The bacteria did not proliferate in the absence of Na(+). Cells incubated in medium containing mannitol and Na(+) and K(+) synthesized approximately twice the quantity of deoxyribonucleic acid and ribonucleic acid as those incubated in medium containing mannitol and 0.3 m K(+) but no Na(+). A significant amount of mannitolbinding protein was synthesized in the membranes of V. natriegens incubated in the presence of mannitol and Na(+) and K(+), but only a small quantity was produced in medium containing mannitol and 0.3 m K(+) but no Na(+). A binding fraction comprising at least two proteins (both with molecular weight near 34,000) was isolated by gel electrophoresis from other components of a K(2)CO(3)-extract of membrane protein from mannitol-grown cells. This binding fraction mediated phosphorylation of mannitol at the expense of either adenosine triphosphate or phosphoenolpyruvate. It was then found that mannitol-grown, but not broth-grown, cells contained nicotinamide adenine dinucleotide-linked mannitol-1-phosphate dehydrogenase. Neither contained mannitol dehydrogenase. PMID- 4327614 TI - [Morphological and histochemical changes of the thyroid gland in disorders of steroid balance]. PMID- 4327615 TI - [Morphofunctional state of the thyroid gland in hypothermia and in the posthypothermic period]. PMID- 4327613 TI - Effects of citrate on the composition and metabolism of Lactobacillus casei. AB - Lactobacillus casei ATCC 393 converted small amounts of citrate to diacetyl, other volatile compounds, and lipids. Citrate was accumulated passively by the organism. The presence of citrate in the growth medium decreased the uptake of acetate and its conversion to cellular lipids. Cells grown in citrate media contained more protein per cell than did controls. This increased protein content was reflected mainly in the soluble fraction when cells were subjected to sonic lysis. Soluble fractions from cells cultured in the presence of citrate contained more total protein as well as more individual proteins than these fractions from control cells. The presence of citrate caused extensive flocculation and increased the susceptibility of cells to lysis. PMID- 4327616 TI - Primary carcinoma of the ovary. PMID- 4327617 TI - Tests of bacterial sensitivity to drugs. PMID- 4327618 TI - [Blood cortisol after inhibition and stimulation of persons with idiopathic hirsutism]. PMID- 4327619 TI - Brief aftercare on an inpatient ward. PMID- 4327620 TI - Urothelial micro-contour. II. Intracellular crypts and secretory substances. PMID- 4327621 TI - [Post-transfusional mononucleosic and cytomegalovirus syndrome. (Isolation of a cytomegalovirus in the blood of 3 patients)]. PMID- 4327622 TI - [Clinical aspects of the parasympathetic nervous system. Importance of recognition of different clinical conditions, in the eventual prevalence of the periferic parasympathical tonus and of its consequent influence on the circulatory system in the evaluation of the neurovegetative balance of the subject]. PMID- 4327623 TI - Radiation damage in calcium phosphates and collagen: an interpretation of ESR spectra. PMID- 4327624 TI - Effects of -irradiation on sodium sulphacetamide. PMID- 4327625 TI - The effect of prenatal -irradiation on postnatal enzyme development in the Beagle. PMID- 4327626 TI - [Humoral antibodies in rats under the influence of the non-carcinogenic analog of hepatotropic carcinogenic amino azo-compounds]. PMID- 4327627 TI - The human neutrophilic promyelocyte. A correlated phase and electron microscopic study. PMID- 4327628 TI - The cytology of the vitellogenic stages of oogenesis in Drosophila melanogaster. 3. Formation of the vitelline membrane. PMID- 4327629 TI - Nervous system of the snail Helix aspersa. II. Fine structure of vascular channels and amebocytes associated with the ganglionic sheath. PMID- 4327631 TI - [Glomera coronaria of the cat]. PMID- 4327630 TI - Ultrastructure of STH cells in the pars distalis of the hypophysis of mice bearing transplanted hepatomas. PMID- 4327632 TI - Investigations of the butylcholinesterase-containing cells of the adenohypophysis of the white-crowned sparrow, Zonotrichia leucophrys gambelii. PMID- 4327633 TI - Chronic ulcerative jejunoileitis. PMID- 4327634 TI - Steroid-induced diabetic ketoacidosis. PMID- 4327635 TI - 7S M-globulin in rheumatoid arthritis. Evaluation of its clinical significance. PMID- 4327636 TI - Glomerular cytoplasmic tubular structures in renal biopsies of patients with systemic lupus erythematosus and other diseases. PMID- 4327637 TI - [Results of surgical treatment of gastric carcinoma during the past 20 years]. PMID- 4327638 TI - [Therapy of peptic ulcer and its perspectives]. PMID- 4327640 TI - Recurring nasopharyngeal fibroma. PMID- 4327639 TI - Effect of streptozotocin on glucose-induced insulin secretion by isolated islets of Langerhans. PMID- 4327642 TI - [Information value of the activity of frog cerebellar cortex neurons and their interrelations]. PMID- 4327641 TI - [Oxygen tension and activity of respiratory enzymes in the skeletal muscles following administration of ACTH and hydrocortisone]. PMID- 4327643 TI - [Effect of vibrational stimulation of the gallbladder on the bioelectric activity of skeletal muscles]. PMID- 4327644 TI - Interception and retention of a simulated fallout by agricultural plants. PMID- 4327645 TI - Ultrastructural localisation of adrenal cholesterol by autoradiography and digitonin reaction after cycloheximide-induced inhibition of corticosterone synthesis. PMID- 4327646 TI - Mouse intestinal sensitivity to cycloheximide. A morphological, cytochemical and biochemical study. PMID- 4327647 TI - Pollen-wall proteins: localization, enzymic and antigenic activity during development in Gladiolus (iridaceae). PMID- 4327649 TI - The toxic effect of spermidine on normal and transformed cells. PMID- 4327648 TI - Segregation of morphological revertants in polyoma-transformed hybrid clones of hamster fibroblasts. PMID- 4327650 TI - A biochemical investigation into the inhibitory effects of glucosamine and N acetylclucosamine on the aggregation in vitro of embryonic chick muscle cells. PMID- 4327651 TI - Experimental pneumonia of sheep. Clinical, microbiological and pathological responses to infection with Myxovirus parainfluenzae 3 and Pasteurella haemolytica. PMID- 4327652 TI - Food and energy intake of rats fed diets varying in energy concentration and density. PMID- 4327653 TI - Influence of level of energy demand on the ability of rats to compensate for diet dilution. PMID- 4327654 TI - Renal transplantation, ruptured renal allograft and transplant lung. PMID- 4327655 TI - [Importance of catecholamines in internal medicine (I)]. PMID- 4327656 TI - [The effect of adrenalin and ACTH on glucose metabolism in the brain]. PMID- 4327657 TI - [The metabolism of phosphoinositide-protein complexes in the brain of growing and adult rats]. PMID- 4327658 TI - [Indications for excision of tumors in the iris and ciliary body]. PMID- 4327659 TI - [Leucocytic interferon and its combination with methacil for the therapy of viral diseases of the eye]. PMID- 4327660 TI - Chlorpromazine and human sleep. PMID- 4327661 TI - [Current state of surgery of the salivary glands. A critical review]. PMID- 4327662 TI - [Chronic amebiasis]. PMID- 4327664 TI - [Comparative study of the ultrastructure of cellular elements of some sections of reptilian and mammalian brains]. PMID- 4327663 TI - Peripheral neuropathy and central nervous system lesions in canine globoid-cell leukodystrophy (Krabbe's disease). PMID- 4327665 TI - [Physical and chemical characteristics and biosynthesis of myoalbumin of muscle tumors in rats]. PMID- 4327667 TI - [Change in the content of phosphorus compounds and glycogen in chicken tissue under the effect of vitamin D2 and D3]. PMID- 4327666 TI - [Effect of 4-methyluracil on enzymes of glycogen and glucose-6-phosphate metabolism in liver]. PMID- 4327668 TI - [Antirachitic milk substances]. PMID- 4327669 TI - [Age peculiarities in absorption of exogenous NAD by liver mitochondria in albino rats]. PMID- 4327670 TI - Fine structure of macrogametes and oocysts of Coccidia and related organisms. PMID- 4327673 TI - Enhanced interferon production in vitro by leucocytes from children with infectious mononucleosis. PMID- 4327671 TI - [The fine structure of the macrogamete of the mouse coccidium Eimeria falciformis]. PMID- 4327672 TI - Interferon producing capacity of white blood cells from patients with polyglobulia. PMID- 4327674 TI - Anti-complementary substances produced by KB cell cultures infected and not infected with virus. PMID- 4327675 TI - Clostridium perfringens related to roast beef cooking, storage, and contamination in a fast food service restaurant. PMID- 4327676 TI - Congenital epulis: its natural history. PMID- 4327677 TI - [Malignant tumors in otorhinolaryngology. II. Tumors of the nose and its sinuses. 1. Morbidity, symptomatology and diagnosis]. PMID- 4327678 TI - [Electric reaction of the frog taste cells in centrifugal stimulation]. PMID- 4327679 TI - Intermittent hormones. PMID- 4327680 TI - Glucagon. PMID- 4327681 TI - Mechanism of action of amantadine. PMID- 4327682 TI - Ultrastructural effects of estrogen on epiphyseal cartilage. PMID- 4327683 TI - [Differential diagnosis of malignant focal shadows in mammography]. PMID- 4327684 TI - A field program in the treatment of alcoholism. PMID- 4327685 TI - Aftercare for alcoholics discharged to distant communities. PMID- 4327687 TI - Plasma 17-ketosteroids and testosterone in prepubertal children before and after ACTH administration. PMID- 4327686 TI - Prolactin bioassay by induction of N-acetyllactosamine synthetase in mouse mammary gland explants. PMID- 4327688 TI - Altered biologic and immunologic activities of progressively desialylated human urinary FSH. PMID- 4327689 TI - Profile and possible origin of an adrenocortical carcinoma. PMID- 4327690 TI - Adrenocorticotropic potency of(1-glycine)-ACTH(1-18)-octadecapeptide amide in man. PMID- 4327691 TI - Effect of tolbutamide on adenyl cyclase in rabbit and human heart and contractility of isolated rabbit atria. PMID- 4327692 TI - Kleeblattschadel syndrome. PMID- 4327693 TI - Factors in cerebrospinal fluid from goats that affect sleep and activity in rats. AB - 1. Intraventricular infusion in the rat of 0.1 ml. cerebrospinal fluid (c.s.f.) from sleep-deprived goats increases the duration of sleep (measured by e.e.g.) and decreases locomotor activity (measured photo-electrically) for at least 6 hr subsequent to the infusion. Subarachnoid infusions are ineffective.2. C.s.f. from control and sleep-deprived goats was fractionated by ultrafiltration through molecular sieves. The sleep-promoting Factor S is found in the low molecular weight fraction (mol. wt. < 500) of c.s.f. from sleep-deprived but not from control goats.3. The concentration of Factor S in c.s.f. increases progressively during the first 48 hr of sleep deprivation.4. The sleep promoting effects of Factor S cannot be duplicated by serotonin, 4-OH-butyrate, butyrolactone, GABA (gamma-amino butyric acid), glutamic acid or 3',5'-cyclic AMP when these substances are added to control fluids in concentrations up to 10 times greater than those found in normal c.s.f.5. Intraventricular or subarchnoid infusion in the rat of 0.1 ml. proteinfree c.s.f. containing molecules in the mol. wt. range of 500-10,000 at 10-30 x normal concentration causes hyperactivity which persists for several days and nights following the infusion. The excitatory material, probably a peptide, is present in c.s.f. from both control and sleep-deprived goats.6. The properties of Factor S suggest that it may play a role in the normal regulation of sleep and wakefulness. PMID- 4327695 TI - Effect of sulfhydryl reagents on phenolase action. PMID- 4327696 TI - Effects of o-phenanthroline and rotenone on the energy-linked swelling of rat liver mitochondria. PMID- 4327697 TI - [Comparative results of plasmatic renin determination and the angiotensin perfusion test in arterial hypertension]. PMID- 4327694 TI - The effect of temperature change upon transmitter release, facilitation and post tetanic potentiation. AB - 1. End-plate potentials (e.p.p.s) and miniature end-plate potentials (m.e.p.p.s) were intracellularly recorded from rat diaphragm phrenic nerve preparations in vitro at temperatures between 7 degrees and 40 degrees C.2. The quantal content of e.p.p.s and the frequency of m.e.p.p.s showed broadly similar relationships with temperature, with maxima about 20 degrees and above 39 degrees C.3. Analysis of the change in e.p.p. quantal content showed that the maximum about 20 degrees C was accompanied by a similar maximum of p, the probability of release of quanta. The maximum above 39 degrees C was associated with a rise in n, a presynaptic store of material needed for release.4. The rate at which transmitter could be mobilized was linear in an Arrhenius plot with an apparent activation energy of 25 kcal deg(-1).5. Facilitation and post-tetanic potentiation (PTP) were shown to be entirely attributable to changes in p.6. It is suggested that facilitation and PTP have a common basis and that the (temperature-dependent) rate of Ca removal from intracellular sites at which it exerts its action is as important a determinant of the magnitude of quantal release as is the amount of Ca combining with these sites. PMID- 4327699 TI - [Pituitary function test using synthetic lysine-8-vasopressin--comparison with metopirone test and insulin stress test]. PMID- 4327698 TI - [Determination of hormones by radioimmunoassay including thyroid hormones and steroids]. PMID- 4327700 TI - [Morphology and function of pituitary cells]. PMID- 4327701 TI - [Recent findings on the Cushing's syndrome]. PMID- 4327702 TI - [Mechanism of action of hormones with special reference to recent progress in cyclic AMP theory]. PMID- 4327703 TI - [Recent topics on sex hormones]. PMID- 4327705 TI - Membrane phosphatase and active transport of cations. PMID- 4327704 TI - [Round table conference: current topics in endocrinology]. PMID- 4327706 TI - Antiviral agents. PMID- 4327707 TI - Reserpine and sleep. PMID- 4327708 TI - [Indications and prospects of endolymphatic radioisotope therapy]. PMID- 4327709 TI - Concurrent pulmonary tuberculosis and primary carcinoma. PMID- 4327710 TI - Complications of mediastinal neural tumours. PMID- 4327712 TI - [Micro-epidemices of leukemia?]. PMID- 4327711 TI - Independent bilateral primary bronchial carcinomas. PMID- 4327713 TI - Inhibition of interferon synthesis in phospholipase C treated primary chick embryo cells. PMID- 4327714 TI - Comparison of polysomal structures of uninfected and poliovirus infected HeLa cells. PMID- 4327715 TI - In vitro protein synthetic activity of membrane-bound poliovirus polyribosomes. PMID- 4327716 TI - Viral interference in feline leukemia-sarcoma complex. PMID- 4327717 TI - On the structure of rhinovirus 1A. PMID- 4327718 TI - Some structural properties of the DNA molecule from bacteriophage alpha. PMID- 4327719 TI - The association of pinwheel inclusions with plasmodesmata. PMID- 4327720 TI - DNA polymerase in defective Rous sarcoma virus. PMID- 4327721 TI - [Changing effect of gastroenteron and kidney function from the clinical view]. PMID- 4327723 TI - Functional properties of the ventrolateral thalamic nucleus during natural sleep and wakefulness. PMID- 4327722 TI - [Physiology of the thalamus]. PMID- 4327724 TI - Short-term acute psychiatric care: a follow-up study. PMID- 4327726 TI - [Formation of free radicals in constituents of DNA photosensitized by proflavine]. PMID- 4327728 TI - [Therapy of Ps. pyocyanea meningitis]. PMID- 4327727 TI - Interaction of ADP-ribosylated aminoacyl-transferase II with GTP and with ribosomes. PMID- 4327725 TI - Diethyl pyrocarbonate, a new tool in the chemical modification of nucleic acids? PMID- 4327729 TI - Effect of CRF on the morphological and functional differentiation of the cultured chromophobes isolated from rat anterior pituitaries. PMID- 4327730 TI - Structure-activity relationships of synthetic adrenocorticotropic octadecapeptides with special reference to biological half-life. PMID- 4327731 TI - Effect of ACTH on turnover of phospholipids in rat adrenal glands. PMID- 4327732 TI - [Content of nucleic acids (RNA and DNA) in the brain and liver after adrenalectomy and application of ACTH]. PMID- 4327733 TI - [The renin-angiotensin-aldosterone system under the influence of drugs]. PMID- 4327734 TI - Demonstration of endocytosis vesicles by means of electron-microscopic histochemistry. PMID- 4327735 TI - The effect of adenosine 3',5'-monophosphate on ( 3 H)thymidine incorporation in vitro into mouse spleen and thymic cells. PMID- 4327736 TI - Transfer of metabolites across the nuclear membrane. A microfluorometric study. PMID- 4327737 TI - Destruction of free radicals by radiation. PMID- 4327738 TI - Molecular size of simian virus 40-specific RNA synthesized in productively infected cells. PMID- 4327739 TI - Effects of 5-HTP on sleep in Mongol children. Preliminary results. PMID- 4327740 TI - Circulating glucose and insulin in surgery for insulomas. PMID- 4327741 TI - Metabolic interaction of ethanol and sorbitol in relation to redox state of liver cytosol in hypo-, hyper-, and euthyroid rats. PMID- 4327742 TI - Effect of prostaglandins on guinea pig myocardial adenyl cyclase. PMID- 4327743 TI - Single dose dexamethasone in treatment of congenital adrenocortical hyperplasia. PMID- 4327744 TI - Enzymatic detachment of endplate acetylcholinesterase from muscle. PMID- 4327745 TI - Cyclic AMP, transmitter release and the effect of adenosine on neuromuscular transmission. PMID- 4327746 TI - Spontaneous remission of proven cancer. PMID- 4327747 TI - [Plasma adrenocorticotropic activity in Itsenko-Cushing disease]. PMID- 4327748 TI - [Effect of chorionic gonadotropin on plasma corticosterone levels in the rat]. PMID- 4327749 TI - [Some current problems in viral respiratory infections]. PMID- 4327750 TI - [Aspects of viremia in some enteroviral infections]. PMID- 4327751 TI - [Epidemiological considerations on the incidence of adenovirus antibodies in the population between 1965 and 1970]. PMID- 4327752 TI - Degradation of the side-chain of cortisol by lens homogenate. PMID- 4327753 TI - On modelling neural networks in the retina. PMID- 4327754 TI - Ultrastructure of mesangial and juxtaglomerular cells in the kidney of a hibernator. PMID- 4327755 TI - Water and solute transport by the Malpighian tubules of the stick insect, Carausius morosus. The normal ultrastructure of the type 1 cells. PMID- 4327756 TI - [Light and electron microscopic studies on the cerebral gland of Polyxenus lagurus (L.) (Diplopoda, Penicillata)]. PMID- 4327757 TI - [ACTH secretion by extra-pituitary tumors]. PMID- 4327758 TI - [Therapy and follow-up results of luxations of the os lunatum]. PMID- 4327759 TI - [Calcification in bone formation]. PMID- 4327760 TI - Slow wave sleep deprivation in relation to plasma growth hormone concentration. PMID- 4327762 TI - The effect of noradrenaline on the incorporation of 32 P into brain phospholipids. PMID- 4327761 TI - Studies on lysosomes. 13. Effects of stilbamidine and hydroxystilbamidine on in vitro and in vivo systems. PMID- 4327763 TI - Studies on the mechanism of resistance to alkylating agents of three ascites tumours in the rat. PMID- 4327765 TI - 16-oxygenation of 17 -methyltestosterone in rabbits. PMID- 4327767 TI - Studies of schistosomicides antimonials on isolated mitochondria. I. Sodium antimony gluconate (Triostib). PMID- 4327764 TI - Inhibition of mitochondrial oxidation and uncoupling of phosphorylation by antispermatogenic bis-dichloroacetamides. PMID- 4327766 TI - Some aspects of the mechanism of action of 1-propyl-1-nitrosourea. PMID- 4327768 TI - Diethyl stilbestrol--mode of inhibition of the (Na + +K + )-dependent adenosine triphosphatase. PMID- 4327769 TI - Influence of ethanol and butyraldoxime on liver metabolism. PMID- 4327771 TI - [Cryotherapy of herpetic keratitis; its results]. PMID- 4327772 TI - [Severe myopia: treatment]. PMID- 4327770 TI - Diethyl chelidonate, a specific inhibitor of hormone-stimulated lipolysis. PMID- 4327773 TI - Magendie on medicine. PMID- 4327774 TI - Ductal carcinoma involving the lobule of the breast. A source of confusion with lobular carcinoma in situ. PMID- 4327775 TI - 45Ca uptake during the in vitro release of hormones from the rat adenohypophysis. PMID- 4327776 TI - Role of adenosine-3',5'-monophosphate in the hormonal regulation of bone resorption: studies with cultured fetal bone. PMID- 4327777 TI - Effects of streptozotocin on carbohydrate and lipid metabolism in the rat. PMID- 4327778 TI - Role of inorganic pyrophosphatase in the mechanism of action of parathyroid hormone and calcitonin. PMID- 4327779 TI - In vivo effects of intercalating drugs on the superhelix density of mitochondrial DNA isolated from human and mouse cells in culture. PMID- 4327780 TI - C-cell thyroid adenoma in man. PMID- 4327781 TI - Experimental chronic interstitial nephritis compared with endemic human nephropathy. PMID- 4327782 TI - The role of cancer cell protease in invasion of rat ascites hepatome AH 109 A cells, with special reference to pulmonary metastasis of subcutaneously transplanted cells. PMID- 4327783 TI - [Intrathoracic neurogenic tumors (report of 4 cases)]. PMID- 4327784 TI - [Involvement of the nervous system in the course of rheumatoid arthritis]. PMID- 4327785 TI - [Tissue collagenases]. PMID- 4327786 TI - [Mechanism of action of insulin]. PMID- 4327787 TI - [Mechanism of insulin secretion with special regard to prediabetes]. PMID- 4327788 TI - [Sleep in parkinsonism]. PMID- 4327789 TI - Progressive dementia caused by an unusual type of generalized small vessel thrombosis. PMID- 4327790 TI - [Case of vitamin D dependency--influence of VD3 on calcium absorption of the intestine]. PMID- 4327791 TI - [In vitro cytotoxic effects of antineoplastic agents on malignant tumor cells derived from children]. PMID- 4327792 TI - Cardiac myofibrillar ATPase: a comparison with that of fast skeletal actomyosin in its native and in an altered conformation. PMID- 4327793 TI - A rapid procedure for the isolation of rat liver mitochondria. PMID- 4327794 TI - [Oxido-reduction reactions at the level of cytoplasmic membranes and mesosomes of Bacillus subtilis]. PMID- 4327795 TI - Isolation and properties of rubredoxin from the photosynthetic green sulfur bacteria. PMID- 4327797 TI - Electron transport activities in rat liver endoplasmic reticulum membrane fragments prepared by chromatography on Sepharose 2B. PMID- 4327798 TI - [Intracranial expansive processes in African children]. PMID- 4327796 TI - Photorespiration during C 4 photosynthesis. PMID- 4327799 TI - [Retrospective study of 175 cancers in children observed at the Hopital Le Dantec]. PMID- 4327800 TI - [The glomus jugulare and its tumors]. PMID- 4327801 TI - [Round-table discussion on viral hepatitis]. PMID- 4327802 TI - Herpes simplex keratitis: the effect of antilymphocyte serum and normal horse serum on viral proliferation and bacterial flora. PMID- 4327803 TI - [Total protein content and quantity of basic proteins in neurons and neuroglia of rat brain supraoptic and red nuclei during natural sleep and deprivation of paradoxical sleep]. PMID- 4327804 TI - The art and gentle science of Pisse-Prophecy. PMID- 4327805 TI - [Antitubercular agents]. PMID- 4327806 TI - Addison's disease. A review of thirty-two cases. PMID- 4327807 TI - The effects of -methyltyrosine on sleep and brain norepinephrine in cats. PMID- 4327808 TI - Mechanism of antilipolytic effects of cardiac glycosides. PMID- 4327809 TI - Characterization of a dipeptide hydrolase (kininase II: angiotensin I converting enzyme). PMID- 4327810 TI - Ganglionic stimulation: mechanism of the positive inotropic and chronotropic effects of angiotensin. PMID- 4327811 TI - The relative effect of the renal pressor and sympathetic nervous systems on vascular capacity during hypotension. PMID- 4327812 TI - Current concepts in minimal brain dysfunction. PMID- 4327813 TI - Cyclophosphates. IV. Penetration studies with A-3': 5'-MP in the rat liver. PMID- 4327814 TI - Auxin-induced synthesis of cyclic 3', 5'-adenosine monophosphate in Avena coleoptiles. PMID- 4327815 TI - Stimulation of erythropoiesis by cyclic adenosine monophosphate. PMID- 4327816 TI - [75 cases of plantar mal perforant]. PMID- 4327817 TI - [Hypothalamo-pituitary-adrenal function in asthmatics after prolonged treatment with corticosteroids or Synacten-depot]. PMID- 4327818 TI - [Para-influenza infection]. PMID- 4327819 TI - [Clinical and pharmacologic studies of synthetic ACTH]. PMID- 4327820 TI - [Synthetic human corticotropin (alpha-h ACTH) and bacterial phagocytosis of leukocytes]. PMID- 4327821 TI - [Action of the pyridoxine-hydroxocobalamin combination in high doses in peripheral neuropathies]. PMID- 4327822 TI - Adrenotrophic action of ACTH in thyroidectomized rats. PMID- 4327823 TI - Anatomo-clinical study of the adrenals in nephrosclerosis. PMID- 4327824 TI - [Orthostatic hypotension following cyclazenine medication]. PMID- 4327825 TI - [Indications and limitations of infusion cholecystocholangiography]. PMID- 4327826 TI - [Antibiotic 6431-36 showing antiviral and antibacterial effect]. PMID- 4327827 TI - Perspectives in aldosterone and renin control. PMID- 4327828 TI - [Cytophotometric study of precancerous lesions of the female breast]. PMID- 4327829 TI - [Influence of hydrolysing time on chemical demonstrability of DNA and RNA in tissue homogenates]. PMID- 4327831 TI - [Identification of foot-and-mouth disease virus types]. PMID- 4327832 TI - [Identification of foot-and-mouth disease virus types]. PMID- 4327830 TI - [Incidence of vesicular diseases in Colombia in 1970]. PMID- 4327833 TI - [Serologic and immunologic studies of the subtypes of foot-and-mouth disease virus. Influence of booster vaccination]. PMID- 4327834 TI - Treatment of drug-resistant tuberculosis. PMID- 4327836 TI - Effect of pentylenetetrazol on the leech retzius cell. PMID- 4327835 TI - Effect of dithionite on enzyme activities in vivo. PMID- 4327837 TI - A trigeminal monosynaptic reflex in reptillia. PMID- 4327838 TI - Histochemical analysis of hyperplastic lesions and hepatomas of the liver of rats fed 2-fluorenylacetamide. PMID- 4327839 TI - Responsiveness of hyperplastic lesions and hepatomas to partial hepatectomy. PMID- 4327840 TI - [Peripheral nerve lesions: relation between clinical and electromygraphic data]. PMID- 4327841 TI - From salted onions to clorox and milk. PMID- 4327842 TI - Sexual activity and cervical carcinoma. PMID- 4327843 TI - [Role of viruses in otorhinolaryngological diseases]. PMID- 4327844 TI - [Course and prognosis of infantile epilepsy in relation to present-day treatment]. PMID- 4327845 TI - Renal concentrating ability in mice: a model for the use of genetic variation in elucidating relationships between structure. PMID- 4327846 TI - Roentgenographic demonstration of intrapulmonary and pleural lymphatics during lymphangiography. PMID- 4327847 TI - Cholangiocarcinoma. PMID- 4327848 TI - Pulmonary and extrapulmonary fate of angiotensin I. PMID- 4327849 TI - The role of the kidneys and adrenal glands in the blood pressure response to hemorrhage. PMID- 4327851 TI - [A decrease in vesicular stomatitis virus plaque size in the presence of diethylaminoethyldextran (DEAED) and isolation of a mutant resistant to DEAED]. PMID- 4327852 TI - [Anomalies in the primary structure of the DNA of phages of the DD-series associated with glucosidation]. PMID- 4327850 TI - [Chronic viral infection in transplantable cultures of human leukemia (J-96) and mouse fibroblast (L) cells, produced by inoculation of the cultures with Coxsackie B5 and vesicular stomatitis viruses in the presence of antisera to the infected cells]. PMID- 4327853 TI - [The effect of polyoma virus on cell proliferation in vitro]. PMID- 4327854 TI - [Formation of antiviral antibodies by spleen cells stimulated by an antigen in vitro, after transplantation to newborn and irradiated recipients]. PMID- 4327855 TI - [The associative interrelationships of Mycoplasma pneumoniae and respiratory syncytial virus in cell cultures]. PMID- 4327857 TI - [The temperature sensitive mutants of poliovirus. I. Acquisition and characteristics of the mutants]. PMID- 4327856 TI - [Mouse sarcoma virus]. PMID- 4327858 TI - [Detection of cellular antigens in myxoviruses and paramyxoviruses by the immunodiffusion method]. PMID- 4327859 TI - [Characteristics of Sendai virus RNA when studies in polyacrylamide gels]. PMID- 4327860 TI - [The role of various picornaviruses in the etiology of intestinal dyspepsia]. PMID- 4327861 TI - [A comparative study of Rous virus variants isolated from murine Rous sarcoma and the original Carr-Zilber strain]. PMID- 4327862 TI - [Characterization of cholinergic drugs with regard to their receptor properties]. PMID- 4327863 TI - [Study of paradoxical sleep]. PMID- 4327864 TI - Tick feeding and its implications. PMID- 4327866 TI - Benignity of neonatal tumors and concept of cancer repression in early life. PMID- 4327865 TI - The relationship between circulating antibodies and immunity to helminthic infections. PMID- 4327867 TI - Imipramine pamoate in the treatment of childhood enuresis. A double-blind study. PMID- 4327869 TI - Activity of some enzymes in Physarum polycephalum. 3. During spherulation (differentiation) induced by mannitol. PMID- 4327868 TI - Differential release of periplasmic versus cytoplasmic enzymes from Escherichia coli B by polymixin B. PMID- 4327870 TI - Bluetongue virus: some relationships among North American isolates and further comparisons with EHD virus. AB - Seven isolates of bluetongue virus with different isolation histories and one isolate of the virus of epizootic hemorrhagic disease of deer were cloned by three consecutive plaquings in L-929 cells. The isolates were categorized on plaque size and margin. Antisera to the bluetongue virus isolates were produced in calves and antiserum to epizootic hemorrhagic disease virus in deer. Plaque reduction neutralization tests were done using the eight isolates and antisera to six of these. The isolates could be partially categorized on plaque type. In the plaque reduction neutralization test, all of the bluetongue viruses cross reacted and although differences were frequently observed, no obvious antigenic classification was possible. Reactions between the bluetongue viruses and epizootic hemorrhagic disease virus were all within the limits of what is presently considered to be non-specific inhibition. PMID- 4327871 TI - Inhibition of ACTH release by a central inhibitory mechanism in the basal forebrain. PMID- 4327872 TI - Hormonal regulation of cyclic 3',5'-AMP in specific recetor tissues. Biological effects of a synthetic N-terminal tetratriacontapeptide of parathyroid hormone. PMID- 4327874 TI - Mode of action of dibutyryl cyclic AMP on bone. PMID- 4327873 TI - A parathyroid hormone-like action of dibutyryl cyclic AMP (DCA) on explanted embryonic mouse radius. II. The effect of DCA and parathyroid hormone on the linear growth of the radius. PMID- 4327875 TI - Acid pyrophosphatase, phosphoproteinphosphatase and phosphomonoesterase activities in bone tissue. PMID- 4327876 TI - Characterization of aminopeptidases and phosphatases of human fetal periosteum. PMID- 4327877 TI - Effect of cortisone on vitamin D metabolism. PMID- 4327878 TI - Vitamin D metabolism in experimental uremia. PMID- 4327879 TI - Leukocidin, tetraethylammonium ions, and the membrane acyl phosphatases in relation to the leukocyte potassium pump. AB - The response of the leukocyte to leukocidin and its relevance to excitable and secreting tissues are described. New data are presented on the leukocyte membrane phosphatases and the action of tetraethylammonium ion (TEA) on the leukocyte. The leukocyte surface membrane lacks a cation-sensitive ATPase but possesses a potassium- and ouabain-sensitive p-nitrophenyl phosphatase. The p-nitrophenyl phosphatase shows peak activity at three pH values and the pH dependence and potassium sensitivity depend on the state of the membranes. In the presence of magnesium, potassium can stimulate over the range pH 6 to 8. The relation of the leukocyte p-nitrophenyl phosphatase to electrolyte control in the leukocyte and to the properties of cation-sensitive phosphatases in other cells suggests that the leukocyte enzyme is a component of an electrogenic potassium pump. Leukocidin stimulates the leukocyte p-nitrophenyl phosphatase under all the conditions studied. The effect is specific and occurs under conditions that induce cytotoxic effects in the cell. It is concluded that the potassium pump is the site of action of leukocidin. TEA prevents the effects of leukocidin by inhibiting the action of leukocidin and not the responses of the cell to injury. TEA does not inhibit the p-nitrophenyl phosphatase nor prevent its stimulation by leukocidin. The enhancement of leukocidin by diisopropylphosphofluoridate (DFP) is briefly described. It is concluded that TEA acts in the opposite way to DFP and blocks the ion pathway activated by leukocidin in the leukocyte potassium pump. PMID- 4327882 TI - Simplified method for radioimmunoassay of enzyme systems. Application on the human renin-angiotensin system. PMID- 4327880 TI - Desensitization of gamma aminobutyric acid (GABA) receptors in muscle fibers of the crab Cancer borealis. AB - Carcinus muscle fibers respond to gamma-aminobutyric acid (GABA) with a conductance increase that subsides rather rapidly. In the larger fibers which have low input resistance the decrease may disappear within 2 min. The inhibition of the excitatory postsynaptic potentials (EPSP's) by GABA nevertheless persists as long as the drug is applied. The subsidence of the increased conductance indicates that the membrane of the inhibitory synapses has become desensitized to GABA. The persistence of inhibition of the EPSP's appears to be due to an action of the drug on the presynaptic terminals of the excitatory axons which reduces or blocks the secretory activity that releases the excitatory transmitter. PMID- 4327881 TI - Inorganic pyrophosphate concentrations in the synovial fluid of arthritic patients. PMID- 4327883 TI - The fine structure of canine gliomas and intracranial sarcomas induced by the Schmidt-Ruppin strain of the Rous sarcoma virus. PMID- 4327884 TI - Cytoplasmic inclusions in Chediak-Higashi and Wobbler mink. An electron microscopic study of the nervous system. PMID- 4327885 TI - Vincristine-induced axonal alterations in rat peripheral nerve. PMID- 4327886 TI - The subarachnoid space following the introduction of a foreign protein: an electron microscopic study with peroxidase. PMID- 4327888 TI - Separation and quantitative assay of furazolidone and nifuroxime in suppositories by magnesium silicate adsorption column chromatography. PMID- 4327887 TI - Mechanism of action of starch as a tablet disintegrant IV: effect of medicaments and disintegrants on mean pore diameter and porosity. PMID- 4327889 TI - [Control of thermogenesis in adipose brown tissue]. PMID- 4327890 TI - Proteins of polyhedal cytoplasmic deoxyvirus. II. Nucleotide phosphohydrolase activity associated with frog virus 3. AB - A nucleotide phosphohydrolase is firmly associated with a purified polyhedral cytoplasmic deoxyvirus, frog virus 3. This adenosine triphosphatase is distinguishable from known mammalian cell adenosine triphosphatases and from adenosine triphosphatase of an unrelated cytoplasmic replicating virus grown in the same host cell. The enzyme activity has a high specificity for adenosine triphosphate; the product of the reaction is adenosine diphosphate. The presence of similar activities in reovirus and poxvirus indicates that adenosine triphosphatase might have a function in the replication of these viruses. PMID- 4327891 TI - Comparison of the ribonucleic acid polymerases of two rhabdoviruses, Kern Canyon virus and vesicular stomatitis virus. AB - A ribonucleic acid (RNA)-dependent RNA polymerase has been demonstrated in Kern Canyon virus (KCV) particles. The RNA product of the KCV polymerase hybridizes to KCV viral RNA. The properties of this viral enzyme have been characterized and compared with those of vesicular stomatitis virus (VSV). RNA polymerases from both viruses require similar conditions of temperature, pH, and detergent and magnesium concentrations for maximal synthesis of RNA. The RNA polymerase contained in the virion of KCV was more dependent on the presence of a sulfhydryl agent than was the VSV enzyme. Under optimal conditions, the specific activity of the VSV polymerase is about twenty-five times as great as that of KCV. PMID- 4327892 TI - Quantitative studies of pseudorabies virus in mink, ferrets, rabbits and mice. PMID- 4327893 TI - [Bilateral study on renal elimination of urea, electrolytes and glucose in asymmetric pyelonephritis]. PMID- 4327895 TI - [Radioimmunologic determination of angiotensin 2. Study on healthy individuals and on patients with congestive heart failure]. PMID- 4327894 TI - [Determination of plasma renin activity by radioimmunoassay of angiotensin 1. Comparison with bioassay]. PMID- 4327896 TI - [Effect of cultivation conditions on the growth and pigment formation of Actinomyces rectiviolaceus]. PMID- 4327897 TI - [Free amino acids in the cells of Bacillus polymyxa var. Ross]. PMID- 4327898 TI - [Effect of phosphorus metabolism in Proactinomyces fructiferi var. ristomycini on the biosynthesis of ristomycin]. PMID- 4327900 TI - [Invasion of the intestinal wall and hypersensitivity to Entamoeba histolytica]. PMID- 4327899 TI - [Synacthen-depot in inflammatory diseases of the central nervous system. Clinical studies]. PMID- 4327901 TI - Odontogenic tumours in polyoma virus-infected mice. PMID- 4327902 TI - Collagenase and oral disease. PMID- 4327903 TI - Viruses and the salivary glands. PMID- 4327904 TI - [Immunoreaction of lipids--a step in the study of the membrane structure]. PMID- 4327905 TI - Contraction of chicken rectum to nerve stimulation after blockade of sympathetic and parasympathetic transmission. PMID- 4327906 TI - [The work of Andre Leri]. PMID- 4327907 TI - [Hepatoma and liver cirrhosis in children--case reports and review of the literature]. PMID- 4327909 TI - A selective differential medium for histotoxic Clostridia. PMID- 4327910 TI - Reaction of reduced nicotinamide adenine dinucleotide with 2,4 dinitrophenylhydrazine in serum lactate dehydrogenase assays. PMID- 4327908 TI - [The role of various endocrine glands in the pathogenesis of hormone-active tumors of the adrenal cortex]. PMID- 4327911 TI - Anomalous serum protein in hepatocarcinoma and hepatic metastases. PMID- 4327912 TI - The role of lysosomes in the pathogenesis of experimental viral hepatitis. PMID- 4327913 TI - Isolation of a new parainfluenza virus from a frugivorous bat, Rousettus leschenaulti, collected at Poona, India. PMID- 4327914 TI - Bat parainfluenza virus. Immunological, chemical, and physical properties. PMID- 4327916 TI - Rate of destruction of Schistosoma mansoni eggs in the tissues of mice. PMID- 4327915 TI - Babesia species isolated from a woman with clinical babesiosis. PMID- 4327917 TI - [Effect of rifampicin on the reproduction of DNA containing viruses in tissue culture cells]. PMID- 4327919 TI - Hepatitis immunity. PMID- 4327918 TI - [Experimental study of the most rational combinations of rifocin with different antibiotics in relation to inducers of surgical infection]. PMID- 4327921 TI - [Concepts of excitation and inhibition in the physiology of the higher nervous centers]. PMID- 4327920 TI - Prevention of delayed traumatic facial palsy. AB - A previous impression that corticotrophin provided prophylaxis against delayed traumatic facial palsy has now been confirmed by the results obtained from the first 50 patients so treated. PMID- 4327922 TI - [Neuronal circuits of the cerebral cortex]. PMID- 4327924 TI - [Viral diseases of the oral cavity in children and their treatment]. PMID- 4327923 TI - Effects of placebo and flurazepam on sleep patterns in insomniac subjects. PMID- 4327925 TI - Cytomegalovirus mononucleosis. PMID- 4327926 TI - [Chromatin movement during nuclear secretion in the seminiferous gland of the green crab and evolutionary significance of this phenomenon]. PMID- 4327927 TI - [Isolation of nuclei from the myocardium and skeletal muscles and their enzymatic characteristics]. PMID- 4327928 TI - [Radiculography using emulsified Duroliopaque]. PMID- 4327929 TI - [New uses of water-soluble contrast media in neuroradiology]. PMID- 4327930 TI - Brain lipids of mice homozygous for the gene 'dilute lethal' (d). PMID- 4327932 TI - Fractionation of goldfish brain aminoacyl-transfer RNA at the microgram level. PMID- 4327931 TI - The response of human cerebrum adenyl cyclase to biogenic amines. PMID- 4327933 TI - Metabolites of ( 3 H)acetate bound to synaptic vesicles isolated from rat cerebral cortex. PMID- 4327934 TI - Liver tumours in infancy and childhood. PMID- 4327935 TI - Granular-cell myoblastoma of the bronchus. PMID- 4327936 TI - I-cell disease: a clinical picture. PMID- 4327937 TI - Clinical, biochemical, and ultrastructural studies in a case of chondrodystrophy presenting the I-cell phenotype in tissue culture. PMID- 4327938 TI - Disseminated herpesvirus infection in a newborn infant. Virologic, serologic, coagulation, and interferon studies. PMID- 4327939 TI - Placental cytomegalovirus infection without fetal involvement following primary infection in pregnancy. PMID- 4327941 TI - Management of cardiac arrest. PMID- 4327940 TI - The half-hour synthetic 1-24 corticotropin test of adrenocortical reserve in children. PMID- 4327943 TI - [Hypothesis on the mechanism of search and facilitation of pathways in a neuron net]. PMID- 4327942 TI - The role of cyclic AMP in the immunocompetent cell. PMID- 4327944 TI - [Benign tumors of the stomach]. PMID- 4327945 TI - [Histological and histochemical studies of the islands of Langerhans of the swine pancreas (Sus scrofa)]. PMID- 4327946 TI - Ultrastructure of the esophageal region in Schistosoma mansoni. PMID- 4327947 TI - Etiologic study of diarrheal disease in Vietnam. PMID- 4327948 TI - Evaluation of new neuromuscular blocking agents. PMID- 4327949 TI - The management of the presuicidal, suicidal, and postsuicidal patient. PMID- 4327950 TI - Streptozotocin for insulinoma. PMID- 4327951 TI - [Differential diagnosis of the occupational diseases bursitis (22), nerve compression injuries (23), paratendinoses (43), vertebral process fractures (45)]. PMID- 4327952 TI - The physiology of dreaming. PMID- 4327953 TI - Phosphorylation of rat liver ribosomal subunits: partial purification of two cyclic AMP activated protein kinases. PMID- 4327954 TI - Polyphosphoinositide levels and biosynthesis in quaking mouse brain. PMID- 4327955 TI - Requirement of cyclic AMP for induction of GMP reductase in Escherichia coli. PMID- 4327956 TI - Hormonal effects on the neural retina: induction of glutamine synthetase by cyclic-3',5'-AMP. PMID- 4327958 TI - Carbon-13 pulse Fourier transform N. M. R. of lecithins. PMID- 4327957 TI - Inhibition of transketolase by analogues of the coenzyme. PMID- 4327959 TI - Adrenal medullary stimulation induced by angiotensin I, angiotensin II, and analogues. PMID- 4327960 TI - 18-Hydroxy-deoxycorticosterone in human hypertension. PMID- 4327961 TI - Determination of plasma renin concentration by angiotensin I immunoassay. Diagnotic import of precise measurement of subnormal renin in hyperaldosteronism. PMID- 4327963 TI - [Cholangiodysplastic, cystic pseudocirrhosis and its importance for the differential diagnosis of liver cirrhosis]. PMID- 4327962 TI - Effects of angiotensin infusion on catecholamine uptake and reactivity in blood vessels. PMID- 4327964 TI - Sleep patterns in depression. Longitudinal study of six patients and brief review of literature. PMID- 4327965 TI - Fine structure of oogonial and oocyte development in Dermacentor andersoni Stiles (Acari: Ixodidae). PMID- 4327967 TI - A comparison of genome sizes and thermal-denaturation-derived base composition of DNAs from several members of Entamoeba (histolytica group). PMID- 4327966 TI - Characterization of the deoxyribonucleic acid of representative strains of Entamoeba histolytica, E. histoytica-like amebae, and E. moshkovskii. PMID- 4327968 TI - The value of plasma corticosteroid assays in the diagnosis of Cushing's disease in the dog. PMID- 4327969 TI - The fine structure of the lateral nasal gland (Steno's gland) of the rat. PMID- 4327970 TI - Permeability of the epidermis and the phagocytic activity of keratinocytes. Ultrastructural studies with thorotrast as a marker. PMID- 4327972 TI - Demonostration of the intercellular spaces of the human eccrine sweat gland by lanthanum. I. The secretory coil. PMID- 4327971 TI - Atypical cristae in mitochondria of human glioblastoma multiforme cells. PMID- 4327973 TI - [Effect of anesthesia and surgical trauma on the functional state of the adrenal cortex in patients treated with steroid hormones]. PMID- 4327974 TI - [Mechanism of the diuretic effect of cardiac glycosides]. PMID- 4327976 TI - [Changes in the activity of rat liver fructose-1,6-diphosphatase during gestation]. PMID- 4327975 TI - [Effect of adenosine-3,'5'-cyclic monophosphate on basal gastric acid secretion in human]. PMID- 4327977 TI - [Effect of uremia on the drug-catalolizing enzymes in rat liver microsomes]. PMID- 4327978 TI - Concentration and synthesis of phosphoribosylpyrophosphate in erythrocytes from normal, hyperuricemic, and gouty subjects. PMID- 4327979 TI - Cyclic nucleotide phosphodiesterase activity in man, monkey, and rat. PMID- 4327980 TI - Effect of theophylline on glucagon and glucose-mediated plasma insulin responses in subhuman primate fetus and neonate. PMID- 4327981 TI - The afferent impulse traffic from atrial A-type receptors in cats. Does the A type receptor signal heart rate? PMID- 4327982 TI - [Analysis of oligosaccharides. 2]. PMID- 4327983 TI - Effect of hypoxia on carotid chemoreceptor response to carbon dioxide in cats. PMID- 4327984 TI - Neurologic and psychopathologic aspects of compulsive crying and laughter in pseudo-bulbar palsy patients. PMID- 4327985 TI - [Double peritoneal dissemination of hydatidosis and concomitant hepatocellular carcinoma]. PMID- 4327986 TI - [Adenoid cystic carcinoma of the male breast]. PMID- 4327987 TI - [Benign non-epithelial gastric tumors derived from elements of the stomach itself. Review of the literature and personal anatomo-clinical cases]. PMID- 4327988 TI - [Undirected liver biopsy in children]. PMID- 4327989 TI - Stimulation-dependent alterations in peroxidase uptake at lobster neuromuscular junctions. AB - The uptake of cytochemically demonstrable horseradish peroxidase into small vesicles within nerve endings in lobster stretcher muscles can be enhanced by electrical stimulation of transmitter release by the endings. This is observed particularly if stimulation is interrupted periodically and the nerves PMID- 4327990 TI - Cyclic 3',5'-nucleotide phosphodiesterase: cytochemical localization in cerebral cortex. AB - The distribution of cyclic 3',5'-nucleotide phosphodiesterase activity in rat cerebral cortex was determined by cytochemical methods. The detectable phosphodiesterase activity was localized in postsynaptic (dendritic) nerve endings, most of it immediately adjacent to the synaptic membrane. Most of the postsynaptic nerve endings showed phosphodiesterase activity. PMID- 4327991 TI - Effect of operation upon sodium metabolism and aldosterone secretion rate in children. PMID- 4327992 TI - Unlicensed medical practice in West Malaysia. PMID- 4327993 TI - The fine structure of the central synaptic contacts on an identified Crustacean motoneuron. PMID- 4327994 TI - The bronchial epithelium. Nucleic acid content in morphologically normal, metaplastic and neoplastic bronchial mucosae. A microspectrophotometric study of biopsy material. PMID- 4327996 TI - Foodborne outbreak of gastroenteritis possibily of multiple bacterial etiology. PMID- 4327995 TI - [3 cases of bronchiolar cancer with cardiopulmonary function studies]. PMID- 4327997 TI - Control of respiratory disease in recruits with types 4 and 7 adenovirus vaccines. PMID- 4327998 TI - Studies of canine respiratory viruses. I. Experimental infection of dogs with an SV5-like canine parainfluenza agent. PMID- 4327999 TI - Characterization of four new adenovirus serotypes isolated from chimpanzee tissue explants. PMID- 4328000 TI - [Immunization of hamsters against tumors induced by the SV40 virus]. PMID- 4328002 TI - [Effects of perfringens toxin on phagocytosis and leukocyte viability]. PMID- 4328003 TI - [Effect of herpes simplex virus (strain L2k5) and its mutants on the mitotic regime of cell cultures]. PMID- 4328001 TI - Antibody formation in cell cultures: immunoglobulins, cells and intercellular relationships during the secondary immune response to poliovirus. PMID- 4328004 TI - [The liver and the renin-angiotensin system]. PMID- 4328005 TI - Ultrastructure of calcium phosphate-containing cells in the serpulid polychaete worm Pomatoceros caeruleus. PMID- 4328006 TI - The release of extracellular enzymes from yeast by "osmotic shock". PMID- 4328007 TI - A spin label study of sarcoplasmic vesicles. PMID- 4328008 TI - [On the activity of a liver-protective drug, uridine-5-diphosphoglucose as an adjuvant in dermatological therapy]. PMID- 4328009 TI - Human casein. 3. DEAE-cellulose-urea chromatography of human casein and dephosphorylation of casein fractions. PMID- 4328010 TI - Tumor immunity in hamsters immunized with fetal tissues. PMID- 4328011 TI - Association of polypeptides with ribonucleic acid. I. Effect of charge of the polypeptide and immune status of animals. PMID- 4328012 TI - Regulation of homocytotropic antibody formation in the rat. IV. Effects of various immunosuppressive drugs. PMID- 4328013 TI - The role of cyclic AMP in the cytolytic activity of lymphocytes. PMID- 4328014 TI - Release of adrenal catecholamines by angiotensin I. PMID- 4328015 TI - Renal response to aminophylline in relation to hydration and exogenous vasopressin. PMID- 4328016 TI - The nature of the prostaglandin-blocking activity of polyphloretin phosphate. PMID- 4328017 TI - Procaine, pentobarbital and halothane: effects on the mammalian myoneural junction. PMID- 4328019 TI - Decline in the mean integrated electroencephalogram voltage during morphine abstinence in the rat. PMID- 4328018 TI - Effect of psychotropic drugs on tryptophan concentration in the rat brain. PMID- 4328021 TI - Differential effects of prostaglandins E 1 , E 2 , F 1 and F 2 on adrenergic vasoconstriction in the dog hindpaw. PMID- 4328020 TI - Interaction between angiotensin and bloodborne exogenous norepinephrine on the cat nictitating membrane in vivo. PMID- 4328022 TI - Arterial baroreceptor responses to intraaortic balloon assistance. PMID- 4328023 TI - [Case of hypoplastic congenital anemia of the Josephs-Blackfan-Diamond type with chromosome abnormalities]. PMID- 4328024 TI - Inactivation of Rous sarcoma virus on contact with N-ethyl isatin thiosemicarbazone. PMID- 4328025 TI - Inverse relationship of polyoma tumour specific cell surface antigen to H-2 histocompatibility antigens. PMID- 4328026 TI - Further observations on acetylcholine noise. PMID- 4328027 TI - Electronoptic demonstration of the virus in experimental mouse erythroleukaemia. PMID- 4328028 TI - Changes in blood plasma enzyme activity during intra-arterial chemotherapy of cancer. PMID- 4328029 TI - Approach to the patient with hypertension. PMID- 4328030 TI - Value of the magnitude of muscle action potentials. PMID- 4328031 TI - [Therapy of nephrotic syndrome]. PMID- 4328033 TI - Synaptic transmission in the sympathetic autonomic ganglia under conditons of experimental hypothyroidism in cat. PMID- 4328032 TI - [Research on the dynamics of the chemical processes in the stimulated salivary glands]. PMID- 4328034 TI - Some aspects of the carbohydrate metabolism after hypothalamic deafferentations. PMID- 4328036 TI - [The value of sputum and bronchial secretion examinations]. PMID- 4328035 TI - [Histology, tumor stage, life expectancy in bronchial carcinoma]. PMID- 4328037 TI - [Peptide hormones]. PMID- 4328038 TI - [Problems of antibiotic therapy of pyelonephritis during pregnancy]. PMID- 4328039 TI - The neural gland in tunicates: fine structure and intracellular distribution of phosphatases. PMID- 4328040 TI - [Our experience with use of the association of ACTH, marcaine and Frey's inhibitor in analgesia]. PMID- 4328042 TI - Magnetic resonance study of the Mn 2+ --lysozyme complex. PMID- 4328041 TI - [Effect of carbon tetrachloride on endoplasmic enzymes in rat liver]. PMID- 4328044 TI - Activity of polyadenosine diphosphoribose polymerase during the human cell cycle. PMID- 4328043 TI - A new type of histidine regulatory mutant in Escherichia coli. PMID- 4328045 TI - DNA of rat hepatomas: search for gene amplification. PMID- 4328046 TI - Studies on in vitro activation of high molecular weight pancreatic lipase. PMID- 4328048 TI - Glycans from streptococcal cell walls: glycosyl-phosphoryl moieties as immunodominant groups in heteroglycans from group D and group L streptococci. PMID- 4328047 TI - Chemical studies of Clq; a modulator of immunoglobulin biology. PMID- 4328049 TI - On the mechanism of the UDP-D-glucose-4'-epimerase. Evidence for a 3-keto-hexose intermediate. PMID- 4328050 TI - Mitochondrial alcohol dehydrogenase from Saccharomyces cerevisiae. PMID- 4328052 TI - Studies on a role of the 2,3-diphosphoglycerate phosphatase activity in the yeast phosphoglycerate mutase reaction. PMID- 4328051 TI - The nitrate reductase of Chlorella pyrenoidosa. PMID- 4328053 TI - Preparation and properties of collagenases from epithelium and mesenchyme of healing mammalian wounds. PMID- 4328055 TI - Titration of magnesium trisilicate mixture against gastric acid secretion. PMID- 4328054 TI - A radiometric assay for hepatic epoxide hydrase activity with [7-3H] styrene oxide. PMID- 4328056 TI - Delayed recovery of sympathetic transmission following ten years monoamine oxidase inhibition. PMID- 4328057 TI - Brain stem polysomes and avoidance performance of hypophysectomized rats subjected to peptide treatment. PMID- 4328058 TI - The effect of nicotinic acid, 5-methylpyrazole-3-carboxylic acid (U-19425), and dibutyryl cyclic AMP on renal gluconeogenesis. PMID- 4328059 TI - The renin-angiotensin system in newborn dogs. PMID- 4328060 TI - The sympathetic nervous system in short-term adaptation to cold. PMID- 4328061 TI - Ratios of nuclear proteins to DNA for rat and mouse tumors and possible effects of cytoplasmic fibrils in isolating nuclei. PMID- 4328062 TI - Glycosaminoglycans and electrokinetic behavior of rat ascites hepatoma cells. PMID- 4328063 TI - 3'5' AMP and Ca 2+ in slime mold aggregation. PMID- 4328064 TI - Renal protein absorption into sub-cellular particles. I. Studies with intact kidneys and fractionated homogenates. PMID- 4328065 TI - Identification of intracellular components by scanning electron microscopy. PMID- 4328066 TI - Regulation of DNA synthesis in macrophages infected with semian virus 40. PMID- 4328067 TI - Intact endoplasmic reticulum and albumin synthesis in rat liver cell suspensions. PMID- 4328068 TI - Metabolic patterns in Ilyanassa polar lobes. PMID- 4328069 TI - Comment on "Quartz as a dosimeter". PMID- 4328070 TI - [Treatment of renal tumors in childhood]. PMID- 4328071 TI - [Granular cell myoblastoma of the gluteal region. Report of a case and bibliographic review]. PMID- 4328072 TI - The stress response in the abundance of circulating leucocytes in the killi fish, Fundulus heteroclitus. 3. The role of the adrenal cortex and a concluding discussion of the leucocyte-stress syndrome. PMID- 4328073 TI - An evaluation of a dental prophylaxis preparation. PMID- 4328074 TI - The mechanism of endocrine influences on erythropoiesis. PMID- 4328075 TI - Effects of stilbestrol on the renal pressor system as modified by adrenalectomy and secondary aldosteronism. PMID- 4328076 TI - [Synthesis of a heptadecapeptide with high adrenocorticotropic effect]. PMID- 4328077 TI - [Physiologic and pharmacologic influence on insulin secretion]. PMID- 4328078 TI - [Hypoglycemia in newborn infants]. PMID- 4328079 TI - [Treatment of multiple sclerosis with Lyoproper]. PMID- 4328080 TI - [Lymphography does not provoke tumor metastasis]. PMID- 4328081 TI - The influence of hypnotics and tranquilizers on some evoked cortical potentials. PMID- 4328082 TI - Ganglionic transmission of somatically induced sympathetic reflexes. PMID- 4328084 TI - Multiple glomus tumours. PMID- 4328085 TI - Myasthenia gravis, ulcerative colitis and lichen planus. PMID- 4328087 TI - Granular cell myoblastoma. PMID- 4328086 TI - Circulating levels of plasma testosterone during sleep. PMID- 4328088 TI - [Analysis and evalution of virilogic and serologic findings during the epidemic of poliomyelitis in the city and province of Poznan]. PMID- 4328090 TI - [Circadian rhythm of the ACTH secretion under normal conditions and in the course of prolonged steroid therapy. Current notes]. PMID- 4328091 TI - [Bronchiectasis in childhood. Patient material--characteristics of therapy- results of follow-up examinations]. PMID- 4328089 TI - [Poliovirus-neutralizing antibodies in stools of poliomyelitis patients]. PMID- 4328092 TI - Comparison of 14- and 90-day tests in rats for liver enlargement and stimulation of drug-metabolizing enzymes induced by the agricultural fungicide EL 241. PMID- 4328093 TI - The pattern of human eye movements during sleep. PMID- 4328094 TI - Regional distribution of cyclic 3',5'-AMP in rat brain. PMID- 4328095 TI - The use of nitrosamine induced nervous system tumors of rats for biochemical investigation. PMID- 4328096 TI - A critique of the "myopathic" electromyogram. PMID- 4328097 TI - Myotonic discharges in various neurological syndromes: a neurophysiological analysis. PMID- 4328098 TI - Autogenic inhibition in patients with Parkinsonism: a neurophysiological study. PMID- 4328099 TI - Cerebral catecholamine concentration after L-dopa therapy in Parkinson's disease. PMID- 4328100 TI - Corticotropin therapy and thymectomy in management of severe, generalized myasthenia gravis. PMID- 4328101 TI - Virus induced cerebral sarcomas. PMID- 4328103 TI - The propagation of focal paroxysmal activity in the newborn macaca mulatta. PMID- 4328102 TI - Dopamine and blood pressure. PMID- 4328105 TI - Observations on dwarf layers particularly in the presence of Mareks disease in random sample tests at Ploufragan. PMID- 4328106 TI - [The role of different sleep stages in the development of convulsive paroxysms in sleep epilepsy (clinico-electrophysiologic study)]. PMID- 4328104 TI - Stress and the domestic fowl: a physiological appraisal. PMID- 4328107 TI - Single daily dose corticosteroid treatment. Effect on adrenal function and therapeutic efficacy in various diseases. PMID- 4328108 TI - The importance of the ionic strength of sucrose gradients in the determination of the sedimentation coefficient of poorly iodinated or newly synthesized thyroglobulin. PMID- 4328109 TI - Evidence for progressive, age-related structural changes in post-mature human collagen. PMID- 4328110 TI - Electron paramagnetic resonance spectroscopy of bovine cobalt carbonic anhydrase B. PMID- 4328111 TI - Nucleotides at the 5'-linked ends of bromegrass mosaic virus RNA and its fragments. PMID- 4328112 TI - Nucleolar and extranucleolar chromatin of rat Novikoff hepatoma cells. Separation and partial characterization of RNA polymerase activities. PMID- 4328113 TI - Nucleolar and extranucleolar chromatin of rat Novikoff hepatoma cells. A comparison of histone and non-histone protein acetylation. PMID- 4328115 TI - Reovirus core transcriptase and ethidium bromide: a continuous fluorimetric assay for polynucleotide synthesis based on the secondary structure of mRNA. PMID- 4328116 TI - Uptake of label into methylated amino acids from rat tissue histones after in vivo administration of (Me- 14 C)methionine. PMID- 4328114 TI - Replacement of Mg 2+ by monovalent cations in aminoacyl transfer RNA formation. PMID- 4328118 TI - [Strain of hamster embryonal fibroblasts transformed by Rous virus in vitro]. PMID- 4328120 TI - The energy metabolism of Novikoff ascites hepatoma cells. I. The effects of glucose on the intracellular level of adenine nucleotides. PMID- 4328121 TI - The temperature dependence of the electron paramagnetic resonance spectrum of ferricytochrome c solutions between 4.2 degrees K and 77 degrees K. PMID- 4328119 TI - The fixation and retention of viral and mammalian deoxyribonucleic acids on nitrocellulose filters. PMID- 4328122 TI - The enthalpy change of the hydrolysis of adenosine triphosphate by rat liver mitochondria. PMID- 4328123 TI - On the role of quinones in bacterial electron transport. Differential roles of ubiquinone and menaquinone in Proteus rettgeri. PMID- 4328125 TI - The linkage of phosphate groups and of 2-keto-3-deoxyoctonate to the lipid A component in a Salmonella minnesota lipopolysaccharide. PMID- 4328124 TI - The linkage of pyrophosphorylethanolamine to heptose in the core of Salmonella minnesota lipopolysaccharides. PMID- 4328126 TI - Nicotinamide mononucleotide. Determination of its enzymatic formation in vitro and its physiological role for the biosynthesis of nicotinamide-adenine dinucleotide in mice. PMID- 4328127 TI - Release of ethanolamine pyrophosphate during mild acid hydrolysis of the lipopolysaccharide of Pseudomonas aeruginosa. PMID- 4328128 TI - The effects of thyroxine on hepatic gluconeogenesis and ketogenesis in dairy cows. PMID- 4328129 TI - Calcium and the exportable protein in rat parotid gland. Parallel subcellular distribution and concomitant secretion. PMID- 4328131 TI - Potentiation of adrenergic venomotor responses by angiotensin, prostaglandin F 2 and cocaine. PMID- 4328130 TI - [Advances and principles in tuberculostatic therapy]. PMID- 4328132 TI - The pathologist and the surgical pathology of head and neck tumours. PMID- 4328133 TI - Effect of ovariectomy and of various hormones on the synthesis of progesterone by the guinea-pig placenta in vitro. PMID- 4328134 TI - Primary and metastatic tumors of the temporal bone. PMID- 4328135 TI - Effects of long-acting thyroid stimulator and prostaglandin antagonists on adenyl cyclase activity in isolated bovine thyroid cells. PMID- 4328136 TI - The complete enzymic hydrolysis of horse muscle acyl phosphatase. PMID- 4328138 TI - [Presbycusis and its therapeutic possibilities]. PMID- 4328139 TI - Influence of age and strain on the response of rats to dietary fructose and sucrose. PMID- 4328137 TI - Subcellular distribution of carbohydrates in transitional epithelium of urinary system. PMID- 4328141 TI - Pigmented nevi. PMID- 4328140 TI - Intraoral lesions of adults associated with herpes simplex virus. PMID- 4328142 TI - Early healing stages of dental pulp injuries in the light of morphological and histochemical investigations. PMID- 4328143 TI - Characterization of Ala-1 isolate of acute Marek's disease. PMID- 4328145 TI - Effect of metyrapone and DDD on infectious diseases. PMID- 4328144 TI - Field trials with the herpes virus of turkeys (HVT) strain FC126 as a vaccine against Marek's disease. PMID- 4328146 TI - Horizontal transmission of turkey herpesvirus to chickens. 1. Preliminary observation. PMID- 4328147 TI - Selection in chickens for retrogression of tumors caused by Rous sarcoma virus. PMID- 4328148 TI - Effects of increased vitamin D on calcium retention and egg shell calcification. PMID- 4328149 TI - [Electron transport system of microsomes]. PMID- 4328150 TI - [Biosynthesis of lipids]. PMID- 4328151 TI - [Aging of yeast mitochondria]. PMID- 4328152 TI - Methylation of nucleic acids and urinary excretion of 14 C-labeled 7 methylguanine by rats and man after administration of 4(5)-(3,3-dimethyl-1 triazeno)-imidazole5(4)-carboxomide. PMID- 4328153 TI - [Physiologic studies and further remarks on the structure of the light-sensitive pineal body of Pterophyllum scalare Cuv. et Val. (Cichlidae, teleostei)]. PMID- 4328154 TI - [Detection and differential diagnosis of glomus tumors of the middle ear and the jugular fossa]. PMID- 4328155 TI - [An unusual case of giant mixed tumor of the maxilla with proliferation into nasal and oral cavities]. PMID- 4328156 TI - [Primary cancer of the trachea]. PMID- 4328157 TI - [Chemodectoma of the middle ear]. PMID- 4328158 TI - Copper-catalyzed oxidation of thiomalic acid. PMID- 4328159 TI - Sarcoplasmic reticulum. XI. The mode of involvement of phospholipids in the hydrolysis of ATP by sarcoplasmic reticulum membranes. PMID- 4328160 TI - Studies of mitochondrial development during embryogenesis in the rat. PMID- 4328161 TI - ATP: glutamine synthetase adenylytransferase from Escherichia coli: purification and properties of a low-molecular weight enzyme form. PMID- 4328162 TI - Mn 2+ , and Zn 2+ 1:1 complexes with biochemically significant thioether carboxylic acids and some of the sulfoxide and sulfone derivatives. PMID- 4328163 TI - Labeling of rat liver glucose-1-phosphate, glucose-6-phosphate, uridine diphosphate glucose, and glycogen during glycogen synthesis. PMID- 4328164 TI - Tetrahydrodeoxyuridylate: a potent inhibitor of deoxycytidylate deaminase. PMID- 4328166 TI - [Epithelial nature of mixed tumors of the parotid gland. Histochemical and ultrastructural study]. PMID- 4328167 TI - [Case of synovial sarcoma localized in the retroperitoneum]. PMID- 4328165 TI - Purification and characterization of pre-phenoloxidase from hemolymph of the silkworm Bombyx mori. PMID- 4328168 TI - [Leiomyoblastoma: a pericytic neoplasm. Presentation of 3 cases]. PMID- 4328170 TI - [Hyperdactylia with tibial aplasia: a rare hereditary syndrome]. PMID- 4328169 TI - [Glomus tumor of the stomach. Case report]. PMID- 4328171 TI - Metabolism of 3 H-labelled lactate by rat adipose tissue. PMID- 4328172 TI - The anti-lipolytic action of prostaglandin E on isolated chicken fat cells. PMID- 4328173 TI - Major lipids of non-myelinated (olfactory) and myelinated (trigeminal) nerve of garfish, Lepisosteus osseus. PMID- 4328174 TI - Role of placenta in fetal lipid metabolism. 3. Formation of rabbit plasma phospholipids. PMID- 4328175 TI - Effects of dibutyryl cyclic adenosine 3',5'-monophosphate on glucose transport and metabolism in rat adipose tissue. PMID- 4328176 TI - The effects of killing or removal of animals affected with foot-and-mouth disease on the amounts of airborne virus present in looseboxes. PMID- 4328177 TI - Species differences in the formation in vitro of estrogen conjugates. PMID- 4328179 TI - [Plasmacytoma of the mastoid]. PMID- 4328178 TI - [Ulcero-mutilating neuropathies of the lower extremities. Clinical aspects of ulcero-mutilationg acropathy]. PMID- 4328180 TI - NMR studies on drug-receptor interactions. The binding of atropine and eserine to acetylcholinesterase. PMID- 4328181 TI - Digestibility of forages in vitro as affected by content of "silica". PMID- 4328182 TI - The site of the activity of extracellular products of Pseudomonas aeruginosa in the electron-transport chain in mammalian cell respiration. PMID- 4328183 TI - Replication of herpes simplex virus in cultures of phytohemagglutinin-stimulated human lymphocytes. PMID- 4328184 TI - Electron microscopic study of fused cells, with special reference to chromosome pulvrization. PMID- 4328185 TI - A cell culture system for the assessment of tumor-promoting activity. PMID- 4328186 TI - Virus particles in rat mammary tumors of varying origin. PMID- 4328187 TI - Herpesvirus saimiri. V. Further evidence to consider this virus as the etiological agent of a lethal disease in primates which resembles a malignant lymphoma. PMID- 4328188 TI - Immunological determinants of avian sarcoma viruses: presence of group-specific antibodies in fowl sera demonstrated by complement-fixation inhibition test. PMID- 4328189 TI - Detection of Marek's disease antigen in feather follicle epithelium of chickens vaccinated against Marek's disease. PMID- 4328190 TI - Regional variations in primary liver cancer in ivory Coast. PMID- 4328191 TI - Trace-metal analysis of cancerous and noncancerous human tissues. PMID- 4328192 TI - Further studies on the replication of Marek's disease virus in the chicken and in cell culture. PMID- 4328193 TI - Plaque formation by Yaba virus in cynomolgus monkey kidney cells. PMID- 4328194 TI - Irradiation-induced lesions in germfree rats. PMID- 4328195 TI - Chromosomal changes in Syrian hamster cells transformed by simian virus 40 (SV40) and variants of defective SV40 (PARA). PMID- 4328196 TI - DNA measurement on cell nucleus of normal liver, adenoma, and hepatoma in mice: histologic features. PMID- 4328197 TI - Differences in susceptibility of human cells to mouse sarcoma virus. PMID- 4328198 TI - Enhanced transformation of human immunocompetent cells by dibutyryl adenosine cyclic 3',5'-monophosphate. PMID- 4328199 TI - Hepatocellular carcinoma metastatic to the mandible: report of case and review of literature. PMID- 4328200 TI - [Mechanical transmission in a receptor and its control--especially on the function of Lamellae]. PMID- 4328201 TI - Non-essential amino acid requirements of mammalian cells in tissue culture. PMID- 4328203 TI - Studies on the hyperplastic focus formation by variola virus in human cell cultures. 3. Virus growth and focus formation in HeLa cells cultured at supraoptimal temperatures. PMID- 4328202 TI - Comparative studies on the mode of neutralization reaction of poliovirus type 2 with serum IgG and secretory IgA from mother's milk and fecal extract. PMID- 4328204 TI - [Studies on the effect of antituberculosis agents against tubercle bacilli in the resting state, using streptomycin-dependent strain (18-b). I. Studies in vitro]. PMID- 4328206 TI - Non-enzymatic hydrolysis of transfer RNA by bull semen. PMID- 4328205 TI - Potentiation of angiotensin and eledoisin activities by sodium chloride. PMID- 4328207 TI - Metabolism of sorbitol modified by ethanol in rats fed with a choline-deficient or choline-supplemented low-protein high-fat diet. PMID- 4328208 TI - Viral aseptic meningitis: 12 years' experience. PMID- 4328209 TI - Secondary structure of DNA depends on base composition. PMID- 4328210 TI - Infection of tumour cells by fowl plague virus in the presence of actinomycin D. PMID- 4328211 TI - Antiviral activity of L-asparaginase. PMID- 4328212 TI - Evidence for formation of 1,25-dihydroxycholecalciferol during metabolism of vitamin D in man. PMID- 4328213 TI - Vitamin D metabolism in experimental uraemia: effects on intestinal transport 45 Ca and on formation of 1,25-dihydroxycholecalciferol in rat. PMID- 4328214 TI - [Drug-induced sleep]. PMID- 4328216 TI - Postal surveillance of acute respiratory virus infections in general practice. PMID- 4328215 TI - Debrisoquine, guanethidine, propranolol and human sleep. PMID- 4328217 TI - [Mechanism of acquired immunity in ectromelia virus infection; application of neonatally thymectomized mice]. PMID- 4328218 TI - [Adenoma of the thymus gland and secretion of ACTH--study of a case]. PMID- 4328219 TI - [Screening of ectopic ACTH-producing tumor associated with lung neoplasms and 2 cases diagnosed by this method]. PMID- 4328220 TI - [Round table conference on production of ectopic hormones in lung and mediastinal neoplasms]. PMID- 4328222 TI - Multiple histiocytomata. A report of 3 patients. PMID- 4328221 TI - Effect of vinblastine on tissue cultures of human brain tumours. PMID- 4328223 TI - Feline herpesvirus associated with interstitial pneumonia in a kitten. PMID- 4328224 TI - Multihormonal, amyloid-producing tumour of the islets of Langerhans in a twelve year-old boy. Clinical, morphological and biochemical data and review of the literature. PMID- 4328225 TI - [Fine structue of the basal-cell adenoma of the salivary gland. A contribution of cell differentiation in salivary gland tumors]. PMID- 4328226 TI - [Features in the course of the hypertensive syndrome in supratentorial glioblastoma multiforme with regard to age]. PMID- 4328227 TI - [Echoencephalography of the exposed brain in supratentorial localization of a pathologic process]. PMID- 4328228 TI - [Rhythmic alternating electrogymnastic apparatus ESD-1 in neurosurgical clinical practice]. PMID- 4328229 TI - [Myocardial infarct. Tasks and possibilities of the general practitioner]. PMID- 4328230 TI - [Clinical-chemical examinations for early diagnosis of malignant brain tumors]. PMID- 4328231 TI - Kidney extracts and ACTH on adrenal steroid secretion in a turtle and a crocodilian. PMID- 4328232 TI - Thermal bradycardia in the mildly stressed rat. PMID- 4328233 TI - [Gradients of cytological maturation of ganglioneuroblastoma. With 2 cases]. PMID- 4328234 TI - [Glomus tumor of unusual site]. PMID- 4328235 TI - Changes in the threshold of the recruiting responses during sleep and wakefulness: a quantitative study. PMID- 4328237 TI - Histochemical studies of chick embryo chorio-allantoic membranes infected with vaccinia and smallpox viruses. I. Glycogen, glycoproteins and mucopolysaccharides. PMID- 4328236 TI - [Histochemical study of an experimental model of reversible liver cirrhosis]. PMID- 4328238 TI - [Localizing value of optokinetic nystagms retractorius in Parinaud's syndrome]. PMID- 4328239 TI - [Vesiculiform dystrophy grouped in islets and bands of the corneal endothelium (Schnyder's posterior herpes)]. PMID- 4328240 TI - Effect of oxygen on freezing damage. II. Physical-chemical effects. PMID- 4328241 TI - Studies on the mechanism of freezing damage to mouse liver using a mitochondrial enzyme assay. 3. Cryophyllaxis with dimethyl sulfoxide and enzyme localization. PMID- 4328242 TI - Cessation of steroidogenesis in Leydig cell tumors after removal of luteinizing hormone and adenosine cyclic 3',5'-monophosphate. PMID- 4328243 TI - The regulation of hepatic triglyceride metabolism by free fatty acids. PMID- 4328245 TI - [A study on corticotropin releasing factor in the blood of the hypophysial portal vessels in dogs]. PMID- 4328244 TI - Pork liver guanosine diphosphate-L-fucose glycoprotein fucosyltransferases. PMID- 4328246 TI - Zinc and smooth muscle contractility. I. Study of the mechanisms of zinc-induced contractility changes in rat uteri. PMID- 4328247 TI - The activation of glycogen phosphorylase in arterial smooth muscle. PMID- 4328248 TI - The pharmacology of d- and l-carnitine and d- and l-acetylcarnitine. Comparison with choline and acetylcholine. PMID- 4328250 TI - Carbenicillin and other antibiotics for therapy of Pseudomonas infections. PMID- 4328249 TI - Effects of carbon tetrachloride on the metabolism of liver glycogen in the rat. PMID- 4328251 TI - [On glomus tumors of the stomach]. PMID- 4328252 TI - Presence of cell and virus specific sequences in the same molecules of nuclear RNA from virus transformed cells. PMID- 4328253 TI - "Disjunction" of frog neuromuscular synapses by treatment with proteolytic enzymes. PMID- 4328254 TI - [Steroid therapy in the surgical treatment of diffuse toxic goiter]. PMID- 4328255 TI - Duration of resistance to viral infection following administration of interferon inducers. PMID- 4328256 TI - Immunological studies on mouse mammary tumors and leukemia. PMID- 4328257 TI - Studies on the relationship of leukemia in animals and man. PMID- 4328258 TI - [Microbial flora of the pharynx and dynamics of immunologic reactions in acute respiratory diseases in children]. PMID- 4328259 TI - [Immunochemical study of the antigenic structure of Bordetella genus bacteria. I. Immunoelectrophoretic analysis of the antigenic structure of different strains of Bordetella pertussis and their biological properties]. PMID- 4328260 TI - [Isolation of agglutinogen complex from Bordetella pertussis of various serological types]. PMID- 4328261 TI - [Immunologic structure of different age groups of the population of Lugansk in relation to adenoviruses]. PMID- 4328262 TI - Parathyroid hormone and thyrocalcitonin: their mode of action and regulation. PMID- 4328263 TI - Gene therapy systems: the need, experimental approach, and implications. PMID- 4328264 TI - Allopurinol and oxipurinol: alteration of purine and pyrimidine metabolism in cell culture. PMID- 4328265 TI - Early events in hormonal induction of alkaline phosphatase in human cell culture: hormone-cell interaction and its dependence of DNA replication. PMID- 4328266 TI - [Cancer of the vulva]. PMID- 4328268 TI - [Control and handling of the interferon inducer Poly rI-Poly rC]. PMID- 4328267 TI - Analysis of mortality after prolonged treatment of rats with high doses of a depot form of tetracosactide. PMID- 4328269 TI - The pharmacology of 1,6-dimethyl-3-carbethoxy-4-oxo-6,7,8,9 tetrahydrohomopyrimidazol-methylsulphate (MZ-144), a new, potent, non-narcotic analgesic. II. Toxicity and analgetic effect of MZ-144 compared to narcotic and non-narcotic analgesics. PMID- 4328270 TI - Protection of animals against soman (1,2,2-trimethylpropyl methylphosphono fluoridate) by pretreatment with some other organophosphorus compounds, followed by oxime and atropine. PMID- 4328271 TI - Alteration of liver glutamic dehydrogenase by chlorpromazine. PMID- 4328273 TI - Modification by spychotropic drugs of the cyclic adenosine monophosphate response to norepinephrine in rat brain. PMID- 4328272 TI - Inhibition of aldehyde dehydrogenase by 2-chloroacetophenone and the resultant effects on the catabolism of norepinephrine in brain. PMID- 4328274 TI - Cyclic adenosine 3',5'-monophosphate and enylcyclase in liver, adipose tissue and brain of rats treated with beta-pyridylcarbinol. PMID- 4328275 TI - Biochemical activities of tubercidin 3',5'-cyclic monophosphate in rat epididymal adipose tissue. PMID- 4328277 TI - Discharges in Purkinje cell axons during climbing fiber activation. PMID- 4328276 TI - Uptake and distribution of 4,4'-diacetyl-diphenyl-urea-bis-guanylhydrazone in sensitive and resistant sarcoma 180 cells in vitro. PMID- 4328278 TI - Changes in cyclic 3',5'-adenosine monophosphate-dependent protein kinase levels in brain development. PMID- 4328279 TI - [Is there a metabolic DNA?]. PMID- 4328280 TI - Studies on the anti-tumour activity of aliphatic aldehydes. 3. Formation of thiazoildine-4-carboxylic acid in tissues. PMID- 4328281 TI - Relation between the pathological nature and the growth rate of human tumors. PMID- 4328282 TI - Virus-like particles in L5178Y murine leukaemic cells. PMID- 4328283 TI - The susceptibility to SV40 virus transformation of fibroblasts obtained from patients with Down's syndrome. PMID- 4328285 TI - [Hazards of thromboembolism in lymphography (blood coagulation tests)]. PMID- 4328284 TI - [Enzyme studies during endolymphatic 131-I-lipiodol instillation]. PMID- 4328286 TI - Carcinoma of the breast in a girl aged fourteen. PMID- 4328287 TI - Evidence for a human breast cancer virus. PMID- 4328288 TI - Sensitivity of Artemia eggs to -irradiation. IX. A correlation between radiation induced free radicals and hatchability in eggs exposed to -mercaptoethylamine. PMID- 4328289 TI - Radiation-induced single-strand breaks in double-stranded circular DNA. PMID- 4328290 TI - Immunohistologic studies of synoviocytes and synovial exudate cells. PMID- 4328291 TI - Infectious virus-antibody complexes: interaction with anti-immunoglobulins, complement, and rheumatoid factor. PMID- 4328292 TI - Pathogenesis of immune complex glomerulonephritis of New Zealand mice. PMID- 4328293 TI - Axonal degeneration in diphtheritic neuropathy. PMID- 4328294 TI - Notes on the influence of adrenocorticotrophic hormone on platelet stickiness in multiple sclerosis. PMID- 4328295 TI - The neurosurgical treatment of glomus jugulare tumors. PMID- 4328296 TI - Granular cell myoblastoma of the neurohypophysis. Report of two cases. PMID- 4328297 TI - Angiofibroma of the middle cranial fossa. Case report. PMID- 4328298 TI - Malaysia and its problems. PMID- 4328299 TI - Anti-EB virus antibody titer in sera collected from human subjects of Surabaja, Indonesia, in 1968. PMID- 4328300 TI - Stimulation of [ 14 C] tryptophan 5-hydroxylation by norepinephrine and dibutyryl adenosine 3', 5' monophosphate in rat pineal organ cultures. PMID- 4328301 TI - Pathogenesis of bacterial diarrheas. I. PMID- 4328302 TI - Infantile spasms associated with 5-hydroxytryptophan administration in patients with Down's syndrome. PMID- 4328303 TI - Familial brachial neuropathy. Two case reports with discussion. PMID- 4328304 TI - Pseudomonas meningitis related to spinal anesthesia. Report of three cases with a common source of infection. PMID- 4328305 TI - [Axillary lymph drainage of the mammary glands]. PMID- 4328306 TI - [Studies of insulin concentration in portal blood]. PMID- 4328307 TI - [Development of ovarian tumors in rats caused by intrasplenic transplants]. PMID- 4328308 TI - Vitamin D: a new look at an old vitamin. PMID- 4328309 TI - Canine mammary tumors. PMID- 4328310 TI - Ultrastructural nature of canine distemper inclusions in the urinary bladder. PMID- 4328311 TI - [Primary malignant tumors of the liver]. PMID- 4328312 TI - Paradoxical response to dexamethasone-suppression in Cushing's disease with adrenal hyperplasia. PMID- 4328313 TI - [Adrenal circadian rhythm and delayed-action corticoids]. PMID- 4328314 TI - [Eruption erythematous aphthous stomatitis: primary herpes infection?]. PMID- 4328316 TI - [Adenoma papillae mammae. A review and 6 case reports]. PMID- 4328315 TI - Ultrastructural studies of the hepatic changes brought about by Clindamycin and Erythromycin in animals. PMID- 4328317 TI - [Light and electron microscopy studies on brain tissue changes in acute experimental oxygen intoxication]. PMID- 4328319 TI - Dream recall. PMID- 4328318 TI - [X-ray symptomatology of the female breast carcinoma]. PMID- 4328320 TI - Reduction in hospitalization of schizophrenics. PMID- 4328321 TI - REM and SWS sleep: a clear division? PMID- 4328322 TI - Eye movements during sleep. I. The pattern in the normal human. PMID- 4328323 TI - Two cases of mammary neoplasms arising in male dogs. PMID- 4328324 TI - Action of the fungicides captan and folpet on rat liver mitochondria. PMID- 4328325 TI - 6-Methylthioguanylic acid, a metabolite of 6-thioguanine. PMID- 4328326 TI - Protection by 2-diethylaminoethyl-2,2-diphenylvalerate hydrochloride against carbon tetrachloride hepatotoxicity. A possible mechanism of action. PMID- 4328328 TI - Mechanism of action of antipsychotic drugs on biological electron transport. PMID- 4328327 TI - Inhibition of renin by sodium deoxycholate. PMID- 4328330 TI - Familial amyloid polyneuropathy: an electron microscope study of the peripheral nerve in five cases. II. Nerve fibre changes. PMID- 4328329 TI - Familial amyloid polyneuropathy: an electron microscope study of the peripheral nerve in five cases. I. Interstitial changes. PMID- 4328331 TI - Antibodies against -globulin after blood transfusion and cytomegalovirus infection. PMID- 4328332 TI - The role of the corpus callosum in the establishment of areas of secondary epileptiform activity. PMID- 4328334 TI - Afferent volleys in limb nerves influencing impulse discharges in cerebellar cortex. II. In Purkyne cells. PMID- 4328335 TI - Dopamine: a retinal neurotransmitter. II. Autoradiographic localization of H3 dopamine in the retina. PMID- 4328336 TI - Viral respiratory disease in cats. PMID- 4328337 TI - Differences between ectopic MSH and pituitary MSH. PMID- 4328338 TI - The response of human adrenocorticotrophic hormone and growth hormone to surgical stress. PMID- 4328339 TI - Congenital adrenal hyperplasia due to deficiency of 11 -hydroxylation of 17 hydroxylated steroids. PMID- 4328340 TI - Metabolic changes in women with trophoblastic disease and with intrauterine fetal death compared with metabolic changes during normal pregnancy. PMID- 4328341 TI - The use of insulin dynamics in the evaluation of streptozotocin therapy of malignant insulinomas. PMID- 4328342 TI - Parathyroid hormone-sensitive adenyl cyclase from the renal cortex of a patient with pseudohypoparathyroidism. PMID- 4328344 TI - Competitive binding assay for vitamin D and 25-OH vitamin D. PMID- 4328343 TI - Iodination of angiotensin I for use in radioimmunoassay. PMID- 4328345 TI - Mediation by -adrenergic receptors of effect of norepinephrine on pineal synthesis of ( 14 C)serotonin and ( 14 C)melatonin. PMID- 4328346 TI - Enzymic activities associated with membranous cytoplasmic bodies and isolated brain lysosomes. PMID- 4328348 TI - Uremic neuropathy. PMID- 4328347 TI - Localization of adenosine 3',5'-monophosphate-dependent protein kinase in brain. PMID- 4328349 TI - Adrenocortical reserve in infancy and childhood. PMID- 4328350 TI - Arteriography and hypoglycemia. PMID- 4328351 TI - [Liver function in primary and secondary liver tumors]. PMID- 4328352 TI - Electron transport in parasitic helminths and protozoa. PMID- 4328353 TI - The pathogenesis of retinal dysplasia. PMID- 4328354 TI - Evaluation of 48 cases of orbital exenteration. PMID- 4328355 TI - [EPR study of the nature and properties of paramagnetic centers in gamma irradiated proteins]. PMID- 4328356 TI - [Endogenous nitrosyl complexes of heme and non-heme iron in microorganisms and animal tissues]. PMID- 4328357 TI - [Electric conductivity of suspensions of normal and neoplastic cells]. PMID- 4328358 TI - [Quantitative study of EPR spectra of frozen preparations of animal tissues]. PMID- 4328359 TI - [Contribution of the nerve impulse to a stationary regime of propagation]. PMID- 4328360 TI - [Some properties of a group of neurons working in parallel. II. Role of inhibitory and excitatory connections between neurons]. PMID- 4328362 TI - [Conditions for measurement of small concentrations of adenosine cyclic 3',5' monophosphate by an enzymatic method]. PMID- 4328361 TI - [Relation of EPR signals of liver RNA to liver function]. PMID- 4328363 TI - Changes in the amount and properties of adenyl cyclase in brown adipose tissue during acclimation of rats to cold. PMID- 4328364 TI - Esophageal obstruction secondary to mediastinal metastasis from breast carcinoma. PMID- 4328365 TI - Electroencephalographic measures of melanocyte-stimulating hormone activity. PMID- 4328366 TI - Attenuation of rat vocalizations to shock by a stimulus: sensory interaction effects? PMID- 4328367 TI - Peripheral neuropathy after disulfiram administration. AB - Peripheral neuropathy and optic neuritis occurring in alcoholics are sometimes due to the toxic effects of disulfiram rather than to alcohol. Unless this is considered in the management of such patients it is likely that administration of the drug will be continued. In the past there have been reports of 16 cases of peripheral neuropathy and six cases of optic neuritis, possibly caused in this way; these reports are reviewed and a further six cases are described. The effects of disulfiram on the nervous system are briefly discussed. PMID- 4328368 TI - Histochemically demonstrable fibre abnormalities in normal skeletal muscle and in muscle from carriers of Duchenne muscular dystrophy. AB - Deltoid muscle was removed at motor point biopsy from 10 female relatives of patients with Duchenne muscular dystrophy and from seven others, with no evidence of neuromuscular disease. Transverse cryostat sections of the muscle from each case were stained for reduced diphosphopyridine nucleotide diaphorase and it was found that all contained varying numbers of degenerating type 1 fibres. The percentage of abnormal fibres in the type 1 fibre population was then calculated for each case and it was found that the muscles from the patients with dystrophic relatives contained considerably higher percentages of abnormal fibres, which also showed more severe degeneration, than did the muscles from the normal cases. There was no absolute correlation between serum creatine kinase levels and degree of pathological change, though patients with the most severe changes in their muscles had abnormally high serum creatine kinase levels. It is suggested that histochemical studies could be a useful addition to the present diagnostic tests for the carrier state in Duchenne muscular dystrophy. PMID- 4328369 TI - Brain scans in pituitary tumors. PMID- 4328370 TI - Congenital failure of myelinization: Pelizaeus-Merzbacher disease? PMID- 4328372 TI - Influence of age and castration on reactivity of guinea pig isolated seminal vesicles to angiotensin and tyramine. PMID- 4328371 TI - Subacute demyelinating disease in an adult (diffuse-disseminated sclerosis). PMID- 4328373 TI - [Polycystic ovaries. I. Experimental bases, clinical and bioclinical data (102 cases)]. PMID- 4328374 TI - [Attemp at treatment of acute leukemia and Hodgkin's disease by rubidomycin or daunomycin alone or combined]. PMID- 4328375 TI - [Metabolic and circulatory resuscitation in normally formed infants born at term]. PMID- 4328376 TI - [Hypochromic anemia in adults]. PMID- 4328378 TI - Inhibition of tumor growth with a new synthetic ribonucleic acid. PMID- 4328377 TI - Amelioration of the side effects of cyclophosphamide. PMID- 4328379 TI - Methods for selective removal of intima in diseased arteries. PMID- 4328380 TI - Sympathetic cardiac drive in sepsis. PMID- 4328381 TI - Immunosuppressive effects of macrophage lysis. PMID- 4328382 TI - The effect of adrenalectomy and endocrine substances on restraint-induced acute gastric ulceration. PMID- 4328383 TI - Histochemical studies of tendon healing. PMID- 4328384 TI - Bone collagenase in osteolytic stress of rats and humans. PMID- 4328385 TI - [Complications of contrast media]. PMID- 4328386 TI - [Modification of steroid and corticotropin therapeutic administration in some inferior chronic aspecific respiratory affections (I.C.A.R.A.)]. PMID- 4328388 TI - Experimental cyanide optic neuropathy. PMID- 4328387 TI - Ultrastructural ocular pathology of Hunter's syndrome. Systemic mucopolysaccharidosis type II. PMID- 4328389 TI - The retina and optic nerve. PMID- 4328390 TI - Opsoclonus as the initial manifestation of occult neuroblastoma. PMID- 4328392 TI - Glycopeptides from silk fibroin of Bombyx mori. PMID- 4328391 TI - Enzymic control of fructolysis in primate spermatozoa. PMID- 4328393 TI - The development of adenyl cyclase in rat liver, kidney, brain and skeletal muscle. PMID- 4328394 TI - Metabolism of 3',5'-cyclic amp by strains L cells. PMID- 4328395 TI - Compounds known to affect the cyclic adenosine monophosphate level in blood platelets: effect on thrombin-induced clot retraction and platelet release. PMID- 4328396 TI - Nicotinamide adenine dinucleotide in developing chick embryo. PMID- 4328397 TI - The configuration of the 1,2-dihydroxy-1,2-dihydronaphthalene formed in the bacterial metabolism of naphthalene. PMID- 4328399 TI - Hereditary hemolytic anemia associated with abnormal membrane lipids: mechanism of accumulation of phosphatidyl choline. PMID- 4328398 TI - Modification of cytochrome c with N-methyl-N'-nitro-N-nitrosoguanidine. PMID- 4328400 TI - Gaucher's cells in thalassemia. PMID- 4328401 TI - A longitudinal comparison of antibodies to Epstein-Barr virus and clinical parameters in chronic lymphocytic leukemia and chronic myelocytic leukemia. PMID- 4328402 TI - Lymphocyte membrane enzymes. II. Cyclic 3',5'-adenosine monophosphatase located on unstimulated human small lymphocyte nuclear membranes. PMID- 4328403 TI - Enterogenous cysts of the rectum (colitis cystica profunda). PMID- 4328404 TI - The above-knee amputation for ischaemia. PMID- 4328405 TI - Unusual presentation of seminoma of the testis. PMID- 4328406 TI - Further studies of patients with the cardiofacial syndrome. PMID- 4328407 TI - Extra lactate dehydrogenase isoenzyme band in serum of patients with severe liver disease. PMID- 4328408 TI - Stimulation of non-specific resistance by heterologous endotoxins and experimental immunity to Bordetella pertussis in mice. PMID- 4328409 TI - Effect of temperature on the cleavage of polypeptides during growth of LSc poliovirus. PMID- 4328410 TI - Motor neurone disease. Further evidence for an abnormality of nerve metabolism. AB - Physiological and biochemical studies were carried out on 16 patients with motor neurone disease (MND). It was confirmed that the peripheral nerves in cases of MND are often unusually resistant to ischaemia especially as regards the large sensory fibres. Biochemical investigations demonstrated a tendency to carbohydrate intolerance and abnormal pyruvate metabolism. When compared with other related studies in MND it seems very likely that there is a metabolic abnormality present in MND which demands further study. PMID- 4328411 TI - Deoxyribonucleic acid polymerase(s) of Rous sarcoma virus: effects of virion associated endonuclease on the enzymatic product. AB - Purified preparations of Rous sarcoma virus (RSV) contain ribonuclease which is either a constituent of the virion surface or an adsorbed contaminant. Treatment of the virus with nonionic detergent to activate ribonucleic acid (RNA)-dependent deoxyribonucleic acid (DNA) polymerase renders the viral genome susceptible to hydrolysis by the external ribonuclease. The extent of this susceptibility can be substantially reduced by the use of limited amounts of detergent. At a concentration of detergent which provides a maximum initial rate of DNA synthesis, the degradation of endogenous viral RNA results in a reduced yield of high molecular weight DNA: RNA hybrid from the polymerase reaction. Attempts to detect virion-associated deoxyribonuclease, by using a variety of double helical DNA species as substrates, have been unsuccessful, but small amounts of nuclease activity directed against single-stranded DNA may be present in purified virus. PMID- 4328412 TI - Effect of inactivation by hydroxylamine on early functions of poliovirus. AB - Evidence is presented that poliovirus particles with a single lethal hit by hydroxylamine do not induce in host cells either inhibition of cellular protein synthesis or viral ribonucleic acid (RNA) replication. The RNA of these viruses is not replicated even if the cells are simultaneously infected with both active and inactivated viruses. The damaged viral RNA seems to have lost both its template function and its function in the translation of normal viral proteins. PMID- 4328413 TI - Differential effect of phleomycin on the infectivity of poliovirus and poliovirus induced ribonucleic acids. AB - The infectivity of intact poliovirus was not affected by exposure to the antibiotic phleomycin at concentrations as high as 200 mug/ml, whereas that of the singlestranded poliovirus ribonucleic acid (RNA) was inactivated to 99% by pretreatment of the RNA with phleomycin at a concentration of 2 mug/ml. The infectivity of double and multistranded RNA was 10 times less sensitive than that of singlestranded RNA to the action of this antibiotic. Preincubation of HeLa cells for 30 min with 10 to 50 mug of phleomycin reduced the sensitivity of the cells to infection by viral RNA and intact virus, indicating that phleomycin interferes with cellular functions necessary for virus replication. When phleomycin was added to cells at different times after infection with single- or double-stranded RNA, the highest inactivation of infective centers was observed immediately after infection. With time of incubation at 37 C, the infective centers became more resistant to the action of phleomycin. PMID- 4328414 TI - Influence of polycations on the interaction between poliovirus multistranded ribonucleic acid and HeLa cells. AB - In contrast to single-stranded viral ribonucleic acid (RNA), poliovirus multistranded RNA (RI-RNA) is poorly adsorbed to suspended HeLa cells in the absence of polycations. In the presence of 20 mug of diethylaminoethyl (DEAE) dextran per ml and other polycations, 90% or more of the RI-RNA is adsorbed to HeLa cells within 2 min at 37 C. However, only 30% of the RI-RNA label penetrates into the cells independent of the concentration of DEAE dextran applied. DEAE dextran is adsorbed almost quantitatively to HeLa cells within 3 min at 37 C. Most of the DEAE dextran remains bound to the cell membrane and available for binding of RI-RNA for 15 min at 37 C. PMID- 4328415 TI - Preliminary physiological characterization of temperature-sensitive mutants of vesicular stomatitis virus. AB - Different temperature-sensitive mutants of vesicular stomatitis virus have been characterized in terms of their ability to induce synthesis of viral ribonucleic acid (RNA) in BHK-21 cells at 39 C (the restrictive temperature for these mutants). Mutants belonging to complementation groups I and IV (and probably II) did not induce actinomycin-resistant RNA synthesis in infected cells incubated at 39 C. All three mutants comprising complementation group III induced viral RNA synthesis at 39 C. The temperature sensitivity of the defective viral functions has also been studied by temperature-shift experiments. The functions associated with the mutants of groups I, II, and IV were required early, whereas the function associated with the group III mutants was not required until a late stage of the viral cycle. The heat sensitivity of extracellular virion was not correlated with complementation group. PMID- 4328416 TI - Mechanism of oncogenic transformation by Rous sarcoma virus. II. Effect of rifampin on Rous sarcoma virus infection. AB - Rifampin partially inhibits focus formation and virus production in chick embryo fibroblasts infected with Bryan high-titer Rous sarcoma (RAV-1) virus. This inhibition occurs with exposure to rifampin during a critical period between day 1 and day 2 after infection. This suggests that the drug does not affect formation of the provirus or its transcription or translation after the "fixation" step, but it seems to affect one or more events which take place before fixation and activation of virus production. PMID- 4328417 TI - Transcription of the influenza ribonucleic acid genome by a virion polymerase. I. Optimal conditions for in vitro activity of the ribonucleic acid-dependent ribonucleic acid polymerase. AB - In vitro reaction conditions have been determined for the maximal synthesis of product ribonucleic acid by the influenza (WSN) virion ribonucleic acid polymerase. The reaction requires the presence of all four triphosphates, Mg(2+) and Mn(2+) ions, monovalent cations, nonionic detergent, and ribonucleoside triphosphates at concentrations above certain threshold values. The optimum pH for the reaction is around 8.0 to 8.2 and the kinetics of product synthesis are linear through at least 6 hr when incubated at 31 to 33 C. PMID- 4328418 TI - Ribonucleic acid polymerase activity in Sendai virions and nucleocapsid. AB - After dissociation of purified Sendai virus with the neutral detergent Nonidet P 40 and 2-mercaptoethanol, it catalyzed the incorporation of ribonucleoside triphosphates into an acid-insoluble product. The enzyme activity was associated with viral nucleocapsid as well as whole virions. The reaction product was ribonucleic acid (RNA) which annealed specifically with virion RNA. Sedimentation of the (3)H-RNA reaction product revealed two components, a 45S component with properties of double-stranded RNA and 4 to 6S component which appeared to be mostly single-stranded RNA. PMID- 4328419 TI - [Werner's syndrome]. PMID- 4328420 TI - Effective low cost aftercare. PMID- 4328421 TI - Effects of oligomycin on the (Na + + K + )-dependent adenosine triphosphatase. PMID- 4328423 TI - [Nuclear medicine in the diagnosis of heart diseases]. PMID- 4328422 TI - Mechanism of the inhibition of aldehyde dehydrogenase in vivo by disulfiram and diethyldithiocarbamate. PMID- 4328424 TI - [Liver cancer associated with a large spheric thrombus caused by tumor in the right atrium of the heart]. PMID- 4328425 TI - Patterns of regeneration between individual nerve cells in the central nervous system of the leech. PMID- 4328426 TI - Binding of 3 H-concanavalin A by normal and transformed cells. PMID- 4328427 TI - Binding of radioactively labelled concanavalin A and wheat germ agglutinin to normal and virus-transformed cells. PMID- 4328428 TI - [Ultrastructural morphology of the human hypophysis]. PMID- 4328429 TI - [Electron microscope study of nervous system tumors]. PMID- 4328430 TI - Central synaptic transmitters. PMID- 4328431 TI - Optic neuritis and its relationship to disseminated sclerosis. PMID- 4328432 TI - Alcoholic neuropathy. PMID- 4328433 TI - Ciliary-structure precursor bodies as stable constituents in the sensory cells of the vomero-nasal organ of reptiles and mammals. PMID- 4328435 TI - Functional aspects of lysosomal organelles in blood platelets. PMID- 4328434 TI - The structure of the postantennal organ in Onychiurus sp. (Insecta:Collembola) and its connection to the central nervous system. PMID- 4328436 TI - [Our experiences with gastrectomy in the treatment of malignant neoplasms of the stomach]. PMID- 4328438 TI - Studies on experimental hypotrophy in the rat. II. Development of some liver enzymes of gluconeogenesis. PMID- 4328439 TI - Pathologic conditions in the patas moneky. PMID- 4328440 TI - Susceptibility of the common eland to infectious bovine rhiotracheitis viurs. PMID- 4328437 TI - [Tyramine tachyphylaxis; its recovery and interaction with enzyme inhibitors in arterial pressure and cat nictitating membrane]. PMID- 4328441 TI - Hepatoma in a Bengal tiger. PMID- 4328443 TI - A diazo compound for the photochemical labeling of yeast alcohol dehydrogenase. PMID- 4328442 TI - The glucagon-sensitive adenyl cyclase system in plasma membranes of rat liver. VI. Evidence for a role of membrane lipids. PMID- 4328444 TI - Preparation and properties of Rhodospirillum rubrum cytochromes c 2, cc', and b 557.5, and flavin mononucleotide protein. PMID- 4328446 TI - Amino sugars in the cell walls of Pseudomonas species. PMID- 4328445 TI - Ultrastructural evidence of secretion in hormonally active oat-cell carcinomas: origin of one such tumour in the pancreas. PMID- 4328447 TI - Allergic penicillin reactions. PMID- 4328448 TI - Choannal atresia. PMID- 4328449 TI - Pleomorphic adenoma of nasal septum. PMID- 4328450 TI - Bronchodilator activity of the prostaglandins E 1 and E 2 . PMID- 4328451 TI - Noradrenaline action on nerve terminal in the rat diaphragm. AB - 1. The mechanism by which noradrenaline increases the release of transmitter from the nerve terminal was investigated in the rat diaphragm.2. Increase of the frequency of the miniature end-plate potential (m.e.p.p.) was exponential when plotted against the intensity of a constant current which depolarized the nerve terminal. Noradrenaline (5 x 10(-6) g/ml.) did not change the slope of the curve showing the relationship between the logarithm of the frequency of m.e.p.p.s and the depolarizing current (m.e.p.p.-current relationship), but simply shifted the curve along the axis of the current towards weaker intensities.3. End-plate potentials (e.p.p.s) were evoked by passing a brief depolarizing pulse to the nerve terminal in the presence of tetrodotoxin (1 x 10(-7) g/ml.). A sigmoidal relationship was obtained between the amplitude of e.p.p. and the intensity of the current pulse (e.p.p.-current intensity relationship). Noradrenaline (5 x 10( 6) g/ml.) shifted the e.p.p.-current intensity relationship along the axis of the current intensity to smaller values, without any change in the maximum amplitude of e.p.p.s.4. The frequency of m.e.p.p. was increased, as the [Ca](0) was raised from 0.01 to 7.5 mM. An increase in [Ca](0) beyond the normal concentration (2.5 mM) had no remarkable effect on the action of noradrenaline. However, when [Ca](0) was reduced, the action of noradrenaline became weaker.5. A kinetic model in which the transmitter release is modified by the binding of Ca with a specific site in the nerve terminal may explain the results. According to this model, noradrenaline did not change the dissociation constant of the reaction between Ca and the specific site (X), but increased the rate constant of the Ca complex (CaX) for releasing acetylcholine.6. The action of noradrenaline was potentiated when [Na](0) was reduced, and suppressed when [Mg](0) was increased. The results may be summarized: that noradrenaline augments the probability of release of transmitter quanta from the resting nerve terminals and that this action can be intensified by first raising the probability of release by some other means. Depolarization of the nerve terminals by current, increase of the external Ca concentration, decrease of Na and decrease of Mg are all effective in promoting the action of noradrenaline. PMID- 4328453 TI - Drinking induced by injection of angiotensin II into the hypothalamus of the rhesus monkey. PMID- 4328452 TI - The responses of chemoreceptors at reduced temperatures. AB - 1. The responses of aortic chemoreceptors and pulmonary stretch receptors of cats were studied by recording impulses in individual fibres at normal body temperatures and thereafter at various temperatures down to 24-26 degrees C while cooling the cat with ice.2. Reduction of metabolism by lowering the temperature did not obviously slow the P(O2) sensing mechanism of chemoreceptors but it greatly slowed the development of excitation after circulatory arrest. It also greatly reduced the excitatory effect of hypoxia.3. The Q(10) for the frequency of discharge of chemoreceptors (during maximal activity) was estimated by comparing the activity of the endings at normal body temperature after circulatory arrest (i.e. at a local P(O2) of 0 mm Hg) with similar activity at reduced body temperatures. This averaged 2.5 in nine endings. The Q(10) for the peak frequency of discharge also averaged 2.5 in seven endings. These values are similar to those of some mechano-receptors.4. Apart from the reduction in the frequency of discharge (Q(10) = 2.6) lowering the temperature did not alter the stimulus-response relationship of pulmonary stretch receptors.5. The poor responses to ACh at lower temperatures indicate that ACh is not likely to be a transmitter at chemoreceptors. PMID- 4328454 TI - Can denervation hypersensitivity be prevented? PMID- 4328455 TI - [Primary tumor of the bronchial gland]. PMID- 4328456 TI - [Comparative histopathological study of biopsy and surgical specimens of stomach cancer]. PMID- 4328457 TI - AMP-sensitive fructose diphosphatase in wheat embryos: changes in levels of glycolytic intermediates during enzyme derepression. PMID- 4328458 TI - LDH isozymes during early hepatic regeneration. PMID- 4328459 TI - [Angiomas of the spinal cord and their surgical treatment]. PMID- 4328460 TI - [Ochre earth. Study on pneumoconiosis due to ochre earth and film presentation]. PMID- 4328461 TI - Bell's palsy. PMID- 4328462 TI - [Symptomatic ulcero-mutilant acropathy in tumors of the dauda equina]. PMID- 4328463 TI - [Comparative investigations on the enzymatic behavior of dermatotropic and non dermatotropic mycetes. 3. Study on the cytochemical behavior of leucinaminopeptidase and some hydrolases and enzymes of the energy-supplying metabolism in different gorwth phases of fungi]. PMID- 4328464 TI - [The influence of the medium osmolarity upon virus plaque formation in permanent cell cultures]. PMID- 4328465 TI - [Fibrosing spinal leptomeningitis (clinico-morphologic study)]. PMID- 4328466 TI - Microzone electrophoresis of unconcentrated cerebrospinal fluid using cellulose acetate strips and nigrosin dye. PMID- 4328467 TI - Cytomegalovirus inclusion disease at autopsy of patients with cancer. PMID- 4328468 TI - Light and electron microscopic studies of a malignant cystosarcoma phyllodes featuring stromal cartilage and bone. PMID- 4328469 TI - [Marek's disease and its control by vaccination]. PMID- 4328470 TI - [Eruption of small vesicles in the horse--an equine herpesvirus exanthema]. PMID- 4328471 TI - Genetic control of immune responsiveness to a glutamic acid, alanine, tyrosine copolymer in mice. I. Linkage of responsiveness to H-2 genotype. PMID- 4328472 TI - Characterization of precipitating antibody in equine infectious anemia. PMID- 4328473 TI - [Analysis of the pinching strength]. PMID- 4328474 TI - Antibiotics in the practice of periodontics. PMID- 4328475 TI - Synthesis and in vitro antimicrobial evaluation of hydrazones of 1-phenyl-, 1 benzyl-, and 1-benzhydryl-4-aminopiperazines. PMID- 4328476 TI - [Primary benign tumors of the trachea: description of a case of fibroangioma]. PMID- 4328477 TI - Preparation and characterization of an arylsulphatase insolubilized on porous glass. PMID- 4328478 TI - Possible role of cyclic AMP in the short term regulation of adrenal steroidogenesis. PMID- 4328479 TI - Electron microscopic study of the formation of bluetongue virus. PMID- 4328480 TI - [Influences of hypnotics (especially nitrazepam, -hydroxybutyric acid) on sleep wakefulness mechanisms in cats]. PMID- 4328481 TI - The Hempstead unitization experience. PMID- 4328482 TI - Calcium requirement for melanophore-stimulating hormone action on melanophores. AB - The calcium ion is specifically required for the action of melanophorestimulating hormone on melanosome dispersion within lizard (Anolis carolinensis) melanophores in vitro. The response to this hormone is directly related to the concentration of the Ca(2+) ion. Lithium, choline, rubidium, and cesium will replace the sodium and potassium of Ringer solution if Ca(2+) is present. Calcium ions are not required for melanosome dispersion itself, since theophylline or dibutyryl cyclic adenosine monophosphate reversibly darkens lizard skins in the absence of calcium. PMID- 4328483 TI - Latent herpes simplex virus in spinal ganglia of mice. AB - Herpes simplex virus establishes a persistent, latent infection in spinal ganglia after mice have recovered from posterior paralysis. Infectious virus is replicated when these ganglia are explanted and maintained as organ cultures in vitro. PMID- 4328484 TI - Cardiovascular physiology in acute salt depletion in dogs. PMID- 4328485 TI - New approach to management of renal abscess. PMID- 4328486 TI - Transplantation of the renal blastema: a new experimental model for the production of Wilms' tumor. PMID- 4328487 TI - Isolation of a rat-tropic helper virus from M-MSV-O stocks. PMID- 4328488 TI - Isolation and characterization of two group-specific antigens from feline leukemia virus. PMID- 4328489 TI - [Diseases of the exterior female genitalia. Adnexal neoplasms, cylindroma (Spiegler's tumor)]. PMID- 4328490 TI - [New derivatives obtained with 1-(2'-pyridyl)-benzotriazole-1,2,3 by Graebe Ullmann reaction in pyrophosphoric acid]. PMID- 4328492 TI - Aneurysm of the splenic artery associated with primary carcinoma of the liver and splenomegaly. PMID- 4328491 TI - In utero diagnosis of Niemann-Pick disease. PMID- 4328493 TI - [Clinical studies on surgery of the aged: evaluation of surgical risk]. PMID- 4328494 TI - Effect of orchiectomy on pituitary secretion of ACTH. PMID- 4328495 TI - Hypothalamic and pituitary regulation of adrenocortical function in the hamster: effects of gonadectomy and gonadal hormone replacement. PMID- 4328496 TI - Stimulatory effects of calcium on protein synthesis in adrenal (and thyroidal) cell-free systems as related to trophic hormone action. PMID- 4328497 TI - Quantitative histochemical study on the influence of lactation and changing levels of gonadotropic hormones on rat supraoptic nucleus. PMID- 4328498 TI - Inhibition of the hypercalcemic action of vitamin D 3 with imidazole. PMID- 4328499 TI - Stimulation of pregnenolone synthesis by ACTH in rat adrenal sections. PMID- 4328500 TI - ACTH and cyclic adenine nucleotides do not provoke identical adrenocortical responses. PMID- 4328501 TI - The use of diaminobenzidine (DAB) for the histochemical demonstration of cytochrome oxidase activity in unfixed plant tissues. PMID- 4328502 TI - Islet cell neoplasm in four dogs. PMID- 4328503 TI - Vertebral fracture in a horse. PMID- 4328504 TI - The nature of the acid transition of ribonuclease A. PMID- 4328505 TI - Recurrent osteomyelitis. Report of four cases culturing L-form variants of Staphylococci. PMID- 4328506 TI - Effects of neurotropic drugs on lannate and atropine toxicity in the western spruce budworm, Choristoneura occidentalis (Lepidoptera: Tortricidae). PMID- 4328507 TI - Stimulation of jejunal adenyl cyclase by ethanol. PMID- 4328508 TI - Pyruvate effect in maintenance of ATP and 2,3-DPG of stored blood. PMID- 4328509 TI - Enhancement of brain thiamine diphosphatase activity of rats by injection of cholinergic drugs. PMID- 4328510 TI - Changes in free fatty acids of brain by drug-induced convulsions, electroshock and anaesthesia. PMID- 4328511 TI - Regional distribution and rate of production of free fatty acids in rat brain. PMID- 4328512 TI - Uptake and release of 45Ca by brain microsomes, synaptosomes and synaptic vesicles. PMID- 4328513 TI - Developmental changes of DOPA decarboxylase in chick embryo and chick spinal and sympathetic ganglia. PMID- 4328514 TI - [Dosage schedule of new anticancer drugs--evaluation of the use of 3 anticancer drugs in the study of phases 1 and 2]. PMID- 4328515 TI - [Diagnostic error "eczema"]. PMID- 4328516 TI - [The so-called epitheloid cells in glomus neoplasms and arteriovenous epitheloid cell-like glomiform anastomoses. Histogenesis, ultrastructure and functional significance]. PMID- 4328517 TI - [Circulation of generally not recognized therapeutic procedures in private practice. Results of a 3d conclusive enquiry]. PMID- 4328520 TI - [Early arteriographic diagnosis of tympanic glomus tumors]. PMID- 4328519 TI - Distant effects of neoplasm on the nervous system. PMID- 4328518 TI - Sensory transmission of spinal heat and cold sensitivity in ascending spinal neurons. PMID- 4328521 TI - [Importance of cannulation of the thoracic duct for clinical use and research]. PMID- 4328522 TI - [Urogenital cancer in children]. PMID- 4328523 TI - [Retinal angioblastoma and glomus tumor (coincidence or identity?)]. PMID- 4328524 TI - Nerve conduction studies in neuropathy associated with rheumatoid arthritis and arteritis. PMID- 4328525 TI - Pigmented nodular hidradenoma. PMID- 4328526 TI - Multiple hamartomatous glomus tumors of the skin. PMID- 4328527 TI - [Efficacy of different antiphlogistic agents with respect to carrageenan inflammation, compared with other models of inflammation]. PMID- 4328528 TI - Effects of theophylline on the contractile activity of taenia coli. PMID- 4328529 TI - Action of angiotensin and plasmakinins on blood flow through the mammary artery in unanesthetized lactating goats. PMID- 4328530 TI - Contraction and relaxation of in vitro perfused rat caudal artery: a possible role for cyclic 3'-5'-AMP. PMID- 4328531 TI - [Autolytic degradation of cartilage and its pharmacological influencing]. PMID- 4328533 TI - Problems in the diagnosis and management of hepatoblastoma. PMID- 4328532 TI - Progressive multifocal leukoencephalopathy. PMID- 4328534 TI - [Action of renal phospholipids on the renin-angiotensin system of the rat]. PMID- 4328535 TI - [Action of the antidiuretic hormone (ADH) on the renin-angiotensin system of the rat]. PMID- 4328536 TI - [Influence of x-rays on the zeta potential of the cells of Yoshida ascites hepatoma]. PMID- 4328537 TI - [Effects of x-rays on the cells of ascites tumors, studied with fluorescence microscopy]. PMID- 4328538 TI - [Action of x-rays on the mucopolysaccharide content of the blood and ascitic fluid of rats with Yoshida's ascites hepatoma]. PMID- 4328539 TI - [Spinal poliomyelitis due to contact with polio vaccine virus]. PMID- 4328540 TI - [Cytomegalic inclusion disease]. PMID- 4328541 TI - [Malignant tumors of palatine tonsil]. PMID- 4328542 TI - [Several problems concerting the etiology and therapy of aplastic anemia]. PMID- 4328543 TI - [Comparative studies on the estimation method of lactic dehydrogenase in human serum]. PMID- 4328544 TI - [A case of primary orbital tumor (cylindroma orbitale)]. PMID- 4328545 TI - [Correlation between small intestine phosphatase and serum pseudocholinesterase in liver cirrhosis]. PMID- 4328547 TI - Antiviral chemotherapy. PMID- 4328549 TI - Purity of synthetic peptide preparations. PMID- 4328548 TI - C-type RNA tumour virus genome expression in wild house mice. PMID- 4328546 TI - [Importance of the sympathico-adrenal system in renin release]. PMID- 4328550 TI - [Carcino-fetal antigens in gastroenterology]. PMID- 4328551 TI - [The existence of alpha 1-fetoprotein apart from hepatoma]. PMID- 4328552 TI - [A new method of intra-arterial lipiodol hepatography]. PMID- 4328553 TI - Chemodectomas of the neck. Report of six cases with a review of the literature. PMID- 4328554 TI - [Renal metastasis from lung cancer]. PMID- 4328555 TI - [On the anterior interosseous nerve syndrome (Kiloh and Nevin)]. PMID- 4328556 TI - Ectopic alkaline phosphatase production in metastasizing ventricular carcinoma. PMID- 4328557 TI - The galactose utilization rate in liver slices from man and rat and its relation to the lactate-pyruvate ratio of the medium. PMID- 4328558 TI - Plasma corticosteroids in normal individuals with reference to the circadian rhythm, ACTH test, insulin test, and dexamethasone suppression test. PMID- 4328559 TI - Experimental swine pneumonia caused by reovirus type 3. PMID- 4328561 TI - [Diuretic effect of ACTH zinc-phosphate in patients with arteriosclerotic cardiosclerosis]. PMID- 4328560 TI - IgG-type cold agglutinins in children and corresponding antigens. Detection of a new Pr antigen: Pr a . PMID- 4328562 TI - [Direct effect of glucocorticoids on peripheral blood eosinophils]. PMID- 4328563 TI - [Treatment of juvenile chronic polyarthritis and of Still's syndrome using a new antirheumatic agent]. PMID- 4328564 TI - Effects of 3',5' cyclic nucleotides on membrane transport in isolated thyroid cells. PMID- 4328566 TI - Clonal pattern of metastasis in a case of malignant mucoepidermoid tumour of the palatal salivary gland. PMID- 4328565 TI - [Study of plasma ACTH in 100 human lysine-vasopressin tests]. PMID- 4328568 TI - [Autopsy case of malignant glioma with extreneural metastases]. PMID- 4328567 TI - [Autopsy case of insuloma-induced hypoglycemic come lasting for 365 dyys]. PMID- 4328569 TI - The Tecumseh study of respiratory illness. II. Patterns of occurrence of infection with respiratory pathogens, 1965-1969. PMID- 4328570 TI - The Tecumseh study of respiratory illness. 3. Incidence and periodicity of respiratory syncytial virus and Mycoplasma pneumoniae infections. PMID- 4328571 TI - Secretory epithelium in venom glands of two species of scorpion of the genus Centruroides Marx. PMID- 4328572 TI - [Adenovirus etiology of various cases of mesenteric lymphadonitis with appendicular syndrome]. PMID- 4328573 TI - Human cytomegalovirus complement fixation studies. PMID- 4328574 TI - [The content of serum anti-adenovirus antibodies in the healthy population]. PMID- 4328575 TI - [Immunogenic value of the diphtheria-tetanus-pertussis trivaccine depending on the quantitative variations of its antigenic components. IV. Immunogenic properties of the pertussis compound]. PMID- 4328576 TI - [Preliminary data on the purification and structure of Clostridium perfringens alpha-toxin]. PMID- 4328577 TI - Experimental adenovirus pneumonia in calves. PMID- 4328578 TI - Inactivation of infectious laryngotracheitis virus by disinfectants. PMID- 4328579 TI - [On the chronological sequence of action of some hepatic enzymes of carbohydrate and protein metabolism during the course of fasting]. PMID- 4328580 TI - [Succinate dehydrogenase activity in the cells of ascites tumors. Effect of radiations]. PMID- 4328581 TI - [Acid and alkaline phosphatase activity in the cells of ascites tumors. Effect of radiations]. PMID- 4328582 TI - [Antigens of the cells of Yoshida's ascites hepatoma demonstrated by cellular electrophoresis]. PMID- 4328584 TI - Transport of -aminoisobutyric acid in mammalian pancretic -cells. PMID- 4328585 TI - Neuronal discharges of the ventrolateral nucleus of the thalamus during sleep and wakefulness in the cat. II. Evoked activity. PMID- 4328583 TI - Adipocytes, available energy and endocrine pancreas. PMID- 4328587 TI - Plasma monoamine oxidase activity in regularly menstruating women and in amenorrheic women receiving cyclic treatment with estrogens and a progestin. PMID- 4328586 TI - Gonadal steroid sulfates and sulfatase. 3. Correlation of human testicular sulfatase, 3beta-hydroxysteroid dehydrogenase-isomerase, histologic structure and serum testosterone. PMID- 4328589 TI - Collagenolysis in cultured tissue. I. Digestion of mesenteric fibers by enzymes from explanted gingival tissue. PMID- 4328588 TI - Effects of oral contraceptive therapy on the renin-angiotensin system. PMID- 4328591 TI - Cyclic AMP and immune responses. I. Influence of poly A:U and cAMP on antibody formation in vitro. PMID- 4328590 TI - Collagenolysis in cultured tissue. II. Role of mast cells. PMID- 4328592 TI - Response of canine fetuses and neonates to antigenic stimulation. PMID- 4328594 TI - [X-ray diagnosis of breast cancer]. PMID- 4328593 TI - The oxidation and reduction of organic compounds by ionizing radiation: L penicillamine hydrochloride. PMID- 4328595 TI - [Diagnostic significance of radiologic examination in tumorous diseases of the breast]. PMID- 4328596 TI - [Combined treatment of breast cancer]. PMID- 4328597 TI - [Case of multiple primary cancer of the duodenum and transverse colon]. PMID- 4328598 TI - The inactivation of murine viral antigens with beta-propiolactone. PMID- 4328599 TI - The effect of restraint and position upon selected respiratory parameters of two species of Macaca. PMID- 4328600 TI - Spontaneous abortion in wild-caught rhesus monkeys, Macaca mulatta. PMID- 4328601 TI - An anesthetic technic for primates during emplacement of a flow sensor about the middle cerebral artery. PMID- 4328602 TI - The colony management of Marmosa mitis, the pouchless opossum. PMID- 4328603 TI - Antibodies in germfree mice against mouse viruses following exposure to infected mice. PMID- 4328604 TI - Renal concentration test in beagle dogs. PMID- 4328605 TI - Slow lactose fermenting Escherichia coli diarrhea in a group of patas monkeys (Erythrocebus patas). PMID- 4328606 TI - Electrocardiographic studies of miniature swine: normal values. PMID- 4328607 TI - The hemogram of the maternally-reared neonatal and infant baboon (Papio cynocephalus). PMID- 4328608 TI - Diabetes mellitus in a rhesus monkey (macaca mulatta): a case report and literature review. PMID- 4328609 TI - Several uncommon pituitary tumors in the rat. PMID- 4328610 TI - Ringtail in Mystromys albicaudatus: a case report. PMID- 4328611 TI - A lightweight pneumatically sealing metal door for germfree isolators. PMID- 4328614 TI - Extraction of baboon canine teeth: a simple efficient technic. PMID- 4328612 TI - A device for measuring the volume of footpad swelling from delayed hypersensitivity reactions in mice. PMID- 4328613 TI - Laparoscopic examination of the ovaries in goats and primates. PMID- 4328615 TI - Surgical technic for cross-circulation of rhesus monkeys. PMID- 4328616 TI - Peripheral blood changes in the pregnant (Kenya) baboon (Papio cynocephalus). PMID- 4328618 TI - [Significance of quantitative immunoglobulin determinations (IgM, IgA) for diagnosis and therapy of infections in the newborn period]. PMID- 4328619 TI - [EEG and sleeping behavior in newborn infants with convulsions]. PMID- 4328617 TI - [Erythrocyte enzymes in human fetuses]. PMID- 4328620 TI - [Significance of the Epstein-Barr virus in infectious mononucleosis and malignant tumors]. PMID- 4328621 TI - Lithium in psychiatry. PMID- 4328622 TI - Formation of new connexions in adult rat brains after partial deafferentation. PMID- 4328623 TI - Cell division in medium lacking serum growth factor: comparison of lines transformed by different agents. PMID- 4328624 TI - Effects of physical factors on the production of avian sarcoma virus B77 by rat tumour cells 17RB177 and clonal analysis of these cells. PMID- 4328625 TI - [Intensity of metabolism of individual fractions of growing and adult rat brain phospholipids]. PMID- 4328626 TI - [Effect of catecholamines on neuromuscular transmission]. PMID- 4328627 TI - Improved parameters of pituitary incubation for the assay of corticotrophin releasing factor. PMID- 4328628 TI - Physiological evidence for 'short-loop' feedback effects of ACTH on hypothalamic CRF. PMID- 4328629 TI - Mechanism of action of prolactin-inhibiting factor. PMID- 4328630 TI - Dissociation of changes in growth hormone and adrenocortical hormone levels during brain stimulation of monkeys. PMID- 4328631 TI - Effects of gamma-hydroxybutyrate on segmental and cortical control of transmission of the afferent volley at spinal level. PMID- 4328632 TI - The facilitatory effects of catechol and phenol at the neuromuscular junction of the cat. PMID- 4328633 TI - A barbiturate-like effect of adrenocorticotropic hormone on the partial reinforcement acquisition and extinction effects. PMID- 4328634 TI - Responses to microinjections of angiotensin into the hypothalamus of cats. PMID- 4328635 TI - Rapid eye movement density and pattern in the sleep of normal young adults. PMID- 4328636 TI - [Abnormalities of the innervation of the muscles of the thenar eminence in 2 cases of the carpal tunnel syndrome]. PMID- 4328637 TI - Fine structure of neuroblastoma--a case report. PMID- 4328638 TI - [Passage of erythromycin and ristomycin into blood, placenta, fetus and amniotic fluid during various stages of pregnancy in generalized staphylococcal infection in albino rats]. PMID- 4328639 TI - Bacteria, viruses, and mycoplasmas in acute pneumonia in adults. PMID- 4328640 TI - Sulfonylureas: effects in vivo and in vitro. PMID- 4328641 TI - Beloxamide effects on the liver ultrastructure in rats. PMID- 4328642 TI - Isolation of ferruginous bodies. PMID- 4328644 TI - [Activity of the disinfectants Gevisol and Quartasept on several pathogenic viruses]. PMID- 4328643 TI - [Epidemiological surveillance of Bordetella pertussis and parapertussis sensitivity to antibiotics]. PMID- 4328645 TI - Immunofluorescence studies on the transplantable rat tumor cells infected with Friend virus. PMID- 4328646 TI - Purification and properties of cytochrome c-550 and cytochrone c-551 derived from the facultative chemoautotroph, Thiobacillus novellus. PMID- 4328647 TI - [Routine method for the determination of organophosphorus insecticides by thin layer chromatography]. PMID- 4328648 TI - Comprehensive follow-up of carcinoma patients. PMID- 4328649 TI - [Study of olfactor sense through behaviors in rats. 1. Function of the external olfactory tract and anterior commissure]. PMID- 4328650 TI - Hepatitis-associated antigen in urban children. PMID- 4328651 TI - Type 7 adenovirus pneumonia. PMID- 4328652 TI - Neurodegenerative disorders and hyperaldosteronism. PMID- 4328653 TI - Pseudohermaphroditism, glomerulonephritis with the nephrotic syndrome, and Wilms' tumor in infancy. PMID- 4328654 TI - Hazard of chemotherapy in congenital Wilms' tumor. PMID- 4328655 TI - Erythropoietin and renin release by isolated perfused canine liver--kidney preparation. PMID- 4328656 TI - Studies on the neuropharmacology of papaverine. I. The curare-like action isolated nerve-muscle preparation. PMID- 4328657 TI - Studies on the neuropharmacology of papaverine. II. The effect on neuromuscular transmission in the whole animal. PMID- 4328658 TI - Locomotor diseases of pigs. PMID- 4328659 TI - Sarcomas of the uterus. PMID- 4328661 TI - Influence of varying calcium levels on the utilization of calcium meta- and pyrophosphate in chick diets. PMID- 4328660 TI - [Morphological and histopathogenetic differences in pulmonary silicotic granulomas induced in rats by tridimite and crystobalite]. PMID- 4328662 TI - The effect of Marek's disease virus on the erythrocyte content of chicken blood. PMID- 4328663 TI - Serum neutralizing antibodies for Rous sarcoma virus among chickens in Lebanon. PMID- 4328664 TI - Transmission of type II (Marek's) leukosis with semen from infected roosters. PMID- 4328665 TI - [Cisternoscintigraphy in the diagnosis of intracranial tumors]. PMID- 4328666 TI - Maintenance hemodialysis--a clinical review. PMID- 4328667 TI - [Peptide peptidohydrolase activity of the peripheral nerve in secondary myelinic degeneration induced with organophosphoric substances (DFP)]. PMID- 4328669 TI - [Ultrastructural localization of acid phosphatase in protoplasmatic-gemistocytic tumoral astrocytes]. PMID- 4328668 TI - [Exchange of phospholipids in membranes of the central and peripheral nerve tissue and the effect of secondary myelinic degeneration induced with organophosphoric substances]. PMID- 4328670 TI - Analyses of phospholipids, ceramides, and cerebrosides by gas chromatography and gas chromatography-mass spectrometry. PMID- 4328671 TI - Immunopathology of equine infectious anemia. PMID- 4328672 TI - Rapid clinical diagnosis of common viruses by specific cytopathic changes in unstained tissue culture roller tubes. PMID- 4328673 TI - Abortion complicated by Clostridium perfringens infection. PMID- 4328674 TI - Early repair of vesicovaginal fistula. PMID- 4328675 TI - Ovarian tumors: an extension of the Peutz-Jeghers syndrome. PMID- 4328676 TI - A neuropathy in goats caused by experimental coyotillo (Karwinskia humboldtiana) poisoning: clinical and neurophysiologic studies. PMID- 4328677 TI - Pathogenesis of Marek's disease induced in chickens by contact exposure to GA isolate. PMID- 4328678 TI - Infectious bovine rhinotracheitis virus-induced abortion: rapid diagnosis by fluorescent antibody technique. PMID- 4328679 TI - Corticosteroids in the unresponsive asthmatic patient. PMID- 4328680 TI - Surgical treatment of juvenile nasopharyngeal angiofibroma. PMID- 4328681 TI - Auditory evoked response (AER): consistency of detection in young sleeping children. PMID- 4328682 TI - Aberrant internal carotid artery presenting as a mass in the middle ear. PMID- 4328683 TI - Radiculomyopathy in a southwestern Indian due to skeletal fluorosis. PMID- 4328684 TI - Observations on the eosinophilia of certain patients with rheumatoid arthritis. PMID- 4328685 TI - Inositol phosphate phosphatases of microbiological origin. Some properties of a partially purified bacterial (Pseudomonas sp.) phytase. PMID- 4328686 TI - Inositol phosphate phosphatases of microbiological origin. Observations on the nature of the active centre of a bacterial (Pseudomonas sp.) phytase. PMID- 4328687 TI - [Dysontogenetic liver neoplasms in new-born animals]. PMID- 4328688 TI - [Pathological study of 4 cases of pineal body tumor]. PMID- 4328689 TI - Properties of a Chlamydia psittaci isolated from muskrats and snowshoe hares in Canada. PMID- 4328690 TI - The role of enterotoxin in Clostridium perfringens type A enteritis. PMID- 4328691 TI - Studies of insulin and growth hormone secretion in a subject with hepatoma and gypoglycemia. PMID- 4328692 TI - Entamoeba histolytica associated with chronic glomerulonephritis: case report. PMID- 4328693 TI - The regulation of purine utilization in bacteria. I. Purification of adenine phosphoribosyltransferase from Escherichia coli K12 and control of activity by nucleotides. PMID- 4328694 TI - The regulation of purine utilization in bacteria. II. Adenine phosphoribosyltransferase in isolated membrane preparations and its role in transport of adenine across the membrane. PMID- 4328695 TI - The regulation of purine utilization in bacteria. III. The involvement of purine phosphoribosyltransferases in the uptake of adenine and other nucleic acid precursors by intact resting cells. PMID- 4328697 TI - Drosophila beta-L-hydroxy acid dehydrogenase. Purification and properties. PMID- 4328696 TI - Sialic acids. 13. A uridine diphosphate D-galactose: mucin galactosyltransferase from porcine submaxillary gland. PMID- 4328698 TI - Interaction between adenine nucleotides and 3-phosphoglyceraldehyde dehydrogenase. I. Inhibition of the hydrolysis of S-acetyl-enzyme intermediate in the esterase activity. PMID- 4328700 TI - Selective chemical modification of malate dehydrogenase. N-ethylmaleimide modification of active center sulfhydryl residues. PMID- 4328699 TI - Interaction between adenine nucleotides and 3-phosphoglyceraldehyde dehydrogenase. II. A study of the mechanism of catalysis and metabolic control of the multi-functional enzyme. PMID- 4328701 TI - Circular dichroism of reduced and oxidized mammalian lipoamide dehydrogenase. PMID- 4328703 TI - Ultrastructure of a glomus tumour. AB - The ultrastructure of a glomus tumour is described, and the implications of the findings with regard to the histogenesis of this type of tumour are briefly discussed. PMID- 4328702 TI - Simplified organ cultures of human embryo trachea in the diagnosis of viral respiratory disease of children. AB - Organ cultures of human embryonic trachea in test tubes were used as an adjunct to tissue cultures in the isolation of respiratory viruses from children in hospital. Fifty-one viruses were obtained from 127 specimens, giving an isolation rate of 40%. Fifteen viruses were isolated from the original tissue cultures and also after passage through organ culture. Thirty viruses were isolated from the original tissue culture only, and six viruses only from organ culture (three para influenza, one influenza A, and one rhinovirus). An increase of 5% in virus isolation rate over that of standard tissue culture was obtained. PMID- 4328704 TI - Immune response to foot-and-mouth disease virus. PMID- 4328705 TI - Bovine immune response to local infections. Immunization with bovine enteroviruses and quantitative studies on bovine colostral IgG. PMID- 4328706 TI - Phosphofructokinase (PFK) regulation of glycolysis in skin. PMID- 4328707 TI - The distribution of 17 carbon fatty acids in the liver of a child with propionicacidaemia. PMID- 4328709 TI - Results of resection for bronchogenic carcinoma. PMID- 4328708 TI - Genetic variability of human plasma and erythrocyte lipids. PMID- 4328710 TI - Treatment of intractable narcolepsy with a monoamine oxidase inhibitor. PMID- 4328711 TI - "I-cell" disease: leakage of lysosomal enzymes into extracellular fluids. PMID- 4328712 TI - Effects of angiotensin on blood pressure and renal function in pregnant and non pregnant rats. PMID- 4328713 TI - Some important teat diseases of dairy cattle. PMID- 4328714 TI - Isolation of Parainfluenza type 5 virus from sheep in New Zealand. PMID- 4328715 TI - Murine lymphoma induced by reovirus 3. PMID- 4328716 TI - Inhibition by chloramphenicol of aminoazo dye carcinogenesis in rat liver: morphological studies. PMID- 4328718 TI - Atypical pyruvate kinase in a patient with haemolytic anaemia. PMID- 4328717 TI - [Extra-adrenal nonchromaffin hormono-active and inactive paraganglioma]. PMID- 4328719 TI - [Biochemistry and medicine]. PMID- 4328720 TI - [Specificity and practical use of aimed neutralization test in the diagnosis of enterovirus diseases]. PMID- 4328721 TI - Mechanism of noradrenaline hyperpolarization in spinal cord motoneurones of the cat. PMID- 4328722 TI - Preservation of some histochemically demonstrable enzyme activities in polyethyleneglycol-embedded liver tissue during prolonged storage. PMID- 4328723 TI - [Para-sleep and EEG of the amygdaloid body in cats--preliminary report]. PMID- 4328724 TI - [Skin potential activities and the degree of awakening]. PMID- 4328726 TI - Uterine leiomyoma containing metastatic breast carcinoma. PMID- 4328727 TI - Inhibition by cycloheximide of ACTH-induced internal differentiation of mitochondria in cortical cells in tissue cultures of fetal rat adrenals. PMID- 4328728 TI - Immunologic response in patients to cells of their own tumor. PMID- 4328729 TI - A survey of sheep throughout Australia for antibody to parainfluenza type 3 virus and to mucosal disease virus. PMID- 4328730 TI - Allosteric interactions in phosphorylase B. PMID- 4328731 TI - E Pluribus Unum: Presidential address. PMID- 4328732 TI - Hormonal effects on thymidine kinase activity in normal rat adrenal and in hormone-dependent adrenal carcinoma. PMID- 4328733 TI - DNA synthesis and the effect of sucrose in nuclei of host liver and Morris hepatomas. PMID- 4328734 TI - Regulation of the rate of sterol synthesis and the level of beta-hydroxy-beta methylglutaryl coenzyme A reductase activity in mouse liver and hepatomas. PMID- 4328735 TI - A comparative study of some of the enzymes involved in glucose metabolism of human diploid and SV40-transformed human diploid cells. PMID- 4328736 TI - Carcinogenicity testing of N-hydroxy and other oxidation and decomposition products of 1- and 2-naphthylamine. PMID- 4328737 TI - Strain specificity in mouse mammary tumor virus virion antigens. PMID- 4328738 TI - Histology and ultrastructure of cultured human tumor cells exposed to antisera to the nerve growth factor. PMID- 4328739 TI - Reduction and enhancement by phenobarbital of hepatocarcinogenesis induced in the rat by 2-acetylaminofluorene. PMID- 4328740 TI - Improved method for measurement of delta-aminolevulinic acid dehydratase activity of human erythrocytes. PMID- 4328741 TI - Biochemistry of snake venoms. PMID- 4328742 TI - Elapid neurotoxins and their mode of action. PMID- 4328743 TI - Learning deficits and activity changes: a partial laboratory model in postencephalitic rats for studies of brain damage. PMID- 4328744 TI - [Gynecologic space as an intrusion field. Neural therapeutic observation]. PMID- 4328745 TI - [Homosynaptic depression and presynaptic inhibition of the N-I component of the dorsal surface potential in the spinal cord of rats with extracerebral neoplasms]. PMID- 4328746 TI - [Effect of biophysical factors on the redox processes and biological oxydation. XII. Ultrasound effect on the cytochrome oxidase activity]. PMID- 4328747 TI - Neurosecretion in the brain of a scorpion Heterometrus swammerdami--a histochemical study. PMID- 4328748 TI - [Further experimental studies on the mechanism of action of neurohormone D from Periplaneta americana (L) on the "biologic model" of Bufo bufo urinary bladder: influencing of Na+-transport]. PMID- 4328750 TI - Self-care taught in hospital apartments. PMID- 4328749 TI - [Viruses against neoplasms]. PMID- 4328751 TI - The group psychotherapy literature 1970. PMID- 4328752 TI - Asymmetric template function of microbial deoxyribonucleic acids: transcription of messenger ribonucleic acid. AB - In Bacillus subtilis and Escherichia coli, pulse-labeled ribonucleic acid (RNA) synthesized during step-down growth hybridized preferentially with the heavy (H) strand of methylated albumin-Kieselguhr-fractionated deoxyribonucleic acid (DNA). At high RNA inputs, the ratio of RNA hybridized with the H strand to that hybridized with the light (L) strand was 8.7 for B. subtilis and 2.0 for E. coli. At high DNA inputs, the H/L hybridization ratio increased by a factor of two. This change in the hybridization ratio was attributable to the fraction of the pulse-labeled RNA which is in stable RNA components. The hybridization peak of pulse-labeled RNA was specifically located in the late-eluting region of the absorbance profile of the H strand. This region was considered to represent the most actively transcribing H strand templates. PMID- 4328753 TI - Properties of nonheme iron in a cell envelope fraction from Escherichia coli. AB - The reaction with o-phenanthroline of nonheme iron found in cell envelope fractions from Escherichia coli has been investigated. About 20% of the total nonheme iron reacts directly with o-phenanthroline. This iron appears to be in the ferric state but is reducible by protein sulfhydryl groups in the presence of the chelating agent. A further 20% of the nonheme iron will react with o phenanthroline only in the presence of dithionite. Succinate can replace dithionite but only produces about 35% of the reaction given by dithionite. The reduction of cytochrome b(1) of the respiratory chain by succinate shows similar behavior to the reaction of iron with o-phenanthroline in the presence of succinate. Both of these components react completely only in the presence of 2 heptyl-4-hydroxyquinoline-N-oxide. The remaining 60% of the nonheme iron of the cell envelope will not react with o-phenanthroline even in the presence of dithionite or 6 m urea. Triton X-100 with dithionite will permit a small part (10%) of this iron to react with o-phenanthroline. The iron which does not react with o-phenanthroline is not associated with succinate, reduced nicotinamide adenine dinucleotide, or d-lactate dehydrogenases. PMID- 4328754 TI - Biochemical characterization of a mutant isoleucyl-transfer ribonucleic acid synthetase from Escherichia coli K-12. AB - Isoleucyl-transfer ribonucleic acid (tRNA) synthetase [l-isoleucine: soluble RNA ligase (adenosine monophosphate), EC 6.1.1.5; IRS] was partially purified from Escherichia coli K-12 and from an ileS mutant that appears to be altered in IRS. The half-life of wild-type IRS, incubated at 60.5 C, is 69 min, whereas that of mutant IRS is 8 min. Mutant IRS shows about a 100-fold lower affinity than wild type IRS for isoleucine, dl-valine, thiaisoleucine, and O-methyl-dl-threonine, both in the pyrophosphate exchange assay and in the assay of isoleucyl-tRNA formation. The affinity of the mutant enzyme for adenosine triphosphate in the assay of isoleucyl-tRNA formation is 15-fold lower than that of the wild-type enzyme. The affinity of mutant IRS for tRNA is not changed as compared with wild type IRS. These data show that mutant IRS has an altered structure and clearly confirm that ileS is the structural gene for IRS. PMID- 4328756 TI - Biochemistry of Coxiella burnetii: Embden-Meyerhof pathway. AB - Purified preparations of Coxiella burnetii were examined for enzymes of the glycolytic pathway. Glucose-phosphate isomerase, fructose-1,6-diphosphatase, aldolase, glyceraldehyde-3-phosphate dehydrogenase, and pyruvate kinase were shown to be present in C. burnetii extracts. Heat-killed C. burnetii purified with normal yolk sacs demonstrated no activity after disruption. Aldolase was shown to be of the class II type by complete inhibition of activity in the presence of 8 x 10(-3)m ethylenediaminetetraacetic acid. The host enzyme activity (normal and infected yolk sacs) was not affected by the same treatment. When cellulose acetate electrophoresis was performed on the extracts, aldolase from both normal and infected yolk sacs exhibited five isozyme bands, whereas aldolase from the C. burnetii extract appeared as a single band. PMID- 4328757 TI - Respiratory activity of mitochondria from isolated human and dog hearts maintained in a portable preservation chamber. PMID- 4328755 TI - Mode of action of a bacteriocin from Serratia marcescens. AB - The effects of bacteriocin JF246, produced by Serratia marcescens, on the incorporation of labeled leucine and thymidine, the synthesis of beta galactosidase, the active transport of labeled leucine and alpha-methyl-d glucoside, and the cellular levels of adenosine triphosphate (ATP) in Escherichia coli were studied. This bacteriocin strongly inhibited the incorporation of leucine and thymidine into protein and deoxyribonucleic acid, respectively, as well as the active transport of leucine. The accumulation of alpha-methyl-d glucoside, which is mediated by a phosphoenolpyruvate-dependent phosphotransferase system, was not markedly inhibited. The level of ATP in bacteriocin-treated cells rapidly fell to 10 to 15% of the control value. However, the kinetics of inhibition of macromolecular synthesis by various levels of bacteriocin was not related to the kinetics of ATP decline. PMID- 4328758 TI - Effects of glucagon on adenyl cyclase activity in the left and right ventricles and liver in experimentally-produced isolated right ventricular failure. PMID- 4328760 TI - Experimental viral-induced congenital encephalopathies. II. The pathogenesis of bluetongue vaccine virus infection in fetal lambs. PMID- 4328761 TI - [Electrosleep and its use in surgery]. PMID- 4328759 TI - [Prostaglandins]. PMID- 4328762 TI - Biochemical evidence of adrenergic interaction with cholinergic function in the central nervous system of the rat. 1. Effect of norepinephrine. PMID- 4328763 TI - Effects of temporary tourniquet ischemia on striated muscle fibers and motor end plates. Morphological and histochemical studies in the rabbit and electromyographical studies in man. PMID- 4328764 TI - Treatment of the alkali-burned cornea. PMID- 4328765 TI - A rare smallpox-like disease. PMID- 4328766 TI - [Introduction to the studies on slow virus infections and the nervous system]. PMID- 4328767 TI - [Neuropathology of cytomegalovirus infection]. PMID- 4328768 TI - [Sero-epidemiological study on cytomegalovirus infections in children with special reference to the mentally retarded]. PMID- 4328769 TI - [Brain diseases in man and virions--capsomer count of PML (progressive multifocal leukoencephalopathy) virions]. PMID- 4328770 TI - [Virus-induced experimental brain tumors]. PMID- 4328772 TI - Implication of organophosphate pesticide poisoning in the plane crash of a duster pilot. PMID- 4328771 TI - Morphological and cytochemical studies of hypokinetic effects. PMID- 4328773 TI - Total dust, coal, free silica, and trace metal concentrations in bituminous coal miners' lungs. PMID- 4328774 TI - Study of silicosis in Peruvian mines and permissible dust concentrations. PMID- 4328775 TI - Plasma testosterone stimulation-suppression dynamics in hirsute women. PMID- 4328776 TI - The metabolic effects of nonvolatile anesthetics on mammalian hepatoma cells in vitro. II. Inhibition of macromolecular precursor incorporation. PMID- 4328777 TI - Brain stem arteriovenous malformations. PMID- 4328778 TI - Collagenase activity of intact corneal epithelium in peripheral alkali burns. PMID- 4328779 TI - Testicular adenyl cyclase: stimulation by the pituitary gonadotrophins. PMID- 4328780 TI - Bull seminal plasma and the regulation of 17-beta-estradiol dehydrogenase activity in spermatozoa. PMID- 4328781 TI - Effect of cyanoketone, an inhibitor of delta-5-3-beta-hydroxysteroid dehydrogenase, on the reproductive tracts of male fetal rats, in organ culture. PMID- 4328782 TI - The response of idiopathic retroperitoneal fibrosis to corticosteroids. PMID- 4328783 TI - Hydropathy in America: a nineteenth century panacea. PMID- 4328784 TI - Radioimmunoassay of hormones and a critical review of its application to angiotensin assay. PMID- 4328785 TI - Enteroviruses: vaccines, epidemiology, diagnosis, classification. PMID- 4328786 TI - [Relationship between the renin-angiotensin-aldosterone system and CNS in the etiology of hypertension]. PMID- 4328787 TI - [Morphologic spectrum of primary and secondary liver tumors in children]. PMID- 4328788 TI - Regeneration in botulinum-poisoned forelimbs of the newt, Triturus. PMID- 4328789 TI - Compression neuritis of the ulnar nerve at the elbow. PMID- 4328790 TI - An unusual cause of ulnar nerve compression. PMID- 4328791 TI - Ulnar nerve compression lesions at the wrist and hand. PMID- 4328792 TI - An investigation of the factors affecting the results of digital nerve division. PMID- 4328793 TI - Lobster-claw deformities of the hand. PMID- 4328794 TI - The association of viruses with clinical pertussis. AB - This study describes the results of attempts to grow viruses from per-nasal swabs taken from 136 children with clinical pertussis.Altogether 37 strains of a variety of different viruses were isolated. Adenovirus was the most frequent, making up 30% of the total. Besides these, herpes simplex, measles, influenza A2, influenza B, mumps, poliovirus and respiratory syncytial virus were detected.Bordetella pertussis was isolated from 22% of the cases.It appears that a pertussis-like syndrome can be caused by many agents besides Bord. pertussis and an accurate diagnosis requires laboratory confirmation. PMID- 4328795 TI - Postnatal decline of maternally acquired viral antibodies of different specificities. AB - The rates of decline (half-lives) of maternally acquired antibodies of two different specificities in a group of infants were found to be highly variable, ranging from 18 to 192 days for parainfluenza type 3 antibody (54 infants) and from 15 to 251 days for influenza A2 antibody (nine infants). For antibodies of both specificities approximately 75% of the half-lives were between 15 and 60 days. With parainfluenza type 3 antibody, and possibly with influenza A2 antibody, the half-lives were inversely proportional to the initial antibody titre of the babies' sera. This relationship could be described by a rectangular hyperbola. Babies with high antibody titres at birth lost this antibody rapidly whereas in babies with low initial titres antibody declined over a longer period.The half-lives of parainfluenza type 3 antibody and influenza A2 antibody were compared with that of rubella antibody in the same group of infants (previously published). Maternally acquired viral antibodies of different specificities did not necessarily decline at similar rates in any given child. In nine infants, maternally acquired antibodies of two different specificities (rubella and parainfluenza type 3) declined at significantly different rates in the same child. It is suggested that although the half-life of antibody of a given specificity is related to its concentration in the serum, it is independent of the level of serum antibodies of other specificities. PMID- 4328796 TI - Sero-epidemiological survey on Yaba and 1211 virus infections among several species of monkeys. AB - The distribution of neutralizing antibody to Yaba virus and 1211 agent in the sera of three Asian and one African monkey species was examined.Cynomolgus (Macaca irus), bonnet (M. radiata) and rhesus (M. mulatta) monkeys possessed antibody to Yaba virus at incidences of 19.9, 8.4 and 0%, respectively. In African green monkeys (Cercopithecus aethiops) the incidence was as high as 76.4%.As for 1211 agent, no Asian monkeys had neutralizing antibody and 5.5% of African green monkey sera neutralized the virus. PMID- 4328797 TI - Mechanisms of neuropathy. PMID- 4328798 TI - Detection of Epstein-Barr viral genome in nonproductive cells. PMID- 4328800 TI - New step in transmitter release at the myoneural junction. PMID- 4328799 TI - Effect of the thiol-oxidizing agent, diamide, on acetylcholine release at the frog endplate. PMID- 4328801 TI - Host-cell repair of vaccinia virus and of double stranded RNA of encephalomyocarditis virus. PMID- 4328802 TI - Umbilical cord leucocytes transformed by lymphoid cell filtrates from healthy people. PMID- 4328803 TI - Inhibition by papaverine of 3',5'-nucleotide-phosphodiesterase (E.C.3.1.4.1.) from bovine uterus muscle. PMID- 4328804 TI - Effect of REM sleep deprivation on retention of a one-trial passive avoidance response. PMID- 4328805 TI - [Comparative studies of the effect of ACTH prolongatum Polfa and corticotropin Organon on the function of the adrenal cortex]. PMID- 4328806 TI - The resistance to Marek's disease of chicks from immunized breeders. PMID- 4328807 TI - Effect of infectious agents on chickens selected for plasma corticosterone response to social stress. PMID- 4328808 TI - Prostaglandins. PMID- 4328809 TI - Indications for orthotopic liver transplantation: with particular reference to hepatomas, biliary atresia, cirrhosis, Wilson's disease and serum hepatitis. PMID- 4328810 TI - Observations on prolonged immune suppression for human liver homografts. PMID- 4328811 TI - Detection of antigens of the mouse mammary tumor (MTV) and murine leukemia virus (MuLV) in cells of cultures derived from mammary tumors of mice of several strains. PMID- 4328812 TI - The heritable nature of the factor in chicken cells which acts as a helper virus for Rous sarcoma virus. PMID- 4328813 TI - The identification of the 3'-hydroxyl nucleoside terminus of avian myeloblastosis virus RNA. PMID- 4328815 TI - [Action of a benzodiazepine derivative, Ro 5-4200, on the EEG and sleep cycle of patients with insomnia]. PMID- 4328814 TI - Multiplicity reactivation of human adenovirus type 12 and simian virus 40 irradiated by ultraviolet light. PMID- 4328816 TI - [Malignant change of genital Paget's disease: report of a case]. PMID- 4328817 TI - [The relations between progressive scleroderma and malignant tumours]. PMID- 4328818 TI - [Optic tract compression in intracranial supratentorial pressure increase]. PMID- 4328820 TI - The toxicity of organophosphorus compounds to mammals. AB - The acute toxicity of most of the commonly used organophosphorus insecticides is essentially the same. A few compounds with low toxicity, such as malathion, have been developed but further efforts in that direction are needed. Most of the organophosphorus insecticides exert a generalized cholinergic action by inhibiting central and peripheral cholinesterases. The phosphoramides are an exception in that they do not gain access to the cholinesterase of the central nervous system in vivo and consequently atropine is a more effective antidote for them than for organophosphorus compounds. Young animals are more susceptible to the organophosphorus compounds than are adults. Enzyme-inducing agents decrease the toxicity of the phosphorothioates and phosphorodithioates. All organophosphorus insecticides can inhibit esterases that catalyse the detoxification of some insecticides of this class and ester-type drugs. PMID- 4328821 TI - Aspects of research on insect growth hormones. AB - Current research on insect growth hormones includes studies on the binding of hormones to receptor molecules, probably proteins. Evidence has been obtained that this process does in fact occur and may be the means whereby the hormones "recognize" target tissues. Other studies on the possibility of a feedback effect when growth hormones are used for insect control suggest that there is a positive feedback relationship between the hormone titre and the activity of prothoracic glands and corpora allata, but the details are not yet clear. Cyclic adenosine 3',5'-monophosphate has an important role as "second messenger" in vertebrate endocrinology and may also be important in insects. Studies have shown that adenyl cyclase is present in pupal epidermis and the preliminary results have shown that it can be stimulated by a steroid hormone. PMID- 4328819 TI - Comparative metabolism and selectivity of organophosphate and carbamate insecticides. AB - The comparative metabolism and toxicity of organophosphorus and carbamate insecticides are reviewed with the purpose of assessing our present ability to design new toxicants with improved selectivity. The occurrence of quantitative and qualitative differences in metabolism in vertebrates and insects is considered and an assessment is made of the role of metabolic activation and degradation in the complex interactions governing toxicity. PMID- 4328822 TI - Modification of the effect of vitamin A acid on the skin tumor keratoacanthoma by applications of actinomcin D. PMID- 4328823 TI - Isozymes in cancer. PMID- 4328824 TI - [Bilateral kidney tumors in children]. PMID- 4328825 TI - Linitis plastica carcinoma of the colon: report of a case. PMID- 4328826 TI - Hydrolysis of (Asn 1 , Val 5 )--angiotensin II by kidney aminopeptidases. PMID- 4328827 TI - [Histochemical studies of the effect of Meritschleri mineral water on the activity of lipase, cytochrome oxidase and adenosine triphosphatase enzymes in the liver in experimental hepatitis]. PMID- 4328828 TI - [Modification of an essential arginine residue in lactate dehydrogenase with phenylglyoxal]. PMID- 4328829 TI - Hormonal regulation of protein kinases and adenosine 3',5'-monophosphate-binding protein in developing mammary gland. PMID- 4328830 TI - The structure of Aerobacter aerogenes capsular polysaccharide. PMID- 4328831 TI - The pathway of myo-inositol degradation in Aerobacter aerogenes. Identification of the intermediate 2-deoxy-5-keto-D-gluconic acid. PMID- 4328833 TI - Reversible inactivation of rabbit liver fructose 1,6-diphosphatase by adenosine triphosphate and adenosine diphosphate. PMID- 4328832 TI - The pathway of myo-inositol degradation in Aerobacter aerogenes. Conversion of 2 deoxy-5-keto-D-gluconic acid to glycolytic intermediates. PMID- 4328834 TI - Regulation of phosphorylase activation in skeletal muscle in vivo. PMID- 4328835 TI - 25-Hydroxydihydrotachysterol 3 . Biosynthesis in vivo and in vitro. PMID- 4328836 TI - Human phosphoribosylpyrophosphate synthetase. Distribution, purification, and properties. PMID- 4328837 TI - Localization of the retinol-dependent fucose-glycopeptide in the goblet cell of the rat small intestine. PMID- 4328838 TI - A revised structure for the Forssman glycolipid hapten. PMID- 4328839 TI - Adenyl cyclase in normal and transformed fibroblasts in tissue culture. Activation by prostaglandins. PMID- 4328840 TI - The mechanism of aconitase action. II. Magnetic resonance studies of the complexes of enzyme, manganese(II), iron(II), and substrates. PMID- 4328841 TI - Multiple specific hormone receptors in the adenylate cyclase of an adrenocortical carcinoma. PMID- 4328842 TI - Loss of hydrogen from dihydroxyacetone phosphate during glyceryl ether synthesis. PMID- 4328843 TI - On the equilibrium of the adenylate cyclase reaction. PMID- 4328844 TI - Analysis of steroid mixtures by column chromatography with continuous monitoring of the eluate by a flame ionisation detector. PMID- 4328845 TI - Effects of some antibiotics on the milk phosphatase pasteurization test. PMID- 4328847 TI - Long-acting phenothiazine injections given by psychiatric nurses in the community. PMID- 4328846 TI - Metabolic responses of chicks during adaptation to a high protein, "carbohydrate free" diet. PMID- 4328848 TI - [A case of mental disorder suspected to be due to the disturbance of vasomotor nerves]. PMID- 4328849 TI - Comparison of the parameters of the evoked muscle potential with motor conduction velocity and severity of neuropathy. PMID- 4328851 TI - Antibiotic therapy of infections of the lower respiratory tract. PMID- 4328850 TI - Pelvic pain, gynecic and nongynecic: interpretation and management. PMID- 4328852 TI - Piperazine estrone sulfate and conjugated estrogens equine in the treatment of the menopausal syndrome. PMID- 4328853 TI - Forty year experience with carcinoma of the male breast. PMID- 4328854 TI - Carcinoma of the breast and ovary in three families. PMID- 4328855 TI - [Radioimmunoassay of angiotensin. II. Influence of incubation conditions on precision and reproductibility of the method]. PMID- 4328856 TI - [Vitamin D metabolism in experimental uremia]. PMID- 4328857 TI - Isolation and characterization of sympathetic nerve trunk vesicles. PMID- 4328860 TI - Herpes simplex virus and cancer of the cervix. PMID- 4328859 TI - Dietary calcium-phosphorus ratios for growing pigs in relation to serum levels and bone development. PMID- 4328861 TI - Experimental feline herpesvirus infection in the pregnant cat. AB - Intravenous inoculation of pregnant cats with feline herpesvirus produced minimal illness but resulted in abortion, intrauterine fetal death and congenital fetal infection. Placental lesions included multiple infarcts in the placental labyrinth, thrombosis of maternal vessels in the endometrium and placenta, and multifocal necrosis of the giant-cell trophoblast and endometrial epithelium in the junctional zone of the placenta associated with eosinophilic intranuclear inclusion bodies. The virus was isolated from all the placentas and uteri but from none of the fetuses aborted 6-9 days after maternal intravenous inoculation. Viral antigen was demonstrated in the uterine vessels and in the junctional zone of the placenta at this time. On postinoculation day 26, viral antigen was demonstrated in the chorioallantoic membrane on the fetal side of the placenta and in the liver of a congenitally infected fetus. Although all 4 pregnant cats inoculated intranasally with feline herpesvirus aborted, neither virus, viral antigen nor significant lesions were detected in the uteri, placentas or fetuses. Abortion after intranasal inoculation was interpreted as a nonspecific reaction secondary to the severe, debilitating upper respiratory disease that occurred. PMID- 4328863 TI - Acute intestinal amoebiasis--proctoscopic appearances with histopathological correlation. PMID- 4328862 TI - Granular cell myoblastoma. An electron microscopic and cytochemical study illustrating the genesis of granules and aging of myoblastoma cells. AB - Seven typical granular cell myoblastomas, 4 from the skin (2 multicentric) and 1 each from the tongue, vulva and breast, were studied with the electron microscope and with cytochemical procedures for the visualization of lysosomes, endoplasmic reticulum, mitochondria, Golgi apparatus and membranes. With these parameters, all of the lesions were found to be virtually identical. To the authors' knowledge, the apparent formation of the specific small granule from the Golgi apparatus and the large granule (cytolysome) by segregation of portions of cell cytoplasm as well as the apparent aging process in myoblastoma cells is described for the first time. The small granules resemble lysosomes, but do not stain with the lysosomal markers employed. The large granules (cytolysomes) contain acid phosphatase but only a few contain thiolacetic acid esterase activity, suggesting that there are at least two varieties of cytolysomes in myoblastoma. It is concluded that myoblastoma is a tumor-like lesion of Schwann cell origin, which is either a reactive cellular response or, more likely, a true neoplasm. PMID- 4328864 TI - Effect of soy proteins on the growth of Clostridium perfringens. AB - Proteins that are used to fabricate imitation foods such as synthetic meats were evaluated for stimulative or inhibitory effects on the growth of Clostridium perfringens. Growth rate and extent were measured in thioglycolate medium without dextrose. This liquid medium contains Trypticase (BBL) which served as the protein control. For comparison, various soy proteins, synthetic meats, beef, turkey, sodium caseinate, and combinations of each were substituted for Trypticase. Meat loaf systems were also employed to determine the effects of protein additives to meat under actual meat loaf conditions. Growth of C. perfringens type A, strain S40, was measured in the respective media at 45 C at a pH of 7.0 and an E(h) of below -300 mv. Viable populations were enumerated by agar plate techniques on Trypticase-sulfite-yeast-citrate-agar incubated anaerobically (90% N(2)-10% CO(2)) for 18 hr at 35 C. When compared to Trypticase, some soy proteins had stimulative effects on the growth of C. perfringens, whereas sodium caseinate and some soy proteins were inhibitory. In liquid medium in which meat or soy meat was the source of protein, there was a marked stimulation by beef, chicken, and soy beef. Soy chicken supported growth at a rate less than observed with Trypticase. Under actual meat loaf conditions, the addition of soy meat or protein additives to beef did not affect the growth of C. perfringens. The addition of protein additives to turkey meat loaves significantly enhanced the rate of growth of C. perfringens. The stimulative effects of some soy proteins are significant in relation to control of foodborne disease. PMID- 4328865 TI - Regulation of staphylococcal enterotoxin B: effect of thiamine starvation. AB - During the transition between the exponential and stationary phases of growth, there was a rapid accumulation of both cell-associated and extracellular enterotoxin B. Extracellular enterotoxin was synthesized until the cells entered the stationary phase during which cell-bound toxin was not detected. The differential rate of toxin synthesis relative to that of total protein synthesis was greater at pH 7.7 than at 6.0. Addition of glucose decreased the differential rate of toxin synthesis. This decrease was greater at pH 7.7 than at 6.0. Addition of pyruvate decreased the differential rate at pH 7.7 but not at 6.0. Analysis of the nongaseous end products of glucose and pyruvate metabolism showed that conditions which favor the oxidative decarboxylation of pyruvate also favor the repression of toxin synthesis. Elimination of thiamine from the medium prevented the oxidative decarboxylation of pyruvate by Staphylococcus aureus S-6 and partially or completely reversed the repression of toxin synthesis by glucose and pyruvate. In the absence of an added energy source, thiamine starvation caused a decrease in protein synthesis but an increased differential rate of toxin synthesis which was greater at pH 7.7 than at 6.0. In the absence of thiamine, pyruvate was not metabolized but caused a decrease in the rate of protein synthesis. This resulted in a twofold increase in the differential rate of toxin synthesis. Thus, conditions which altered the oxidative decarboxylation of pyruvate or decreased the rate of protein synthesis increased the rate of enterotoxin B synthesis. PMID- 4328866 TI - Evidence for a cellular ribonucleic acid synthesis inhibitor from poliovirus infected HeLa cells. PMID- 4328867 TI - Reaction of pseudouridine and inosine with N-cyclohexyl-N'-beta-(4 methylmorpholinium)ethylcarbodiimide. PMID- 4328868 TI - Gold (III) complexes of adenine nucleotides. PMID- 4328869 TI - Mechanism of nicotinamide-adenine dinucleotide binding to rabbit muscle glyceraldehyde 3-phosphate dehydrogenase. PMID- 4328870 TI - Steroidogenic and lipolytic activities of 8-substituted derivatives of cyclic 3',5'-adenosine monophosphate. PMID- 4328871 TI - Modified blepharoplasty for malignant lid tumours. PMID- 4328872 TI - The role of cortisone and its derivatives in corneal graft rejection. PMID- 4328873 TI - The metabolism of p-fluorobenzoic acid by a Pseudomonas sp. PMID- 4328874 TI - Localization of L-asparaginase in Pseudomonas aeruginosa. PMID- 4328875 TI - The acetylene reduction assay for measuring nitrogen fixation in waterlogged soil. PMID- 4328876 TI - The amino acid source of HCN in cultures of a psychrophilic basidiomycete. PMID- 4328877 TI - Emesis and diarrhea induced by enterotoxin of Clostridium perfringens type A in monkeys. PMID- 4328878 TI - Cutaneous skin test for delayed hypersensitivity in hamsters to viral induced tumor antigens. PMID- 4328879 TI - Serum phospholipids in neoplastic disorders. PMID- 4328880 TI - Quantitative fluorimetric determination of urinary dopa and its significance for the diagnosis of neural crest tumours. PMID- 4328881 TI - Cortical responses of awake cat to narrow-band FM noise stimuli. PMID- 4328882 TI - Abnormal membrane sodium transport in Liddle's syndrome. AB - We have documented the presence of abnormal sodium transport in Liddle's syndrome by measuring sodium concentration, sodium influx, and fractional sodium outflux in vitro in erythrocytes from normal subjects, two patients with Liddle's syndrome, and one patient with primary hyperaldosteronism. Sodium influx and fractional sodium outflux, but not sodium concentration, were significantly increased in patients with Liddle's syndrome. Sodium outflux in a patient with primary hyperaldosteronism did not differ significantly from normal. These alterations of sodium transport in erythrocytes from patients with Liddle's syndrome were not attributable to circulating levels of aldosterone, renin, angiotensin, or serum potassium. Furthermore, changes in aldosterone secretory rate and levels of circulating renin produced by varying dietary sodium intake, did not alter sodium influx or fractional sodium outflux in either patients with Liddle's syndrome or normal subjects. The response of fractional sodium outflux and sodium influx to ouabain, ethacrynic acid, and to changes in the cation composition of the incubation medium suggests that the increased sodium fluxes in Liddle's syndrome do not result solely from a quantitative increase in those components of sodium transport which occur in normal human erythrocytes. Instead, at least a portion of the increased erythrocyte sodium transport in Liddle's syndrome represents a component of sodium transport which does not occur in normal human erythrocytes. PMID- 4328883 TI - Mental retardation, unusual facies, and abnormal nails associated with a group-G ring chromosome. A case report on two unrelated cases. PMID- 4328884 TI - An investigation of experimental myasthenia gravis. AB - Guinea-pigs were immunized with antigen prepared from calf thymus and muscle, and from guinea-pig thymus, and rats were immunized with antigen prepared from rat thymus and rat muscle. There was an increased incidence of delayed hypersensitivity and circulating thymus antibodies in the immunized guinea-pigs and an increased incidence of thymitis in the immunized guinea-pigs and rats. However, when compared with control animals, there was no electrophysiological evidence of impairment of neuromuscular transmission in the immunized animals. PMID- 4328886 TI - Invasion of cranial nerves by salivary cylindroma: four cases treated by radiotherapy. AB - Four cases of adenoid cystic carcinoma (cylindroma) of accessory salivary tissue are described, and the diagnostic difficulties experienced are emphasized. The tumour infiltrates cranial and other nerves and may invade the central nervous system by this route. It is highly malignant and may metastasize widely both by haematogenous and lymphatic pathways. The tumour is radiosensitive and it is suggested that the treatment of choice is radiotherapy combined, when possible, with surgical excision of the primary lesion. Metastases should be treated with radiotherapy since useful remission may occur. PMID- 4328885 TI - Motor and sensory nerve conduction velocity in the baboon: normal values and changes during acrylamide neuropathy. AB - Nerve conduction velocity and the amplitude of nerve and muscle action potentials have been measured in the median and anterior tibial nerves of normal adult and infant baboons. The effect of altered temperature on velocity has also been investigated. Seven adult baboons were intoxicated with acrylamide. In animals given 10-15 mg/kg/day, the gradual development of a peripheral neuropathy was accompanied by a decline in the amplitude of both muscle and nerve action potentials. There was also a gradual fall in conduction velocity. In some cases maximal motor velocity in the median nerve fell by as much as 34%, and in the anterior tibial nerve by as much as 49%, the largest falls being seen in animals showing the greatest reductions in response amplitude. Histological studies, reported elsewhere, have shown that the main pathological change in our animals was a degeneration of the peripheral nerves, with little demyelination. Fibre diameter histograms indicated that large fibres were particularly severely affected, and it seems likely that the reduced maximal conduction velocities were due to this selective loss of large-diameter fibres. PMID- 4328887 TI - Blockade of the effects of angiotensin, oxytocin, norepinephrine, 5 hydroxytryptamine and acetylcholine by guancydine. PMID- 4328888 TI - Erythroblastosis and theca lutein cysts. Report of a case. PMID- 4328889 TI - Genital herpes virus findings in relation to cervical neoplasia. PMID- 4328890 TI - Incorporation of P 32 orthophosphate into phospholipid of epiphyseal cartilage. PMID- 4328891 TI - Characteristics of fatty acid esterification by homogenates of bovine mammary tissue. PMID- 4328892 TI - Experiences in laboratory diagnosis of respiratory syncytial virus infections in routine medical practice. PMID- 4328894 TI - Drugs and sleep. PMID- 4328893 TI - Tests of adrenocortical function. PMID- 4328895 TI - [Ribonculeoproteins and sulfur-containing proteins in the adrenal medulla under conditions of ACTH stimulation]. PMID- 4328896 TI - [The functional state of the adrenal cortex in aging]. PMID- 4328897 TI - [The effect of ACTH, and the thyrotropic and melanocyte stimulating hormones of the hypophysis on redox processes in various rat organs and tissues]. PMID- 4328898 TI - [The significance of the adrenal glands in oxygen tension changes in tissue during hypoxia]. PMID- 4328899 TI - [Corticosteroid biosynthesis in the capsular and decapsulated portions of the rat adrenal glands, Aldosterone precursors and differences in the effect of ACTH on the zonae]. PMID- 4328900 TI - [On an atypical form of the Krukenberg tumor. (Clinical case)]. PMID- 4328901 TI - Applications of radioimmunoassay to problems of clinical interest. Sampling of some physiologic applications and diagnostic uses of radioimmunoassay indicates potentialities of method. PMID- 4328902 TI - [Case of co-existing duodenal leiomyosarcoma and stomach cancer]. PMID- 4328903 TI - Field trials with an attenuated Marek's disease vaccine. PMID- 4328904 TI - [Efficiency, dose relation and depot effect of a synthetic polypeptide with ACTH action]. PMID- 4328905 TI - [Infantile myoclonic encephalopathy]. PMID- 4328906 TI - The nature of the intestinal epithelial barrier. PMID- 4328908 TI - Uncommon roentgenologic manifestation of pancreatic carcinoma. PMID- 4328907 TI - An evaluation of a mental health program by use of selected operating statistics. PMID- 4328909 TI - Angiographic appearnace of benign and malignant hepatic tumors in infants and children. PMID- 4328910 TI - Angiography of primary liver cancer. PMID- 4328911 TI - Angiographic demonstration of hepatoma in association with Fanconi's anemia. PMID- 4328912 TI - Primary carcinoma of the liver: clinical and radiologic manifestations. PMID- 4328914 TI - Hepatoma presenting as a skin metastasis. PMID- 4328913 TI - Positive scintiphotography of cancer of the liver with Ga 67 citrate. PMID- 4328916 TI - Triple extramammary Paget's disease. PMID- 4328915 TI - Paget's disease in metastatic breast carcinoma. PMID- 4328917 TI - Phasic REM, depression, and the relationship between sleeping and waking. PMID- 4328918 TI - [Predominance of poliovirus type 3 in hospitalized children in the isolation center of the Hospital Jesus of Guanabara]. PMID- 4328919 TI - Comparison of corticotrophin and prednisolone in treatment of idiopathic facial paralysis (Bell's palsy). AB - In a controlled trial of the effects of intramuscular corticotrophin and oral prednisolone in the treatment of acute Bell's palsy 186 successive patients with idiopathic facial palsy were grouped for age and duration of palsy. They were then allocated at random to either corticotrophin or prednisolone therapy in pairs. The results were:(1) 94 received corticotrophin and 32 developed some degree of denervation and 92 received prednisolone and 13 developed some degree of denervation (P <0.005); (2) six of the corticotrophin group became severely denervated (less than 50% recovery) compared with none of the prednisolone group (P <0.02); (3) the best results were obtained in the younger patients (less than 45 years old) treated on the first or second day of palsy; and (4) side effects were minimal.It is concluded that oral prednisolone is the treatment of choice for idiopathic facial (Bell's) palsy. PMID- 4328920 TI - Aetiology of Bell's palsy. PMID- 4328921 TI - L2C guinea pig leukemia: immunoprotection and immunotherapy. PMID- 4328922 TI - Mucus-producing adenopapillary (non-epidermoid) carcinoma of the parotid gland. PMID- 4328923 TI - Minute pulmonary chemodectoma. PMID- 4328924 TI - Histologic appearance of gastric carcinoma in high and low mortality countries: comparison between Kyushu, Japan and Minnesota, USA. PMID- 4328925 TI - Ultrastructure of a benign liver cell adenoma. PMID- 4328927 TI - Transformation of human cells by virus and chemical carcinogen in vitro. PMID- 4328926 TI - Pulmonary metastases from ceruminous adenocarcinoma (cylindroma) of external auditory canal. PMID- 4328928 TI - Bilateral Wilms' tumor. Seven personal cases with observations. PMID- 4328929 TI - Gas chromatography in the estimation of urinary metanephrines and VMA. PMID- 4328930 TI - Effect of aminoglutethimide on lipid fractions in rat adrenals. PMID- 4328931 TI - Steroid-mediated stimulation of aerobic glycolysis by intact mouse adrenal glands in vitro. PMID- 4328932 TI - Loss of adenyl cyclase hormone receptors during purification of fat cell plasma membranes. PMID- 4328933 TI - Triiodothyronine stimulation of cyclic adenosine 3',5'-monophosphate accumulation in fat cells. PMID- 4328934 TI - Calorigenic action of triiodothyronine on white fat cells: effects of ouabain, oligomycin and catecholamines. PMID- 4328935 TI - A specific, reversible, macromolecular inhibitor of hepatic glucagon responsive adenyl cyclase. PMID- 4328937 TI - [Correlations between peptic acid activity of the gastric juice and metabolico enzymatic activity of the gastric mucosa under the influence of mineral water of an alkaline type]. PMID- 4328936 TI - Studies on growth hormone secretion. I. Effects of dibutyryl cyclic AMP, theophylline, epinephrine, ammonium ion, and hypothalamic extracts on the release of growth hormone from rat anterior pituitaries in vitro. PMID- 4328938 TI - [Effect of perchlorate and stabile iodide on the elimination of radioactive iodine (I 131 ) from the body]. PMID- 4328939 TI - Studies on viability of Variola virus. I. Viability of Variola virus in smallpox material on glass slides, in capillary tubes on filter paper and cotton threads. PMID- 4328940 TI - Some aspects of the measurement of 32 P Cerenkov radiation in water by a liquid scintillation spectrometer. PMID- 4328941 TI - Pulmonary adenocarcinoma--metastasis to a lesser toe. PMID- 4328942 TI - Selective blocking of somatic neuromuscular transmission in the larval wax moth, Galleria mellonella, by bromolysergic acid diethylamide. PMID- 4328943 TI - Longevity of strains from individual foci of human amnion cells transformed by simian virus 40. PMID- 4328944 TI - Glucose-6-phosphate phosphohydrolase activity in erythrocytes of cancer patients and blood, liver, and brain of tumor-bearing rats. PMID- 4328945 TI - Antibodies to various herpesviruses in sera from patients with sarcoidosis. PMID- 4328946 TI - Potentiation of human interferon production by superinduction. PMID- 4328947 TI - Heterotransplantation of two human lymphoid cell lines transformed in vitro by Epstein-Barr virus. PMID- 4328948 TI - Correlation between presence of leukemia virus in cultured cells and their immunogenicity in a leukemia isotransplant system. PMID- 4328949 TI - Comparative study of metabolic profiles of primary hepatoma, regenerating liver, and liver in newborn Swiss mice. PMID- 4328950 TI - Spontaneous occurrence of precipitating antibodies to the mammary tumor virus in mice. PMID- 4328951 TI - Malignant and transforming activity of Rous sarcoma virus (RSV). 3. Detection of tumor-specific transplantation and membrane antigens in mouse cell lines transformed in vitro by RSV. PMID- 4328952 TI - Malignant lymphoma with lymphocytic leukemia induced in owl monkeys by Herpesvirus saimiri. PMID- 4328953 TI - C-type virus in tumor tissue of a woolly monkey (Lagothrix spp.) with fibrosarcoma. PMID- 4328954 TI - Subcutaneous papillomatous cysts produced by bovine papilloma virus. PMID- 4328955 TI - Liver carcinomas induced in rats by single administration of dimethylnitrosamine after partial hepatectomy. PMID- 4328956 TI - Interactions of cortical and retinal projections on single neurons of the cat's superior colliculus. PMID- 4328957 TI - Rates of transmitter turnover in the cat superior cervical ganglion estimated by electrophysiological techniques. PMID- 4328959 TI - Synaptic processing of taste-quality information in thalamus of the rat. PMID- 4328958 TI - Rates of transmitter turnover at the frog neuromuscular junction estimated by electrophysiological techniques. PMID- 4328960 TI - Electrophysiological evidence for an input to lateral reticular nucleus from collaterals of dorsal spinocerebellar and cuneocerebellar fibers. PMID- 4328961 TI - Influence of superior colliculus on cat neck motoneurons. PMID- 4328962 TI - Precocious puberty with masculinization due to terato-chorio-gonadoblastoma. PMID- 4328963 TI - [Influence of lactate and pyruvate on glucose absorption in vitro by the everted rat intestine]. PMID- 4328964 TI - Comparative ultrastructure of chick fibroblasts in vitro at early and late stages during their growth span. PMID- 4328966 TI - An atypical bat thyroid extrafollicular cell. PMID- 4328965 TI - Stabilization of neurofilaments by vincristine sulfate in low ionic strength media. PMID- 4328967 TI - Fibrillar bundles in canine lymphomas: an ultrastructural study. PMID- 4328968 TI - The ultrastructure of testicular spermatozoa in two species of Rana. PMID- 4328970 TI - [Primary gallbladder carcinoma in the light of our own surgical observations]. PMID- 4328969 TI - Effects of vasoactive drugs on renal vascular resistance in obstructive disease. PMID- 4328971 TI - [Cancer of the small intestine as a cause of psychotic disturbances]. PMID- 4328972 TI - [Results of a virological survey made in an open child community during an epidemic of acute aseptic meningitis]. PMID- 4328973 TI - The radiology of tumors of the heart. PMID- 4328974 TI - [Study on the viral etiology of acute diarrhea in infants and influence of Sabin vaccination on the enterovirus flora]. PMID- 4328975 TI - [Experience in the study of arterial hypertension, with special reference to the study of renovascular origin]. PMID- 4328977 TI - Insulin secretion in Bantu with siderosis or hepatoma. PMID- 4328976 TI - Oestrogens and osteoporosis. PMID- 4328978 TI - The children's tumour clinic in Port Elizabeth. PMID- 4328979 TI - Inhibitors of viral nucleic acid transcriptases. PMID- 4328980 TI - [Removal of juvenile fibroma of the nasopharynx under endotracheal anesthesia with arterial hypotension]. PMID- 4328982 TI - [Therapeutic effects of customary condiments]. PMID- 4328981 TI - [Clinoco-roentgenological observations at immediate and remote periods after surgical and combined therapy of patients with juvenile angiofibroma of the cranial base]. PMID- 4328983 TI - Nephroblastoma in Ibadan. A review of thirty-five cases. PMID- 4328984 TI - Cytochemical (icroscopic and quantitative) studies on cultured cells and biopsies of Burkitt's lymphoma. (Including a study of the effect of endoxanon lysosomal enzymes). PMID- 4328985 TI - [Free nucleotide content in muscles following administration of ACTH and hydrocortisone]. PMID- 4328986 TI - [Cytogenetic study of Rous sarcoma induced by Carr-Zilber strain virus in adult macaca-rhesus]. PMID- 4328987 TI - Isoenzymes of lactic dehydrogenase in bone and bone marrow plasma. PMID- 4328988 TI - Plasma renin in idiopathic orthostatic hypotension: differential response in subjects with probable afferent and efferent autonomic failure. PMID- 4328989 TI - Comparison of charcoal and attapulgite as gastrointestinal sequestrants in acute drug ingestions. PMID- 4328990 TI - Relevance of programs for emotionally disturbed youth in other lands. PMID- 4328992 TI - Recurrent viral infection: an annotation. PMID- 4328991 TI - Characteristics of clients and continuity of care into the community. PMID- 4328993 TI - Long-term cultivation of mammalian cell strains in protein- and lipid-free chemically defined synthetic media. PMID- 4328994 TI - Specialization of cell surfaces in contact-inhibited human glia-like cells in vitro. PMID- 4328995 TI - Induction of homokaryocyte, heterokaryocyte and hybrid formation by lysolecithin. PMID- 4328996 TI - Cholesterol biosynthesis in WI-38 and WI-38VA13A tissue culture cells. PMID- 4328997 TI - A comparison of the susceptibility to fusion of cell monolayers of human origin by inactivated Sendai virus. PMID- 4328998 TI - Histone phosphokinase levels in synchronized mammalian cells. PMID- 4328999 TI - Paralysis of horses associated with equine herpesvirus 1 infection. PMID- 4329000 TI - Prevalence of embryonal nephroma in slaughtered swine. PMID- 4329001 TI - The regulation of aldosterone secretion in anephric man. AB - The regulation of aldosterone secretion in anephric man was investigated in studies on nephrectomized patients who were being intermittently hemodialyzed while awaiting renal transplantation. The effects of supine and upright posture on the concentration of plasma aldosterone on the 1st day postdialysis and on a 3rd or 4th day postdialysis were compared to the effects of postural variation in normal subjects who were on a low sodium intake and on a high sodium intake. In contrast with the normal subjects who exhibited higher concentrations of plasma aldosterone after 2 hr of upright posture than in the supine position and low concentrations of plasma aldosterone on a high sodium intake, the anephric patients showed less consistent variations in plasma aldosterone due to changes in posture and exhibited higher concentrations of plasma aldosterone on the 3rd or 4th day postdialysis, despite an increase in body weight, than on the 1st day postdialysis. The increase in the concentration of plasma aldosterone in the anephric patients between the 1st day postdialysis and the 3rd or 4th day postdialysis indicates that aldosterone secretion is not responding primarily, in this situation, to volume-related stimuli. There was a high degree of correlation between the concentration of plasma aldosterone and the corresponding levels of serum potassium concentration, which also rose significantly between the 1st day postdialysis and the 3rd or 4th day postdialysis. Furthermore, when potassium accumulation between dialyses was prevented in three of these patients, the concentration of plasma aldosterone fell to minimally detectable levels. The results of these studies suggest that the primary regulator of aldosterone secretion in the absence of the kidneys is potassium. PMID- 4329002 TI - Effects of Ca++ and prostaglandin E1 on vasopressin activation of renal adenyl cyclase. AB - Adenyl cyclase activity was assayed in crude homogenates of the renal cortex, medulla, and papilla of the golden hamster. The specific activity (moles C AMP/unit of time per mg protein of tissue) of the enzyme under basal conditions, was greatest in papilla, somewhat lower in medulla, and least in cortex. On an absolute scale, the sensitivity to vasopressin was greater in the medullary and papillary than in the cortical homogenates. In addition, at concentrations of 0.1 1.0 mm, CaCl(2) inhibited the enzyme in the order papilla > medulla > cortex. These results imply the existence of distinct differences in the composition of the adenyl cyclase-receptor complex in various parts of the kidney. We proposed that Ca(++) inhibits the core enzyme directly since at the minimally inhibitory concentration (0.1 mm), CaCl(2) reduced to an equivalent extent (a) basal activity, (b) the response to graded doses of vasopressin (0.5 to 50.0 mU/ml) and (c) the response to maximal stimulatory concentrations of NaF (10 mm). Prostaglandin E(1) (PGE(1) = 10(-7)m) had no effect on either basal adenyl cyclase activity or the response to 10 mm NaF in medullary and papillary homogenates. 7-Oxa-13-prostynoic acid (10(-4)m) similarly had no effect under basal conditions or on stimulation with NaF in medullary homogenates. Both fatty acids, however, inhibited the enzymic response to vasopressin, particularly at low concentrations of the peptide. The straight-chain fatty acid, 11-eicosanoic acid (10(-7)m), was inactive on basal activity or on the response to vasopressin. The possibility that PGE(1) modifies the coupling mechanism between the core enzyme and the hormone-specific receptor is discussed. PMID- 4329004 TI - An electron microscopic study of synaptic morphology in the oculomotor nuclei of three inframammalian species. PMID- 4329003 TI - Energy metabolism in human erythrocytes. I. Effects of sodium fluoride. AB - Exposure of red cells to fluoride produces a variety of metabolic alterations, most of which are based upon the secondary effects of enolase inhibition, which reduces pyruvate synthesis and interferes with the regeneration of diphosphopyridine nucleotide (NAD). Adenosine triphosphate (ATP) is consumed in the hexokinase and phosphofructokinase reactions but is not regenerated since the deficiency of NAD limits glyceraldehyde phosphate dehydrogenase. ATP depletion in the presence of fluoride and calcium induces a massive loss of cations and water. Of the other known sites of ATP utilization, membrane-bound ATPase is inhibited by fluoride, but the incorporation of fatty acids into membrane phospholipids is unaffected until ATP is depleted. The addition of methylene blue to fluoride treated red cells regenerates NAD, permitting triose oxidation and the generation of 3-phosphoglycerate and 2,3-diphosphoglycerate. Enolase inhibition is then partially overcome by mass action, and sufficient glycolysis proceeds to maintain the concentration of ATP. This in turn prevents the massive cation and water loss, and permits membrane phospholipid renewal to proceed. Membrane ATPase activity is not restored by the oxidant so that normal cation leakage remains unopposed by cation pumping in red cells exposed to the combination of fluoride and methylene blue. PMID- 4329005 TI - Positive chronotropic response of cultured isolated rat heart cells to N6,2'-O dibutryl-3',5'-adenosine monophosphate. PMID- 4329006 TI - Prevention of various forms of metabolic myocardial necrosis by catatoxic steroids. PMID- 4329008 TI - The effect of type D botulinum toxin on frog neuromuscular junctions. AB - 1. Botulinum toxin type D blocks neuromuscular transmission in frogs. Motor nerve impulses continue to invade the nerve terminals but cease to evoke the phasic release of transmitter normally associated with them.2. Sensory receptors in the muscle continue to generate impulses even after 4 days of continuous exposure to botulinum toxin.3. Contrary to expectations, spontaneous miniature end-plate potentials did not disappear completely after botulinum intoxication; they still occurred, although with reduced frequency, in most end-plates. These miniature potentials had a skew amplitude distribution instead of the bell-shaped distribution of normal end-plates.4. The electron-microscopic appearance of botulinum-poisoned end-plates was not obviously altered.5. Even though after botulinum nerve impulses fail to release transmitter, tetanic nerve stimulation causes an increase in the frequency of miniature end-plate potentials. Many of the unit potentials which appear during the tetanic period are of an amplitude which is larger than that of spontaneous potentials, indicating that a different class of unit is being released preferentially. Some implications of this finding are briefly discussed. PMID- 4329009 TI - Synovial sarcoma: an analysis of its response to radiation. PMID- 4329007 TI - [Cytophysiological study of the parapineal organ of Lamperta laneri]. PMID- 4329011 TI - Vitamin C and the common cold. PMID- 4329010 TI - The occurrence of SV40-Neutralizing antibodies in sera of patients with genitourinary carcinoma. PMID- 4329012 TI - [Clinical and in vitro demonstration of the synergistic effects of oxytetracycline and polymyxin B on Pseudomonas growth]. PMID- 4329013 TI - Hypoglycemia during pregnancy following pancreatoduodenectomy. PMID- 4329015 TI - [So-called carcinomatous neuropathy]. PMID- 4329014 TI - Effects of ions on thyrotrophin and prostaglandin E stimulation of glucose oxidation and adenyl cyclase-cyclic AMP system in dog thyroid slices. PMID- 4329016 TI - [Neuropathy caused by organic phosphate and organic chlorine poisoning]. PMID- 4329017 TI - The ultrastructural changes produced by infectious laryngotracheitis virus in tracheal epithelium of the fowl. PMID- 4329018 TI - Sequential brain imaging as an aid in understanding disease etiology. PMID- 4329019 TI - Monoplegia and false aneurysm. PMID- 4329020 TI - Ultrastructural differentiation and progesterone- 14 C metabolism in cultured cells of fetal rat adrenals under influence of ACTH. PMID- 4329021 TI - Anterolateral approach to the orbit. PMID- 4329022 TI - A comparison of the outer layers of Blastocystis hominis with the cyst walls of certain common intestinal protozoa. PMID- 4329023 TI - Supernumerary kidney with Wilms' tumor. PMID- 4329024 TI - [Experimental studies of ACTH effect on tonsils]. PMID- 4329026 TI - Scientific autographs. IV. Peyton Rous (1879-1970) and his Nobel Prize. PMID- 4329027 TI - The biological significance of the prostaglandins. PMID- 4329025 TI - Chemical transfer of learned behavior. PMID- 4329028 TI - The effect of PGE-1 on cyclic AMP and ion movements in turkey erythrocytes. PMID- 4329029 TI - Effect of prostaglandin E-1 on osmotic water flow and sodium transport in the toad bladder. PMID- 4329030 TI - In vitro effects of prostaglandins on thyroid gland metabolism. PMID- 4329031 TI - Effects of prostaglandins on function and cyclic AMP levels of human blood platelets. PMID- 4329032 TI - Effect of prostaglandins and cyclic AMP on gastric secretion. PMID- 4329034 TI - The effect of prostaglandins on the adenyl cyclase of the bovine corpus luteum. PMID- 4329033 TI - Prostaglandin E compounds and sympathetic neuromuscular transmission. PMID- 4329035 TI - [Pathology of so-called "myoid tumors" of the gastrointestinal system. Study based on 3 unusual cases]. PMID- 4329036 TI - Rupture of the tibialis anterior tendon simulating peroneal nerve palsy. PMID- 4329037 TI - Inhibitory action of rhein on the reduced nicotinamide adenine dinucleotidedehydrogenase complex of mitochondrial particles and on other dehydrogenases. PMID- 4329038 TI - Drug effects on catalase activity in the mammalian cell. The role of the cell in drug action. PMID- 4329039 TI - [Enzymatic activities of retina and anthocyanoside extracts of Vaccinium myrtillus (lactate dehydrogenase, alpha-hydroxybutyrate dehydrogenase, 6 phosphogluconate dehydrogenase, glucose-6-phosphate dehydrogenase, alpha glycerophosphate dehydrogenase, 5-nucleotidase, phosphoglucose isomerase)]. PMID- 4329040 TI - Effect of chlorpromazine on permeability of the toad bladder. PMID- 4329041 TI - Infective complications of choledochotomy with T-tube drainage. PMID- 4329042 TI - Prolonged corticotrophic action of a synthetic substituted 1-18 ACTH. AB - The adrenocorticotrophic effects of a synthetic corticotrophin analogue, alpha(1 18) ACTH with D-serine(1), lysine(17), and lysine amide(18) substitutions has been studied. It is effective after both intramuscular and subcutaneous administration and compared with tetracosactrin depot (Synacthen depot, Cortrosyn depot) it has a similarly prolonged time course of action-about 24 hours after 0.5 mg and 30 hours after 1 mg. Unlike tetracosactrin depot, however, it is well absorbed when given intranasally and does not produce painful reactions at the site of injection. Its prolonged time course of action does not depend on a formulation designed to delay its release from the injection site but most probably on a decreased rate of degradation in the circulation. PMID- 4329043 TI - Transient dysaesthesiae and persistent leucocytosis after clioquinol therapy. PMID- 4329044 TI - Assay of S-adenosylmethionine in human blood. PMID- 4329045 TI - A rapid competitive protein-binding assay for plasma progesterone. PMID- 4329046 TI - Eosinophilic gastritis. A case report. PMID- 4329047 TI - Tone and reactivity of vascular smooth muscle in germfree rat mesentery. AB - Microcirculatory observations and measurements were made by in vivo microscopy in 35 germfree and 26 conventional rats. The rate of vasomotor activity, "vasomotion," of precapillary arterioles was found markedly decreased in the germfree animals. All precapillary vessels in the germfree rats were markedly hyporeactive to the catecholamines, epinephrine and norepinephrine, as compared to similar vessels of conventional rats. The vessels in the germfree animals were also less responsive to vasopressin but not angiotensin. A greater lumen:wall ratio of primary arterioles, but not of secondary arterioles and metarterioles, found in germfree animals is related to change in vessel lumen alone without concomitant change in wall thickness. The germfree rat is characterized by possessing a hypotonic, catecholamine-refractory mesoappendix microvasculature. PMID- 4329048 TI - The immune systems of mice reared in clean and in dirty conventional laboratory farms. I. Life expectancy and pathology of mice with long life-spans. PMID- 4329049 TI - Study of the effect of vaccination with live poliomyelitis vaccine on the circulation of enteroviruses in the population. PMID- 4329050 TI - Thin films of glass and their application to biomedical sensors. PMID- 4329051 TI - [Electropolygraphic study of sleep and electromyographic study of a case of vascular lesion of the brain stem with unusual decerebration-hypertension seizures]. PMID- 4329052 TI - Binucleate DNA-synthesizing cells in cytomegalovirus infection after extracorporeal circulation. PMID- 4329053 TI - [Principle and certain problems in radioimmunoassay]. PMID- 4329054 TI - [Radioimmunoassay of ACTH]. PMID- 4329055 TI - [Radioimmunoassay of angiotensin]. PMID- 4329056 TI - Infections with viruses, Mycoplasma pneumoniae and bacteria in acute respiratory illness. A study of hospitalized patients, patients treated at home, and healthy subjects. PMID- 4329057 TI - Herpes simplex virus as a cause of allergic mucocutaneous reactions (ectodermosis erosiva pluriorificialis, Stevens-Johnson's syndrome, etc.) and generalized infection. PMID- 4329058 TI - Varicelliform eruptions in herpes zoster--some clinical and serological observations. PMID- 4329059 TI - Adrenocortical function in fever. PMID- 4329060 TI - Infections with viruses in patients hospitalized with acute respiratory illness, Stockholm 1963-1967. PMID- 4329062 TI - Complement-fixing and neutralizing antibodies against cytomegalovirus strain AD 169 in sera from infants with cytomegalovirus infection. PMID- 4329061 TI - Cytomegalovirus antibodies in donors of fresh blood to patients submitted to open heart surgery. PMID- 4329063 TI - Serological studies on cytomegalovirus infection in relation to infectious mononucleosis and similar conditions. PMID- 4329064 TI - Adenovirus type 8-associated follicular conjunctivitis and keratoconjunctivitis in patients subjected to tonometry. I. Virological findings. PMID- 4329065 TI - Adenovirus type 8-associated keratoconjunctivitis: hospital infections and secondary spread in Stockholm, 1967. PMID- 4329066 TI - Cholangiocarcinoma in a cat (a case report). PMID- 4329067 TI - An outbreak of the conjunctival form of infectious bovine rhinotracheitis virus infection. PMID- 4329068 TI - Enzyme cytochemistry of the abraded gastric surface epithelium. An aid in the diagnosis of early atrophic gastritis and focal intestinal metaplasia. PMID- 4329069 TI - Neoplasms of the small intestine. PMID- 4329070 TI - Hepatocellular carcinoma, positive Australia (hepatitis-associated) antigen and sarcoidosis. PMID- 4329072 TI - [Explanation of a method for the assay on Drosophila of vesicular stomatitis virus adapted to that insect]. PMID- 4329071 TI - Serum mucoprotein and guanase levels in the differential diagnosis of jaundice. PMID- 4329073 TI - [On virus-chromosome relationship. VII. Further karyological studies on cell cultures derived from Shope's papillomas]. PMID- 4329075 TI - [Significance and limits on the term "functioning ovarian tumor". Case review]. PMID- 4329074 TI - Renal transplantation in infants and children. PMID- 4329076 TI - [Pharmacology of 3,7-dimethyl-1-(5-oxo-hexyl)-xanthine, a new peripheral vasodilator agent]. PMID- 4329077 TI - The chemical diagnosis of ganglioneuroma and neuroblastoma using random specimens of urine. PMID- 4329079 TI - [Glucagon]. PMID- 4329078 TI - [Insulin and carbohydrate metabolism]. PMID- 4329080 TI - [Regulation of blood sugar and hormones]. PMID- 4329081 TI - Reaching families of hospitalized mental patients: a group approach. PMID- 4329082 TI - Community placement in comprehensive mental health planning: issues and obstacles. PMID- 4329083 TI - [Effect of a-substituted glycerin ether on the central nervous system]. PMID- 4329084 TI - The toxicological analysis of the tetraethylpyrophosphate (T.E.P.P.) intoxication in man. PMID- 4329085 TI - Toxicopathologic studies of a piperidino thenyl ethylamine. (CIBA go. 2825). PMID- 4329086 TI - [Experimental manganese poisoning with a view to biologic prevention]. PMID- 4329087 TI - [Risks of secondary circulatory failure at the time of excessive perfusion with vasoconstrictor agents]. PMID- 4329088 TI - [Microdetermination of lead in biologic media]. PMID- 4329089 TI - [Determination of cyanide ion in the atmosphere, drinking water, industrial effluents and biologic media by means of a specific electrode]. PMID- 4329091 TI - Synaptic linkage in the vestibulo-ocular reflex pathway of rabbit. PMID- 4329090 TI - Blood alcohol in poisoned patients. PMID- 4329092 TI - Evidence for a rapid transmission in the cat vestibulo-ocular pathway. PMID- 4329093 TI - [The salidiuretic interaction of angiotensin II and furosemide in ascitogenic hepatic cirrhosis]. PMID- 4329094 TI - [A new combined test of ovarian inhibition and adrenal stimulation: behavior of urinary total and fractionated 17-KS, of 17-hydroxycorticoids, pregnanediol and pregnanetriol]. PMID- 4329095 TI - [On the pituitary-inhibiting action and pharmacokinetics of some synthetic corticosteroids]. PMID- 4329096 TI - Bacteria, bile salts, and intestinal monosaccharide malabsorption. AB - Intestinal monosaccharide transport was studied in a series of rats with a self filling jejunal blind loop using 3mM arbutin (p-hydroxyphenyl-B-glucoside) or 1mM D-fructose as substrate in vitro and 10 mM arbutin or 5mM D-fructose in vivo. These results were compared with changes in the bacterial flora and state of conjugation of intraluminal bile salts in those animals. Observations were also made of the microscopic and ultrastructural appearances of the small-intestinal epithelium. In the small intestine of blind-loop rats intestinal monosaccharide transport is impaired, and in vitro is most marked in the blind loop, less so in the efferent jejunum, and not significantly altered in the afferent jejunum. A similar pattern of disturbed monosaccharide absorption was demonstrated by perfusions in vivo. The degree of the transport defect correlates closely with the luxuriance of the anaerobic flora, which averaged 10(8) per millilitre in the blind loop, 10(7) in the efferent jejunum, and 10(6) in the afferent jejunum. A similar pattern of abnormality of bile salt conjugation occurred. In the blind loop the ratio of free to conjugated bile salts was grossly abnormal; this disturbance was somewhat less marked in the efferent jejunum and considerably less in the intraluminal contents of the afferent jejunum. An irregularly distributed lesion, consisting of swelling and vacuolation of microvilli and intracellular organelles, was demonstrated in the small-intestinal epithelium of blind-loop animals. Impaired absorption of monosaccharides is a further consequence of bacterial contamination of the upper gut. It is suggested that this defect is caused by the presence of high levels of deconjugated bile salts produced by an abnormal anaerobic bacterial flora in the small intestine. PMID- 4329098 TI - Functional stimulation of disabled limbs. PMID- 4329099 TI - Immobilization of tiny hands. PMID- 4329100 TI - Studies on the substrate specificity of acylneuraminate pyruvate-lyase. PMID- 4329097 TI - Further studies on streptozotocin therapy for a multiple-hormone-producing islet cell carcinoma. AB - A patient with a multiple-hormone-producing islet cell carcinoma, who had previously been successfully treated with streptozotocin, was given three further infusions of this drug because of the redevelopment of gastric hypersecretion. Although some evidence of damage to the gastrinsecreting cells was obtained, the fasting plasma gastrin was not significantly altered and the patient died from a perforated duodenal ulcer. Serum insulin levels were considerably reduced and the patient became mildly diabetic but the main complication of treatment was a severe though reversible renal tubular defect. At necropsy considerable quantities of gastrin, but low levels of insulin and glucagon were extracted from a tumour metastasis. PMID- 4329101 TI - Pufification of a 4-methoxybenzoate O-demethylase from Pseudomonas putida. PMID- 4329102 TI - The vitamin activity of coenzyme Q 7 in reproduction in the rat. PMID- 4329103 TI - [Xanthine-oxidoreductase (E.C.1.2.3.2.) activity in riboflavin or thiamine deficient rat liver]. PMID- 4329104 TI - The effect of electrical stimulation of the hypothalamus on red cell production and destruction in the rat. PMID- 4329105 TI - Androgens and erythropoiesis. PMID- 4329106 TI - Effects of vasoactive agents on erythropoietin production. PMID- 4329107 TI - Lipid patterns in human leukocytes maintained in long-term culture. AB - The lipid composition of leukocytes maintained in long-term culture was examined in order to clarify the role of immaturity in previously observed differences between normal mature leukocytes and leukemic cells. Cell cultures derived from three types of leukocytes were examined: normal lymphocytes, Burkitt lymphoma, and chronic myelocytic leukemia. Lipid extracts were analyzed for total lipid weight, phospholipids, neutral lipids, and glycolipids. Distribution of individual phospholipids was determined by quantitative two-dimensional thin layer chromatography. The main phospholipids were phosphatidylcholine (51-54%) and phosphatidylethanolamine (24-25%), with smaller amounts of phosphatidylinositol, phosphatidylserine, sphingomyelin, and cardiolipin. All three types of cultured cells showed a remarkable similarity in total phospholipid content (17-18 x 10(-15) moles/cell) as well as in phospholipid distribution. More variation was seen in neutral lipid content. Glycolipid was abundant (17-23% of total lipid weight) and was present mostly as ceramide dihexoside. Compared with normal lymphocytes or polymorphonuclear leukocytes, the cultured cells showed increased phosphatidylcholine, decreased sphingomyelin, and decreased cholesterol content, similar to the changes found in leukemic leukocytes. These findings suggest that the altered lipid patterns found in leukemic leukocytes are a reflection of cell immaturity rather than a characteristic peculiar to the leukemic state. PMID- 4329108 TI - Studies on the hormone-sensitive lipase of adipose tissue. AB - Sucrose gradient centrifugation has been used to examine the triglyceride lipases present in extracts of rat epididymal adipose tissue. The aqueous infranatant recovered between the pellet and fat cake of tissue homogenates which had been centrifuged at 40,000 g was shown to contain two types of triglyceride lipase activity. One of these appears in the 15s region and has been identified as the active form of the "hormone-sensitive lipase" believed to be responsible for initiating the hydrolysis of tissue triglyceride stores in response to lipolytic stimuli. The activity of this enzyme was selectively increased in extracts prepared from tissue exposed to epinephrine and decreased in extracts of insulin treated tissue. The increased lipolytic activity of extracts of tissue from fasted or fasted-refed rats was also found largely in this region. When the tissue was incubated with orthophosphate-(32)P, radioactivity was incorporated into a protein migrating at 15s. A second peak of triglyceride lipase activity appeared in the 6s region coincident with the location of the monoglyceride and diglyceride lipase activities. The amount of 6s triglyceride lipase activity did not correlate with changes in the lipolytic activity of the tissue from which the extracts were prepared, and its physiological function remains to be elucidated. The lipoprotein lipase and the short-chain triglyceride lipase ("tributyrinase") each moved more slowly in the gradient than the 6s triglyceride lipase. Both the 6s and 15s enzymes were shown to be present in washed adipocytes isolated from the tissue by collagenase digestion. PMID- 4329111 TI - Electron microscope study of the denaturation of Polyoma virus DNA. PMID- 4329109 TI - Four-directional-development thin-layer chromatography of lipids using trimethyl borate. AB - Solvent mixtures containing trimethyl borate virtually eliminated the pronounced interconversion of 1,2- and 1,3-dipalmitins during their resolution by thin-layer chromatography on Silica Gel G. With trimethyl borate, an average of 1-2% of 1,2 dipalmitin was converted to 1,3-dipalmitin. A four-directional-development TLC procedure incorporating trimethyl borate resolves cholesteryl glucoside, ceramides, monogalactosyl diglyceride, 1- and 2-monopalmitin, palmitic acid, cholesterol, 1,2- and 1,3-dipalmitin, tripalmitin, methyl palmitate, cholesteryl palmitate, beta-carotene and some of its degradation products, squalene, and tetracosane. Digalactosyl diglyceride, phosphatidic acid, phosphatidylglucose, cerebrosides, and other phospholipids remain near the origin. A mixture containing triolein, 1,2- and 1,3-diolein, 1- and 2- monoolein, oleic acid, and cholesterol was resolved in one dimension. A similar series of palmitic containing neutral lipids was also resolvable in one dimension. These procedures were applied to the TLC of human sera lipids. PMID- 4329110 TI - On the analysis of long-chain alkane diols and glycerol ehters in biochemical studies. AB - The chromatographic behavior of 1,2-, 1,3-, 1,4-, and 1,12-long-chain alkane diols and 1-O-alkylglycerols and their derivatives has been compared. Thin-layer chromatography on Silica Gel G gives poor separations of the 1,2-, 1,3-, and 1,4 alkane diols, O-alkylglycerols, and some of their isopropylidene derivatives. However, gas-liquid chromatography on 10% EGSS-X (coated on 100-120 mesh Gas Chrom P) resolves the isopropylidenes of the alkane diols and O-alkylglycerols. We also document the formation of 1,3-alkane diols (after LiAlH(4) reduction) from 1-(14)C-labeled fatty acids incubated with mitochondrial fractions from heart and liver of rats. The labeled 1,3-alkane diol was identified by gas-liquid chromatography of its isopropylidene derivative and by its behavior after periodate oxidation. These results serve to caution investigators in the glycerol ether field against incorrect interpretation of data obtained on the incorporation of labeled fatty acids into alkyl ether bonds of glycerolipids. The methodology described points out a technique for distinguishing several types of alkane diols from O-alkylglycerols. PMID- 4329113 TI - Histo-enzymological observations on spermatozoa of inbred strains of mice. PMID- 4329112 TI - The maintenance of gestation and the initiation of lactation in the mouse in the absence of pituitary prolactin. PMID- 4329114 TI - [Epidemiologic evaluation of natural populations of Aedes togoi Theobald in Soviet Primor'e]. PMID- 4329116 TI - Synergism of cobalt and thanol. PMID- 4329115 TI - Cholangiocarcinoma associated with thorium dioxide (thorotrast): report of a case. PMID- 4329117 TI - Cytomegalovirus antibody in patients with carcinoma of the uterine cervix. PMID- 4329118 TI - A case of vagal body tumour: chemodectoma of the ganglion nodosum. PMID- 4329119 TI - Characteristics of Staphylococcus pyogenes phage type 84-85. PMID- 4329120 TI - [Nuclear envelope]. PMID- 4329121 TI - [Enzymatic organization of mitochondrial membranes]. PMID- 4329122 TI - Hypersensitivity reactions to ampicillin in cytomegalovirus mononucleosis. PMID- 4329124 TI - Endocrine regulation of human gestation. Report of a WHO Scientific Group. PMID- 4329123 TI - Clinical course and prognosis of whooping-cough in Swedish children during the first six months of life. A study of hospitalized patients 1958-67. PMID- 4329125 TI - [New concepts concerning the morphology and function of synapses in the central nervous system]. PMID- 4329126 TI - The uptake of radio-active glucose in vivo and in vitro by the metacercaria of Diplostomum phoxini (Faust) and its conversion to glycogen. PMID- 4329127 TI - [Trematodes collected from rodents from the Ivory Coast]. PMID- 4329128 TI - Cell junctions and their role in transmural diffusion in the embryonic chick heart. PMID- 4329129 TI - [Origin and differentiation of the tegument of digenetic trematodes: ultrastructural study of Cercaria pectinata (larva of Bacciger bacciger, Fellodis tomatidae)]. PMID- 4329130 TI - [Cellular types and differentiation of Scyllium canicula embryo adenohypophysis (Chondrichthyes). Electron microscopic study]. PMID- 4329131 TI - Postnatal excitability changes of the ankle monosynaptic reflexes in the cat. PMID- 4329132 TI - Recurrent and antidromic effects on the monosynaptic reflex during postnatal development in the cat. PMID- 4329134 TI - [Enzymatic histochemical studies of the angle of the anterior chamber. 2. Some enzymes relating to carbohydrate metabolism]. PMID- 4329133 TI - The effect of protriptyline on the disappearance and nerve impulse induced release of labelled metaraminol in the rat. PMID- 4329135 TI - Variables associated with split-period sleep regimes. PMID- 4329136 TI - Epilepsy and medical examinations of flight personnel, importance and difficulty of diagnosis. PMID- 4329138 TI - Cytomegalic inclusion disease of a nineteen-week fetus. Case report including a study of the placenta. PMID- 4329139 TI - Angiographic demonstration of persistent trophoblastic disease. PMID- 4329137 TI - Observations on the capillary vascular pattern in ovarian tumors. PMID- 4329141 TI - Granular cell tumor (myoblastoma) of the stomach. PMID- 4329142 TI - Carcinoma of the posterior pharyngeal wall. PMID- 4329140 TI - The psychiatric day center in the treatment of the chronic schizophrenic. PMID- 4329143 TI - Effect of experimental saline lavage on pulmonary mechanics and morphology. PMID- 4329144 TI - The relation between tetanic fade and receptor occlusion in the presence of competitive neuromuscular block. PMID- 4329145 TI - The immunologic and adrenergic aspects of asthma. PMID- 4329146 TI - Structure of Micrococcus cryophilus after freeze-etching. PMID- 4329147 TI - Bacteremia and local infections with nasal packing. PMID- 4329149 TI - [Shunt volume determination using radioisotope labelled albumin particles for the differential diagnosis of brain tumors]. PMID- 4329150 TI - [Amebae in the human biliary tract]. PMID- 4329148 TI - Granular cell myoblastoma and carcinoma of the larynx. PMID- 4329151 TI - Interaction of estrogen and progesterone in chick oviduct development. 3. Tubular gland cell cytodifferentiation. AB - Administration of estrogen (E) to immature chicks triggers the cytodifferentiation of tubular gland cells in the magnum portion of the oviduct epithelium; these cells synthesize the major egg-white protein, ovalbumin. Electron microscopy and immunoprecipitation of ovalbumin from oviduct explants labeled with radioactive amino acids in tissue culture were used to follow and measure the degree of tubular gland cell cytodifferentiation. Ovalbumin is undetectable in the unstimulated chick oviduct and in oviducts of chicks treated with progesterone (P) for up to 5 days. Ovalbumin synthesis is first detected 24 hr after E administration, and by 5 days it accounts for 35% of the soluble protein being synthesized. Tubular gland cells begin to synthesize ovalbumin before gland formation which commences after 36 hr of E treatment. When E + P are administered together there is initially a synergistic effect on ovalbumin synthesis, however, after 2 days ovalbumin synthesis slows and by 5 days there is only 1/20th as much ovalbumin per magnum as in the E-treated controls. Whereas the magnum wet weight doubles about every 21 hr with E alone, growth stops after 3 days of E + P treatment. Histological and ultrastructural observations show that the partially differentiated tubular gland cells resulting from E + P treatment never invade the stroma and form definitive glands, as they would with E alone. Instead, these cells appear to transform into other cell types-some with cilia and some with unusual flocculent granules. We present a model of tubular gland cell cytodifferentiation and suggest that a distinct protodifferentiated stage exists. P appears to interfere with the normal transition from the protodifferentiated state to the mature tubular gland cell. PMID- 4329153 TI - Contact-inhibited revertant cell lines isolated from SV40-transformed cells. I. Biologic, virologic, and chemical properties. AB - Two contact-inhibited "revertant" cell lines were isolated from an SV40 transformed mouse 3T3 cell line (SV-3T3) after exposure to 5-fluoro-2' deoxyuridine. Revertant cells resembled 3T3 cells morphologically and grew to saturation densities which were similar to those of 3T3 cells; however, revertant cells readily formed both single and multinucleated giant cells in confluent cultures. SV40 virus was rescued from revertant cells by fusion with permissive monkey cells. The rescued virus transformed 3T3 cells with the same efficiency as wild type virus, and produced transformed colonies which were phenotypically similar to those produced by wild type virus. The revertant cells also resembled normal 3T3 cells in that they contained higher quantities of sialic acid than SV 3T3 cells. An inverse correlation was found between the saturation density of cells and their sialic acid content. Collagen content, however, of revertant cells was similar to that of SV-3T3 cells. The data presented suggest that the property of contact inhibition in revertant cells is related to the sialic acid content of the plasma membrane and that changes in sialic acid content of transformed cells are not directly specified by the viral genome. PMID- 4329152 TI - Assembly of lipids into membranes in Acanthamoeba palestinensis. II. The origin and fate of glycerol- 3 H--labeled phospholipids of cellular membranes. AB - The membranes of Acanthamoeba palestinensis were studied by examination in fixed cells, and then by following the movements of glycerol-(3)H-labeled phospholipids by cell fractionation. Two previously undescribed structures were observed: collapsed cytoplasmic vesicles of cup shape, and plaques in food vacuole and plasma membrane similar in size to the collapsed vesicles. It appeared that the plaques formed by insertion of collapsed vesicles into membranes and/or that collapsed vesicles formed by pinching off of plaques. Fractions were isolated, enriched with nuclei, rough endoplasmic reticulum (RER), plasma membrane, Golgi like membranes, and collapsed vesicles. The changes in specific activity of glycerol-(3)H-labeled phospholipids in these membranes during incorporation, turnover, and after pulse-labeling indicated an ordered sequence of appearances of newly synthesized phospholipids, first in nuclei and RER, then successively in Golgi membranes, collapsed vesicles, and finally, plasma membrane. In previous work we had found no large nonmembranous phospholipid pool in A. palestinensis. These observations are consistent with the hypothesis that membrane phospholipids are synthesized, perhaps as integral parts of membranes, in RER and nuclei. Subsequently, some of the newly synthesized phospholipids are transported to the Golgi complex to become integrated into the membranes of collapsed vesicles, which are precursors of the plasma membrane. Collapsed vesicles from the plasma membrane by inserting into it as plaques. When portions of the plasmalemma from food vacuoles, collapsed vesicles pinch off from their membranes and are recycled back to the cell surface. PMID- 4329154 TI - Contact-inhibited revertant cell lines isolated from SV40-transformed cells. II. Ultrastructural study. AB - The ultrastructural appearances of normal 3T3, SV40-transformed 3T3 (SV-3T3), and F1A revertant cell lines are compared. Both confluent and subconfluent cultures are described after in situ embedding of the cells for electron microscopy. There is striking nuclear pleomorphism in F1A revertant cells, with many cells having large nuclei compared to the less variable nuclear morphology of both normal 3T3 and SV-3T3 cells. Under the culture conditions used, deep infoldings of the nuclear envelope are prominent in growing cells, e.g., subconfluent normal 3T3 and confluent SV-3T3 cells. Such infoldings are infrequently seen in cultures which display contact inhibition of growth, e.g., normal 3T3 or F1A revertant cells grown just to confluence. In confluent cultures, the cytoplasmic organelles in revertant cells closely resemble those of normal 3T3 cells. In both normal and revertant cells in confluent culture, the peripheral cytoplasm (ectoplasm) has many 70 A filaments (alpha filaments), which are frequently aggregated into bundles. Alpha filaments are also abundant in the ectoplasm near regions of cell to-cell apposition and in the motile cell processes (filopodia). The abundance and state of aggregation of alpha filaments correlates with contact inhibition of movement and growth in these cell lines since fewer bundles of alpha filaments are seen in growing cells than in contact-inhibited cells. This observation suggests that these filaments may be an important secondary component in the regulation of contact inhibition of movement and, possibly, of growth in normal and revertant cells. PMID- 4329155 TI - Mitochondrial biogenesis in Neurospora crassa. I. An ultrastructural and biochemical investigation of the effects of anaerobiosis and chloramphenicol inhibition. AB - The isolation of a new class of mutants permitting facultative anaerobiosis in Neurospora crassa is described. Backcross analyses to the obligate aerobe prototroph (An(-)) indicate single nuclear gene inheritance (An(-)/An(+)). An(+) and An(-) are indistinguishable in morphology and growth rates under aerobic conditions. Anaerobic growth requires nutritional supplements that are dispensable for aerobic growth. Conidiogenesis, conidial germination, and vegetative growth rate are suppressed by anaerobiosis. An(+) mutants produce substantial quantities of ethanol under anaerobic conditions. Anaerobiosis and chloramphenicol both affect mitochondrial enzyme activity and morphology. Chloramphenicol inhibition leads to reduction in cytochrome oxidase and swollen mitochondria with few cristae. Anaerobiosis leads to reduction in both cytochrome oxidase and malate dehydrogenase activities, enlarged mitochondria with fewer cristae, enlarged nuclei, and other alterations in cellular morphology. The fine structure of anaerobically grown cells changes with the time of anaerobic growth. We conclude that either inhibition of mitochondrial membrane synthesis or inhibition of respiration might lead to the observed alterations in mitochondria. PMID- 4329156 TI - Centrosomes and microtubules during meiosis in the mushroom Boletus rubinellus. AB - The double centrosome in the basidium of Boletus rubinellus has been observed in three planes with the electron microscope at interphase preceding nuclear fusion, at prophase I, and at interphase I. It is composed of two components connected by a band-shaped middle part. At anaphase I a single, enlarged centrosome is found at the spindle pole, which is attached to the cell membrane. Microtubules mainly oriented parallel to the longitudinal axis of the basidium are present at prefusion, prophase I and interphase I. Cytoplasmic microtubules are absent when the spindle is present. The relationship of the centrosome in B. rubinellus to that in other organisms and the role of the cytoplasmic microtubules are discussed. PMID- 4329157 TI - Endocytosis in Chang liver cells. Quantitation by sucrose- 3 H uptake and inhibition by cytochalasin B. AB - The addition of 0.08 M sucrose to a culture medium containing Chang-strain human liver cells causes intense cytoplasmic vacuolation. Electron microscopy of these cells grown inferritin, time-lapse cinematography, and radioautography reveal that the vacuoles arise by endocytosis and that the sucrose is taken into the cell and localized in the vacuoles. Tracer studies demonstrate that sucrose-(3)H provides a marker for quantitation of endocytosis and that it neither induces nor stimulates endocytosis. Electron micrographs of vacuolated liver cells show microfilaments in close proximity to the inside of the plasma membrane, in the pseudopodia, and to the cytoplasmic side of the membrane surrounding endocytosis vacuoles. Cytochalasin B (CB), a mold metabolite that inhibits various types of cell motility, has a dose-dependent inhibitory effect on the uptake of sucrose (3)H by these cells. This inhibition is accompanied by a cessation of the movement of ruffles and pseudopodia on the surface of the cells and the formation of blebs which arise from the cell's surface. These morphological changes are quickly reversible upon removal of CB. Alterations in the appearance and location of microfilaments are also observed in CB-treated cells. PMID- 4329158 TI - Morphogenesis of the collagenous stroma in the chick cornea. AB - The embryonic chick corneal epithelium produces a highly structured acellular matrix beneath its basal surface during early development. This matrix, which contains collagen, serves as a morphogenetic template for subsequent stromal development in that the three-dimensional architecture of the adult corneal stroma is initially established, in miniature, in this epithelially derived connective tissue. Examination of the early corneal epithelium and matrix in both the light and electron microscope suggests that self assembly of the matrix may be one of several important factors in the morphogenesis of this early connective tissue. PMID- 4329160 TI - Myosin-like tactoids in trypsin-treated blood platelets. PMID- 4329159 TI - Golgi apparatus, GERL, and lysosomes of neurons in rat dorsal root ganglia, studied by thick section and thin section cytochemistry. AB - New insights into the ultrastructure and phosphatase localizations of Golgi apparatus and GERL, and into the probable origin of lysosomes in the neurons of fetal dorsal root ganglia and the small neurons of adult ganglia have come from studying thick (0.5-1.0 micro) as well as thin (up to 500 A) sections by conventional electron microscopy. Tilting the thick specimens, by a goniometer stage, has helped to increase our understanding of the three-dimensional aspects of the Golgi apparatus and GERL. One Golgi element, situated at the inner aspect of the Golgi stack, displays thiamine pyrophosphatase and nucleoside diphosphatase activities. This element exhibits regular geometric arrays (hexagons) of interconnected tubules without evidence of a flattened portion (saccule or cisterna). In contrast, GERL shows acid phosphatase activity and possesses small cisternal portions and anastomosing tubules. Lysosomes appear to bud from GERL. Osmium deposits, following prolonged osmication, are found in the outer Golgi element. Serial 0.5-micro and thin sections of thiamine pyrophosphatase-incubated material demonstrate that, in the neurons studied, the Golgi apparatus is a continuous network coursing through the cytoplasm. Serial thick sections of acid phosphatase-incubated tissue suggest that GERL is also a continuous structure throughout the cytoplasm. Tubules of smooth endoplasmic reticulum, possibly part of GERL, extend into the polygonal compartments of the inner Golgi element. The possible physiological significance of a polygonal arrangement of a phosphatase-rich Golgi element in proximity to smooth ER is considered. A tentative diagram of the Golgi stack and associated endoplasmic reticulum in these neurons has been drawn. PMID- 4329161 TI - Critical study of the radioimmunological assay for the dosage of the polypeptide hormones in plasma. PMID- 4329162 TI - Effect of supplemental phytase on the utilization of phytate phosphorus by chicks. PMID- 4329163 TI - Role of vitamin E in the regulation of rabbit liver xanthine dehydrogenase activity. PMID- 4329166 TI - X-ray contrast presentation of the thoracic duct by enterally resorbed iodized oil emulsions in cats and dogs. PMID- 4329165 TI - [Inhibitory effect of ACTH therapy on the pituitary gland]. PMID- 4329167 TI - Immunological studies on the radiation leukaemia virus in C57BL mice. PMID- 4329168 TI - Cooperation between carrier-reactive and hapten-sensitive cells in vitro. PMID- 4329164 TI - [Steroid-induced adrenal gland hypofunction. Pathogenesis, clinical aspects, diagnosis, prevention and therapy]. PMID- 4329169 TI - Adenyl cyclase activity in cultivated human skin fibroblasts. PMID- 4329170 TI - "Mating" in Entamoeba histolytica? PMID- 4329171 TI - [Objective determination of the mineral content in the skeletons of children. Methodical and clinical problems]. PMID- 4329172 TI - [Round table discussion on bone age]. PMID- 4329173 TI - [Cervico-dorsal disk diseases. Clinico-radiological study. Pathogenetic considerations]. PMID- 4329174 TI - Herpes simplex encephalitis. PMID- 4329176 TI - Adenovirus type 7--associated encephalitis. PMID- 4329175 TI - Transplacental passage of azidocillin, ampicillin and penicillin G during early and late pregnancy. PMID- 4329178 TI - Taste pathways in rat brainstem. AB - By means of a combination of electrophysiological and anatomical procedures, the projections of the anterior portion of the solitary nucleus were traced to the parabrachial nuclei in the pons, structures hitherto not considered to be included in the taste pathway. Responses to taste stimuli were recorded from this pontine area. Lesions in the pontine taste area resulted in degeneration of fibers reaching the lingual area in the thalamus. PMID- 4329177 TI - Acquired cytomegalovirus infection in older children and adults. A clinical study of hospitalized patients. PMID- 4329179 TI - Cyclic adenosine monophosphate in brain areas: microwave irradiation as a means of tissue fixation. AB - Amounts of cyclic adenosine monophosphate in discrete regions of the brain were estimated after exposure of rats to microwave irradiation. Amounts were highest in the cerebellum and brainstem, intermediate in the hypothalamus and midbrain, and lowest in the hippocampus and cortex. Decapitation increased the concentration of cyclic adenosine monophosphate in all brain areas, although the increase in the cerebellum was three to four times greater than that in other areas. Microwave irradiation may provide a means of rapidly fixing brain tissue in situ while permitting easy dissection of the brain. In this way artifacts produced by decapitation can be eliminated, and concentrations of heat-stable compounds in the brain can be estimated under conditions which more closely approximate those in vivo. PMID- 4329180 TI - Mineral element correlation with adenohypophyseal-adrenal cortex function and stress. AB - A statistical correlationl was made between adrenocorticotropin (ACTH) and four elements in rats under control, stress, and stress-recovery conditions. Blood serum zinc showed a strong positive correlation with the rise in ACTH during stress and its decline in stress recovery. Serum calcium, copper, and magnesium demonstrated little correlation with ACTH changes. The strong ACTH-zinc correlation points to an as yet undefined interaction between ACTH and zinc PMID- 4329181 TI - Selection and preparation of patients for renal transplantation. PMID- 4329182 TI - Preservation of red cell 2,3-diphosphoglycerate in modified ACD solution and in experimental artificial storage media. PMID- 4329183 TI - [Anaphylactic shock following the administration of ACTH of a patient with bronchial asthma]. PMID- 4329185 TI - [Clinical and immunologic characteristics of pneumonia in very young children]. PMID- 4329184 TI - [Transplacental and neonatal carcinogenesis by ethylnitrosobiuret (ENBU) in BD IX rats]. PMID- 4329186 TI - [Role of Cl. perfringens types A, B, C, D, E and F in the etiology of gas gangrene]. PMID- 4329187 TI - [Study of soluble C1. perfringens type D and E antigens on tissue cultures]. PMID- 4329188 TI - Changes in the renin-angiotensin system after bilateral nephrectomy. PMID- 4329189 TI - Natriferic and hydrosmotic effect of angiotensin II in the toad Bufo paracnemis. PMID- 4329191 TI - The presence of iron and vanadium atoms in ribonucleic acid from yeast. PMID- 4329190 TI - ACTH, cyclic AMP, dexamethasone and actinomycin D effect on renin release. PMID- 4329192 TI - Studies on the mechanism of action of cyclic AMP in nervous and other tissues. PMID- 4329193 TI - Action of autonomic nerve intermediates on liver plasma membrane. PMID- 4329195 TI - An eclectic view of metabolic regulation: control of citrate synthase activity. PMID- 4329194 TI - Sub-cellular localization and characterization of DNA polymerases from rat liver and hepatomas. PMID- 4329196 TI - Enzymes in pyrimidine biosynthesis. PMID- 4329197 TI - Effects of cyclic AMP, its mechanism of action, and comments on the energetics of its 3'-phosphate bond. PMID- 4329198 TI - Control of gene expression in carbohydrate, pyrimidine and DNA metabolism. PMID- 4329199 TI - Effect of various antilipolytic compounds on adenyl cyclase and phosphodiesterase activity in isolated fat cells. PMID- 4329200 TI - The neuronal ceroid-lipofuscinoses--Batten-Vogt syndrome: a model for human aging? PMID- 4329201 TI - Aging of male Drosophila melanogaster: histological, histochemical, and ultrastructural observations. PMID- 4329202 TI - Influence of bursa of Fabricius on infection and pathological response of chickens exposed to Marek's disease herpesvirus. PMID- 4329203 TI - Pathogenesis of reticuloendothelial virus disease in chicks--an acute runting syndrome. PMID- 4329204 TI - Genetic resistance to the avian leukosis-sarcoma virus group: determining the phenotype of adult birds. PMID- 4329205 TI - Some characteristics of cell-free preparations of Marek's disease virus. PMID- 4329207 TI - Antibodies for Marek's disease virus in sera from domestic chickens and wild fowl in Kenya. PMID- 4329206 TI - Large-scale production of Marek's disease virus. PMID- 4329209 TI - Socio-economic factors in child development. PMID- 4329208 TI - Case report--studies on an unusual pox infection in turkeys. PMID- 4329210 TI - Accumulation of acetylcholine by the rat diaphragm. PMID- 4329211 TI - Effects of papaverine derivatives on cyclic AMP phosphodiesterase of human platelets. PMID- 4329212 TI - A first-order synaptic relay for taste fibers in the pontine brain stem of the cat. PMID- 4329213 TI - On the functional significance of the circuit of Papez. PMID- 4329214 TI - Spontaneous discharge of Purkinje neurons after destruction of catecholamine containing afferents by 6-hydroxydopamine. PMID- 4329215 TI - Regulation of repetitive firing in motoneurones by the afterhyperpolarization conductance. PMID- 4329216 TI - Effects of community follow-up on post-hospital adjustment of psychiatric patients. PMID- 4329217 TI - Cycloheximide resistant incorporation of amino acids into a polypeptide of the cytochrome oxidase of Neurospora crassa. PMID- 4329218 TI - Deterioration of rat-liver mitochondria during centrifugation in a sucrose gradient. PMID- 4329219 TI - From hospital to neighborhood clinic. An approach to neighborhood transfer and follow-up. PMID- 4329220 TI - [Arteriographic diagnosis of primary liver malignomas]. PMID- 4329221 TI - [Possibility of development of acneiform due to corticotropin eruptions in infancy]. PMID- 4329222 TI - [Lymphographic findings in leucosis and systemic reticulosis]. PMID- 4329223 TI - [Diagnosis and prognosis of trophoblastic tumors]. PMID- 4329224 TI - [Tissue culture technic as a possible aid in cancer prognosis (preliminary report)]. PMID- 4329225 TI - Interaction of globular actin with myosin subfragments. PMID- 4329226 TI - Renin release and utilization by the isolated perfused canine kidney. PMID- 4329227 TI - Perineal masses in male subjects. PMID- 4329228 TI - Normal respiratory parameters of unanesthetized beagle dogs. PMID- 4329229 TI - Differences between internal and external environments of the mouse cage. PMID- 4329230 TI - Studies of the delta herpesvirus isolated from the patas monkey (Erythrocebus patas). PMID- 4329231 TI - The effects of ovariectomy on pregnancy maintenance in the bitch. PMID- 4329232 TI - Use of beagle dogs in high intensity noise studies. PMID- 4329233 TI - Tumor production in squirrel monkeys (Saimiri sciureus) by Rous sarcoma virus. PMID- 4329234 TI - The ferret (Mustela putorius furo L.) as a laboratory animal. PMID- 4329235 TI - Sedation and anesthesia of the Virginia opossum, Didelphis virginiana. PMID- 4329236 TI - Hematologic values in chronic murine pneumonia. PMID- 4329237 TI - The in vitro assay of tuberculin hypersensitivity in Macaca mulatta sensitized with bacille Calmette Guerin cell wall vaccine and-or infected with virulent Mycobacterium tuberculosis. PMID- 4329239 TI - Urine collection from newborn rabbits. PMID- 4329238 TI - Shigellosis in nonhuman primates: a review. PMID- 4329240 TI - Blood viscosity, erythrocyte sedimentation rate, packed cell volume, osmolality, and plasma viscosity of the Wistar rat. PMID- 4329241 TI - Herpesvirus T as the cause of encephalitis in an owl monkey (Aotus trivirgatus). PMID- 4329242 TI - Abdominal hernias in the rhesus monkey (Macaca mulatta). PMID- 4329243 TI - Administration of test materials to the neonatal North American opossum (Didelphys marsupialis virginiana Kerr). PMID- 4329244 TI - A device for the administration of capsules and tablets to cats. PMID- 4329245 TI - Clinical laboratory values of neonatal and weanling miniature pigs. PMID- 4329246 TI - [Islet cell adenoma]. PMID- 4329247 TI - Change in methylation of 16S ribosomal RNA associated with mutation to kasugamycin resistance in Escherichia coli. PMID- 4329248 TI - In vitro relationship of SV40 tumour-specific surface antigen to other SV40 antigens. PMID- 4329250 TI - Viral infections of the skin and mouth: a selected review. PMID- 4329249 TI - Extent of transcription by the RNA-dependent DNA polymerase of Rous sarcoma virus. PMID- 4329251 TI - Identification and determination of dimethylpolysiloxanes in pharmaceutical preparations. PMID- 4329252 TI - Classical and relational psychology. PMID- 4329253 TI - An aspect of the biological basis of the mind-body apparatus: the relationship between sleep, nutritional state and mood in disorders of weight. PMID- 4329254 TI - [Histological and histochemical observations on rat kidneys following local and whole body irradiation]. PMID- 4329255 TI - On intra-uterine transport. PMID- 4329256 TI - [Auxological findings and osseous age in children with mental retardation of moderate severity]. PMID- 4329258 TI - Benign recurrent aseptic meningitis (Mollaret's meningitis). PMID- 4329257 TI - Health control of young male immigrants in Stockholm. PMID- 4329259 TI - IgM in cytomegalovirus mononucleosis. PMID- 4329260 TI - A new ACTH stimulation test using prior administration of dexamethasone and of secobarbital, and competitive protein binding estimation of plasma cortisol. PMID- 4329261 TI - The effects of infused materials upon the regeneration of newt limbs. II. Extracts from newt brain and spinal cord. PMID- 4329262 TI - Rat hindbrain thiocholine reactions relevant to the localisation of the inferior salivatory nucleus. PMID- 4329263 TI - Embryonal teratoma in double kidney. PMID- 4329264 TI - [Contribution to the question of "Cancer avec Cirrhose" (HANOT) in childhood]. PMID- 4329266 TI - Performance and fatigue in experimental double-crew transport missions. PMID- 4329267 TI - [Extrammary Paget's disease]. PMID- 4329265 TI - [Liver parenchyma lesions and portal hypertension in granulomatous hepatitis]. PMID- 4329268 TI - Experimental pseudomonas keratitis. Treatment with and evaluation of carbenicillin and gentamicin in combination. PMID- 4329270 TI - The differential laboratory adaptation of sleep parameters. PMID- 4329269 TI - Neuro-ophthalmology. PMID- 4329271 TI - The effects of iron upon the radiation damage in non-heme iron proteins. PMID- 4329272 TI - [Distribution of caffeine in animals with experimental transplantable tumors. Tests with tritium-labeled caffeine for the study of the sensitizing properties]. PMID- 4329273 TI - Pregnancy following hysterosalpingography with oil and water soluble dye. PMID- 4329274 TI - Heat stress effects during pregnancy. II. Pituitary gonadotropins in intact, adrenalectomized, and ovariectomized rats. PMID- 4329275 TI - [Interrelation of kidney and rumen purification of urea and other nitrogenous substances in sheep]. PMID- 4329276 TI - [Importance of Kaplan's hypertension testing the etiologic diagnosis of hypertension]. PMID- 4329277 TI - [Adrenocorticotropic action of synthetic polypeptides following suppression of endogenous secretion of ACTH]. PMID- 4329278 TI - [Angiotensin resistence and hyperaldosteronism with normal blood pressure]. PMID- 4329279 TI - [Renin activity in renal artery stenosis in the peripheral blood and renal vein blood in comparison with other kidney function tests]. PMID- 4329280 TI - The virus causes of coughs and colds. PMID- 4329281 TI - [Clinical aspects of virus diseases]. PMID- 4329282 TI - The preparation of brush borders from the epithelial cells of the guineapig small intestine by zonal centrifugation. PMID- 4329284 TI - A reagent for the non-destructive location of steroids and some other lipophilic materials on silica gel thin-layer chromatograms. PMID- 4329285 TI - [Separation of polysaccharides and nucleic acids by chromatography on hydroxyapatite]. PMID- 4329283 TI - Carbohydrate-rich compounds in the colonic mucosa of man. 3. A preliminary report of some biochemical characteristics of the carbohydrate-rich components in normal colonic mucosa. PMID- 4329286 TI - Proton magnetic relaxation studies of marganous complexes of transfer RNA and related compounds. PMID- 4329287 TI - An unusual condition of leucine transfer RNA appearing during leucine starvation of Escherichia coli. PMID- 4329288 TI - Differential aminoacylation of three species of isoleucine transfer RNA from Escherichia coli. PMID- 4329289 TI - The interaction of tetra-iodofluorescein with dogfish muscle lactate dehydrogenase: a chemical and x-ray crystallographic study. PMID- 4329290 TI - Adenyl cyclase activity and cyclic AMP in acute cardiac overload: a method for measuring cyclic AMP production based on ATP specific activity. PMID- 4329291 TI - Long-term isolation stress and its effects on drug response in rodents. PMID- 4329292 TI - Folic acid deficiency in the golden hamster. PMID- 4329294 TI - The Gunn rat as an animal model in comparative medicine. PMID- 4329293 TI - An epizootic of Tyzzer's disease in rabbits. PMID- 4329295 TI - Care of ground squirrels (Spermophilus spp.) in captivity. PMID- 4329296 TI - Aeromonas hydrophila infection in the Mexican axoloti, Siredon mexicanum. PMID- 4329297 TI - Pseudotuberculosis in nonhuman primates: infection with organisms of the Yersinia enterocolitica group. PMID- 4329298 TI - Laboratory diagnosis of vitamin E deficiency in rabbits fed a faulty commercial ration. PMID- 4329299 TI - Animal behavior and electromagnetic energy waves. PMID- 4329300 TI - Blood chemistry values in normal Mystromys albicaudatus and Osborne-Mendel rats. PMID- 4329302 TI - A technic for urine collection from anesthetized male rats. PMID- 4329301 TI - Armadillos: basic profiles. I. Serum chemistry values. PMID- 4329303 TI - An improved technic for the collection of bile in the unanesthetized rat. PMID- 4329304 TI - "Tek-Food," a pasteurized whole fish ration for captive marine mammals. PMID- 4329305 TI - A subcutaneous abscess associated with Salmonella typhimurium in a black howler monkey (Alouatta villosa). PMID- 4329307 TI - A respiratory mucus extractor and resuscitator for use in rodents. PMID- 4329306 TI - Serum chemistry and hematological values for axenic (germfree) and environmentally associated inbred rats. PMID- 4329308 TI - Penile hair rings in male cats may prevent mating. PMID- 4329309 TI - Renal trematodiasis in a boa constrictor (Constrictor constrictor). PMID- 4329310 TI - Hematologic values of the black spider monkey (Ateles fusciceps), red spider monkey (Ateles geoffroyi), white face monkey (Cebus capucinus), and black howler monkey (Alouatta villosa). PMID- 4329311 TI - Incidence of Shigella in conditioned rhesus monkeys (Macaca mulatta). PMID- 4329313 TI - Structure of acetylcholine. PMID- 4329312 TI - [Cytologic reaction in mice to intravenous administration of serum from patients with malignant tumors of the bladder]. PMID- 4329314 TI - Primary liver carcinoma in childhood. PMID- 4329315 TI - A neuropathy in goats caused by experimental coyotiool (Karwinskia humboldtiana) poisoning. II. Lesions in the peripheral nervous system--teased fiber and acid phosphatase studies. PMID- 4329316 TI - A neuropathy in goats caused by experimental coyotillo (Karwinskia humboldtiana) poisoning. 3. Distribution of lesions in peripheral nerves. PMID- 4329317 TI - A neuropathy in goats caused by experimental coyotiool (Karwinskia humboldtiana) poisoning. IV. Light and electron microscopic lesions in peripheral nerves. PMID- 4329318 TI - [The respiratory syncytial (RS) virus and the infections caused by it]. PMID- 4329319 TI - [Pseudo-dystrophic chronic polymyositis in children]. PMID- 4329320 TI - Menisceal tearing in pseudogout (chondrocalcinosis, pyrophosphate arthropathy). PMID- 4329321 TI - [Enzymes degrading adenosine triphosphate in human leukocytes. II. Cytochemical identification of enzymes active at pH 7.2 using the Wachstein-Meisel method]. PMID- 4329322 TI - [Importance of scintigraphy for the diagnosis of brain tumors and visual pathway lesions difficult to localize]. PMID- 4329323 TI - [Effect of hormones on bone metabolism]. PMID- 4329324 TI - [Diseases of female external genitalia. Adnexal tumors of the skin]. PMID- 4329325 TI - High phytate content of rural Iranian bread: a possible cause of human zinc deficiency. PMID- 4329326 TI - Vaccine production in human diploid cell strains. PMID- 4329327 TI - A seroepidemiologic study of adenovirus-associated virus infection in infants and children. PMID- 4329328 TI - The virus watch program: a continuing surveillance of viral infections in metropolitan New York families. IX. A comparison of infections with several respiratory pathogens in New York and New Orleans families. PMID- 4329329 TI - Cytomegalovirus infections of monkeys and baboons. PMID- 4329330 TI - Sarcomas of the soft tissues of the extremities (apropos of 17 cases). PMID- 4329332 TI - Rehabilitation of the patient with colostomy. Introductory remarks. PMID- 4329331 TI - Virological studies on an experimental minimal disease herd of pigs. PMID- 4329333 TI - Colostomy problems--dietary and colostomy management. PMID- 4329334 TI - Role of enterstomal therapists and stoma rehabilitation clinics. PMID- 4329335 TI - Association between aflatoxin content of food and hepatoma frequency in Uganda. PMID- 4329336 TI - [Melanoblastoma of the choroid in long-term cell cultures]. PMID- 4329337 TI - [Fatty acid release and hormones]. PMID- 4329338 TI - [Urinary excretion of steroid hormones in menstruation disorders and its significance]. PMID- 4329339 TI - [Ambulatory after care of patients with transplanted kidneys]. PMID- 4329340 TI - [Intratypical antigenic differences in 3 strains of parainfluenza virus-3 isolated from human blood]. PMID- 4329341 TI - Inhibition by cycloheximide and dactinomycin of the activation of lipolysis due to growth hormone in white fat cells. PMID- 4329342 TI - Effects of pesticide-grade hexanes on the silicic acid chromatography of polychlorinated biphenyls and organochlorine pesticides. PMID- 4329343 TI - Enzymatic and polarographic determination of metation and its analogues after separation on silica gel thin layers. PMID- 4329344 TI - Contact transmission of foot-and-mouth disease from infected to susceptible cattle. PMID- 4329345 TI - Variola virus and immunity in smallpox. II. Recovery of variola-specific soluble antigens from infected rhesus monkey kidney cells. PMID- 4329346 TI - Seroepidemiological studies of transfusion-associated hepatitis. PMID- 4329347 TI - Antagonism of some vascular smooth muscle agonists by histamine and betahistine. PMID- 4329348 TI - Effect of various iodic substances on the mesenteric circulation of the rat. PMID- 4329349 TI - Mechanism of host cell restriction in African green monkey kidney cells abortively infected with human adenovirus type 2. PMID- 4329350 TI - Oncogenic transformation of hamster cells after exposure to herpes simplex virus type 2. PMID- 4329351 TI - Reconstitution of a GTPase activity by a 50S ribosomal protein and E. coli. PMID- 4329352 TI - Effect of intraventricular administration of adrenergic drugs on the adrenal venous 17-hydroxycorticosteroid response to surgical stress in the dog. PMID- 4329353 TI - Pulmonary disease at necropsy after renal transplantation. PMID- 4329354 TI - [Some lymphangiographic and scintigraphic aspects after antiblastic therapy by endolymphatic route]. PMID- 4329355 TI - [Further data on the etiopathogenesis of acute leukemias in children]. PMID- 4329357 TI - Differences in the potentiation of carbon tetrachloride in rats by ethanol and isopropanol pretreatment. PMID- 4329356 TI - [Some current morphopathological aspects of infantile morbidity in Moldavia]. PMID- 4329359 TI - Myelography in the diagnosis and prognosis of brachial plexus injuries. PMID- 4329358 TI - Diet and aflatoxin B 1 toxicity in rats. PMID- 4329360 TI - Nuclear extrusion in rabbit embryos. PMID- 4329361 TI - Ultrastructural studies of the secretion of calcium carbonate by the serpulid polychaete worm, Pomatoceros caeruleus. PMID- 4329362 TI - [The pineal organ of the snake tropidonotus natrix L. II. Cytochemical, autoradiographic, and pharmacological studies]. PMID- 4329363 TI - [Ultrastructure of the olfactory epithelium of Calamoichthys calabaricus J. A. Smoth (Pisces, Brachiopterygii)]. PMID- 4329364 TI - [The taste-buds of Amiurus nebulosus (Lesueur). Morphological and histochemical investigations]. PMID- 4329365 TI - [Tumors in the region of the hand]. PMID- 4329366 TI - Recurrent aphthae. PMID- 4329367 TI - Long-term poly I:C in experimental chronic ocular herpes simplex infection. PMID- 4329368 TI - The neuropathy of multiple myeloma. An electrophysiological and histological study. PMID- 4329369 TI - Healing 'round the world. PMID- 4329370 TI - The contributions of the Nobel Prize Winners in Physiology and Medicine. PMID- 4329371 TI - Respiratory-deficient, yeastlike mutant of Mucor. PMID- 4329373 TI - Intrarenal conversion of angiotensin I to angiotensin II in the dog. PMID- 4329372 TI - Significance of splanchnic proteases in the production of a toxic factor in hemorrhagic shock. PMID- 4329375 TI - [Treatment of pancreatic endocrinopathy]. PMID- 4329376 TI - [Topics on hormones]. PMID- 4329378 TI - Hormonal effects of calcium transport in liver. PMID- 4329377 TI - Mechanism of calcification. PMID- 4329379 TI - Vitamin D: new horizons. PMID- 4329380 TI - The induction of calcium-binding protein biosynthesis by vitamin D 3 and 25 hydroxycholecalciferol. PMID- 4329382 TI - [Histochemical and electron microscopic studies on secretion kinetics of the acinar cell of the rat pancreas during fasting]. PMID- 4329381 TI - [Liver tissue cultures in experimental toxicology]. PMID- 4329383 TI - [Studies on the histogenesis of experimentally induced brain tumors. 2. Cytological findings in cell cultures]. PMID- 4329384 TI - [On mechanisms acting upon arterial blood pressure and sodium metabolism, particularly during pregnancy]. PMID- 4329386 TI - Determination of the blood content of lungs in vitro. PMID- 4329385 TI - On transmission of information by synapsis. PMID- 4329387 TI - Viral-induced fusion of human cells. II. Heterokaryocytes between human cells from different donors, and between human cells and those from other species: formation and properties. PMID- 4329388 TI - Inhibition of cellular adhesiveness by sulfhydryl blocking agents. PMID- 4329389 TI - Susceptibility of primate-mouse hybrid cells to SV40. PMID- 4329390 TI - Viral-induced fusion of human cells. I. Quantitative studies on the fusion of human diploid fibroblasts induced by Sendai virus. PMID- 4329391 TI - Non-enzymic synthesis of deoxyadenylate oligonucleotides on a polyuridylate template. PMID- 4329392 TI - Granular cell myoblastoma. PMID- 4329393 TI - Perirenal fibrous xanthoma: unusual retroperitoneal tumor. Diagnosis and treatment. PMID- 4329394 TI - Growth retardant properties of liver extract. PMID- 4329395 TI - A case of myelocytic leukemia simulating the mouse model diseases. PMID- 4329396 TI - Studies on nondefective adenovirus-simian virus 40 hybrid viruses. I. A newly characterized simian virus 40 antigen induced by the Ad2+ND 1 virus. AB - The nondefective adenovirus 2 (Ad2)-simian virus 40 (SV40) hybrid virus, Ad2(+)ND(1), does not induce heat-labile SV40 T antigen but does induce a previously uncharacterized heat-stable SV40 antigen-the SV40 "U" antigen. This antigen is detectable by both immunofluorescence and complement fixation by using sera from hamsters with SV40 tumors. Sera from hamsters bearing SV40 tumors can be divided into two groups, those that react with both SV40 T and U antigens (T(+)U(+) sera) and those that react with SV40 T antigen only (T(+)U(-) sera). SV40 U-specific sera from monkeys immunized with Ad2(+)ND(1)-infected cells do not react with SV40 T antigen by immunofluorescence but do react with an antigen in the nucleus of SV40-transformed cells and with an early, cytosine arabinoside resistant antigen present in the nucleus of SV40-infected cells. A heat-stable SV40 antigen detectable by complement fixation with T(+)U(+) hamster sera is present in extracts of SV40-induced hamster tumors and in cell packs of SV40 infected or -transformed cells. SV40 U-antigen synthesis by Ad2(+)ND(1) virus is partially sensitive to inhibitors of deoxyribonucleic acid synthesis, whereas U antigen synthesis by SV40 virus is an early cytosine arabinoside-resistant event. As an early SV40 antigen differing from SV40 T antigen, U antigen may play a role in malignant transformation mediated by SV40. PMID- 4329397 TI - Structural proteins of simian virus 40. AB - Sodium dodecyl sulfate acrylamide gel electrophoresis of the solubilized proteins from purified simian virus 40 (SV40) virions revealed two major and two minor structural polypeptide components. The major components which comprise over 75% of the total virion were shown to be the capsid proteins by immunological and isoelectric focusing fractionation analysis. These two polypeptides have estimated molecular weights of 45,000 daltons as determined by gel electrophoresis. One of the two minor components was identified as the nucleocapsid protein and has an approximate molecular weight of 16,000. The other unidentified minor component has an average molecular weight of 29,000. PMID- 4329398 TI - Deoxyribonucleic acid polymerases of Rous sarcoma virus: kinetics of deoxyribonucleic acid synthesis and specificity of the products. AB - The deoxyribonucleic acid (DNA) polymerase(s) of Rous sarcoma virus synthesizes two principal products-single-stranded DNA in the form of a DNA:ribonucleic acid (RNA) hybrid and double-stranded DNA. All of the single-stranded product and 50% of the double-stranded product can be hybridized to 70S viral RNA. These results, in combination with data obtained by analysis of the kinetics of double-stranded DNA synthesis, indicate that the synthesis of double-stranded DNA is a sequel to the synthesis of single-stranded DNA and is dependent upon the latter for the provision of initial template. PMID- 4329400 TI - Infectivity and sedimentation of rhinovirus ribonucleic acid. AB - Ribonucleic acid extracted from the virions of two human rhinoviruses is infective and is similar in size to poliovirus ribonucleic acid. PMID- 4329399 TI - Number and molecular weights of foot-and-mouth disease virus capsid proteins and the effects of maleylation. AB - Evidence was obtained by gel electrophoresis that foot-and-mouth disease virus (FMDV) type A(12) protein migrates mainly in a zone corresponding to polypeptide(s) approximately 25,000 daltons in molecular weight. Additional minor components were observed, four with molecular weights ranging from 10,000 to 22,500 daltons and one with a molecular weight of 37,500 daltons. The minor components comprised about 10% of the total protein and were present in variable amounts. The 75S empty capsids contained primarily 25,000-, 37,500- and 50,000 dalton zones. These molecular weights were estimated by polyacrylamide gel electrophoresis in sodium dodecyl sulfate versus proteins of known molecular weight, including poliovirus and vesicular stomatitis virus proteins. Maleylation of the amino residues of FMDV protein solubilized it to about 5 to 10 mg/ml in aqueous, nondenaturing solvents. This permitted molecular weights to be estimated also by gel filtration. Maleylation of 70% of the available amino groups of the FMDV protein produced heat and sodium dodecyl sulfate-stable polymeric aggregates of 10 to 20% of the 25,000-dalton zone. It also resulted in an increase in the molecular weight of this zone by an amount equivalent (ca. 1,000) to that expected from the added maleyl residues. PMID- 4329402 TI - [Determinations of the importance of IPV virus infection in breeding hygiene with reference to artificial insemination]. PMID- 4329401 TI - Some structural considerations of the reactivity of vascular smooth muscle. PMID- 4329405 TI - [Clostridium perfringens and "induced thermoresistance"]. PMID- 4329406 TI - [Detection of healthy carriers of Clostridium perfringens with thermoresistant spores in the personnel working in a food industry]. PMID- 4329407 TI - [Detection of healthy carriers of Clostridium perfringens with thermoresistant spores in the personnel working in the kitchens of two Roman hospitals]. PMID- 4329408 TI - Properties of rat liver mitochondria treated with phospholipase A and C and with lysophosphatidylcholine. PMID- 4329409 TI - The effect of stress on dreams. PMID- 4329411 TI - [Latent viral infections]. PMID- 4329410 TI - [Tumors of the lateral ventricles]. PMID- 4329412 TI - Myasthenic syndrome associated with antibiotics. PMID- 4329413 TI - Effect of central nervous system lesions in man on the direction of rapid eye movements during paradoxical sleep. PMID- 4329414 TI - Experimental studies in neuronal transmission following trauma, infarction and other metabolic disturbances. PMID- 4329415 TI - Peripheral neuropathy in long-term diphenylhydantoin therapy. PMID- 4329416 TI - Hereditary amyloid neuropathy. PMID- 4329417 TI - Some effects of deafferentation upon spinal neurons. PMID- 4329418 TI - Regional cerebral blood flow during REM and slow wave sleep. PMID- 4329419 TI - The treatment of glioblastoma multiforme. PMID- 4329420 TI - Viral induction of brain tumors in vitro. PMID- 4329421 TI - Renin in differential diagnosis of hypertension. PMID- 4329422 TI - Vagus mediated control of adrenal corticosteroid secretion in the dog. PMID- 4329423 TI - Ammonium ion, a modulator of insulin secretion. PMID- 4329424 TI - Membrane potential and mechanical tension in white and red muscles of the rat. PMID- 4329425 TI - Renin suppression by DOC and NaCl in the rat. PMID- 4329426 TI - Ligamentous strength measurements from hypophysectomized rats. PMID- 4329427 TI - Ion transport in rabbit ileal mucosa. II. Effects of cyclic 3', 5'-AMP. PMID- 4329428 TI - Adenosine 3',5'-monophosphate levels in hemorrhagic shock. PMID- 4329429 TI - Survey of interferon production and sensitivity human cell lines. AB - Seven presumed diploid and 11 established cell lines were studied for their ability to produce free interferon in response to a standardized Newcastle disease virus challenge. Interferon production was evaluated in both serum containing and serum-free medium. The ability of these cell lines to respond to the application of a standard interferon preparation by becoming resistant to virus was also examined. The diploid lines were distinctly more efficient producers of interferon than were the established lines. They also evidenced a greater requirement for serum to produce their maximum titers, but some were able to produce good titers in serum-free medium. The diploid lines were uniformly more sensitive to the application of exogenous interferon than were the established cell lines and attained greater degrees of virus resistance, but all lines tested displayed measurable sensitivity to interferon. PMID- 4329430 TI - Miniculture plaquing technique for mouse cytomegalovirus. AB - A method for plaquing mouse cytomegalovirus under agar in miniature cultures is described. Maximal virus adsorption was found to take approximately 5 hr. PMID- 4329431 TI - Growth of the IB-RS-2 pig kidney cell line in suspension culture and its susceptibility to foot-and-mouth disease virus. AB - The adaptation of the pig kidney cell line IB-RS-2, clone 60, to growth in suspension culture is described. When fully adapted, an approximate threefold increase in viable cells was obtained within 72 hr from initial cell concentrations of 5 x 10(5) per ml in culture volumes up to 1,500 ml. The monolayer cells (99th passage level) used to initiate the suspension cultures and the fully adapted suspension cells were shown to have an aneuploid chromosome karyotype, whereas earlier monolayer cultures (32nd passage level) had a pseudodiploid karyotype. Replicate virus titrations in monolayers prepared from suspension-adapted cells, IB-RS-2 monolayer cells, BHK monolayer cells, and in suckling mice showed that the suspension cells had retained sensitivity to foot and-mouth disease virus. The geometric mean peak infectivity of seven strains of foot-and-mouth disease virus grown in IB-RS-2 suspension cells was 10(8.2) plaque forming units per ml, with a mean complement-fixing activity of approximately 135 complement-fixing units per ml. These preliminary results indicate that submerged cultures of these cells on an industrial scale may be useful for commercial foot and-mouth disease vaccine production. PMID- 4329432 TI - Microtiter tests for detecting antibody in bovine serum to parainfluenza 3 virus, infectious bovine rhinotracheitis virus, and bovine virus diarrhea virus. AB - Microneutralization tests for detection of antibody in bovine serum to three bovine viruses are described. The Madin-Darby bovine kidney cell line was used with parainfluenza 3 virus (PI 3), whereas serially cultivated bovine embryonic kidney cells were used for infectious bovine rhinotracheitis virus and bovine virus diarrhea virus. Comparison of micro-hemagglutination-inhibition (HI) with micro-serum-neutralization (SN) tests for PI 3 showed the SN test to be more sensitive, more specific, and therefore more useful than the HI test for detecting antibody. Although the effect of trypsin-periodate treatment of serum was to reduce the HI titer of numerous sera by a twofold dilution, sufficient evidence could not be found to indicate that nonspecific HI inhibitors to PI 3 are present in bovine sera. PMID- 4329433 TI - Detection of foot-and-mouth disease virus antibodies. II. Use of fractionated bovine antisera for improving the specificity of a "passive" hemagglutination test. AB - Because 7S immunoglobulin (Ig) G antibodies of low type specificity were present in mixtures with highly specific 19S IgM antibodies, many bovine antisera to foot and-mouth disease virus (FMDV) type A(12), strain 119 cross-reacted with type O of FMDV and to some degree with type C in the passive hemagglutination (HA) test. After 19S IgM antibodies were separated by density gradient centrifugation or precipitated with 4% (w/v) polyethylene glycol, the antigen could be determined with "block" HA tests. Such tests used several antigen concentrations in the titration of each antiserum. Adding 4% (w/v) polyethylene glycol to the serum was especially convenient for rapid precipitation of 19S IgM antibodies for the test. Similar results were obtained with bovine 19S IgM antibodies to FMDV type O, subtype 1, strain Caseros and type C strain Rezende. PMID- 4329434 TI - Automation of a hemagglutination-inhibition test for parainfluenza 3 antibodies in bovine sera. AB - An automated hemagglutination-inhibition (HI) test for the "shipping fever" strain (SF-4) of parainfluenza 3 antibody in bovine sera was developed and compared to manual tube and microtiter test procedures. The automated system operating at 60 samples per hr provided the most test results per specified time period, and the manual tube test provided the least. The manual microtiter test and the automated system at 40 samples per hr, falling between the two above procedures, were comparable in the number of sera that could be titrated in 1 day by one technician. There was little difference between automated and manual test reproducibility when measured at the twofold titer one-dilution difference level. However, the automated system titrated a higher number of sera at the same titer on repeat runs than either of the manual test procedures. The automated one quartile difference reproducibility (each twofold dilution subdivided into 4 units-"quartiles") was equal to the manual test one-dilution difference reproducibility. The standard deviation of the per cent variation from the mean of paired serum titers for 40-sample-per-hr runs ranged from +/-3.49 to +/-5.36%. The manual and automated systems were of comparable sensitivity in their detection of negative sera. PMID- 4329435 TI - Preparation of labeled aflatoxins with high specific activities. AB - Resting cells of Aspergillus parasiticus ATCC 15517 were used to prepare highly labeled aflatoxins from labeled acetate. High synthetic activity in growing cells was evidenced only during 40 to 70 hr of incubation. Glucose was required for high incorporation efficiency, whereas the concentration of the labeled acetate determined the specific activity of the product. When labeled acetate was continuously added to maintain a concentration near but not exceeding 10 mm, in a culture containing 30 g of glucose per liter, 2% of its labels could be recovered in the purified aflatoxins which have a specific activity more than three times that of the labeled acetate. PMID- 4329436 TI - Foot-and-mouth disease virus carrier state in cells cultured from tissues of convalescent cattle. PMID- 4329437 TI - [Antibody production against poliovirus N and H antigens by immunization of guinea pigs]. PMID- 4329438 TI - Complement fixation test in the study of Australia antigen. PMID- 4329439 TI - Adsorption characteristics of foot-and-mouth disease virus selected by adsorption with homogenized calf kidney. PMID- 4329440 TI - [Significance of short-loop feedback mechanism in regulation of ACTH secretion]. PMID- 4329441 TI - [Round table discussion: on the 6th Congress of the International Thyroid Association]. PMID- 4329442 TI - [A case of palatal mixed tumor]. PMID- 4329443 TI - Genetic analysis of a gene required for the expression of allele-specific missense suppression in Saccharomyces cerevisiae. PMID- 4329444 TI - Body weight, ovarian enlargement and urinary steroids. PMID- 4329445 TI - Dose-response comparison between dexamethasone and 16-methylene-6-dehydrocortisol in the short-term suppression test. PMID- 4329446 TI - Adipose tissue lipolysis in golden hamsters with chronic hypoglycemia and hyperinsulinemia due to a transplantable islet cell tumor. PMID- 4329448 TI - Purification and physical properties of mycophage PS1. PMID- 4329447 TI - Human sarcomas in culture. Foci of altered cells and a common antigen; induction of foci and antigen in human fibroblast cultures by filtrates. AB - In a study of human sarcomas maintained in culture for periods up to two years, the following observations were made. The most prominent cell type in serially cultured osteosarcomas was fibroblastic in appearance. After 16-20 wk in culture some lines spontaneously developed foci of altered cells resembling the foci produced in monolayer cultures by oncogenic viruses. The presence of these foci in the sarcoma cultures was transient, and usually they did not reappear; but in one instance they recurred with a characteristic periodicity of several weeks. From one of the sarcoma lines, in which foci appeared after 5 months in culture, two subcultures were established from stored frozen cells and these both exhibited foci after approximately the same lapse of time. The same phenomenon has been seen with another line, suggesting that the time of appearance of foci is characteristic for particular sarcomas. Foci of similar type could sometimes be induced in monolayer cultures of human fibroblasts by filtered medium from cultured sarcomas; this bore no relation to the presence or absence of foci in the sarcoma cultures at the time the filtrate was prepared. Electron microscopy of the spontaneous and induced foci, and of the sarcoma cultures, revealed no demonstrable virus. 12 out of 15 sarcoma cultures contained an antigen (S) demonstrable by indirect immunofluorescence with human sera. It was not present in any of the original sarcoma specimens, nor in any culture lines other than sarcomas. At least 3-4 wk in culture appear to be required for its demonstration. The antigen was cytoplasmic, occurred in only a small proportion of the cells, and was unpredictably variable in its expression, even in the same culture line. It could be induced in monolayer cultures of human fibroblasts by filtrates of medium from sarcoma cultures. As with the foci, the induction of S antigen in indicator cultures was not dependent upon the expression of antigen in the sarcoma line from which the filtrates were obtained. There was no association between the presence of foci and of antigen, nor was there any apparent relation between the ability of filtrates to induce foci and their ability to induce antigen. 80% or more of the general population have S antibody, and the titer of antibody in patients with sarcoma is no higher than in normal subjects. Thus, as in the case of Burkitt's lymphoma antigen, it appears that most individuals have been exposed to S antigen. But unlike Burkitt's lymphoma, no relation has so far been established between any particular disease and a corresponding high titer or frequency of occurrence of S antibody. The occurrence of foci of altered cells and of a common antigen, and the transmission of these two characters to indicator cells by filtrates, are all suggestive of a virus specifically associated with human sarcomas, one to which the general population is widely exposed, as indicated by the prevalence of antibody. PMID- 4329449 TI - Varicella zoster virus: interferon production and comparative interferon sensitivity in human cell cultures. PMID- 4329450 TI - Preservation of lettuce necrotic yellows and some other plant viruses by dehydration with silica gel. PMID- 4329451 TI - The pharmacology of batrachotoxin. I. Effects on the contractile mechanism and on neuromuscular transmission of mammalian skeletal muscle. PMID- 4329452 TI - The pharmacology of batrachotoxin. II. Effect on electrical properties of the mammalian nerve and skeletal muscle membranes. PMID- 4329453 TI - Structural determinants of catecholamine action on in vitro insulin release. PMID- 4329454 TI - Pharmacologic and biochemical evaluation of organic nitrates: attempted correlation of activities. PMID- 4329455 TI - Influence of the carotid sinus on centrally mediated peripheral cardiovascular effects of angiotensin II. PMID- 4329456 TI - Effects of diphenhydramine and dimenhydrinate on vestibular neuronal activity of cat: a search for the locus of their antimotion sickness action. PMID- 4329457 TI - The effect of rifamycins in the ultrastructure of Anacystis montana. PMID- 4329458 TI - Intramitochondrial yolk-crystals of frog oocytes. II. Expulsion of intramitochondrial yolk-crystals to form single-membrane bound hexagonal crystalloids. PMID- 4329459 TI - Unique structures in the insect granular hemocytes. PMID- 4329460 TI - Formation of bodies associated with virus-like particles in the Amoeboflagellate Naegleria gruberi. PMID- 4329461 TI - A mitochondrial disease of leaf cells infected with an apple virus. PMID- 4329462 TI - Fine structure of transected interganglionic connectives and degenerating axons of wax moth larvae. PMID- 4329463 TI - Ultrastructural studies on prostatic involution in the rat. Mechanism of autophagy in epithelial cells, with special reference to the rough-surfaced endoplasmic reticulum. PMID- 4329464 TI - Ultrastructure of the midgut epithelial cells in the fly Calliphora erythrocephala. PMID- 4329466 TI - [Peripheral nerve compression syndrome]. PMID- 4329465 TI - [Angiography of the pancreas. Importance and indications in surgery]. PMID- 4329467 TI - [Pathological changes in organs and tissues following administration radioisotopes and contrast media]. PMID- 4329468 TI - [Fibroadenoma intracanaliculare phyllodes mammae. (Cystosarcoma phyllodes of the breast)]. PMID- 4329469 TI - [Durability of Clostridium perfringens toxins in tissue of dead animals]. PMID- 4329470 TI - Interruption of SV40 oncogenesis with human foetal antigen. PMID- 4329471 TI - Release of calcitonin from thyroid granules. PMID- 4329472 TI - [Intensivation through integration. The practice of psychiatric after care]. PMID- 4329473 TI - [Problems of pancreatic arteriography]. PMID- 4329474 TI - [Progress in the field of lymphography. Progress report]. PMID- 4329475 TI - [Complications of lipiodo lymphography]. PMID- 4329476 TI - [Experimental results with a new lipiodol emulsion (Live) for indirect and direct lymphography]. PMID- 4329477 TI - [Diagnostic problems in selective celiac arteriography with special reference to hepato-biliary tract diseases]. PMID- 4329478 TI - [Pneumoperitonium, retropneumoperitoneum and mediastinal pneumography in children]. PMID- 4329479 TI - [Basic principles of antibacterial therapy for pyelonephritis in children]. PMID- 4329481 TI - Ultrastructure of hepatic parenchyma in murine hepatosplenic bilharziasis. PMID- 4329480 TI - [Ultrastructural-morphometric study on the rat hepatocytes after cycloheximide induced protein synthesis inhibition]. PMID- 4329482 TI - Ultrastructure of the epiphyseal plate of the guinea pig in experimental scurvy. PMID- 4329483 TI - [The behaviour of Pseudomonas morsprunorum Wormald in rhizospheres under the special consideration of bacteriophages]. PMID- 4329484 TI - [Influence of bacteria upon the growth performance of higher plants under conditions of different phosphorus content of the nutrient medium and of phosphorus deficiency]. PMID- 4329485 TI - [Rare metastasis of prostatic carcinoma in the orbit]. PMID- 4329486 TI - Isolation and properties of aspergillopeptidase from Aspergillus fumigatus. PMID- 4329487 TI - Phosphodiesterase II activity against nucleoside-3' phosphate esters and some 5' O-substituted analogues; and an improved ribonuclease substrate, a-naphthyl 5'-O methyluridine-3' phosphate. PMID- 4329489 TI - Comparative sequential cytologic changes following in vitro infection with herpesvirus types I and II. PMID- 4329488 TI - -naphthyl ribonucleoside-3' phosphate analogues for the cytochemical and colorimetric assay of ribonucleases. PMID- 4329490 TI - Calcified bodies and the intrauterine device. PMID- 4329492 TI - Nerve conduction velocity in the assessment of hypertension. PMID- 4329491 TI - Salmonellosis in patients with neoplastic disease. A review of 100 episodes at Memorial Cancer Center over a 13-year period. PMID- 4329493 TI - Familial outbreak of primary herpes infection. PMID- 4329494 TI - "Gram-negative" infections of the skin. PMID- 4329495 TI - Lymphomatoid papulosis. PMID- 4329496 TI - Methaemoglobin formation by ethyl N-hydroxycarbamate and related compounds. PMID- 4329497 TI - Fat disorders and peripheral neuropathy. PMID- 4329499 TI - Picrotoxin: effect on collicular auditory neurons. PMID- 4329498 TI - Direct cortical response and PGO spike during paradoxical sleep of the cat. PMID- 4329500 TI - Suppression of inhibition in the cerebellar cortex by picrotoxin and bicuculline. PMID- 4329502 TI - Sleep research and scientific progress. PMID- 4329501 TI - Recent sleep and dream research: clinical implications. PMID- 4329503 TI - Synovial sarcoma. Electron microscopic study of a typical case. PMID- 4329504 TI - Osteosclerotic myeloma and peripheral neuropathy. A case report. PMID- 4329506 TI - Small carcinomas of the breast. PMID- 4329505 TI - Therapeutic effect and toxicity of adriamycin in patients with neoplastic disease. PMID- 4329507 TI - Argentaffin cell adenocarcinoma of the stomach: an atypical carcinoid? PMID- 4329508 TI - The effects of glucose and lithium chloride on the appearance of -1,3 glucanohydrolase activity in sand dollar plutei. PMID- 4329510 TI - The pattern of collagen degradation in cultured tadpole tissues. PMID- 4329509 TI - Diffusion-mediated control of myoblast fusion. PMID- 4329511 TI - Mitochondrial studies in senescent mice. I. Turnover of brain mitochondrial lipids. PMID- 4329513 TI - Radiation and lung cancer. PMID- 4329512 TI - Ultrastructure, fatty acid content, and metabolic activity of foam cells and other fractions separated from rabbit atherosclerotic lesions. PMID- 4329514 TI - Carcinoma of the liver. PMID- 4329515 TI - Renal medullary fibrosis in hypertension. PMID- 4329516 TI - Glucose fermentation endproducts of Erwinia spp. and other enterobacteria. PMID- 4329517 TI - Induction of nuclear envelopes around metaphase chromosomes after fusion with interphase cells. AB - The process of cellular fusion induced by Sendai virus in Chinese hamster cells (Don line) afforded us the opportunity to study nuclear envelope formation around metaphase sets in the presence of interphase nuclei, when chromosome pulverization failed to occur in such multinucleate cells. Morphologically, the enveloped metaphase chromosomes resembled a normal telophase nucleus, though minor differences prompted us to call it telophase-like. Electron microscopic observations demonstrated that the membranes enveloping the chromosomes appeared to be identical with a normal nuclear envelope. The longer the cells were incubated with Colcemid before fusion, the higher was the number of cells with telophase-like nuclei and the lower the percentage of cells with pulverizations. Furthermore, the number of pulverizations bore a somewhat direct relationship to the ratio of metaphase to interphase nuclei in multinucleate cells, and the number of telophase-like nuclei was inversely proportional to this ratio. A hypothesis is advanced in which a balance between the activities of a chromosome pulverization factor and a nuclear envelope formation factor, the former in metaphase cells and the latter in interphase cells, is decisive as to the nature of morphologic events observed in virus-induced fused cells. PMID- 4329518 TI - Reinvestigation of the fine structure of Reinke's crystal in the human testicular interstitial cell. AB - Testicular biopsy materials of men were examined with the electron microscope equipped with a tilling stage. An optical transformation method was applied for the electron microscope images. An attempt was made to clarify relationships between the contour and the internal pattern of Reinke's crystal in the interstitial cell. The shape of this crystal is a hexagonal prism. Three types of internal patterns are observed in relation to the main planes of the crystal. The crystal consists of 50-A-thick filaments. It is trigonal, a = 300 A, c = 450 A, being similar to catalase crystals studied by X-ray diffraction and electron microscopy (20), but the dimensions are different. Dislocations of Reinke's crystal are also analyzed. In some interstitial cells without Reinke's crystal, specially arranged 50-A-thick filaments are observed. They are similar in arrangement to the pattern within Reinke's crystal, but not so closely compacted. Morphological similarities and dissimilarities between this crystal and other crystal and crystalloid structures are discussed. PMID- 4329519 TI - Appearance and function of endogenous peroxidase in fetal rat thyroid. AB - Iodination within the thyroid follicle is intimately associated with a thyroid peroxidase. In order to locate the in vivo site of iodination, the initial cytochemical appearance of this enzyme has been determined in fetal rat thyroid and its presence correlated with the onset of iodinated thyroglobulin synthesis. Peroxidase first appears in follicular cells during the 18th day of gestation. It is seen first in the perinuclear cisternae, the cisternae of the endoplasmic reticulum, and within the inner few Golgi lamellae. These organelles presumably represent sites of peroxidase synthesis. During the 19th and 20th days of gestation, there is a tremendous increase in peroxidase activity. In addition to the stained sites described, there are now many peroxidase-positive apical vesicles in the follicular cells. Newly forming follicles stain most conspicuously for peroxidase, the reaction product being heavily concentrated at the external surfaces of apical microvilli and in the adjacent colloid. Iodinated thyroglobulin becomes biochemically detectable in thyroids during the 19th day of gestation and increases greatly during the 20th day. The parallel rise in peroxidase staining that just precedes, and overlaps, the rise in iodinated thyroglobulin, suggests that apical vesicles and the apical cell membrane are the major sites of iodination within the thyroid follicle. PMID- 4329520 TI - Plasma and phagosome membranes of Acanthamoeba castellanii. AB - Plasma membranes were isolated from the ameba Acanthamoeba castellanii by low speed velocity centrifugation followed by equilibrium centrifugation in a sucrose gradient. The isolated membranes had a high ratio of sterol to phospholipid (0.98 moles/mole) and of phospholipid to protein (0.43 mg/mg). The plasma membranes had very low concentrations of DNA, RNA, lipid inositol, and glycerides. Glycolipids and glycoproteins were enriched in the plasma membranes relative to their concentrations in the whole cell. The plasma membranes were also judged to be of high purity by the absence, or very low level, of enzymatic activities considered to be indicative of other cell membranes, and by electron microscope examination. Alkaline phosphatase and 5'-nucleotidase activities were enriched in the plasma membranes 13-fold relative to the whole homogenate and had higher specific activities in the plasma membranes than in any other cell fractions. A Mg(++) adenosine triphosphatase (ATPase) was enriched sixfold in the plasma membranes relative to the whole homogenate. The phospholipids of the plasma membranes contained more phosphatidylethanolamine and phosphatidylserine and less phosphatidylcholine than did the phospholipids of the whole cells. There were differences in the fatty acid compositions of corresponding phospholipids in the plasma membranes and whole cells but no difference in the ratios of total saturated to unsaturated fatty acids. The membranes of phagosomes isolated from amebae that had ingested polystyrene latex had essentially the same phospholipid, sterol, and enzymatic composition as plasma membranes. PMID- 4329521 TI - Sites of lipoprotein lipase activity in adipose tissue perfused with chylomicrons. Electron microscope cytochemical study. AB - Lipoprotein lipase activity was studied in rat parametrial adipose tissue perfused with chylomicrons and in gelatin blocks containing postheparin plasma and chylomicrons. The tissues and blocks were fixed in glutaraldehyde and incubated in 0.035 M CaCl(2)-0.1 M Tris medium (pH 8.3) at 38 degrees C. The doubly labeled chylomicron triglycerides (glycerol-(3)H and palmitate-(14)C) in the tissues and blocks were hydrolyzed during incubation to free fatty acids (FFA) and the FFA remained in the specimens; hydrolysis was inhibited by 0.004 M diethyl paranitrophenyl phosphate (E-600). Incubated blocks and tissue were treated with 0.05 M Pb(NO(3))(2), postfixed in OsO(4), dehydrated with acetone, embedded in Epon, and examined by electron microscopy. The incubated blocks contained electronlucent areas and granular and laminar precipitates at sites of hydrolysis. Similar precipitates were found in incubated tissue, within vacuoles and microvesicles of capillary endothelium, and in the subendothelial space (between the endothelium and pericytes), but not in the capillary lumen or in or near fat cells. The cytochemical reaction was greatly reduced, in blocks and tissues incubated with E-600. It is concluded that plasma glycerides are hydrolyzed by lipoprotein lipase in capillary endothelial cells and in the subendothelial space of adipose tissue and that glycerides across the endothelial cells within a membrane-bounded system. PMID- 4329522 TI - A paracrystalline inclusion in Neurospora crassa. Induction by ethidium and acridine, isolation, and characterization. AB - A paracrystal indistinguishable from the one which occurs in the mitochondrial mutant abnormal-1 can be induced in wild-type Neurospora crassa after growth in either ethidium or euflavine. This paracrystal has been isolated and partially characterized. It appears to be composed of a single polypeptide (mol wt 68,000) which can be reversibly crystallized and dissociated by changes in the pH and ionic strength. When aggregated, the polypeptide forms oligomers which are arranged end-to-end into fibers. During the characterization of the polypeptide, it was found that the polypeptide's electrophoretic and immunological properties could be used as assays. Using these methods it was found that the polypeptide normally accumulates in a soluble form in the cytoplasm of wild-type Neurospora at the end of the log-phase of growth. PMID- 4329523 TI - Elaboration of the matrix glycoprotein of enamel by the secretory ameloblasts of the rat incisor as revealed by radioautography after galactose- 3 H injection. AB - The elaboration of enamel matrix glycoprotein was investigated in secretory ameloblasts of incisor teeth in 30-40-g rats. To this end, the distribution of glycoprotein was examined histochemically by the use of phosphotungstic acid at low pH, while the formation of glycoprotein was traced radioautographically in animals sacrificed 2.5-30 min after galactose-(3)H injection. Histochemically, the presence of glycoprotein is observed in ameloblasts as well as in the enamel matrix; in ameloblasts glycoprotein occurs within the Golgi apparatus in amounts increasing from the outer to the inner face of the stacks of saccules, and is concentrated in condensing vacuoles and secretory granules; in the enamel matrix, glycoprotein is observed within linear subunits. Radioautographs at 2.5 min after injection demonstrate the uptake of galactose-(3)H label by Golgi saccules, indicating that galactose-(3)H is incorporated into glycoprotein within this organelle. After 5-10 min, the label collects in the condensing vacuoles and secretory granules of the Golgi region. By 20-30 min, the label appears in the secretory granules of the apical (Tomes') processes, as well as in the enamel matrix (next to the distal end of the apical processes, and at the tips of matrix prongs). In conclusion, galactose contributes to the formation of glycoprotein within the Golgi apparatus. The innermost saccules then distribute the completed glycoprotein to condensing vacuoles, which later evolve into secretory granules. These granules rapidly migrate to the apical processes, where they discharge their glycoprotein content to the developing enamel. PMID- 4329524 TI - Electron microscope examination of subcellular fractions. 3. Quantitative analysis of the microsomal fraction isolated from rat liver. AB - Rat liver microsomes and microsomal subfractions isolated by density equilibration were submitted to a quantitative morphological and biochemical analysis. The total area of the endoplasmic reticulum was estimated at 7.3 m(2) per g of liver. The microsome fraction contained 2.8 mg of phospholipids and 6.7 mg of proteins per m(2) of membrane area. After correction for ribosomal and intracisternal proteins, the latter value was lowered to 4.7 mg of membrane protein per m(2). More than half of the microsomal vesicles carried ribosomes. After density equilibration of the microsomes, the distribution pattern of ribosomes followed closely that of RNA. The ribosome load of the microsomal vesicles increased steadily along the density gradient, indicating the existence of a continuous spectrum of microsomal entities ranging from entirely ribosome free vesicles to vesicles heavily coated with ribosomes. PMID- 4329525 TI - Fine structure of rat intrafusal muscle fibers. The polar region. AB - An ultrastructural comparison of the two types of intrafusal muscle fibers in muscle spindles of the rat was undertaken. Discrete myofibrils with abundant interfibrillar sarcoplasm and organelles characterize the nuclear chain muscle fiber, while a continuous myofibril-like bundle with sparse interfibrillar sarcoplasm distinguishes the nuclear bag muscle fiber. Nuclear chain fibers possess well-defined and typical M bands in the center of each sarcomere, while nuclear bag fibers contain ill-defined M bands composed of two parallel thin densities in the center of the pseudo-H zone of each sarcomere. Mitochondria of nuclear chain fibers are larger and more numerous than they are in nuclear bag fibers. Mitochondria of chain fibers, in addition, often contain conspicuous dense granules, and they are frequently intimately related to elements of the sarcoplasmic reticulum (SR). Striking differences are noted in the organization and degree of development of the sarcotubular system. Nuclear bag fibers contain a poorly developed SR and T system with only occasional junctional couplings (dyads and triads). Nuclear chain fibers, in contrast, possess an unusually well developed SR and T system and a variety of multiple junctional couplings (dyads, triads, quatrads, pentads, septads). Greatly dilated SR cisternae are common features of nuclear chain fibers, often forming intimate associations with T tubules, mitochondria, and the sarcolemma. Such dilatations of the SR were not encountered in nuclear bag fibers. The functional significance of these structural findings is discussed. PMID- 4329527 TI - Prospective studies of a group of Yale University freshmen. II. Occurrence of acute respiratory infections and rubella. PMID- 4329529 TI - Clinical and histological differentiations of mucinous adenocarcinoma from colitis cystica profunda. PMID- 4329526 TI - Prospective studies of a group of Yale University freshmen. I. Occurrence of infectious mononucleosis. PMID- 4329530 TI - [Pathological immune phenomena in virus diseases]. PMID- 4329531 TI - [Diagnostic possibilities in virus diseases]. PMID- 4329528 TI - Herpes-like virus of the guinea pig: propagation in brain tissue of guinea pigs and mice. PMID- 4329532 TI - [Renovascular arterial hypertension. II. Comparison of various studies making it possible to predict the effect of surgery on hypertension. 2]. PMID- 4329533 TI - [The functional state of the adrenal cortex and lymphoid tissue reaction in thyrotoxic goiter patients]. PMID- 4329534 TI - [Mechanisms of selective increase in aldosterone secretion following activation of the renin-angiotensin system]. PMID- 4329535 TI - [Enzyme-chemical examination of the liver in experimental thyrotoxicosis]. PMID- 4329536 TI - [Regulation of the fractional composition of 11-hydroxycorticosteroids by the liver of gamma-ray irradiated dogs]. PMID- 4329537 TI - [Interrelationships between the catecholamines of the hypothalamus and the adrenocorticotropic function of the hypophysis following adrenalectomy]. PMID- 4329538 TI - [The effect of angiotensin on corticosteroid secretion]. PMID- 4329539 TI - Determination of occult invasion of bone by adjacent tumor. PMID- 4329540 TI - Effect of chemotherapy and-or head irradiation on survival of mice with intracranial glioma. PMID- 4329541 TI - Coexistence of cyst and tumor in the same kidney. PMID- 4329542 TI - [Non-secreting islet cell tumor of the pancreas]. PMID- 4329543 TI - [Classification and physiopathology of hypophyseal tumors]. PMID- 4329544 TI - [Access of sulfojodol in tuberculous caverns and bronchiectases in directed and undirected bronchography]. PMID- 4329545 TI - [Experiments on the challenge of the antivaccinial transfer immunity of cell cultures by infection with variola virus. (Evaluation of the antivariola potency of smallpox vaccines)]. PMID- 4329546 TI - [Compression of the deep branch of the radial nerve in patients with rheumatoid arthritis]. PMID- 4329547 TI - Factors affecting plaque assay of animal viruses--with special reference to vesicular stomatitis and vaccinia virus. PMID- 4329548 TI - [Changes of nucleic acids and mitochondrial enzymes in experimental leishmaniasis]. PMID- 4329550 TI - [Developmental age and arterial blood pressure in boys]. PMID- 4329549 TI - The pathophysiology of cholera. PMID- 4329551 TI - The effect of testosterone on the age-associated changes in the ventral prostate gland of the mouse. Testosterone and ageing of the prostate. PMID- 4329552 TI - Effect of vitamin D 3 and induced calciphylaxis on atherosclerosis of rabbits treated with cholesterol and calcium gluconate. PMID- 4329554 TI - Operational definition of the hormone. PMID- 4329553 TI - A comparison of alcoholic pancreatitis in rat and man. AB - Acute ethanol intoxication was studied in 38 Wistar rats, 18 on a balanced diet and 20 on a high fat diet, fed by gavage on 47% ethanol in a dosage of from 3 to 12 g/kg body weight daily for periods ranging from three to 16 days. No macroscopic changes in pancreas or liver were found in any of these animals. Histological changes (venous congestion of the pancreas, the liver, and the kidneys) were found in rats given 4 g or more per kilogram. The only difference between the findings in rats given a balanced diet and those given a high fat diet was the development of fatty livers in the latter group. Chronic ethanol intoxication was studied in 45 Wistar rats, on a balanced diet, which were given 20% ethanol freely for 20 to 30 months. More than half the animals developed pancreatic lesions very similar to those of human chronic pancreatitis. The pathological changes, in foci surrounded by normal pancreatic tissue, were a reduction in acini, duct multiplication (probably by neogenesis), protein plugs, sometimes calcified in the ducts and sclerosis. Samples of pancreatic juice from four animals exposed to ethanol contained significantly higher protein concentrations than samples taken from two control animals. Protein precipitates appeared spontaneously in the pancreatic juice of the animals exposed to ethanol, but not in that of the controls. These findings are very similar to those in alcoholic pancreatitis in man, which has thus been reproduced for the first time in experimental animals. Beta-cell adenomata of the islets of Langerhans were observed in four of the rats exposed to ethanol. PMID- 4329555 TI - Secondary hyperaldosteronism caused by cervical phaeochromocytoma cured by ablation of the tumor. PMID- 4329556 TI - The preparation and properties of macrophage-L cell hybrids. AB - The plasma membrane of the mouse peritoneal macrophage has specific receptors which enable the cell to bind IgG or complement-coated sheep red cells and is also rich in a divalent cation-dependent adenosine triphosphatase (ATPase) activity. L cells lack these macrophage membrane markers. The question of macrophage membrane receptor expression was investigated in DBA/2 mouse macrophage x mouse LMTK(-) cell hybrids produced with the aid of Sendai virus. Three independent clones and one mass culture were isolated by their ability to grow in hypoxanthine, aminopterin, and thymidine (HAT) selection medium. These hybrids retained 85-100% of the sum of two parent cells' chromosomes and expressed several genes derived from both parents, including glucose phosphate isomerase isozymes and H-2 antigens. The hybrids displayed ATPase activity which was intermediate between that of the macrophage and L cell. The macrophage specific receptors for antibody or complement-coated red cells could not be demonstrated on hybrid cells. The selective absence of these receptors is probably because of a failure in gene expression rather than to loss of genes. PMID- 4329557 TI - Neurological manifestations in adult steatorrhoea (probable Gluten enteropathy). PMID- 4329558 TI - The action of a GABA derivative in human spasticity. PMID- 4329559 TI - Inactivation of T antigen-forming capacites of simian virus 40 and adenovirus 12 by ultraviolet irradiation. AB - Methods to measure T antigen-forming capacities of simian virus 40 (SV40) and adenovirus 12 (Ad12) were investigated, and a method to measure the capacity in terms of T antigen-forming units was employed by the use of cytosine arabinoside. Plaque-forming units and T antigen-forming units of SV40, SV40 deoxyribonucleic acid, or Ad12 were inactivated by ultraviolet (UV) irradiation at the same rate, roughly following a single-hit curve. T-antigen formation by UV-irradiated SV40 and Ad12 was enhanced in cells multiply infected and in cells in a growing state. These observations showed that it was difficult or impossible to estimate the size of the gene for T antigen by UV inactivation. PMID- 4329560 TI - Characterization of the genome of cytoplasmic polyhedrosis virus. AB - It is possible to oxidize in situ the 3'-terminals of the double-stranded ribonucleic acid (RNA) contained in structurally intact cytoplasmic polyhedrosis virus. The number of 3'-terminals subsequently found by reduction with tritiated sodium borohydride was equivalent to the number observed in RNA first isolated from the virus and then oxidized and reduced. The viral RNA appears to occur in 10 distinct polynucleotide segments present in equimolar amounts. PMID- 4329561 TI - Virus protein synthesis in animal cell-free systems: nature of the products synthesized in resonse to ribonucleic acid of encephalomyocarditis virus. AB - Ribonucleic acid (RNA) from encephalomyocarditis (EMC) virus stimulates the incorporation of amino acids into protein in cell-free protein-synthetic systems derived from Krebs mouse ascites tumor cells and chick embryo fibroblasts; the mouse system is the more responsive to the viral RNA. The greater part of this difference in activity can be ascribed to the cell sap, but the origin of the ribosomes also has a marked effect. The nature of the polypeptides formed in these cell-free systems was investigated by electrophoresis on polyacrylamide gels and by fingerprint analysis of tryptic digests. The same product in part appears to be synthesized in response to the EMC RNA in both systems. It was not detected if the EMC RNA was partly degraded ( 1.21. In all samples, almost all (mean 94%) of the radioactivity was found in association with proteins of d > 1.21. This observation was confirmed by bioassay, measuring uptake of (45)Ca by intestinal slices. All plasma bioassayable vitamin D was found in association with proteins of d > 1.21; 55% of bioactivity was found in the chromatographic fraction corresponding to 25-hydroxycholecalciferol and 44% in the fractions representing vitamin D(3). Since both vitamin D(3) and its 25-hydroxy metabolite are lipid soluble sterol derivatives, the finding that these compounds do not circulate in association with the known plasma lipoproteins provides presumptive evidence for the existence of a specific transport protein of d > 1.21. The transport protein for the polar metabolite has been partly characterized by gel filtration on Sephadex G-200 and by electrophoresis on polyacrylamide gel. The protein has an apparent size slightly smaller than plasma albumin (approximate mol wt 50,000 60,000) and an electrophoretic mobility very slightly greater than that of albumin. Studies are in progress to fractionate further and to characterize the transport protein. PMID- 4330007 TI - Effect of thyrotropin-releasing factor on serum thyroid-stimulating hormone. An approach to distinguishing hypothalamic from pituitary forms of idiopathic hypopituitary dwarfism. AB - To test the hypothesis that the primary defect in some patients with idiopathic hypopituitary dwarfism is failure to secrete hypothalamic hypophysiotropic releasing factors, synthetic thyrotropin-releasing factor (TRF), 500 mug, wa given intravenously, and timed venous samples obtained for determination of the concentration of plasma TSH by radioimmunoassay in three groups of subjects: (a) 11 patients without evidence of endocrine or systemic disease, (group I) (b) 8 with isolated growth hormone deficiency and normal thyroid function, (group II) and (c) 9 patients with idiopathic hypopituitary dwarfism and thyroid-stimulating hormone (TSH) deficiency (group III). The mean fasting plasma TSH value was 4.1 muU/ml in group I, and 3.9 muU/ml in group II; in both groups there was a brisk rise in plasma TSH to peak levels of 12-45 muU/ml at 30-45 min, and a fall toward base line levels at 120 min. All children in group III had basal TSH levels of < 1.5 muU/ml; one failed to respond to TRF; eight exhibited a rise in plasma TSH with peak values comparable with those in groups I and II. In four of eight children in group III who responded to TRF, the TSH response was delayed and the initial rise in plasma TSH was not detectable until 10-60 min. In these four patients, plasma TSH levels continued to rise at 120 min. The mean fasting concentration of plasma thyroxine iodide (T(4)) in subjects with normal thyroid function (groups I and II) was 5.6 mug/100 ml, and the mean plasma T(4) level at 120 min was 6.6 mug/100 ml. This difference between fasting and postTRF plasma T(4) was significant (P < 0.001) by paired analysis. Mean fasting plasma T(4) concentration in group III patients was 1.3 mug/100 ml; after TRF a significant rise in T(4) concentration was not detected in this group. The results indicate that TRF test is useful in distinguishing between primary hypothalamic and pituitary forms of TSH deficiency. In light of the evidence of TRF deficiency in eight of nine patients with idiopathic hypopituitary dwarfism, it seems likely that in these patients, other pituitary hormone deficiencies may be attributable to deficiency of their respective releasing factors. PMID- 4330008 TI - [Bronchial asthma and anti-inflammatory steroid]. PMID- 4330009 TI - Nucleoside peptides. 2. Synthesis of certain 5-N-aminoacyl and 5-N-peptidyl derivatives of 5-aminouridine. PMID- 4330010 TI - Inhibition of electron transport by substituted salicyl-N-(n-octadecyl)amides. PMID- 4330011 TI - 8-substituted theophyllines. In vitro inhibition of 3',5'-cyclic adenosine monophosphate phosphodiesterase and pharmacological spectrum in mice. PMID- 4330012 TI - Antimicrobials. 1. Benzothiazolylbenzylamines. PMID- 4330013 TI - Antimicrobials. 2. Substituted benzothiazolylbenzylamines and related compounds. PMID- 4330014 TI - Antimicrobials. 3. Benzothiazolylphenylalkylamines. PMID- 4330015 TI - Studies of the immune respnse in Sendai virus infection of mice. PMID- 4330016 TI - Alan Watson Gledhill. 4 June 1910--20 July 1967. PMID- 4330017 TI - [Pelvic arteriography in gynecologic and obstetrical pathology]. PMID- 4330018 TI - Adenocarcinoma in a diverticulum of the female urethra: a case report of mucous adenocarcinoma with a summary of the literature. PMID- 4330021 TI - Electron microscopic study of rhinovirus replication in human fetal lung cells. PMID- 4330020 TI - Bilateral Wilms tumor: 4-year survival. PMID- 4330019 TI - Evaluation of an intraurethral lubricating catheter in prevention of catheter induced urinary tract infections. PMID- 4330023 TI - Purified K-agglutinogen of Bordetella pertussis and its properties. PMID- 4330022 TI - Biochemical and immunological studies on Aspergillus. 3. Chemical and immunological properties of glycopeptide obtained from Aspergillus fumigatus. PMID- 4330024 TI - Ultraviolet inactivation of the capacity to induce karyotypic changes by hemadsorption type 2 virus. PMID- 4330025 TI - Organization of physiological parameters in normal and neurologically abnormal infants. PMID- 4330026 TI - Vestibulo-ocular response and its state dependency in newborn infants. PMID- 4330027 TI - Brain and behavioural maturation in newborn infants of diabetic mothers. I. Nerve conduction and EEG patterns. PMID- 4330028 TI - Brain and behavioural maturation in newborn infants of diabetic mothers. II. Sleep cycles. PMID- 4330029 TI - Alterations of the sleep cycle in heroin-addicted and "suspect" newborns. PMID- 4330030 TI - Psychiatric aftercare including home visits. PMID- 4330031 TI - [Surgical aspects of coexistent pulmonary tuberculosis and carcinoma]. PMID- 4330032 TI - [Trial of electronystagmographic localization of peripheral and central lesions of the vestibular apparatus]. PMID- 4330034 TI - Cholesterol and cancer. PMID- 4330035 TI - Progress report on the treatment of Cushing's disease. PMID- 4330036 TI - Dilantin and metyrapone: a clinically significant example of enzyme induction. PMID- 4330038 TI - Studies of tumor antigens and tumor-specific immune mechanisms in experimental systems. PMID- 4330037 TI - Responses of capacitance vessels to physiologic stimuli. PMID- 4330040 TI - Evidence for a new kidney-produced hormone, 1,25-dihydroxycholecalciferol, the proposed biologically active form of vitamin D. PMID- 4330039 TI - [Current trends in chemotherapy of neoplasms]. PMID- 4330041 TI - [Epithelioma with changes of the stroma of the buccal cavity. Apropos of 5 cases]. PMID- 4330042 TI - Development of terminal deoxynucleotidyl transferase activity in embryonic calf thymus gland. PMID- 4330043 TI - Mammalian collagenase: direct demonstration in homogenates of involuting rat uterus. PMID- 4330044 TI - Effect of a transaminase inhibitor on the transport of cytosolic reducing equivalents into mitochondria. PMID- 4330045 TI - Replication of Rous sarcoma virus and the biosynthesis of the oncogenic subviral ribonucleoprotein particles ("virosomes") in the mitochondria isolated from Rous sarcoma tissue. PMID- 4330046 TI - Purification of neuraminidases from Vibrio Cholerae, Clostridium Perfringens and influenza virus by affinity chromatography. PMID- 4330047 TI - Oxidative phosphorylation in Pseudomonas saccharophilia under autotrophic and heterotrophic growth conditions. PMID- 4330048 TI - Rat liver non-histone proteins: correlation between protein kinase activity and activation of RNA synthesis. PMID- 4330049 TI - Identification of insulin binding activity and isolation of endogenous insulin from rat liver. PMID- 4330050 TI - Effects of chaotropic agents on the spectroscopic properties of spinach ferredoxin. PMID- 4330051 TI - The dissociation of Yoshida hepatoma ribosomes into active particles. AB - 1. The sedimentation pattern of Yoshida hepatoma ribosomes shows mainly a high dimer peak and an intermediate peak between those of monomer and dimer. 2. The treatment of the postmitochondrial supernatant with EDTA or potassium chloride leads to the dissociation of ribosomes into subunits, through a decrease ofthe ribosomal Mg(2+)/phosphorus ratio. Provided that the deprivation of endogenous Mg(2+) is not complete, the subunits reassociate into active polyribosomes after addition of magnesium chloride to the medium. If the Mg(2+)/phosphorus ratio is lowered below 0.01 (mumol/mumol), structural changes occur, that become evident by a loss of protein and by a decreased sedimentation rate, which render the subribosomal particles unable to reassociate. 3. In the re-formation of polyribosomes from subunits, during the progressive increase of the concentration of magnesium chloride in the medium, the formation of monomeric ribosomes seems to be intermediate. 4. A dimerization of monomers and subunits occurs at concentrations of magnesium chloride greater than those required for the re formation of polyribosomes and a preincubation for 1h at 0 degrees C is necessary for the maximum dimerization, whereas the complete reconstitution of polyribosomes is immediate. PMID- 4330052 TI - A quantitative investigation of the phospholipid-dependence of rat liver microsomal glucose 6-phosphohydrolase. PMID- 4330054 TI - Spin labeling studies of D-glyceraldehyde-3-phosphate dehydrogenase. PMID- 4330053 TI - [Spontaneous eye movement caused by brain lesions]. PMID- 4330056 TI - Synthetic polynucleotides. Ther terminal addition of riboadenylic acid to deoxyoligonucleotides by terminal deoxynucleotidyl transferase as a tool for the specific labelling of deoxyoligonucleotides at the 3'-ends. PMID- 4330055 TI - Studies on the biosynthesis of NAD from nicotinamide and on the intracellular pyridine nucleotide cycle in isolated perfused rat liver. PMID- 4330057 TI - [Electron microscopy of liver mitochondria from intact and tumor-bearing rats]. PMID- 4330058 TI - An analysis of the electron paramagnetic resonance spectrum of pseudomonas oleovorans rubredoxin. A method for determination of the liganids of ferric iron in completely rhombic sites. PMID- 4330059 TI - Insulin-like effect of clostridial phospholipase C, neuraminidase, and other bacterial factors on brown fat cells. PMID- 4330060 TI - Kinetic studies of the prolyl transfer ribonucleic acid synthetase of Escherichia coli. Order of addition of substrates and release of products. PMID- 4330061 TI - Ferredoxin-activated fructose diphosphatase of spinach chloroplasts. Resolution of the system, properties of the alkaline fructose diphosphatase component, and physiological significance of the ferredoxin-linked activation. PMID- 4330062 TI - Electron paramagnetic resonance studies at temperatures below 77 degrees K on iron-sulfur proteins of yeast and bovine heart submitochondrial particles. PMID- 4330063 TI - Respiration-driven proton transport in submitochondrial particles. PMID- 4330064 TI - Electron paramagnetic resonance and proton relaxation rate studies of spin labeled creatine kinase and its complexes. PMID- 4330065 TI - Magnetic resonance studies of the interaction of spin-labeled creatine kinase with paramagnetic manganese-substrate complexes. PMID- 4330066 TI - Aqueous estrogens in the management of respiratory distress syndrome. PMID- 4330067 TI - Experimental infection with Pseudomonas aeruginosa in mice. I. The virulence of Pseudomonas aeruginosa for mice. PMID- 4330068 TI - DNA-dependent in vitro synthesis of enzymes of the galactose operon of Escherichia coli. PMID- 4330069 TI - Cytostatic antibody and SV40 tumour immunity in hamsters. PMID- 4330070 TI - New porous biomaterials by replication of echinoderm skeletal microstructures. PMID- 4330071 TI - Expression of differentiated functions in mouse neuroblastoma mediated by dibutyryl-cyclic adenosine monophosphate. PMID- 4330072 TI - Leukaemia virus-induced alteration of leucocyte migration in vitro. PMID- 4330073 TI - Covalently linked RNA-DNA molecule as initial product of RNA tumour virus DNA polymerase. PMID- 4330074 TI - Protein kinase and phosphate acceptor proteins in Rauscher murine leukaemia virus. PMID- 4330076 TI - [Results of treatment of flexion spasms in children]. PMID- 4330077 TI - [Abnormal ramification of the bile duct mesh in liver biopsies]. PMID- 4330078 TI - [Epithelium of the tubes in correlation with histological findings in the endometrium and ovary]. PMID- 4330075 TI - Hormone-activated expression of the C-type RNA tumour virus genome. PMID- 4330080 TI - [Laredo-type strains of Entamoeba histolytica]. PMID- 4330079 TI - A histopathologic survey of Galago in captivity. PMID- 4330081 TI - [The diagnosis and treatment of cylindromas of the ethmoid labyrinth]. PMID- 4330082 TI - [Serologic indices of viral and streptococcal infection in angina among adults]. PMID- 4330084 TI - Sleep and disease. PMID- 4330083 TI - [A tumor of the jugular glomus with intracranial growth]. PMID- 4330085 TI - The incidence of novelty in dreams. PMID- 4330086 TI - Effects of dextroamphetamine sulfate on EEG sleep patterns of hyperactive children. PMID- 4330087 TI - Regulation of gluconeogenesis during exposure of young rats to hypoxic conditions. AB - 1. Two-day-old rats were exposed at constant temperature to atmospheres containing air and nitrogen with the air content varied in steps from 100 to 0%. By using this system of graded hypoxia a comparison was made between rates of gluconeogenesis from lactate, serine and aspartate in the whole animal and the concentrations of several liver metabolites. 2. Gluconeogenesis, expressed as the percentage incorporation of labelled isotope into glucose plus glycogen, proceeds linearly for 30min when the animals are incubated in a normal air atmosphere, but is completely suppressed if the atmosphere is 100% nitrogen. 3. Preincubation of animals for between 5 and 30min under an atmosphere containing 19% air results in the attainment of a new steady state with respect to gluconeogenesis and hepatic concentrations of ATP, ADP, AMP, lactate, pyruvate, beta-hydroxybutyrate and acetoacetate. 4. When lactate (100mumol), aspartate (20mumol) or serine (20mumol) was injected, it was shown that the more severe the hypoxia the greater the depression of gluconeogenesis. Under conditions when gluconeogenesis was markedly inhibited there were no changes in the degree of phosphorylation of hepatic adenine nucleotides, but free [NAD(+)]/[NADH] ratios fell in both cytosol and mitochondrial compartments of the liver cell. 5. Measurements of total liver NAD(+) and NADH showed that the concentrations of these nucleotide coenzymes changed less with anoxia, in comparison with the concentration ratio of free coenzymes. 6. Calculations showed that the difference in NAD(+)-NADH redox potentials between mitochondrial and cytosol compartments increased with the severity of hypoxia. 7. From the constancy of the concentrations of adenine nucleotides it is concluded that liver of hypoxic rats can conserve ATP by lowering the rate of ATP utilization for gluconeogenesis. Gluconeogenesis may be regulated in turn by the changes in mitochondrial and cytosol redox state. PMID- 4330088 TI - The influence on platelet aggregation of drugs that affect the accumulation of adenosine 3':5'-cyclic monophosphate in platelets. AB - 1. The involvement of intracellular 3':5'-cyclic AMP in the inhibition of platelet aggregation by prostaglandin E(1), isoprenaline and adenosine has been examined by a radiochemical technique. Platelet-rich plasma was incubated with radioactive adenine to incorporate (14)C radioactivity into platelet nucleotides. Pairs of identically treated samples were taken, one for the photometric measurement of platelet aggregation induced by ADP, the other for estimation of the radioactivity of 3':5'-cyclic AMP. 2. Theophylline, papaverine, dipyridamole and 2,6-bis-(diethanolamino)-4-piperidinopyrimido[5,4d]pyrimidine (compound RA233) were found to inhibit 3':5'-cyclic AMP phosphodiesterase from platelets. At concentrations of 3':5'-cyclic AMP greater than 50mum the most active inhibitor was dipyridamole; at 3':5'-cyclic AMP concentrations less than 19mum, papaverine and compound RA233 were more active than dipyridamole. 3. In the presence of compound RA233 (50mum), the effectiveness of prostaglandin E(1) as an inhibitor of platelet aggregation was increased tenfold. Compound RA233 also increased the stimulation by prostaglandin E(1) of the incorporation of radioactivity into 3':5'-cyclic AMP. 4. Compound RA233 (50mum) increased the effectiveness of both adenosine and 2-chloroadenosine as inhibitors of aggregation by 70-100-fold, and in the presence of compound RA233 both adenosine and 2-chloroadenosine stimulated the incorporation of radioactivity into 3':5' cyclic AMP; the extent of the stimulation was proportional to the logarithm of the nucleoside concentration. 5. Compound RA233 (100-500mum) inhibited platelet aggregation by itself and caused small increases in the radioactivity of 3':5' cyclic AMP. Partial positive correlations were found between the radioactivity of 3':5'-cyclic AMP in platelets measured at the time of addition of the aggregating agent (ADP) and the extent to which the aggregation was inhibited. 6. The results are interpreted as indicating that adenosine, 2-chloroadenosine, isoprenaline, prostaglandin E(1) and drugs that inhibit platelet 3':5'-cyclic AMP phosphodiesterase all inhibit aggregation by a common mechanism involving intracellular 3':5'-cyclic AMP. PMID- 4330089 TI - Transient-kinetic studies of pig muscle lactate dehydrogenase. AB - 1. The very fast pre-steady-state formation of NADH catalysed by pig M(4) lactate dehydrogenase was equivalent to the enzyme-site concentration at pH values greater than 8.0 and to one-half the site concentration at pH6.8. 2. The rate of dissociation of NADH from the enzyme at pH8.0 (450s(-1)) in the absence of other substrates is faster than the steady-state oxidation of lactate (80s(-1)). The latter process is therefore controlled by a step before NADH dissociation but subsequent to the hydride transfer. 3. The oxidation of enzyme-NADH by excess of pyruvate was studied as a first-order process at pH9.0. There was no effect of NADD on this reaction and it was concluded that the ternary complex undergoes a rate-limiting change before the hydride-transfer step. 4. Some conclusions about the reactions catalysed by the M(4) isoenzyme were drawn from a comparison of these results with those obtained with the H(4) isoenzyme and liver alcohol dehydrogenase. PMID- 4330090 TI - A radiochemical renin assay. AB - 1. A synthetic 3-([(14)C]valine)-labelled tetradecapeptide renin substrate was used to measure renin concentration. Renin liberated (14)C-labelled angiotensin I, which was separated from the labelled substrate by paper chromatography. The conversion of substrate into angiotensin I was quantitated by liquid scintillation counting of radioactivity. 2. The rate of conversion of the substrate into angiotensin I was shown to be linearly related to renin concentration and time under suitable conditions. Angiotensin generation measured in this system agrees well with that measured by bioassay. 3. It is suggested that the use of a pure substrate offers advantages that include the standardization of current units of renin measurement. PMID- 4330091 TI - Polyribosomal attachment to rat liver and hepatoma endoplasmic reticulum in vitro. A method for its study. AB - A system for study and measurement of the attachment in vitro of exogenous polyribosomes to membranes has been presented. Its main features are use of low temperature, post-microsomal supernatant, pyrophosphate and citric acid to remove ribosomes from the surface of rough endoplasmic reticulum, and a method for quantitative separation of unattached from membrane-associated polyribosomes. The following were found. (1) Rough endoplasmic reticulum, from which ribosomes had been removed by treatment with pyrophosphate and citrate, bound over 50% of added polyribosomes, whereas the untreated (or control) rough and smooth endoplasmic reticulum and the smooth endoplasmic reticulum treated with pyrophosphate-citrate did not bind polyribosomes. (2) The polyribosome-binding capacity of rough endoplasmic reticulum stripped of its ribosomes decayed upon storage of the membranes at 0-4 degrees C. The half-life of this decay was about 6 days whereas that of the polyribosome-binding capacity of hepatoma stripped rough endoplasmic reticulum was about 1.5 days. (3) Preparations of stripped rough endoplasmic reticulum after reassociation with polyribosomes in vitro were quite similar to preparations of native rough endoplasmic reticulum as viewed with the electron microscope. Evidence is presented to support the contention that association of polyribosomes with membranes was the result of polyribosomal reattachment to the membranes rather than trapping of the polyribosomes between vesicles of the membranes. PMID- 4330092 TI - Mitochondrial development in liver of foetal and newborn rats. AB - THE DEVELOPMENT OF THE INNER MITOCHONDRIAL MEMBRANE IN FOETAL AND NEONATAL RAT LIVER WAS STUDIED BY FOLLOWING THREE PARAMETERS: (1) the activity of several respiratory enzymes in homogenates and purified mitochondria, (2) the spectrophotometric determination of cytochrome content in the mitochondria and (3) the cardiolipin content in both homogenates and purified mitochondria. Respiratory-enzyme activities of homogenates of foetal liver were one-quarter to one-twentieth of those of homogenates of adult liver, and the enzyme specific activities in purified mitochondria from foetal liver were one-half to one-eighth of those in mitochondria from adult liver. The cardiolipin content of liver homogenates increased approximately twofold during the development period, but there was no significant change in the cardiolipin content of purified mitochondria. It is concluded that cell mitochondrial content approximately doubles in the immediate postnatal period. There was no evidence for an increase in the relative amount of cristae protein in mitochondria during this period to account for increases in mitochondrial enzyme specific activity, since cardiolipin and cytochrome concentrations remained unchanged and electron micrographs revealed no differences. The cause of the lower respiratory-enzyme specific activity in foetal liver mitochondria is unclear. Qualitative differences in respiratory units in foetal and mature animals are suggested. PMID- 4330093 TI - [Study of a case of arrhenoblastoma (with ultrastructural examination)]. PMID- 4330095 TI - The myotonic discharge in various neurological syndromes: a neurophysiological analysis. PMID- 4330094 TI - [Effect of parathormone on the bone metabolism and the importance of laboratory diagnosis parameters in the diagnosis of hyperparathyroidism]. PMID- 4330096 TI - Electron microscopical study of neuroaxonal dystrophy. Case report. PMID- 4330097 TI - [Beta receptors and bronchial asthma]. PMID- 4330098 TI - [Pneumocholecystitis]. PMID- 4330099 TI - A mixed longitudinal study on skeletal maturation in healthy Finnish children aged 5 to 10 years. PMID- 4330100 TI - Synthesis of (+)-and (-)-7-oxaprostaglandin F 1 and their 15-epimers. PMID- 4330101 TI - Peripheral nerve entrapment syndromes in the foot. PMID- 4330102 TI - Synovial sarcoma of the foot. A case report. PMID- 4330103 TI - Role of lysosomal enzymes in adaptation to simulated high altitude by myocardium subject to the effects of acute aortic stenosis or isoproterenol. PMID- 4330104 TI - The phospholipids of corynebacteria. PMID- 4330105 TI - Deposition of cyclopropenoids in the tissue lipids of rainbow trout fed methyl sterculate. PMID- 4330107 TI - [Immunological study of cerebral tumors in vitro]. PMID- 4330106 TI - A possible block in the intermediary metabolism of glucose into proteins and lipids in the brains of undernourished rats. PMID- 4330108 TI - Infections of the hand. PMID- 4330109 TI - Management of rheumatoid arthritis in the surgical patient. PMID- 4330110 TI - Diagnosis of left upper quadrant masses by multiple organ scans. PMID- 4330111 TI - Suppression of adrenal glands by ovarian hormones in gonadotrophin-treated immature rats. PMID- 4330112 TI - [Cytomorphological study of cuttle-fish ovarian follicles. II. Secretory function of the follicular epithelium]. PMID- 4330113 TI - [Experiences with 99m Technetium-Iron(II)-complex in the brain scintigraphy]. PMID- 4330115 TI - Effect of RNA extracted from a neoplastic cell line on lymphocyte cultures. PMID- 4330114 TI - Paper chromatographic separation and determination of nucleoside phosphates in acidic rat tissue extracts. PMID- 4330116 TI - [Association of aneurysm of the anterior cerebral artery and pituitary eosinophilic adenoma. Utility bilateral carotid arteriography]. PMID- 4330118 TI - Oral contraceptives and the skin. PMID- 4330117 TI - [Effect of physical exercise on glutamic acid metabolism in rat brain tissue]. PMID- 4330119 TI - Joint fluid analysis. PMID- 4330120 TI - Therapy for carcinoma of the liver. PMID- 4330121 TI - The role of selective angiography in evaluation of hepatomas. PMID- 4330122 TI - [Virological study of fatal cases of paralytic poliomyelitis. II. Isolation of poliovirus from cerebrospinal fluid (postmortem)]. PMID- 4330125 TI - Oxygen binding of hemerythrin. PMID- 4330124 TI - [History of the campaign against major endemic diseases on the Ivory Coast]. PMID- 4330123 TI - [Enterovirus flora in normal children (preliminary report)]. PMID- 4330126 TI - Fluorescence changes associated with denaturation of alcohol dehydrogenase. PMID- 4330127 TI - Ribulose-5-phosphate kinase from Chromatium sp. strain D. PMID- 4330129 TI - Characterization of vitamin K from pig liver and dog liver. PMID- 4330128 TI - Distribution of cholesterol side-chain cleavage and 11 -hydroxylase in the mitochondria of bovine adrenal cortex: release by phospholipase A. PMID- 4330130 TI - Purification and regulatory properties of beef liver D-glycerate dehydrogenase. PMID- 4330131 TI - Effects of 3'deoxyadenosine (cordycepin) and 2'deoxyadenosine on nucleoside transport, macromolecular synthesis, and replication of cultured Novikoff hepatoma cells. PMID- 4330132 TI - Sarcoplasmic reticulum. XII. The interaction of 8-anilino-1-naphthalene sulfonate with skeletal muscle microsomes. PMID- 4330133 TI - Production of epinephrine-induced skin lesions and fever following local and systemic injections of herpes simplex and vesicular stomatitis viruses in the rabbit. PMID- 4330134 TI - Serological comparison among various strains of equine infectious anemia virus. PMID- 4330135 TI - Effect of various methods of removing non-specific inhibitors to virus hemagglutination upon serum proteins and immunoglobulins. PMID- 4330136 TI - Effect of polyionic compounds on the plating efficiency of some strains of vesicular stomatitis virus. PMID- 4330137 TI - [Antiviral activity of imidazole derivates. 3. Autoradiographic studies on the influence of 1-butyl-4(4'-allyloxyphenyl)-imidazole-hydrochloride on RNA synthesis in mengovirus infected FL cells]. PMID- 4330138 TI - Studies on virus-induced interferons produced by the human amniotic membrane and white blood cells. PMID- 4330139 TI - [Antiviral activity of imidazole derivatives. IV. Sensitivity of different viruses]. PMID- 4330141 TI - 25-Hydroxycholecalciferol: specific binding by rachitic tissue extracts. PMID- 4330140 TI - The action of tellurite, a reagent for thiol groups, on mitochondria oxidative processes. PMID- 4330142 TI - The subunit structure of beef heart cytochrome oxidase. PMID- 4330143 TI - EPR studies of the cytochrome b-c 1 segment of the mitochondrial electron transfer system. PMID- 4330144 TI - Isolation of plasma membrane from cardiac muscle. PMID- 4330145 TI - Transient pH changes during D-lactate oxidation by membrane vesicles. PMID- 4330146 TI - Coding properties of tRNA glu of mammalian origin: comparison between rat liver and minimal deviation hepatoma 5123C tRNA's glu . PMID- 4330147 TI - Regulation of myocardial cyclic AMP by isoproterenol, glucagon and acetylcholine. PMID- 4330148 TI - Ribosomal ribonucleic acid synthesis in Bacillus subtilis. AB - The mode of biosynthesis of the 16S and 23S ribosomal ribonucleic acids (rRNA) was studied in Bacillus subtilis 168thy(-). Three criteria were used to define the characteristics of the rRNA species: (i) the time required at 37 degrees C to synthesize 16S and 23S rRNA chains de novo in growing cultures; (ii) the degree of reactivity of the 3'-terminal groups of the rRNA molecules with periodate and [carbonyl-(14)C]isonicotinic acid hydrazide; and (iii) the reactivity of the 5' terminal regions of the rRNA molecules with the bacterial exonuclease purified by Riley (1969). The 16S and 23S chains of B. subtilis were synthesized at rates of 22+/-2 and 21+/-2 nucleotides added/s. The periodate-[(14)C]isonicotinic acid hydrazide and the exonuclease techniques for estimating apparent chain lengths of RNA indicated that the chain length of the 23S rRNA was 1.8 times that of the 16S fraction. The apparent chain lengths of each rRNA species were: 16S rRNA, 1650+/ 50 nucleotide residues; 23S rRNA, 3050+/-90 nucleotide residues. It appears that, the 16S and 23S rRNA molecules in B. subtilis are synthesized in the expected manner, by simple polymerization of the final products on independent cistrons. PMID- 4330149 TI - Accumulation of untranslated lactose-specific messenger ribonucleic acid during catabolite repression in Escherichia coli. AB - When Escherichia coli K-12 Hfr.H was induced to synthesize beta-galactosidase in the presence of glucose, an untranslated lactose-specific mRNA (lac-mRNA), protected from decay, was found to accumulate progressively within the cells. The lac-mRNA accumulation was unaffected by the carbon source on which the cells had been grown before the induction. The amount of the lac-mRNA available for translation was affected by catabolite repression and 3':5'-cyclic AMP, but it remained unclear whether this was a direct effect on the formation of the lac mRNA or a consequence of the effect on its translation. PMID- 4330150 TI - Biochemical and biophysical studies on cytochrome aa 3 . I. Steady-state kinetics of cytochrome aa 3 . PMID- 4330151 TI - Biochemical and biophysical studies on cytochrome aa 3 . II. Conformations of oxidized cytochrome aa 3 . PMID- 4330152 TI - Biochemical and biophysical studies on cytochrome aa 3 . 3. The EPR spectrum of NO-ferrocytochrome a 3 . PMID- 4330153 TI - Electron paramagnetic resonance and light absorption studies on c-type cytochromes of the anaerobic sulfate reducer Desulfovibrio. PMID- 4330154 TI - Evidence for the involvement of non-heme iron in the active site of hydrogenase from Desulfovibrio vulgaris. PMID- 4330155 TI - Rapid microfluorimetry of enzyme reactions in single living cells. PMID- 4330156 TI - Metachromatic effects and binding of organic cations to energized submitochondrial particles. PMID- 4330157 TI - [The action of ST 155 (2,2,6-dichlorophenylamino-2-imidazoline hydrochloride) on the hypertensive crisis induced in the rat by administration of angiotensin II]. PMID- 4330158 TI - Subacute sclerosing leucoencephalitis with an unusual pattern of cortical gangliosides. Chemical and electron microscopical study of a brain biopsy. PMID- 4330159 TI - Chemotherapy in childhood malignancies. PMID- 4330160 TI - Tumors of the genitourinary tract. Wilms' tumor. PMID- 4330161 TI - Liver tumors in children. PMID- 4330162 TI - Characterization of a soluble nuclear ribonucleoprotein antigen reactive with SLE sera. PMID- 4330163 TI - Inhibition of lymphocyte stimulation by cyclic and non-cyclic nucleotides. PMID- 4330164 TI - The role of lipid spin labels in membrane biophysics. PMID- 4330165 TI - [The renin-angiotensin-aldosterone system in arterial hypertension]. PMID- 4330167 TI - Induction of mutations in an RNA tumour virus by an analogue of a DNA precursor. PMID- 4330166 TI - Glomus jugulare tumor--a radiographic-histologic correlation. PMID- 4330168 TI - Rescue of the genome of focus forming virus from rat non-productive lines by 5' bromodeoxyruidine. PMID- 4330170 TI - [Bilateral nephroblastoma]. PMID- 4330169 TI - Enzymatic basis for platelet: collagen adhesion as the primary step in haemostasis. PMID- 4330171 TI - [Lumbar myelography with Conray Meglumin 282 and Dimer-X]. PMID- 4330172 TI - Implantation of "fast" nerve into slow muscle in young chickens. PMID- 4330173 TI - Cortical responses to visual stimulation in the developing guinea pig during the prenatal and perinatal period. PMID- 4330174 TI - Epileptic focus in the forebrain of the turtle (Testudo graeca). Triggering of focal discharges with different sensory stimuli. PMID- 4330175 TI - Activity of succinate dehydrogenase and acetylcholinesterase in synaptic endings isolated from neuropil and cerebral cortex. PMID- 4330177 TI - [Barre-Masson syndrome]. PMID- 4330176 TI - Concepts of the blood platelet release reaction. PMID- 4330179 TI - The human neutrophilic myelocyte. A correlated phase and electron microscopic study. PMID- 4330178 TI - Tissue reaction to extracorporeal circulation and elective cardiac arrest. PMID- 4330180 TI - [Intraepithelial nerve endings in stratified squamous epithelium]. PMID- 4330181 TI - Ultrastructure of glycogen-membrane complexes in sensory nerve fibres of cat muscle spindles. PMID- 4330182 TI - The hagfish retina: electron microscopic study comparing receptor and epithelial cells in the Pacific hagfish, Polistotrema stouti, with those in the Atlantic hagfish, Myxine glutinosa. PMID- 4330183 TI - Innervation of mammalian endocrine glands (anterior pituitary and parathyroids). PMID- 4330184 TI - Lactate dehydrogenase isoenzymes in tumours of the nervous system. PMID- 4330185 TI - Renal function and renin in sodium-depleted dogs. PMID- 4330186 TI - Pituitary-adrenal response to various stressors in trained and untrained organisms. PMID- 4330187 TI - Cytochrome oxidase activity and reduction capacity of ascites tumours. PMID- 4330188 TI - [Effect of reduced amounts of kinin in the blood on the inflammatory process]. PMID- 4330189 TI - Experience with Wilms' tumor in childhood. PMID- 4330190 TI - The role of preoperative arteriographic identification of the blood supply of an insulinoma in preventing intraoperative hypoglycemia. PMID- 4330191 TI - Corticotrophin therapy in juvenile chronic polyarthritis (Still's disease) and effect on growth. PMID- 4330192 TI - Gentamicin in Esch. coli gastroenteritis. PMID- 4330193 TI - Hypoglycaemia in infancy and childhood. PMID- 4330194 TI - Insulin release from human fetal pancreas in vitro. PMID- 4330195 TI - Scarification, cupping and other traditional measures, with references to folk medicine in Greece and elsewhere. PMID- 4330196 TI - Mossbauer effect in Scenedesmus and spinach ferredoxins. The mechanism of electron transfer in plant-type iron-sulphur proteins. AB - 1. The Mossbauer spectra of Scenedesmus ferredoxin enriched in (57)Fe were measured and found to be identical with those of two other plant-type ferredoxins (from spinach and Euglena) that had been previously measured. Better resolved Mossbauer spectra of spinach ferredoxin are also reported from protein enriched in (57)Fe. All these iron-sulphur proteins are known to contain two iron atoms in a molecule that takes up one electron on reduction. 2. The Mossbauer spectra at 195 degrees K have electric hyperfine structure only and show that on reduction the electron goes to one of the iron atoms, the other appearing to remain unchanged. 3. In the oxidized state, both iron atoms are in a similar chemical state, which appears from the chemical shift and quadrupole splitting to be high spin Fe(3+), but they are in slightly different environments. In the reduced state the iron atoms are different and the molecule appears to contain one high spin Fe(2+) and one high-spin Fe(3+) atom. 4. At lower temperatures (77 and 4.2 degrees K) the spectra of both iron atoms in the reduced proteins show magnetic hyperfine structure which suggests that the iron in the oxidized state also has unpaired electrons. This provides experimental evidence for earlier suggestions that in the oxidized state there is antiferromagnetic exchange coupling, which would result in a low value for the magnetic susceptibility. 5. In a small magnetic field the spectrum of the reduced ferredoxin shows a Zeeman splitting with hyperfine field (H(n)) of 180kG at the nuclei. On application of a strong magnetic field H the spectrum splits into two spectra with effective fields H(n)+/-H, thus confirming the presence of the two antiferromagnetically coupled iron atoms. 6. These results are in agreement with the model proposed by Gibson, Hall, Thornley & Whatley (1966); in the oxidized state there are two Fe(3+) atoms (high spin) antiferromagnetically coupled and on reduction of the ferredoxin by one electron one of the ferric atoms becomes Fe(2+) (high spin). PMID- 4330197 TI - Dihydroxyacetone phosphate. Its structure and reactivity with -glycerophosphate dehydrogenase, aldolase and triose phosphate isomerase and some possible metabolic implications. AB - 1. Dihydroxyacetone phosphate exists in neutral aqueous solution at 20 degrees C as a mixture of keto, gem-diol and enolic forms in the ratio 55:44:1. 2. The three forms are freely interconvertible and rate constants for these reactions have been determined. 3. Keto-dihydroxyacetone phosphate is the primary reactive species in the reactions catalysed by alpha-glycerophosphate dehydrogenase, aldolase and triose phosphate isomerase. 4. The proportion of keto form to gem diol forms of dihydroxyacetone phosphate is temperature-dependent. At 37 degrees C, 83% is keto-dihydroxyacetone phosphate. 5. The enzymological and metabolic consequences of these results are discussed. PMID- 4330198 TI - Protein phospholinase reactions in mammalian testis. Stimulatory effects of adenosine 3':5'-cyclic monophosphate on the phosphorylation of basic proteins. AB - The soluble fraction of rat testis homogenates is rich in enzymes catalysing the phosphorylation by ATP of many different proteins. The phosphorylation of certain histones, and also of a homogeneous basic protein from guinea-pig seminal-vesicle secretion, is markedly enhanced by 3':5'-cyclic AMP. Various factors affecting these reactions as catalysed by partially purified testicular enzyme preparations are described, and their possible physiological significance is discussed. PMID- 4330199 TI - Thymidine kinase of rat liver. Activation by phospholipase C and subcellular distribution in the liver. AB - 1. The thymidine kinase activity of rat liver is greatly enhanced on addition of phospholipase C to the assay mixture. 2. Most of the thymidine kinase activity of the liver is recovered in the mitochondrial and in the impure ;nuclear' fractions. No activity was detected in purified nuclei prepared in high-density sucrose. 3. A substantial thymidine kinase activity could be detected, with the aid of phospholipase C, in all rat tissues examined. PMID- 4330200 TI - Biochemical effects of kidney of exposure to high concentrations of dimethyl sulphoxide. PMID- 4330201 TI - Intracellular distribution of inorganic and organic mercury in rat liver after exposure to methylmercury salts. PMID- 4330202 TI - Distribution of acetylcholinesterase and butyrylcholinesterase in the myenteric plexus and longitudinal muscle of the guinea-pig intestine. PMID- 4330204 TI - Reduced lipolytic response in vitro to catecholamines, ACTH and cyclic adenosine monophosphate in brown fat of cold-acclimatized rats. PMID- 4330203 TI - Effects in vitro and in vivo of methylenedioxyphenyl compounds on oxidative phosphorylation in rat liver mitochondria. PMID- 4330205 TI - Effect of phenobarbital treatment on lysosomal enzyme activity in rat liver. PMID- 4330206 TI - Some species differences in the rates of reaction of diaphragm particulate acetylcholinesterases with tetraethyl pyrophosphate and pralidoxime. PMID- 4330207 TI - Rare primary renal sarcoma. PMID- 4330208 TI - Colonic tumours following uretero-sigmoidostomy. PMID- 4330209 TI - Supraspinal control of the presynaptic effects of forepaw and hindpaw skin stimulation in the cat under chloralose anaesthesia. PMID- 4330210 TI - Stretch-evoked excitatory postsynaptic potentials in motoneurons. PMID- 4330211 TI - Triggering of RNA synthesis by acetylcholine stimulation of the postsynaptic membrane in a mammalian sympathetic ganglion. PMID- 4330212 TI - Antidromic and synaptic activation of the facial nucleus of cat. PMID- 4330213 TI - The action of some cholinergic blockers on carotid body chemoreceptors in vivo. PMID- 4330214 TI - Antagonism between bicuculline and GABA in the cat brain. PMID- 4330215 TI - The effect of bicuculline on the gamma-aminobutyric acid (GABA) receptors of neurons of Periplaneta americana and Helix aspersa. PMID- 4330216 TI - Inhibition of Purkinje cells in the frog cerebellum. II. Evidence for GABA as the inhibitory transmitter. PMID- 4330217 TI - Metastatic adrenal cortical carcinoma: biochemical changes accompanying clinical regression during therapy with o,p'-DDD. PMID- 4330218 TI - Rapid fluorometric assay of estrogen conjugates in pregnancy urine. PMID- 4330219 TI - Meningioma of the parotid gland: an insight into the pathogenesis of extracranial meningiomas. PMID- 4330220 TI - The effects of oronasal administration of two strains of murine sarcoma virus in mice. PMID- 4330221 TI - Study of the invivo fixation of antibodies on tumors provoked in hamsters by injection of SV40-transformed cells (TSV 5 Cl 2 ). PMID- 4330222 TI - Rat serum lipoproteins during carcinogenesis of the liver in the preneoplastic and the neoplastic state. PMID- 4330223 TI - Glucose-6-phosphatase activity in rat liver parenchyma during azo-dye carcinogenesis. PMID- 4330224 TI - Elongation of mitochondrial fatty acids during brain development. PMID- 4330226 TI - Myasthenia gravis. PMID- 4330225 TI - Actions of dibutyryl cyclic adenosine monophosphate, papaverine and isoprenaline on the intestinal smooth muscle. PMID- 4330227 TI - [The Nobel Prize in physiology or medicine 1971. Cyclic AMP in adipose tissue]. PMID- 4330228 TI - The etiology of endemic cretinism. PMID- 4330229 TI - Some chemical and physical properties of a bacterial reaction center particle and its primary photochemical reactants. PMID- 4330231 TI - [Hospital infections due to Herpesvirus varicellae in patients with rheumatoid arthritis. Disturbances of cell-mediated immunity as a contributing factor]. PMID- 4330230 TI - Use of low-voltage electrotherapy and electromyography in physical therapy. PMID- 4330232 TI - Studies on the mechanism of protodyne-induced protection against microbial infections. PMID- 4330233 TI - Further studies on the mode of transmission of herpes-like virus in guinea pigs. PMID- 4330234 TI - Spontaneous neoplasms in germfree BALB/cPi mice. PMID- 4330236 TI - The replication of poliovirus in primary kidney cell cultures of thirteen-lined ground squirrels. PMID- 4330235 TI - Studies on the role of the adrenal in renin kinetics. PMID- 4330237 TI - Identification of the Kirk "hepatitis" virus as a member of the parvovirus (picodnavirus) group. PMID- 4330239 TI - Replication of rubella, Newcastle disease, and vesicular stomatitis viruses in cultured rheumatoid synovial cells. PMID- 4330238 TI - The effect of neuromuscular blocking agents on acetylcholine release. PMID- 4330240 TI - [The detection of interferon in the saliva of children with acute herpetic stomatitis]. PMID- 4330241 TI - [Results of radiotherapy of malignant kidney neoplasms]. PMID- 4330242 TI - Fine structure and its functional properties of the endostyle of ascidians, Ciona intestinalis. A part of phylogenetic studies of the thyroid gland. PMID- 4330243 TI - Diffusion barrier to horseradish peroxidase in the vascular stria of the guinea pig. PMID- 4330244 TI - [Ultrastructure of the neurohemal organ in the nervus corporis allati II in Acheta domesticus]. PMID- 4330245 TI - Intravenous regional anaesthesia. PMID- 4330246 TI - [Incidence of cirrhosis and hepatoma in autopsy material: development during the last 20 years]. PMID- 4330247 TI - The herpes simplex virus encephalitis in mice at different environmental temperatures. PMID- 4330249 TI - [Electron paramagnetic resonance signals in the blood of patients with inflammation of the uterine adnexa]. PMID- 4330248 TI - Antibody formation in cell cultures. 2. The effect of rabbit peritoneal exudate cells on secondary in vitro IgG and IgM antibody responses to poliovirus. PMID- 4330250 TI - An automated method for determination of kinetic properties of enzymes coupled with NAD. PMID- 4330251 TI - PMR spectrometric determination of the degree of polymerization and anomeric configuration in oligosaccharides. PMID- 4330252 TI - Bioluminescent method for determining micro quantities of ammonia in a liquid scintillation spectrometer. PMID- 4330253 TI - Specific inhibition of Rous sarcoma virus by -amanitin. PMID- 4330254 TI - Characteristics of hemagglutinins of some picodnaviruses. PMID- 4330255 TI - [The immunological adjuvant effect of viruses on the production of antibodies against host cell antigens]. PMID- 4330256 TI - Studies of the heat lability of mouse anti-Sendai virus immune sera. PMID- 4330258 TI - Detection of equine infectious anemia virus in vitro by immunofluorescence. PMID- 4330257 TI - Induction of cellular DNA synthesis during lytic infection with SV 40: a function of viral genome. PMID- 4330259 TI - Removal of contaminating protein from high titre virus suspensions to be used in the production of antisera for immunofluorescence. PMID- 4330260 TI - An improved in vitro assay for cell-free Marek's disease virus. Brief report. PMID- 4330261 TI - Non-specific brain inhibitor against measles virus. PMID- 4330262 TI - Enzymatic repair of deoxyribonucleic acid. IV. Mechanism of photoproduct excision. PMID- 4330263 TI - Studies on the roles of the catalytic and allosteric sites in modulating the reactivity of tryptophan oxygenase with heme ligands. I. Cyanide derivatives. PMID- 4330264 TI - Aspartate transcarbamylases of Citrobacter freundii. PMID- 4330265 TI - Synthesis and catalytic activity of spin-labeled cobinamide coenzymes. PMID- 4330267 TI - Phenylalanine-hydroxylating system in the human fetus at different developmental ages. PMID- 4330266 TI - L-glutamine:D-fructose 6-phosphate amidotransferase in tumors and the liver of tumor-bearing animals. PMID- 4330268 TI - Dietary regulation of glycolytic enzymes. XI. Effect of inhibitors of protein synthesis on the adaptation of certain jejunal glycolytic and folate-metabolizing enzymes to diet and sex steroids. PMID- 4330269 TI - Enterochelin hydrolysis and iron metabolism in Escherichia coli. PMID- 4330270 TI - On the metabolic activation of N-hydroxy-N-2-acetylamino-fluorene. II. Simultaneous formation of 2-nitrosofluorene and N-acetoxy-N-2-acetylaminofluorene from N-hydroxy-N-2-acetylaminofluorene via a free radical intermediate. PMID- 4330271 TI - On the metabolic activation of the carcinogen N-hydroxy-N-2-acetylaminofluorene. 3. Oxidation with horseradish peroxidase to yield 2-nitrosofluorene and N-acetoxy N-2-acetylaminofluorene. PMID- 4330272 TI - Glycolysis by human spermatozoa: levels of glycolytic intermediates. PMID- 4330273 TI - [Ectopic hormonal secretions of cancerous origin]. PMID- 4330274 TI - Fluctuations in antibiotic resistances of gram-negative rods in one hospital, 1961-70, with comment on kanamycin-neomycin relationships. AB - Records of the percentages of various types of gram-negative rods resistant to six antibiotics are presented for the years 1961 to 1969 with additional notes on 1970. Gross amounts of each antibiotic used in each of the years are also depicted. Resistance-factor transference does not seem to be an important factor but levels of antibiotic usage do seem to affect the percentages of resistant strains found. In the case of kanamycin, extensive use of neomycin appears to have produced much cross-resistance. Free use of polymyxins does not seem to increase resistant percentages. PMID- 4330276 TI - Interference with immunoassays of angiotensin I and II by proteins in human plasma. PMID- 4330275 TI - Treatment of malignant brain tumors with nitrosoureas. PMID- 4330277 TI - Developmental potential of isolated Dictyostelium myxamoebae. PMID- 4330279 TI - DNA and protein metabolism after liver autotransplantation. PMID- 4330278 TI - Report of 1st International Conference on Cell Differentiation sections I and IV- Embryology and Cell Biology. PMID- 4330282 TI - The double role of water in quantitative electron spin resonance (ESR) determinations on samples of biological materials. PMID- 4330281 TI - Electron spin resonance (ESR) studies on living cells. II. Normal development of amphibians. PMID- 4330280 TI - A method for histochemical demonstration of -glycerophosphateferricyanide oxidoreductase activity. PMID- 4330283 TI - Enzymatic studies of the dental pulp in dogs. I. Phosphatases. PMID- 4330284 TI - [Endoscopic findings in essentially bronchopulmonary diseases]. PMID- 4330285 TI - [Disappointment in angiographic studies of the pancreas]. PMID- 4330286 TI - Study on dioxan separation in the radioimmunoassay of human growth hormone, human chorionic gonadotrophin, adrenocorticotrophic hormone, and insulin. AB - The dioxan precipitation for separating free from antibody-bound hormone in a radioimmunoassay has been applied to human chorionic gonadotrophin (HCG), human growth hormone (HGH), adrenocorticotrophic hormone (ACTH), and insulin and compared with the charcoal-dextran system of separation. The dioxan separation depends on protein concentration. The behaviour of damaged labelled hormone is difficult to assess. Completeness of separation has to be tested in antigen excess. The optimum conditions must be carefully studied for each hormone. PMID- 4330287 TI - The circular dichroism of synaptosomal membranes: studies of interactions with neuropharmacological agents. PMID- 4330288 TI - Stimulation of brain serotonin synthesis by dibutyryl-cyclic AMP in rats. PMID- 4330289 TI - Effect of cyanide and electrical stimulation on phosphoinositide metabolism in lobster nerves. PMID- 4330290 TI - Cerebral phospholipids in 'quaking' mice. PMID- 4330291 TI - Ganglioside inactivation of botulinum toxin. PMID- 4330292 TI - Studies on rubber base impression materials. XXIV. Discussions on the setting mechanism of polysulfide rubber as the dental impression material, chiefly viewed from the variations of viscosity and molecular weight. 4. Fillers and plasticizers. PMID- 4330293 TI - Hepatoma metastasis to bone. PMID- 4330294 TI - [Clinical studies on the relation between aldosterone and various hypertensive and renal diseases. 2. Studies on the effect of synthetic angiotensin II on aldosterone secretion rate]. PMID- 4330295 TI - On the mechanism of action of lac repressor. PMID- 4330296 TI - Replicating SV40 molecules containing closed circular template DNA strands. PMID- 4330297 TI - "Unblocking" serum activity in vitro in the polyoma system may correlate with antitumour effects of antiserum in vivo. PMID- 4330298 TI - Adrenaline increases cyclic 3'5'-AMP formation in hamster epidermis. PMID- 4330299 TI - [Apropos of a case of neonatal herpes of generalized form]. PMID- 4330300 TI - [Endocrine tumors of the ovary in children]. PMID- 4330301 TI - [Plasma protein hormones. Interpretation of their radio immunologic determination]. PMID- 4330302 TI - [Analysis of the results of cerebral angiography in cerebral tumors]. PMID- 4330303 TI - Norepinephrine stinulated increase of cyclic AMP levels in developing mouse brain cell cultures. AB - Norepinephrine causes a four- to sixfold increase in the intracellular level of cyclic AMP (adenosine 3', 5'-monophosphate) reaggregated brain cell cultures derived from embryonic mouse brain. The cyclic AMP level of adult brain is increased by norepinephrine; however, embryonic mouse brain does not show a cyclic AMP response. The aggregate cultures thus demonstrate an event of differentiation very similar to that seen in vivo. PMID- 4330304 TI - Cyclic adenosine monophosphate: function in photoreceptors. AB - Inactivation of adenylate cyclase in outer segments of retinal photoreceptor cells is proportional to the bleaching of rhodopsin. Membranes of the outer segments also contain a particulate, light-insensitive phosphodiesterase of high specific activity. In electrophysiological experiments, application of cyclic adenosine monophosphate along with a methylxanthine mimics the effects of illumination on the photoreceptor cell of the compound eye of Limulus. PMID- 4330305 TI - [Clinical and x-ray diagnosis of phyllode breast neoplasms]. PMID- 4330306 TI - [Sjogren's syndrome in chronic cytomegaly]. PMID- 4330307 TI - [Immunological activity of renin and angiotensin]. PMID- 4330308 TI - [Quantitative studies of a diffusion problem with enzymatically reduced pyridine nucleotide: a contribution to the histochemical localization of pyridine nucleotide-dependent dehydrogenases]. PMID- 4330309 TI - Histochemical demonstration of nucleoside triphosphate hydrolysis in the mouse dentition. PMID- 4330310 TI - Aldosteronotropic effect of the pituitary incubation medium in the rat. PMID- 4330311 TI - Optic nerve damage diagnosis based on visual-olfactory interaction and the parabiosis. PMID- 4330312 TI - Antibiotic susceptibilities of Serratia marcescens and Enterobacter liquefaciens. AB - Production of 5'-nucleotides by Serratia marcescens and Enterobacter liquefaciens correlates with deoxyribonuclease production, indicating the close relationship between these two organisms. To determine further relationships, susceptibilities of 279 strains of the tribe Klebsielleae were determined by the high-potency disc method, agar-dilution method, or both, by using 14 antibiotics. Ninety-seven per cent of S. marcescens (201 of 207 strains) and 100% of E. liquefaciens (17 strains) had minimum inhibitory concentration (MIC) of 100 mug/ml or greater with colistin and polymyxin B. With these two antibiotics, 93% of other Enterobacter species (28 strains) had MIC values of less than 1.6 mug/ml, and 100% of Klebsiella (27 strains) had MIC values less than 1.6 mug/ml. Consistent patterns were not noted with the other antibiotics tested, but the results with colistin and polymyxin B provide additional evidence of the close relationship of S. marcescens and E. liquefaciens. PMID- 4330313 TI - Thermal resistance of certain oncogenic viruses suspended in milk and milk products. AB - Thermal destruction rate curves were determined for adenovirus 12, reovirus 1, and herpes simplex virus in sterile milk, raw milk, raw chocolate milk, and raw ice cream mix. At 40 to 60 C, the curves were asymptotic to the base line. At 65 C, which is near the pasteurization standard, the curves approached a first-order reaction. Thermal resistance studies, by means of in vivo assays, of Moloney and Rauscher leukemia viruses and Moloney and Rous sarcoma viruses indicated that Rous sarcoma was the most resistant. A comparison of the 12D processes of Rous sarcoma virus, reovirus 1, adenovirus 12, and herpes simplex virus in ice cream mix (the most protective of the suspending menstrua studied) with the U.S. Public Health Service pasteurization standard indicated an adequate safety factor in current pasteurization practices. PMID- 4330314 TI - In vitro chemotherapeutic combinations against isoniazid-resistant Mycobacterium tuberculosis and Mycobacterium fortuitum. AB - It is an acceptable medical practice to use second-line antimycobacterial drugs in combination with isoniazid in treatment of isoniazid-resistant tuberculosis. Recent investigations have demonstrated the importance of determining chemotherapeutic interaction in instances of multiple antibiotic use. We studied the inhibitory effect of combinations of isoniazid with ethambutol, rifampin, ethionamide, cycloserine, viomycin, and kanamycin against three isoniazid resistant strains of Mycobacterium tuberculosis and three strains of M. fortuitum. The isobologram technique with drug concentrations of 0.4 to 100 mug/ml was used. With the exception of single instances in which kanamycin plus isoniazid (M. tuberculosis strain 9999) and ethionamide plus isoniazid (M. fortuitum strain 2080) seemed to have a synergistic effect, neither synergy nor antagonism was noted for any of the combinations. These studies show that the combined use of isoniazid and a second line antimycobacterial agent results in vitro in indifferent inhibitory activity. PMID- 4330315 TI - Dose responsiveness and variation among inbred strains of mice in production of interferon after treatment with poly (I)-poly (C) (poly-D-lysine) complexes. AB - Poly-d-lysine forms a stochiometric complex with poly(I) . poly(C) which has a higher T(m) (83 C in 0.15 m NaCl) than the uncomplexed double-stranded polyribo nucleotide (63 C). The complex was superior to poly(I) . poly(C) alone as an interferon inducer in vivo. Significant serum interferon titers were attained in Swiss mice during a 24-hr period after intraperitoneal injection of 10 to 300 mug of poly(I) . poly(C) [1.0 poly-d-lysine] complex, at concentrations of 100 to 1,000 mug/ml. The serum interferon responses (average and maximum titers) of a series of inbred strains of mice to a single intraperitoneal injection of 100 mug of complex decreased in the order: Swiss > DBA/2 > C3H > BALB/c > CF-1 > AKR, C57Bl/6, NZB > SJL > NZW and varied by a factor of approximately 100 from the most to the least responsive. PMID- 4330316 TI - Characterization of a heat-shock process for reduction of the nucleic acid content of Candida utilis. AB - A process for reducing the nucleic acid content of Candida utilis NRRL Y900 has been developed. The optimal process consists of heating the cells suspended in spent medium initially at pH 4.0 for various times at three different temperatures. Initially a heat-shock at 68 C for 1 to 3 sec is performed followed by incubation for 1 hr at 45 to 50 C and for a 2nd hr at 52 to 55 C. The distribution of degradation products has been characterized. Initially 90% of the nucleic acids were in a polymerized form (extractable by hot perchloric acid). After 30 min, much of this material was hydrolyzed but remained within the cell (extractable by cold perchloric acid). After 2 hr, most of the hydrolysis products leaked into the surrounding medium with only a small amount of low molecular-weight material remaining within the membrane. Predominantly 3' mononucleotides accumulated within the cell and eventually leaked from the cell. PMID- 4330317 TI - Effect of administered interferon on rabies in rabbits. AB - This study describes the effect of interferon on the survival of rabbits infected with a street strain of rabies virus. Interferon was prepared by collecting serum from rabbits injected with Newcastle disease virus and was characterized by biological and physicochemical methods. Rabbit serum interferon mixed and incubated with a suspension of rabies virus did not neutralize its infectivity. Rabbits were inoculated into the hind leg muscle with approximately 80 LD(50) of virus. Interferon was administered intravenously or intramuscularly, or by both methods, in the same or opposite leg as virus. Mortality due to rabies was significantly reduced by the concurrent administration of 8 x 10(5) units of interferon divided between the site of virus inoculation and intravenously. There was less protection if 3 hr elapsed between the inoculation of virus and interferon. Treatment given 24 hr after infection did not prevent death but prolonged the incubation period. PMID- 4330318 TI - Efficacy and safety of topical lysostaphin treatment of persistent nasal carriage of Staphylococcus aureus. AB - The efficacy of lysostaphin nasal spray and Neosporin ointment (Burroughs Wellcome & Co.) in altering nasal carriage of Staphylococcus aureus was studied with persistent carriers in an institution for mentally retarded children and adults. Treatment for 5 days with either agent significantly reduced carriage rates. This effect persisted through the 5th day after therapy with lysostaphin but not with Neosporin. By the 11th day after therapy, carriage rates in the treatment and control groups were not significantly different. Except for a single immediate wheal and flair skin test reaction, no other evidence of adverse reactions to topical lysostaphin was detected. No consistent changes in hemagglutination-inhibition titers to lysostaphin were observed after therapy. Lysostaphin appears to be slightly more effective than conventional topical antimicrobial therapy in reducing nasal carriage of staphylococci in this rigorously defined population of persistent carriers. PMID- 4330319 TI - Transport media for herpes simplex virus types 1 and 2. AB - An evaluation was made of the recovery rate of herpes simplex virus (HSV) type 1 or 2 from 197 clinical specimens obtained in two or three charcoal transport media: Leibovitz viral transport medium, a modified Leibovitz-Emory medium (LEM), in which agarose was used instead of agar, and Amies bacterial transport medium. The specimens were stored and shipped for 1 to 19 days in these media at ambient temperature or in Hanks buffered-salt solution in dry ice. The results indicate that the LEM was most effective, particularly in the recovery of HSV type 2 from clinical specimens held at ambient temperature. In vitro and in vivo studies in genitally infected mice corroborated the observations obtained with human clinical specimens. The availability of transport media which can be used for shipment at ambient temperature offers clinicians easier accessibility to laboratory confirmation and antigenic typing of HSV from suspect herpetic infections. PMID- 4330320 TI - Rapid identification and typing of herpes simplex virus types 1 and 2 by a direct immunofluorescence technique. AB - An immunofluorescence (FA) technique has been developed which can identify herpes simplex virus (HSV) in clinical specimens and also type the virus directly as type 1 or type 2. This test, first applied to cervicovaginal specimens obtained from 80 mice genitally inoculated with HSV, indicated a sensitivity approaching 80% in comparison to standard viral isolation methods. A similar sensitivity was found when the test was applied to 185 clinical specimens with adequate cells for staining, which were obtained from a variety of sites of patients with suspect herpetic infection. In only 1 of 6 specimens positive by both FA and culture methods was the HSV type wrongly identified by the FA technique. There were also six specimens which were negative by culture methods but positive by the FA test, indicating a specificity of 91%. It is likely that these are not instances of false-positive tests but of other factors which may have resulted in negative viral isolations by culture methods. As more specific reagents become available, it is anticipated that the FA technique will have wider usage in diagnostic laboratories for the identification and typing of HSV types 1 and 2. PMID- 4330321 TI - [Pharmacologic study of 4 fractions of Soja lipexidase]. PMID- 4330322 TI - The effects of selected phenothiazines on the sleep of cats. PMID- 4330323 TI - Screening for adrenocortical insufficiency with cosyntropin (synthetic ACTH). PMID- 4330324 TI - [Methods and results of quantitative mineral salt determination on the skeleton of children]. PMID- 4330325 TI - Electron paramagnetic resonance studies of manganese (II) coordination in the phosphoglucomutase system. PMID- 4330326 TI - Electron paramagnetic resonance study of the interaction of yeast enolase with activating metal ions. PMID- 4330327 TI - Stereospecific synthesis of D-1-fluorodeoxyglycerol 3-phosphate and its effects on glycerol 3-phosphate dehydrogenase. PMID- 4330328 TI - Primary sequence of tRNA val from Escherichia coli B. I. Oligonucleotide sequences of digests of Escherichia coli tRNA val with RNase T and pancreatic RNase. PMID- 4330329 TI - Stimulation of cytochrome c synthesis in the developing Polyphemus moth by aminolevulinic acid. PMID- 4330330 TI - Chromatographic studies of the lipid components of Vibrio fetus. PMID- 4330331 TI - Spectrum of fatty acids synthesized in situ and metabolic heterogeneity of free fatty acids and glycerides within isolated rat adipocytes. PMID- 4330332 TI - The regulation of sn-glycerol-3-phosphate acylation by cytidine nucleotides in rat brain cerebral hemispheres. PMID- 4330333 TI - Biosynthesis of cardiolipin in the membranes of Micrococcus lysodeikticus. PMID- 4330334 TI - Stimulation of adrenal cholesterol side chain cleavage activity by theophylline. PMID- 4330335 TI - Ethyl and methyl oleate: a pitfall in the assay of adipose tissue glycerol ester hydrolase activity. PMID- 4330336 TI - [Cortico-adrenal disturbances in chronic respiratory insufficiency patients]. PMID- 4330337 TI - An enzymatic fluorimetric micromethod for the determination of acetoacetate, hydroxybutyrate, pyruvate and lactate. PMID- 4330338 TI - A simple and rapid thin-layer chromatographic method for the assay of intestinal disaccharidases. PMID- 4330340 TI - Plasma "cortisol" levels in pellagrins. PMID- 4330339 TI - A NADH-dependent transketolase assay in erythrocyte hemolysates. PMID- 4330342 TI - Status asthmaticus in children. PMID- 4330341 TI - Role of platelets in blood-surface interactions. PMID- 4330344 TI - "Intermediate" antigens induced by herpes simplex virus in brain tissue of white mice. PMID- 4330345 TI - Interactions of avian sarcoma virus with rat embryo cells in cell culture. PMID- 4330346 TI - Evidence for large strands of ribonucleic acid induced by a bovine enterovirus. PMID- 4330347 TI - Influence of type and concentration of sera in vitro on susceptibility of genetically resistant cells to mouse hepatitis virus. PMID- 4330348 TI - Fatty acid composition of individual phospholipids of influenza virus. PMID- 4330349 TI - Resistance to virus infection during the hyporeactive state of interferon induction. PMID- 4330351 TI - Islet cell tumors and hyperinsulinism: a case report. PMID- 4330350 TI - Genetic characteristics of clones from individual cells multiply-infected with different strains of foot-and-mouth disease virus. PMID- 4330352 TI - Hybridization between SV40 DNA and cellular DNA's. PMID- 4330353 TI - The sizes of the two main histochemical fibre types in five limb muscles in man. An autopsy study. PMID- 4330354 TI - Effect of germine acetates on neuromuscular transmission. PMID- 4330355 TI - Differentiation of brain lesions by sequential gamma camera studies. PMID- 4330356 TI - Peripheral neuropathy and myeloma. PMID- 4330357 TI - Granular sheath cell lesions: report of cases. PMID- 4330358 TI - Management of blunt renal trauma. PMID- 4330359 TI - The incidence of benign renal nodules (a clinicopathologic study). PMID- 4330360 TI - A retrospective analysis of 70 cases of cutaneous ureterostomy. PMID- 4330361 TI - Survival after right nephrectomy, excision of infrahepatic vena cava and ligation of left renal vein: a case report. PMID- 4330363 TI - Effects of Cytembena in the treatment of malignant musculoskeletal tumours. PMID- 4330364 TI - [Clinical significance of the immunosuppressive effect of cyclophosphamide]. PMID- 4330365 TI - Brain norepinephrine and serotonin levels following REM sleep deprivation in the rat. PMID- 4330362 TI - System of double infection between vaccinia virus and mengovirus. AB - When L cells are simultaneously infected with vaccinia virus and mengovirus, double interference in the replication of both viruses is observed. Superinfection of vaccinia virus-infected cells by mengovirus during the first 5 hr of infection reduces vaccinia virus yields to between 1 and 3% of controls. The yields of mengovirus are reduced to between 1 and 16% of controls, depending upon the time of superinfection. The replication of vaccinia deoxyribonucleic acid is not inhibited by mengovirus; it is only delayed. On the other hand, vaccinia multiplication severely hinders the replication of mengovirus ribonucleic acid. The double-infected system, at early times, synthesizes proteins that resemble those synthesized in the vaccinia virus-infected cells. Later in infection, however, the pattern is switched to proteins synthesized by mengovirus-infected cells. Possible mechanisms for this double interference in multiplication are discussed. PMID- 4330366 TI - Cocarcinogenesis: the interaction of chemical and physical agents. PMID- 4330367 TI - Murine leukemia virus: high-frequency activation in vitro by 5-iododeoxyuridine and 5-bromodeoxyuridine. AB - Cells of embryos of the high leukemic mouse strain AKR can be grown in culture as virus-negative cell lines. However, these lines and clonal sublines uniformly have the capacity to initiate synthesis of murine leukemia virus. Exposure of the cells to 5-iododeoxyuridine or 5-bromodeoxyuridine induced synthesis of virus in as high as 0.1 to 0.5 percent of the cells; many of the cells were producing virus as soon as 3 days after initiation of treatment. Induction of virus by these drugs is several orders of magnitude greater than that obtained with any other treatment tested. These studies indicate that the full genome of murine leukemia virus is present in an unexpressed form in all AKR cells and provide a potentially powerful technique for activating leukemia virus genomes in other cell systems. PMID- 4330368 TI - Studies of the protein subunit of pH-inactivated Mengo virus variants. II. Physicochemical properties. PMID- 4330369 TI - The group-specific antigen and other structural proteins of hamster and mouse C type viruses. PMID- 4330370 TI - Structure and synthesis of a lipid-containing bacteriophage. V. Phospholipids of the host BAL-31 and of the bacteriophage PM2. PMID- 4330371 TI - [Cytophotometric studies of cell nuclei from experimentally induced neoplasms]. PMID- 4330372 TI - [Ewing sarcoma cells in tissue culture: cytology and verification of virus particles]. PMID- 4330373 TI - [Histogenesis and cytogenesis of cholangiocellular tumors in nitrosomorpholine intoxicated rats. A contribution to the morphogenesis of polycystic disease of the liver]. PMID- 4330374 TI - [Duplication of aortic wall cells in arterial hypertension]. PMID- 4330375 TI - Cataracts in the Smith-Lemli-Opitz syndrome. PMID- 4330376 TI - Monamine oxidase inhibitors and brain monamines in clinical conditions. PMID- 4330377 TI - Temperature and the regulation of enzyme activity in poikilotherms. Regulatory properties of fructose diphosphatase from muscle of the Alaskan king-crab. AB - 1. The properties of fructose diphosphatase from skeletal muscle of the Alaskan king-crab (Paralithodes camtschatica) were examined over the physiological temperature range of the animal. 2. King-crab muscle fructose diphosphatase is first activated by Na(+) and NH(4) (+) and is then partially inhibited by these cations at concentrations higher than 10mm at 0 degrees , 8 degrees and 15 degrees C. Enzyme activity is stimulated by K(+) at 0 degrees C, but is curtailed at 8 degrees C and 15 degrees C, an effect that could render rate independent of temperature. 3. Affinity for substrate increases with decreasing temperature; below the temperature of acclimatization, K(m) for fructose 1,6-diphosphate increases, resulting in a complex U-shaped temperature-K(m) curve. 4. King-crab muscle fructose diphosphatase is inhibited by low concentrations of AMP. As with enzymes of other poikilotherms, inhibition by AMP is sensitive to temperature; the enzyme is least sensitive to inhibition by AMP near the temperature of acclimatization. 5. The affinity of fructose diphosphatase for fructose 1,6 diphosphate is enhanced by phosphoenolpyruvate, and this activation is temperature-sensitive; 0.5mm-phosphoenolpyruvate causes a sevenfold decrease in K(m) for fructose 1,6-diphosphate at 15 degrees C but a 25-fold decrease at 0 degrees C. 6. Phosphoenolpyruvate appears to decrease the affinity of king-crab muscle fructose diphosphatase for AMP at low temperature, whereas at the higher temperature it appears to enhance inhibition by AMP. Phosphoenolpyruvate was not observed to cause a reversal of inhibition of fructose diphosphatase activity by AMP. The identification of phosphoenolpyruvate as an activator of a rate-limiting step in gluconeogenesis permits the suggestion of a coupling of the controlling mechanisms of several steps in the glycolytic and gluconeogenic chains. 7. These findings suggest mechanisms for the maintenance and regulation of control of fructose diphosphatase activity in king-crab skeletal muscle at low temperature and under conditions that favour concomitant activity of phosphofructokinase. PMID- 4330378 TI - Properties of yeast grown anaerobically in media limiting in potassium. AB - 1. Saccharomyces cerevisiae was grown anaerobically in media with different concentrations of K(+) down to less than 1mm. Below 3.2mm the K(+) concentration limited the growth rate and yield. 2. Yeast extract was essential for maximum growth. The yield of cells when the medium contained 0.83mm-K(+) was only 30% of the yield with 90mm-K(+). 3. At the end of anaerobic growth the cells grown in 0.83mm-K(+) had a higher concentration of oxidative enzymes than cells grown in 90mm-K(+). 4. The cells grown anaerobically in 0.83mm-K(+) could adapt to aerobic conditions if K(+) was present in the adaptation medium, but not otherwise. 5. The enzyme pattern of the yeast grown aerobically in 0.83mm-K(+) was very similar to the anaerobically grown cells and did not change markedly after the glucose was consumed. PMID- 4330379 TI - A simple and sensitive saturation assay method for the measurement of adenosine 3':5'-cyclic monophosphate. PMID- 4330380 TI - The nature of the cytoplasmic-3-hydroxybutyrate dehydrogenase from sheep kidney. PMID- 4330381 TI - New directions in dream psychology research. PMID- 4330382 TI - Neurology and sleep research. PMID- 4330383 TI - Neurophysiological findings concerning sleep and psychoanalytic theory. PMID- 4330384 TI - Implications of recent dream research. PMID- 4330385 TI - Contributions to psychiatry of recent studies on sleep. PMID- 4330386 TI - Chemodectoma of the aortic body. PMID- 4330387 TI - The dilemma of the asymptomatic pulmonary nodule in the young and not-so-young adult. Clinical conference in pulmonary disease from Northwestern University- McGaw Medical Center, Chicago. PMID- 4330388 TI - Studies of the glycopeptides and of the swelling pattern of the calf (Bos taurus) cornea modified by periodate oxidation. PMID- 4330389 TI - Activities of some enzymes involved in lipogenesis, gluconeogenesis, glycolysis and glycogen metabolism in chicks (Gallus domesticus) from day of hatch to adulthood. PMID- 4330390 TI - The lipid metabolism of blood and culture forms of Trypanosoma lewisi and Trypanosoma rhodesiense. PMID- 4330391 TI - [Virostatic treatment of eruptive warts. Preliminary report]. PMID- 4330392 TI - [Growth disorders in childhood]. PMID- 4330393 TI - [Effect of after-therapy in spas on serum lipids of patients after acute coronary attack]. PMID- 4330394 TI - Effect of alternate-day steroid administration on adrenal function in allergic children. PMID- 4330395 TI - Neurohypophysial hormone and the release of luteinizing hormone from bovine pituitary slices in vitro. PMID- 4330396 TI - Effects on flavor of fortifying milk with iron and absorption of the iron from intestinal tract of rats. PMID- 4330398 TI - Are there unidentified factors in the control of aldosterone secretion. PMID- 4330397 TI - [Iatrogenic hypothyroidism]. PMID- 4330399 TI - Renin-angiotensin system in anephric patients. PMID- 4330400 TI - Aldosterone secretion in anephric patients. PMID- 4330402 TI - [Characteristics of hemispheric astrocytic tumors at an early age]. PMID- 4330401 TI - Amphetamine abuse: a "speed" trap. PMID- 4330403 TI - The immune response of channel catfish. I. Basic responsiveness to soluble and viral antigens. PMID- 4330404 TI - [Neurogenic lung-tumors]. PMID- 4330405 TI - [Medicamentous muscle relaxation and hypocapnic muscle release]. PMID- 4330406 TI - Sensory innervation of the tentacles of the polychaete, Sabella pavonina. PMID- 4330407 TI - [Sense organs of Symphyla (Myriapoda). II. Ultrastructure of the temporal organ of Scutigerella immaculata Newport]. PMID- 4330408 TI - Structure of the pineal organs of Anguilla anguilla L. and Lebistes reticulatus Peters (Teleostei). PMID- 4330410 TI - Ultrastructural studies on the hypothalamic neurosecretory neurones of the rat. I. The paraventricular neurones of the non-treated rat. PMID- 4330409 TI - Cytomembrane differentiation in a ciliate, Tetrahymena pyriformis. II. Bifacial cisternae and tubular formations. PMID- 4330411 TI - [Ultrastructure of the CSF contacting neurons of the central canal of the spinal cord in the carp (Cyprinus carpio)]. PMID- 4330412 TI - The rostral zone of the intermediate lobe of the mouse hypophysis, a zone of particular concentration of corticotrophic cells. A light and electron microscopic study. PMID- 4330413 TI - [Light and electron microscopic investigations on the basal plate of the human placenta at term]. PMID- 4330414 TI - Microtubules and filaments in the taste bud. PMID- 4330415 TI - Successful treatment of vagotomy of 2 patients with peptic ulcer and Stokes-Adams (vasovagal) syncope. PMID- 4330416 TI - Regression of early cholesterol-induced aortic lesions in rhesus monkeys. AB - The reversibility of early uncomplicated cholesterol-induced aortic lesions in rhesus monkeys was investigated. Three groups of Rhesus monkeys were used: the control group was fed a chow diet for 8 weeks; the progression group was fed an atherogenic diet for 8 weeks and the regression group was fed an atherogenic diet for 8 weeks and returned to the chow diet for 16 weeks. The lesions produced in the progression animals characteristically contained many lipid-laden monocytes immediately beneath the endothelium, abundant lipid droplets in intimal smooth muscle cells and moderate amounts of lipid in the extracellular spaces. Lesions in regression animals contained few lipid-laden monocytes, less lipid in smooth muscle cells and larger and more numerous lipid particles in the extracellular spaces. The results indicate that aortic lesions can be produced predictably after 8 weeks of feeding a high-cholesterol diet and that qualitative changes in the lesions occur 16 weeks after withdrawal from the diet. PMID- 4330417 TI - Fatal adenovirus pneumonia in infants. Correlation of histologic and electron microscopic observations. AB - Many structures morphologically identical with adenovirions were found in large numbers in typically altered respiratory epithelial cells in 10-year-old sections stained with hematoxylin and eosin of 2 cases of a histologically unique type of fatal pneumonia in infancy. These observations confirm, beyond reasonable doubt, an etiologic role of adenoviruses in the initiation and development of this type of pneumonia. The technic used, which was a modification of one previously described, is given in detail, since such methods may be useful in solving other etiologic problems. PMID- 4330418 TI - [Pulmonary miliary shadows due to lipiodol following lymphography]. PMID- 4330419 TI - Pemphigus. A 20-year survey of experience with 70 cases. PMID- 4330421 TI - Cushing's syndrome cured resection of appendiceal carcinoid. PMID- 4330420 TI - Infections caused by achloric algae (protothecosis). PMID- 4330422 TI - The occurrence of an adenovirus and a herpesvirus in a chicken with Marek's disease. PMID- 4330423 TI - Response of mammalian histidine catabolic enzymes to dietary and hormonal treatments. PMID- 4330424 TI - The function of menaquinone (vitamin K 2 ) in Escherichia coli K-12. PMID- 4330425 TI - Transformation of glucosamine to glycogen and lactate by ascites tumor cells. PMID- 4330426 TI - Two different enzymes for the biosynthesis of UDP-xylose from UDP-glucuronic acid in cell suspension cultures of parsley (Petroselinum hortense). PMID- 4330427 TI - Determination of the zero-field splitting of Fe 3+ in heme proteins from the temperature dependence of the spin-lattice relaxation rate. PMID- 4330428 TI - A rapid isotopic method for assessing the biosynthesis of ether linkages in glycerolipids of complex systems. PMID- 4330429 TI - Characterization of the agarolytic system of Agarbacterium pastinator. PMID- 4330431 TI - The in vivo effect of adrenorcorticortropin on the biosynthesis of flavin nucleotides in rat liver and kidney. PMID- 4330432 TI - Effect of aniline on plasma corticosterone in rats. PMID- 4330430 TI - Regulation of enzyme activities related to the biosynthesis of flavone glycosides in cell suspension cultures of parsley (Petroselinum hortense). PMID- 4330433 TI - The regulation of beta-hydroxy-beta-methylglutaryl coenzyme A reductase in Morris hepatomas 5123C, 7800, and 9618A. PMID- 4330434 TI - Comparative oligonucleotide sequences of 28 S ribosomal RNA normal liver and Novikoff hepatoma ascites cells. PMID- 4330435 TI - Structure-activity relationships in toxicity and carcinogenicity of aflatoxins and analogs. PMID- 4330436 TI - Effect of endocrine organ ablation on the uptake and clearance of 9, 10-dimethyl 1,2-benzanthracene-9-14C by mammary parenchymal cells of the rat. PMID- 4330437 TI - Effect of rifampicin and a derivative on cells transformed by Rous sarcoma virus. PMID- 4330438 TI - DNA biosynthesis by isolated mitochondria. Stimulation by cytoplasmic factors from neoplastic and regenerating tissues. PMID- 4330439 TI - Isolation of tumor cell surface binding sites for concanavalin A and wheat germ agglutinin. PMID- 4330440 TI - Studies on mouse mammary tumor virus (MTV) and mouse leukemia virus (MuLV) by immunoelectron microscopy. PMID- 4330441 TI - A search for gene derepression in RNA of primary rat hepatomas. PMID- 4330442 TI - Alteration in the distribution of basic soluble rat liver proteins during azo dye carcinogenesis. PMID- 4330443 TI - Elongated nuclear sheet and intranuclear myelin figure of human medulloblastoma. PMID- 4330444 TI - The effect of age, fractionation, and dose on radiation carcinogenesis in various tissues of mice. PMID- 4330445 TI - Perinatal carcinogenesis by urethan. PMID- 4330446 TI - Activity and ultrastructure of mitochondria from mouse mammary gland and mammary adenocarcinoma. PMID- 4330448 TI - Lactate dehydrogenases from crustaceans and arachnids. PMID- 4330447 TI - Metabolism of hepatomas of different growth rates in situ and during ischemia. PMID- 4330449 TI - The lipid composition of the blood of marine mammals. II. Atlantic bottlenose dolphins, Tursiops truncatus and two species of seals, Halichoerus grypus and Phoca vitulina. PMID- 4330450 TI - Incorporation of 33p-orthophosphate into membrane phospholipids of Plasmodium knowlesi and host erythrocytes of Macaca mullatta. PMID- 4330451 TI - Nephropathy in sucrose-fed rats. Electron and light microscopic studies. PMID- 4330452 TI - [Distal slipped epiphysis on the metatarsus (with medial dislocation) in a young cow]. PMID- 4330453 TI - Some characteristics of an adenyl cyclase preparation from rabbit ciliary process tissue. PMID- 4330454 TI - Coincident parotid tumors. PMID- 4330457 TI - Complement-requiring neutralizing antibodies in hyperimmune sera to human cytomegaloviruses. PMID- 4330456 TI - Ocular manifestations of feline herpesvirus infection. PMID- 4330458 TI - Immunoglobulins in intact, immunized, and contaminated axenic mice: study of serum IgA. PMID- 4330455 TI - Somatic cell hybridization and problems of viral oncogenesis. PMID- 4330459 TI - Serum and secretory IgA in axenic and holoxenic mice. PMID- 4330460 TI - Regulation of homocytotropic antibody formation in the rat. VI. Inhibitory effect of thymocytes on the homocytotropic antibody response. PMID- 4330461 TI - Transplacental chemical carcinogenesis in man. PMID- 4330462 TI - Transfer RNA species in solid human tumors. PMID- 4330463 TI - Human lymphoblastoid cell lines. I. Culture methods and examination for Epstein Barr virus. PMID- 4330464 TI - Comparison of activity and isozyme patterns of four enzymes from hepatomas of different growth rates. PMID- 4330465 TI - RNA tumor-virus antigen expression in chemically induced tumors. Virus-genome specified common antigens detected by complement fixation in mouse tumors induced by 3-methylcholanthrene. PMID- 4330466 TI - Comparative morphology of avian and murine leukemia viruses. PMID- 4330467 TI - Change in growth and morphology of fibroblasts by prostaglandins. PMID- 4330468 TI - [Acute cyanhydric poisoning and its emergency treatment]. PMID- 4330469 TI - The cholinergic synapse and the site of memory. AB - A simple hypothesis can explain the results obtained to date if we disregard those results when we wait 30 minutes after original learning to inject. The hypothesis is that, as a result of learning, the postsynaptic endings at a specific set of synapses become more sensitive to transmitter. This sensitivity increases with time after initial learning and then declines. The rate at which such sensitivity increases depends on the amount of initial learning. If the curve of transmission plotted against time is displaced upward with anticholinesterases then the very low portions will show facilitation, and the high portions will cause block (Fig. 8). The middle portions will appear unaffected (unless special experimental tests are made). If the curve of transmission is displaced down with anticholinergics, then the middle portion will appear unaffected and only the very early or late components will show block. The results are evidence that synaptic conductance is altered as a result of learning. So far it seems (i) that cholinergic synapses are modified as a result of learning and that it probably is the postsynaptic membrane that becomes increasingly more sensitive to acetylcholine with time after learning, up to a certain point. (ii) After this point, sensitivity declines, leading to the phenomenon of forgetting. (iii) There is also good evidence that there is an initial phase of declining sensitivity to cholinesterase or increasing sensitivity to anticholinergics. This could reflect the existence of a parallel set of synapses with fast decay that serve as a shortterm store. (iv) Increasing the amount of learning leads to an increase in conductance in each of a set of synapses without an increase in their number. (v) Both original learning and extinction are subserved by cholinergic synapses. PMID- 4330470 TI - Simultaneous detection of reverse transcriptase and high molecular weight RNA unique to oncogenic RNA viruses. AB - The simultaneous assay of the reverse transcriptase and 60S to 70S RNA of oncogenic RNA viruses is described. The virus can be detected at low concentrations in biological fluids containing enzymatically active cell fragments or other contaminants. The fact that two features diagnostic of the oncornaviruses are used in the tests increases the certainty with which a positive outcome can be interpreted. PMID- 4330471 TI - Activation of spontaneous murine leukemia virus-related antigen by lymphocytic choriomeningitis virus. AB - Persistent infection with lymphocytic choriomeningitis (LCM) virus activates a phenotypic expression of murine leukemia viruis-related antigen. NZB and (NZB x NZW)F(1) mice, which normally carry large amounts of Gross virus, and C57BL/6 and NZW mice, which normally carry little virus, were infected with LCM virus. All had Gross soluble antigen in their plasmas at 3 months of age, while noninfected matched controls of all strains did not. This effect was seen after infection with LCM virus that was tissue passed or plaque purified. Similarly, cultures of mouse-embryo fibroblasts produced Gross soluble antigen when infected with LCM virus, but noninfected cultures failed to do so. PMID- 4330472 TI - [Protein fractions and phosphomonoesterases isoenzyme activities in plasmocytoma, Waldenstrom disease and Sjogren's syndrome patients. 7. Thin-layer electrophoresis in starch gel]. PMID- 4330473 TI - Active immunotherapy. PMID- 4330474 TI - The investigation of oncogeic viral genomes in transformed cells by nucleic acid hybridization. PMID- 4330475 TI - Viral genome and oncogenic transformation: nuclear and plasma membrane events. PMID- 4330476 TI - Epidemiologic observations of virus infections in a closed population of young children. PMID- 4330477 TI - Seroepidemiology of infectious due to members of the herpesvirus group. PMID- 4330478 TI - Factitious hypoglycemia. Why not diagnose before laparotomy? PMID- 4330480 TI - Mucoid adenocarcinoma in anorectal fistula. PMID- 4330479 TI - Maturation disparity between hand-wrist bones in Hong Kong Chinese children. PMID- 4330481 TI - Effect of the partial constriction of portal vein on renal hypertension in the rat. PMID- 4330482 TI - Radio-fibrinogen studies in renal hypertension. PMID- 4330483 TI - Metabolic effects of epinephrine, dibutyryl cyclic AMP, and glucagon infused intravenously into normal dogs. PMID- 4330484 TI - Cyclic adenosine monophosphate, cyclic guanosine monophosphate, and glucagon: effects on membrane potential and ion fluxes in the liver. PMID- 4330485 TI - Methods of assay of cyclic nucleotides. PMID- 4330486 TI - Adrenergic receptors and cyclic AMP in the regulation of human adipose tissue lipolysis. PMID- 4330487 TI - Effects of phosphodiesterase inhibitors on cyclic AMP levels and on lipolysis. PMID- 4330488 TI - Activated lipolysis and pH changes. PMID- 4330489 TI - Cyclic AMP and histone phosphorylation. PMID- 4330490 TI - On the reactivity and mechanism of action of cyclic nucleotides. PMID- 4330492 TI - The isolation of a receptor for adenosine 3',5'-cyclic monophosphate (cAMP) from the adrenal cortex: the role of the receptor in the mechanism of action of cAMP. PMID- 4330491 TI - ACTH-receptor interaction in the adrenal: a model for the initial step in the action of hormones that stimulate adenyl cyclase. PMID- 4330493 TI - Mechanism of activation of a rabbit reticulocyte protein kinase by adenosine 3',5'-cyclic monophosphate. PMID- 4330494 TI - On the role of cyclic AMP in insulin release: I. Overall effects in cultured fetal rat pancreas. PMID- 4330495 TI - The role of cyclic AMP in the release of anterior pituitary hormones. PMID- 4330497 TI - Evidence for a role of cyclic AMP in the release of calcitonin. PMID- 4330496 TI - The formation and metabolism of cyclic GMP. PMID- 4330498 TI - Relation of cyclic AMP to the release and actions of prostaglandins. PMID- 4330499 TI - Introductory remarks: secretion and membrane function. PMID- 4330500 TI - Factors involved in the action of cyclic AMP on the permeability of mammalian kidney and toad urinary bladder. PMID- 4330501 TI - Cyclic AMP and sodium transport in frog skin. PMID- 4330502 TI - The role of cyclic AMP in gastric secretion. PMID- 4330503 TI - Cyclic nucleotide phosphodiesterase and cyclic AMP. PMID- 4330504 TI - The possible role of cyclic AMP in some actions of cholera toxin. PMID- 4330506 TI - Control of reactions related to enzyme secretion in rat parotid gland. PMID- 4330505 TI - Hormones and other factors regulating calcium metabolism. PMID- 4330507 TI - Cyclic AMP-treated sarcoma cells acquire several morphological characteristics of normal fibroblasts. PMID- 4330508 TI - On the role of cyclic AMP in immune responses. PMID- 4330510 TI - Derivatives and analogues of cyclic nucleotides. PMID- 4330509 TI - Excitation and response in muscular tissues. PMID- 4330511 TI - Cyclic AMP in skeletal muscle. PMID- 4330512 TI - Cyclic AMP and smooth muscle function. PMID- 4330513 TI - The role of cyclic AMP in platelet function. PMID- 4330514 TI - On the role of cyclic AMP in the function of skin melanophores. PMID- 4330515 TI - On the regulation of adenyl cyclase activity in the rat pineal gland. PMID- 4330516 TI - Extracellular cyclic nucleotides. PMID- 4330517 TI - Formation and metabolism of cyclic AMP in the mammalian central nervous system. PMID- 4330518 TI - Cyclic AMP mediation of norepinephrine inhibition in rat cerebellar cortex: a unique class of synaptic responses. PMID- 4330519 TI - Cyclic AMP and the function of eukaryotic cells: an introduction. PMID- 4330520 TI - A new nomenclature for kinase phosphatase catalyzed interconvertible enzymes. PMID- 4330521 TI - Glycogen metabolism and the mechanism of action of cyclic AMP. PMID- 4330522 TI - The role of cyclic AMP in the interaction of glucagon and insulin in the control of liver metabolism. PMID- 4330523 TI - Chemotherapy of cytomegalovirus infections. Further results on intraperitoneal infection of Ehrlich ascites tumor mice with viruses of low virulence in vivo: MCMV-Smith, adenovirus 2, RSV-Long and rhinoviruses. PMID- 4330524 TI - Sympathetic-parasympathetic interactions in the heart. PMID- 4330525 TI - A plasma humoral factor of extrarenal origin causing release of reninlike activity in hypotensive dogs. PMID- 4330526 TI - Activation of phosphorylase by cyclic AMP without augmentation of contractility in perfused guinea pig heart. PMID- 4330527 TI - Influence of sodium and potassium content on arterial responsiveness. PMID- 4330528 TI - A method for the preparation of radioactive FSH with preservation of biologic activity. PMID- 4330529 TI - Stimulation by ICSH of protein biosynthesis in isolated Leydig cells from hypophysectomized rats. PMID- 4330530 TI - The inhibition of the soluble human placental 17-beta-hydroxysteroid dehydrogenase by o,p -DDD and its analogs. PMID- 4330531 TI - Evidence for central adrenergic neural inhibition of ACTH secretion in the rat. PMID- 4330533 TI - Role of the renin angiotensin system on the biosynthesis of aldosterone. PMID- 4330532 TI - Effect of mercury on response of isolated fat cells to insulin and lipolytic hormones. PMID- 4330534 TI - Age-dependent lipolytic activity of the rat myocardium in relation to its triglyceride content: possible new factor in ischaemic heart disease? PMID- 4330536 TI - [Pathogenicity of herpesvirus hominis type 2 for rabbit cornea]. PMID- 4330535 TI - The digestibility of subcutaneous adipose tissue from women of different ages. PMID- 4330537 TI - Sequence of eruption of permanent teeth and epiphyseal union in New World monkeys. PMID- 4330538 TI - Estriol conjugates in amniotic fluid in normal pregnancies and Rh isoimmunization. PMID- 4330539 TI - [Clinical and electromyographical diagnosis of damage to the peripheral nervous system by local vibrations]. PMID- 4330540 TI - "De novo" synthesis of cellulase' induced by sophorose in Trichoderma viride cells. PMID- 4330541 TI - Enzymatic isomerization of -methylmate to (-)citramalate by a soil bacterium. PMID- 4330542 TI - Conditioned drinking produced by procaine, NaCl, and angiotensin. PMID- 4330543 TI - [Inclusion cytomegaly in adults (literature review)]. PMID- 4330545 TI - [Enzymatic galactose determination without deproteinization and centrifugation in very small blood samples (10 mul)]. PMID- 4330546 TI - Metabolism of alkane by yeast. PMID- 4330544 TI - [The pathogenesis of myasthenia gravis as an immunological problem]. PMID- 4330548 TI - Metabolism of ceramide phosphorylethanolamine, phosphatidylinositol, phosphatidylserine and phosphatidylglycerol by housefly larvae. PMID- 4330549 TI - Tumor-producing viruses. PMID- 4330547 TI - The effect of undernutrition on the development of myelin in the rat central nervous system. PMID- 4330550 TI - Cell-free studies on the regulation of the arabinose operon. PMID- 4330551 TI - Arabinose C protein: regulation of the arabinose operon in vitro. PMID- 4330552 TI - Excitation of supraoptic neurosecretory cells by angiotensin II. PMID- 4330553 TI - Auditory sensitivity of the crickets Teleogryllus commodus and T. oceanicus. PMID- 4330554 TI - Renal damage in murine infection with reovirus 3: an ultrastructural study. PMID- 4330556 TI - Metastasizing chondroid syringoma: case report. PMID- 4330555 TI - Induction of liver tumours in the guinea pig by feeding dimethylnitrosamine. PMID- 4330557 TI - An electron microscopic study of giant cytosegresomes in acute liver injury due to heliotrine. PMID- 4330558 TI - Chronic obstructive jaundice induced by Reovirus type 3 in weanling mice. PMID- 4330559 TI - Cytoplasmic crystalline aggregates in murine pancreatic acinocytes. PMID- 4330560 TI - [Capillary skin lesions in diabetics]. PMID- 4330562 TI - [Possible mechanisms of disorders of cardiovascular activity in patients with Itsenko-Cushing syndrome and with corticosteromas]. PMID- 4330561 TI - [Some characteristics of the biosynthesis and metabolism of adrenal cortex hormones at different periods of childhood (literature review)]. PMID- 4330563 TI - [Glucocorticoid function of the adrenal cortex in hypothalamo-hypophyseal obesity]. PMID- 4330564 TI - [Some data on the nature of cortisol metabolism in macaca rhesus monkeys and hamadryas baboons]. PMID- 4330565 TI - [Some regularities in the development of compensatory hypertrophy of the adrenal glands at various periods following hemiadrenalectomy]. PMID- 4330567 TI - [Change in the rhythm of serum corticosterone and glycemia in rats under stress and hormone effects]. PMID- 4330566 TI - [Participation of the vagus nerves in regulation of the adrenal cortex function]. PMID- 4330568 TI - [Study of the processes of binding of corticosteroids with plasma transcortin in hypophyseal-adrenal diseases]. PMID- 4330569 TI - [Clinical trials with a new synthetic ACTH of prolonged action: Cortrosine Depot]. PMID- 4330570 TI - [Herniated disks and entrapment neuropathy of the dorsal branches of the lumbar and sacral spinal nerves]. PMID- 4330571 TI - Intrarenal formation of angiotensin I. AB - In 5 patients and 16 dogs the mean concentration of angiotensin I, but not II, was higher in the plasma of the renal vein than in the plasma of the renal artery. The fact that I was higher in the vein than in the artery supports the concept that I is formed in the renal vasculature. In the vein the mean concentration of I was 45 times higher than that of II. The probable formation of angiotensin I within the kidney and its high concentration in the renal vein suggest that if the renin angiotensin system plays a role in the regulation of intrarenal blood flow, then angiotensin I may be the major effector hormone in this process. PMID- 4330572 TI - [Detection of permeation changing factors in the course of an experimental inflammation by means of the radiogold test]. PMID- 4330573 TI - Lipolysis and glucose tolerance in obese subjects during prolonged starvation. PMID- 4330574 TI - Transmission of the sympathetic nervous impulse during pregnancy. PMID- 4330575 TI - Comments on the histological typing of lung tumours. PMID- 4330576 TI - Dopamine binding in a transplantable islet cell tumour of golden hamster. PMID- 4330577 TI - Spin-label studies of cooperative oxygen binding to hemoglobin. PMID- 4330578 TI - Oscillatory phenomena in biochemistry. PMID- 4330579 TI - Transients and relaxation kinetics of enzyme reactions. PMID- 4330580 TI - Metabolic role of vitamins A and D. PMID- 4330581 TI - Applications of nuclear magnetic resonance spectroscopy to the study of macromolecules. PMID- 4330582 TI - The biological significance of purine salvage. PMID- 4330583 TI - Granular degeneration of appendiceal smooth muscle. PMID- 4330584 TI - Histogenic classification of salivary tumors. PMID- 4330585 TI - Tissue isoantigens A,B, and H in carcinoma of the stomach. PMID- 4330586 TI - Cytochemical studies on leucocyte in children. I. Changes of neutrophil alkaline phosphatase activity in infectious diseases and following immunizations. PMID- 4330588 TI - Regeneration of the gastric epithelia in mice. An electron microscopic study. PMID- 4330587 TI - Cytochemical studies on leucocyte in children. II. Changes of lymphocytic cytochemical activities of periodic acid Schiff reaction and lactic dehydrogenase in infectious diseases and following immunizations. PMID- 4330589 TI - A stereoselective synthesis of 6-phthalimido-5-epipenicillanates. PMID- 4330590 TI - The management of inflammatory carcinoma of the breast. PMID- 4330591 TI - Perspectives on oncogenesis: does immunity stimulate or inhibit neoplasia? PMID- 4330592 TI - The eye as a mirror to neurologic disease. PMID- 4330593 TI - Peroxidase deficiency in familial goiter with iodide organification defect. PMID- 4330594 TI - Threat of resurgent polio. PMID- 4330595 TI - Clinical and immunological response of infants and children to administration of low-temperature adapted respiratory syncytial virus. PMID- 4330596 TI - Hyperglycaemic non-ketotic coma following surgically treated acromegaly in a non diabetic. PMID- 4330597 TI - [Derangement of clinical manifestations of hypoglycemia in patients with insuloma and diabetes mellitus]. PMID- 4330598 TI - [Stimulation of the hypothalamo-hypophyseal adrenal system in the complex treatment of rheumatic fever]. PMID- 4330599 TI - Renin response to diazoxide stimulation in experimental coarctation of the aorta. PMID- 4330601 TI - Electron spin resonance spectrometry and the determination of organ viability. PMID- 4330600 TI - The role of cyclic adenosine 3',5' monophosphate in gastric secretion. PMID- 4330602 TI - Actinomycin D--the drug of choice for initial therapy of gestational trophoblastic disease. PMID- 4330603 TI - Cancer chemotherapy based on the measurement of a tumor specific antigen. PMID- 4330604 TI - Presynaptic facilitation secondary to small fiber stimulation. PMID- 4330605 TI - Bone collagenase in assessment of the clinical course of metabolic bone disease. PMID- 4330606 TI - Cyclic adenosine 3', monophosphate 5', thyrocalcitonin, parathyroid hormone, and the isolated perfused bone. PMID- 4330607 TI - Inactivation of angiotensin II by the liver. PMID- 4330608 TI - An in vivo study of cellular and humoral tumor immune mechanisms. PMID- 4330609 TI - [A case of chemodectoma of the posterior mediastinum]. PMID- 4330610 TI - The fine structure of the type 2 cells in the Malpighian tubules of the stick insect, Carausius morosus. PMID- 4330611 TI - [The larval ecdysial glands of Tenebrio molitor L. (Tenebrionidae, Coleoptera) and their changes within a moulting cycle]. PMID- 4330612 TI - Formation of autophagic vacuoles during human corpus luteum involution. PMID- 4330614 TI - Histochemical demonstration of transmitter release from noradrenaline, dopamine and 5-hydroxytryptamine nerve terminals in field stimulated rat brain slices. PMID- 4330613 TI - Electron microscope studies on the development of the external zone of the mouse median eminence. PMID- 4330615 TI - [Fine structure of eosinophilic granulocytes in the domestic goose (Anser anser dom.)]. PMID- 4330616 TI - On the ultrastructure of neuro-epithelial interactions. The dermal innervation in the snout of the pig. PMID- 4330617 TI - [Electric organ of Gnathonemus (Mormyridae). Electroplaque and innervation]. PMID- 4330618 TI - [Rectal glands of the rabbit. Electron microscopy studies]. PMID- 4330619 TI - [Proliferation of the connective tissue related to age. 3. Cytophotometrical investigations]. PMID- 4330620 TI - [Reaction of in-vitro cultivated cells to short-term incubation with SiO 2 dust]. PMID- 4330621 TI - Further comparative characterization of rat liver mitochondrial and cytosol protein phosphatase. PMID- 4330622 TI - The sulphatase of ox liver. XV. Changes in the properties of sulphatase A in the presence of substrate. PMID- 4330623 TI - A soluble aspartate aminopeptidase from dog kidney. PMID- 4330624 TI - Pepsin insolubilized by covalent attachment to glass: preparation and characterization. PMID- 4330625 TI - Studies on extracellular proteins from Staphylococcus aureus. VI. Production and purification of -haemolysin in large scale. PMID- 4330626 TI - Studies on extracellular proteins from Staphylococcus aureus. VII. Studies on haemolysin. PMID- 4330627 TI - Molecular characteristics of the totally dependent and independent forms of glycogen synthase of rabbit skeletal muscle. I. Preparation and characteristics of the totally glucose 6-phosphate dependent form. PMID- 4330628 TI - Phospholipase A 1 activity of guinea pig pancreas. PMID- 4330629 TI - [Carbohydrate contents of phytohemagglutinin from Robinia pseudo acacia and their role in the erythro agglutinating activity]. PMID- 4330630 TI - Hemoglobin M Saskatoon: further data on biophysics and oxygen equilibrium. PMID- 4330631 TI - Electron paramagnetic resonance studies on the reaction of exogenous ligands with cytochrome c 3 from Desulfovibrio vulgaris. PMID- 4330632 TI - Lysosomal and nonlysosomal enzyme activities of Morris hepatomas. PMID- 4330633 TI - Cytotoxicity of sesquiterpene lactones. PMID- 4330634 TI - Antigenic cross-reactivity between primary spontaneous mouse mammary tumors and their transplantable ascites tumors. PMID- 4330635 TI - Chronological appearance of alkaline phosphatase activity in virus-induced thymic lymphomas of C57BL-6 mice. PMID- 4330636 TI - Use of carbenicillin and polymyxin B for therapy of gram-negative bacilli infections. PMID- 4330637 TI - Titration of equine infectious anemia virus. Effect of dosage on incubation time and clinical signs. PMID- 4330638 TI - [Special cases in the intraocular tumor diagnosis. Clinical aspects of primary intraocular manifestations of extraocular tumors and clinical diagnostic errors of secondary intraocular tumors]. PMID- 4330639 TI - Characterization of collagenolytic activity in the ulcerating cornea. PMID- 4330640 TI - [Early stages of tumors in the central nervous system. Experimental morphological studies]. PMID- 4330641 TI - [Ultrastructure of experimental brain tumors in rabbits]. PMID- 4330642 TI - [Study on the histopochemistry of oxidative enzymes in thioacetamide induced liver cirrhosis in mice]. PMID- 4330643 TI - [Daytime-dependent changes of membrane permeability in liver cell nuclei of the rat]. PMID- 4330644 TI - [Histochemical studies on the stimulation conducting system of the heart under normal and pathological conditions]. PMID- 4330645 TI - [Circadian changes in the nuclear membranes of rat liver cells following diethylnitrosamine administration]. PMID- 4330646 TI - [Synthesis of liphophilic substituted ACTH-peptides]. PMID- 4330647 TI - ESR measurement of short-lived free radicals obtained by addition of OH to DL methionine. PMID- 4330648 TI - [Analysis of the physiological mechanisms of the effect of corticosteroids on interneuronal transmission of excitation in an autonomic synapse]. PMID- 4330649 TI - Some endocrine effects on fighting behavior in isolated male albino mice. PMID- 4330650 TI - Effects of corticotrophin and dexamethasone on the levels of corticosteroids, adrenaline and noradrenaline in the adrenal glands of cats. PMID- 4330651 TI - Some effects of thyroxine on bovine hepatic intermediary metabolism. PMID- 4330652 TI - Effect of corticotrophin (Synacthen, Ciba) on compartmental arrangement of steroids in the rat adrenal cortex. PMID- 4330653 TI - Effect of growth hormone on the aldosterone secretory response to sodium restriction in corticotrophin-maintained hypophysectomized nephrectomized rats. PMID- 4330654 TI - A radioimmunoassay for rat plasma corticotrophin. PMID- 4330655 TI - Intracellular localization of progesterone in tissues of the foeto-placental unit. PMID- 4330656 TI - A phylogenetic study of pituitary corticotrophic activity. PMID- 4330657 TI - The effect of dexamethasone on the distribution of 131 I-labelled 1-24 corticotrophin in the intact guinea-pig. PMID- 4330658 TI - Pituitary control of sebum secretion in the rat. PMID- 4330659 TI - Shock-induced release of the preputial gland secretions that eleicit fighting in mice. PMID- 4330660 TI - The effects of thyrotrophin-releasing hormone in man. PMID- 4330661 TI - Effect of masking by light on the apparent contrast of flashed gratings. PMID- 4330662 TI - [Clinical evaluation of rifampicin for pulmonary tuberculosis. 3. A controlled trial on the clinical effects of chemotherapy with rifampicin-ethambutol and viomycin-ethambutol in retreatment cases of pulmonary tuberculosis]. PMID- 4330663 TI - [Biochemical diagnosis of tumors of the autonomic nervous system]. PMID- 4330664 TI - [Plant agglutinin- and PPD tuberculin-stimulated lymphocyte transformation in vitro in patients with disseminated sclerosis]. PMID- 4330665 TI - [Rathke-pouch tumors in adolescents and adults in the records of the Department of Neurosurgery in Cracow]. PMID- 4330666 TI - The management of Wilms' tumour. PMID- 4330667 TI - [Enteroviruses in swimming pool water]. PMID- 4330668 TI - [Our experience with 420 stereotaxic surgical operations]. PMID- 4330669 TI - [Disintegration effects of sodium hexametaphosphate on the structure of human gallstone, with special reference to soft x-ray findings]. PMID- 4330670 TI - Interaction between compound F 6066 (Sexovid, cyclofenil NFN) and progesterone in the pregnancy maintenance test and on deciduoma formation in mice. PMID- 4330672 TI - Neutralizing antibody in serum and nasal secretions of calves exposed to parainfluenza-3 virus. PMID- 4330671 TI - In vitro enzymatic activity and 14 C-glucose metabolic studies with caprine and canine brain homogenates. PMID- 4330673 TI - Relationship of serum and nasal secretion-neutralizing antibodies in protection of calves against parainfluenza-3 virus. PMID- 4330675 TI - Pathogenesis of Sendai virus infection in mice. PMID- 4330674 TI - Identification of selected animal viruses with fluorescent antibodies prepared from multivalent antiserums. PMID- 4330676 TI - Hepatitis-associated antigen and hepatocellular carcinoma in Taiwan. PMID- 4330677 TI - Simplified assessment of pituitary-adrenal reserve. Measurement of serum 11 deoxycortisol and cortisol after metyrapone. PMID- 4330678 TI - The renin-angiotensin system and hypertension. PMID- 4330679 TI - Another zoonosis from monkeys: tanapox. PMID- 4330680 TI - [Resection of tympanic plexus in Frei's syndrome and recurrent parotiditis]. PMID- 4330681 TI - [Nasopharyngeal fibroma]. PMID- 4330682 TI - [Anatomo-clinical aspects of cytomegalic disease in adults. Apropos of 2 cases]. PMID- 4330683 TI - Antibodies in human and monkey sera to herpes-type virus from a chicken with Marek's disease and to EB virus detected by the immunofluorescence test. PMID- 4330684 TI - Studies on the characteristics of a herpes-type virus isolated from a chicken with Marek's disease. PMID- 4330685 TI - Electron microscopic observations on FL cells infected with herpes simplex virus. I. Viral forms. PMID- 4330686 TI - Induction and repression of an extracellular proteinase in Vibrio parahaemolyticus. PMID- 4330687 TI - Semiochemical--structure and function. PMID- 4330688 TI - A simple method for the fluorimetric estimation of testosterone in human male plasma. PMID- 4330689 TI - Determination of urinary 3-methoxy-4-hydroxymandelic acid by gas-liquid chromatography as vanillyl alcohol. PMID- 4330691 TI - [Protein conformation and lipid-protein interaction in mitochondria and endoplasmic reticulum membranes of the liver of intact rats and rats with induced Zajdela hepatoma]. PMID- 4330690 TI - Arylsulphatase activity of human lung, liver and kidney neoplasms. PMID- 4330692 TI - Pleomorphic adenoma with bone and bone marrow formation. PMID- 4330693 TI - Pleomorphic adenoma of hard palate. CAse report. PMID- 4330694 TI - Vincristine neuropathy--a case report. PMID- 4330695 TI - Effects of divalent ions and drugs on synaptic transmission in phasic electroreceptors in a mormyrid fish. AB - We recorded impulses in afferent nerve fibers innervating two kinds of phasic electroreceptors in a mormyrid fish. We used an isolated preparation of skin, receptors, and sensory nerves to estimate synaptic delays, and to change solution in contact with the receptor-nerve synapse. The minimum delays between stimuli and sensory nerve responses, which must be slightly larger than synaptic delays, are about 0.7 msec in medium receptors and about 0.25 msec in large receptors. This result supports previous suggestions that transmission is chemically mediated in medium receptors and electrically mediated in large receptors. Furthermore, Mg(+2) depresses synaptic transmission in medium receptors, and has little effect on transmission in large receptors. A complex dependence of response on both Mg(+2) and Ca(+2) masks divalent ion dependence of transmission, but a large excess of Mg(+2) cannot completely block transmission in medium electroreceptors. L-glutamate, and not cholinergic drugs, produces a sequence of excitation and depression of medium receptor response which indicates that a similar chemical is the transmitter in the afferent synapse. PMID- 4330696 TI - Studies in prebiotic synthesis. IV. Conversion of 4-aminoimidazole-5-carbonitrile derivatives to purines. PMID- 4330697 TI - Genetically and chemically derived missense suppressor transfer RNA's with altered enzymic aminoacylation rates. PMID- 4330699 TI - Custering of the morphological components of perinatal telencephalic leucoencephalopathy. AB - The data upon which the original report of perinatal telencephalic leucoencephalopathy was based have been examined for clustering of the four criteria of neonatal white matter damage. Three clusters have been identified: (1) acutely damaged glia with amphophilic globules, (2) hypertrophic astrocytes and amphophilic globules but without necrotic foci, and (3) hypertrophic astrocytes and amphophilic globules with necrotic foci. The original report of perinatal telencephalic leucoencephalopathy therefore probably included two entities. One was characterized by acutely damaged glia and amphophilic globules and the other by hypertrophic astrocytes and amphophilic globules. The two entities do not occur together significantly more frequently than would be expected on the basis of the independent occurrence of each. PMID- 4330698 TI - Idiopathic polyneuritis: serial studies of nerve and immune functions. AB - The clinical features of idiopathic polyneuritis in 22 patients admitted to the University of Kentucky Medical Center between July 1965 and June 1970 are described. Serial studies of peripheral nerve function in 12 patients followed to clinical recovery showed changes in nerve conduction velocity, distal motor latency, and/or muscle action potential amplitude. Six children and one adult, showing a change in all three parameters, exhibited a strong correlation between the degree of slowing and the shortness of their illness. Assessment of immune status, by quantitative measurement of cerebrospinal fluid immunoglobulin G(11 patients) and by the degree of lymphocyte transformation on exposure to specific brain protein and/or a homogenate of sciatic nerve (10 patients), bore no consistent relation to the severity or course of the illness. A double-blind trial of short-term, high dose adrenocorticotrophic hormone has yielded no valid evidence to date for or against the effectiveness of such therapy in this illness. PMID- 4330700 TI - [Human growth hormone estimations in the differential diagnosis of chromophobe and eosinophil pituitary adenomas]. PMID- 4330701 TI - Myopathy with leukemoid reaction secondary to alveolar-bronchiolar cell carcinoma. PMID- 4330702 TI - Peripheral neuropathy in chlorobiphenyl poisoning. PMID- 4330703 TI - A peroneal muscle stretch reflex. PMID- 4330705 TI - Sleeping behaviour in abnormal newborn infants. PMID- 4330704 TI - Sleep studies for the neurological assessment of the newborn. PMID- 4330706 TI - [Antigens of Bordetella pertussis and their repercussion in immunization programs against whooping cough]. PMID- 4330707 TI - [Pulmonary findings in viral infections]. PMID- 4330709 TI - [Hyperosmolar coma in diabetics]. PMID- 4330708 TI - [Statistical considerations on the damage or the integrity of hematopoietic organs (bone marrow, lymph nodes, spleen and liver) during chronic lymphoid leukemia. (Study of 365 personal cases)]. PMID- 4330710 TI - [Suicide]. PMID- 4330711 TI - [Comparative histological and cytological diagnosis of malignant lung tumors with special reference to alveolar-cell-carcinoma]. PMID- 4330712 TI - [Results of surgical treatment of bronchial neoplasms in a Pulmonary Clinic]. PMID- 4330713 TI - [Swine ovary cell culture in virologic routine workshop. Short communication]. PMID- 4330714 TI - Fine structure of the posterior salivary gland of Eledone cirrosa and Octopus vulgaris. PMID- 4330715 TI - Fine structure and its functional properties of the ependymal cell in the frog median eminence. PMID- 4330716 TI - Ultrastructure of human amnion and amniotic plaques of normal pregnancy. PMID- 4330717 TI - [Comparative studies of the olfactory epithelium, especially the vomero-nasal (Jacobson's) organ in amphibia, reptiles, and mammals]. PMID- 4330718 TI - [Ultrastructure of invertebrate hemocytes. V. Hemocytes of Astacus astacus (L.) (Crustacea)]. PMID- 4330719 TI - [Various aspects of coronary disease observed in African Negroes at Abidjan]. PMID- 4330720 TI - Serum -hydroxybutyrate dehydrogenase activity: an improved method. PMID- 4330721 TI - A study on purified bovine erythrocuprein. PMID- 4330722 TI - Optical and magnetic measurements of horseradish peroxidase. I. Azide complex of peroxidase. PMID- 4330723 TI - Optical and magnetic measurements of horseradish peroxidase. II. pH dependence of peroxidase. PMID- 4330724 TI - Isolation of lysinoalanine from the protein-polysaccharide complex of cartilage after alkali treatment. PMID- 4330725 TI - Selective condensation of plasma kinins from biological fluids with siliconised silica gel. PMID- 4330727 TI - Genetic control of enzyme structure in hyperuricemia. PMID- 4330729 TI - [New biologically active copolymers of N-vinylpyrrolidone]. PMID- 4330726 TI - Muscle relaxants: advances in the last decade. PMID- 4330730 TI - [Characteristics of the reactions of neurons in different sections of the turtle forebrain to light stimuli]. PMID- 4330728 TI - Anaerobic phosphorylation in Ascaris mitochondria and the effects of anthelmintics. PMID- 4330731 TI - [Action of certain oxidases and dehydrogenases in the juxtaglomerular apparatus of the rat kidney]. PMID- 4330732 TI - [Histochemical studies of female genitalia during fetal development. 3. Carbohydrate histochemistry of the ovary]. PMID- 4330733 TI - A spin label investigation of the active site of an enzyme. Bovine carbonic anhydrase. PMID- 4330734 TI - Regulation and mechanism of phosphoribosylpyrophosphate synthetase: repression by end products. AB - Phosphoribosylpyrophosphate (PRPP) synthetase participates in the biosynthesis in bacteria of purine nucleotides, pyrimidine nucleotides, tryptophan, and histidine. The regulation of the synthesis of PRPP synthetase in Salmonella typhimurium was studied. Addition of end products to the growth medium, singly or in combination, resulted in small decreases in the specific activity of PRPP synthetase, but levels of the enzyme were never decreased to less than half of those found when the bacteria were grown on minimal medium. Growth of the bacteria on several different carbon sources or starvation for phosphate had little effect on the specific activity of PRPP synthetase. Over-production of histidine in a histidine regulatory mutant, which would be expected to result in a depletion of intracellular PRPP pools, did not alter PRPP synthetase specific activity. PRPP synthetase levels were examined in auxotrophic strains of S. typhimurium that had been starved for the end products of PRPP. In each case derepression of an enzyme in the biosynthetic pathway for the limiting end product was demonstrated. However, only alterations in the levels of pyrimidine bases in the culture medium brought about derepression and repression of PRPP synthetase. Excess pyrimidines do not completely repress the enzyme. Deprivation of exponentially growing cells for pyrimidines by growth of an auxotrophic mutant on media containing orotic acid, which enters the cells slowly, resulted in a 10 fold derepression of PRPP synthetase. Derepression of PRPP synthetase during uracil starvation was prevented by chloramphenicol. The PRPP synthetase activities of extracts from repressed and derepressed cells responded in identical fashion to heat inactivation, cellulose acetate electrophoresis at several pH values, and in kinetic experiments. PMID- 4330735 TI - Nicotinamide deamidation by microorganisms in rat stomach. AB - We have extended our investigation of nicotinamide deamidation in the stomach of conventional rats. The bacterial species in the pars preventricularis were identified as Flavobacterium peregrinum, Escherichia coli, Streptococcus faecalis, and Lactobacillus acidophilus, listed in order of decreasing deamidase activity. Nicotinamide-7-(14)C ingested into rat stomach was rapidly deamidated to nicotinic acid. These results contribute to the accumulated evidence that microorganisms present in the pars preventricularis of rat stomach are responsible for the deamidation of nicotinamide to nicotinic acid, a known precursor of mammalian pyridine nucleotides. PMID- 4330736 TI - Confirmation of the identification of the major C-29 hydrocarbons of Sarcina lutea. AB - Although there is agreement on the fact that Sarcina lutea strain FD-533 has branched C-29 monoalkenes as major hydrocarbon components, there is disagreement in the literature as to the nature of the branching. This has been resolved by analyses of the fatty acids produced by permanganate-periodate treatment of each of the resolvable hydrocarbon fractions making up the C-29 complex. The three major components are identified as doubly branched, Delta(13) species with two iso terminations, one iso and one anteiso termination, and two anteiso terminations. PMID- 4330737 TI - Nucleotide metabolism during differentiation in Dictyostelium discoideum. AB - Energy metabolism in Dictyostelium discoideum was studied by following the incorporation of [(3)H]adenine and [(32)P]Pi into the intracellular adenine nucleotides at two stages of differentiation. That the levels of nucleotides measured represented levels present in vivo was shown by demonstrating that the concentrations determined from cells quickly frozen in liquid nitrogen were identical to those from cells harvested and subsequently killed in perchloric acid. In addition, significant compartmentalization among the nucleoside triphosphates was not observed after 30 min, since uridine triphosphate, guanosine triphosphate, and adenosine triphosphate (ATP) were at radioactive equilibrium after exposure to [(32)P]Pi. At the sorocarp stage of differentiation, the dominant role of adenylate kinase activity is indicated by the observations that (i) adenylate kinase activity was found to be present, (ii) the specific radioactivities of the beta- and gamma-phosphates of ATP were equal, (iii) the increase in specific radioactivity of adenosine diphosphate was one half that of ATP in the presence of [(32)P]Pi, and (iv) the steady-state equilibrium constant calculated (0.69) from the nucleotide levels equaled that of the apparent equilibrium constant reported in the literature (0.70). By using the same criteria, adenylate kinase activity was not the predominant reaction establishing the adenine nucleotide levels in cells at the pseudoplasmodium stage of differentiation. PMID- 4330739 TI - Histidine regulation in Salmonella typhimurium. 8. Mutations of the hisT gene. AB - The hisT gene, one of six genes in which mutation causes derepression of the histidine operon in Salmonella typhimurium, is shown to code for a protein that is not essential for the growth of the bacteria. This is indicated by the characterization of particular classes of mutations in the hisT gene: amber mutations, frame-shift mutations, and temperature-sensitive mutations that affect repression but not growth. In addition, the class of semilethal mutations was selected for but not found. PMID- 4330740 TI - Localization and solubilization of colicin receptors. AB - Envelope fractions isolated from Escherichia coli K-12 C600 and from colicin resistant and colicin-tolerant (Tol II) mutants derived from this strain were separated on sucrose gradients into cell wall-enriched and cytoplasmic membrane enriched fractions. These fractions were tested for their ability to neutralize colicins of the E and K groups. Neutralization activity was found in the cell wall-enriched fraction from the parent and the Tol II mutant but was absent from all fractions from the resistant mutant. This was also tested with several other E. coli strains. In all cases, sensitive strains contained the neutralization activity, whereas resistant strains did not. The neutralization activity was solubilized from cell walls or cell envelopes of sensitive or Tol II strains by extraction at room temperature with Triton X-100 plus ethylenediaminetetraacetic acid. The solubilized activity was precipitated by 20% ammonium sulfate, 70% ethanol, or 10% trichloroacetic acid. The activity was destroyed by treatment of the solubilized preparation with trypsin or periodate. These results suggest that this colicin-neutralization activity is due to the presence of specific receptors localized in the cell wall and that intact protein and a carbohydrate are required for this receptor to bind colicin. PMID- 4330738 TI - Altered deoxyribonucleic acid polymerase activity in a methyl methanesulfonate sensitive mutant of Bacillus subtilis. AB - Of six deoxyribonucleic acid repair mutants of Bacillus subtilis assayed for deoxyribonucleic acid polymerase, only the methyl methanesulfonate-sensitive and ultraviolet light-sensitive mutant JB1-49(59) has impaired polymerase activity. Extracts prepared by sonic treatment or gentle lysis had about 10% of the wild type activity with poly d(A-T), an alternating copolymer of deoxyadenylate and deoxythymidylate, used as template. The sensitivity to methyl methanesulfonate and ultraviolet light and the low level of polymerase activity transformed and reverted together, indicating that the two characteristics are a pleiotropic manifestation of a single mutation. Mixed extract and kinetic experiments mitigated against an altered nuclease activity as the enzymatic consequence of the mutation. Also, the mutant and wild type activities were stimulated equally by Escherichia coli exonuclease III. The residual activity in the mutant showed several differences from the wild-type activity: it purified differently, was more sensitive to sulfhydryl reagents, and displayed a different template specificity. We tentatively conclude that either the mutation in JB1-49(59) has introduced a qualitative as well as a quantitative change in the polymerase or the wild type contains two distinct polymerases, one of which is missing in the mutant. PMID- 4330741 TI - Antimicrobial actions of hexachlorophene: release of cytoplasmic materials. AB - Intracellular solutes were released from growing or resting cells of Bacillus megaterium as a consequence of hexachlorophene treatment. The effect was dose dependent, with the optimum at a concentration about sevenfold greater than the minimal lethal dose. The effects of pH and temperature on the leakage process also were inconsistent with the killing effects of the drug. The types of materials released appeared to be the same with or without hexachlorophene treatment. The released materials were small molecules which apparently derived from preexisting ribonucleic acid and protein, but not from deoxyribonucleic acid. Compared to the effects of other representative surface-active agents and other bis-phenols, hexachlorophene was superior in ability to cause leakage of intracellular materials. Different microorganisms varied in their susceptibility to hexachlorophene, with Pseudomonas aeruginosa and a paracolon isolate the most resistant of the vegetative cells examined. It was concluded that the release of intracellular solutes was an effect secondary to the lethal event and presumably arose from hexachlorophene-mediated stimulation of degradative enzymes. PMID- 4330742 TI - Extracellular nuclease in the genus Lactobacillus. AB - Several species and strains of lactobicilli, Bacillus coagulans, and Sporolactobacillus inulinus produced detectable amounts of extracellular nuclease which hydrolyzed ribonucleic acid and deoxyribonucleic acid. PMID- 4330743 TI - Extracellular lipid of Thiobacillus thiooxidans. AB - The extracellular lipid of Thiobacillus thiooxidans is a heterogeneous mixture of phospholipid and neutral lipid, primarily free fatty acids. PMID- 4330744 TI - Effect of 4-azaleucine upon leucine metabolism in Salmonella typhimurium. AB - dl-4-Azaleucine (5 x 3(-3)m) added to exponentially growing cells of Salmonella typhimurium resulted in an abrupt cessation of growth lasting 4 to 8 hr followed by a resumption of division. The transitory nature of inhibition was not due to the instability or modification of the analogue or to a derepression of leucine forming enzymes. Of many compounds tested, leucine served most efficiently to reverse 4-azaleucine-induced inhibition. Inhibition of growth can be explained by the fact that 4-azaleucine inhibits alpha-isopropylmalate synthase, the first enzyme unique to leucine biosynthesis. The analogue was a poor inhibitor of both the transamination of alpha-ketoisocaproate to leucine and the charging of leucine to transfer ribonucleic acid. With a leucine auxotroph starved for leucine, the analogue was incorporated into protein specifically in place of leucine. Such incorporation was accompanied by the death of almost all of the cells. PMID- 4330745 TI - Effects of prolactin, corticotrophin and cortisol on the adenohypophysis and interrenal gland of anadromous threespine sticklebacks, Gasterosteus aculeatus L. form trachurus, in winter and summer. PMID- 4330747 TI - [Cancer of the extra-hepatic bile ducts]. PMID- 4330746 TI - Putrefaction: a difficulty in forensic medicine. PMID- 4330748 TI - [Synthesis of substituted thiazolo-(3.2.-d)-tetrazolylium and thiazolo-(2.3.-b) thiazolylium salts]. PMID- 4330749 TI - [Unusual growth form and metastasis of a glioblastoma]. PMID- 4330751 TI - [Reflex-dystrophies and nerve lesions resulting from trauma of the limbs]. PMID- 4330750 TI - [Morbidity profile of a geriatric outpatient department]. PMID- 4330752 TI - The influence of imipramine, dexphenmetrazine and amphetaminsulphate upon the clinical and polygraphic picture of narcolepsy-cataplexy. PMID- 4330754 TI - [Differential diagnosis of infectious hepatitis and adenoviral diseases by the complement fixation reaction method]. PMID- 4330753 TI - [Antigenic difference between Rous sarcoma virus and normal cells used in growing the virus]. PMID- 4330755 TI - [Epitheliomatous (basaliomatous) phakomatosis]. PMID- 4330757 TI - Mechanism of transmitter release from nerve terminals. PMID- 4330756 TI - [The draining veins of vascular brain tumors in serial angiograms]. PMID- 4330758 TI - A review of pharmacological approaches to the acetylcholine receptors at the neuromuscular junction. PMID- 4330759 TI - Quantal components of end-plate potentials in the myasthenic syndrome. PMID- 4330760 TI - Leukemia virus and autoimmune disease of NZB mice. PMID- 4330762 TI - Antibiotic-induced neuromuscular blockade. PMID- 4330761 TI - A morphological explanation of the transmission defect in myasthenia gravis. PMID- 4330763 TI - The use of ACTH and corticosteroids in myasthenia gravis. PMID- 4330764 TI - The oxidation-reduction potentials of the hemes and copper of cytochrome oxidase from beef heart. PMID- 4330766 TI - Ethyl isocyanide complexes of bacterial cytochrome P-450. PMID- 4330765 TI - The effects of NaCl on the amino acid acceptor activity of rat liver tRNA. PMID- 4330767 TI - Metabolism of 25-hydroxycholecalciferol and its inhibition by actinomycin D and cycloheximide. PMID- 4330768 TI - Metabolic coupling and synchronization of NADH oscillations in yeast cell populations. PMID- 4330769 TI - [Electron microscopy for the detection of swine fever virus in lymph node cells of infected pigs]. PMID- 4330770 TI - [Isolation and identification of the virus of canine viral hepatitis in Bulgaria]. PMID- 4330771 TI - [Comparison of chemical methods for determining adrenal function in pigs by the excretion of steroid metabolites]. PMID- 4330772 TI - [Diagnosis and control of bovine enzootic leukosis. 4. Comparison of antibody formation following inoculation of the Riems concentrated foot-and-mouth disease vaccine in clinicially healthy and in pre-leukotic cattle]. PMID- 4330773 TI - [Amebic liver abscess. Apropos of 80 cases observed at the Abidjan U.H.C]. PMID- 4330774 TI - [Electron microscopic changes in toxically injured and proliferating liver cells due to long-term application of diethylnitrosamine]. PMID- 4330775 TI - Enhanced glycolipid: -galactosyltransferase activity in contact-inhibited hamster cells, and loss of this response in polyoma transformants. PMID- 4330776 TI - Actions of polyamines on lipid and glucose metabolism of fat cells. PMID- 4330777 TI - Phosphoenolpyruvate, a new inhibitor of phosphoribulokinase in pseudomonas facilis. PMID- 4330778 TI - [Histoenzymatic identification of hepatocytes in histotypic culture]. PMID- 4330779 TI - [Varying post-synaptic potentials in adjacent synapses in some multi-innervated (tonic) fibers of eye muscles]. PMID- 4330780 TI - Control of glycolysis in the lens. PMID- 4330781 TI - Studies on a new strain of Tetrahymena pyriformis, a hymenostome ciliate, parasitic in the gut of a snail, Viviparus bengalensis. PMID- 4330784 TI - A sensitive method for the biological assay of secretin. PMID- 4330783 TI - Fasting plasma gastrin levels in man. PMID- 4330782 TI - Progress report. Diagnosis of insulinoma. PMID- 4330785 TI - Effect of diazooxonorleucine and N-ethyl maleimide on the incorporation of nicotinic acid and nicotinamide into the pyridine nucleotides of human erythrocytes in vitro. PMID- 4330786 TI - Congenital cytomegalovirus infection in siblings from consecutive pregnancies. PMID- 4330787 TI - [Stenosing laryngotracheitis in childhood]. PMID- 4330788 TI - Rehabilitation: financing services. PMID- 4330789 TI - Differentiation between type 1 and type 2 strains of herpes simplex virus by an indirect immunofluorescent technique. PMID- 4330790 TI - Further studies on a purification procedure for encephalomyocarditis virus. PMID- 4330791 TI - Interferon clearance rate decreased after repeated injections. PMID- 4330792 TI - Differences in the properties of thymidine kinase produced in cells infected with type 1 and type 2 herpes virus. PMID- 4330793 TI - Cyclic 3',5'-adenosine monophosphate-stimulated protein kinase from human skin. PMID- 4330794 TI - Twenty-four-hour variations in DNA synthesis of a fast-growing and a slow-growing hepatoma: DNA synthesis rhythm in hepatoma. PMID- 4330795 TI - Stimulating influence of bacillus Calmette-Guerin on immunity to polyoma tumors and spontaneous leukemia. PMID- 4330797 TI - Susceptibility of unfertilized and fertilized mouse eggs to simian virus 40 and Moloney sarcoma virus. PMID- 4330796 TI - Biochemical and tissue culture studies of transplantable mouse hepatomas H-4, H 6, and BW7756. PMID- 4330798 TI - Lasting influence of early caloric restriction on prevalence of neoplasms in the rat. PMID- 4330799 TI - Toxicity and antitumor activity of gallium nitrate and periodically related metal salts. PMID- 4330800 TI - Seroepidemiologic studies of herpesvirus type 2 and carcinoma of the cervix. I. Case-control matching. PMID- 4330801 TI - Comparative immunogenicity of various cellular and cell-free preparations in a leukemia isotransplant system. PMID- 4330802 TI - Transplacental blastomogenesis in organ cultures of embryonic lung tissue. PMID- 4330803 TI - [Chromosomal changes and decreased alkaline phosphatase activity induced by continuous infection of HeLa-HA2]. PMID- 4330804 TI - [Cytomegalic inclusion body disease]. PMID- 4330805 TI - Junctions between cancer cells in culture: ultrastructure and permeability. AB - Cell junctions between Novikoff hepatoma cells (N1S1-67) growing as small clumps or chains in suspension culture have been studied with ultrastructural, electrophysiological, and dye-injection techniques. Cells within clumps are commonly electrically coupled and can exchange dyes with a molecular weight of 332 to 500. Gap junctions and intermediate junctions are present, whereas true tight junctions and desmosomes are absent or very rare. This system should provide a useful model for studying the properties of "communicating" junctions. PMID- 4330806 TI - [Effectiveness of HOA formolvaccine against sheep pox]. PMID- 4330807 TI - [Distribution of alanine and aspartate transaminase activity in rat liver microstructures during development of induced hepatomas]. PMID- 4330808 TI - [Oxidative phosphorylation in the plague microbe]. PMID- 4330810 TI - Myasthenia gravis and myasthenic syndromes treated with prednisone. PMID- 4330809 TI - [Content of some metabolites and activity of a series of enzymes following abrupt cessation of insulin action]. PMID- 4330811 TI - Immunological interference with Rous sarcoma virus tumorigenesis in rats. PMID- 4330812 TI - In vivo studies of two choline acetyltransferase inhibitors. PMID- 4330813 TI - [Histoenzymological studies of the adrenal gland of the golden hamster (Mesocrisetus auratus)]. PMID- 4330814 TI - Histological and histochemical studies on the distribution of alkaline and acid phosphatases, adenosine triphosphatase, 5-nucleotidase, and non-specific esterase in the pit organs of a freshwater teleost, Saccobranchus fossilis. PMID- 4330815 TI - [Ossification state as a criterion for determination of the biological developmental state during growth]. PMID- 4330816 TI - Catalysts for the polymerization of adenosine cyclic 2',3'-phosphate on a poly (U) template. PMID- 4330817 TI - Uptake of polynucleotides by intact mammalian cells. 8. Synthetic homoribopolynucleotides. PMID- 4330818 TI - Isolation, characterization and distribution of a DNA ligase from higher plants. PMID- 4330820 TI - Inosine-coated bacteriophage T 4 . PMID- 4330819 TI - Dissociation of 5 -S RNA from 50 -S ribosomal subunits of Escherichia coli by phosphate treatment. PMID- 4330821 TI - A ribonucleic acid-iodo-proteinaceous complex from the thyroid. PMID- 4330822 TI - Respiratory regulation in Bufo arenarum eggs. PMID- 4330823 TI - Electron spin resonance investigation of osteosarcoma. PMID- 4330824 TI - Experimental models in relation to the natural history of human neoplastic disorders. PMID- 4330825 TI - [Tribulations of a virus. From Rous sarcoma in hens to cerebral tumors in dogs]. PMID- 4330826 TI - Arginase activity of mouse serum and liver tissue in some conditions of experimental liver damage. PMID- 4330827 TI - Electroencephalographic (EEG) sleep recovery following prolonged alcohol intoxication in alcoholics. PMID- 4330828 TI - Visual aftermovement effects, pupillary constriction and personality differences. PMID- 4330829 TI - Direct isolation and characterization of "flat" SV40-transformed cells. PMID- 4330830 TI - Neurohormones on brain adenyl cyclase activity in vivo. PMID- 4330831 TI - Sleep states in the newborn: influence of sound. PMID- 4330832 TI - [Continuity in different phases of psychiatric therapy. Preadmission- hospitalization--after-care. Treatment in groups and clubs]. PMID- 4330833 TI - [Sociopsychiatric evaluation of 732 after-care patients. 2. "1,000 schizophrenic after-care patients"]. PMID- 4330834 TI - Adenoid cystic carcinoma of the paranasal sinuses. PMID- 4330835 TI - Strontium induced rickets: metabolic basis. AB - Dietary strontium inhibits both the synthesis of 1,25-dihydroxycholecalciferol and intestinal calcium absorption in vitamin D(3)-repleted chicks. 1,25 Dihydroxycholecalciferol restores calcium absorption to normal, while 25 hydroxycholecalciferol is without effect in the strontium-fed chick. It is suggested that strontium induces rickets by blocking the biosynthesis of 1,25 dihydroxycholecalciferol, the metabolically active form of vitamin D in the intestine. PMID- 4330836 TI - [Comparative lectron microscopy findings on inclusions in the choroid plexus]. PMID- 4330837 TI - [Electron microscopy and experimental studies on the passage of small particulate elements through the inner wall of Schlemm's canal]. PMID- 4330838 TI - [Studies of rat mesentery]. PMID- 4330839 TI - [Occurrence of autophagic vacuoles as a result of cationic combinations]. PMID- 4330840 TI - [Histochemical studies of the enzymes of the infundibulum of the rat hypophysis]. PMID- 4330842 TI - [Malignant granular neuroma (granular cell myoblastoma). Case report and review of literature]. PMID- 4330841 TI - [Action of cycloheximide on protein metabolism of liver neoplasms induced by diethylnitrosamine]. PMID- 4330843 TI - [Sensitizing properties of purified concentrated Cl. perfringens toxoids]. PMID- 4330844 TI - [Combined adeno-staphylococcal infections in Citellus triton]. PMID- 4330845 TI - [Effect of lecithinase C of Cl. perfringens type A on blood, bone marrow and phagocytic activity of the leukocytes of guinea pigs immunized with analecithinase]. PMID- 4330847 TI - Compartmental arrangement of steroid precursors and the control of steroid hormone secretion in rat adrenal tissue in vitro. PMID- 4330846 TI - The biological activity of (1-D-serine,17-18-dilysine)- -corticotrophin-(1-18) octadecapeptide-amide. PMID- 4330848 TI - Insulinomas. PMID- 4330849 TI - Antitetanic effect of propranolo on mammalian motor-nerve and skeletal muscle, and combined action of propranolol and neostigmine on the neuro-muscular transmission. PMID- 4330850 TI - The mechanism of the push and pull principle. 8. Endocrine effects of thalidomide and its analogues. PMID- 4330851 TI - Action of diazepam on the spinal cord. PMID- 4330852 TI - The enzymic formation of myoinositol 1:2-cyclic phosphate from phosphatidylinositol. PMID- 4330853 TI - Stability and structure of binary and ternary metal ion complexes with biocytin, the sulfoxide and sulfone, N-acetyl-L-lysine, and L-alanine. PMID- 4330854 TI - A general method for the quantitative determination of saturation curves for multisubunit proteins. PMID- 4330855 TI - Positive and negative cooperativity in yeast glyceraldehyde 3-phosphate dehydrogenase. PMID- 4330856 TI - Structures and activities of oligosaccharides produced by alkaline degradation of a blood group substance lacking A, B, H, Le b specificities. PMID- 4330857 TI - Studies on phosphatidylcholine vesicles with thiocholesterol and a thiocholesterol-linked spin label incorporated in the vesicle wall. PMID- 4330858 TI - Terminal labeling of high molecular weight ribonucleic acid with dimedone. PMID- 4330859 TI - [Studies on the regulation of carbohydrate metabolism in vivo. 3. Influence of the inhibition of fatty acid oxidation]. PMID- 4330860 TI - [Comparative etiologic factors of viral hepatitis, cirrhosis and primary liver cancer]. PMID- 4330861 TI - [Epulis congenita]. PMID- 4330862 TI - Gaviscon--a floating seal? PMID- 4330863 TI - Investigations on the influence of nicotinic acid on lipolysis in isolated fat cells of rats. PMID- 4330864 TI - The effect of adenosine 3',5'-monophosphate and of N 6 -2'-O-dibutyryl-adenosine 3',5'-monophosphate on the mouse ovarian 5 -3 -hydroxysteroid dehydrogenase. PMID- 4330865 TI - A sensitive bioassay method for ACTH using isolated rat adrenal cells. PMID- 4330866 TI - Blood levels of TSH, HGH, cortisol and ACTH after synthetic thyrotropin releasing factor (TRF). PMID- 4330867 TI - Experimental hypersomatotropism: serum growth hormone and insulin, and pituitary and pancreatic changes in MtT-W15 tumor-bearing rats before and after tumor removal. PMID- 4330868 TI - Effects of cyclic AMP and epinephrine on insulin and growth hormone secretion in sheep. PMID- 4330869 TI - Effect of growth hormone on isolated rat diaphragm. Possible role of adenosine 3',5'-monophosphoric acid (cyclic AMP). PMID- 4330870 TI - Pancreatic -cell function and content of 6-phosphogluconate. PMID- 4330871 TI - Studies on the pituitary "Fettstoffwechselhormon". IV. Comparisons between the lipolytic activity of ACTH and some fractions of porcine pituitaries in vitro. PMID- 4330872 TI - Plasma-renin activity determined by a labelled antibody assay. PMID- 4330873 TI - Rat bone osteolysis in vitro: inhibitory effects of glucagon and cortisol. PMID- 4330874 TI - Evidence for an "ACTH binding factor" in plasma. PMID- 4330875 TI - The selective depression of evoked cortical EPSPs by pentobarbitone. PMID- 4330876 TI - Free fatty acids, catecholamines, and arterial hypoxia in patients with fat embolism. PMID- 4330877 TI - The continuing problem of gas gangrene: a review and report of illustrative cases. PMID- 4330878 TI - [Oat cell carcinoma and bronchial carcinoid]. PMID- 4330879 TI - Effect of calcitonin on bone resorption induced by excess vitamins A and D. PMID- 4330880 TI - The effects of ACTH, adrenalectomy and dexamethasone on the acquisition of an avoidance response in rats. PMID- 4330881 TI - Surgical treatment of mediastinal tumors. PMID- 4330882 TI - The activity of certain endometrial enzymes in cases of several years' presence of intrauterine contraceptive devices in uterine cavity. PMID- 4330884 TI - [Comparative study of the susceptibility of human diploid cell strains to cytomegalovirus (CMV)]. PMID- 4330883 TI - Adrenocortical function and sex differences in acquisition and extinction of active avoidance behavior in the rat. PMID- 4330885 TI - [Cholinergic transmission in the central nervous system]. PMID- 4330887 TI - Effect of staphylococcal -toxin on the phosphorylation of ADP by rat liver mitochondria. II. Effect of staphylococcal -toxin upon electron transport. PMID- 4330886 TI - Carbohydrate in abrin. PMID- 4330889 TI - A common biochemical change in SV40 and polyoma virus transformed mouse cells coupled to control of cell growth in culture. PMID- 4330888 TI - Structure and synthesis of a lipid-containing bacteriophage. 8. Effect of nalidixic acid on some membrane-associated activities of control and infected cells. PMID- 4330891 TI - Enzyme kinetic studies on human renin and its purified homologous substrate. PMID- 4330890 TI - Electron microscopic observations on the development of the median eminence in perinatal rats. PMID- 4330892 TI - Changes in catecholamine and angiotensin levels in the cat and dog during hemorrhage. PMID- 4330893 TI - Influence of prostaglandins on autonomic responses. PMID- 4330894 TI - Measurement of plasma renin substrate using homologous and heterologous renin. PMID- 4330895 TI - Intestinal fluid loss in hemorrhagic shock. PMID- 4330896 TI - A new pressor agent of renal origin: its differentiation from renin and angiotensin. PMID- 4330897 TI - Determinants of renal cortical volume. PMID- 4330898 TI - Conversion of angiotensin I to angiotensin II in the canine mesenteric circulation. PMID- 4330899 TI - Intracellular pathways of renal reabsorption of lysozyme. PMID- 4330900 TI - Arterial hypertension elicited by prolonged intra-vertebral infusion of angiotensin II in conscious dog. PMID- 4330901 TI - Effects of insulin and adenosine 3',5'-monophosphate on K+ flux and glucose output in perfused rat liver. PMID- 4330902 TI - Distribution and binding of insulin in the dog hindlimb. PMID- 4330903 TI - Effect of isoproterenol on water diuresis in rats with congenital diabetes insipidus. PMID- 4330904 TI - Renin in dog brain. PMID- 4330905 TI - Effects of LSD-25 and mescaline on the electroplax of the electric eel. PMID- 4330906 TI - [Biologic behavior of dusts, isolated from the lung using formamide, in the intraperitoneal test in rats]. PMID- 4330907 TI - Changes in the liver mitochondrial oxidation of succinate during cold-exposure. AB - 1. Exposure of rats to low environmental temperature resulted in increased activities of several hepatic oxidative-enzyme systems. 2. Simultaneous with increase in liver ubiquinone in cold-exposed rats, the ubiquinone-dependent succinate-neotetrazolium chloride reductase activity also increased. Such an increase could also be obtained by enriching liver with ubiquinone by feeding with an exogenous source. 3. Succinate-neotetrazolium chloride reductase activity could be increased by preincubation of mitochondria with succinate and the mechanism of this activation appears to be different from that obtained on addition of ubiquinone. 4. Succinate-neotetrazolium chloride reductase activity was found to be more labile than succinate dehydrogenase on freezing and thawing and storage, and the presence of succinate gave protection against this loss in hepatic mitochondria obtained from both normal and cold-exposed animals. PMID- 4330908 TI - Heterogeneity of protein-polysaccharides of porcine articular cartilage. The chondroitin sulphate proteins associaterd with collagen. AB - Pig articular cartilage, from which protein-polysaccharides soluble in iso osmotic sodium acetate had been removed, was extracted in three further stages with 8m-urea in 2m-sodium acetate and with tris-HCl buffer after bacterial collagenase digestion, followed by the same urea-sodium acetate solution, thus leaving only 2% of the original uronic acid in the tissue. The histological appearance of the cartilage was unaltered until after collagenase digestion. The collagenase used did not affect the viscosity or molecular size of a protein polysaccharide preparation obtained previously. The protein-polysaccharides in each extract differed in size, amino acid composition and protein content, but protein and keratan sulphate contents were not related to hydrodynamic size, in contrast with protein-polysaccharides extracted previously before collagenase digestion. Hydroxyproline could not be removed from those obtained by the first urea-sodium acetate extraction until degraded by heat. The galactosamine/pentose molar ratio agreed closely with the galactosamine/serine molar ratio that was destroyed on treatment with 0.5m-sodium hydroxide, showing that chondroitin sulphate was attached only to serine residues. From these molar ratios the chondroitin sulphate chains were calculated to be of the same average length in protein-polysaccharides in all three extracts although somewhat shorter than in protein-polysaccharides extracted previously. Some threonine residues were also destroyed on alkali treatment suggesting that keratan sulphate may be attached to threonine. These findings together with previous results show that differences in size, composition and physical state extend to all the protein-polysaccharides in cartilage. PMID- 4330909 TI - Prognostic implications of electroencephalographic findings of hypsarrhythmia in first year of life. AB - One hundred and five children who had shown the electroencephalographic (E.E.G.) features of hypsarrhythmia in the first year of life (1956-62) were assessed in 1969 in respect of death and mental development. Irrespective of the presenting symptomatology, and to some extent irrespective of therapy, mortality in the group was of the order of one in four (mostly before the age of 3 years) and the incidence of mental subnormality in the survivors was 77%. Only 18 children attained fairly normal standards of mental development and could attend ordinary schools. It seems that whatever the clinical picture at the time, the presence of hypsarrhythmia in the E.E.G. of an infant is a physical sign of grave prognostic implications. PMID- 4330910 TI - Australia antigen and hepatitis in Accra, Ghana. AB - Viral hepatitis in young adults in Accra, Ghana, is associated with Australia antigen (H.A.A.). Sera from 85 patients in hospital with viral hepatitis were available for determinations of H.A.A. Of the 16 patients whose serum was obtained within the first week of symptoms, 15 were positive. The only factor related to finding H.A.A. was the time between onset of symptoms and the collection of the serum sample. Persistence of H.A.A. was associated with persistence of jaundice in men but not in women. Previous epidemiological studies in Accra found no evidence for parenteral transmission of viral hepatitis and showed a shanty-town predilection pointing to faecal-oral transmission. It thus seems that H.A.A.-associated hepatitis is transmitted in West Africa either faecal-orally or by shanty-town associated arthropods. The finding that H.A.A. hepatitis is the usual hepatitis in young adults in Accra is in accord with the high prevalence of H.A.A. elsewhere in the general population in Africa and may be related to the high rate of cirrhosis and hepatoma in Africa. PMID- 4330911 TI - Treatment of Bell's palsy. PMID- 4330912 TI - [Comparative studies on the enzymatic hydrolysis of p-nitrophenyl-phosphate and adenosine-5-triphosphate by 3 fractions of the rat brain]. PMID- 4330913 TI - Adenosine deaminase activity in virus-induced murine leukemia. PMID- 4330914 TI - Ultrastructural and biochemical studies on ribonucleoprotein particles from isolated nucleoli of thioacetamide-treated rat liver. PMID- 4330915 TI - Leakage as the source of overgrowth stimulating activity in Rous sarcoma transformed cultures. PMID- 4330916 TI - Effects of enforced milk stasis on mammary gland epithelium, with special reference to changes in lysosomes and lysosomal enzymes. PMID- 4330917 TI - Synergistic effect of polymixin B with other antibiotics on the transformation of Naegleria gruberi. PMID- 4330918 TI - Studies on transport of macromolecules and small particles across mesothelial cells of the mouse omentum. I. Morphologic aspects. PMID- 4330920 TI - [Potential antiviral agents. XV. Acyl derivatives of pyrimidines and pruines]. PMID- 4330919 TI - Differentiation of neurons and myocytes in cell cultures made from Drosophila gastrulae. PMID- 4330921 TI - Some quantitative histochemical studies of the periodic acid oxidation of glycogen in situ. PMID- 4330923 TI - Some properties of the naphthalene oxygenase from Pseudomonas sp. NCIB 9816. PMID- 4330922 TI - Mechanisms of active transport in isolated membrane vesicles. I. The site of energy coupling between D-lactic dehydrogenase and beta-galactoside transport in Escherichia coli membrane vesicles. PMID- 4330924 TI - Differential distribution of orthophosphate- 32 P and glycerol- 14 C among molecular species of phosphatidylinositols of rat liver in vivo. AB - The incorporation of orthophosphate-(32)P and glycerol-2-(14)C into the various species of rat liver phosphatidylinositols as a function of time was determined in vivo. (32)P was administered intraperitoneally and glycerol-(14)C was given intravenously. The phosphatidylinositols were resolved intact according to degree of unsaturation. 1-3 hr after injection of the labeled phosphate, the relative specific activity of the linoleoyl dienes exceeded that of the arachidonoyl tetraenes about 17-fold, and that of the trienes and polyenes about 8-fold. The relative specific activities of all the fractions became about equal 2-3 days after administration of (32)P. The labeling patterns obtained with glycerol were comparable to those seen for the phosphate. As early as 5 min about 65% of the activity was localized in the monoenes plus dienes, while only 17% was found in the tetraenes, although the mass proportions of these fractions were 7.1 and 77.0% of the total phosphatidylinositols, respectively. The recovery of the total radioactivity in the monoenes and dienes decreased continuously with time to about 15% at 9 hr, while that recovered in the tetraenes rose steadily to about 70%. The present data are consistent with an active synthesis of the monoenoic and dienoic phosphatidylinositols by way of the phosphatidate, followed by a deacylation-reacylation cycle involving arachidonic acid, as claimed for other rat liver glycerophosphatides. PMID- 4330925 TI - Choline metabolism and membrane formation in rat hepatoma cells grown in suspension culture. 3. Choline transport and uptake by simple diffusion and lack of direct exchange with phosphatidylcholine. AB - The initial rate of incorporation of methyl-labeled choline into the acid-soluble pool (phosphorylcholine) of Novikoff hepatoma cells growing in suspension culture was investigated as a function of the choline concentration in the medium. Below, but not above, 20 micro m, choline incorporation followed simple Michaelis-Menten kinetics at 24, 33, or 37 degrees C with an apparent K(m) of 4-7 micro m, and the V(max) values decreased with a Q(10) of about 2.3 with a decrease in temperature. Between 20 and 500 micro m, on the other hand, the rate of incorporation increased linearly with an increase in choline concentration in the medium, and the increase in incorporation rate with increase in choline concentration was about the same at all temperatures tested. The data suggest that at low concentrations choline is taken up mainly by a transport reaction, whereas at concentrations above 20 micro m, simple diffusion becomes the principal mode of uptake. The energy of activation for choline transport was estimated from an Arrhenius plot of the V(max) values as 67,000 J (16 kcal)/mole. At concentrations below 20 micro m, choline incorporation into membrane phosphatidylcholine also followed simple Michaelis-Menten kinetics, and the apparent K(m) was about the same as that for choline transport. The data support the conclusion that the transport of choline into the cell is the rate-limiting step in the conversion of choline to phosphorylcholine and its incorporation into phosphatidylcholine. At concentrations above 100 micro m, on the other hand, the ultimate rate of choline incorporation into phosphatidylcholine was independent of the choline concentration in the medium or the intracellular level of phosphorylcholine. Further, the rate of turnover of the choline moiety of phosphatidylcholine (half life, 20-24 hr) either in whole cells or during incubation of isolated membrane fractions was unaffected by the presence of an excess of choline in the medium. The overall results indicate that a direct exchange between free choline and the choline moiety of phosphatidylcholine does not play a significant role in the incorporation of choline into phosphatidylcholine by Novikoff cells or in the turnover of the choline moiety of phosphatidylcholine, and that labeled choline therefore is a useful precursor in studying the synthesis and turnover of membrane phosphatidylcholine in these cells. PMID- 4330926 TI - Inhibition of lipid synthesis in isolated rat hepatocytes by serum lipoproteins. AB - The incorporation of labeled acetate into lipids was studied in rat hepatocytes isolated after treatment of liver with collagenase and hyaluronidase. About 60% of the lipid radioactivity was in free cholesterol and 13% was in triglycerides. Acetate incorporation was markedly inhibited when human serum lipoproteins were present in the incubation medium. Very low, high, and low density lipoproteins, at concentrations of 1.0 mg/ml, inhibited acetate incorporation by 70, 55, and 35%, respectively. Chylomicrons, at similar concentrations, did not inhibit acetate incorporation. The distribution of radioactivity into lipid classes was unchanged by the addition of lipoproteins. Lipoproteins did not produce a nonspecific toxic effect on hepatocytes, since their addition did not alter the rate of leucine incorporation into protein. The addition of the delipidated protein from low density lipoprotein or of lecithin in amounts comparable to those present in inhibitory concentrations of lipoproteins failed to diminish acetate incorporation. Artificial cholesterol-lecithin emulsions containing small amounts of free cholesterol did not inhibit lipid synthesis. Although the mechanism for the inhibition of acetate incorporation by lipoproteins is unclear, such effects may play some physiological role in the control of lipid biosynthesis in the liver. PMID- 4330927 TI - Determination of regional distribution of adenosine 3',5'-monophosphate in rat brain. PMID- 4330928 TI - 5'-amido analogs of adenosine 3',5'-cyclic monophosphate. PMID- 4330929 TI - Effects on body temperature of prostaglandins of the A, E and F series on injection into the third ventricle of unanaesthetized cats and rabbits. AB - 1. Prostaglandins were injected into the third ventricle of unanaesthetized cats and rabbits whilst rectal temperature was recorded.2. In cats prostaglandin E(1) and E(2) (PGE(1) and PGE(2)) produced hyperthermia which mostly began within a minute of injection and lasted 1 or more hours. With PGE(1) the hyperthermia was shown to be dose dependent between 10 ng and 10 mug (2.8 x 10(-11) and 2.8 x 10( 8)M). The hyperthermia was associated with vigorous shivering, skin vasoconstriction and piloerection. In several experiments a secondary rise in temperature occurred a few hours after the injection but such an effect was sometimes observed with control injections of 0.9% NaCl solution as well.3. None of the other prostaglandins (A(1), F(1alpha), F(2alpha)) examined in cats had an immediate or strong effect on temperature comparable to the hyperthermia produced by PGE(1) and PGE(2).4. In rabbits PGE(1) (2 mug) also caused hyperthermia which began shortly after the injection and lasted for hours. PGF(2alpha) and PGA(1), did not affect temperature.5. In cats it was seen that an intraperitoneal injection of 4-acetamidophenol (paracetamol 50 mg/kg) did not affect the initial strong hyperthermia produced by PGE(1) and PGE(2) but abolished the secondary rise.6. The possibility is discussed that PGE(1) plays a role as a central transmitter or modulator in temperature regulation. PMID- 4330930 TI - Selective effects of an octopus toxin on action potentials. AB - 1. A lethal, water soluble toxin (Maculotoxin, MTX) with a molecular weight less than 540, can be extracted from the salivary glands of an octopus (Hapalochlaena maculosa).2. MTX blocks action potentials in sartorius muscle fibres of toads without affecting the membrane potential. Delayed rectification is not inhibited by the toxin.3. At low concentrations (10(-6)-10(-5) g/ml.) MTX blocks action potentials only after a certain number have been elicited. The number of action potentials, which can be defined accurately, depends on the concentration of MTX and the concentration of sodium ions in the extracellular solution.4. The toxin has no post-synaptic effect at the neuromuscular junction and it is concluded that it blocks neuromuscular transmission by inhibiting action potentials in motor nerve terminals. PMID- 4330931 TI - Effect of norgestrel in combination with ethinyl oestradiol on the human pituitary-adrenal axis. PMID- 4330932 TI - [Clinical application of glucagon]. PMID- 4330933 TI - [Clinical and histological experiences in 54 malignant parotid tumors]. PMID- 4330934 TI - Succinic-dehydrogenase and cytochrome-oxidase activity in the hypothalamus during the sexual cycle in rats. PMID- 4330935 TI - Verbal and motor memory in the amnestic syndrome. PMID- 4330936 TI - [Islet cell tumors: a diarrheogenic syndrome]. PMID- 4330937 TI - Glial cell function: uptake of transmitter substances. AB - Rabbit-brain fractions enriched in neuronal cell bodies and in glial cells accumulated norepinephrine, serotonin, dopamine, and gamma-aminobutyric acid, substances believed to serve as neurotransmitters in the central nervous system. Both neurons and glia were able to concentrate the monoamine transmitters about 4 fold from a medium containing 0.1-1 muM concentrations. However, the glial-cell fraction concentrated aminobutyrate over a 100-fold from the medium, in contrast to the neuronal fraction, which concentrated this amino acid only 4-fold. The uptake of aminobutyrate by glial cells was 30-50% of that of synaptosome preparations. Its uptake in all fractions was temperature sensitive, sensitive to metabolic inhibitors, and exhibited K(m) values of 0.72 muM for the neuronal fraction, 0.42 muM for the synaptosomal fraction, and 0.27 muM for the glial-cell fraction. These results are interpreted as evidence that the glial cell is involved in limiting the extracellular build-up of substances that might trigger synaptic transmission by removing any transmitters that may diffuse out of the synaptic cleft during the transmission of impulses. The possible function of the enormous ability of glia and synaptosomes to accumulate aminobutyrate is discussed in light of the actions and distribution of this substance in the central nervous system. PMID- 4330938 TI - Temperature-dependent alterations in sugar transport in cells infected by a temperature-sensitive mutant of Rous sarcoma virus. AB - Cells transformed by Rous sarcoma virus take up 2-deoxyglucose at a faster rate than uninfected cells, under conditions where transformed and nontransformed cells grow at the same rate. In cells infected by a temperature-sensitive mutant, the stimulation of 2-deoxyglucose uptake is temperature dependent: the increase is observed at the permissive (36 degrees C), but not at the nonpermissive (41.5 degrees ) temperature. When infected cells are shifted from the nonpermissive temperature to the premissive temperature, the uptake of 2-deoxyglucose increases from a rate equal to that of uninfected cells to a rate equal to that of cells infected by the wild-type Schmidt-Ruppin Rous sarcoma virus. The reverse change occurs when the infected cells are shifted from the permissive to the nonpermissive temperature. By the use of cytosine arabinoside, an inhibitor of DNA synthesis, it was possible to show that DNA synthesis is neither required for the transformation, which occurs when the infected cells are shifted from the nonpermissive to the permissive temperature, nor for the phenotypic reversion, which occurs in the reverse shift. PMID- 4330939 TI - A specific metabolic activity on the surface membrane in malignant cell transformation. AB - The carbohydrate-binding protein, Concanavalin A (Con A), binds to glucose- or mannose-like sites on the cell-surface membrane. Unless the cells are treated with trypsin, this protein agglutinates malignantly transformed cells, but not normal cells. The transformed cells were agglutinated at 24 degrees C but not at 4 degrees C. Transformed and normal cells treated with trypsin were agglutinated at both 24 degrees C and 4 degrees C with high concentrations of Con A (500 mug/ml), but only at 24 degrees C with low concentrations (5 mug/ml). The same number of Con A molecules were bound to normal and transformed cells at both temperatures. The results indicate that the site for Con A on the surface membrane contains two activities, a component that binds Con A molecules (B) and a component that determines agglutination (A). B is not temperature sensitive and is active in normal and transformed cells, whereas A, which is temperature sensitive, is in an active form only in transformed cells. A can be activated by trypsin, and the increased activity per cell allows agglutination at 4 degrees C with a high, but not with a low, concentration of Con A. Agglutination of transformed cells by wheat-germ agglutinin, which binds to N-acetyl-D-glucosamine like sites, and by soybean agglutinin, which binds to N-acetyl-D-galactosamine like sites, was not temperature sensitive. Thus, the temperature-sensitive component A is specific for Con A, and malignant transformation of normal cells, which results in agglutinability by Con A, is associated with the activation of a specific temperature-sensitive activity on the surface membrane. PMID- 4330940 TI - Regulation of adenosine 3':5'-cyclic monophosphate concentration in cultured human astrocytoma cells by catecholamines and histamine. AB - Norepinephrine, epinephrine, and histamine cause a rapid increase in the concentration of adenosine 3':5'-cyclic monophosphate (cAMP) in a tumor astrocyte cell line derived from a primary culture of a human glioblastoma multiforme. The catecholamine-induced increase in cAMP is dependent on the cell density, being far greater in cells in the log phase of growth than in cells near terminal density. The response to norepinephrine is inhibited 50% by 0.01 muM propranolol, a blocking agent of beta-adrenergic receptors. In contrast, the effect of histamine on cAMP concentration varies only slightly from log-phase growth to terminal density, and is not inhibited by 10 muM propranolol. The results suggest that astrocytoma cells have independent receptors for catecholamines and histamine. Further, if the astrocytoma cell is an adequate model of the normal glial cell, these results suggest that astrocytes in human cerebral cortex may be sensitive to norepinephrine and histamine. PMID- 4330941 TI - A cyclic AMP-dependent protein kinase of the bovine pineal gland. AB - A protein kinase that is dependent on cAMP was found to be present in significant amounts in rat and bovine pineal glands. This enzyme system was isolated from bovine pineal glands and shown to consist of two proteins, a kinase and a cAMP binding protein. The kinase primarily phosphorylates histones and may function in the control of the diurnal variation of the enzymes in the melatonin biosynthetic pathway. PMID- 4330943 TI - Inactivation of D-alanine carboxypeptidase by penicillins and cephalosporins is not lethal in Bacillus subtilis. AB - The D-alanine carboxypeptidase of Bacillus subtilis is a particulate enzyme that is irreversibly inactivated by penicillins and cephalosporins. However, the lethal concentrations of these antibiotics are not the same as those that inhibit enzymatic activity in vitro. 6-Aminopenicillanic acid inactivates at least 95% of the enzyme at nonlethal concentrations. Conversely, cephalothin is lethal at concentrations that do not inactivate the enzyme. Experiments with intact, growing cells confirm the results obtained in vitro. Therefore, a killing site distinct from the carboxypeptidase must be postulated. PMID- 4330942 TI - Glucose and the metabolism of adenosine 3':5'-cyclic monophosphate in Escherichia coli. AB - Measurements of adenosine 3':5'-cyclic monophosphate (cAMP) concentrations have been made in Escherichia coli under various conditions. Different strains of E. coli accumulate different extracellular concentrations of cAMP (0.2-4 mum) at stationary phase. Mutation at the RNA control locus does not affect the accumulation pattern. Growth of the bacteria in minimalsalts medium leads to a greater accumulation of cAMP than growth in nutrient broth. Partition studies show that essentially all of the cAMP that is accumulated is found in the medium rather than in the cells. Kinetic studies show that most of the cAMP is formed coincidentally with exhaustion of glucose from the medium. Growth on high concentrations of glucose leads to inhibition of cAMP formation. Other carbon sources cannot substitute for glucose in this inhibitory effect. Measurements of enzyme activities indicate that glucose suppression of cAMP formation cannot be accounted for by a decreased activity of adenylate cyclase or an increased activity of cAMP phosphodiesterase (EC 3.1.3.7). PMID- 4330944 TI - Dibutyryl adenosine cyclic 3':5'-monophosphate effects on goldfish behavior and brain RNA metabolism. AB - Intraventricular administration of dibutyryl adenosine cyclic 3':5'-monophosphate into goldfish brains produced hyperactive animals. A study of the effects of the drug (25-50 mg/kg) on the incorporation of [5-(3)H] orotic acid, as a precursor of labeled uridine and cytidine, into newly synthesized RNA showed the formation of an RNA with a uridine to cytidine ratio 20-50% higher than that of the control. In double-labeling experiments with uridine as the labeled precursor, the synthesis of a nuclear RNA fraction (not produced in the absence of drug) was demonstrated. Some of this RNA was found to migrate into the cytoplasmic fraction and to become associated with polysomes. The results suggest that cyclic AMP might function as a "metabolic demand signal" for eliciting new RNA synthesis in goldfish brain. PMID- 4330945 TI - Synthesis of DNA complements of natural RNAs: a general approach. AB - The availability of a purified RNA-instructed DNA polymerase (reverse transcriptase) from avain myeloblastosis virus provided the opportunity to explore whether this enzyme could be used as a general tool for synthesizing DNA complements of a wide variety of natural RNAs. The results described show that this potentially useful situation is in fact realized. The avian viral transcriptase can mediate the synthesis of DNA complementary to RNAs of such widely divergent origins as Qbeta bacteriophage and Moloney sarcoma virus. These findings open up novel pathways for the experimental resolution of several interesting problems. Thus, given a purified RNA message, one should be able to synthesize the corresponding DNA genetic material. If suitably labeled, the synthetic DNA has various obvious uses, including its use via molecular hybridization as an analytical probe for the corresponding gene on the chromosomes or for its message in a complex mixture of RNA molecules. Of immediate practical interest is the import of these findings for viral oncology. They imply that for many purposes we will not be compelled to isolate or use the "reverse transcriptase" from each oncogenic virus in order to synthesize its complementary DNA. The ability of one enzyme to accept a variety of oncogenic RNAs will obviate many of the logistical difficulties that arise, particularly in attempts to illuminate the etiology of human cancer. PMID- 4330946 TI - Determination of the gene sequence of poliovirus with pactamycin. AB - By examination of the virus-specific polypeptides formed after the addition of pactamycin, an inhibitor of protein chain initiation, to infected cells, it has been possible to tentatively locate the virus coat proteins at the amino terminus of the large, virus-specific protein precursor, and, therefore, to assign the coat protein cistron to the 5' end of the RNA. PMID- 4330947 TI - [Diagnosis of renal leukemia in the excretory urogramm]. PMID- 4330948 TI - [Antibiotics in pediatrics]. PMID- 4330949 TI - [The influence of oestrogens on the permeability of the vascular wall]. PMID- 4330950 TI - [Enzyme therapy of neoplasms]. PMID- 4330951 TI - Hereditary eliptocytosis associates with beta-thalassaemia and a variant of Rh (D). A study in a Sinhalese family. PMID- 4330952 TI - An ultrastructural study of synthesis and release of beta granules in the human pancreas. PMID- 4330953 TI - An autopsy case of Laurence-Moon-Biedl syndrome with pituitary eosinophilic adenoma. PMID- 4330954 TI - [Receptors of the human retina]. PMID- 4330955 TI - Suggested prophylaxis for ovarian cancer. A 20 year report from cases at Butterworth Hospital. PMID- 4330956 TI - An investigation of the gestational increase in serum hexosaminidase B. PMID- 4330957 TI - Growth and stimulation of mouse trophoblastic cells in culture by polyoma virus. PMID- 4330958 TI - The recognition of chronic hypopituitarism resulting from postpartum pituitary necrosis. PMID- 4330959 TI - [Competition of renal effects of angiotensin II and extracellular fluid volume receptors]. PMID- 4330960 TI - The role of adenosine 3':5'-cyclic monophosphate in the regulation of insulin release by isolated rat islets of Langerhans. AB - 1. Concentrations of cyclic AMP (adenosine 3':5'-cyclic monophosphate) and rates of insulin release were measured in islets of Langerhans isolated from rat pancreas and incubated for various times in the presence of glucose, 3-isobutyl-1 methylxanthine, caffeine, theophylline, adrenaline and diazoxide. 2. Caffeine and theophylline produced small but significant increases in both cyclic AMP and release of insulin when they were incubated in the presence of 10mm-glucose. 3. 3 Isobutyl-1-methylxanthine produced a marked increase in the intracellular concentration of cyclic AMP in the presence of 5mm- and 10mm-glucose. However, insulin release was stimulated only in the presence of 10mm-glucose. 4. In response to rising concentrations of extracellular glucose (5-20mm) there was no detectable increase in the intracellular concentration of cyclic AMP even though there was a marked increase in the rate of insulin release. 5. In response to 10mm-glucose insulin release occurred in two phases and 3-isobutyl-1 methylxanthine potentiated the effect of glucose on both phases. The intracellular concentration of cyclic AMP remained constant with glucose and rose within 10min to its maximum value with 3-isobutyl-1-methylxanthine. 6. Adrenaline and diazoxide inhibited insulin release and lowered the intracellular concentration of cyclic AMP when islets were incubated with glucose or 3-isobutyl 1-methylxanthine. 7. It is suggested that glucose does not stimulate insulin release by increasing the concentration of cyclic AMP in islet cells. However, the concentration of cyclic AMP in islet cells may modulate the effect of glucose on the release process. PMID- 4330961 TI - The effect of adrenaline and of alpha- and beta- adrenergic blocking agents on 32P incorporation into fat-cell phospholipids. PMID- 4330962 TI - The oxidation of exogenous reduced nicotinamide-adenine dinucleotide by plant mitochondria. PMID- 4330963 TI - Kinetics and inhibition by adenosine phosphates and nitrite of nitrate reductase from Spinacea oleracea L. PMID- 4330964 TI - Gentisic acid and its 3- and 4-methyl-substituted homologoues as intermediates in the bacterial degradation of m-cresol, 3,5-xylenol and 2,5-xylenol. AB - 1. Intact cells of a non-fluorescent Pseudomonas grown with m-cresol, 2,5 xylenol, 3,5-xylenol, 3-ethyl-5-methylphenol or 2,3,5-trimethylphenol rapidly oxidized all these phenols to completion. 3-Hydroxybenzoate and 2,5 dihydroxybenzoate (gentisate) were also readily oxidized. 2. 3-Hydroxybenzoic acid and 2,5-dihydroxybenzoic acid were isolated as products of m-cresol oxidation by cells inhibited by alphaalpha'-bipyridyl. Alkyl-substituted 3 hydroxybenzoic acids and alkyl-substituted gentisic acids were formed similarly from 2,5-xylenol, 3,5-xylenol, 3-ethyl-5-methylphenol and 2,3,5-trimethylphenol. 3. When supplemented with NADH, not NADPH, extracts of cells grown with 2,5 xylenol catalysed the oxidation of all five phenols and accumulated the corresponding gentisic acids in the presence of alphaalpha'-bipyridyl. 4. Cells of a fluorescent Pseudomonas grown with m-cresol oxidized m-cresol, 3,5-xylenol and 3-ethyl-5-methylphenol to completion and oxidized 2,5-xylenol and 2,3,5 trimethylphenol partially. The oxidation product of 2,5-xylenol was identified as 3-hydroxy-4-methylbenzoic acid. In the presence of alphaalpha'-bipyridyl, 3 hydroxy-5-methylbenzoic acid and 3-methylgentisic acid were formed from 3,5 xylenol. PMID- 4330966 TI - Insulin, amino acid metabolism and lipolysis in isolated fat-cells. PMID- 4330965 TI - Metabolic studies on retinoic acid in the rat. AB - The nature of metabolites in the urine arising from differentially labelled retinoic acid was investigated after injection of physiological doses into retinol-deficient rats. Distribution of radioactivity after partition of urine into ether-soluble, acidic and water-soluble fractions revealed that there were at least six metabolites in urine. Of these, the major metabolite(s) was one lacking both C-14 and C-15 of retinoic acid. Enzymic or alkaline hydrolysis of acidic and water-soluble fractions did not release any retinoic acid, thus indicating that retinoyl beta-glucuronide was not present in urine in significant amounts. PMID- 4330967 TI - Regulation of plasma triglyceride utilization. PMID- 4330968 TI - Reactions of D-glyceraldehyde 3-phosphate dehydrogenase facilitated by oxidized nicotinamide-adenine dinucleotide. AB - Transient kinetic methods have been used to study the influence of NAD(+) on the rate of elementary processes of the reversible oxidative phosphorylation of d glyceraldehyde 3-phosphate catalysed by d-glyceraldehyde 3-phosphate dehydrogenase. In the pH range 5-8 NAD(+) is bound to the enzyme during the following elementary processes of the mechanism: phosphorolysis of the acyl enzyme, its formation from 1,3-diphosphoglycerate and the enzyme and the formation and breakdown of the glyceraldehyde 3-phosphate-enzyme complex. The rates of these four elementary processes only equal or exceed the turnover rate of the enzyme when NAD(+) is bound and are as much as 10(4) times the rates in the absence of NAD(+). Autocatalysis of the reductive dephosphorylation of 1,3 diphosphoglycerate occurs when glyceraldehyde 3-phosphate release is rate determining because NAD(+) is a reaction product. An important feature of the enzyme mechanism is that the negative-free-energy change of a chemical reaction, acyl-enzyme formation, is linked in a simple way to the positive-free-energy change of a dissociation reaction, NAD(+) release. PMID- 4330969 TI - Iliacus compartment compression syndrome. PMID- 4330970 TI - Effects of stimulation and hemicholinium (HC-3) on the fine structure of nerve endings in the superior cervical ganglion of the cat. PMID- 4330971 TI - The ontogenetic development of synaptic junctions, synaptic activation and responsiveness to neurotransmitter substances in rat cerebellar purkinje cells. PMID- 4330972 TI - [Multiplication and transmission of the vesicular stomatitis virus by Aedes aegypti (L.)]. PMID- 4330973 TI - [Isolation of the virus in the respiratory syndrome of horses]. PMID- 4330974 TI - [1st experiments concerning the vaccination of horses against rhino-pneumonia (viral abortion of mares) with a live vaccine from cell cultures]. PMID- 4330975 TI - [Influenza and rhino-pneumonia in horses in France]. PMID- 4330976 TI - A note on the subtypes of vesicular stomatitis, type Indiana. PMID- 4330977 TI - An outbreak of mare abortion in Japan due to infection with equine rhinopneumonitis virus. PMID- 4330978 TI - [The sanitary situation and preventive methods used in Ivory Coast]. PMID- 4330979 TI - The epidemiology of vesicular stomatitis in the United States. PMID- 4330980 TI - Japanese encephalitis in domestic animals. PMID- 4330981 TI - [Virological and epidemiological aspects of vesicular stomatitis. 1. Current situation in Venezuela]. PMID- 4330982 TI - Experiment on the fowl pox vaccine for prevention of the mucosal type of fowl pox. PMID- 4330983 TI - Effects of sex hormones on the renal pressor system. PMID- 4330984 TI - Correlation between the electrical activity and acetylcholine release from the cerebral cortex and medulla during hypercapnia. PMID- 4330985 TI - Effect of dietary calcium, phosphorus, and vitamin D 3 on alkaline phosphatase activity of intestinal mucosa of chicks. PMID- 4330987 TI - [Conformational transitions and oxidation-reduction potential of cytochrome P 450]. PMID- 4330986 TI - Biphasic response of the transmurally stimulated rat duodenum. PMID- 4330988 TI - [Analysis of unconditioned pain stimulation at the level of somatosensory cortical neurons]. PMID- 4330989 TI - [Intermidiary metabolism of sorbitol, xylitol and cyclamates]. PMID- 4330990 TI - Enhancement of axonal regeneration in the brain of the rat by corticotrophin and triiodothyronine. PMID- 4330991 TI - Role of water structure in cell-wall interactions. PMID- 4330992 TI - Specific immunosuppression, polyinosinic--polycytidylic acid, and viruses in New Zealand mice. PMID- 4330994 TI - [Immunopathy and virus persistence in the pathogenesis of recurrent aphthous stomatitis]. PMID- 4330993 TI - Immunosuppression and oncogenic virus infections. PMID- 4330995 TI - Recent progress in ovarian cancer. PMID- 4330996 TI - Tumors of the peripheral nervous system. PMID- 4330997 TI - Immunization with live types 7 and 4 adenovirus vaccines. I. Safety, infectivity, antigenicity, and potency of adenovirus type 7 vaccine in humans. PMID- 4330998 TI - Immunization with live types 7 and 4 adenovirus vaccines. II. Antibody response and protective effect against acute respiratory disease due to adenovirus type 7. PMID- 4330999 TI - A possible pathogenic role for virus-carrier lymphocytes. PMID- 4331000 TI - Flexner and Noguchi's globoid red herrings: a footnote to the history of poliomyelitis. PMID- 4331002 TI - An ultrastructural study of the development of a surface-lining system in the avian lung. PMID- 4331001 TI - The role of the foetal pituitary in the susceptibility of the foetus to adrenal necrosis induced by 7-hydroxymethyl-12-methylbenz(a)anthracene. PMID- 4331003 TI - Viability of the rat blastocyst following the oral administration of potassium perchlorate or potassium iodide to the mother. PMID- 4331004 TI - On the characterization of ovine pituitary gonadotrophins. PMID- 4331005 TI - Action of cyclic AMP in vitro on the uptake and incorporation of radioactive precursors into RNA and proteins in rat uterus. PMID- 4331006 TI - Effect of daily single-dose corticoid therapy on the pituitary-ovarian axis: a preliminary report. PMID- 4331007 TI - [Electrophysiological findings during treatment of the parkinsonian syndrome with amantadine]. PMID- 4331008 TI - Viruses and human cancer. PMID- 4331010 TI - Alteration of the homograft response as a determinant of carcinogenicity. PMID- 4331012 TI - Urinary excretion of perchlorosoluble proteins in various renal diseases. PMID- 4331011 TI - Chemistry of pesticides. PMID- 4331013 TI - Indirect haemagglutination of human cytomegalovirus. PMID- 4331014 TI - Papova virus-like particles in focal epithelial hyperplasia. PMID- 4331015 TI - [The treatment of patients with Melkerson-Rosenthal syndrome]. PMID- 4331016 TI - Pathophysiology of hyperuricemia in primary gout. PMID- 4331017 TI - [Quantitative evaluation of the purity of subcellular structure preparations]. PMID- 4331018 TI - [Shock in animal experiments: some problems in the regulation of pulmonary and systemic circulation]. PMID- 4331019 TI - [Course and treatment of herpervirus hominis infections. II. Therapy]. PMID- 4331020 TI - Clinicopathologic studies in feminizing tumors of the ovary. 3. The role of genital cytology. PMID- 4331021 TI - Exfoliative cytology of primary and metastatic Wilms tumors. PMID- 4331022 TI - Preparation of cytologic smears from solid tumors. PMID- 4331024 TI - The evaluation of sex chromatin as a prognostic factor in carcinoma of the breast. A preliminary report. PMID- 4331023 TI - Light and electron microscopic observations on malignant cells in cerebrospinal fluid from metastatic alveolar cell carcinoma. PMID- 4331025 TI - Exfoliative cytology of the urinary bladder irrigation specimen. PMID- 4331026 TI - Cytologic differentiation of carcinoma of the breast by electron microscopy. PMID- 4331027 TI - Complement-fixation antibodies to adenovirus-associated viruses, cytomegaloviruses and herpes simplex viruses in patients with tumors and in control individuals. PMID- 4331028 TI - Non-neoplastic sclerotic pulmonary lesion (sclerosing hemangioma). Report of a case. PMID- 4331029 TI - [Mycotoxins and their public health imbrications]. PMID- 4331030 TI - Enzyme electrophoresis on cellulose acetate gel: zymogram patterns in mgh-mouse and man--Chinese hamster somatic cell hybrids. PMID- 4331031 TI - Methyrapone interaction with Pseudomonas putida cytochrome P-405. PMID- 4331032 TI - Phosvitin, a phosphoglycoprotein: composition and partial structure of carbohydrate moiety. PMID- 4331033 TI - [Myothelia and breast cancer]. PMID- 4331034 TI - [Malignant tumors in otorhinolaryngology. II. Tumors of the nose and its sinuses. 2. Treatment methods, results, problems of after care and rehabilitation]. PMID- 4331035 TI - [Polygraphic recordings of night sleep in patients with brain stem lesions]. PMID- 4331036 TI - Evidence for another factor in the regulation of corticosterone biosynthesis by ACTH. PMID- 4331038 TI - Preparation of three vertebrate collagenases in pure form. PMID- 4331037 TI - Relationship of adenosine-3', 5'-monophosphate to other adenine nucleotides in human platelets. PMID- 4331039 TI - The conformation of myosin during the steady state of ATP hydrolysis: studies with myosin spin labeled at the S 1 thiol groups. PMID- 4331040 TI - Steroidogenesis in isolated adrenal cells of rat. II. Effect of caffeine on ACTH and cyclic nucleotide-induced steroidogenesis and its relation to cyclic nucleotide phosphodiesterase (PDE). PMID- 4331041 TI - Crystalline L-leucine dehydrogenase. PMID- 4331042 TI - Synthesis of polyoma DNA by isolated nuclei. PMID- 4331043 TI - 5S RNA 3 , a new nucleus-specific 5S RNA. PMID- 4331044 TI - A succinate- and DPNH-reducible o-type cytochrome in mitochondrial preparations from Tetrahymena pyriformis. PMID- 4331045 TI - Spectroscopic evidence for beta structure in rat adipocyte plasma membrane protein. PMID- 4331047 TI - [Lipid linkages in endoplasmic reticulum and mitochondrial membranes]. PMID- 4331046 TI - Studies on the partial reactions catalyzed by the (Na++K+)-activated ATPase. 3. Relation of K+-dependent p-nitrophenylphosphatase to Na+ transport in red cell ghosts. PMID- 4331048 TI - Architecture of the poliovirus replicative intermediate RNA. PMID- 4331049 TI - [Bacterial L-glutamate decarboxylases: their action on L homocysteinesulfinic acid and L-homocysteic acid]. PMID- 4331050 TI - [Distribtion of phosphatides and labelling of lipidic phosphorus and mineral phosphorus of rat and calf retinas]. PMID- 4331051 TI - Plasma renin activity in the rabbit with renal hypertension. PMID- 4331052 TI - Epidemic keratoconjunctivitis. PMID- 4331054 TI - Separation of bilirubin and its conjugates by thin layer chromatography. PMID- 4331053 TI - Hypothalamic mechanism of pyrogen action in the cat and monkey in: pyrogens and fever. PMID- 4331055 TI - Pharmacology of snake venoms. PMID- 4331056 TI - [Vaccination tests against Marek's disease by application of an attenuated Marek Herpes-virus and a Herpes-virus of turkey]. PMID- 4331057 TI - [The fluorescent antibody technic for the diagnosis of equine herpes virus abortion in comparison with conventional diagnostic methods]. PMID- 4331058 TI - Chemical structure and biochemical activity of cord factor analogs. 6,6' Dimycoloyl sucrose and methyl 6-mycoloyl- -D-glucoside. PMID- 4331059 TI - [Diagnosis and prevention of iron deficiency in blood donors]. PMID- 4331060 TI - Pteroylglutamic acid in cerebrospinal fluid. PMID- 4331061 TI - Mechanisms of active transport in isolated membrane vesicles. 2. The coupling of reduced phenazine methosulfate to the concentrative uptake of beta-galactosides and amino acids. PMID- 4331062 TI - The significance of triiodothyronine (T3) in maintenance of euthyroid status after treatment of hyperthyroidism. PMID- 4331064 TI - Thyroid dysfunction in pseudohypoparathyroidism. PMID- 4331063 TI - Radioimmunoassay of plasma estriol. PMID- 4331065 TI - Studies on tryptophan metabolism in male subjects treated with hydrocortisone. PMID- 4331066 TI - Inadequate adrenal reserve. PMID- 4331067 TI - Absent sleep peak of growth hormone release in blind subjects: ccorrelation with sleep EEG stages. PMID- 4331068 TI - Structural changes associated with inhibition of involution of the mammary gland in the albino rat. PMID- 4331069 TI - Renin levels in the kangaroo, the wombat and other marsupial species. PMID- 4331070 TI - Oxandrolone treatment of short stature: effect on predicted mature height. PMID- 4331071 TI - Photoinduced hole-electron recombination in a -irradiated single crystal of L cystine dihydrochloride. PMID- 4331072 TI - [Prevention of rickets]. PMID- 4331073 TI - [Uremic neuropathy]. PMID- 4331074 TI - Prophylactic chemotherapy of patients with molar pregnancy. PMID- 4331075 TI - Some relationships between adrenal function and the effectiveness of a period of isolation in inducing intermale aggression in albino mice. PMID- 4331076 TI - Behavioral inhibition as modified by melanocyte-stimulating hormone (MSH) and light-dark conditions. PMID- 4331077 TI - Cue value of dexamethasone for fear-motivated behavior. PMID- 4331078 TI - [Effects of repetitive electric stimulation of the vermis during sleep with fast cortical activity]. PMID- 4331079 TI - Quantum aspects of central and ganglionic synaptic transmission in vertebrates. PMID- 4331080 TI - [Prostaglandins: important tissue hormones]. PMID- 4331081 TI - A unique synaptosomal fraction, which accumulates glutamic and aspartic acids, in brain tissue. AB - Subcellular fractionation of rat cerebral cortical slices on sucrose density gradients provides evidence for the existence of a unique synaptosomal fraction (enriched in pinched-off nerve endings) that selectively accumulates glutamic and aspartic acids. The particles in this fraction sediment to a less dense portion of sucrose gradients than do particles that accumulate aromatic, basic, and neutral (large and small) amino acids. Particles that store gamma-aminobutyric acid are even less dense than those that contain exogenous glutamic and aspartic acids. The distribution of endogenous glutamic acid encompasses both that of exogenous glutamic acid and that of the neutral and basic amino acids. These findings provide neurochemical support for the suggestion that glutamic and/or aspartic acid has a specialized synaptic function, perhaps as a neurotransmitter, in the mammalian brain. PMID- 4331082 TI - Antibody formation: reduced responses after administration of excessive amounts of nonspecific stimulators. AB - Enhancement of antibody formation in vitro and in vivo by poly(A.U), cyclic AMP, dibutyryl cyclic AMP, or any one of these agents in combination with theophylline or caffeine, is usually limited to certain dose ranges. High doses of these nonspecific stimulators can produce less or no enhancement, or may actually inhibit antibody formation. Such dose-response relationships may be pertinent to an understanding of phenomena of specific immunological nonresponsiveness and certain types of antigenic competition. PMID- 4331083 TI - Analysis of the events leading to SV40-induced chromosome replication and mitosis in primary mouse kidney cell cultures. AB - Abortive infection with simian virus 40 in confluent, "contact-inhibited", mouse kidney cell cultures was studied. The sequential events, in individual cells, are tentatively represented by the simplified scheme: (a) transcription of early virus-specific (messenger) RNA; (b) appearance of T-antigen; (c) [psychrosensitive event(s)]; (d) chromosome replication; (e) normal or abnormal mitosis. No evidence for the replication of viral progeny DNA was obtained. The sequence of the events (a)-(d) is analogous to that observed in contact-inhibited mouse kidney tissue culture cells during lytic infection with polyoma virus. PMID- 4331084 TI - Purification and DNA-binding properties of the catabolite gene activator protein. AB - A protein required for the activation of the lac operon has been extensively purified and partly characterized. This protein, called CGA protein (catabolite gene activator protein, sometimes named CAP), is a dimer with subunits of 22,000 daltons. Purified CGA protein has a substantial affinity for DNA; this affinity is greatly strengthened by cAMP and strongly inhibited by cGMP. Other studies have shown that these cyclic nucleotides compete for a binding site on CGA protein. The opposing effects of the two cyclic compounds in DNA-CGA protein binding show a parallel behavior to their effects on the expression of the lac operon. Thus cAMP, in addition to CGA protein, is required for expression of the lac operon, whereas cGMP inhibits the expression. The obvious inference is that CGA protein activates the lac operon by binding to the DNA under the influence of cAMP. Thus, CGA protein seems to be a new type of regulatory protein: a DNA binding activator. PMID- 4331085 TI - Bent fatty acid chains in lecithin bilayers. AB - An analysis of the paramagnetic resonance spectra of a number of phospholipid spin labels in multi-lamellar arrays of lecithin bilayers has been carried out in terms of a distribution of label orientations, and the amplitude and time dependence of high-frequency random motions about these orientations. This analysis indicates that there is a long-lived (>10(-8) sec) average bending of the fatty acid chains such that near the polar head groups the chains are comparatively rigid and tilted at about 30 degrees relative to a normal to the bilayer plane, whereas near the terminal methyl groups the chains are flexible and on the average parallel to this normal. This bent conformation of the chains permits the packing of chains into planar lamellar arrays even when different segments of the chain have different motional freedom. PMID- 4331086 TI - Mechanism of action of 1,25-dihydroxycholecalciferol on intestinal calcium transport. AB - The prior administration of actinomycin D prevents the metabolism of [(3)H]25 hydroxycholecalciferol to 1,25-dihydroxycholecalciferol, a metabolite of vitamin D(3) that is effective in the stimulation of intestinal calcium transport. In this paper, the question of whether the response of intestinal calcium transport to 1,25-dihydroxycholecalciferol is sensitive to actinomycin D was examined. While the response of intestinal transport to physiological amounts of 25 hydroxycholecalciferol is blocked by actinomycin D, the response of intestinal calcium transport to 1,25-dihydroxycholecalciferol is insensitive to the antibiotic. These results suggest that 1,25-dihydroxycholecalciferol, or a further metabolite thereof, is the metabolically active form of vitamin D in the intestine, that it functions by a process not involving transcription of DNA, and that the step sensitive to actinomycin D in the action of vitamin D on the intestine does not occur in the intestine, but is the conversion of 25 hydroxycholecalciferol to 1,25-dihydroxycholecalciferol in the kidney. PMID- 4331087 TI - Restoration of contact-inhibited growth to transformed cells by dibutyryl adenosine 3':5'-cyclic monophosphate. AB - Spontaneously transformed and virally-transformed cells are restored to contact inhibited growth by the addition of dibutyryl cyclic AMP to the nutrient medium. Theophylline, an inhibitor of the phosphodiesterase that degrades cyclic nucleotides, must also be present for maximal effect. Once the transformed cells reach a saturation density in the presence of the additives, release from the contact-inhibited state occurs upon removal of the dibutyryl cyclic AMP and theophylline from the medium. Agglutinability of the transformed cells by wheat germ agglutinin (a monitor of architectural changes in the plasma membrane) is decreased by dibutyryl cyclic AMP-theophylline treatment, but increases again upon removal of the additives. PMID- 4331088 TI - Effect of double-stranded viral RNA on mammalian cells in culture. AB - During bovine enterovirus infection of Ehrlich ascites tumor cells, large amounts of double-stranded RNA accumulate. Addition of this double-stranded RNA to uninfected cells leads to rapid cell death. This is not a result of infectious virus production. Neither single-stranded RNA nor heat-denatured double-stranded RNA has this effect. Similar experiments with synthetic double-stranded polymers, poly(I).poly(C) and poly(A).poly(U), show that they are only slightly toxic at the concentrations used. The effect of the double-stranded RNA is nonspecific for cells of different origins. The implications of this finding in relation to the cytopathic effects of picornavirus and to cancer chemotherapy are discussed. PMID- 4331090 TI - Removal of cell-associated myxovirus by antibody. PMID- 4331089 TI - In vitro detection of cytotoxic cellular immunity against tumor-specific antigens by a radioisotopic technique. AB - [(3)H]Thymidine-labeled tumor cells are used to evaluate the cytotoxic cellular immune response against tumor-specific antigens; the loss of label due to destruction and detachment of target cells from the surface of the culture vessel is measured. Spleen cells from mice immunized against Moloney virus-induced rhabdomyosarcoma specifically destroyed the sarcoma cells, while cells from normal syngeneic mice did not. Peripheral blood lymphocytes from patients with malignant tumors were specifically cytotoxic to autologous tumor cells and to allogeneic tumor cells histopathologically identical to the autologous tumor, but not to autologous nonmalignant fibroblasts, or to allogeneic tumor cells from a histologically dissimilar tumor. Serum from the same patients specifically protected autologous tumor cells from lymphocyte cytotoxicity. This serum mediated protection of tumor cells against autologous cellular immunocytotoxicity also extended to histologically identical allogeneic tumor cells. Cross reactivity of anti-tumor cellular immunocytotoxicity in vitro, and its "blocking" by autologous serum, strongly suggest the presence of common tumor antigens. The antagonism demonstrated in vitro between serum and cellular immunity may explain the continued growth of malignant tumors in the face of demonstrable cellular immunity. PMID- 4331092 TI - Comparative study of the efficacy of different forms of interferon therapy in the treatment of mice challenged intranassaly with vesicular stomatitis virus (VSV). PMID- 4331093 TI - Accelerated transformation by polyoma virus in rat embryo cells infected with Rauscher Leukemia virus. PMID- 4331091 TI - Type-specific surface antigens of cells infected with herpes simplex virus (1 and 2). PMID- 4331094 TI - Interferon levels and resistance to viral infection associated with selected interferon inducers. PMID- 4331095 TI - Enhanced mitochondrial functions during heptatocarcinogenesis. PMID- 4331096 TI - Inhibitory effect of ethanol upon aldosterone synthesis by beef adrenal tissue. PMID- 4331097 TI - Inhibition of marrow growth by cyclic AMP. PMID- 4331098 TI - The chemotactic properties of the products of collagenolysis. PMID- 4331099 TI - [Abnormality in ontogeney and phylogeney in cancer cells with special reference to nitrogen metabolism]. PMID- 4331100 TI - Further studies on porcine enteroviruses isolated at Cambridge. I. Infections in SPF pigs and the preparation of monospecific antisera. PMID- 4331101 TI - Further studies on porcine enteroviruses isolated at Cambridge. II. Serological grouping. PMID- 4331102 TI - Inclusion-body rhinitis of pigs: an experimental study of some factors that affect the incidence of inclusion bodies in the nasal mucosa. PMID- 4331103 TI - Viral encephalomyelitis of equines and domestic ruminants in the Near East. I. PMID- 4331104 TI - [Effect of oxygen dificiency and cardiac insufficiency on glucocorticoid activity of the adrenal cortex]. PMID- 4331105 TI - Blocking of guanidine action on poliovirus multiplication. PMID- 4331106 TI - The DNA of murine sarcoma-leukemia virus. PMID- 4331107 TI - The DEAE dextran:polyriboinosinate-polyribocytidylate complex: physical properties and interferon induction. PMID- 4331108 TI - Biogenesis of poxviruses: identification of four enzyme activities within purified Yaba tumor virus. PMID- 4331109 TI - Formation of small plaques by herpes viruses irradiated with ultraviolet light. PMID- 4331110 TI - Temperature-sensitive mutants of vesicular stomatitis virus. II. Evidence of defective polymerase. PMID- 4331111 TI - Intracellular interferon: kinetics of formation and release. PMID- 4331112 TI - Stability of polycation-induced cell competence for infection by viral RNA. PMID- 4331113 TI - Lack of requirement of murine leukemia virus for early steps in infection of mouse embryo cells by murine sarcoma virus. PMID- 4331114 TI - Clinical studies of abdominal tumors in infants and children--ten year review. PMID- 4331115 TI - Primary liver tumors in infancy and childhood--6 cases report. PMID- 4331116 TI - Histopathological studies on gastric carcinoma among Koreans. PMID- 4331117 TI - [Diagnosis of the salivary gland diseases with radioisotope technetium-99]. PMID- 4331118 TI - Current concepts of synaptic structure and function. PMID- 4331119 TI - [Ultrastructural aspects of herpetic stomatitis]. PMID- 4331120 TI - Long-range nonradiative transfer of electronic excitation energy in proteins and polypeptides. PMID- 4331121 TI - Biosynthesis of spin-labelled phospholipids. Enzymatic incorporation of spin labelled stearic acid into phosphatidic acid. PMID- 4331122 TI - Evidence for the existence and functional activity of the pentose phosphate pathway in the large particle fraction isolated from rat tissues. PMID- 4331123 TI - Preparation and properties of apopyrocatechase. PMID- 4331124 TI - Distribution of initiation factors in cell fractions from mammalian tissues. PMID- 4331125 TI - Effect of 3'5'-AMP on calcium-activated ATPase in rat heart sarcolemma. PMID- 4331126 TI - Cyclic AMP phosphodiesterase interaction with its inhibitor of the slime mold, Dictyostelium discoideum. PMID- 4331127 TI - Rotational correlation time of spin-labeled alpha-chymotrypsin. PMID- 4331128 TI - Dissociation of rabbit red blood cell cyclic AMP-dependent protein kinase I by protamine. PMID- 4331129 TI - Distinctive effects of inhibitors of mitochondrial function on Rous sarcoma virus replication and malignant transformation. PMID- 4331130 TI - Detection of a lysosomal carboxypeptidase and a lysosomal dipeptidase in highly purified dipeptidyl aminopeptidase I (cathepsin C) and the elimination of their activities from preparations used to sequence peptides. PMID- 4331131 TI - Vitamin D3 induced alteration of microvillar membrane lipid composition. PMID- 4331132 TI - Cyclic 3'.5'-nucleotide phosphodiesterase. Effect of binding protein on the hydrolysis of cyclic AMP. PMID- 4331133 TI - In vivo induction of the effector system for luteinizing hormone in white adipocytes of the rat. PMID- 4331134 TI - Apparent distinctiveness of the actions of gibberellic acid in aleurone layers. PMID- 4331135 TI - Stimulation of ribosomal and DNA-like RNA synthesis by tryptophan. PMID- 4331136 TI - Methylated polydeoxyribocytidylic acid templates for RNA polymerase. PMID- 4331137 TI - tRNA and aminoacyl-tRNA synthetases during differentiation and various functional states of the mammary gland. PMID- 4331138 TI - The phospholipid composition of guinea-pig skin in relation to endogenous respiration. PMID- 4331139 TI - Intraductal carcinoma of the breast. (1960-1969). PMID- 4331140 TI - Relationship of tumor grade, stage and host response in a group of breast neoplasms. PMID- 4331141 TI - Ultrastructure of functioning beta cell tumors of the pancreatic islets. PMID- 4331142 TI - [Treatment of parathyroid diseases]. PMID- 4331143 TI - The management of recurrent gliomas. PMID- 4331144 TI - Exchange transfusion treatment of fulminating canine viral hepatitis: the role of specific antiviral antibody. PMID- 4331145 TI - Distribution of ampicillin administered orally in three different forms in rabbit. PMID- 4331146 TI - Electron microscopic study of the secretion of some bacterial enzymes and toxins. PMID- 4331147 TI - [Ultrastructural study of the replication cycle of an entomopoxvirus in the hemocytes of its host]. PMID- 4331148 TI - A freeze-fracture study of bullfrog gastric oxyntic cells. PMID- 4331149 TI - [Ultrastructure of the proctodeum of the thysanuran Lepismodes inquilinus Newman (+Thermobia domestica Packard). II. The anal sac]. PMID- 4331150 TI - Unusual features of the T-system of the pectoralis muscle of the chicken. PMID- 4331151 TI - The structure of the milk fat globule membrane. PMID- 4331152 TI - Ultrastructural studies on the synaptology of the inferior mesenteric ganglion of the cat. I. Observations on the cell surface of the postganglionic perikarya. PMID- 4331153 TI - Clinical significance of circulating proinsulin. PMID- 4331154 TI - Regulation of adenosine cyclic 3',5'-phosphate formation in cerebral cortical slices. Interaction among norepinephrine, histamine, serotonin. PMID- 4331155 TI - Effect of hypophysectomy on adrenal dopamine -hydroxylase activity in the rat. PMID- 4331156 TI - Phosphatase and ouabain-sensitive adenosine triphosphatase activities of the perfused frog heart. PMID- 4331157 TI - Pituitary function. PMID- 4331158 TI - Benefit from alternate-day prednisone in myasthenia gravis. PMID- 4331159 TI - Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 1-1972. PMID- 4331160 TI - [EB virus--migrant or immigrant?]. PMID- 4331161 TI - Early membrane depolarization of the fast mammalian muscle after denervation. PMID- 4331162 TI - Cleavage and differentiation in the sea urchin embryo. Transplantation studies of micromeres. PMID- 4331163 TI - Counting of gas vacuoles by electron microscopy in lysates and purified fractions of Microcystis aeruginosa. PMID- 4331164 TI - The influence of sucrose, 2,4-D, and kinetin on the growth, fine structure, and lignin content of cultured sycamore cells. PMID- 4331165 TI - Periodicity of endocytosis in Tetrahymena pyriformis. PMID- 4331166 TI - A study of the biochemistry and cytochemical localization of -glycerophosphatase activity in root tips of maize and pea. PMID- 4331167 TI - Effects of phosfon-D and of low temperature on the morphology of cell protoplasts. PMID- 4331169 TI - [Attempted infection of Chad goats by bovine infections rhinotracheitis virus. Serological survey in West Chad]. PMID- 4331168 TI - Corticoadrenal stimulation with different doses of a repository tetracosapeptide. PMID- 4331170 TI - [Preliminary studies of porcine piroplasmosis in the northern Ivory Coast. Demonstration of Babesia Traumanni Knut and Du Toit, 1921, and attempted experimental transmission]. PMID- 4331171 TI - Inheritance of haemoglobin H disease. A new aspect. PMID- 4331172 TI - Efforts toward a more useful viral diagnostic laboratory. PMID- 4331173 TI - A method for determining sensitivities of antiviral drugs in vitro for possible use as clinical consultation. PMID- 4331174 TI - [The concept of blastema tumors]. PMID- 4331175 TI - [Successive bronchial carcinomas. Apropos of a case]. PMID- 4331176 TI - The effect of arecoline on transmission through the superior cervical ganglion of the cat. PMID- 4331178 TI - Changes in the proportions of two mitochondrial populations during the development of embryonic chick liver. AB - 1. Two populations of morphologically intact mitochondria were isolated from embryonic, neonatal and adult chick liver by isopycnic centrifugation. 2. The protein/phospholipid ratio of the total mitochondrial fraction, the low-density mitochondria (B2, d1.176) and the high-density mitochondria (B3, d1.206) did not differ significantly. 3. During development there is a marked increase in the B2 fraction in relation to the B3 fraction. 4. Cytochrome oxidase and malate dehydrogenase activities as well as respiratory control increased during the embryonic development of the chick, though their rates of increase were not correlated. 5. In the three different embryonic stages that were investigated, as well as in the neonatal and adult chick, the protein/lipid as well as the protein/phospholipid ratio stayed constant and showed no progressive increase, as had been previously reported. 6. It was shown that forces greater than 18400g(av.) for 2h have to be used before chick liver mitochondria reach isopycnic equilibrium. 7. As for rat liver mitochondria, the constant protein/phospholipid ratio of the B2 and B3 fractions and their apparent morphological intactness leads one to conclude that the matrix space of B2 mitochondria is inaccessible to sucrose, whereas B3 mitochondria possess an inner membrane that is permeable to sucrose. PMID- 4331177 TI - Biosynthesis of carotenoids and plant triterpenes. PMID- 4331179 TI - The regulatory proteins of the myofibril. Characterization and properties of the inhibitory factor (troponin B). AB - 1. Gel-filtration results indicate that the major component of inhibitory-factor preparations isolated by dissociation of the troponin complex consisted of a protein of subunit weight 23000 daltons. By the same procedure a molecular weight of 18000 was obtained for the calcium-sensitizing factor. 2. The inhibitory factor is specific for the actomyosin type of ATPase and ITPase. It is effective on desensitized actomyosin, natural actomyosin and intact myofibrils. 3. For inhibition, the actomyosin ATPase must be stimulated by Mg(2+), Ca(2+) or Mn(2+). The Co(2+)-, Cd(2+)- or Zn(2+)-stimulated ATPases are not affected. 4. Biological activity is stable to treatment with dissociating agents, heat, pH11, pH1 and carboxymethylation. 5. Increasing amounts of actin, but not myosin or tropomyosin, progressively neutralize the inhibitory activity when added to desensitized actomyosin or myofibrils. PMID- 4331180 TI - The structure of a glycopeptide purified from porcine thyroblobulin. AB - 1. The structure of a purified glycopeptide isolated from porcine thyroglobulin was studied by sequential hydrolysis with specific glycosidases, by periodate oxidation and by treatment with galactose oxidase. 2. Sequential hydrolysis with several combinations of neuraminidase, alpha-l-fucosidase, beta-d-galactosidase, beta-N-acetyl-d-glucosaminidase and alpha-d-mannosidase presented the evidence for the following structure. 3. The monosaccharide sequence of the peripheral moiety of the heteropolysaccharide chain was sialic acid-->galactose-->N acetylglucosamine. Some of the galactose residues were non-reducing end-groups with the sequence galactose-->N-acetylglucosamine. 4. After removal of the peripheral moiety composed of sialic acid, fucose, galactose and N acetylglucosamine, alpha-mannosidase released 1.4mol of mannose/mol of glycopeptide, indicating that two of the three mannose residues were located between peripheral N-acetylglucosamine and internal N-acetylglucosamine or mannose. 5. Periodate oxidation and sodium borohydride reduction confirmed the results obtained by enzymic degradation and gave information concerning the position of substitution. 6. Based on the results obtained by enzymic hydrolysis and periodate oxidation together with the treatment with galactose oxidase, a structure is proposed for the glycopeptide. PMID- 4331181 TI - The inhibition of glutamate dehydrogenase by L-serine O-sulphate and related compounds and by photo-oxidation in the presence of Rose Bengal. AB - 1. Glutamate dehydrogenase was inhibited by l-serine O-sulphate, beta-chloro-l alanine, O-phospho-l-serine and beta-chloro-l-alanine methyl ester. With the exception of beta-chloro-l-alanine methyl ester which was an irreversible inhibitor, it was possible to reverse the inhibitory effects by dialysis. 2. Both NAD(+) and glutamate afford some protection against the inhibition due to the methyl ester. No change in the normal stimulatory effect exhibited by ADP was observed in the presence of beta-chloro-l-alanine methyl ester but the effect due to GTP was modified. 3. Irradiation of glutamate dehydrogenase in the presence of Rose Bengal produced rapid inactivation. Amino acid analysis of the inactivated enzyme showed that eight histidine residues had been destroyed in the process. PMID- 4331182 TI - [Lysosomes and lipid inclusions in mucosal cells in chronic gastritis]. PMID- 4331183 TI - [Change in blood serotonin concentration and in thrombocyte 5-HT-organelles in the rabbit in acute radiation sickness]. PMID- 4331184 TI - [Some indices of kidney carbohydrate metabolism and peripheral blood phosphohexoisomerase activity at different stages of traumatic shock]. PMID- 4331185 TI - [Interzonal and intrazonal connections of the somatosensory cortex]. PMID- 4331186 TI - [Antiviral and interferogenic action of polyadenylic and polyuridylic acid complexes]. PMID- 4331187 TI - [Pathways of activation of mesencephalic reticular formation neurons]. PMID- 4331188 TI - [Auto- and cross-correlation analysis of reactions of vasomotor center neurons to adequate stimulation of the vestibular apparatus]. PMID- 4331189 TI - [Treatment of lung cancer with cyclophosphamide from the cytological point of view]. PMID- 4331190 TI - [Comparative results of the treatment of bronchial cancer]. PMID- 4331192 TI - Mixed tumor of parotid gland: report of a case. PMID- 4331191 TI - [Influence of hypothalamus on the corticostimulating activity of the rat fetal hypophysis during pregnancy]. PMID- 4331193 TI - [Malignant lymphoma with cytomegalovirus infection--an autopsy case of an adult]. PMID- 4331194 TI - Effect of silicotungstate on reduced diphosphopyridine nucleotide oxidation in submitochondrial particles. PMID- 4331195 TI - The mode of action of dibutyryl adenosine 3',5'-monophosphate on bone tissue in vitro. PMID- 4331196 TI - Glycolipid synthesis in the early prereplicative phase of isoproterenol stimulated salivary glands of mice. PMID- 4331197 TI - Formation and release of a hormone antagonist by rat adipocytes. PMID- 4331198 TI - On the composition of anthranilate synthetase-anthranilate 5 phosphoribosylpyrophosphate phosphoribosyltransferase from Salmonella typhimurium. PMID- 4331200 TI - Ligand interactions with yeast aldehyde dehydrogenase. PMID- 4331199 TI - Purification and properties of kaurene synthetase from Fusarium moniliforme. PMID- 4331201 TI - The biosynthesis of the nucleoside antibiotics. IX. Purification and properties of guanosine triphosphate 8-formylhydrolase that catalyzes production of formic acid from the ureido carbon of guanosine triphosphate. PMID- 4331202 TI - The nucleotide sequence of a low molecular weight ribonucleic acid from cells infected with adenovirus 2. PMID- 4331203 TI - Streptomycin biosynthesis. Separation and substrate specificities of phosphatases acting on guanidinodeoxy-scyllo-inositol phosphate and streptomycin (streptidino)phosphate. PMID- 4331204 TI - Electron spin resonance of metallocarbonic anhydrases. PMID- 4331205 TI - Reconstitution of the third site of oxidative phosphorylation. PMID- 4331206 TI - Further studies on synaptic transmission in insects. II. Relations between sensory information and its synaptic integration at the level of a single giant axon in the cockroach. PMID- 4331207 TI - Coxal depressor muscles of the cockroach and the role of peripheral inhibition. PMID- 4331208 TI - Patterned activity of the buccal ganglion of the nudibranch mollusc Archidoris pseudoargus. PMID- 4331209 TI - Comparison of gentamicin and polymyxin B-kanamycin in therapy of bacteremia due to gram-negative bacilli. PMID- 4331210 TI - Gentamicin and kanamycin in the treatment of gram-negative sepsis: a comparative study. PMID- 4331211 TI - Intravenous gentamicin for infectious complications in children with acute leukemia. PMID- 4331212 TI - Gas-liquid chromatography with high resolution glass capillary columns for the simultaneous determination of urinary steroids. PMID- 4331213 TI - Colloid (mucus secreting) carcinoma of the cervix. PMID- 4331214 TI - Experience of a geriatric crisis intervention screening team. PMID- 4331215 TI - One approach to real community involvement. PMID- 4331217 TI - Play therapy for a regressed schizophrenic patient. PMID- 4331216 TI - The fourth R in nursing education. PMID- 4331218 TI - A phenomenological approach to understanding suicidal behavior. PMID- 4331219 TI - Available nurses and need for nurses. PMID- 4331221 TI - A practical faith in psychiatric counseling. PMID- 4331220 TI - Student evaluations of an interactional group experience: a follow-up study. PMID- 4331222 TI - The utilization of non-professionals in a sheltered boarding care program. PMID- 4331223 TI - Man, woman, and work. PMID- 4331225 TI - Anxiety in a Jewish patient. PMID- 4331224 TI - Community facilities for the elderly. PMID- 4331226 TI - Effects of marihuana on adolescents and young adults. PMID- 4331227 TI - Nasal packs for epistaxis. PMID- 4331228 TI - [Some indices of the functional state of the adrenal cortex and electrolyte metabolism in primary arterial hypotension]. PMID- 4331229 TI - [Some metabolic characteristics in the myocardium during acute blood deficits under conditions of hyperbaric oxygenation]. PMID- 4331230 TI - [Experimental data on the effect of strophanthin on several aspects of metabolism in the uninjured areas of the myocardium in infarction]. PMID- 4331231 TI - Phenotypic reversion in some early blocked sporulation mutants of Bacillus subtilis. Genetic study of polymyxin resistant partial revertants. PMID- 4331232 TI - [Tumors in infants and children]. PMID- 4331233 TI - [Mechanisms of regulation of the mammary gland secretory function. Effect of anterior pituitary hormones on milk secretion]. PMID- 4331234 TI - [Chronic lymphoid leukemia with cristals with non-excreted intracellular monoclonal macroglobulin]. PMID- 4331235 TI - Boarding out since St. Dymphna. PMID- 4331236 TI - Effect of some hormones on the osmotic resistance of leukocytes. PMID- 4331237 TI - [Early uremic polyneuropathy. Electromyographic study]. PMID- 4331238 TI - [The Grob test in myasthenia: discussion of an atypical case]. PMID- 4331239 TI - Lipids and brain development. PMID- 4331240 TI - Postnatal development of tetraploid DNA content in the Purkinje neuron of the rat: an aspect of cellular differentiation. PMID- 4331241 TI - [Electron microscopic studies on membrane-phosphatases and lysosomes in the proximal tubule of the rat kidney after application of folic acid]. PMID- 4331242 TI - Alterations of the adrenal cortex of rats treated with progesterone. PMID- 4331243 TI - Effect of ACTH on the nucleolar size of adrenal cortical cells and of liver cells. An electron-microscopic study using a quantitative biometrical method. PMID- 4331244 TI - Effect of nemibutal and nialamide on the pars intermedia and skin colour changes in Rana cyanophlyctis Schneider. PMID- 4331245 TI - Analysis of total, grouped, and individual urinary 17-ketosteroids: a critical evaluation. PMID- 4331246 TI - Studies on growth hormone secretion. II. Stimulation by prostaglandins in vitro. PMID- 4331247 TI - Urinary total 17-hydroxycorticosteroid output in intact and ovariectomized bitches. PMID- 4331248 TI - [Therapy of psoriasis using dehydroepiandrosterone-sulfate]. PMID- 4331249 TI - [Changes in blood pressure regulating reflexes under neuroleit-analgesia]. PMID- 4331250 TI - Actively and passively acquired antibody to mucosal disease and parainfluenza type 3 viruses in sheep. PMID- 4331251 TI - Equine herpesviruses. 4. Concurrent infection in horses with strangles and conjunctivitis. PMID- 4331252 TI - Herpesviruses isolated from cheetahs. PMID- 4331253 TI - Canine herpesvirus from a pup in Western Australia. PMID- 4331254 TI - A comparison of mitochondria from Torulopsis utilis grown in continuous culture with glycerol, iron, ammonium, magnesium or phosphate as the growth-limiting nutrient. AB - 1. Mitochondria prepared from Torulopsis utilis grown in a chemostat with iron limited growth were found to lack energy conservation but not electron flow in that segment of the respiratory chain leading from intramitochondrial NADH to the cytochromes [i.e. the site 1 segment (Lehninger, 1964)]. 2. Site 1 energy conservation was present in mitochondria prepared from cells grown under conditions of limitation by glycerol, ammonium and magnesium. Phosphate-limited growth resulted in mitochondrial preparations without respiratory control. 3. Mitochondria from cells grown under conditions of iron limitation were insensitive to the respiratory inhibitor piericidin A, whereas sensitivity was present in mitochondria prepared from glycerol-, ammonium-, magnesium- or phosphate-limited cells. 4. These observations are considered to provide indirect evidence for a role of non-haem iron in the mechanism of energy conservation and also piericidin A sensitivity in T. utilis mitochondria. 5. A readily constructed and inexpensive pH-measuring and -controlling circuit is described for use with continuous-culture apparatus. PMID- 4331255 TI - Non-haem iron and the dissociation of piericidin A sensitivity from site 1 energy conservation in mitochondria from Torulopsis utilis. AB - 1. The aerobic incubation of iron-deficient Torulopsis utilis cells for 12h under non-growing conditions results in the recovery by mitochondria of the previously absent site 1 energy conservation and sensitivity to piericidin A. 2. The recovery of piericidin A sensitivity but not site 1 is prevented by the presence of cycloheximide (100mug/ml) in the medium used for aerobic incubation of the cells. Rotenone sensitivity behaved similarly. 3. Chloramphenicol, erythromycin and tetracycline were without effect on the recovery of site 1 and piericidin A sensitivity. 4. Inclusion of (59)Fe in the growth medium can be used as the basis for a highly sensitive assay for non-haem iron. 5. Iron-limited growth of T. utilis lowers the concentration of both non-haem iron and acid-labile sulphide of submitochondrial particles by over 20-fold compared with the ;normal' situation with iron-supplemented glycerol-limited growth. 6. Increases in the non-haem iron and acid-labile sulphide concentrations of submitochondrial particles occur when site 1 and piericidin A sensitivity are recovered. The increase is approximately halved by the presence of cycloheximide. 7. The non-haem iron of T. utilis submitochondrial particles does not exchange with added iron. 8. Continuous culture of T. utilis at the transition between glycerol- and iron-limitation results in cells where mitochondria possess site 1 energy conservation but lack piericidin A sensitivity. 8. It is concluded, in contrast with widely held views to the opposite, that energy conservation at site 1 does not require electron flow to proceed through a piericidin A- or rotenone-sensitive route. 9. Restriction of the iron supplied to growing T. utilis to a concentration just above that required for growth limitation demonstrates that a 10- to 20-fold decrease of the ;normal' non-haem iron concentration of both cells and mitochondria is without effect on the growth yield per unit of carbon source. Submitochondrial particles prepared from such iron-restricted but otherwise functionally normal cells have a non-haem iron concentration of about 0.5-0.8ng atom/mg of protein. It is concluded that the concentration of iron-sulphur protein required for normal function by the respiratory chain is close to the concentrations of cytochromes and flavoproteins. PMID- 4331256 TI - Changes in histone phosphorylation and associated early metabolic events in pig lymphocyte cultures transformed by phytohaemagglutinin or 6-N,2'-O dibutyryladenosine 3':5'-cyclic monophosphate. AB - 1. Pig lymphocytes were transformed by dibutyryl cyclic AMP (6-N,2'-O dibutyryladenosine 3':5'-cyclic monophosphate) at concentrations of 0.01-0.1mum. The pattern of incorporation of label from [5-(3)H]uridine and [6-(3)H]thymidine into RNA and DNA respectively was identical with that obtained with unpurified phytohaemagglutinin. 2. Chlorpromazine (0.1mum) prevented the stimulation of [5 (3)H]uridine incorporation into RNA by phytohaemagglutinin, but only slightly lowered the lymphocyte response to dibutyryl cyclic AMP. 3. An increase in the size and specific radioactivity of the intracellular P(i) pool was found immediately after stimulation by both phytohaemagglutinin and dibutyryl cyclic AMP. This was followed after some 30min by a rise in the specific radioactivity and concentration of ATP. 4. There was an immediate increase in the specific radioactivity of phosphate groups of histones; by about 45min after stimulation only the histones remaining after extraction of histone fraction F1 continued to incorporate (32)P from [(32)P]P(i). 5. Histone kinase activity increased in the first 30min after stimulation; subsequently histone F1 kinase activity decreased, but activity with the other histones as substrate continued to increase for a further 30min. Kinase activation was effected by cyclic AMP (adenosine 3':5' cyclic monophosphate). 6. Histone phosphatase activity behaved similarly to that of the kinase. PMID- 4331257 TI - Functional and structural changes in liver mitochondria of rats due to CCl 4 intoxication. I. Studies on state of electron-transport chain. PMID- 4331264 TI - Effect of 1-)0-chlorophenyl)-1-(p-chlorophenyl)-2,2-dichloroethane on adrenocorticotropic hormone-induced steroidogenesis in various preparations in vitro of dog adrenal cortex. PMID- 4331265 TI - Effect of 1-(o-chlorophenyl)-1-(p-chlorophenyl)-2, 2-dichloroethane in vivo on baseline and adrenocorticotropic hormone-induced steroid production in dog adrenal slices. PMID- 4331268 TI - The iron electron-nuclear double resonance (ENDOR) of two-iron ferredoxins from spinach, parsley, pig adrenal cortex and Pseudomonas putida. PMID- 4331269 TI - The two-iron ferredoxins in spinach, parsley, pig adrenal cortex, Azotobacter vinelandii, and Clostridium pasteurianum: studies by magnetic field Mossbauer spectroscopy. PMID- 4331270 TI - Characteristics of myosin modified by -hydroxyethyl-2,4-dinitrophenyl disulphide in the presence of pyrophosphate. PMID- 4331271 TI - Electron paramagnetic resonance studies on the nature of hemoproteins in nitrite and nitric oxide reduction. PMID- 4331273 TI - The electron paramagnetic resonance of molybdenum in rat liver and in rat liver mitochondria. PMID- 4331272 TI - Studies on the stabilization of an oxidative phosphorylation system. I. Resistance of a phosphorylating system of submitochondrial particles to trypsin, due to phosphorylation of ADP. PMID- 4331274 TI - The effect of aggregating agents on oxidative metabolism of rabbit platelets. PMID- 4331275 TI - Purification and properties of cytochrome c 555 from a protozoan, Crithidia fasciculata. PMID- 4331276 TI - The case for the Renshaw cell. PMID- 4331277 TI - [Response of the hypothalamo-hypophyseal complex of the rat fetus to a blocking of corticosteroid biosynthesis by metopirone. Infleunce of cortisol]. PMID- 4331278 TI - [Importance of the NAD-ferredoxin reductase activity in Clostridia of the butyric group]. PMID- 4331280 TI - [Effects of exogenous angiotensin on the capillaires of cortical and juxta medullary glomeruli of the rat: study with scanning electron microscopy]. PMID- 4331279 TI - [Activities of the mitochondrial enzymes in the hypothyroid rat and genetically dwarf mice]. PMID- 4331281 TI - [Demonstration of an interaction between a nitroxyde steroid and a protein by electron paramagnetic resonance]. PMID- 4331282 TI - [Purification and properties of L-arginase of papillomas induced with the rabbit papilloma virus]. PMID- 4331283 TI - [Epidemics of rhinopharyngitis caused by adenovirus type 3]. PMID- 4331284 TI - [Health of children of low birth weight at the age of 10 years. I. Pediatric examination]. PMID- 4331285 TI - Effect of ACTH on canine gastric mucus. PMID- 4331286 TI - The aetiology and pathogenesis of the malignant tumours of the liver. PMID- 4331287 TI - [Ultraviolet luminescence of mitochondria in different functional states]. PMID- 4331288 TI - [Changes in the content of some glycolysis products in the frog myocardium at different phases of the cardiac cycle]. PMID- 4331289 TI - [Intracranial neurogenic tumors in childhood]. PMID- 4331290 TI - Epilepsy in temporal lobe tumours. PMID- 4331291 TI - [Malignancy of histiocytic tumors ("Fibrous xanthomas")]. PMID- 4331292 TI - Purity control of sodium chromate- 51 Cr by separation on a kieselguhr column. PMID- 4331293 TI - Phenotypic reversion in some early blocked sporulation mutants of Bacillus subtilis: isolation and phenotype identification of partial revertants. AB - Single-step mutants of Bacillus subtilis blocked at stage zero of sporulation (spoO mutants) are pleiotropic. They are impaired in several traits, including increased sensitivity to polymyxin B, when compared to the wild type. Revertants for one or another of the traits associated in this pleiotropy have been isolated and classified according to their phenotypes. Attention was centered on partial revertants (spoO still), of which at least three classes could be recognized. Class I partial revertants recovered a high level of resistance to polymyxin and, in a constant order, a variable number of the other traits; some kind of hierarchy is thus revealed to exist among the traits affected in the original pleiotropy. Partial revertants in the other two classes are still hypersensitive to polymyxin. In class II revertants, ability to excrete exoenzymes and antibiotic(s) is recovered to various extents. Only inducibility of nitrate reductase by nitrate is recovered in class III mutants. The possible significance of these observations is discussed. PMID- 4331294 TI - Exocytosis of latex beads during the encystment of Acanthamoeba. AB - Cells of Acanthamoeba castellanii (Neff) are known to form mature cysts characterized by a cellulose-containing cell wall when transferred to a nonnutrient medium. Amebas which engulfed latex beads before encystment formed mature cysts essentially devoid of bead material. The encystment of bead containing cells appeared to be similar to that of control cells since no important differences between the two were observed with respect to cellular levels of glycogen or protein, cellulose synthetase activity, the amount of cyst wall polysaccharide formed, or the percentage of cysts formed. Actinomycin D and cycloheximide inhibited encystment as well as bead expulsion. Ultrastructural analysis revealed that the beads, which initially were contained in phagocytic vesicles, were released from the cell by fusion of vesicular membranes with the plasma membrane. Exocytosis was observed in cells after 3 hr of encystment, with most of the beads being lost before cyst wall formation. Each bead-containing vesicle involved in expulsion was conspicuously demarcated by an area of concentrated cytoplasm, which was more homogeneously granular than the surrounding cytoplasm. Beads were not observed in the cytoplasm of mature cysts but were occasionally found in the cyst wall. PMID- 4331295 TI - Nucleotide pools in Novikoff rat hepatoma cells growing in suspension culture. 3. Effects of nucleosides in medium on levels of nucleotides in separate nucleotide pools for nuclear and cytoplasmic RNA synthesis. AB - This study was undertaken to measure the absolute levels of nucleoside pools in Novikoff rat hepatoma cells (subline N1S1-67) during growth in suspension culture in the presence of high concentrations of various nucleosides in the medium, and to obtain further evidence for the compartmentalization of the nucleotides in independent cytoplasmic and nuclear pools. The levels of nucleotide pools were measured by growing the cells in medium supplemented with inorganic phosphate (32)P. The nucleotide pool levels (mostly in the form of triphosphates) ranged from about 1 nmole of cytidine nucleotides to 8 nmole of adenosine nucleotides per 10(6) cells. The presence of 1 mM uridine, cytidine, guanosine, or adenosine in the medium resulted in marked increases in the intracellular levels of the corresponding nucleoside phosphates of at least 3-4 nmole/1O(6) cells. These increases were partially compensated for by decreases in the levels of other nucleotides. Evidence is presented to indicate that it is the cytoplasmic pool that expands during incubation with high concentrations of nucleosides in the medium, whereas the nuclear pool remains constant and very small in size. Preincubation of cells with 1 mM uridine-(3)H for 5.5 hr, which resulted in a threefold increase in the total intracellular level of uridine nucleotides, had no effect on the subsequent incorporation of uridine-(14)C into cellular nucleic acids in the nucleus, whether present at a 1 microM or 1 mM concentration in the medium. In contrast, the incorporation of uridine-(14)C into cytoplasmic viral specific RNA by mengovirus-infected Novikoff cells was reduced 60-70% as a result of preincubation of the cells with high concentrations of uridine-(3)H. Further, within 1-2 min upon addition of 2.5 or 6.5 microM(3)H-labeled uridine, cytidine, adenosine, guanosine, or inosine to cultures of Novikoff rat hepatoma cells, the incorporation of label into nucleic acids reached a constant and maximum rate, in spite of the presence of high intracellular concentrations (0.4-3 mM) of the corresponding unlabeled nucleoside triphosphates. Marked differences were also observed in the relative incorporation of the various nucleosides into the different nucleotides of the acid-soluble pool, and of mengovirus RNA and cellular RNA. PMID- 4331296 TI - Unstimulated secretion of protein from rat exocrine pancreas cells. AB - Our earlier work demonstrated that the rate of protein synthesis in the exocrine cells of the rat pancreas is constant in different physiological states, including prolonged fasting. In this study we have followed the fate of the protein in the pancreatic cells of the fasting animal in vivo as well as in vitro. The data were obtained by quantitative radioautography and by biochemical determinations. In nonanesthesized, fasting rats, without cannulated pancreatic duct, some 80% of the proteins synthesized at a given time leaves the cell within 12 hr by way of secretion, intracellular breakdown not being important. Two mechanisms of fasting secretion exist. The first, starting at a slow rate after 20 min, is inferred to result from fortuitous contacts of young secretory granules with the apical cell membrane. The rate of secretion is the same in vivo as in vitro, at least during the first 4 hr after pulse labeling. Within 7 hr about 20% of the total amount of newly synthesized protein has left the cell. The second mechanism consists of an orderly movement of the mass of secretory granules towards the apical cell membrane as caused by the continuous assembly of new granules. The granules that come into contact with the cell membrane are discharged. It takes about 7-12 hr for secretory protein transported in this way to reach the cell membrane. The addition of new secretory granules to those present is essential for the second mechanism, for the blockade of protein synthesis by cycloheximide decreases the rate of this phase of secretion without interfering with the secretory process proper. Atropin does not inhibit the fasting secretion in vitro, nor does extensive washing of the tissue slices, excluding possible secretagogues as important factors in fasting secretion. PMID- 4331297 TI - Mononuclear phagocytes (Kupffer cells) and endothelial cells. Identification of two functional cell types in rat liver sinusoids by endogenous peroxidase activity. AB - The fine structural characteristics and phagocytic properties of peroxidase positive and peroxidase-negative cells in rat hepatic sinusoids were investigated. Cells with a positive peroxidase reaction in the endoplasmic reticulum and the nuclear envelope make up approximately 40% of cells in rat hepatic sinusoids and have abundant cytoplasm containing numerous granules and vacuoles, and occasional tubular, vermiform invaginations. After intravenous injection of colloidal carbon, the luminal plasma membrane of these cells shows continuous sticking of carbon, and there is evidence of avid phagocytosis of colloidal carbon particles. Peroxidase-positive cells are the only cells in hepatic sinusoids which phagocytize large (0.8 micro in diameter) latex particles. In contrast, the peroxidase-negative endothelial cells, which make up 48% of cells, have scanty perinuclear cytoplasm and organelles, and their long cytoplasmic extensions that form the lining of the hepatic sinusoids have fenestrations; these cells ingest small amounts of colloidal carbon, principally by micropinocytosis, exhibit no sticking of carbon particles to their plasma membranes, and do not ingest the larger (latex) particles. The so-called fat storing cells are peroxidase negative and totally nonphagocytic. The peroxidase reaction thus distinguishes the typical mononuclear phagocytes or Kupffer cells of rat liver from the endothelial-lining cells. PMID- 4331298 TI - Effects of puromycin on the structure of rat intestinal epithelial cells during fat absorption. AB - This report provides information on the morphology of rat intestinal epithelial cells during fat absorption. In addition, the role of protein metabolism in this process has been evaluated by blocking its synthesis with puromycin and studying the fine structure of mucosal cells from rats at various times after fat intubation. The results indicate that SER-derived vesicles, containing fat droplets, migrate from the apical cytoplasm of the absorptive cell and fuse with saccules or vacuoles of the Golgi complex. Arguments are made that the Golgi complex is important in completing chylomicron formation and in providing appropriate enveloping membranes for the chylomicron. Such membranes may be necessary for Golgi vacuoles to fuse with the lateral cell membranes and release chylomicra. Puromycin treatment causes the absorptive cell to accumulate increased quantities of lipid that are devoid of membrane during fat absorption. In addition, puromycin-treated cells contain much less RER and Golgi membranes are strikingly decreased in number. In this paper we discuss the consequences of these abnormalities and suggest that continued protein synthesis by the RER is required in order to generate Golgi membranes. If such membranes are absent the cell's ability to discarge chylomicra is impaired and lipid accumulates. PMID- 4331299 TI - Hormone-stimulated exocytosis in the toad urinary bladder. Some possible implications for turnover of surface membranes. PMID- 4331300 TI - Autophagic degradation of glycogen in skeletal muscles of the newborn rat. AB - Large amounts of glycogen accumulate in rat skeletal muscle fibers during the late fetal stages and are mobilized in the first postnatal days. This glycogen depletion is relatively slow in the immature leg muscles, in which extensive deposits are still found 24 hr after birth and, to some extent, persist until the 3rd day. In the more differentiated psoas muscle and especially in the diaphragm, the glycogen stores are completely mobilized already during the early hours. Section of the sciatic nerve 3 days before birth or within the first 2 hr after delivery does not affect glycogen depletion in the leg muscles. Neonatal glycogenolysis in rat muscle fibers takes place largely by segregation and digestion of glycogen particles in autophagic vacuoles. These vacuoles: (a) are not seen in fetal muscle fibers or at later postnatal stages, but appear concomitantly with the process of glycogen depletion and disappear shortly afterwards; (b) are prematurely formed in skeletal muscles of fetuses at term treated with glucagon; (c) contain almost exclusively glycogen particles and no other recognizable cell constituents; (d) have a double or, more often, single limiting membrane and originate apparently from flattened sacs sequestering glycogen masses; (e) are generally found to contain reaction product in preparations incubated from demonstration of acid phosphatase activity. The findings emphasize the role of the lysosomal system in the physiological process of postnatal glycogen mobilization and appear relevant in the interpretation of type II glycogen storage disease. PMID- 4331302 TI - Evaluation of serum acid phosphatase study in kidney diseases. PMID- 4331303 TI - Electron spin resonance spectrometry on the whole mouse in vivo: optimum frequency considerations. PMID- 4331301 TI - Change in the structure of Shope papilloma virus-induced arginase associated with mutation of the virus. AB - The change in the state of the virus-induced enzyme associated with a mutation in the virus provides additional evidence that the enzyme is synthesized from virus rather than rabbit genetic information. This change in structure results in differences in stability of polymerization, degree of optical rotary dispersion (ORD) specific rotation, change in elution characteristics from carboxymethyl cellulose, and a reduction in specific activity of the arginase. Liver arginase differs markedly in ORD characteristics from the virus-induced enzyme. In contrast to the virus-induced enzyme, it showed no negative Cotton effect at 233 nm until it was activated with manganese. Manganese had no influence on the ORD spectrum of virus-induced arginase. In addition, liver arginase is denatured by 4 M urea, while the virus-induced enzyme requires 10 M urea for denaturation. PMID- 4331304 TI - Surgical treatment of mediastinal tumors: a 40 year experience. PMID- 4331305 TI - Squamous cell carcinoma of skin in a rhesus monkey (Macaca mulatta): Report of a case. PMID- 4331306 TI - [Atypical poliovirus infections]. PMID- 4331307 TI - The development of the electroencephalogram in normal children from the age of 1 through 15 years. 14 and 6 Hz positive spike phenomenon. PMID- 4331308 TI - The anti-curare action of sodium fluoride at the neuromuscular junction of cat tenuissimus muscle. PMID- 4331309 TI - Penetration of angiotensin II into the brain. PMID- 4331310 TI - The action of isoprenaline on the superior cervical ganglion of the cat. PMID- 4331311 TI - [Anatomoclinical study of an extradural angiolipoma associated with an intramedullary glioblastoma]. PMID- 4331312 TI - [Symptomatic amnesic attack in glioblastoma involving the trigone]. PMID- 4331313 TI - Cycl AMP--and the Nobel Prize. PMID- 4331314 TI - Synthesis of steroids containing the -keto acid side-chain. PMID- 4331315 TI - Separation of free and bound steroid in the competitive protein binding assay for testosterone: accuracy and reproducibility. PMID- 4331317 TI - A new gas vacuolated heterotrophic rod from freshwaters. PMID- 4331316 TI - Biochemistry of synaptic inhibition at the cellular level: the GABA system. PMID- 4331318 TI - Some physical approaches to the structure of serum high-density lipoproteins. PMID- 4331319 TI - The mechanism of removal of lipoprotein triglyceride from the plasma. PMID- 4331320 TI - A latent collagenase released by bone and skin explants in culture. PMID- 4331321 TI - Control of histone modification within chromatin by adenine nucleotides and steroid hormones. PMID- 4331323 TI - Properties of pyruvate dehydrogenase from fat-cell mitochondria and its hormonal control. PMID- 4331322 TI - Effects of insulin and adrenaline on rat epididymal-fat-pad pyruvate dehydrogenase. PMID- 4331324 TI - The action of pyruvate on ethanol oxidation by intact isolated liver cells. PMID- 4331325 TI - Rapid oxidation of chondroitin sulphates and other glycols by periodic acid in organic solvents. PMID- 4331326 TI - Effects of glucose and other modifiers of insulin release on the oxidative metabolism of amino acids in micro-dissected pancreatic islets. AB - The oxidation of alanine, arginine, leucine, glucose, and pyruvate was studied in microdissected pancreatic islets of obese-hyperglycaemic mice. The following main observations were made. The oxidation of glucose was enhanced severalfold when its concentration was raised from 3 to 20mm. At the latter concentration the rate was about 65mmol/h per kg dry wt. The oxidation of 17mm-pyruvate amounted to 20mmol/h per kg dry wt. indicating a significant entry of this compound into the beta-cells. Leucine oxidation was little affected by concentration changes above 5mm, the rate at 20mm corresponding to about 25% of that obtained with 20mm glucose. In the absence of glucose, the oxidation of alanine or arginine was barely significant. Glucose stimulated the oxidation of alanine but depressed that of leucine. These effects of glucose were blocked by mannoheptulose or iodoacetamide but were not influenced by adrenaline, diazoxide, dibutyryl 3':5' cyclic AMP, or glibenclamide. The rate of alanine oxidation was doubled in the presence of 17mm-pyruvate but was unaffected by citrate or succinate. Succinate depressed the oxidation of leucine. Neither alanine nor leucine significantly affected the oxidation of glucose. It is suggested that the effects of glucose on the oxidation of alanine and leucine were mediated by metabolism of the sugar, and that amino acids do not act as insulin secretagogues by serving as fuels for the beta-cells. The results are consistent with the existence of mechanisms auxiliary to glucose metabolism for control of insulin release. PMID- 4331327 TI - The regulation of rat liver L-alanine-glyoxylate aminotransferase by glucagon in vivo. PMID- 4331328 TI - [Mitochondriogenesis analyzed by blocks on mitochondrial translation and transcription]. PMID- 4331329 TI - Characterization and partial purification of the specific glucocorticoid-binding component from mouse fibroblasts. PMID- 4331330 TI - The zymogen of tadpole collagenase. PMID- 4331331 TI - Ionic strength dependent dissociation and association of yeast uridine diphosphate galactose 4-epimerase subunits. PMID- 4331332 TI - Selective adsorption of bis(1-anilino-8-naphthalenesulfonate) to the multiple forms of lactic dehydrogenase. PMID- 4331333 TI - Proline-rich proteins from human parotid saliva. I. Isolation and partial characterization. PMID- 4331334 TI - Synthesis of 3',5'-dinucleoside diphosphates with ribonuclease T 1 . PMID- 4331335 TI - Resistance of uridine 5'-fluorophosphate to alkaline phosphatase and its sensitivity to 5'-nucleotidase. PMID- 4331336 TI - The absence of a non-nucleotide linker in polyoma and phiX174 DNA. PMID- 4331338 TI - Osteodystrophy: biochemical defect in pseudohypoparathyroidism. PMID- 4331337 TI - DNA synthesis in normal and virus-transformed mammalian cells after methionine deprivation. PMID- 4331339 TI - Vitamin D metabolism and its relationship to familial hypophosphatemia. PMID- 4331340 TI - Hazards of colostomy closure. PMID- 4331341 TI - [Association of liver cirrhosis with amebic liver abscess and hepatoma]. PMID- 4331342 TI - [Quantitative and qualitative variations of plasma free fatty acids under the effect of an orally administered excess of lipids in normal humans]. PMID- 4331343 TI - Taurine excretion and the influence of drugs. PMID- 4331344 TI - Characterization of platelet alkaline phosphatase in normal subjects and in trisomy 21 Down's syndrome patients. PMID- 4331345 TI - Reduced nicotinamide adenine dinucleotide-coupled reaction for emergency blood urea estimation. PMID- 4331346 TI - [Prevention of rickets]. PMID- 4331348 TI - [Effect of skin stimuli on the electrical activity of tonic and phasic muscles]. PMID- 4331347 TI - Properties of the inferferon-like virus inhibitor released during interaction of mouse sensitized lymphocytes with their target cells. PMID- 4331349 TI - Proteolytic ulcers of cornea. Report of three cases. PMID- 4331350 TI - Activity of colistin against Pseudomonas aeruginosa: inhibition by calcium. PMID- 4331351 TI - Dual-channel scan with 198 Au colloidal gold and 75 Se sodium selenite for the diagnosis of neoplastic lesions of the liver. PMID- 4331352 TI - Analysis of phenylephrine and phenylpropanolamine hydrochlorides in combination. PMID- 4331353 TI - Kinetic demonstration of a metastable intermediate in isomerization of penicillin to penicillenic acid in aqueous solution. PMID- 4331354 TI - Effectiveness of inpatient follow-up care. PMID- 4331355 TI - [Jaundice caused by cytomegalic inclusion disease. Anatomo-clinical study]. PMID- 4331356 TI - Telepathy and dreams: a failure to replicate. PMID- 4331357 TI - Dream recall and short-term memory. PMID- 4331358 TI - Thresholds of auditory sensitivity and binaural localization during sleep. PMID- 4331359 TI - [Morphological-functional study of the bone marrow in 10 patients subjected to chronic thorium dioxide irradiation]. PMID- 4331360 TI - [Effect of sport participation on the frequency and duration of some diseases]. PMID- 4331361 TI - [Detection of latent exacerbation of chronic pneumonia by studying leukocyte alkaline phosphatase activity and the phosphatase index]. PMID- 4331362 TI - [Arrhenoblastoma of the ovary in a 15-year-old girl]. PMID- 4331363 TI - [Role of the cellular factor in transformation with SV40 virus]. PMID- 4331364 TI - [Effect of toluidine blue on the synthesis of highly polymerized nucleic acids in normal and poliovirus-infected KB cells]. PMID- 4331365 TI - [Epizootiology of Marek's disease in chickens]. PMID- 4331366 TI - [Polysyndactyly, short limbs, and genital malformations--a new syndrome?]. PMID- 4331368 TI - Hyphal structure in Fusarium oxysporum (Schlecht) revealed by freeze-etching. PMID- 4331367 TI - The adjustment of photosynthetically grown cells of Rhodospirillum rubrum to aerobic light conditions. PMID- 4331369 TI - [Action of synthetic estrogens on some hematochemical constants in cattle, with special reference to calcium, phosphorus, magnesium and citric acid]. PMID- 4331370 TI - A new form of N-acetyl-glucosaminidase present in pregnancy serum. PMID- 4331373 TI - Ultrastructural changes of the nucleoli during early development of fertilized rat eggs. PMID- 4331372 TI - Interaction of nitrite with mammalian mitochondrial cytochromes. PMID- 4331371 TI - Studies on the control of cholesterol biosynthesis: the adenosine 3':5'-cyclic monophosphate-dependent accumulation of a steroid carboxylic acid. PMID- 4331374 TI - Studies on the relation of decidual cell response to luteal maintenance in the pseudopregnant rat. PMID- 4331375 TI - The enzymically active unit of lactic dehydrogenase. Molecular properties of lactic dehydrogenase at low-protein and high salt concentrations. PMID- 4331376 TI - [Primary structure of bovine s1 casein. Complete sequence]. PMID- 4331377 TI - An improved technique for the analysis of ribonucleoprotein fragments from Escherichia coli 30S ribosomes. PMID- 4331378 TI - Inactivation of 50S ribosomal subunits by 2-methoxy-5-nitrotropone. PMID- 4331379 TI - Neurocutaneous herpes simplex. PMID- 4331380 TI - Active site spin-labeled -chymotrypsin. Guanidine hydrochloride denaturation studies using electron paramagnetic resonance and circular dichroism. PMID- 4331381 TI - The synthesis and some properties of a spin label analogue of adenosine 5' triphosphate. PMID- 4331382 TI - Studies on the role of adenosine 3',5'-monophosphate in the hepatic actions of glucagon and catecholamines. PMID- 4331383 TI - Interaction with phosphodiesterase of free and kinase-complexed cyclic adenosine 3',5'-monophosphate. PMID- 4331384 TI - The effects of 2 H 2 O on sodium plus potassium ion-stimulated adenosine triphosphatase of rat brain. PMID- 4331385 TI - Insulin-like effects of trypsin on fat cells. Localization of the metabolic steps and the cellular site affected by the enzyme. PMID- 4331386 TI - The fatty acid composition of individual phospholipids from rat liver nuclear membrane and nuclei. PMID- 4331387 TI - Resistance to catabolite repression of histidase and proline oxidase during nitrogen-limited growth of Klebsiella aerogenes. PMID- 4331388 TI - Splitting of the ribose-ribose linkage of poly(adenosine diphosphate-robose) by a calf thymus extract. PMID- 4331389 TI - An adenosine 3',5'-monophosphate-inhibited protein kinase from Physarum polycephalum. PMID- 4331390 TI - Curable renal hypertension--renin, marker or cause? PMID- 4331392 TI - [Pyrophosphate synovitis]. PMID- 4331391 TI - [Effect of some antirheumatic agents on the gastric mucous membrane]. PMID- 4331393 TI - Adenoviral infection in suckling Arabian foals. PMID- 4331395 TI - [Immunodepressive treatment of rheumatoid polyarthritis]. PMID- 4331396 TI - [Identification and biological properties of bovine-type herpesvirus]. PMID- 4331397 TI - [Pathomorphological changes in para-influenza of cattle]. PMID- 4331398 TI - [Prevention of anaerobic enterotoxemia of swine]. PMID- 4331399 TI - [Experimental reproduction of Rous sarcoma]. PMID- 4331400 TI - [Ultrastructure of invertebrate hemocytes. VI. Hemocytes of Psammechinus miliaris (Echinoidea)]. PMID- 4331401 TI - Sleep in the cat: a parallel increase of deep slow wave sleep and REM sleep following total sleep deprivation. PMID- 4331402 TI - Function of single interneurones established by their monosynaptic inhibitory effects on motoneurones. PMID- 4331403 TI - Repetitive impulse firing: properties of a neurone model based on "voltage clamp equations" compared to the properties of spinal motoneurones. PMID- 4331404 TI - Arteriography of Wilms' tumor. PMID- 4331405 TI - The periosteum of the mandible and intraoral carcinoma. PMID- 4331406 TI - Soft part sarcomas of the head and neck. PMID- 4331407 TI - Primary orbital tumors. PMID- 4331408 TI - Surgical management of intravascular glomus jugulare tumor. PMID- 4331409 TI - Adenoid cystic carcinoma of major and minor salivary glands. PMID- 4331410 TI - [Wilm's tumor with multiple cavities]. PMID- 4331411 TI - [Ultrastructural aspects of virus-like inclusions in the skin of Lupus erythematosus acutus and chronicus]. PMID- 4331412 TI - Viruses and breast cancer. Introductory remarks. PMID- 4331414 TI - Mammographic diagnosis of minimal breast cancer. PMID- 4331415 TI - The pathologist's role in minimal breast cancer. PMID- 4331416 TI - The problem of multiple lesions of the breast. PMID- 4331417 TI - Radiography of breast specimens. PMID- 4331418 TI - Indications for castration and adrenalectomy for advanced breast cancer. PMID- 4331419 TI - Effects of isometric exercise on cardiac performance. The grip test. PMID- 4331420 TI - Periodic acid as a new oxidant for the degradation of bile pigments. Isolation of a biliverdine type of reaction intermediate on oxidation of bilirubin with periodic acid. PMID- 4331421 TI - Liver damage by protracted ethanol uptake and its reversibility. PMID- 4331422 TI - Antagonism of dibutyryl-Guo-3':5'-P and atropine on stomach smooth muscle contraction. PMID- 4331424 TI - Antimicrobial activity of cyclacillin against Escherichia coli in vivo and in vitro. PMID- 4331423 TI - Effects of some membrane-active and other compounds on thrombin-induced platelet aggregation. PMID- 4331425 TI - [Seasonal changes in the enzyme pattern and neurosecretion content as well as innervation of the preoptic nucleus in the brook trout (Salmo trutta fario) with special reference to the hypothalamic hydrencephalokrinia]. PMID- 4331426 TI - [Effect of ACTH on the concentrations of alpha amino nitrogen, amino acid and protein secretion in rat endometrium]. PMID- 4331427 TI - Glomus tumour in the fingers. PMID- 4331428 TI - Osteoid osteoma of the fingers. PMID- 4331429 TI - Genetics and malformations of the hand. PMID- 4331430 TI - Pollicisation in children. PMID- 4331431 TI - Sensitization of Escherichia coli K-12 to gamma-rays by niacin deprivation. PMID- 4331433 TI - Structural analysis of nucleolar precursors of ribosomal ribonucleic acids. II. Polypurine sequences as chemical markers of processing of nucleolar 45 S ribonucleic acid. PMID- 4331434 TI - Adenohypophyseal secretory granules. I. Their phosphorylation and association with protein kinase. PMID- 4331435 TI - Sulfheme proteins. II. The reversible oxygenation of ferrous sulfmyoglobin. PMID- 4331436 TI - Amygdaloid modulation of sodium chloride and water intake in the rat. PMID- 4331437 TI - Evaluation of rigid prosthetic rings as in vivo intravascular thrombogenic models. PMID- 4331438 TI - [Effects of some drugs on mobilization of transmitter substances in neuromuscular junction]. PMID- 4331439 TI - [Mechanism of neuromuscular transmission. 4. Relationship between respiratory muscles and 2 kinds of skeletal muscles on the development of phase II block induced by succinylcholine]. PMID- 4331440 TI - [Case of multiple cancer of 5 different locations discovered independently in the period of 10 years--scapular sarcoma and cancer of the sigmoid, right kidney, appendix and lung]. PMID- 4331441 TI - Epidemiologic significance of Klebsiella pneumoniae. A 3-month study. PMID- 4331442 TI - Are noradrenaline excitations artefacts? PMID- 4331444 TI - Diazepam and presynaptic inhibition. PMID- 4331443 TI - Ionic requirements for the neuromuscular blocking action of botulinum toxin: implications with regard to synaptic transmission. PMID- 4331445 TI - Effects of phenothiazine tranquilizers on the cyclic 3',5'-adenosine monophosphate system of rat brain. PMID- 4331446 TI - A neuropsychopharmacological comparison of d-amphetamine, L-dopa and cocaine. PMID- 4331447 TI - [Circulatory collapse, oliguria and edema of the lower extremities in an aged woman]. PMID- 4331448 TI - [Effect differences between angiotensin II and noradrenalin in reference to diuresis, sodium and potassium excretion in healthy persons and patients with kidney diseases]. PMID- 4331449 TI - [Oral immunization against pox. 1. Studies on oral vaccination against fowl pox with the attenuated H strain HP-1]. PMID- 4331450 TI - [Single outbreaks of foot and mouth disease in the Federal Republic of Germany in 1970]. PMID- 4331451 TI - [Occurrence of parainfluenza 1-virus (Sendai-virus) infection in an experimental rat colony]. PMID- 4331452 TI - Factors influencing the accumulation of cyclic AMP in brain tissue. PMID- 4331453 TI - On the development and properties of the brain adenyl cyclase system. PMID- 4331455 TI - Prostaglandins and cyclic AMP. PMID- 4331454 TI - Effect of membrane depolarization and biogenic amines on the formation of cyclic AMP in incubated brain slices. PMID- 4331456 TI - Cyclic 3',5' -adenosine monophosphate and the effects of hormones on hormone sensitive lipase from adipose tissue. PMID- 4331457 TI - Neural and hormonal regulation of pineal adenyl cyclase activity. PMID- 4331458 TI - Pineal gland: stimulation of melatonin production by norepinephrine involves cyclic AMP-mediated stimulation of N-acetyltransferase. PMID- 4331459 TI - The receptor protein for cyclic AMP in the control of glycogenolysis. PMID- 4331460 TI - On the mechanism of action of cyclic AMP. PMID- 4331461 TI - Synthesis and degradation of cyclic 3',5'-adenosine monophosphate in frog erythrocytes. PMID- 4331462 TI - Cyclic AMP and transmission at the neuromuscular junction. PMID- 4331463 TI - Possible cyclic AMP-mediated adrenergic synapses to rat cerebellar Purkinje cells: combined structural, physiological, and pharmacological analyses. PMID- 4331464 TI - Behavioral and vegetative effects produced by dibutyryl cyclic AMP injected into different areas of the brain. PMID- 4331465 TI - Cyclic nucleotide phosphodiesterase. PMID- 4331466 TI - A role of cyclic nucleotides in brain metabolism. PMID- 4331467 TI - The measurement of cyclic nucleotides by radioimmunoassay. PMID- 4331468 TI - Axial tomography of optic canals in diagnosis of children's eye and optic nerve defects. PMID- 4331469 TI - Isolation of stromal collagenase in corneal inflammation. PMID- 4331471 TI - Phosphoglycolate production catalyzed by ribulose diphosphate carboxylase. PMID- 4331470 TI - Local corticosteroid therapy and reactivation of herpetic keratitis. PMID- 4331472 TI - Protein synthesis directed by encephalomyocarditis virus RNA. II. The in vitro synthesis of high molecular weight proteins and elements of the viral capsid. PMID- 4331473 TI - Chemical synthesis of the reduced form of an intermolecular crosslink of collagen: a re-evaluation of the structure of syndesine. PMID- 4331474 TI - 35 C1 NMR studies of the active site zinc of horse liver alcohol dehydrogenase. PMID- 4331475 TI - Inhibition of liver microsomal pyrophosphatase by free fatty acids. PMID- 4331476 TI - Characterization of two adenosine 3',5'-monophosphate-dependent protein kinases from rat liver. PMID- 4331477 TI - Asymmetry in the hydroxylation of (Pro-Pro-Gly) 5 by protocollagen proline hydroxylase. PMID- 4331478 TI - The role of the reduced diphosphopyridine nucleotide in the reactivation of dogfish muscle lactate dehydrogenase. PMID- 4331479 TI - Demonstration of a specific -bungarotoxin binding component in electrophorus electricus electroplax membranes. PMID- 4331480 TI - Antibodies against tumours. PMID- 4331481 TI - Terrors of sleep. PMID- 4331482 TI - Tumors of muscles and synovial tissues. PMID- 4331483 TI - Role of the pressor action of angiotensin II in experimental hypertension. PMID- 4331484 TI - Mechanism of pulmonary conversion of angiotensin I to angiotensin II in the dog. PMID- 4331485 TI - Impulse propagation in the mammalian atrium. PMID- 4331486 TI - [Neuroblastoma sympathicum from the morphological viewpoint]. PMID- 4331487 TI - Ontogenesis of the pituitary-adrenal axis in the chick embryo. PMID- 4331488 TI - Examination of angiotensin-like substances from renal and extrarenal sources in mammalian and nonmammalian species. PMID- 4331489 TI - [Subcellular distribution and activity of cytidinemonophospho-N-acetylneuraminate synthetase in the young rat brain]. PMID- 4331490 TI - Studies on the partial degradation of polyunsaturated fatty acids in subcellular fractions of rat liver. PMID- 4331491 TI - Metabolism of isolated kidney tubules. Oxygen consumption, gluconeogenesis and the effect of cyclic nucleotides in tubules from starved rats. PMID- 4331492 TI - Biochemical analysis of the pinocytotic process. 3. Subcellular distribution and metabolic effects of ( 3 H)Triton WR-1339. PMID- 4331494 TI - [Chromophore substrates. 3. An improved method for the preparation of the colored colagenase substrate 4-phenylazobenzyl-oxycarbonyl-L-propyl-L-leucyl-glycyl-L propyl-D-arginine]. PMID- 4331493 TI - [Specific incorporation of the coenzyme analogue nicotinamide-(5-(bromoacetyl)-4 methyl-imidazole)-dinucleotide into alcohol dehydrogenase from liver]. PMID- 4331495 TI - The effect of streptozotocin on the fine structure of the beta cell of the cod pancreas. PMID- 4331496 TI - Stimulation by growth hormone of deoxyribonucleic acid synthesis and proliferation of rat thymic lymphocytes. PMID- 4331497 TI - Lymphocyte-retrobulbar fibroblast interaction: mechanisms by which stimulation occurs and inhibition of stimulation. PMID- 4331498 TI - Changes in terminal respiratory pathways of Bacillus subtilis during germination, outgrowth and vegetative growth. AB - The chemical and enzymatic properties of the cytochrome system in the particulate preparations obtained from dormant spores, germinated spores, young vegetative cells, and vegetative cells of Bacillus subtilis PCI219 were investigated. Difference spectra of particulate fractions from dormant spores of this strain suggested the presence of cytochromes a, a(3), b, c(+c(1)), and o. All of the cytochrome components were present in dormant spores and in germinated spores and vegetative cells at all stages which were investigated. Concentrations of cytochromes a, a(3), b, and c(+c(1)) increased during germination, outgrowth, and vegetative growth, but that of cytochrome o was highest in dormant spores. As the cytochrome components were reducible by reduced nicotinamide adenine dinucleotide (NADH), they were believed to be metabolically active. Difference spectra of whole-cell suspensions of dormant spores and vegetative cells were coincident with those of the particulate fractions. NADH oxidase and cytochrome c oxidase were present in dormant spores, germinated spores, and vegetative cells at all stages after germination, but succinate cytochrome c reductase was not present in dormant spores. Cytochrome c oxidase and succinate cytochrome c reductase activities increased with growth, but NADH oxidase activity was highest in germinated spores and lowest in vegetative cells. There was no striking difference between the effects of respiratory inhibitors on NADH oxidase in dormant spores and those on NADH oxidase in vegetative cells. PMID- 4331500 TI - Evidence for distinct kynureninase and hydroxykynureninase activities in Neurospora crassa. AB - Previous studies have indicated that a single enzyme, "kynureninase," catalyzes the reactions of l-kynurenine to anthranilate and l-3-hydroxykynurenine to 3 hydroxyanthranilate in Neurospora crassa and in other organisms. The present report describes separate enzymes which catalyze these reactions in N. crassa. The first, a kynureninase, preferentially catalyzes kynurenine to anthranilate and is induced over 400-fold by tryptophan or a catabolite of tryptophan. The second, a hydroxykynureninase, is constitutive or noninducible by tryptophan and preferentially catalyzes l-3-hydroxykynurenine to 3-hydroxyanthranilate. The physiological significance of these enzymes may be inferred from the facts that (i) the noninducible enzyme hydroxykynureninase appears to be the main enzyme present in uninduced cells that is capable of catalyzing l-3-hydroxykynurenine to 3-hydroxyanthranilate for the indispensible synthesis of nicotinamide adenine dinucleotide, and (ii) the inducible enzyme kynureninase is induced by tryptophan to a concentration far in excess of that needed to meet the requirements of the cells for nicotinamide adenine dinucleotide, resulting in the excretion of anthranilate into the medium. PMID- 4331499 TI - Physiology of sporeforming bacteria associated with insects. IV. Glucose catabolism in Bacillus larvae. AB - Bacillus larvae appears to be unique among related bacilli in that it contains enzymes of the Embden-Meyerhof-Parnas, pentose phosphate, and Entner-Doudoroff pathways. Simultaneous occurrence of enzymes of all three metabolic pathways has not until now been reported in other Bacillus species. Radiorespirometric analyses of specifically labeled glucose catabolism reveal that vegetative cells of B. larvae dissimilate glucose predominately via a direct oxidative route and to a lesser extent by a nonoxidative scheme although specific activities of enzymes of all three pathways are comparable. Predominance of an oxidative pathway is unusual and also has not been reported for other bacilli. Studies on the oxidation of pyruvic, acetic, succinic, and alpha-ketoglutaric acids show that terminal respiration of cells in transition from vegetative growth to sporulation involves both the tricarboxylic acid and glyoxylic acid cycles. The relationship of these findings to the fastidiousness and oligosporogeny of B. larvae is discussed. PMID- 4331501 TI - Respiration and protein synthesis in Escherichia coli membrane-envelope fragments. V. On the reduction of nonheme iron and the cytochromes by nicotinamide adenine dinucleotide and succinate. AB - The sensitivity of nicotinamide adenine dinucleotide (NADH) oxidase and succinoxidase to metal chelators, the generation of an electron paramagnetic resonance (EPR) signal upon addition of these substrates, and the rate of formation of the EPR signal relative to the rate of the cytochrome reduction suggest the participation of nonheme iron proteins in the respiratory process of Escherichia coli. The most inhibitory metal chelator, thenoyltrifluoro acetone, inhibited the reduction of nonheme iron and cytochromes but did not prevent the reoxidation of the reduced forms. The EPR signal, dehydrogenase, and oxidase activities evoked by NADH are considerably greater than the corresponding activities evoked by succinate. Because both substrates can reduce almost all of the cytochromes, a model in which fewer succinate dehydrogenase-nonheme iron protein complexes are linked to a common cytochrome chain than NADH dehydrogenase nonheme iron protein complexes is considered likely. PMID- 4331502 TI - pH and population density in the regulation of animal cell multiplication. AB - Sparse and dense cultures of chick embryo cells were affected differently by pH. The rates of cell multiplication and of thymidine-(3)H incorporation into DNA of dense cultures were increased as the pH was increased from 6.6 to 7.6. At pH higher than 7.6 the rate of multiplication decreased slightly in the dense cultures, but the rate of thymidine-(3)H incorporation continued to increase. The discrepancy was due in part to cell death and detachment at very high pH, and in part to a more rapid uptake of thymidine-(3)H at very high pH. Sparse cultures were much less sensitive to pH reduction and, when a suitably conditioned medium was used to minimize cell damage, very sparse cultures grew almost as well at pH 6.7 as at higher pH. The rates of cell multiplication and thymidine-(3)H incorporation at low pH decreased in the initially sparse cultures before they reached confluent cell densities. There was no microscope evidence of direct contact between plasma membranes of cells at these densities although the parallel orientation indicated that the cells were influencing locally each other's behavior. Even at much higher cell densities, electron microscopy revealed large intercellular gaps partly filled with a fragmentary electron opaque material suspected to be glycoprotein. Wounding experiments showed that pH affected cell migration in a manner similar to its effects on cell multiplication. Low pH inhibited cell migration, but those cells which migrated into the denuded region multiplied as rapidly at low pH as at high pH. The effects of pH on growth were correlated with effects on the uptake of 2 deoxyglucose-(3)H. Dense populations of cells inhibited by low pH were stimulated to incorporate thymidine-(3)H by the addition of small amounts of diethylaminoethyl-dextran. Rous sarcoma cells at high cell density were less sensitive to pH than were normal cells at the same density, but were more sensitive than sparse normal cultures. The results suggest that cell growth is inhibited through the combined effects of both lowered pH and high cell density on cell surface permeability. PMID- 4331503 TI - Sarcoplasmic reticulum and the temperature-dependent contraction of smooth muscle in calcium-free solutions. AB - The contractile response of turtle oviduct smooth muscle to acetylcholine after 30 min of incubation of muscles in Ca-free, 4 mM ethylene (bis) oxyethylenenitrilotetraacetic acid (EGTA) solutions at room temperature was greater than the contractile response after 30 min of incubation in the Ca-free medium at 37 degrees C. Incubation in Ca-free solution at 37 degrees C before stimulation with acetylcholine in Ca-free solutions at room temperature also reduced the contractile response, suggesting that activator calcium was lost from the fibers at a faster rate at higher temperatures. Electron micrographs of turtle oviduct smooth muscle revealed a sarcoplasmic reticulum (SR) occupying approximately 4% of the nucleus- and mitochondria-free cell volume. Incubation of oviduct smooth muscle with ferritin confirmed that the predominantly longitudinally oriented structures described as the SR did not communicate with the extracellular space. The SR formed fenestrations about the surface vesicles, and formed close contacts (couplings) with the surface membrane and surface vesicles in oviduct and vena caval smooth muscle; it is suggested that these are sites of electromechanical coupling. Calculation of the calcium requirements for smooth muscle contraction suggest that the amount of SR observed in the oviduct smooth muscle could supply the activator calcium for the contractions observed in Ca-free solutions. Incubation of oviduct smooth muscle in hypertonic solutions increased the electron opacity of the fibers. A new feature of some of the surface vesicles observed in oviduct, vena caval, and aortic smooth muscle was the presence of approximately 10 nm striations running approximately parallel to the openings of the vesicles to the extracellular space. Thick, thin, and intermediate filaments were observed in turtle oviduct smooth muscle, although the number of thick filaments seen in the present study appeared less than that previously found in mammalian smooth muscles. PMID- 4331504 TI - Passage of fucose- 3 H label from the Golgi apparatus into dense and multivesicular bodies in the duodenal columnar cells and hepatocytes of the rat. PMID- 4331506 TI - Use of ceric sulfate and cupric perchlorate for titrimetric analyses of phenothiazine derivatives. PMID- 4331507 TI - [Results in the surgical treatment of bronchial carcinoma]. PMID- 4331505 TI - Membrane-to-membrane cross-bridges. A means to orientation and interaction of membrane faces. PMID- 4331508 TI - Release of renin by human kidney slices, in vitro effect of angiotensin II, norepinephrine and aldosterone. PMID- 4331509 TI - [The activity of certain enzymes (catalase, ATP-ase and PP-ase) in chronic physical effort in rats treated with thyroid hormones]. PMID- 4331510 TI - The diagnosis of atypical varicella. PMID- 4331511 TI - [Research on the spread of some enteric viruses in urban areas]. PMID- 4331512 TI - [Further data on genetic markers in polioviruses]. PMID- 4331513 TI - A decade of experience with electronic simulation of the micturition reflex. PMID- 4331514 TI - Cancer chemotherapy in urology. PMID- 4331515 TI - [Role of respiratory viral infections in the development of exacerbations in protracted and chronic respiratory diseases in children]. PMID- 4331516 TI - Studies on the herpes-type recovered from the Burkitt's tumor and other human lymphomas. PMID- 4331517 TI - Objective diagnosis (ulnar nerve conduction velocity) and current therapy of the thoracic outlet syndrome. PMID- 4331519 TI - [Study of the active center of myosin by the spin label method]. PMID- 4331518 TI - The metabolism of phosphatidylinositol in the thyroid gland of the pig. AB - 1. The metabolism of phosphatidylinositol in pig thyroid has been investigated as a basis for understanding the specific stimulation of the synthesis of this phospholipid in the gland by thyrotropin. 2. The gland contained an active Ca(2+) dependent phosphatidylinositol-splitting enzyme with an optimum pH of 5.3-5.5. 3. The major water-soluble product (65%) formed by this catabolic enzyme was not phosphorylinositol but a related compound, which may be a cyclic phosphorylinositol. Both this and phosphorylinositol (35%) were released simultaneously from the phosphatidylinositol substrate. 4. The phosphatidylinositol-splitting enzyme was found almost exclusively in the supernatant fraction obtained by homogenization of the gland. It was not present in the acid-phosphatase-containing particulate fraction. 5. The incorporation of [2-(3)H(1)]inositol into phosphatidylinositol in the presence of either CDP diglyceride or CTP+ATP was most active in the microsomal fraction. 6. When thyroidal microsomes were labelled with [(3)H]inositol and (32)P, and then incubated with unlabelled inositol, there was a dramatic loss of (3)H labelling from the phosphatidylinositol, which was not accompanied by an equivalent loss of (32)P from the phosphate moiety. This turnover of the inositol moiety required nucleotide coenzymes. It is postulated that the phosphatidylinositol is split into inositol and a phosphorus-containing lipid precursor of the phospholipid that remains on the microsomal membrane and is recycled. 7. Isolated thyroidal mitochondria synthesized phosphatidylinositol from [2-(3)H(1)]inositol only because of their contaminating microsomal component. 8. Some evidence has been obtained of a rapid transfer of phosphatidylinositol molecules from thyroidal microsomes to mitochondria when these were incubated together in the presence of a supernatant fraction. 9. Both phosphatidylinositol breakdown by the supernatant fraction of the gland and synthesis by the microsomes were totally inhibited by 1mm-chlorpromazine. This drug is known to suppress thyrotrophin-induced stimulation of activity in thyroid slices. PMID- 4331520 TI - [Daily fluctuations in the concentration of paramagnetic centers in normal mouse liver]. PMID- 4331522 TI - Reconstruction of synaptic geometry and neural connections from serial thick sections examined by the medium high voltage electron microscope. PMID- 4331521 TI - [Complexes with charge transfer of some aminoazo compounds with nucleic acid components]. PMID- 4331523 TI - [Integration of dopamine in aminergic endings of the meta-adenohypophysis of the sticklebach (Gasterosteus aculeatus L.)]. PMID- 4331524 TI - [Effect of trypaflavine on the reproduction and submicroscopic organization of Crithidia oncopelti (during cultivation in conditions of active aeration)]. PMID- 4331525 TI - [Diagnosis and differential diagnosis of congenital androgenital syndrome using ACTH test]. PMID- 4331527 TI - [Deoxyribonucleic acids of Acetobularia mediterranea]. PMID- 4331526 TI - The kinetics of pig brain aldehyde dehydrogenase. PMID- 4331528 TI - The liaison nurse. PMID- 4331529 TI - Inhibition in the auditory nerve? PMID- 4331530 TI - The effect of prolactin on blood pressure, blood volume, and angiotensin response. PMID- 4331531 TI - Angiotensin binding by receptor-like factors in plasma from seriously ill patients and an experimental dog model. PMID- 4331532 TI - Essential hypertension: evidence for altered activity of cortisol-metabolizing enzymes. PMID- 4331534 TI - Demonstration and properties of a soluble cAMP binding protein in bovine endometrium. PMID- 4331533 TI - Adrenergic control of hormone secretion. PMID- 4331535 TI - Cyclic AMP and gastric secretion. PMID- 4331536 TI - A comparison of human lymphocyte stimulation by cyclic AMP, GMP, and related compounds. PMID- 4331538 TI - A re-evaluation of the concept of "non-specificity" in stress theory. PMID- 4331537 TI - [Melanotic tumor of the pineal region]. PMID- 4331539 TI - The new biology of sleep. PMID- 4331540 TI - [Malignant glomus tumors of the stomach]. PMID- 4331541 TI - [Diagnosis and treatment of neurogenic tumors of the neck]. PMID- 4331542 TI - [Surgical treatment of neurogenic mediastinal tumors]. PMID- 4331543 TI - Diagnosis and treatment of urinary tract infections. PMID- 4331544 TI - Renal regulation of sodium excretion. PMID- 4331545 TI - [Pruritus, jaundice and weight loss]. PMID- 4331546 TI - Hormonal response of glycolytic key enzymes of erythrocytes in insulinoma. PMID- 4331547 TI - Specific RNA methylase associated with avian myeloblastosis virus. PMID- 4331548 TI - Effect of steroids and dibutyryl cyclic AMP on the sensitivity of haemopoietic stem cells to 3 H-thymidine in vitro. PMID- 4331549 TI - Cell-free transmission of mouse neuroblastoma. PMID- 4331550 TI - Taurine--a possible neurotransmitter? PMID- 4331551 TI - Induction of growth in newt and frog limbs after perfusion with extracts from newt blastemas. PMID- 4331552 TI - In vivo role of the UV-endonuclease from Micrococcus luteus in the repair of DNA. PMID- 4331553 TI - New inhibitor of phosphodiesterase with anti-bronchoconstrictor properties. PMID- 4331555 TI - Endogenous prostaglandins modulate lipolytic processes in adipose tissue. PMID- 4331554 TI - Presence of sarcoma genome in a "non-infectious" mammalian virus. PMID- 4331556 TI - Orthostatic hypotension and the renin-angiotensin system in paraplegia. PMID- 4331557 TI - Neurohypophyseal hormone-responsive adenylate cyclase from mammalian kidney. AB - The investigation was undertaken to evaluate the direct stimulatory effects of neurohypophyseal hormones upon adenylate cyclase activity in a cell-free, particulate fraction derived from the kidney medulla of various mammalian species. The relative affinity of neurohypophyseal hormones for the receptor component of the adenylate cyclase system (as defined by the concentration of hormone required for half-maximal stimulation) had the order [8-arginine] vasopressin > [8-lysine]-vasopressin >> oxytocin (AVP > LVP >> OT) for rat, mouse, rabbit, and ox; in the pig, the order was LVP > AVP >> OT. The relative affinities of the three hormones in rat and pig cyclase systems were found to correspond with the relative antidiuretic potencies of these hormones in the intact rat and pig. These findings show that the renal receptor for neurohypophyseal hormones in a particular species exhibits the highest affinity for the specific antidiuretic hormone that occurs naturally in that species. Some of the molecular requirements for the stimulation of rabbit adenylate cyclase were defined by studies of several neurohypophyseal analogs possessing structural changes in positions 1, 2, 3, 4, 5, 8, and 9. This investigation introduces the particulate preparation of renal medullary adenylate cyclase as a tool for the analysis of neurohypophyseal hormone-receptor interactions and indicates that this preparation can be adapted to serve as an in vitro bioassay system for antidiuretic hormonal activity. PMID- 4331558 TI - Inhibition by siomycin and thiostrepton of both aminoacyl-tRNA and factor G binding to ribosomes. AB - Siomycin, a peptide antibiotic that interacts with the 50S ribosomal subunit and inhibits binding of factor G, is shown also to inhibit binding of aminoacyl-tRNA; however, it does not impair binding of fMet-tRNA and completion of the initiation complex. Moreover, unlike other inhibitors of aminoacyl-tRNA binding (tetracycline, sparsomycin, and streptogramin A), siomycin completely abolishes the GTPase activity associated with the binding of aminoacyl-tRNA catalyzed by factor T(u). A single-site interaction of siomycin appears to be responsible for its effect on both the binding of the aminoacyl-tRNA-T(u)-GTP complex and that of factor G. PMID- 4331559 TI - Photo-affinity labels for adenosine 3':5'-cyclic monophosphate. AB - Three derivatives of cyclic AMP that are potentially useful as photo-affinity labels were synthesized. One of these derivatives is, upon photolysis, specifically incorporated into the cyclic AMP-binding site of rabbit muscle phosphofructokinase. The use of these derivatives in isolating and identifying cyclic AMP receptor sites is discussed. PMID- 4331560 TI - Mechanism of initiation and repression of in vitro transcription of the lac operon of Escherichia coli. AB - A cyclic AMP-binding protein (CAP protein), cyclic AMP, and RNA polymerase holoenzyme are shown to initiate lac transcription at the lac promoter. Lac repressor appears to control transcription by preventing RNA polymerase and/or CAP protein from binding to the lac promoter. Results support the idea that the lac promoter is composed of two sites that interact with CAP protein and RNA polymerase holoenzyme. The promoter can be altered by mutation so that holoenzyme alone can initiate lac transcription correctly. PMID- 4331561 TI - Insulin receptors in the liver: specific binding of ( 125 I)insulin to the plasma membrane and its relation to insulin bioactivity. AB - With [(125)I]insulin at 7 x 10(-10) M, 25% of the radioactivity was bound to plasma membranes purified from rat liver. 20% of the [(125)I]insulin binding was inhibited by unlabeled insulin at 10(-9) M (6 ng/ml), equivalent to insulin concentrations in hepatic portal blood; inhibition of [(125)I]insulin binding was 80% at 10(-7) M and 90% at 10(-5) M. Eight insulins and derivatives with biological potencies that differed over a 100-fold range inhibited the binding of [(125)I]insulin to liver membranes in direct proportion to their ability to stimulate glucose oxidation in isolated fat cells. Inactive insulin chains, as well as glucagon, ACTH, and human growth harmone were without effect. The binding of [(125)I]insulin increased 55-fold as plasma membrane was purified from crude homogenate. Binding was time- and temperature-dependent, and addition of excess insulin produced rapid dissociation of [(125)I]insulin. This study demonstrates directly the binding of insulin to its biologically important receptors. PMID- 4331562 TI - Cytoplasmic DNA synthesis induced by RNA tumor viruses. AB - Infection of mouse embryo cells with two strains of murine sarcoma virus and one strain of murine leukemia virus was followed rapidly by synthesis of DNA in the cytoplasm. Persistently infected cells have not shown such synthesis, and ultraviolet-irradiated virus did not induce DNA synthesis. This new DNA presumably represents an intermediate in the virus replication cycle specified by the virion DNA polymerase(s). Failure to observe cytoplasmic DNA synthesis in persistently infected cells suggests, in keeping with the results of inhibitor experiments, that the new "viral" DNA becomes associated with cellular DNA in some form of stable interaction. PMID- 4331563 TI - Evidence for and localization of vegetative viral DNA replication by autoradiographic detection of RNA-DNA hybrids in sections of tumors induced by Shope papilloma virus. AB - The occurrence and localization of vegetative viral DNA replication was studied in sections of tumors induced by the rabbit Shope papilloma virus, in cottontail and domestic rabbit papillomas, in primary domestic rabbit carcinoma, and in transplantable VX2 carcinoma, by in situ hybridization of radioactive RNA complementary to viral DNA. Vegetative viral DNA replication and viral protein synthesis were compared by means of cytological hybridization and immunofluorescence techniques on adjacent frozen sections. Vegetative viral DNA replication is completely repressed in the proliferating cellular layers of these tumors, which suggests a provirus state of the viral genome, as in other cells transformed by oncogenic DNA viruses. Vegetative viral DNA replication is induced, after initiation of the keratinization, in cells of cottonail rabbit papillomas, where it is usually followed by viral protein synthesis; this illustrates the influence of the physiological state of the host cell on the control of viral functions. Vegetative viral DNA replication is deteced only in a few cells of domestic rabbit papillomas, at the end of the keratinization process; this observation provides indirect evidence that the DNA synthesis specifically induced in these tumors after the onset of keratinization reflects mostly the induction of cellular DNA synthesis. PMID- 4331564 TI - Stimulation of DNA-dependent RNA synthesis by a protein associated with ribosomes. AB - A protein factor partially purified from ribosomes of Escherichia coli RC(rel) cells starved for an amino acid markedly stimulates DNA-dependent RNA synthesis by core and whole RNA polymerase. This protein factor appears to differ from the sigma factor and the M factor. The properties of this new factor and its mechanism of action have been explored. PMID- 4331565 TI - The angiographic appearance of primary and secondary tumors of the liver. PMID- 4331566 TI - Hepatic angiography in the selection of patients with hepatomas for hepatic lobectomy. PMID- 4331567 TI - Infraorbital perineural invasion by tumor. PMID- 4331568 TI - Poland's syndrome. PMID- 4331569 TI - Premature closure of the frontosphenoidal suture in synostosis of the coronal suture. PMID- 4331570 TI - Radiation therapy in management of Wilms's tumor. PMID- 4331571 TI - Histidine biosynthesis and its regulation in higher plants. PMID- 4331572 TI - [Behavior of pancreatic islands of Langerhans in vitro., I. Preparation technic and critical evaluation of the method]. PMID- 4331573 TI - [Topohistochemistry of transmitter systems in the cortex and hippocampus of rabbits]. PMID- 4331574 TI - [Influencing of the impulse pattern of spontaneously acting neurons in the pontine reticular formation of the rat by noradrenaline, serotonin and acetylcholine]. PMID- 4331575 TI - [Comparative studies on the specificity of the histo-chemical demonstration of glucose-6-phosphatase]. PMID- 4331576 TI - Metabolic decomposition of chloramphenicol by Alcaligenes faecalis. PMID- 4331578 TI - Slow nerve conduction velocity in cretins. PMID- 4331579 TI - Thiosulfate-linked ATP-dependent NAD + reduction in Rhodopseudomonas palustris. PMID- 4331580 TI - Gradual enlargement of a retroauricular mass. PMID- 4331582 TI - Phosphodiesterase and ribonuclease activities of plasma membrane of rat liver and hepatoma. PMID- 4331581 TI - Properties of mesosomal membranes isolated from Micrococcus lysodeikticus and Bacillus megaterium. PMID- 4331583 TI - The bacterial oxidation of picolinamide. PMID- 4331585 TI - Recombination in vitro of proteins and lipids from mammalian erythrocyte membranes. PMID- 4331587 TI - Histone phosphokinase activity in nuclear and cytoplasmic cell fractions from normal and regenerating rat livers. AB - 1. Liver cell fractions were prepared by non-aqueous procedures and nuclei were also obtained in a hyperosmotic sucrose medium. Histone phosphokinase activity, assayed with histone F1 as substrate, was present in the soluble fraction of the cytoplasm and also bound on to the chromatin fraction of the nucleus. 2. The activity of the enzyme increased sixfold in nuclei from regenerating livers 22h after partial hepatectomy. 3. The enzyme bound in the nucleus was only marginally activated by 1mum-3':5'-cyclic AMP which stimulated the cytoplasmic soluble enzyme fourfold. 4. Nuclei prepared by the non-aqueous technique were also able to phosphorylate histones F2a and F3 and showed histone phosphatase activity with histone F1 phosphate as substrate. PMID- 4331588 TI - Tay-Sachs and other lipid storage diseases. PMID- 4331589 TI - Sperm velocity test in clinical practice. PMID- 4331586 TI - The distribution of some hydrolases in glomeruli and tubular fragments prepared from rat kidney by zonal centrifugation. AB - 1. A collagenase digest of rat kidney cortex was separated into four bands by zonal centrifugation. 2. Two of these bands were shown by light-microscopy to contain glomeruli and tubular fragments, which were free from each other and well separated from other renal material. 3. Protein, N-acetyl-beta-glucosaminidase, 5'-nucleotidase, l-leucine beta-naphthylamidase, leucine aminopeptidase, acid phosphatase and alkaline phosphatase were assayed across the gradient. 4. The greater proportion of these enzyme activities was recovered in the tubular fragments and acid phosphatase was the only enzyme detected in significant amounts in the glomeruli. 5. Tubular fragments and glomeruli were sedimented and multiple forms of beta-naphthylamidase, N-acetyl-beta-glucosaminidase, acid phosphatase and alkaline phosphatase were investigated by starch-gel electrophoresis. PMID- 4331590 TI - Humoral antibody response in female rats to antigens of male accessory sex glands. Effects of circulating antibodies on fertility. PMID- 4331592 TI - Effects of auto- and iso-immunization of bulls with semen and testis. PMID- 4331591 TI - Ovarian grafting in the rabbit with successful delivery of young. PMID- 4331593 TI - The time of onset of placental susceptibility in mice to heterologous anti-mouse placental serum. PMID- 4331594 TI - Male infertility following aortic surgery. PMID- 4331597 TI - Incorporation in vivo of intracisternally injected 33 P i into phospholipids of rat brain. PMID- 4331595 TI - Effects of vasopressin and prostaglandin E 1 on the adenyl cyclase-cyclic 3',5' adenosine monophosphate system of the renal medulla of the rat. AB - Vasopressin increased adenyl cyclase activity in homogenates of both inner and outer renal medulla of the rat. It also increased the concentration of cyclic 3',5'-adenosine monophosphate (AMP) in slices of both inner and outer medulla but not in renal cortex. In the inner medulla, a concentration of prostaglandin E(1) (PGE(1)), which was ineffective by itself significantly reduced the stimulation of adenyl cyclase activity and cyclic AMP concentration induced by vasopressin. These results are consistent with the hypothesis that PGE(1) can compete with vasopressin for adenyl cyclase-binding sites. However, the findings in the outer medulla suggest the situation is more complex. Although 10(-8) M PGE(1) had no effect by itself and inhibited the vasopressin-induced elevation of cyclic AMP, larger amounts of PGE(1) increased both adenyl cyclase activity and cyclic AMP levels. The maximum effect on the latter parameter was at least 6 times as great as that of maximum amounts of vasopressin. PMID- 4331596 TI - The effect of polystyrene beads on cyclic 3',5'-adenosine monophosphate concentration in leukocytes. AB - After incubation with polystyrene latex beads for 5 min. the cyclic 3',5' adenosine monophosphate (cyclic AMP) content of human peripheral blood leukocyte suspensions was increased severalfold. Preparations enriched in mononuclear cells and containing only 0-20% polymorphonuclear leukocytes (PMN) and no visible platelets exhibited a quantitatively similar response. Purified fractions of cells containing 85-90% PMN responded to polystyrene beads with a much smaller increase in cyclic AMP content. Phagocytosis of paraffin oil emulsion in the unfractionated mixed human leukocyte preparation was associated with little or no change in cyclic AMP levels. There was no change in cyclic AMP content of rabbit alveolar macrophages or guinea pig PMN during phagocytosis of polystyrene beads. All of these observations are consistent with the view that particle uptake per se does not increase cyclic AMP levels in phagocytic cells. It seems probable that the increase in cyclic AMP concentration that results when unfractionated human blood leukocytes are incubated with polystyrene beads occurs in cells other than PMN. PMID- 4331599 TI - Effect of tetanus toxin on the content of glycine, gamma-aminobutyric acid, glutamate, glutamine and aspartate in the rat spinal cord. PMID- 4331598 TI - Studies on the metabolic determinants of D-galactose-induced neurotoxicity in the chick. PMID- 4331600 TI - Effect of hypoxia on substrate levels in the brain of the adult mouse. PMID- 4331601 TI - Toxicity of Blastomyces dermatitidis. PMID- 4331602 TI - Tumour virology. Host ranges. PMID- 4331603 TI - Rifampicin and distamycin A as inhibitors of Rous sarcoma virus reverse transcriptase. PMID- 4331604 TI - Presynaptic inhibition in cuneate blocked by GABA antagonists. PMID- 4331605 TI - Association of viral reverse transcriptase with an enzyme degrading the RNA moiety of RNA-DNA hybrids. PMID- 4331606 TI - Vaccine-associated poliomyelitis in a child with thymic abnormality. PMID- 4331607 TI - Invasive amoebiasis: circulating antibody levels by latex agglutination test. PMID- 4331608 TI - [Ultrastructural localization of the activities of guanosine-5-triphosphatase, inosine-5-diphosphatase, glucose-6-phosphatase and acid phosphatase in lymphocytes transformed in vitro by phytohemagglutine]. PMID- 4331609 TI - [Luminescent method of diagnosing poultry diseases]. PMID- 4331610 TI - [Sleep and dreams from the point of view of pathophysiology]. PMID- 4331611 TI - [Late lesions following craniocerebral injuries]. PMID- 4331612 TI - Asymptomatic cytomegalovirus infection in children with leukemia. PMID- 4331613 TI - Approaches to antiviral chemotherapy. PMID- 4331614 TI - Diagnosis by endometrial jet washings. PMID- 4331616 TI - Electrolocation in fish. PMID- 4331615 TI - Identification of a pressor polypeptide in human amniotic fluid. PMID- 4331617 TI - [Fraser's syndrome. (Preliminary note)]. PMID- 4331618 TI - [A case of a cavum tumor revealed by orbital symptoms]. PMID- 4331619 TI - Purification on a structural glycoprotein from collagenase-digested experimental granuloma. PMID- 4331620 TI - A conformation change induced in the basic encephalitogen by lipids. PMID- 4331621 TI - [Isolation and properties of an anti A 1 phytohaemagglutin from Dolichos biflorus seeds]. PMID- 4331622 TI - Characterization of porcine malate dehydrogenase. I. An active center peptide. PMID- 4331623 TI - On the structure of renin substrate. PMID- 4331625 TI - [Photoinactivation of NAD-kinase from pigeon heart]. PMID- 4331624 TI - [Some characteristics of transcription processes in experimental hepatoma]. PMID- 4331626 TI - [DNA-independent and partially RNA-dependent RNA nucleotidyl-transferase activity in brain tissue of chick embryo]. PMID- 4331627 TI - [Serine transhydroxymethylase of cells and subcellular structures of liver and hepatoma]. PMID- 4331628 TI - [Therapeutic tips in dermatological practice]. PMID- 4331629 TI - The enzymatic hydrolysis of polyphosphates in tumor tissue. Its influence on the in vivo uptake. PMID- 4331630 TI - Intracellular distribution of lactate dehydrogenase isoenzymes in brain tumours. PMID- 4331631 TI - Enzyme determinations in three cases of trisomy 18 syndrome (Edwards' syndrome). PMID- 4331632 TI - [The regulation of cell function]. PMID- 4331633 TI - [Post-partum ACTH selective defficiency]. PMID- 4331634 TI - Aggregation of platelets of normal and Bordetella pertussis vaccinated mice by ATP, ADP, AND sodium fluoride. PMID- 4331635 TI - Structural analysis of nucleolar precursors of ribosomal ribonucleic acids. I. Isolation and characterization of the longest polypurine sequences of nucleolar 28 S ribonucleic acid and ribosomal 28 S ribonucleic acid of Novikoff hepatoma ascites cells. PMID- 4331636 TI - Cyclic nucleotide-dependent protein kinases. IX. Partial purification and some properties of guanosine 3',5'-monophosphate-dependent and adenosine 3',5' monophosphate-dependent protein kinases from various tissues and species of Arthropoda. PMID- 4331637 TI - Adenosine 3',5'-monophosphate-dependent protein kinase from bovine anterior pituitary gland. I. Properties. PMID- 4331638 TI - Adenosine 3',5'-monophosphate-dependent protein kinase from bovine anterior pituitary gland. II. Subcellular distribution. PMID- 4331639 TI - Antibody to genital herpes simplex virus: association with cervical atypia and carcinoma in situ. PMID- 4331640 TI - Tumor-induced skin heterogenization. I. Reciprocal relationship between tumors and skin grafts. PMID- 4331641 TI - Marek's disease herpesvirus in peripheral nerve lesions. PMID- 4331642 TI - Comparative urinary and gallbladder carcinogenicity of N-(4-(5-nitro-2-furyl)-2 thiazolyl)formamide and N-(4-(5-nitro-2-furyl)-2-thiazolyl)acetamide in the dog. PMID- 4331643 TI - Mouse mammary tumor virus infectivity as a function of age at inoculation, breeding, and total lapsed time. PMID- 4331644 TI - Tumors induced in the South American marmoset monkey by Rous sarcoma virus. PMID- 4331645 TI - Vinblastine sulfate: metaphase arrest, inhibition of RNA synthesis, and cytotoxicity in Novikoff rat hepatoma cells. PMID- 4331646 TI - Nucleoprotein complexes in simian virus 40-infected cells. AB - When African green monkey kidney cells (BSC-1) were infected with simian virus 40 (SV40) and extracted with 0.25% Triton X-100 after exposure to (3)H-thymidine, the (3)H-SV40 deoxyribonucleic acid (DNA) was present in a form which had a sedimentation coefficient in sucrose gradients of 44S. The change from the sedimentation coefficient of purified SV40 DNA (21S) was shown to result from the association of the SV40 DNA in the Triton extracts with protein by means of sensitivity to Pronase digestion and labeling with (14)C-amino acids. Short-term labeling experiments with (3)H-thymidine demonstrated that SV40 DNA molecules in the course of replication (25S) were also present as nucleoprotein complexes in Triton-extracted material. Labeled DNA extracted with Triton in the form of nucleoprotein complexes was obtained in amounts which were quantitatively equivalent to the amounts extracted with deoxycholate in parallel experiments. This indicated that the newly synthesized pools of SV40 DNA may not occur as free DNA in the infected cell. PMID- 4331647 TI - Homologous interference by incomplete Sendai virus particles: changes in virus specific ribonucleic acid synthesis. AB - Incomplete Sendai virus particles (I particles) interfered with the replication of several strains of infectious Sendai virions (standard virus) but not with the replication of Newcastle disease virus, mumps virus, or Sindbis virus. I particles did not induce interferon, and ultraviolet irradiation of I particles abolished their ability to interfere. Protein synthesis was not necessary to establish interference. The degree of interference depended on the interval between exposure of cells to the I particles and challenge by standard virus, and this was reflected in the degree of inhibition of virus-specific ribonucleic acid (RNA) synthesis in infected cells. The most dramatic change was decreased accumulation of 50S virus-specific RNA in infected cells. RNA species sedimenting slower than 50S were not as markedly reduced in total amount, but hybridization experiments showed that a substantial portion of these slowly sedimenting RNA species were plus strands, presumably representing replicas of the RNA species in I particles. When I particles in insufficient numbers to interfere were added to cells as late as 8 hr after standard virus, there were no obvious changes in virus-specific RNA species in the cells; however, significant amounts of 19 and 25S RNA species, representing progeny of the I particles, appeared in the culture medium. It was concluded that interference was an intracellular event affecting an early step in virus replication. Competition by I particles for cell sites or substrates needed by standard virus seemed a less likely mechanism of interference than competition for enzymes specified by standard virus. PMID- 4331648 TI - Effect of pactamycin on synthesis of poliovirus proteins: a method for genetic mapping. AB - We have studied the effect of the drug pactamycin on protein synthesis in poliovirus-infected HeLa cells. At a concentration which primarily inhibits initiation of protein synthesis, the spectrum of poliovirus proteins synthesized is markedly changed. The amount of NCVP 1, the capsid precursor, is greatly reduced relative to NCVP 2 and the amount of NCVP X is slightly reduced. Since it is believed that there is only one major site for the initiation of protein synthesis on the poliovirus genome, we interpret this differential effect on the poliovirus proteins to be an indication of their relative distance from the initiation site. On this basis, we propose a gene order for the poliovirus genome (5' --> 3') of NCVP 1, NCVP X, NCVP 2. PMID- 4331649 TI - Enzymes and nucleotides in virions of Rous sarcoma virus. AB - In addition to the previously described deoxyribonucleic acid (DNA) polymerase, DNA ligase, DNA exonuclease, and DNA endonuclease activities, purified virions of Schmidt-Ruppin strain of Rous sarcoma virus (SRV) have nucleotides and nucleotide kinase, phosphatase, hexokinase, and lactate dehydrogenase activities. The SRV virions have no glucose-6-phosphate dehydrogenase activity. All enzyme activities, but glucose-6-phosphate dehydrogenase and adenosine triphosphatase, were increased by disruption of the virions. The DNA polymerase, DNA ligase, and hexokinase activities had a higher specific activity in purified virion cores. It is suggested that during assembly virions of SRV may pick up cytoplasmic components which bind to virion proteins. The role of these components in viral replication is not known at present. PMID- 4331650 TI - Spontaneous virus production by clonal lines of siminan virus 40-transformed cells and effects of superinfection by deoxyribonucleic acid from mutant simian virus 40 strains. AB - Small amounts of infectious simian virus 40 (SV40) were recovered from parental cultures of SV40-transformed human embryonic lung (WI38 Va13A) cells, from 12 primary clones, from 17 secondary clones, and from 18 tertiary clones. The cloning experiments demonstrated that the capacity for spontaneous virus production is a hereditary property of WI38 Va13A cells. Infectious virus was not recovered from every clone at every passage. Repeated trials at different passage levels were necessary to detect virus production. Approximately one in 10(5) to 10(6) of the cells of the clonal lines initiated plaque formation when plated on the CV-1 line of African green monkey kidney cells. No increase in infectious center formation was observed after the clonal lines were treated with bromodeoxyuridine, iododeoxyuridine, or mitomycin C or after heterokaryon formation of treated cells with CV-1 cells. The clonal lines of WI38 Va13A cells were susceptible to superinfection by SV40 deoxyribonucleic acid (DNA). To determine whether only those cells which spontaneously produced virus supported the replication of superinfecting SV40 DNA, cultures were infected with DNA from a plaque morphology mutant and a temperature-sensitive mutant of SV40. After infection by SV40 DNA, approximately 100 to 4,400 times more transformed cells formed infectious centers than were spontaneously producing virus. To determine whether the resident SV40 genome or the superinfecting SV40 genome was replicating, infectious centers produced by SV40 DNA-infected WI38 Va13A cells on CV-1 monolayers were picked and the progeny virus was analyzed. Only the superinfecting SV40 was recovered from the infectious centers, indicating that in the majority of superinfected cells the resident SV40 was not induced to replicate. PMID- 4331651 TI - Structure of replicating simian virus 40 deoxyribonucleic acid molecules. AB - Properties of replicating simian virus 40 (SV40) deoxyribonucleic acid (DNA) have been examined by sedimentation analysis and by direct observation during a lytic cycle of infection of African green monkey kidney cells. Two types of replicating DNA molecules were observed in the electron microscope. One was an open structure containing two branch points, three branches, and no free ends whose length measurements were consistent with those expected for replicating SV40 DNA molecules. A second species had the same features as the open structure, but in addition it contained a superhelix in the unreplicated portion of the molecule. Eighty to ninety per cent of the replicative intermediates (RI) were in this latter configuration, and length measurements of these molecules also were consistent with replicating SV40 DNA. Replicating DNA molecules with this configuration have not been described previously. RI, when examined in ethidium bromide-cesium chloride (EB-CsCl) isopycnic gradients, banded in a heterogeneous manner. A fraction of the RI banded at the same density as circular SV40 DNA containing one or more single-strand nicks (component II). The remaining radioactive RI banded at densities higher than that of component II, and material was present at all densities between that of supercoiled double-stranded DNA (component I) and component II. When RI that banded at different densities in EB CsCl were examined in alkaline gradients, cosedimentation of parental DNA and newly replicated DNA did not occur. All newly replicated DNA sedimented more slowly than did intact single-stranded SV40 DNA, a finding that is inconsistent with the rolling circle model of DNA replication. An inverse correlation exists between the extent of replication of the SV40 DNA and the banding density in EB CsCl. Under alkaline conditions, the parental DNA strands that were contained in the RI sedimented as covalently closed structures. The sedimentation rates in alkali of the covalently closed parental DNA decreased as replication progressed. Based on these observations, some possible models for replication of SV40 DNA are proposed. PMID- 4331652 TI - Synthesis of capsid and noncapsid viral proteins in response to encephalomyocarditis virus ribonucleic acid in animal cell-free systems. AB - The polypeptide products formed in two cell-free protein-synthetic systems programmed with encephalomyocarditis (EMC) virus ribonucleic acid (RNA) have been compared with the virus-specific proteins found in EMC-infected cells and with the capsid proteins of the purified virion. Tryptic peptides of (35)S methioninelabeled proteins from these three sources were compared by co chromatography and electrophoresis and by isoelectric focussing. Fifty-two methionine-containing peptides were resolved in digests of material from infected cells, of which about one-third were also clearly present in digests of the virion capsid proteins. The product formed in response to EMC RNA in cell-free systems from Krebs mouse ascites tumor cells yielded 26 to 29 such peptides. Most of these peptides were shown to behave identically with virus-specific peptides from infected cells, whereas just under half of them appeared to be identical with peptides from the virion capsid proteins. The product formed in response to EMC RNA in the L-cell cell-free system was similar, whereas six additional EMC specific peptides were detected in mixed Krebs L-cell systems. The results indicate that the EMC RNA genome is partially translated in the mouse cell-free systems used to yield products containing both virion capsid and virus-specific noncapsid polypeptides. PMID- 4331653 TI - Relationship between the ribonucleic acid synthesizing capacity of ultraviolet irradiated Newcastle disease virus and its ability to induce interferon. AB - Ultraviolet (UV)-irradiated Newcastle disease virus which has lost its infectivity but has the capacity to induce interferon also has the capacity to induce ribonucleic acid (RNA) synthesis both in vitro and early in infection in vivo. With large doses of UV irradiation, RNA-synthesizing capacity and interferon-inducing capacity are lost in parallel. Limited amounts of base-paired RNA associated with a transcriptive intermediate are involved in this RNA synthesis. These findings suggest the possibility that the single-stranded RNA of the UV-irradiated virus induces interferon by serving as a template for the synthesis of base-paired RNA. UV irradiation of the virus breaks down viral RNA but at a rate which is too slow to be a major cause of the loss of RNA synthesizing capacity. Evidence is presented which suggests that less of the template RNA of the UV-irradiated virus is copied and that the product which is synthesized is smaller than that synthesized by nonirradiated virus. PMID- 4331654 TI - Specific alterations of coxsackievirus B3 eluted from HeLa cells. AB - After the attachment of radioactive coxsackievirus B3 to HeLa cells at 0 C and subsequent incubation at 37 C, 50 to 80% of attached virus radioactivity was eluted from the cells within 1 hr. Eluted virus had a buoyant density of 1.21 in a potassium tartrate gradient, sedimented more slowly than native virus in sucrose gradients, was resistant to ribonuclease, was unstable in CsCl centrifugation, and did not reattach to uninfected cells. Electrophoretic studies of sodium dodecyl sulfate-disrupted B3 virus in sodium dodecyl sulfate polyacrylamide gels revealed four radioactive virus polypeptides (VP 1 to 4), of which the three largest migrated slightly faster than their poliovirus T1 counterparts. In contrast, electrophoretic analysis of eluted virus, after banding in a tartrate gradient or pelleting by centrifugation, showed the absence of the fastest migrating polypeptide, VP 4. VP 4 was recovered in the supernatant fluid when the eluted virions were removed by high-speed centrifugation. The results indicate that VP 4 is located at the surface of the native virion, and its dissociation from the capsid may represent the first specific alteration of the virion after virus-receptor interaction at the cell surface. PMID- 4331655 TI - Temperature-sensitive mutants of simian virus 40: infection of permissive cells. AB - Ten temperature-sensitive mutants of simian virus 40 have been isolated and characterized in permissive cells. The mutants could be divided into three functional groups and two complementation groups. Seven mutants produced T antigen, infectious viral deoxyribonucleic acid (DNA), and structural viral antigen but predominantly the empty shell type of viral particles. Two mutants produced T antigen and infectious viral DNA, but, although viral structural protein(s) could be detected immunologically, no V antigen or viral particles were found. These two functional groups of mutants did not complement each other. A single mutant was defective in the synthesis of viral DNA, viral structural antigens, and viral particles. T antigen could be detected in infected cells by fluorescent antibody but was reduced by complement fixation assay. This mutant stimulated cell DNA synthesis at the restrictive temperature and complemented the other two functional groups of mutants. PMID- 4331656 TI - Antigenic specificity of poliovirus-related particles. AB - Poliovirus-specific structures with sedimentation constants of 5, 14, 73, and 150S produced in infected HeLa cells possess different antigenic specificities. PMID- 4331657 TI - Herpes vimplex virus: genome size and redundancy studied by renaturation kinetics. AB - Herpes simplex virus subtype 1 deoxyribonucleic acid (DNA) was sheared in a French press to uniform fragments, denatured by heating, then allowed to reassociate. The renaturation reaction followed second-order kinetics with a single rate constant indicating that at least 95% of the genome was unique and that repetitive sequences, if present, were not detectable by this technique. The kinetic complexity of the herpes simplex genome was determined by DNA renaturation kinetics to be (95 +/- 1) x 10(6) daltons. Since this value is in excellent agreement with the molecular weight of viral DNA [(99 +/- 5) x 10(6) daltons] obtained from velocity sedimentation studies, it is concluded that virions contain only one species of double-stranded DNA molecules 95 x 10(6) to 99 x 10(6) daltons in molecular weight. PMID- 4331658 TI - Repair replication of HeLa cell deoxyribonucleic acid in cells infected with Newcastle disease virus or mengovirus or treated with puromycin. AB - We examined repair replication of HeLa cell deoxyribonucleic acid (DNA) in cells infected with mengovirus or Newcastle disease virus or treated with puromycin. Cellular DNA was damaged by ultraviolet light and then pulse-labeled with (3)H thymidine. Autoradiographic analysis of non-S-phase DNA synthesis (repair replication) showed that there was no inhibition of this process at a time when overall cellular DNA synthesis was severely inhibited by either virus infection or puromycin treatment. PMID- 4331659 TI - X-ray-enhanced reactivation of ultraviolet-irradiated human virus. AB - When CV-1 mammalian cells were X-irradiated before infection with ultraviolet (UV)-irradiated herpes simplex virus, an increase in survival of this virus was observed. X-ray reactivation is proposed as the name of this phenomenon by analogy with UV reactivation. The amount of survival enhancement was about the same as that found for UV reactivation in the same virus-host system. The enhancement reached a plateau at approximately 1000 rads and appeared to be radiation-insensitive at high doses. PMID- 4331660 TI - Cytoplasmic crystals in human hepatocytes. PMID- 4331662 TI - The renin-angiotensin system in acute renal failure in the rat. PMID- 4331661 TI - A study of Ca 2+ metabolism in kidney mitochondria during acute uranium intoxication. PMID- 4331663 TI - Cellular degeneration in developing central nervous system of rats produced by hypocholesteremic drug AY9944. PMID- 4331664 TI - Further studies on an esterase inhibitor in human leukocyte cytosol. PMID- 4331665 TI - Studies on multiple renal lesions in Heymann nephritis. PMID- 4331666 TI - Foam cells of rabbit atheromatous lesion. Identification and cholesterol uptake in isolated cells. PMID- 4331668 TI - Comparative electron microscope studies on the epidermis of the blood living juvenile and gill living adult stages of Amphibdella flavolineata (Monogenea) from the electric ray Torpedo nobiliana. PMID- 4331667 TI - Reverse transcriptase, the DNA polymerase of oncogenic RNA viruses. PMID- 4331669 TI - Gland cells and secretions in the miracidium of Fasciola hepatica. PMID- 4331670 TI - [Organization of the multienzyme complexes]. PMID- 4331672 TI - Sizing up the small child. PMID- 4331671 TI - [Pectate lyase]. PMID- 4331673 TI - [Reproduction of DNA viruses]. PMID- 4331674 TI - The incidence of Australia antigen-antibody in acute and chronic liver disease. PMID- 4331675 TI - Antibodies to cytomegalovirus and other members of the herpes group in women and children in Singapore. PMID- 4331676 TI - A longitudinal study of steroid excretion patterns in children during adolescent growth. PMID- 4331677 TI - [Acute aphthous and herpetic stomatitis in children]. PMID- 4331678 TI - [Therapeutic uses of phosphorus. Review of literature]. PMID- 4331679 TI - [Differentiation of murine leukemia viruses from elementary bodies of mycoplasma by electron microscopy]. PMID- 4331680 TI - Autoradiographic study of biosynthesis of DNA, RNA and protein in cell cultures infected with herpes simplex virus. PMID- 4331681 TI - [Reaction of complement-fixing antigens of Sendai virus to various agents]. PMID- 4331682 TI - [Dynamics of RNA and protein content in primate reticular cell cultures in controls and in poliovirus infection (cytophotometric studies)]. PMID- 4331684 TI - [Cultivation of some respiratory viruses in organ cultures of human embryo]. PMID- 4331683 TI - [Characteristics of multiplication of 5 serotypes of rhinoviruses and their antigenic relations]. PMID- 4331685 TI - [Long-term observation on the level of antibodies to adenoviruses in children in a children's home]. PMID- 4331686 TI - [Intranuclear precursors of Sendai virus ribonucleoproteins]. PMID- 4331687 TI - [Preparation of specific immune serum to Sendai virus ribonucleoprotein]. PMID- 4331688 TI - [Possible relation between the level of poliovirus multiplication and conformation of cation-carrying ATPase of host cells]. PMID- 4331689 TI - [Study of some stages of poliomyelitis virus morphogenesis]. PMID- 4331690 TI - [Current views on the therapy of hepatic coma]. PMID- 4331692 TI - [Serologic diagnosis of influenza and infection in East Thuringia during 1962 1967--analysis and conclusions]. PMID- 4331691 TI - [The epidermolysis syndrome (Lyell) from the viewpoint of internal medicine]. PMID- 4331693 TI - [Carbon tetrachloride in its effects on peripheral nerves (experimental study on rabbits)]. PMID- 4331694 TI - Determination of acetylcholine and choline by an enzymatic assay. PMID- 4331695 TI - Effect of histamine and its derivatives on lipolysis in isolated rat fat cells. PMID- 4331696 TI - Effects of muscarinic ganglionic stimulation and blockade upon ganglion responses to DMPP and nicotine. PMID- 4331697 TI - Low-resistance junctions between cells in embryos and tissue culture. PMID- 4331698 TI - Levels of control: a useful frame of perception. PMID- 4331699 TI - [Statistical evaluation of neuronal discharge]. PMID- 4331700 TI - [Functional morphology of the endostyle and thyroid gland of the brook lamprey (Lampeta planeri Bloch). II. Studies of the thyroid gland]. PMID- 4331701 TI - An ultrastructural study of the islet cell tumor of the golden hamster. PMID- 4331702 TI - Adrenal cells in tissue culture. 8. Dissociation of the steroidogenic and glycolytic effects of cyclic nucleotides and adrenocorticotropin. PMID- 4331703 TI - Input and output signals in a model neural system: the regulation of melatonin production in the pineal gland. PMID- 4331704 TI - Thin-layer chromatographic separation of equine estrogens on silica gel H-silver nitrate plates. PMID- 4331705 TI - Cystosarcoma phyllodes: a review of the literature. PMID- 4331706 TI - [Studies of leukocyte metabolism. V. NAD and ATP in isolated leukocytes and erythrocytes in human leukemias under the effect of cytostatic compounds C73, busulfan and cyclophosphamide]. PMID- 4331707 TI - [Electron microscopic identification of enzymes in the suspensions of cellular components]. PMID- 4331709 TI - [Carcinogenesis and virus; EB virus and human cancer]. PMID- 4331708 TI - Effects of cyclic-3',5'-adenosine monophosphate and of cibutyrl-3',5'-adenosine monophosphate on the fatty acid synthesizing system of rat brown adipose tissue. PMID- 4331710 TI - [Vertigo in neuropathies]. PMID- 4331711 TI - Clinical aspects of uraemic polyneuropathy. PMID- 4331712 TI - Electron microscope study of the blood stages of Plasmodium tropiduri, a lizard malaria parasite. PMID- 4331713 TI - [Therapy of gout attacks with synthetic delayed-action ACTH]. PMID- 4331714 TI - Polyoma "tumor antigen": an activator of chromosome replication? AB - We have studied the temporal relationship between the appearance of polyoma specific "tumor antigen" and polyoma-induced activation of the cellular DNA synthesizing apparatus in "contact-inhibited" mouse-kidney tissue-culture cells. The experimental results are compatible with the hypothesis that virus-induced replication of the mouse cell chromosomes, which accompanies the actual production of progeny virus, is triggered by the tumor antigen. On the basis of the experimental evidence at present available we propose a tentative scheme of the lytic cycle of polyoma virus, that is of the events which lead to and accompany the production of polyoma progeny virus. PMID- 4331715 TI - DNA synthesis by RNA-containing tumor viruses. AB - Murine leukemia (Rauscher and Moloney strains) and sarcoma (Kirsten strain) virions, as well as the mammary tumor virus of mice, contain an RNA-dependent DNA polymerase. Optimal incorporation of deoxyribonucleoside triphosphates occurs at a critical detergent (Triton X-100) concentration (0.010-0.014%). At higher than optimal detergent concentrations the virion is seen to be disrupted and enzyme activity is lost. The virion, enzymatic activity, and newly synthesized DNA all cosediment in a sucrose gradient. Thus far the enzymatic activity has been found only in RNA viruses that have oncogenic properties. PMID- 4331717 TI - Coboglobins: oxygen-carrying cobalt-reconstituted hemoglobin and myoglobin. AB - In this work we show that it is possible to prepare and study a cobalt substituted hemoglobin-a coboglobin (Cb).-and that this reconstituted metalloprotein exhibits reversible oxygen binding. The effect of the protein environment on Co(II)-protoporphyrin IX is directly observed by esr measurements on deoxy- and oxy-Cb and by oxygen uptake measurements, all of which may be compared with similar measurements on the free metalloporphyrin. Reversing our point of view, we compare oxygen binding to Cb with that of hemoglobin, and thus investigate the relationship of the metal atom and metaloxygen binding to such characteristics of the nature proteins as cooperative oxygen uptake. PMID- 4331716 TI - Effect of loss of thymidine kinase activity on the tumorigenicity of clones of SV40-transformed hamster cells. AB - Cells deficient in the enzyme thymidine kinase were derived from transplantable SV40-transformed hamster cells. The resultant cell lines were less transplantable when inoculated into hamsters. Tumors which did arise from such cells had prolonged latent periods and were found to contain a mixture of enzyme-containing and enzyme-deficient cells. Revertant cell lines obtained either spontaneously or after mutagenesis in vitro contained intermediate levels of thymidine kinase activity and displayed an oncogenic potential which was intermediate between the wild type and enzyme-deficient cells. It is postulated that salvage pathway enzymes may play a rate-limiting role in tumorigenesis. PMID- 4331718 TI - Cyclic adenosine 3':5'-monophosphate-stimulated phosphorylation of isolated neurotubule subunits. AB - The possible relationship between cyclic adenosine 3':5'-monophosphate (cAMP) and neurotubules in synaptic transmission has been explored. The neurotubular subunit protein from bovine cerebral cortex has been prepared. The addition of cAMP to this preparation in the presence of ATP stimulates the phosphorylation of serine residue(s) in the principal component of the preparation. The neurotubule subunit thus serves as a substrate for an intrinsic, cyclic nucleotide-dependent protein kinase closely associated with the neurotubule subunit. The significance of this finding is discussed in terms of a general model for cellular secretion involving microtubules, cyclic AMP, protein kinase, and calcium ion. PMID- 4331719 TI - Increase in preexisting cellular antigen-combining groups at different times after infection with different viruses. AB - During the course of experiments designed to determine whether infection of normal cells with certain strains of Herpesvirus hominis (HSV) gives rise to a specific neoantigen, presumably characteristic for human malignant cells ("HeLa G"), it was found that the seeming appearance of such a new antigen actually represents only an increase in concentration of previously existing normal antigen groups. The complement fixation tests for this antigen were carried out with antibody prepared by McKenna against a fraction, purified with the fluorocarbon genetron, from HeLa cells. This antibody reacted with extracts of tissue culture cells derived from various human malignant tumors and from the spontaneously transformed WISH cell line, originally derived from normal human amnion, but not with cells derived from early-passage cultures of normal human kidney, or from primary cultures of young rabbit kidney or new-born guinea pig kidney. Infection of rabbit and guinea pig kidney tissue culture cells with HSV strains derived from brain or lip lesions at a high input multiplicity of virus failed to yield the "G" antigen. Infection of human kidney tissue culture cells with the same HSV strains yielded two units of the "G" antigen at 6 hr and 32 units at 24 hr. The conclusion that this was, nevertheless, not a new antigen, but only an increase in amount of preexisting antigen, was based on the demonstration that absorption of the anti-"HeLa G" globulin with uninfected human kidney tissue culture cells completely removed the antibody for the "G" antigen formed during the course of infection with HSV and also that present in uninfected WISH and HEp2 cells. Infection by the same HSV strains of the human WISH cells which have a small amount of preexisting "G" antigen resulted in an increase which was maximal at 24 hr. Infection of WISH cells with vaccinia virus resulted in a rapid increase of "G" antigen, which was demonstrable at 10 min but not at 3, 6, and 24 hr. Absorption of the anti-"HeLa G" globulin with uninfected WISH cells removed the antibody for the G antigen present in the WISH cells before infection as well as after infection with the herpes and vaccinia viruses, and also the antigen present in human tissue culture cells of malignant origin. PMID- 4331720 TI - Enzymatic block in the synthesis of gangliosides in DNA virus-transformed tumorigenic mouse cell lines. AB - The ganglioside pattern of both SV40- and polyoma virus-transformed mouse cell lines differs from that of the parent cell lines or of cell lines that have transformed spontaneously in tissue culture. This is manifested by a dramatic decrease of gangliosides with an oligosaccharide chain larger than sialyllactose. Present investigations indicate that this change probably cannot be attributed to excessive catabolism of gangliosides, but is caused by impaired synthesis of tri- and tetrahexosyl gangliosides in the virus-transformed cell lines. We present evidence for the block of a required step for the biosynthesis of these ganglioside homologs. The block involves the enzyme catalyzing the transfer of N acetylgalactosamine from uridine diphosphate N-acetylgalactosamine to hematosides (N-glycolylneuraminyl or N-acetylneuraminylgalactosylglucosyl ceramide). This well-defined enzymatic change opens the way for studies of the biochemical mechanism of the alteration of cell membranes which occurs after transformation by the tumorigenic DNA viruses polyoma and SV40. PMID- 4331722 TI - Isolation of a second avian leukosis group-specific antigen (gs-b) from avian myeloblastosis virus. AB - Gs-b, a second group-specific antigenic protein of the avian leukosis group, has been isolated from Tween 80-ether treated avian myeloblastosis virus by Sephadex and carboxymethylcellulose chromatography, and compared by immunological and chemical means with the antigen (gs-a) described previously. PMID- 4331721 TI - Correlation of adrenocorticotropic activity of ACTH analogs with degree of binding to an adrenal cortical particulate preparation. AB - This study deals with the interaction of polypeptide hormones with their receptors. Specifically it involves the binding of synthetic ACTH analogs and fragments to a particulate fraction from beef adrenal cortical tissue. This fraction was found to bind synthetic [(14)C-Phe] [Gln(5)]beta-corticotropin(1-20) amide but failed to bind significant amounts of [(14)C-Phe] [Gln(5)]beta corticotropin(1-10). The former peptide exhibits a high degree in vivo adrenocorticotropic activity in the rat; the latter is inactive. [(14)C-Phe] [Gln(5)]beta-corticotropin(1-20) amide exhibited little affinity for similarly prepared particulates from beef kidney, liver, or adrenal medulla. Using a series of synthetic homogeneous nonradioactive analogs or fragments of beta corticotropin(1-20) amide to displace [(14)C-Phe] [Gln(5)]beta-corticotropin(1 20) amide from the particulate fraction a significant correlation between binding and in vivo adrenocorticotropic activity was established. Major "active" and "binding" sites were shown to reside in different sections of the ACTH molecule. Charged groups play a major role in the attachment of ACTH to the particulate fraction and the sequence Lys-Lys-Arg-Arg proved to be particularly significant. The high degree of binding specificity for ACTH peptides which is exhibited by the particulate suggests that it contains ACTH receptor(s). Moreover, the striking similarity between observations with the S-peptide-S-protein model system and the system described would seem to indicate that the ACTH receptor is a protein. PMID- 4331723 TI - Evidence for a DNA replicative genome for RNA-containing tumor viruses. AB - The requirement for DNA synthesis in the reproduction of RNA tumor viruses was examined using 5-bromodeoxyuridine (BrdU). Addition of BrdU for the first 12 hr after exposure of cells to Rous sarcoma virus resulted in a large decrease in infectious progeny. However, incorporation of [(3)H]uridine into the viral RNA of virions was unaffected. Also, the numbers of virions visualized by electron microscopy were similar in BrdU-treated and untreated samples. Viral group specific antigen was synthesized after BrdU treatment, and BrdU had little effect on transformation of cells by Rous sarcoma virus. The results support the hypothesis that the replicative genome of RNA-containing tumor viruses contains DNA. PMID- 4331724 TI - Elevated concentration of adenosine 3':5'-cyclic monophosphate in intestinal mucosa after treatment with cholera toxin. AB - A heat-labile factor in cell-free filtrate of a Vibrio cholerae culture induces a marked rise in the wet-weight concentration of adenosine 3':5'-cyclic monophosphate (cyclic AMP) in the intestinal mucosa of the dog. The increase becomes appreciable 1-1.5 hr after intraluminal administration of the filtrate, about the same time as the onset of intestinal secretion in response to a heat labile enterotoxin in the filtrate. These results are consistent with the hypothesis that cyclic AMP may be an intermediary in the intestinal secretory response to cholera toxin. PMID- 4331725 TI - A possible role of phospholipid in nerve excitation. AB - A possible role of phospholipid in regulating the ionic permeability of excitable membranes is proposed. It is assumed that each excitable transport channel in the nerve fiber is lined with two chains of phospholipid dipoles in either parallel or antiparallel directions; a molecular mechanism of nerve excitation is developed that is qualitatively consistent with most of the relevant observations reported in the literature. PMID- 4331726 TI - Electroencephalographic and behavioral effects of harmaline in intact cats and in cats with chronic mesencephalic transection. PMID- 4331727 TI - Cell transformation induced by Rous sarcoma virus: analysis of density dependence. PMID- 4331729 TI - The kinetics of rescue of the murine sarcoma virus genome from a nonproducer line of transformed mouse cells. PMID- 4331728 TI - The lipid class composition of Semliki forest virus and plasma membranes of the host cells. PMID- 4331730 TI - Proteins associated with the poliovirus RNA replication complex. PMID- 4331731 TI - Genetic expression in bacteriophage lambda. IV. Effects of P2 prophage on lambda inhibition of host synthesis and lambda gene expression. PMID- 4331732 TI - The effects of reciprocal changes in temperature on the transformed state of cells infected with a rous sarcoma virus mutant. PMID- 4331733 TI - Murine sarcoma and leukemia viruses: genetic differences determined by RNA-DNA hybridization. PMID- 4331734 TI - Host cell protein synthesis after infection with bluetongue virus and reovirus. PMID- 4331735 TI - [Expedient therapy of chronic pyelonephritis]. PMID- 4331736 TI - [Effect of electric double stimulation and cardio-active drugs on the hypodynamic heart in the dog]. PMID- 4331737 TI - [Study of the thrombocytic adhesion index in multiple sclerosis]. PMID- 4331738 TI - Development of antibodies during long-term therapy with corticotrophin in rheumatoid arthritis. I. Porcine ACTH. PMID- 4331739 TI - Development of antibodies during long-term therapy with corticotrophin in rheumatoid arthritis. II. Zinc tetracosactrin (Depot Synacthen). PMID- 4331741 TI - Incorporation of 3 H-uridine into RNA of toad bladder epithelial cells. Method of determination. PMID- 4331740 TI - Control of heme biosynthesis. Effect of nicotinamide adenine dinucleotide on the induction of -aminolevulinate synthetase. PMID- 4331742 TI - Preparation of a NAD(H)-polymer matrix showing coenzyme function of the bound pyridine nucleotide. PMID- 4331743 TI - Herpesvirus ubique. PMID- 4331744 TI - Characterization of various types of rat cutaneous anaphylaxis from their drug susceptibilities. PMID- 4331745 TI - [Nucleosidtriphosphatase-positive dendritic cells in the oesophageal epithelium of the guinea-pig]. PMID- 4331747 TI - Intranuclear inclusions in neurones and glia: a study in the ageing mouse. PMID- 4331746 TI - A histochemical study of cellular reactions in rat retina transiently damaged by visible light. PMID- 4331748 TI - Studies related to penicillins. V. The conversion of 6 -phthalimidopenicillanic acid into cepham derivatives. PMID- 4331749 TI - Genetic variability of skeletal maturity in human twins. PMID- 4331750 TI - Congenital hand deformities. PMID- 4331751 TI - The treatment of malignant tumors in childhood. PMID- 4331752 TI - [Endocrinologically active pancreatic neoplasms]. PMID- 4331753 TI - [Intravenous hepatosplenography. Possibilities of performance and preliminary results in some animal species]. PMID- 4331755 TI - Effect of metyrapone, prednisolone and insulin treatment on the domestic pigeon's hypothalamus. PMID- 4331756 TI - Breakdown of adenosine triphosphate by muscle preparations in the presence of perchloric acid. PMID- 4331754 TI - [Pathogenesis of essential hypertension with special reference to therapy]. PMID- 4331757 TI - Direct spectrophotometric determination of inorganic sulfide in biological materials and in other complex mixtures. PMID- 4331758 TI - Determination of small amounts of pregnenolone. PMID- 4331759 TI - Synthesis of (26,27- 3 H)-25-hydroxycholecalciferol. PMID- 4331761 TI - A new simple method for separation of adenosine 3',5'-cyclic monophosphate from other nucleotides and its use in the assay of adenyl cyclase. PMID- 4331760 TI - Spectrophotometric determination of nucleic acids and nucleoproteins at the far UV region. PMID- 4331762 TI - Detection of endo-acting carbohydrases, particularly in the presence of exoenzymes acting on the smae substrate. PMID- 4331763 TI - Gas and thin-layer chromatographic methods for analysis of the mycotoxins altenuene, alternariol, and alternariol monomethyl ether. PMID- 4331764 TI - 3',5'-cyclic adenosine monophosphate phosphodiesterase assay using high speed liquid chromatography. PMID- 4331765 TI - [Syndrome of Guyon's tunnel]. PMID- 4331766 TI - Improvements in the growth of BHK-21 cells in submerged culture. AB - A medium is described which will support the submerged culture of BHK-21 cells to 6.5 x 10(6) to 7 x 10(6) cells/ml in volumes up to 30 liters. Shaken-flask cultures were used to determine nutrient deficiencies in depleted medium. The final medium became limited by glutamine at 6.5 x 10(6) to 7 x 10(6) cells/ml, but increasing the glutamine concentration failed to improve cell yields. The value of the polyol Pluronic F68 as a protective substance is illustrated. PMID- 4331767 TI - Electrophoretic analysis of ribosomal and viral ribonucleic acids with a simple technique for slicing low-concentration polyacrylamide gels. AB - The electrophoretic mobilities of ribosomal ribonucleic acids (RNA) from cultured mammalian (HeLa, Vero, MDBK), avian (chick embryo), and bacterial (Escherichia coli) cells, and RNA species extracted from selected viruses (Sindbis, polio, tobacco mosaic, Sendai) were compared, employing a simple, inexpensive technique for slicing low-concentration polyacrylamide gels. The procedure provides for rapid fractionation of gels used for characterization of RNA, incorporating extrusion and serial sectioning of frozen gels. Among 28S ribosomal RNA species, Vero and MDBK were indistinguishable, whereas HeLA RNA had a slightly lower mobility (higher apparent molecular weight) and chick RNA had a higher mobility (lower apparent molecular weight). The 18S ribosomal RNA species of the three mammalian sources were indistinguishable, but chick 18S RNA had a slightly lower apparent molecular weight. The inverse relation between mobility and log molecular weight among the ribosomal and viral RNA species, though not highly precise, demonstrates the applicability of the technique to the study of molecular weights of viral RNA species. PMID- 4331768 TI - Enumeration and identification of Bacillus cereus in foods. I. 24-hour presumptive test medium. AB - An egg yolk-polymyxin medium (KG) for rapid enumeration of Bacillus cereus is described. The test is presumptive in that differentiation of B. cereus (and closely related organisms) from other species is based on the formation of turbidity in the agar surrounding the colonies of the cereus group organisms. The medium is formulated to encourage sporulation and release of free spores for serological confirmatory tests within the 24-hr incubation period. The production of turbidity in egg yolk and free-spore production by 25 strains of B. cereus on KG agar were measured. The recovery of food poisoning strains of B. cereus inoculated into nonsterile food slurries was assessed. A comparison of KG agar and mannitol-egg yolk-polymyxin-agar indicated that the two media were comparable in their abilities to recover low levels of B. cereus from naturally contaminated foods. Since KG agar enhances spore formation by B. cereus, thus permitting early serological testing, its use in screening food products is advocated. PMID- 4331769 TI - Clinical evaluation of kethoxal against cutaneous herpes simplex. AB - A 2.5% preparation of kethoxal in cream was compared with the cream placebo for efficacy against cutaneous herpes simplex in a double-blind clinical study. The kethoxal formulation was not significantly more effective than the placebo. This conclusion was based on subjective impressions of the patients, observations by the physicians, and quantitative measurement of herpesvirus recovered from the lesions. It was suggested that the lack of clinical activity, in contrast to the marked activity against experimental infections in laboratory animals, resulted from the fact that high levels of herpesvirus were already present in the skin before symptoms were noted. PMID- 4331770 TI - Recovery of small quantities of viruses from clean waters on cellulose nitrate membrane filters. AB - A method is described for quantitatively recovering small amounts of viruses from large volumes of buffered, distilled water. Development of the method was motivated by the anticipated need for testing large volumes of renovated sewage for viruses. The method consists of adsorbing viruses onto cellulose nitrate membrane filters (0.45 mum pore size) from water containing sufficient Na(2)HPO(4) to produce a molarity of 0.05 and sufficient citric acid to produce a pH of 7, and eluting the adsorbed viruses in 3% beef extract under extended sonic treatment. Complete recovery of poliovirus 1, echovirus 7, and coxsackievirus B3 resulted when less than 100 plaque-forming units were added to 1-liter quantities of water. Recoveries of reovirus 1 were almost as good. Preliminary studies indicate that good recoveries can be made from 25-gal quantities of water. The method described is efficient in waters of high quality and may be useful for recovering viruses in renovated, and perhaps in tap waters, but not in waters containing certain organic matter unless that matter is first removed. PMID- 4331771 TI - Effect of -propiolactone on Sendai virus. AB - The biological properties (infectivity, hemagglutination, hemolysis, cell fusion, neuraminidase) of Sendai virus were dissociated on the basis of sensitivity to beta-propiolactone, by freeze-thawing, by heating at different temperatures, and by adsorption-elution with formalinized chicken erythrocytes. Possible mechanisms whereby beta-propiolactone selectively destroys viral infectivity are discussed. PMID- 4331772 TI - Substitution of milk for serum in the production fo human leukocyte interferon. AB - The presence of serum in suspensions of Sendai-induced human leukocytes is necessary for the synthesis of significant amounts of interferon. Very little interferon is obtained from serum-free suspensions. Cow's milk or milk casein can substitute for serum in the production of high yields of human leukocyte interferon. PMID- 4331773 TI - Dye uptake assay: an efficient and sensitive method for human interferon titration. AB - Currently, human interferon (IF) assays are generally performed by plaque reduction or visual cytopathic effect methods. Both are time-consuming, subjective in interpretation, and, in the case of the latter, relatively insensitive. An adaption of the dye uptake method for human IF titration which uses foreskin-derived fibroblasts and vesicular stomatitis virus is described. This assay is reproducible and sensitive (1 unit = 3 international units). By direct comparison, however, it is somewhat less sensitive than the plaque reduction assay (1 unit = 1.1 international units). This assay is especially recommended for use in needed clinical investigations of human IF because of its technical simplicity, allowing efficient handling of large numbers of specimens. PMID- 4331774 TI - Improved medium for enumeration of Clostridium perfringens. AB - An improved selective medium, Tryptose-sulfite-cycloserine (TSC) agar, for the enumeration of Clostridium perfringens is described. It consists of the same basal medium as Shahidi-Ferguson-perfringens (SFP) agar, but with 400 mug of D cycloserine per ml substituted for the kanamycin and polymyxin. Tolerance of C. perfringens for D-cycloserine, its production of lecithinase, and its ability to reduce sulfite were used as the basis for development of this medium. Comparisons were made between TSC and SFP agars for the recovery of vegetative cells of C. perfringens by using statistical methods. The results showed that TSC allowed virtually complete recovery of most of the C. perfringens strains while inhibiting practically all facultative anaerobes tested. SFP agar allowed a slightly higher rate of recovery of C. perfringens but was found to be much less selective. PMID- 4331776 TI - Chemically defined medium for the growth of Clostridium perfringens. AB - A defined medium which supports growth of Clostridium perfringens at low inoculum levels was developed. Generation time for strain 8797 was 1.5 times greater than previously reported for growth in purged fluid thioglycolate medium. PMID- 4331777 TI - [Concentration and purification of foot-and-mouth disease (FMD) virus by polyethylenglycol (PEG)]. PMID- 4331778 TI - Characteristics of a new poxvirus isolated from Indian buffaloes. PMID- 4331775 TI - Solaniol, a toxic metabolite of Fusarium solani. AB - Fusarium solani M-1-1 isolated from moldy bean hulls produces T-2 toxin, diacetoxyscirpenol, and a new toxic trichothecene, solaniol, in Czapek-Dox peptone medium. PMID- 4331780 TI - Reduction of barbiturate dependence induced by repeated electroconvulsions. PMID- 4331779 TI - Ethanol metabolism in the growing rat. PMID- 4331781 TI - [Enzymatic activity of the synovial fluid]. PMID- 4331782 TI - Silica gel stimulates the hydrolysis of lecithin by phospholipase A. PMID- 4331783 TI - Determination of ionizable acid groups in phosphatidyl glycerophosphate (diphytanyl ether analogue) by proton magnetic resonance spectroscopy. PMID- 4331784 TI - Studies on the biosynthetic pathways of molecular species of lecithin by rat lung slices. PMID- 4331785 TI - The phosphoglucolipid from Pseudomonas diminuta. PMID- 4331786 TI - Changes in lipid composition and osmotic fragility of erythrocytes of hamster induced by heat exposure. PMID- 4331787 TI - Determination of the structure of sphinga-4,8-dienine from oyster glycolipids by gas chromatography and mass spectrometry. PMID- 4331788 TI - Biosynthesis and secretion of steroids by the canine testis. PMID- 4331789 TI - Unusual problems tend to appear in crops. PMID- 4331790 TI - [Adrenal cortex function and its seasonal changes in silver-black foxes (Vulpes fulvus Desm.)]. PMID- 4331791 TI - The phagocytic nature of the retinal pigment epithelium. PMID- 4331792 TI - The effect of phenazine methosulphate on the histochemical demonstration of oxidative enzymes in retinal cultures. PMID- 4331793 TI - Ultrastructure of Trypanosoma cruzi in mouse liver. PMID- 4331794 TI - Schistosoma mansoni: fine structure of cercarial acetabular glands. PMID- 4331795 TI - Cytochemical comparison of distribution of proteins and lipids in axenically vs. monoxenically grown Entamoeba histolytica. PMID- 4331796 TI - Aerobic and anaerobic metabolism in Entamoeba histolytica. PMID- 4331797 TI - Entamoeba histolytica: encystation and cultivation of several isolates. PMID- 4331798 TI - Renin activation in the venous plasma from the involved kidney in the patient with renal hypertension. AB - Measurements of plasma renin activity (PRA) in renal vein blood from the ischemic kidney are reported to be generally higher than from the contralateral kidney. Importance of factors other than renin content of renal venous plasma has not been investigated. Initial rate measurements of angiotensin generation with added excess of homologous renin (Plasma Renin Substrate Activity [PRSA]-20 min) were made in bilateral renal venous plasma from 31 patients suspected of suffering from unilateral renal hypertension. The mean values from the involved vs. the contralateral kidney were 551 vs. 331 ng respectively of angiotensin II equivalents generated per milliliter of plasma per 20 min of incubation. The measurement of maximal angiotensin generation under the same conditions with incubation prolonged to 3 hr (PRSA-180 min), however, were bilaterally equal in renal venous plasma from selected patients with renal hypertension who showed distinct differences in PRSA-20 min and PRA measurements. Prior extraction of plasma lipids did not significantly change the bilateral renal venous PRSA-20 min determinations. Stimulation of endogenous renin release in normal dogs did not change the PRSA determinations. The data suggest strongly the presence of a "renin activating" mechanism in the renal venous plasma from the involved kidney of patients with renal hypertension. PMID- 4331799 TI - Concentrations of idoxuridine in serum, urine, and cerebrospinal fluid of patients with suspected diagnoses of Herpesvirus hominis encephalitis. AB - A reproducible microbiologic assay of microgram quantities of idoxuridine (IDU) in serum, urine, or cerebrospinal fluid is presented. The antiviral assay is not interfered with by type-specific antibody or interferon. During slow intravenous infusions of idox-uridine (4 mg/min) in patients with suspected diagnoses of Herpesvirus hominis encephalitis, the rate of inactivation and/or removal of drug exceeded its administration. During several rapid infusions of idoxuridine (50 mg/min) significant quantities of the drug were found in serum, urine, and cerebrospinal fluid. Idoxuridine is not significantly bound to serum proteins and is not deiodinated in fresh serum or urine in vitro to inactive products (iodouracil, uracil, iodide). It is rapidly excreted into the urine. Inactivation of IDU occurs in tissues. This antiviral assay of IDU in body fluids should be applicable to other viruses and potential antiviral agents. Minimal inhibitory concentrations of IDU for fresh isolates of Herpesvirus hominis (type 1 or 2) were determined. Type 1 herpesviruses' microplaques in baby hamster kidney cell (BHK 21) tissue cultures were sensitive to 2.5-10 mug/0.4 ml. Type 2 macroplaques required 25-50 mug/0.4 ml. This latter characteristic may be an additional biologic marker which may be useful in suggesting type-specificity of herpesvirus isolates. PMID- 4331800 TI - Angiotensin II vascular receptors: their avidity in relationship to sodium balance, the autonomic nervous system, and hypertension. AB - During intravenous administration of varying doses of angiotensin II antibody to anesthetized rats, apparently specific vascular receptors were characterized. These receptors compete with administered antibody to bind circulating angiotensin. This competitive phenomenon was used to evaluate the affinity of these receptors for angiotensin. Apparent vascular receptor affinity was defined by the amount of antibody required to block the blood pressure response to exogenous angiotensin. It was found that this receptor affinity varies directly with sodium intake so that the amount of antibody required to block was eightfold greater in normal animals on a high sodium intake, as compared with those on a low sodium intake. Sodium dependence of receptors was also demonstrated in nephrectomized animals, in desoxycorticosterone (DOC)-treated rats, and in chronic renal hypertension. Thus the observed changes in receptor affinity were usually inversely related to measured endogenous angiotensin II levels. Ganglionic blockade increased antibody requirement eightfold. All of these changes were consistent, with no overlap observed in response of individual animals from different groups. These results may explain the variation in pressor activity of angiotensin associated with changes in salt balance and ganglionic blockade. In general, when sufficient antibody was injected to block the effect of exogenous angiotensin a blood pressure lowering effect was also observed. Two exceptions were the nephrectomized and the one-kidney renal hypertensive animals, in both of which antibody administration had no effect on blood pressure. Additional results suggest that changes in receptor affinity are involved in the pathogenesis of various types of experimental hypertensions because the amount of antibody required to block angiotensin was enhanced in renal (twofold), DOC (fourfold), and genetic (fourfold) hypertension. Accordingly, changes in the affinity of these receptors could be critically involved in normal blood pressure control and in various forms of experimental and clinical hypertension, even when circulating angiotensin II levels are normal. PMID- 4331801 TI - Serum follicular-stimulating hormone and luteinizing hormone as measured by radioimmunoassay correlated with sexual development in hypopituitary subjects. AB - Serum follicular-stimulating hormone (FSH) and luteinizing hormone (LH) as determined by radioimmunoassay, were correlated with sexual development in 29 patients with hypopituitarism (ages 14.2-29.9 yr).16 of 25 idiopathic hypopituitary patients (20 males and 5 females) exhibited some degree of sexual development. Stage III of sexual development or beyond was achieved by 12 of the 16. Of 13 patients with growth hormone (GH), adrenocortical-stimulating hormone (ACTH), and thyroid-stimulating hormone (TSH) deficiency, 8 did not develop beyond stage I. In contrast, five of six patients with GH deficiency without ACTH or TSH deficiency developed to stage III of sexual development or beyond. The mean (+/-sd) serum LH concentration while in stage I (4.3 +/-0.9 mIU/ml) of eight patients (seven males and one female) who developed beyond stage I was significantly (P < 0.005) greater than the mean serum LH concentration (2.3 +/ 0.9 mIU/ml) in nine patients (seven males and two females) who had not developed beyond stage I. Mean serum FSH concentrations were not different. Three of four males with organic hypopituitarism did not develop beyond stage I of sexual development. Serum FSH and LH concentrations in the idiopathic and organic hypopituitary patients were more compatible with stage of sexual development than with age. A serum LH concentration below the range of normal for stage I of sexual development in a prepubertal patient suggests that the patient will remain sexually infantile as an adult. PMID- 4331802 TI - The effects of thrombin on adenyl cyclase activity and a membrane protein from human platelets. AB - Washed human platelets were incubated with 0.1-1.0 U/ml human thrombin and the effects on adenyl cyclase activity and on a platelet membrane protein (designated thrombin-sensitive protein) were studied. Adenyl cyclase activity was decreased 70-90% when intact platelets were incubated with thrombin. The T(1/2) for loss of adenyl cyclase activity was less than 15 sec at 1 U/ml thrombin. There was no decrease of adenyl cyclase activity when sonicated platelets or isolated membranes were incubated with these concentrations of thrombin. Loss of adenyl cyclase activity was relatively specific since the activities of other platelet membrane enzymes were unaffected by thrombin. Prior incubation of platelets with dibutyryl cyclic adenosine monophosphate (AMP), prostaglandin E(1), or theophylline protected adenyl cyclase from inhibition by thrombin. Incubation of intact but not disrupted platelets with thrombin resulted in the release of thrombin-sensitive protein from the platelet membrane. The rapid release of this protein (T(1/2) < 15 sec) at low concentrations of thrombin suggested that removal of thrombin-sensitive protein from the platelet membrane is an integral part of the platelet release reaction. This hypothesis is supported by the parallel effects of thrombin on adenyl cyclase activity and thrombin-sensitive protein release in the presence of dibutyryl cyclic AMP, prostaglandin E(1), and theophylline at varying concentrations of thrombin. PMID- 4331804 TI - Conditions for the estimation of serum lactic dehydrogenase activity using the LKB 3600 reaction rate analyser and the range found in healthy subjects. PMID- 4331803 TI - Mechanism of antidiuretic effect of beta adrenergic stimulation. AB - The effect of beta adrenergic stimulation on renal-diluting capacity was examined in the dog. Beta adrenergic stimulation with intravenous isoproterenol significantly increased urinary osmolality (U(Osm)) and decreased free water clearance (C(H2O)), and these effects were rapidly reversible with cessation of the infusion. This antidiuretic effect of systemic beta adrenergic stimulation was comparable in innervated and denervated kidneys and was not associated with alterations in glomerular filtration rate or renal vascular resistance. Renal perfusion pressure was maintained constant in all of the experiments. The same dose of isoproterenol, which produced the antidiuretic effect and markedly stimulated cardiac beta adrenergic receptors when infused intravenously, was not found either to increase U(Osm) or to decrease C(H2O) when infused directly into the renal artery. Removal of the source of production and release of antidiuretic hormone (ADH) was, however, found to abolish the effect of intravenous isoproterenol on U(Osm). A small effect on C(H2O) persisted and appeared to be related to an increase in arterial hematocrit. Thus, the results of the study exclude a major role of alterations in renal hemodynamics and renal innervation in the antidiuretic response to beta adrenergic stimulation with isoproterenol. They also provide no support for the hypothesis that beta adrenergic stimulation may directly alter the water permeability of the renal tubular epithelium. Rather the results suggest that the primary mechanism of the antidiuretic effect of beta adrenergic stimulation involves the integrity of the hypothalamoneurohypophyial system and the release of ADH. PMID- 4331805 TI - Foetoprotein estimation in the diagnosis of hepatoma. PMID- 4331806 TI - Chest symptomatology in an Egyptian portland cement factory. PMID- 4331808 TI - Buoyant density of picornaviruses in caesium salts. PMID- 4331807 TI - Stepwise degradation of poliovirus capsid by alkaline treatment. PMID- 4331809 TI - Interferon in mice acutely infected with M-P virus. PMID- 4331810 TI - The differentiation of herpes simplex virus type 1 and type 2 by temperature markers. PMID- 4331811 TI - Sequential suppression by actinomycin D of interferon production and cellular resistance induced by Poly I:C. PMID- 4331812 TI - Polynucleotide sequence homologies among the RNAs of foot-and-mouth disease virus types A, C and O. PMID- 4331813 TI - Distinguishing characteristics of the interferon responses of primary and continuous mouse cell cultures. PMID- 4331814 TI - Isolation and properties of a phage receptor substance from the plasma membrane of Streptococcus lactis ML 3. PMID- 4331815 TI - Relationship of the antigenic structure of foot-and-mouth disease virus to the process of infection. PMID- 4331816 TI - Panel discussion. Salivary gland tumours. PMID- 4331817 TI - Capture and handling of wild Norway rats used for endocrine studies. PMID- 4331818 TI - Posture in the management of esophageal atresia: variations on a theme by Dr. E. B. D. Neuhauser. PMID- 4331820 TI - Renal function during the stages of sleep. PMID- 4331819 TI - Ionic permeability changes induced by some cholinergic agonists on normal and denervated frog muscles. AB - 1. The reversal potential of responses to iontophoretic application of acetylcholine, carbamylcholine and decamethonium has been measured at junctional and extrajunctional sensitive areas of the normal sartorius muscle of the frog.2. The values obtained with any one of the drugs at junctional spots were similar to those previously reported for the end-plate potential (about - 16 mV).3. On the other hand, at extrajunctional areas the reversal potential of responses to these agonists was found to have a mean value of - 42 mV. The muscle-tendon responses to acetylcholine reversed at - 51 mV.4. The response to decamethonium was used to determine the nature of the ionic permeability changes mediated by the extrajunctional receptors. The results obtained show that extrajunctional responses are due to an increase in conductance to Na(+) and K(+) but not to Cl( ).5. The reversal potential of acetylcholine responses in denervated frog sartorius was - 42 mV both at former junctional spots and at non-neural sensitized regions.6. These different values of the reversal potential can be due either to effects of receptor density on the ionic selectivity of the membrane or to regional variations in the extracellular ionic accumulation during the transmitter action. PMID- 4331821 TI - Catecholaminergic mechanisms in angiotensin-induced drinking. PMID- 4331822 TI - Inhibition of drinking induced by intracranial angiotensin by ingestion of either isotonic saline or water. PMID- 4331823 TI - Effects of fusimotor stimulation on the sensitivity of muscle spindle endings to small-amplitude sinusoidal stretching. PMID- 4331824 TI - Angiotensin II-like activity in arterial blood in new-born lambs. PMID- 4331825 TI - Electrophysiological estimation of inhibition of acetylcholinesterase with normal transmitter release. PMID- 4331826 TI - Presynaptic effect of tetanus toxin at the neuromuscular junction. PMID- 4331828 TI - Conformation of hydrogen cyanide dimer and its role in chemical evolution. PMID- 4331827 TI - The effect of selective medullary coagulation on the cardiovascular response to intravenous infusion of angiotensin in the rabbit. PMID- 4331829 TI - Adenyl cyclase, phosphodiesterase and cyclic AMP dependent protein kinase of malignant glial cells in culture. PMID- 4331830 TI - [Therapy of thyroid diseases. I. B. Therapy of hyperthyreoses]. PMID- 4331831 TI - [Localization of benz(a)pyrene in bacterial cells]. PMID- 4331832 TI - [Production of Bacillus polymyxa mutants producing the antibiotic polymyxin M using N-methyl-N-nitro-N-nitrosoguanidine]. PMID- 4331833 TI - [Spin-label study of the characteristics of spore activation in Thermoactinomyces vulgaris 2681]. PMID- 4331834 TI - [Trophoblastic disease treated with intravenous application of methotrexate]. PMID- 4331835 TI - Convergence nystagmus in brain stem tuberculoma. PMID- 4331836 TI - Studies on the specificity of the complement fixation test in cytomegalovirus infections. With special reference to possible cross-reactions with other herpesvirus antigens. PMID- 4331837 TI - Congenital smallpox. PMID- 4331838 TI - [Nephroblastoma]. PMID- 4331839 TI - [Examination of persons returning from the tropics for intestinal parasites]. PMID- 4331840 TI - [Alveolar carcinoma of the lung]. PMID- 4331841 TI - A sensitive method for determination of chromium in biological materials. PMID- 4331842 TI - New radiochemical method for assay of inorganic pyrophosphatase. PMID- 4331843 TI - Analytical scanning isoelectrofocusing. 3. Design and operation of an in situ scanning apparatus. PMID- 4331844 TI - Elimination of phosphorus interference in the colorimetric determination of silicon in biological material. PMID- 4331845 TI - Accurate assay of low intestinal lactase activity with a fluorometric method. PMID- 4331846 TI - Inactivation of E. coli alkaline phosphatase prior to phosphodiesterase digestion of oligodeoxyribonucleotides. PMID- 4331847 TI - The determination of nikethamide and other compounds in pharmaceutical dosage forms by thin-layer chromatography. PMID- 4331848 TI - [Morphological model of tympanosclerosis produced by calciphylaxis on the middle ear mucosa in guinea pig]. PMID- 4331849 TI - [Experimental calcinosis of middle-ear mucous membrane in guinea pigs]. PMID- 4331850 TI - Abortive infection of hamster cells by polyoma virus. PMID- 4331851 TI - Effects of lysolecithin (lysophosphatidylcholine) and fatty acids on rat liver microsomal glucose 6-phosphatase. PMID- 4331852 TI - Fatty acids from acylhydrolase action on diglycerides inhibit phospholipase C treated microsomal glucose 6-phosphatase. PMID- 4331853 TI - Deoxyribonucleic acid synthesis in cells infected with type 1 or type 2 herpes simplex virus. PMID- 4331854 TI - Studies on nuclear proteins in cells infected with type 1 or type 2 herpes simplex virus. PMID- 4331855 TI - Induction of deoxyribonucleic acid polymerase and deoxyribonuclease activities in cells infected with herpes simplex virus type II. PMID- 4331857 TI - Light-induced development of enzymes of glycollate metabolism in etiolated bean leaves. PMID- 4331856 TI - Effect of azaserine on insulin in release in vitro. PMID- 4331858 TI - Oestradiol, adenosine 3':5'-cyclic monophosphate and nucleolar ribonucleic acid polymerase in calf endometrium. PMID- 4331859 TI - The specificity of combination between ristocetins and peptides related to bacterial cell wall mucopeptide precursors. AB - The affinity of ristocetin B for analogues of the C-terminal tripeptide sequence of bacterial cell wall mucopeptide precursors resembles that of vancomycin. Complex-formation requires a d-configuration in the two amino acid residues of the C-terminal dipeptide, an l-configuration is preferred in the preceding amino acid residue and positive charges on the peptide molecule decrease its affinity. The specificity of ristocetin B, however, differs from that of vancomycin in the requirements for the size of the side chains on the C-terminal dipeptide. These differences may explain the observed differences in antibiotic behaviour of vancomycin and ristocetin with particular micro-organisms. The optical rotatory dispersion and u.v.-absorption characteristics of the ristocetins are very different from those of vancomycin but nearly identical with those of ristomycin A. Aglycones prepared from ristomycin A were antibiotically active and also combined with a specific peptide. PMID- 4331862 TI - Multiple forms of uridine kinase in normal and neoplastic rat liver. AB - Two species of uridine kinase with molecular weights of approximately 120000 (I) and 30000 (II) have been identified in the rat liver system. Species I predominates in the 7-day postnatal and adult rat liver and increases in the regenerating remnant of the latter after partial hepatectomy; the concentration of species II is low in these tissues. Species I also predominates in the slow growing hepatomas 5123D and 7800. In contrast, II is the predominant form in the foetal rat liver and accounts for 40% of the total activity in the rapidly growing Novikoff ascites hepatoma. In contrast to species II, which was stable, species I was inactivated by preincubation for 30min at 37 degrees C, before assay at 23 degrees C. PMID- 4331861 TI - Nucleoside pyrophosphatase activity associated with pig kidney alkaline phosphatase. AB - 1. A study was made of the hydrolysis, at pH9.0, of ATP and ADP catalysed by pig kidney alkaline phosphatase. Both of these nucleoside pyrophosphates are substrates for the enzyme; K(m) values are 4x10(-5)m for ATP and 6.3x10(-5)m for ADP. V(max.) for ADP is approximately double that of ATP. 2. Above 0.1mm approximately, both ATP and ADP are inhibitory, but the inhibition is reversible by the addition of Mg(2+) ions to form MgATP(2-) or MgADP(-) complexes. The complexes, besides being non-inhibitory, are also substrates for the enzyme with K(m) values identical with those of the respective free nucleotides. 3. Mg(2+) ions are inhibitory when present in excess of ATP or ADP. The degree of inhibition is greater with ATP as substrate, but with both ATP and ADP a mixed competitive-non-competitive type of inhibition is observed. 4. It is suggested that under normal conditions the enzyme is inhibited by cellular concentrations of ATP plus ADP but that an increase in the concentration of Mg(2+) ions stimulates activity by relieving nucleoside pyrophosphate inhibition. The properties may be of importance in the regulation of the transport of bivalent cations. PMID- 4331860 TI - Synthesis of phosphoenolpyruvate from propionate in sheep liver. AB - 1. Utilization of propionate by sheep liver mitochondria was stimulated equally by pyruvate or alpha-oxoglutarate, with formation predominantly of malate. Pyruvate increased conversion of propionate carbon into citrate, whereas alpha oxoglutarate increased formation of phosphoenolpyruvate. The fraction of metabolized propionate converted into phosphoenolpyruvate was about 17% in the presence or absence of alpha-oxoglutarate and about 7% in the presence of pyruvate. Pyruvate consumption was inhibited by 80% by 5mm-propionate. 2. Compared with rat liver, sheep liver was characterized by very high activities of phosphoenolpyruvate carboxykinase and moderately high activities of aconitase in the mitochondria and by low activities of ;malic' enzyme, pyruvate kinase and lactate dehydrogenase in the cytosol. Activities of phosphoenolpyruvate carboxy kinase were similar in liver cytosol from rats and sheep. Activities of malate dehydrogenase and NADP-linked isocitrate dehydrogenase in sheep liver were about half those in rat liver. 3. The phosphate-dicarboxylate antiport was active in sheep liver mitochondria, but compared with rat liver mitochondria the citrate malate antiport showed only low activity and mitochondrial aconitase was relatively inaccessible to external citrate. The rate of swelling of mitochondria induced by phosphate in solutions of ammonium malate was inversely related to the concentration of malate. 4. The results are discussed in relation to gluconeogenesis from propionate in sheep liver. It is proposed that propionate is converted into malate by the mitochondria and the malate is converted into phosphoenolpyruvate by enzymes in the cytosol. In this way sufficient NADH would be generated in the cytosol to convert the phosphoenolpyruvate into glucose. PMID- 4331863 TI - Turnover of the plasma-membrane and microsomal proteins of rat liver containing primary hepatoma nodules. PMID- 4331864 TI - [Differentiation and reactions of the neurohypophyseal pituicytes in conditions of whole-body irradiation]. PMID- 4331865 TI - [Basic protein content in reticular cells of transplantable lines, sensitive and resistant to enteroviruses]. PMID- 4331866 TI - [Cytogenetic characteristics of 2 new transplantable cell lines of the gray hamster (Cricetulus migratorius) transformed by Rous sarcoma virus]. PMID- 4331867 TI - Early and late results of operative treatment of tumors of the acoustic nerve. PMID- 4331868 TI - Cellular immunity: immune responses and the herpes-like virus. PMID- 4331869 TI - Lymphocyte blast transformation. I. Demonstration of adrenergic receptors in human peripheral lymphocytes. PMID- 4331870 TI - Contact and short-range interactions affecting growth of animal cells in culture. PMID- 4331871 TI - An analysis of the mechanism of neoplastic cell transformation by polyoma virus, hydrocarbons, and x-irradiation. PMID- 4331873 TI - [Structural rearrangements in the active center of alpha-chymotrypsin]. PMID- 4331872 TI - Differentiation of connective tissues. PMID- 4331875 TI - Nuclear magnetic resonance studies of metal porphyrins. I. Kinetics of ligand exchange and of transitions between high- and low-spin states in the system hemin pyridine-water. PMID- 4331874 TI - [New puffs induced by cobalt and effect of cobalt on enzymes]. PMID- 4331876 TI - [Irreversible nerve damages after herpes zoster oticus]. PMID- 4331877 TI - [Auriculotemporal syndrome. Report of 4 cases]. PMID- 4331878 TI - Unit inhibitory responses to peripheral and central conditioned stimuli. PMID- 4331879 TI - [Amplitude and variability of monosynaptic reflexes before a voluntary movement]. PMID- 4331880 TI - Effect of atropine on drinking induced by carbachol, angiotensin and isoproterenol. PMID- 4331881 TI - Neurofibromatosis of the mesentery. PMID- 4331882 TI - Tumour ACTH concentrations in ectopic ACTH syndrome and in control tissues. PMID- 4331884 TI - Tibial nerve dysfunction during pregnancy. PMID- 4331883 TI - Leukocyte function in inflammation: the ingestion, killing, and digestion of microorganisms. PMID- 4331885 TI - Tumors of the lacrimal glands: their surgical management. PMID- 4331887 TI - [An aftercare department of a mental hospital with outpatient, day- and night departments]. PMID- 4331886 TI - Surgical grand rounds from the University of Mississippi Medical Center. Management of hyperinsulinism. PMID- 4331888 TI - [Effect of ribonuclease on ascitic cells. I. Reaction ascitic cells]. PMID- 4331889 TI - [Determination of angiotensin in the isolated colon of rats]. PMID- 4331890 TI - [Synthetic depot-ACTH in the treatment of obstructive bronchial diseases]. PMID- 4331891 TI - [Clinical picture of the malignant paranasal sinus neoplasms with special reference to the tomography with multidimensional blur]. PMID- 4331892 TI - [Complications from Kuntscher's nailing]. PMID- 4331893 TI - Comparative study of bovine adenoviruses. PMID- 4331894 TI - Envelopment of infectious bovine rhinotracheitis viral particles in bovine kidney cell cultures: an electron microscopic study. PMID- 4331895 TI - Ultrastructure of the interalveolar septum of the lung of the goat. PMID- 4331896 TI - Electron microscopy of swinepox virus in germfree pigs and in cell culture. PMID- 4331897 TI - Resistance of progeny from parental stock of chickens immunized against Marek's disease. PMID- 4331898 TI - Early induction of resistance in ducklings against virus hepatitis. PMID- 4331899 TI - [Thin layer chromatography of penicillins on silica gel. Semi-quantitative method for the determination of products of phenoxymethyl penicillin inactivation]. PMID- 4331900 TI - [Ultrastructure of benign juvenile melanoma]. PMID- 4331901 TI - [Pathology and clinical aspect of multiple familial glomus tumors]. PMID- 4331902 TI - Radioimmunoassay of angiotensin II in peripheral venous plasma: effects of diet and posture and application to measurement of renal venous renin ratio. PMID- 4331903 TI - Furadantin neuropathy. PMID- 4331904 TI - Peripheral neuropathy caused by drugs and toxic substances. PMID- 4331905 TI - Radioautographic localization of the acetylcholine-stimulated synthesis of phosphatidylinositol in skin from patients with and without cystic fibrosis. PMID- 4331906 TI - Modification of new fluorometric method for serum and urine cortisol. PMID- 4331907 TI - Fine structure and progesterone levels in the corpus luteum of the pig during the estrous cycle. PMID- 4331908 TI - Strange male pregnancy block in deermice: prolactin and adrenocortical hormones. PMID- 4331910 TI - Contact sensitivity in the mouse. V. The role of macrophage cytophilic antibody in passive transfer and the effect of trypsin and anti-gamma globulin serum. PMID- 4331909 TI - Rehabilitation of hemiplegia: indices of assessment and prognosis. PMID- 4331911 TI - [Behavior of adrenal cortex hormones in obesity]. PMID- 4331912 TI - Stimulation by thyrotropin in vitro of uridine incorporation into the RNA of thyroid slices. PMID- 4331913 TI - Ultrastructural modifications of intercellular junctions between tumor cells. PMID- 4331914 TI - Some aspects of somatic cell hybridization. PMID- 4331915 TI - Cellular and viral contributions to maintenance of the SV40-transformed state. PMID- 4331916 TI - Substituted thiazolylureas. PMID- 4331917 TI - Alkylating analogs of peptide hormones. 1. Synthesis and properties of p-(N,N-) bis(2-chloroethyl)amino)phenylbutyryl derivatives of bradykinin and bradykinin potentiating factor. PMID- 4331920 TI - Substituted thiazolidones and their selective inhibition of nicotinamide-adenine dimucleotide dependent oxidations. PMID- 4331918 TI - Potential renin inhibitors. 2. Ethanolamine and ethylamine derivatives of phospholipids. PMID- 4331919 TI - Alkylating analogs of peptide hormones. 2. Synthesis and properties of p-(N,N bis(2-chloroethyl)amino)phenylbutyryl derivatives of angiotensin II. PMID- 4331922 TI - Colony management as applied to disease control with mention of some viral diseases. PMID- 4331921 TI - Viral diseases noted in the Yerkes Primate Center colony. PMID- 4331923 TI - Collection and handling of specimens for detection of infection or disease. PMID- 4331925 TI - Review of some outbreaks of viral disease in captive nonhuman primates. PMID- 4331926 TI - Assay and pathogenesis of oncogeic viruses in nonhuman primates. PMID- 4331927 TI - New herpesviruses from South American monkeys. Preliminary report. PMID- 4331928 TI - The research reagents program of the National Institute of Allergy and Infectious Diseases. PMID- 4331929 TI - A program for surveillance of nonhuman primate disease. PMID- 4331930 TI - B virus vaccine. PMID- 4331931 TI - Use of nonhuman primates for vaccine manufacture and control. PMID- 4331932 TI - The identification of primates used in viral research. PMID- 4331934 TI - Reduction of nonhuman primate viral infection. PMID- 4331933 TI - Viral biology and ecology. PMID- 4331935 TI - Epizootic vesicular disease in macaque monkeys. PMID- 4331936 TI - Possible cytomegalovirus infection in man following chimpanzee bite. PMID- 4331937 TI - Rabies in imported nonhuman primates. PMID- 4331938 TI - Delta Primate Center viral infection losses. PMID- 4331939 TI - Collaborative studies on nonhuman primate virology. PMID- 4331940 TI - Concepts of a nonhuman primate virology workshop. PMID- 4331941 TI - Problems associated with the use of nonhuman primates. PMID- 4331942 TI - [Studies of the SAP (sensory action potential) as a means of documenting in cipient neuropathies in gastrectomized patients]. PMID- 4331943 TI - Release of surface-associated phosphoesterases from HeLa cells. PMID- 4331944 TI - The effect of angiotensin on renin production and release in vitro. PMID- 4331945 TI - Cell-to-cell transmission of herpes simplex virus in primary human amnion cells. PMID- 4331946 TI - Requirement of live Friend leukemia virus for enhanced expression of Hybrid histocompatibility genes. PMID- 4331947 TI - Antiviral activity of tobacco leaf on encephalomyocarditis (EMC) virus infection. PMID- 4331948 TI - Acetate incorporation into lipids of canine lung cells. PMID- 4331949 TI - Erythrocyte diphosphopyridine nucleotidase (NADase) in paroxysmal nocturnal hemoglobinuria. PMID- 4331950 TI - Colonization of lipid-laden cells from aortic intima of cholesterol-fed rabbits. PMID- 4331951 TI - The accumulation of serum lipoprotein cholesterol by tissue culture cells. PMID- 4331952 TI - Fine structure of trypsin-dissociated cells of the rat anterior pituitary gland. PMID- 4331953 TI - [A case of cylindroma of the vagina]. PMID- 4331954 TI - [Heterotopic calcification of the sheath of a peripheral nerve]. PMID- 4331955 TI - [Survival of poliomyelitis, ECHO and Coxsackie viruses in some food products]. PMID- 4331956 TI - Evaluation of metronidazole and MK-910 in invasive amebiasis. PMID- 4331957 TI - Isoproterenol-sensitive adenyl cyclase in a particulate fraction of epidermis. PMID- 4331958 TI - [Ultrastructure of human placental villi in diabetes mellitus]. PMID- 4331959 TI - Sleep and time zone changes. A study in acute sleep reversal. PMID- 4331960 TI - Diphenylhydantoin and ion flux in lobster nerve. PMID- 4331961 TI - Neurological classics. XLI. Parinaud's syndrome. PMID- 4331963 TI - A method for recovering enterovirus from infected samples by adsorption onto shaken suspended cells. PMID- 4331962 TI - The regulation of growth hormone secretion from the isolated rat anterior pituitary in vitro. The role of adenosine 3':5'-cyclic monophosphate. AB - 1. The release of growth hormone from isolated fragments of rat anterior pituitary tissue incubated in vitro was studied by employing a double-antibody radioimmunoassay. 2. In the absence of added stimuli, two phases of hormone release could be distinguished, an early phase of 2h duration and a subsequent late phase. In the early phase, hormone release was rapid but could be significantly decreased by calcium depletion and by 2,4-dinitrophenol whereas the rate of release in the late phase was uninfluenced by these incubation conditions. These results have been interpreted as indicating the existence of a secretory component in the early phase of release. 3. In subsequent experiments, the effects of various agents on the rate of hormone output during the late phase of incubation were investigated. Hormone release was increased by theophylline and by dibutyryl cyclic AMP (N(6)-2'-O-dibutyryl-adenosine 3':5'-cyclic monophosphate), the response to both of these agents being related to the concentration of the stimulant employed. 4. The stimulation of growth hormone output by theophylline was significantly decreased by calcium deprivation and by 2,4-dinitrophenol. The response to dibutyryl cyclic AMP was diminished by 2,4 dinitrophenol, iodoacetate and 2-deoxyglucose but not by malonate or colchicine. 5. Arginine, beta-hydroxybutyrate, albumin-bound palmitate and variation in the glucose concentration of the incubation medium over a wide range were without any statistically significant effect on the rate of hormone release from either control pituitary fragments or those subject to secretory stimulation by dibutyryl cyclic AMP. 6. It is suggested that the regulation of growth hormone secretion is mediated by cyclic AMP (adenosine 3':5'-cyclic monophosphate). The secretion observed in response to cyclic AMP requires the presence of ionized calcium and a source of metabolic energy but is independent of pituitary protein synthesis de novo. The integrity of the glycolytic pathway of glucose metabolism appears to be essential for cyclic AMP-stimulated growth hormone secretion to occur. PMID- 4331964 TI - Cation content and cation-exchange capacity of intact cells and cell envelopes of viomycin-sensitive and -resistant strains of Rhizobium meliloti. PMID- 4331965 TI - Toward a molecular explanation for specific cell adhesion. PMID- 4331966 TI - The biological significance of turnover of the surface membrane of animal cells. PMID- 4331967 TI - Cellular aspects of muscle differentiation in vitro. PMID- 4331968 TI - Macromolecular biosynthesis in animal cells infected with cytolytic viruses. PMID- 4331969 TI - Effects of fluphenazine hydrochloride on digital computer sleep prints of schizophrenic patients. PMID- 4331970 TI - [Radioisotope scanning in the diagnosis of pancreatic diseases]. PMID- 4331971 TI - The effect of plasma cortisol levels on the lymphocyte transformation test. PMID- 4331972 TI - Successful initiation of alternate-day prednisone in chronic steroid-dependent asthmatic patients. PMID- 4331973 TI - Compression of the deep palmar branch of the ulnar nerve by an anomalous muscle. Case report and review. PMID- 4331974 TI - Plasma corticotropin (ACTH), growth hormone (GH), and 11-OHCS (hydroxycorticosteroid) response during surgery. PMID- 4331976 TI - Rapid identification of herpes simplex virus in tissue culture by direct immunofluorescence. PMID- 4331977 TI - Quantitative measures of sensitivity of isolates and concentrations of idoxuridine in body fluids of patients with Herpesvirus encephalitis. PMID- 4331975 TI - Automated chromatographic analysis of acid-soluble red-cell phosphate compounds. PMID- 4331978 TI - Further observations on the role of the adenyl cyclase-cyclic AMP (CAMP) system in human lipolysis. PMID- 4331979 TI - [Studies of separation of oligosaccharides by chromatography on a thin layer of silica gel]. PMID- 4331980 TI - [A mixed uterine tumor in a cow--observations on etiology and differential diagnosis]. PMID- 4331981 TI - [Pathogenesis of virus diseases]. PMID- 4331982 TI - [Measles virus and subacute progressive panencephalitis. Results of virological and histochemical studies of brain tissue cultures from bioptic material]. PMID- 4331983 TI - [Adenovirus type 2 enteritis in infants and young children. Disease outbreak within an institution]. PMID- 4331984 TI - [Adenovirus-related respiratory and enteral infections in childhood]. PMID- 4331985 TI - [The incidence of virus-induced leukoses following immunosuppressive therapy]. PMID- 4331986 TI - [Could pox vaccination be improved? Studies on oral pox vaccination]. PMID- 4331987 TI - [Physical and immunological properties of poliomyelitis viruses]. PMID- 4331988 TI - [Diagnosis of viral infections by means of immunofluorescence]. PMID- 4331989 TI - [Efficiency and value of modern diagnostic methods for cytomegalic inclusion disease]. PMID- 4331990 TI - [The value and limitations of the electroencephalographic hearing test in infants and small children]. PMID- 4331991 TI - [Modern electrodiagnosis of neuromuscular diseases in childhood]. PMID- 4331992 TI - [Method for the differentiation of glycogenoses]. PMID- 4331994 TI - Antiviral activity produced by the polycytidylic acid-hexainosinate system. PMID- 4331993 TI - Lysosomal mechanisms of tissue injury in arthritis. PMID- 4331995 TI - Effect of prostaglandin E 1 on leukocyte migration. PMID- 4331996 TI - Interactions between Marek's disease herpesvirus and avian leucosis virus in tissue culture. PMID- 4331998 TI - [Inflammatory pseudotumor in the lung]. PMID- 4331997 TI - Storage and release of false transmitters after infusion of (+)- and (-)- methyldopamine. PMID- 4331999 TI - [Physiology of the spontaneous motility of isolated renal arteries under the action of various radiologic contrast media]. PMID- 4332000 TI - Parinaud's vertical ophthalmoplegia. PMID- 4332001 TI - Isolation of a Chlamydia-like agent in essential conjunctival atrophy and chronic follicular conjunctivitis. PMID- 4332002 TI - [Klinefelter's syndrome. (Clinical case)]. PMID- 4332003 TI - Specific cleavage of simian virus 40 DNA by restriction endonuclease of Hemophilus influenzae. AB - A bacterial restriction endonuclease has been used to produce specific fragments of SV40 DNA. Digestion of DNA from plaque-purified stocks of SV40 with the restriction endonuclease from Hemophilus influenzae gave 11 fragments resolvable by polyacrylamide gel electrophoresis, eight of which were equimolar with the original DNA. The fragments ranged from about 6.5 x 10(5) to 7.4 x 10(4) daltons, as determined by electron microscopy, DNA content, or electrophoretic mobility. PMID- 4332004 TI - Tetrahedral iron in the active center of plant ferredoxins and beef adrenodoxin. AB - The coordination structure of the iron-sulfur complex in spinach ferredoxin and adrenodoxin is investigated by optical spectroscopy. The circular-dichroism and absorption spectra of these two-iron iron-sulfur proteins reveal weak electronic transitions in the near-infrared wavelength range, 0.8-2.5 mum (12,500-4000 cm( 1)). On the basis of the low absorption intensities and large anisotropy factors, d --> d transitions of the iron can be identified in the reduced proteins at about 4000 cm(-1) and 6000 cm(-1). The low energy of these one-center ligand field transitions, together with the similarity to the ligand-field spectrum of the one-iron protein rubredoxin, leads to the conclusion that the reduced two iron iron-sulfur proteins also contain a high-spin ferrous ion in a distorted tetrahedral site. PMID- 4332005 TI - Chemical induction of focus-forming virus from nonproducer cells transformed by murine sarcoma virus. AB - Focus-forming virus can be induced by chemicals from virus-negative clonal lines of cells transformed by murine sarcoma virus. The viruses activated from such nonproducer cells have the host range and serologic properties of endogenous helper viruses of the cells rather than those of the sarcoma virus used to transform them. The evidence indicates that murine sarcoma virus-transformed nonproducer cells of two species contain the genetic information for both murine sarcoma and helper virus production in an unexpressed form. PMID- 4332006 TI - Virus-specific proteins synthesized in encephalomyocarditis virus-infected HeLa cells. AB - The in vivo synthesis of encephalomyocarditis-specific proteins was studied by labeling the viral proteins with radioactive amino acids under conditions where host-protein synthesis was almost completely inhibited. To assure recovery of all proteins, intact cells were lysed in hot 1% sodium dodecyl sulfate. These lysates were analyzed by quantitative high-resolution electrophoresis on sodium dodecyl sulfate-polyacrylamide gels. This technique allowed the detection and estimation of the molecular weight of 15 virus-specific polypeptides: A, 100,000; B, 90,000; C, 84,000; D, 75,000, D1, 65,000; E, 56,000; epsilon, 40,000; F, 38,000; alpha, 34,000; beta, 30,000; gamma, 23,000; G, 16,000; H, 12,000; I, 11,000; and delta, 9,000. Pulse-chase experiments, in conjunction with cyanogen bromide and tryptic mapping of the isolated polypeptides, indicate that at least three primary gene products (A,F,C), with a cumulative weight of about 220,000, are generated during translation of the RNA genome. Chains A and C then undergo post-translational cleavages, while F remains uncleaved. The proteins generated by the cleavage of A include all of the capsid chains (alpha, beta, gamma, delta, epsilon). Those generated by the cleavage of C include D and E. The chains alpha, beta, gamma, delta, E, F, G, H, I, with a cumulative molecular weight of about 230,000, are stable and are produced in about equimolar amounts. A model for the synthesis of, and a cleavage sequence that accounts for, all of the viral polypeptides is proposed. PMID- 4332007 TI - Karyological properties of human-mouse somatic hybrids. AB - Karyological examinations performed 24 hr to 11 days after Sendai virus-induced fusion of mouse cells of the permanent line 3T3 and human diploid cells, suggest that hybrids with extensive loss of human chromosomes derive from fusion involving all the chromosomes of both parental cells. Examination of 39 independent clones isolated from two different crosses between L mouse cells and cells of two permanent human lines, D98/AH2 and VA2, show that the karyotypes of human-mouse hybrids are a function of the interaction between the parental cells: the mouse chromosomal complement may be doubled or not. For the first time, viable hybrids that have retained almost all of the human chromosomes have been isolated. PMID- 4332008 TI - Genetics of somatic mammalian cells: lethal antigens as genetic markers for study of human linkage groups. AB - The antigen that causes killing of at least 98% of a human cell population treated with a 1% solution of a specific rabbit antiserum in the presence of complement is a sensitive genetic marker. The rapid loss of human chromosomes in human-Chinese hamster cell hybrids makes possible a convenient test of linkage relationships with this marker. Hybrid clones with and without the lethal antigen were isolated and analyzed. In 76 clones and subclones studied, 41 carried both the lethal antigen and the lactic dehydrogenase-A marker, 35 carried neither, and no clones contained only one of the two markers. In contrast to this clear demonstration of linkage, absence of linkage was found between the lethal antigen and the following markers: Lactic dehydrogenase B, NAD-dependent malic dehydrogenase, NADP-dependent malic dehydrogenase, glucose-6-phosphate dehydrogenase, phosphoglucomutase, glutamate oxaloacetate transaminase, indophenol oxidase, glucose phosphate isomerase, proline, inositol, hypoxanthine B, and glycine A. This lethal antigen appears to be carried on a single human autosome. PMID- 4332009 TI - Melatonin metabolism: neural regulation of pineal serotonin: acetyl coenzyme A N acetyltransferase activity. AB - There is a diurnal rhythm in the activity of serotonin N-acetyltransferase in the rat pineal gland. In the normal rat, the nocturnal enzyme activities are 15-to 30 fold greater than are daytime activities. This rhythm is abolished by decentralization or removal of the superior cervical ganglia, procedures that interrupt the only source of central neural input to the pineal gland. This effect of superior cervical sympathectomy on the N-acetyltransferase rhythm cannot be attributed to changes occurring in the denervated pineal parenchymal cells. When chronically denervated glands are placed in organ culture with norepinephrine, the neurotransmitter normally located in sympathetic terminals in the gland, N-acetyltransferase activity increases 10- to 20-fold. These data indicate that superior cervical sympathectomy abolishes the N-acetyltransferase rhythm by elimination of the input of central signals to the gland. These signals appear to regulate the N-acetyltransferase rhythm in the normal rat by regulation of the release of norepinephrine from the sympathetic terminals within the pineal gland. PMID- 4332010 TI - DNA polymerases of tumor virus: specific effect of ethidium bromide on the use of different synthetic templates. AB - The DNA polymerase enzymes from avian, murine, and feline RNA tumor viruses can be distinguished by their ability to read specific, synthetic primertemplates. The copying of templates containing adenylic and thymidylic acids by all these DNA polymerases is inhibited by ethidium bromide, though this compound affects the polymerases from mammalian tumor viruses much more than the enzyme from avian tumor viruses. Conversely, ethidium bromide stimulates the ability of the enzymes from avian tumor viruses to use primertemplates containing only guanylic and cytidylic acids, whereas the mammalian tumor virus enzymes are moderately inhibited. PMID- 4332011 TI - Chemical events in conducting and synaptic membranes during electrical activity. AB - Evidence has accumulated in recent years for the central role of proteins and enzymes in the function of cell membranes. In the chemical theory proposed for the generation of bioelectricity, i.e., for the control of the ion permeability changes of excitable membranes, the protein assembly associated with the action of acetylcholine plays an essential role. Support of the theory by recent protein studies in which the excitable membranes of the highly specialized electric tissue were used will be discussed. A scheme is presented indicating the possible sequence of chemical reactions that change ion permeability after excitation. A sequence of chemical events within the excitable membranes of the synaptic junctions, i.e., within the pre- and postsynaptic membranes, similar to that proposed for the conducting membranes, is presented in a second scheme as an alternative to the hypothesis of the role of acetylcholine as a transmitter between two cells. PMID- 4332012 TI - Persistence of a repressed Epstein-Barr virus genome in Burkitt lymphoma cells made resistant to 5-bromodeoxyuridine. AB - The P3HR-1 line of human lymphoblastoid cells that is Epstein-Barr virus positive was made resistant to 5-bromodeoxyuridine. Epstein-Barr virus-associated antigens, but not virus particles, were produced in P3HR-1(BU) cells maintained on 5-bromodeoxyuridine. However, virus particles did appear within 4 days after removal of the drug. Thymidine kinase activity was limited to P3HR-1(BU) cells producing viral antigen, whereas all control P3HR-1 cells showed thymidine kinase activity regardless of viral antigen synthesis. Cellular DNA in most P3HR-1(BU) cells was made via pathways that did not involve thymidine kinase. In cells having a pathway that involved thymidine kinase, a second DNA of density 1.71 g/cm(3), corresponding to Epstein-Barr virus, was detected.IT WAS CONCLUDED THAT: (a) a repressed Epstein-Barr virus genome persists in P3HR-1(BU) cells that do not contain thymidine kinase, with activation of the viral genome being accompanied by productive infection and the appearance of enzyme, and (b) thymidine kinase activity in P3HR-1(BU) cells could be used as a marker for viral genome expression. PMID- 4332013 TI - Host-gene control of C-type RNA tumor virus: inheritance of the group-specific antigen of murine leukemia virus. AB - Genetic studies were aimed at elucidation of the mechanism of inheritance of the group-specific antigen of the murine leukemia virus. Two approaches have been used. First, a classical Mendelian hybridization experiment was performed with mice of the high-leukemia AKR strain and the low-leukemia C57L strain; the first filial (F(1)) generation hybrids, the second filial (F(2)) generation hybrids, and the backcrosses to the two parental strains. Second, a number of partially inbred lines derived from the F(2) generation of the same cross were used. The results of these studies demonstrate a specific genetic regulation of expression of group-specific antigens. Genes permissive to the expression of the antigen are dominant or semidominant to their nonpermissive alleles. It appears that two dominant genes carried by the AKR strain, but not by the C57L strain, are necessary for the presence of a complete virus; one of these controls the expression of group-specific antigen. PMID- 4332014 TI - A structure of pyridine nucleotides in solution. AB - Re-examination of the structure of pyridine coenzymes in solution by use of the 220-MHz high-frequency nuclear magnetic resonance spectrometer indicates that there is primarily one folded structure that is in rapid equilibrium with an open form. Reduced DPN(+) and reduced analogs of DPN(+) exist predominantly with the B side of the dihydropyridine ring folded against the adenine moiety. (The oxidized coenzymes appear to exist in the same folded structure.) Furthermore, the ribose protons undergo very little conformational change upon reduction of the pyridine ring; this observation strongly suggests a considerable similarity between the folded forms of the oxidized and reduced coenzymes. A model of the folded structure is presented. PMID- 4332015 TI - Inhibition of replication in functional mouse adrenal tumor cells by adrenocorticotropic hormone mediated by adenosine 3':5'-cyclic monophosphate. AB - Adrenocorticotropic hormone (ACTH) inhibited replication in functional adrenal tumor cells with a concomitant stimulation of steroidogenesis and a characteristic change of morphology from a flattened to a spherical type. [(3)H]Thymidine incorporation into DNA was inhibited by about 50% 6 hours after ACTH treatment. Both cyclic AMP and dibutyryl cyclic AMP inhibited [(3)H]thymidine incorporation and caused the characteristic morphological change noted with ACTH. The extent of stimulation of steroidogenesis and the amount of inhibition of [(3)H]thymidine incorporation in response to various doses of ACTH were closely related and both were in parallel with the concentration of cyclic AMP in the cells. Cyclic GMP and cyclic IMP did not inhibit [(3)H]thymidine incorporation significantly, and did not change the morphology of the cells. AMP inhibited [(3)H]thymidine incorporation into DNA and caused the characteristic morphological change. However, AMP did not increase the cyclic AMP content of the cells. CMP, GMP, and UMP showed a significant inhibition of [(3)H]thymidine incorporation into DNA, but the extent of the inhibition was much less than that with AMP. These nucleotides did not change the morphology of the cells. PMID- 4332016 TI - Purification and base composition analysis of phage lambda early promoters. AB - RNA-polymerase of Escherichia coli was allowed to bind to DNA of phage lambda in the absence of precursors. The resulting complex was excised by nuclease digestion and the protected DNA was recovered by phenol-extraction and ethanol precipitation. Acrylamide gel electrophoresis of protected DNA fragments reveals the existence of two distinct oligonucleotide peaks corresponding, respectively, to 45-52 and 7-10 nucleotide residues along with species of intermediate sizes. Peak I molecules have two properties: (a) their existence is dependent on the presence of sigma factor during the initial binding step, and (b) they are considerably enriched in A-T (up to 67%). On the contrary, peak II molecules have the same base composition as DNA of phage lambda, whether obtained in the presence or absence of sigma factor. Peak I molecules are thus believed to contain DNA sequences involved in promoter recognition, whether they are the promoters themselves, adjacent, or related sequences. PMID- 4332017 TI - Mechanism of action of bacitracin: complexation with metal ion and C 55 isoprenyl pyrophosphate. AB - The inhibition by bacitracin of the enzymatic dephosphorylation of C(55) isoprenyl pyrophosphate is abolished by the addition of chelating agents. If, however, the chelating agent is added after a preincubation of bacitracin with a divalent cation and the lipid substrate, then its addition has little effect, indicating that bacitracin, metal ion, and C(55)-isoprenyl pyrophosphate form a complex. Various divalent cations can participate in complex formation, but monovalent cations are ineffective. A direct demonstration of the formation of a complex between the C(55)-isoprenyl pyrophosphate and bacitracin in the presence of metal ions was obtained. Molecular models that show one possible conformation for a complex between bacitracin and the C(55)-isoprenyl pyrophosphate, in which the metal ion acts as a bridge between the two compounds, are presented. PMID- 4332020 TI - Research into the morphology of E. histolytica: observations on the thermo adaptable strain "Messina" by scanning electron microscope. PMID- 4332018 TI - Detection of human and chick nuclear antigens in nuclei of chick erythrocytes during reactivation in heterokaryons with HeLa cells. AB - Inactive nuclei of chick erythrocyte resume RNA synthesis and increase in volume and dry mass in heterokaryons made by virus-induced fusion of human tumor cells (HeLa) with chick erythrocytes. Nuclear growth is due primarily to migration of human macromolecules into the chick nucleus. Human nucleoplasmic antigens were detected in the nucleoplasm and human nucleolar antigens were detected in the nucleoli of reactivated chick erythrocyte nuclei. After some time, chick-specific nucleolar antigens appear in the nucleoli of both the reactivated chick nuclei and the HeLa cellnuclei. The results suggest that human nuclear proteins play an important part in the reactivation of the chick genome. PMID- 4332021 TI - Study of vascularity of tumors of the liver. PMID- 4332019 TI - Base composition differences between avian myeloblastosis virus transfer RNA and transfer RNA isolated from host cells. AB - Using a novel chemical tritium derivative method, we have determined the base composition of 4S RNA isolated from an RNA tumor virus, the avian myeloblastosis virus, and from normal and neoplastic host cells. Extensive differences were detected, particularly with respect to the amount of methylated bases in the viral RNA. The viral 4S RNA, which fulfills the criteria for designation as transfer RNA, appears to be derived from a precursor pool that is different from the precursor population of host-cell 4S RNA. These results are discussed in regard to the possible relationship between transfer RNA of avian mycoblastosis virus and cellular transfer RNA. PMID- 4332022 TI - Combination chemotherapy in the treatment of germ cell tumors containing choriocarcinoma in males and females. PMID- 4332023 TI - Neurotoxic effect of the dithiocarbamate tecoram on the chick embryo. PMID- 4332024 TI - [Hepatoblastomas and hepatocarcinomas in childhood]. PMID- 4332025 TI - [Formation of the egg envelopes and penetration of symbionts in the egg of the insect Ulopa reticulata Fab. (Homoptera Auchenorhyncha)]. PMID- 4332026 TI - [Spermatogenesis of the tick Ornithodorus moubata]. PMID- 4332027 TI - Ultrastructural evidence for the presence of nerve cells in the gastrodermis of Hydra. PMID- 4332028 TI - [Exocytosis in the neural lobe of the hypophysis]. PMID- 4332029 TI - [Morphological aspects of rabbit infraorbital buccal gland]. PMID- 4332030 TI - Endometrial enzymatic defects in sterility. A histochemical study. PMID- 4332031 TI - Cutaneous responses of normal subjects to histolyticin from Entamoeba histolytica. PMID- 4332032 TI - Quinonoid dihydropterin reductase. PMID- 4332033 TI - The apparent induction of thymidylate synthetase by amethopterin. PMID- 4332034 TI - Stabilization of dihydrofolate reductase by inhibitors in vivo and in vitro. PMID- 4332035 TI - Regulation of folate-dependent enzymes. PMID- 4332036 TI - Clinical and bacteriological results with Myambutol. PMID- 4332037 TI - Evaluation of results of chemotherapy in tuberculosis with special consideration of ethambutol. PMID- 4332038 TI - Estimation of the growth of the T 1 strain of Mycoplasma mycoides in tryptose broth by the measurement of lactate dehydrogenase. I. Method. AB - A highly significant correlation coefficient (r = 0.97, n = 18) was found between the concentration of lactate dehydrogenase measurable after the organisms had been disrupted and the concentration of colony-forming units during the logarithmic phase of growth of a broth culture of the T(1) strain of Mycoplasma mycoides var. mycoides. A concentration of 4.60 x 10(-7) milliunits of lactate dehydrogenase for each colony-forming unit was established. This relationship was used to convert the concentration of lactate dehydrogenase in the culture into an estimate of the concentration of viable mycoplasma. The lactate dehydrogenase was estimated by following the oxidation of reduced nicotinamide adenine dinucleotide, in the presence of pyruvate substrate, at 366 nm in a spectrophotometer. The nicotinamide adenine dinucleotide oxidase system probably contributed a small amount of enzyme activity to the test when lactate dehydrogenase was measured in this way. The method has been described and evaluated for the estimation of titers from 10(7) to 5 x 10(9) colony-forming units per ml. PMID- 4332039 TI - Estimation of the growth of the T 1 strain of Mycoplasma mycoides in tryptose broth by the measurement of lactate dehydrogenase. II. Application to vaccine production. AB - The measurement of lactate dehydrogenase activity has been used to evaluate the growth of the T(1) vaccine strain of Mycoplasma mycoides var. mycoides in broth during the production of vaccine. Estimations were made during incubation at 37 C and storage at 4 C. The results were compared with titers of the vaccine obtained by two conventional methods of assessing viability titers: the counting of colonies formed on solid medium and a 50% end point titer found after dilutions were made in broth. The method of measuring lactate dehydrogenase activity allowed the rapid enumeration of organisms during incubation of the culture, but estimations made on vaccine stored at 4 C did not compare well with the two conventional methods of assessing viability. The lactate dehydrogenase activity of the culture has enabled rapid monitoring of the production stages of this vaccine. PMID- 4332040 TI - Use of disposable micro tissue culture plates for antiviral and interferon induction studies. AB - A reproducible test system requiring small amounts of test compound was developed for evaluating antiviral and interferon-inducing activity. In the antiviral experiments, KB cells were grown in disposable polystyrene microplates covered with a standard domestic plastic wrap. Viruses used in the system were types 1 and 2 herpes simplex virus, vaccinia virus, type 3 adenovirus, myxoma virus, pseudorabies virus, type 3 parainfluenza virus, types 1A and 13 rhinovirus, vesicular stomatitis virus, coxsackievirus B, and type 2 poliovirus. Inhibition of viral cytopathogenic effect was the primary criterion of evaluation of antiviral activity. Reduction in cell and supernatant fluid virus titers was used as a secondary means of evaluation. The microplate system was adaptable for determining prophylactic, therapeutic, and inactivating effects against viruses. Mouse L-929 cells were used for the interferon induction studies, with vesicular stomatitis virus utilized as the indicator of interferon activity. Known active compounds evaluated in this microplate system had activity similar to that seen in macro in vitro systems. PMID- 4332041 TI - Interferon production and host resistance to type II avian (Marek's) leukosis virus (JM strain). AB - Interferon production in both susceptible S- and resistant K-line chickens infected with type II leukosis virus of JM strain and turkey herpesvirus was studied. The resistant line of chickens produced higher levels of interferon than did the susceptible with JM virus infection during the experimental period. When both susceptible S-and resistant K-line chicks were vaccinated with turkey herpesvirus, the interferon production was quantitatively similar in the two lines. PMID- 4332042 TI - Preservation of enteroviruses by freeze-drying. AB - A method was developed for freeze-dry stabilization of poliovirus type 3. An ultrafiltration procedure was used to remove salts from infected tissue culture fluid, and the virus was freeze-dried after suspension in an alkaline organic buffer. This method was further tested with other picornaviruses including poliovirus types 1 and 2, coxsackieviruses A9, A20, B2, and B5, echovirus 11, and the encephalomyocarditis virus. Freeze-dried preparations of the poliovirus could be shipped to distant laboratories at ambient temperature with excellent retention of infectivity. Data are presented showing effects of freeze-drying as well as results of exposure to temperatures to 37 C. PMID- 4332043 TI - Clostridium perfringens. I. Sporulation in a biphasic glucose-ion-exchange resin medium. AB - A biphasic culture medium suitable for cultivation and sporulation of Clostridium perfringens, C. botulinum, and C. sporogenes was devised. The medium designed for use in a disposable, compartmented, plastic film container contained peptones, yeast extract, minerals, an anion exchange resin, and glucose in 4% agar as the solid phase and (NH(4))(2)SO(4) and 0.1% agar as the liquid phase. With the biphasic system, it was not necessary to use active cultures as inocula. Growth was at least equal to that obtained in conventional media, and spore production of 9 out of 12 strains of C. perfringens equalled or usually exceeded that of conventional media. PMID- 4332044 TI - Susceptibility of recent isolates of Pseudomonas aeruginosa to gentamicin, polymyxin, and five penicillins, with observations on the pyocin and immunotypes of the strains. AB - The susceptibilities of recently isolated strains of Pseudomonas aeruginosa to gentamicin, polymyxin B, carbenicillin, ampicillin, penicillin G, and two newer penicillins were tested with the inocula-replicating technique by using undiluted and 10(-3) dilutions of the cultures. With either inoculum, polymyxin B was the most active agent, and a comparison with previous data from this laboratory showed that the susceptibility of P. aeruginosa to this antibiotic had not changed over the past 20 years. Gentamicin was nearly as active as polymyxin, all but 2 of the 141 strains tested with the diluted inoculum being inhibited by 6.25 mug/ml or less. AB-2288, an agent resembling carbenicillin, was four times more active than carbenicillin or BLP-1654; the last two were equally active against the 10(-3) inoculum. A more marked inoculum effect was noted with the penicillin analogues tested, the increase in minimum inhibiting concentration with the undiluted culture being eight-fold for carbenicillin and at least 16-fold for AB 2288 and BLP-1654. Pyocin typing and serotyping failed to demonstrate any clearly predominating types. PMID- 4332045 TI - Propagation and purification of high-titer human cytomegalovirus. AB - High-titered yields of human cytomegalovirus (CMV), strain AD 169, were produced in WI-38 cells in large roller bottles. Maximum plaque titers were observed by the 4th day after infection at which time infectivity in the medium was 200 times greater than that associated with the cells. Virus released into the medium was recovered by sedimentation in a sucrose gradient in a continuous-flow centrifuge rotor. Maximal viral infectivity was found at a sucrose concentration of 42%, equivalent to a density of 1.18 g/cm(3). Deoxyribonucleic acid extracted from these preparations was about 80% viral and 20% cellular as judged by equilibrium centrifugation in cesium chloride density gradients. PMID- 4332046 TI - Preparation of type 2 herpes simplex virus complement-fixing antigen. AB - Comparable complement-fixing antigens of type 1 and type 2 herpes simplex virus were produced by extraction of infected African green monkey cells with 0.85% NaCl which was buffered at pH 9.0 with 0.05 m glycine-NaOH. The optimal antigen dilutions were higher in titrations against hyperimmune animal sera than in titrations against human sera. Complement-fixing antibody to type 2 herpes antigen was detected in 5 of 17 sera from healthy humans. PMID- 4332047 TI - Immunochemical studies on blood groups. L. Structures of some oligosaccharides obtained by mild acid hydrolysis of human ovarian cyst blood group A substance. PMID- 4332048 TI - Concepts relating the behavior of biochemical systems to their underlying molecular properties. PMID- 4332049 TI - Inhibition of the effects of thyroxine by 5,5-diphenyl-2-thiohydantoin. PMID- 4332050 TI - Halidohydrolytic conversion of N,N'-bis-(dichloroacetyl)-N,N'-diethyl-1,4 xylylenediamine in rat liver. PMID- 4332051 TI - Mechanism of inhibition of ribonucleoside diphosphate reductase by a-(N) heterocyclic aldehyde thiosemicarbazones. PMID- 4332053 TI - [Antigenic properties of heart valve tissues preserved by different methods]. PMID- 4332052 TI - Lipid composition of nuclear membranes isolated from bovine liver. PMID- 4332054 TI - [Convergence of afferent signals on neurons of the reticular formation of the midbrain]. PMID- 4332055 TI - [Enzymatic bases of the stimulating effect of ACTH on the adrenocortical cell]. PMID- 4332056 TI - Perianal Paget's disease. PMID- 4332057 TI - The isolation of peroxisomes, mitochondria and chloroplasts from leaves of spinach beet (Beta vulgaris L. ssp. vulgaris). PMID- 4332059 TI - Acaudal spinal source of cervical and forelimb inhibition during sleep. PMID- 4332058 TI - Functional non-identity of subunits and isolation of active dimers of D glyceraldehyde-3-phosphate dehydrogenase. PMID- 4332060 TI - [On the diagnosis and therapy of bronchial asthma]. PMID- 4332061 TI - [Synthetic corticotropin (ACTH) in the treatment of asthma]. PMID- 4332063 TI - Primary carcinoma of liver in Udaipur. PMID- 4332062 TI - Free and protein-bound hydroxyproline in human serum. PMID- 4332064 TI - Primary liver cell carcinoma and post-necrotic cirrhosis associated with Australia antigen and alpha-feto protein. (A case report). PMID- 4332065 TI - Current fads and fashions in medicine. PMID- 4332066 TI - Radiotherapy of childhood cancer. PMID- 4332068 TI - Asexual and sexual stages of a malaria parasite in the thrombocytes of Tropidurus torquatus (Iguanidae) infected with Plasmodium tropiduri. PMID- 4332067 TI - Adverse effects of large doses of medroxyprogesterone (MPA) in idiopathic isosexual precocity. PMID- 4332069 TI - Kinetics of incorporation of DNA precursors from ingested bacteria into macronuclear DNA of Paramecium aurelia. PMID- 4332070 TI - Is there selective mating in Tetrahymena during genomic exclusion? PMID- 4332071 TI - [Methylcholanthrene sensitivity of epithelial tissues of the respiratory tract in BALB-c-Cb-Se mice]. PMID- 4332072 TI - The biosynthesis of collagen. 2. PMID- 4332073 TI - Clostridial endometritis. PMID- 4332074 TI - Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 6-1972. PMID- 4332075 TI - Obstructive and inflammatory diseases of the major salivary glands. PMID- 4332076 TI - Arthritis & other rheumatic diseases. I. Introduction. PMID- 4332077 TI - [Electropolygraphic studies of sleep in various forms of epilepsy]. PMID- 4332078 TI - [Therapeutic consequences from the slow growth of cylindroma and their metastasis]. PMID- 4332079 TI - Immunisation against Newcastle disease in the presence of Marek's disease virus. PMID- 4332081 TI - [Wilms' tumor in an adult]. PMID- 4332080 TI - [Oxidative phosphorylation and the activity of mitochondrial enzymes in different regions of animal brains following repeated electro-convulsive seizures]. PMID- 4332082 TI - [The combined action of ionizing radiation and carcinogens]. PMID- 4332083 TI - [The histologic structure of benign giant cell synoviomas]. PMID- 4332084 TI - [Stimulation of viral carcinogenesis with Freund's adjuvant]. PMID- 4332085 TI - [The state of the thyroid gland and tumor resistance of rats following administration of a minimal blastomogenic dose of strontium-90]. PMID- 4332086 TI - [Chemodectoma of the anterior mediastinum]. PMID- 4332087 TI - [Mixed breast tumor (case report)]. PMID- 4332088 TI - [Primary lung tumors in children]. PMID- 4332089 TI - [Angiographic differential diagnosis of liver and splenic diseases]. PMID- 4332090 TI - [Results of postoperative treatment of glioblastoma multiforme with a radiation sensitizing substance (5-bromo-2-deoxyuridine)]. PMID- 4332091 TI - Mediastinoscopy: a critical evaluation of 220 cases. PMID- 4332092 TI - [Localization of microbodial enzymes in Polytomella caeca]. PMID- 4332094 TI - [Influencing the dormant metabolism of Phycomyces blakesleanus sporangiospores]. PMID- 4332093 TI - Thiobacillus denitrificans as an obligate chemolithotroph. II. Cell suspension and enzymic studies. PMID- 4332095 TI - Demonstration of NADH-ferredoxin reductase in two caccharolytic Clostridia. PMID- 4332096 TI - Hydrazine as an electron donor to the water-oxidation site in photosynthesis. PMID- 4332097 TI - The properties of parsley ferredoxin and its selenium-containing homolog. PMID- 4332098 TI - Studies of the electron transport chain of extremely halophilic bacteria. V. Mode of action of salts on cytochrome oxidase. PMID- 4332099 TI - A simple method for the purification of the mitochondrial NADH dehydrogenase. PMID- 4332100 TI - The purification of cardiac myofibrils with Triton X-100. PMID- 4332101 TI - Respiratory control in Azotobacter vinelandii membranes. PMID- 4332102 TI - The respiratory system of the aerobic, nitrogen-fixing, gram-positive bacterium, Mycobacterium flavum 301. PMID- 4332104 TI - Biochemical studies of the chromaffin granule. II. Properties of membrane-bound and water-soluble forms of chromogranin A and dopamine- -hydroxylase activity. PMID- 4332103 TI - Biochemical studies of the chromaffin granule. I. Distribution of chromagranin A and dopamine- -hydroxylase activity in the membrane and water-soluble granule fractions. PMID- 4332105 TI - [Processes of hydroxylation and peroxide formation in microsomes]. PMID- 4332106 TI - [Extracellular RNAase of Penicillium brevicompactum]. PMID- 4332107 TI - [Synthesis and some characteristics of phosphorus derivatives of natural imidazole-containing dipeptides]. PMID- 4332108 TI - Excitatory and inhibitory interactions in localized populations of model neurons. AB - Coupled nonlinear differential equations are derived for the dynamics of spatially localized populations containing both excitatory and inhibitory model neurons. Phase plane methods and numerical solutions are then used to investigate population responses to various types of stimuli. The results obtained show simple and multiple hysteresis phenomena and limit cycle activity. The latter is particularly interesting since the frequency of the limit cycle oscillation is found to be a monotonic function of stimulus intensity. Finally, it is proved that the existence of limit cycle dynamics in response to one class of stimuli implies the existence of multiple stable states and hysteresis in response to a different class of stimuli. The relation between these findings and a number of experiments is discussed. PMID- 4332109 TI - Basic concepts of ultrastructural neuroanatomy. PMID- 4332110 TI - Approach to diagnosis and treatment of herpes simplex encephalitis. A report of two cases. PMID- 4332111 TI - The lipid composition of the cerebral hemisphere of the miniature pig (Sus scrofa) during development. PMID- 4332112 TI - Effect of propylthiouracil feeding on glycogen metabolism and malic enzyme in the liver of the chick (Gallus domesticus). PMID- 4332114 TI - [Herpes genitalis and cervix carcinoma: a current problem in virus and cancer research]. PMID- 4332113 TI - Collagenolytic activity in some snake venoms. PMID- 4332115 TI - Effects of metabolic inhibitors on responses to serotonin and angiotensin on isolated sheep umbilical arteries. PMID- 4332116 TI - The total structure of viomycin, a tuberculostatic peptide antibiotic. PMID- 4332118 TI - Dissociation between compensatory renal growth and induction of (Na+ + + K + ) ATPase in rat kidney after uninephrectomy. PMID- 4332119 TI - A hypothesized unifying mechanism in neural function. PMID- 4332117 TI - Alterations of free amino acids concentrations in cat brain induced by rapid eye movement sleep deprivation. PMID- 4332120 TI - Influences of cell cycle on uptake of SV40-DNA by diploid human cells. PMID- 4332121 TI - Passive hemagglutination of Herpesvirus hominis. PMID- 4332122 TI - Quantitative determination of phospholipids. PMID- 4332124 TI - Isoniazid & nicotinamide adenine dinucleotide synthesis in Mycobacterium tuberculosis. PMID- 4332123 TI - Mode of action of oral hypoglycaemic agents. II. Sulphonylureas & biguanides in rats. PMID- 4332125 TI - Enzymic formation of squalene homologs from farnesyl Pyrophosphate homologs. PMID- 4332126 TI - Synthesis of uridine diphosphate glucose pyrophosphorylase during the development of Dictyostelium discoideum. PMID- 4332127 TI - Physical and chemical properties of reversibly inactivated lactate dehydrogenases. PMID- 4332128 TI - Nicotinic acid metabolism. 8. Tracer studies on the intermediary roles of methyleneglutarate, methylitaconate, dimethylmaleate, and pyruvate. PMID- 4332129 TI - Comparative fractionation studies of cartilage proteinpolysaccharides. PMID- 4332130 TI - The isolation and characterization from Escherichia coli of an adenosine triphosphate-dependent deoxyribonuclease directed by rec B, C genes. PMID- 4332131 TI - Fructose 1,6-diphosphatase from rabbit liver. XIV. The sequential binding of substrate and cation to the enzyme in the catalytic process. PMID- 4332132 TI - Chromatographic separation of milk proteins: a review. PMID- 4332133 TI - Polarization of tryptophan fluorescence from single striated muscle fibers. A molecular probe of contractile state. AB - Instrumentation has been developed to detect rapidly the polarization of tryptophan fluorescence from single muscle fibers in rigor, relaxation, and contraction. The polarization parameter (P( perpendicular)) obtained by exiciting the muscle tryptophans with light polarized perpendicular to the long axis of the muscle fiber had a magnitude P( perpendicular) (relaxation) > P( perpendicular) (contraction) > P( perpendicular) (rigor) for the three types of muscle fibers examined (glycerinated rabbit psoas, glycerinated dorsal longitudinal flight muscle of Lethocerus americanus, and live semitendinosus of Rana pipiens). P( perpendicular) from single psoas fibers in rigor was found to increase as the sarcomere length increased but in relaxed fibers P( perpendicular) was independent of sarcomere length. After rigor, pyrophosphate produced little or no change in P( perpendicular), but following an adenosine triphosphate (ATP) containing solution, pyrophosphate produced a value of P( perpendicular) that fell between the contraction and relaxation values. Sinusoidal or square wave oscillations of the muscle of amplitude 0.5-2.0% of the sarcomere length and frequency 1, 2, or 5 Hz were applied in rigor when the myosin cross-bridges are considered to be firmly attached to the thin filaments. No significant changes in P( perpendicular) were observed in either rigor or relaxation. The preceding results together with our present knowledge of tryptophan distribution in the contractile proteins has led us to the conclusion that the parameter P( perpendicular) is a probe of the contractile state of myosin which is probably sensitive to the orientation of the myosin S1 subfragment. PMID- 4332134 TI - Trypsin action on the growth of Sendai virus in tissue culture cells. I. Restoration of the infectivity for L cells by direct action of tyrpsin on L cell borne Sendai virus. AB - Sendai virus grown in fertile eggs (egg Sendai) infects L cells in which the synthesis of L Sendai (grown in L cells) occurs by the one-step mechanism. L Sendai is not infectious for L cells when tested by the tube titration method although it is infectious for chick embryos. When L cells infected with egg Sendai were dispersed by trypsin and plated on a monolayer culture of L cells, the viral agents spread to the adjacent recipient cells in which the synthesis of L Sendai occurred. The newly infected L cells became infectious for L cells again by trypsin treatment. Kinetic experiments suggested that the target of trypsin is the mature virus, of L Sendai nature, just budding from the L-cell surface. By using an immunofluorescent cell-counting technique, recovery of the infectivity of L Sendai for L cells due to a direct enzymatic action of trypsin was demonstrated. Under the optimal condition, the infectivity increased 1,000-fold for L cells and 10-fold for chick embryos, and both the titers could favorably be compared. No increasing effect of trypsin was observed on the infectivity of egg Sendai. Density centrifugation studies revealed a difference between egg Sendai and L Sendai in the density. Trypsin treatment which induced the maximal enhancement of L Sendai infectivity did not affect both the densities, showing that variations of Sendai virus in the infectivity for L cells and in the density are independent types of host-controlled modification. PMID- 4332135 TI - Ribonuclease-sensitive deoxyribonucleic acid polymerase activity in uninfected rat cells and rat cells infected with Rous sarcoma virus. AB - Rat cells infected with the B77 strain of avian sarcoma virus [R(B77) cells] produced no virus-like particles but contained information for the production of infectious B77 virus. (3)H-labeled deoxyribonucleic acid (DNA) product of the B77 virus endogenous DNA polymerase system was used to determine the relative amounts of B77 virus-specific ribonucleic acid (RNA) in B77 virus-infected chicken and R(B77) cells. R(B77) cells were found to contain much less B77 virus RNA than did B77 virus-infected chicken cells. Ribonuclease-sensitive DNA polymerase activity was present in high-speed pellet fractions from Nonidet extracts of B77 virus infected rat cells. Similar preparations from some uninfected rat cells contained lesser amounts of a similar ribonuclease-sensitive DNA polymerase activity. The endogenous template for the DNA polymerase activity in high-speed pellet fractions from R(B77) cells was not related to B77 virus RNA or to RNA of a rat C type virus. The DNA product of the endogenous DNA polymerase in high-speed pellet fractions of R(B77) cells hybridized to a small extent with RNA from the same fraction and to a similar extent with RNA from uninfected rat cells. PMID- 4332136 TI - Inhibition of the synthesis of simian virus 40 antigens in cells preinfected with Yaba tumor virus. AB - The synthesis of tumor and viral antigens after infection of an established line of cynomolgus monkey kidney cells with simian virus 40 (SV40) was compared in cells previously infected with Yaba virus and in cells not preinfected. SV40 failed to induce synthesis of tumor or viral antigens in cells preinfected with Yaba virus. The inhibitory state in preinfected cells was shown to develop sequentially. Increase in the rate of deoxyribonucleic acid synthesis in the nuclei of preinfected cells occurred after infection with SV40. This rate of increase was significantly lower than that which occurred in SV40-infected cells which had not been preinfected. Cytosine arabinoside did not exert significant effect on the development of the inhibitory effect against SV40 in Yaba virus infected cells. PMID- 4332137 TI - Regulation of protein synthesis in HeLa cells. 3. Inhibition during poliovirus infection. AB - The mechanism of inhibition of host cell protein synthesis by poliovirus has been studied by examining the behavior of host polyribosomes and polyribosome associated messenger ribonucleic acid (mRNA). Virus infection appears to result in a specific inhibition of the initiation of translation of host cell mRNA. The site of inhibition does not appear to be mRNA itself. Human cells respond to virus infection by producing a factor antagonistic to the virus inhibition which promotes the initiation of host mRNA translation. The production of the host factor is sensitive to actinomycin; however, the behavior of the host cell factor and that of host mRNA appear distinctly different. PMID- 4332138 TI - Rescue of murine sarcoma virus from a sarcoma-positive leukemia-negative cell line: requirement for replicating leukemia virus. AB - The nature of murine sarcoma virus (MSV) "defectiveness" was investigated by employing an MSV-transformed mouse 3T3 cell line which releases noninfectious virus-like particles. Rescue kinetics of MSV, observed after murine leukemia virus (MuLV) superinfection of these "sarcoma-positive leukemia-negative (S + L )" mouse 3T3 cells, consisted of a 9- to 12-hr eclipse period followed by simultaneous release of both MSV and MuLV with no evidence for release of infectious MSV prior to the production of progeny MuLV. Addition of thymidine to the growth medium of MuLV-superinfected S + L - cells at a concentration suppressing deoxyribonucleic acid synthesis inhibited the replication of MuLV and the rescue of MSV. MSV production closely paralleled MuLV replication under a variety of experimental conditions. These results suggest that replication of MuLV is required for the rescue of infectious MSV from S + L - cells and that one (or more) factor, produced late in the MuLV replicative cycle, is utilized by both viruses during virion assembly. During the course of these experiments, virus stocks were recovered which contained infectious MSV in apparent excess over MuLV. These stocks were used for generating new S + L - cell lines by simple end point dilution procedures. PMID- 4332139 TI - Nature of transient inhibition of deoxyribonucleic acid synthesis in HeLa cells by parainfluenza virus 1 (Sendai). AB - Adsorption of ultraviolet-inactivated Sendai virus, at high or low multiplicity, to HeLa cells caused a transient increased incorporation of (3)H-thymidine into the cellular deoxyribonucleic acid (DNA). In HeLa cells synchronized by a double thymidine block, this increased incorporation of thymidine during the S phase lasted from about 30 to 90 min after virus adsorption. The observations that the kinetics of accumulation of radioactive thymidine in the nucleotide pool did not differ in control and in the virus-treated cells and that the (32)P incorporation into the DNA of the virus-treated cells was inhibited at the same time indicate that the augmented incorporation of (3)H-thymidine into DNA results from a transient block in the endogenous pathway of thymidine synthesis. Chromatographic analysis of the nucleotide pool of the virus-treated cells labeled with (14)C formate indicates that methylation of deoxyuridine monophosphate to thymidine monophosphate is inhibited. It is suggested that the inhibition is caused by a block of either the thymidilate synthetase or some step in the tetrahydrofolate cycle. PMID- 4332140 TI - Characterization of the subunit structure of the ribonucleic acid genome of influenza virus. AB - Ribonucleic acid extracted from influenza virus was labeled at the 3' termini with (3)H and analyzed by polyacrylamide gel electrophoresis. Influenza virus was found to contain a minimum of seven and possibly as many as 10 polynucleotide chains, most of which appear to terminate at the 3' end in uridine. PMID- 4332141 TI - Integration of simian virus 40 deoxyribonucleic acid into the deoxyribonucleic acid of primary infected Chinese hamster cells. AB - Simian virus 40 deoxyribonucleic acid (DNA) became associated in an alkaline stable form with the DNA of Chinese hamster embryo cells at 15 to 20 hr post infection, at the time when cell DNA synthesis and T antigen were induced. The integration process was not inhibited by d-arabinosyl cytosine and was only partially inhibited by cycloheximide. PMID- 4332142 TI - Quantitative binding of 125 I-concanavalin A to normal and transformed cells. AB - We have measured the quantitative binding of the radioactively labeled agglutinin (125)I-concanavalin A to normal mammalian cells and simian virus 40- and polyoma virus-transformed cells from tissue culture. Parallel measurements of the amount of (125)I-concanavalin A necessary to cause agglutination of the cells in suspension were carried out. The transformed and nontransformed cells used for these experiments show large differences in their ability to be agglutinated by (125)I-concanavalin A. However, these cell lines have the same number of specific binding sites and similar affinities for the agglutinin whether transformed, trypsinized, or nontransformed. We conclude that the differential capacity of concanavalin A to agglutinate transformed cells relative to normal cells does not result from differences in the number of binding sites between the two types of cells. PMID- 4332143 TI - Deoxyribonucleic acid polymerase of Rous sarcoma virus: reaction conditions and analysis of the reaction product nucleic acids. AB - Reaction conditions for Rous sarcoma virus ribonucleic acid (RNA)-instructed deoxyribonucleic acid (DNA) polymerase activity are described whereby the viral RNA is relatively protected from endogenous or added nuclease activity. Three analyses of reaction product nucleic acids ((3)H-RNA, (32)P-DNA) were compared, namely, gel electrophoresis, Cs(2)SO(4) gradient centrifugation, and hydroxyapatite column chromatography. It was found that hydroxyapatite analysis could be misleading unless the state of the template RNA was monitored concomitantly with the DNA analysis. Gel electrophoresis and Cs(2)SO(4) gradient centrifugation gave comparable results. It was concluded that analyses of the product of reverse transcriptase reactions should not only refer to the template RNA and product DNA species, but also be performed with virus or viral RNA which do not have or obtain nicks in the 60S RNA. Otherwise, interpretation of the results would have the ambiguity of potential artifacts caused by those degraded RNA molecules. PMID- 4332144 TI - Chromatographic separation and antigenic analysis of proteins of the oncornaviruses. I. Avian leukemia-sarcoma viruses. AB - Gel filtration of avian tumor virus proteins in 6 m guanidine hydrochloride clearly resolved seven major protein species. The antigenic activity of these proteins was recovered in good yield after removal of the denaturing solvent, permitting a correlation of specific polypeptides with the principal antigens of the virion. Two of the proteins, of molecular weights 70,000 and 32,000, contain carbohydrate and are situated on the viral membrane, as shown by their being accessible in the intact virus to specific antibodies. Four proteins, with molecular weights (in guanidine) of 27,000, 19,000, 15,000, and 12,000, have different group-specific (gs) antigens and are enclosed within the viral membrane. The smallest protein, with a molecular weight of 10,000, has not previously been described; it is not detectable with antisera and possesses a mobility identical to that of one gs protein when subjected to electrophoresis in polyacrylamide gels in the presence of sodium dodecyl sulfate. Of the proteins lacking carbohydrate, three are present in the virion in a molecular ratio of 2:2:1, and the two others, present in almost equal amount, are rich in lysine and arginine. PMID- 4332145 TI - Entry of vesicular stomatitis virus into L cells. AB - Early stages of the entry of vesicular stomatitis (VS) virus into L cells were followed by electron microscopy with the aid of ferritin antibody labeling. Cells which were infected at 0 C and incubated for 10 min at 37 C were reacted first with antiviral-antiferritin hybrid antibody and then with ferritin or fluorescein labeled apoferritin. Extensive ferritin labeling of the cell surface was detected by both electron and fluorescence microscopy. The labeled regions of the cell surface were continuous with and indistinguishable from the rest of the host cell membrane, suggesting incorporation of viral antigens into the cell surface during viral penetration. Fusion of parental viral membrane with host cell membrane was further demonstrated by examining the localization of (3)H-labeled viral structural proteins in cells infected at 0 C and incubated for short periods at 37 C. Viral nucleoprotein was found in a soluble fraction of the cells which was derived primarily from the cytoplasm, whereas a particulate fraction from the cells was enriched in viral envelope proteins. Cytoplasmic membrane was isolated from these cells, and this membrane contained viral envelope proteins. These results suggest that penetration by VS virus occurs by fusion of the viral and cellular membranes followed by release of nucleo-protein into the cytoplasm. PMID- 4332146 TI - Separation of the infectious ribonucleic acid of potato spindle tuber virus from double-stranded ribonucleic acid of plant tissue extracts. AB - The infectious ribonucleic acid (RNA) of potato spindle tuber virus (PSTV) can be separated by hydroxyapatite chromatography from double-stranded RNA detectable in low amounts in both infected and uninfected plant tissue extracts. The chromatographic behavior of ribonuclease-sensitive PSTV RNA resembles that of transfer RNA. PMID- 4332147 TI - Separation of reticuloendotheliosis virus from avian tumor viruses. AB - Velocity sedimentation and isopycnic density gradient centrifugation indicate that reticuloendotheliosis virus has a different mass and buoyant density than members of the avian tumor virus group. The group-specific antigen of the avian tumor virus group was not detected in concentrated and purified reticuloendotheliosis virus preparations. PMID- 4332149 TI - Reindeer in biomedical research. PMID- 4332148 TI - Specific inhibition of mammalian ribonucleic acid C-type virus deoxyribonucleic acid polymerases by rat antisera. AB - Inhibition of the ribonucleic acid (RNA)- and deoxyribonucleic acid (DNA) dependent DNA polymerase activities of mammalian C-type viruses was obtained with sera from rats bearing murine leukemia virus-induced transplant tumors. Polymerase activities of nonmammalian (viper) C-type virus and murine mammary tumor virus were not inhibited by such sera nor by serum from a rat immunized with the DNA polymerase of feline leukemia virus purified by isoelectric focusing. The latter serum appeared to inhibit preferentially the DNA-dependent DNA polymerase activity of mammalian C-type viruses showing no inhibition of RNA dependent DNA synthesis. PMID- 4332150 TI - Demodectic mange in the golden hamster. PMID- 4332151 TI - Antibody in wild animal (African) sera to human and simian viruses. PMID- 4332152 TI - Observations on shigellosis and development of multiply resistant Shigellas in Macaca mulatta. PMID- 4332153 TI - Circling in mice caused by Pseudomonas aeruginosa. PMID- 4332154 TI - Sequential pathogenicity of Mycoplasma pulmonis in laboratory rats. PMID- 4332155 TI - Bronchiectasis in rats infected with Mycoplasma pulmonis: an electron microscopy study. PMID- 4332156 TI - Canine, feline, and laboratory primate dry feeds: guidelines to evaluation. PMID- 4332157 TI - Pseudopregnancy in the New Zealand white rabbit: necropsy findings. PMID- 4332158 TI - 51-chromium-labeled erythrocyte half-time in rhesus monkeys (Macaca mulatta). PMID- 4332160 TI - Reproduction and survival of short-tailed shrews (Blarina brevicauda) in captivity. PMID- 4332159 TI - Some clinical and microbiological findings in vervet monkeys (Cercopithecus aethiops pygerythrus). PMID- 4332163 TI - A self-feeding device for infant baboon liquid diets. PMID- 4332161 TI - A debilitating fatal murine dermatitis. PMID- 4332162 TI - Serum levels of vitamin B 6 in hypercholesterolemic rhesus monkeys on prophylactic isoniazid. PMID- 4332164 TI - A controlled-running wheel for small animals. PMID- 4332165 TI - The leukocytic component of guinea pig milk. PMID- 4332166 TI - Intravenous injection with a pulsed dental cleaning device. PMID- 4332167 TI - Normal serum biochemical values of Macaca arctoides, Macaca fascicularis, and Macaca radiata. PMID- 4332168 TI - A study of automatic detergent dispensers. PMID- 4332169 TI - Procedure for the maintenance of stable laboratory mouse populations. PMID- 4332170 TI - Comparative blood values in several species of nonhuman primates. PMID- 4332171 TI - An anal cup for rats in metabolic studies involving radioactive materials. PMID- 4332172 TI - Chronic pododermatitis in guinea pigs, a case report. PMID- 4332173 TI - Klebsiella-Enterobacter infections in chimpanzees. PMID- 4332174 TI - Spontaneous abortions in Macaca mulatta. PMID- 4332175 TI - Cyclic AMP formation in human brain: an in vitro stimulation by neurotransmitters. PMID- 4332176 TI - [Virological studies of infection of cattle with the urticaria virus (IBR-IPV virus)]. PMID- 4332177 TI - [Influence of running on the 11-hydroxycorticosteroid concentration in porcine plasma]. PMID- 4332178 TI - Specific inactivation of ribosomes by colicin E3 in vitro and mechanism of immunity in colicinogenic cells. PMID- 4332179 TI - Relationship between conformationally sensitive probe binding sites on phosphorylase b. PMID- 4332180 TI - Human carcinoma antigens cross reacting with anti-embryonic antibodies. PMID- 4332181 TI - Advances in the treatment of virus diseases. PMID- 4332183 TI - Modern views on pharmacology. X. Angiotensin, kinins and prostaglandins. PMID- 4332184 TI - [Fundamental physiopathological mechanisms of peripheral nerve diseases]. PMID- 4332185 TI - [Peripheral neuropathies]. PMID- 4332186 TI - [Recent progress in the study of peripheral neuropathies]. PMID- 4332187 TI - [Progress in the treatment of peripheral nerve lesions]. PMID- 4332188 TI - [Recent acquisitions in virological research]. PMID- 4332189 TI - [Study of the ultrastructure of cells of the 37 RC line infected with poliovirus]. PMID- 4332190 TI - Rehabilitation of amputees following malignant tumours. PMID- 4332191 TI - The influence of experimentally induced hepatotoxicity on the pressor responses to vasoactive substances in beagle dogs. PMID- 4332192 TI - [Stabile fixation in intertrochanteric osteotomy]. PMID- 4332193 TI - [Pathological-anatomical principles in malformed extremities on the example of the fingers]. PMID- 4332194 TI - [Carrier state and excretion of adenovirus (CELO) in chickens]. PMID- 4332195 TI - [Oral immunization against pox. 2. Combined oral vaccination against fowl pox and Newcastle disease]. PMID- 4332196 TI - [Some characteristics of proteolytic systems of Cl. perfringens type A]. PMID- 4332197 TI - [Herpetic encephalitis]. PMID- 4332198 TI - Effect of substrates on electrophoretic mobility of the enzyme: some possible applications. PMID- 4332199 TI - Determination of inorganic phosphate in the presence of interfering amines and nonionic detergents. PMID- 4332200 TI - Cerebellum and atonia of the desynchronized phase of sleep. PMID- 4332201 TI - [The bioelectrical and behavioral differences between the sleep of 1-year-old infants in normal environments and in foundling hospitals]. PMID- 4332202 TI - Insulinoma of the pancreas. Use of the tolbutamide test, arteriography, and selenium scan in modern diagnosis. PMID- 4332203 TI - Lymphatic metastasis in experimental cecal cancer. Effectiveness of lymph nodes as barriers to the spread of tumor cells. PMID- 4332204 TI - Different effect of chlorpromazine on the activity of crystalline lactic dehydrogenase isoenzymes. PMID- 4332205 TI - Inhibition of cyclic 3',5'-adenosine monophosphate phosphodiesterase by substituted imidazopyrazines. PMID- 4332206 TI - Release of creatine phosphokinase from muscle. I. Effect of polymyxin B, compound 48-80, and serotonin. PMID- 4332207 TI - Metabolism of 6-methylthiopurine ribonucleoside 5'-phosphate. PMID- 4332208 TI - Mechanism of the phosphorylation of thymidine by the culture filtrate of Clostridium perfringens and rat liver extract. PMID- 4332209 TI - Abiological synthesis of adenosine di- and triphosphate using recoiled 31 P atoms obtained from the -decay of 31 Si. PMID- 4332211 TI - [Structure of pyruvate dehydrogenase complex of pig heart muscle]. PMID- 4332210 TI - Enzymatic synthesis and properties of 8-bromoguanylic acid oligomers. PMID- 4332212 TI - Protein kinase activity from lactating bovine mammary gland. PMID- 4332213 TI - Synthesis of D-ribitol 5-phosphate by an inorganic pyrophosphate-ribitol phosphotransferase activity of microsomal glucose-6-phosphatase. PMID- 4332214 TI - Angiotensin-converting enzyme from guinea pig and hog lung. PMID- 4332215 TI - Nucleotide inhibition of UDPglucose 4 4 -epimerase from Saccharomyces fragilis and from goat liver. PMID- 4332216 TI - Dipeptidyl carboxypeptidase from Coryne bacterium equi. PMID- 4332217 TI - [Study of the active center of lactate dehydrogenase by the method of paramagnetic labels]. PMID- 4332218 TI - [Effect of inactivating factors on the EPR signal and reduction of the iminoxyl radical in purple bacteria chromatophores]. PMID- 4332219 TI - Selective vulnerability to ischaemia: studies in quantitative enzyme cytochemistry of single neurons and neuropil. PMID- 4332220 TI - The polyneuropathy of chronic renal failure. PMID- 4332221 TI - The monooxygenase system in the human fetal liver: subcellular distribution and studies on in vitro metabolism of aniline. PMID- 4332222 TI - The congenital triangular deformity of the tubular bones of hand and foot. PMID- 4332223 TI - Genu valgum: treatment by osteotomy. PMID- 4332224 TI - [Radiologic aspects of central neurogenic jaw tumors]. PMID- 4332225 TI - [Tumors of the salivary glands in East Germany from 1955 to 1959. 2]. PMID- 4332226 TI - [Physiology of protein hormones]. PMID- 4332227 TI - Types of metabolic adaptation in the brain. PMID- 4332228 TI - The development of the cellular slime mould Dictyostelium discoideum: a model system for the study of cellular differentiation. PMID- 4332229 TI - Free radical analogs of histidine. PMID- 4332230 TI - Angiotensin II analogs. 8. The use of free radical containing peptides to indicate the conformation of the carboxyl terminal region of angiotensin II. PMID- 4332231 TI - Angiotensin II analogs. IX. Conformational studies of angiotensin II by proton magnetic resonance. PMID- 4332232 TI - Studies on the structure and formation of polyoma DNA replicative intermediates. PMID- 4332233 TI - Infection of primary African green monkey cells with SV40 monomeric and dimeric DNA. PMID- 4332235 TI - Fine structure of the mastigont system in Tritrichomonas muris (Grassi). PMID- 4332234 TI - The ultrastructure of Encephalitozoon cuniculi (Microsporida, Nosematidae) and its taxonomic significance. PMID- 4332237 TI - The fine structure of the cyst wall of the ciliated protozoon Didinium nastum. PMID- 4332238 TI - [Sporogenesis in the coccidian Aggregata eberthi. Electron microscope study]. PMID- 4332239 TI - The fine structure of differentiating merozoites of Haemoproteus columbae Kruse. PMID- 4332240 TI - [Features of cholangocellular cancer of the liver]. PMID- 4332241 TI - Masticator electromyography in trigeminal neuralgia. PMID- 4332242 TI - The 3'-terminal nucleosides of the high molecular weight RNA of C-type viruses. AB - Tumor virus RNAs from several mammalian and one reptilian species were purified; their 3'-terminal nucleoside was identified by separation of the trialcohols produced by periodate oxidation followed by reduction and tritiation with NaB(3)H(4). Each virus contained uridine as the predominant terminal nucleoside. Molecular weight estimations based on the tritiation reactions were consistent with a structure consisting of four subunits. PMID- 4332243 TI - Autoinhibition of acetylcholine binding to Torpedo electroplax; a possible molecular mechanism for desensitization. AB - Binding of [(3)H]acetylcholine (measured by equilibrium dialysis) to a particulate preparation of Torpedo electroplax exhibits autoinhibition at concentrations higher than 1 muM. It is suggested that autoinhibition results from acetylcholine binding to regulatory sites on its receptor macromolecules. This binding causes the change to a new and inactive conformation and rejection of acetylcholine bound to the larger number of active sites. The relationship to the physiological phenomenon of desensitization is discussed. PMID- 4332244 TI - Electron spin resonance of an irradiated single crystal of 5-chlorouridine. AB - Electron spin resonance signals from radicals of different types have been observed in gamma-irradiated 5-chlorouridine. The strongest absorption, a broad resonance with g values ranging from 2.2 to 3.0, must arise from spin density concentrated on chlorine, probably from trapped atoms. However, hyperfine structure expected from Cl nuclei could not be resolved, evidently because of the low symmetry and diversity of the trapping sites and the large anisotropy in the nuclear coupling and g tensor. A very much weaker resonance, which in the single crystal has a resolvable hyperfine structure, was found to be similar to that observed in normal uridine subjected to thermal H atoms. It is concluded that an H atom, probably released by irradiation from the ribose group, replaces the Cl atom on the basic ring to form normal uridine, and that a second H atom later adds to the uridine to form the observed H-addition radical. The differences in the electron spin resonance constants of this radical from those of uridine bombarded with H can be attributed to the proximity of the trapped Cl atoms and to differences in the crystal structure of the chlorouridine from that of normal uridine. PMID- 4332245 TI - Folding of staphylococcal nuclease: magnetic resonance and fluorescence studies of individual residues. AB - The reversible unfolding and folding of staphylococcal nuclease in the acid transition has been studied by 220 MHz proton magnetic resonance spectroscopy. The values of area, line-width, and chemical shift of each of the imidazole C2 proton resonances of the four histidine residues have been measured in this transition. The change of areas of three histidine resonances and the change of fluorescence of the single tryptophan residue, as a function of pH, appear to follow a single equilibrium. In contrast, a fourth histidine resonance follows a biphasic transition. These findings indicate that local conformational changes can be detected by magnetic resonance spectroscopy in the cooperative transition of the overall structure. PMID- 4332246 TI - Conditions leading to enhanced response to glucagon, epinephrine, or prostaglandins by adenylate cyclase of normal and malignant cultured cells. AB - HeLa S3 cells, a clonal strain adapted for growth in suspension culture, contain adenylate cyclase activity that is stimulated by glucagon, prostaglandin E(1), and epinephrine. Total enzymatic activity and response to hormones is increased as a result of these cells being in stationary culture for several days. The parental strain of HeLa cells normally grown in stationary culture shows even greater adenylate cyclase activity. Hepatoma (HTC) cells grown in suspension culture have no detectable adenylate cyclase activity, but when grown in stationary culture they contain low, but detectable, amounts of adenylate cyclase, which is stimulated by glucagon, epinephrine, or prostaglandins. Chang's liver cells, both suspension and stationary culture, contain relatively high levels of adenylate cyclase that is stimulated by epinephrine or prostaglandin E(1), with differences in activity depending upon culture conditions. Adenylate cyclase of 3T3 and L929 mouse fibroblasts respond to catecholamines, as well as to prostaglandin E(1), but not to glucagon. Characteristic increases in basal activity of adenylate cyclase and in activity in the presence of hormone occurred as cell density increased during stationary culture of certain cell lines, but do not occur with fluoride ion present. In addition to the influence of growth conditions and rate or phase of cell growth on cyclase activity and hormonal response, the cultured cell lines frequently showed marked differences in activity from one another; malignant cells generally exhibited less activity. It is postulated that adenylate cyclase activity may be enhanced by cell to surface contact or cell to cell interaction and that this phenomenon may represent a form of self regulation or modulation of hormonal response by a tissue. PMID- 4332247 TI - Regulation by calcium of in vivo synthesis of 1,25-dihydroxycholecalciferol and 21,25-dihydroxycholecalciferol. AB - Tritiated 1,25-dihydroxycholecalciferol accumulates in several tissues, to an extent that varies with dietary calcium content, 12 hr after the administration of 325 pmoles of tritiated 25-hydroxycholecalciferol to rats. As the dietary and serum calcium concentrations increase, the amount of 1,25 dihydroxycholecalciferol is diminished and the concentration of 21,25 dihydroxycholecalciferol increases. This correlation is especially evident in rats given vitamin D(3). In vitamin D-deficient rats, the repression of 1,25 dihydroxycholecalciferol formation occurs with a diet containing 3% calcium and 20% lactose. The results suggest that the production of 1,25 dihydroxycholecalciferol, believed to be the metabolically active form of vitamin D in the intestine, is responsible for the adaptation of calcium absorption to low dietary concentrations of calcium. PMID- 4332248 TI - Distinguishing reverse transcriptase of an RNA tumor virus from other known DNA polymerases. AB - Assays are described that permit one to distinguish the reverse transcriptase of RNA tumor viruses from known normal cellular DNA-instructed DNA polymerases. Template responses of purified reverse transcriptase were compared with those of similar preparations of the DNA polymerase I of Escherichia coli and of calf thymus polymerase. All three enzymes responded well to the synthetic duplexes poly(dT).poly(A), poly(U).poly(A), and poly(dT).poly(dA). Hence, these duplexes can detect, but cannot distinguish reverse, transcriptase from the known normal DNA polymerases. However, certain oligomer-homopolymer complexes serve as excellent distinguishing agents. The reverse transcriptase responds very well to (dT)(10).poly(A) and very poorly to (dT)(10).poly(dA), whereas both cellular DNA polymerases do not exhibit this behavior.Purified single-stranded RNA also serves as a diagnostic device, since only reverse transcriptase gives a detectable response. To be definitive, a positive response to RNA must be accompanied by a demonstration via molecular hybridization that the DNA product is complementary to the RNA and not to some minor DNA contaminant. PMID- 4332249 TI - Production of altered cell foci by 3-methylcholanthrene in mouse cells infected with AKR leukemia virus. AB - This report describes altered cell foci observed 9-14 days after treatment with 3 methylcholanthrene of mouse-embryo tissue cultures that had previously been infected with wild-type AKR (RNA tumor) virus. The foci consisted of randomly oriented, piled-up, spindle-shaped cells. When heavily stained with Giemsa, the colonies of transformed cells were grossly visible and countable. Under the same experimental conditions, such changes of morphology were not detectable in the uninfected cells treated with 3-methylcholanthrene or in untreated cells infected with virus. The procedure may provide a rapid, quantitative test system for measurement of the oncogenic potential of certain carcinogens. As in similar previous studies in rat and hamster cells, the results suggest that the infectious, but nontransforming, RNA tumor viruses provided nascent oncogenic information, which when activated by 3-methylcholanthrene served as the specific genetic determinants of transformation. PMID- 4332250 TI - Transcription of the polyoma virus genome: synthesis and cleavage of giant late polyoma-specific RNA. AB - The size of virus-specific RNA synthesized in cultured mouse kidney cells infected with polyoma virus was estimated by electrophoresis and sedimentation analysis of RNA extracts from whole cells. Newly synthesized "late" polyoma specific RNA appears as "giant" molecules of heterogeneous size, up to several times larger than a strand of polyoma DNA (1.5 x 10(6) daltons). Treatment with dimethylsulfoxide or urea showed that the large size of these molecules is not due to aggregation. Giant polyoma-specific RNA is strikingly similar in size distribution to "nuclear messenger-like" RNA ("heterogeneous nuclear" RNA) of the host cell. Subsequent to its synthesis, some of the giant polyoma-specific RNA appears to be cleaved to at least three smaller species. PMID- 4332251 TI - Adenosine 3':5'-cyclic monophosphate concentration in the bacterial host regulates the viral decision between lysogeny and lysis. AB - Mutants of Salmonella typhimurium defective in adenylate cyclase (cya gene) or in cAMP receptor protein (crp gene) are lysogenized at reduced frequency by phage P22. One class of the bacterial mutants with an altered RNA polymerase (rif gene) is also lysogenized at reduced frequency. In the three types of mutant bacteria, the phage's decision between lysogeny and lysis is shifted to lysis and the phage form clear plaques. We propose that in wild-type bacteria the cAMP-receptor protein, in combination with cAMP, activates bacterial RNA polymerase to transcribe certain phage genes that are required for efficient lysogenization. Under conditions of strong catabolite repression, when the supply of energy and biosynthetic components is abundant and the concentration of cAMP is low, the phage would multiply and lyse the cell. When the supply of energy is deficient and the concentration of cAMP is high, the phage would lysogenize the cell. Phage mutants have been isolated that form turbid plaques on the three classes of bacterial mutants due to a higher frequency of lysogeny. These phage mutants have been shown by complementation to be defective in the same gene, which we have called the cly gene. These cly mutants lysogenize the wild-type bacteria with a 99% frequency and, thus, do not form plaques on them. Other kinds of bacterial mutants are also lysogenized at reduced frequency by phage P22. They may be altered in other physiological control systems that influence the frequency of lysogenization. PMID- 4332252 TI - Nucleoside diphosphokinase activity associated with DNA polymerases. AB - Nucleoside diphosphokinase activity is present in highly purified preparations of DNA polymerase from Micrococcus luteus and Escherichia coli, and in a partially purified DNA polymerase from avian myeloblastosis virus. The activity is also observed in the protein fragment of molecular weight 76,000 that is produced by subtilisin cleavage of DNA polymerase I from E. coli. The NDP kinase activity in DNA polymerase preparations from M. luteus uses various ribo- and deoxyribonucleoside di- and triphosphates as substrates. The presence of this activity in preparations of DNA polymerase results in the apparent use of deoxyribonucleoside diphosphates as substrates for DNA synthesis, provided that some triphosphate is present to serve as a phosphate donor. PMID- 4332253 TI - Protein synthesis directed by encephalomyocarditis virus RNA: properties of a transfer RNA-dependent system. AB - Small amounts of encephalomyocarditis virus RNA direct a 50-fold increase in amino acid incorporation, in appropriately supplemented ascites tumor cell extracts, under conditions that give rise to authentic viral polypeptides. Incorporation in these crude extracts has a novel characteristic, namely, that it is almost entirely dependent upon the addition of exogenous tRNA. Further, this incorporation is restricted in that tRNA derived from ascites tumor cells or from rat liver permits translation of viral RNA, whereas tRNA from yeast or Escherichia coli does not. These translational barriers are due, at least in part, to an incompatibility between the tRNA of yeast and E. coli and the aminoacyl-tRNA synthetases of the ascites tumor cell. A more extensive basis for this incompatibility is suggested, however, by the failure of the E. coli aminoacyl-tRNA synthetases to restore viral RNA-directed protein synthesis in the presence of tRNA from E. coli, although the coli synthetases fully restore the poly(U)-directed synthesis of polyphenyl-alanine. The possible role that unique or favored codon classes might play in this restriction is considered, together with the implications of the observed requirement for tRNA. PMID- 4332255 TI - The need for a comprehensive psychiatric rehabilitation organization. PMID- 4332254 TI - [Primary liver carcinoma and hemoperitoneum. Report of 2 cases]. PMID- 4332257 TI - [Hyperinsulinism and epilepsy]. PMID- 4332256 TI - [Nuclear amitosis and lobulation in Yoshida's ascitic hepatoma]. PMID- 4332258 TI - [The Nobel Prize in Medicine to Earl W. Sutherland Jr]. PMID- 4332259 TI - The effects of various drugs and toxic agents on bile flow rate and composition in the rat. PMID- 4332260 TI - The effect of various hormones on the uptake and distribution of an organic mercurial compound in the guinea pig eye. PMID- 4332261 TI - Summary of recent abstracts. II. Amoebiasis and intestinal protozoal infections. PMID- 4332262 TI - [Changes in kidney function values under angiotensin effect in various kidney diseases]. PMID- 4332263 TI - [Rare complication after middle face fracture]. PMID- 4332264 TI - [A study of the effect of thyrotropin secretion in human]. PMID- 4332266 TI - Failure of human rheumatoid synovial collagenase to degrade either normal or rheumatoid arthritic polymeric collagen. PMID- 4332265 TI - An improved enzymic hydrolysis of collagen. PMID- 4332267 TI - [Further observations on the antigen composition of cell lines B, F and G transformed by polyoma virus in vivo (from fibro-sarcomatous tumor)]. PMID- 4332268 TI - [Immunological studies with tumors induced with polyoma virus in hamsters]. PMID- 4332269 TI - [Influence of congelation at--196 degrees C on the encystment of Entamoeba histolytica in culture]. PMID- 4332270 TI - Some electrophysiological factors in volley-pitch perception by electrical stimulation. In: Sensorineural hearing loss. PMID- 4332271 TI - On receptors in the postsynaptic membrane of the motor endplate. In: Molecular properties of drug receptors. PMID- 4332272 TI - Neurolysis in elderly patients. PMID- 4332273 TI - Experimental intervertebral discolysis. A critique of collagenase and chymopapain applications. PMID- 4332274 TI - Spontaneous paralysis of the posterior interosseous nerve. A case report and review of the literature. PMID- 4332275 TI - Mitochondrial involvement in cold acclimation. PMID- 4332276 TI - Collagenolytic activity of snake venom: the absence of collagenolytic activity in the trypsin-like enzyme from Crotalus atrox venom. PMID- 4332277 TI - Incorporation of 14 C-labelled non-lipid precursors into lipid of Plasmodium knowlesi in vitro. PMID- 4332278 TI - Insulinomas: evaluation and treatment. PMID- 4332279 TI - Stimulation of glycogenolysis by purified cholera exotoxin in disrupted cells. PMID- 4332280 TI - "Are we blowin' in the wind"? PMID- 4332281 TI - [Hypoadrenalism]. PMID- 4332282 TI - [Radioimmunoassay determination of human plasma ACTH in adrenal and pituitary gland disorders]. PMID- 4332283 TI - [Urinary excretion of endogenous and exogenous ACTH]. PMID- 4332284 TI - [Determination of blood corticoid level by the radiocompetition method in functional tests of the adrenal cortex]. PMID- 4332285 TI - Central and peripheral control of gill movements in Aplysia. AB - Two types of gill contraction in Aplysia were used to study the relation of peripheral and central pathways in controlling behavioral responses in a mollusk. A weak or moderate tactile stimulus to the mantle elicits gill contraction (gill withdrawal reflex) as a component of a more extensive withdrawal response; a stimulus applied directly to the gill elicits a localized response of the gill pinnule (pinnule response). Central pathways through the abdominal ganglion are both necessary and sufficient for the gill-withdrawal reflex, and motor neuron L7 makes direct connections with gill muscles, without engaging the peripheral plexus. Peripheral pathways are necessary and sufficient for the pinnule response. As a result of the independence of peripheral and central pathways, habituation by repeated tactile stimulation of one pathway does not affect the responsiveness of the other pathway. PMID- 4332286 TI - Cyclic adenosine monophosphate and norepinephrine: effect on purkinje cells in rat cerebellar cortex. PMID- 4332287 TI - Rat serum corticosterone assay: use of a radiosteroid assay method. PMID- 4332288 TI - Perchloric acid extraction of adrenocorticosteroids from tissues. PMID- 4332289 TI - [Nonchromaffin paraganglioma of the orbit]. PMID- 4332290 TI - [Recurrent and metastasing skin tumor of mixed salivary gland tumor type]. PMID- 4332291 TI - Sodium and water excretion in dogs with renovascular hypertension. PMID- 4332293 TI - Enzymatic and immunologic alterations in mice infected with lactic dehydrogenase virus. PMID- 4332292 TI - Research complications due to Haemobartonella and Eperythrozoon infections in experimental animals. PMID- 4332294 TI - Ultrastructural studies on elastic fibers using enzymatic digestion of thin sections. PMID- 4332295 TI - [Synthesis of 6-(aminomethylphenoxyacetylamino)-penicillanic acids]. PMID- 4332296 TI - [Gattermann's aldehyde synthesis without hydrocyanic acid in the hydrocarbon series]. PMID- 4332297 TI - Aggregation in dilute solutions of Mn 2+ and inorganic pyrophosphate and its biochemical consequences. PMID- 4332298 TI - The effect of cyclic AMP on glycogenolysis and glycolysis in human platelets. PMID- 4332299 TI - Dissociation of thyrotropin-stimulated hormone secretion and glucose oxidation in thyroid glands by lithium and colchicine. PMID- 4332300 TI - Activities of sialic acid-synthesizing enzymes in rat liver and rat and mouse tumors. PMID- 4332301 TI - Adenosine 3',5'-monophosphate and guanosine 3',5'-monophosphate: a simultaneous protein binding assay. PMID- 4332302 TI - Pathways of intracellular hydrogen transport in the Walker carcinosarcoma 256. II. Observations on oxidoreduction changes of electron carriers in slices. PMID- 4332303 TI - A high molecular weight form of NADH-cytochrome b 5 reductase from ox liver microsomes. PMID- 4332304 TI - Magnetic susceptibility of succinate dehydrogenase: the 4-iron preparation. PMID- 4332305 TI - The redox environment and microbial physiology. I. The transition from anaerobiosis to aerobiosis in continuous cultures of facultative anaerobes. PMID- 4332306 TI - On the structure of the iron-sulfur complex in the two-iron ferredoxins. PMID- 4332307 TI - The effects of lipase on spinach and Chlamydomonas chloroplasts. PMID- 4332308 TI - Cytochrome b 561 of the bovine adrenal chromaffin granules. A high potential b type cytochrome. PMID- 4332309 TI - Effect of isotopic substitution on the electron spin resonance spectra of flavin and flavoprotein free radicals. PMID- 4332310 TI - Induction of aldehyde dehydrogenase in a mitochondrial fraction. PMID- 4332311 TI - A new human cell line (FaDu) from a hypopharyngeal carcinoma. PMID- 4332312 TI - Ultrastructure and observations on the histogenesis of mesotheliomas, "adenomatoid tumors", of the female genital tract. PMID- 4332313 TI - Histologic criteria of serosal rupture and prognosis in gastric carcinoma. PMID- 4332314 TI - Histogenesis of alveolar soft part sarcoma. PMID- 4332315 TI - Ultrastructure of acinic cell carcinoma of the parotid salivary gland. PMID- 4332316 TI - Infiltration of mammary carcinoma as an indicator of axillary node metastasis. A preliminary report. PMID- 4332317 TI - Usefulness of lymphography in childhood neoplasia. PMID- 4332318 TI - Post-biopsy breast carcinoma: a natural experiment in cancer immunology. PMID- 4332319 TI - Carcinoma of the lung: an evaluation of the scalene node biopsy in relation to radiation therapy of the supraclavicular region. PMID- 4332320 TI - Bronchiolo-alveolar carcinoma. A reappraisal after 24 years. PMID- 4332321 TI - The electroencephalogram sleep patterns of middle-aged males. PMID- 4332322 TI - Congenital epulis of the newborn: centennial review of the literature and a report of case. PMID- 4332324 TI - Excitation by ethanol of rat muscle spindles. PMID- 4332323 TI - The effect of 4,4'-biphenylenebis-((2-oxoethylene)-bis-(2,2 diethoxyethyl))dimethylammonium dibromide (DMAE) on the responses of tissues innervated by short adrenergic neurons to catecholamines and ionic stimulants. PMID- 4332325 TI - Interactions of tricyclic antidepressants and 5-hydroxyindolealkylamine precursors on spinal monosynaptic reflex transmission. PMID- 4332326 TI - Potentiation of the inotropic effects of glucagon by theophylline. PMID- 4332327 TI - Phosphatases in testes and epididymides of albino rats after partial body irradiation. PMID- 4332328 TI - [Gastrointestinal complications in burns]. PMID- 4332329 TI - Effect of angiotensin on uptake of 3 H-norepinephrine in dog cutaneous arteries. PMID- 4332330 TI - Avian leukosis antibody response in individuals given chicken embryo derived vaccines. PMID- 4332331 TI - An established R3 mouse mammary tumor cell line; kinetics of mammary tumor virus (MTV) production. PMID- 4332332 TI - -Oxoglutarate carboxylation in liver mitochondria from normal, alloxan diabetic and streptozotocin diabetic rats. PMID- 4332333 TI - Prednisolone in hepatitis by MHV-3 virus: study of the dynamics of virus multiplication in relation to time of prednisolone injection. PMID- 4332334 TI - Effect of mycoplasmas on virus replication and plaque formation in mouse cells. PMID- 4332335 TI - Cysteine interference with chlorambucil-induced teratogenesis in the rat. PMID- 4332336 TI - Increased accuracy of binocular depth perception following REM sleep periods. PMID- 4332337 TI - Possible mechanisms in the pathogenesis of "postinfectious" encephalomyelitis. PMID- 4332338 TI - Respiratory oscillations in chemoreceptor discharge in the control of breathing. PMID- 4332339 TI - [Respiratory enzymes in a psychrophilid and a mesophilic strain of Arthrobacter]. PMID- 4332340 TI - Visual and auditory inputs into the cuneate nucleus. AB - Sound clicks or light flashes modify somatic sensory activity in the cuneate nucleus of the cat. The techniques of gross potential recording in the cuneate nucleus or medial lemniscal tract, of single unit recording in the cuneate nucleus, and of excitability testing of cuneate terminals demonstrate this heterosensory interactionsensory interaction. PMID- 4332341 TI - [Infectious pathology in a general medicine unit]. PMID- 4332342 TI - [Hyperthyroidism in general medicine]. PMID- 4332343 TI - [4 cases of biliodigestive fistula]. PMID- 4332344 TI - [Transparietal punch biopsy of the liver with a Menghini's needle in a general medicine unit. Analysis of a series of 464 consecutive examinations]. PMID- 4332345 TI - [Place of viral diseases among the aggravation factors of chronic bronchitis]. PMID- 4332346 TI - [Increase of cell resistence to the action of viruses and toxins under the influence of protein hydrolysates or mold filtrates]. PMID- 4332347 TI - The presence of microvilli and other membrane fragments in the non-fat phase of bovine milk. PMID- 4332348 TI - The nuclear pores of early meiotic prophase nuclei of plants. PMID- 4332349 TI - A study of the ultrastructure of the small iris vessels in the vervet monkey (Ceropithecus aethiops). PMID- 4332350 TI - [Comparative ultrastructural and morphometrical study of liver parenchyma cells in wistar rats (Rattus norvegicus) and desert rats (Meriones crassus)]. PMID- 4332351 TI - [Electron-microscopic investigations on the subfornical organ of the mouse]. PMID- 4332352 TI - Immunological aspects of Burkitt's lymphoma. PMID- 4332353 TI - Virus infections of bonnet monkeys. PMID- 4332354 TI - The nature of the immune state produced by inactivated vaccinia virus in rabbits. PMID- 4332355 TI - Malignant trophoblastic disorders. Epidemiologic aspects and relationship to hydatidiform mole. PMID- 4332356 TI - Cylindroma of the uuterine cervix with peritoneal metastases: report of a case and review of the literature. PMID- 4332357 TI - Partial placenta accreta in pregnancies following chemotherapy for gestational trophoblastic neoplasms. PMID- 4332358 TI - Aldehyde-oxidizing capacity during development in human and rat liver. PMID- 4332359 TI - Experimental silicosis of the rat. Correlation of functional, biochemical, and histological changes. PMID- 4332360 TI - [Study with fluorescent concanavalin of carbohydrate sites of membranes in human fetal cells; relationship with cell differentiation]. PMID- 4332361 TI - [Parasporal inclusion of Bacillus thuringiensis var. Berliner 1715: moment and site of its initiation; relationship to sporangial DNA]. PMID- 4332362 TI - [Aggregating action of phospholipase C of Clostridium welchii on human platelets]. PMID- 4332363 TI - Injury and repair in arterial tissue in the rabbit. Analysis of DNA, RNA, hydroxyproline, and lactate dehydrogenase in experimental arteriosclerosis. PMID- 4332364 TI - Direct measurement of superficial and deep venous flow in the cat kidney. Effects of epinephrine, angiotensin, microspheres, and renal nerve stimulation. PMID- 4332365 TI - Diagnostic value of urinary enzyme determinations. PMID- 4332366 TI - Serum factors in tumor-free patients cancelling the blocking of cell-mediated tumor immunity. PMID- 4332367 TI - [Comparative evaluation of clinical, radiological and anatomical measurements of mammary tumors]. PMID- 4332368 TI - Demonstration of two distinct components in the early antigen complex of Epstein Barr virus-infected cells. PMID- 4332369 TI - Biochemical mechanisms of drug resistance. XII. Uridine kinases from mouse leukemic cells sensitive and resistant to 5-azacytidine. PMID- 4332370 TI - [Isolation of intracytoplasmic type "A" particles from murine lymphoma induced by ethyl-urethan]. PMID- 4332371 TI - Isolation of a tumor factor responsible for angiogenesis. AB - Human and animal solid tumors elaborate a factor which is mitogenic to capillary endothelial cells. This factor has been called tumor-angiogenesis factor. The important components of TAF are RNA and protein. It is suggested that blockade of this factor (inhibition of angiogenesis) might arrest solid tumors at a tiny diameter of a few millimeters. PMID- 4332372 TI - Angiotensin and renin in rat and dog brain. AB - An enzyme with the characteristics of classical renin was isolated from brain extracts of nephrectomized dogs. This enzyme is thermolabile, nondialyzable, and forms a vasoconstrictive material when incubated with renin plasma substrate at pH 7. A short lasting pressor activity was also found in brain extracts of dogs and rats. This activity was due to a substance identified by chemical and pharmacological tests as angiotensin. Countercurrent distribution of brain extracts of rats showed that 38% of the pressor activity corresponded to angiotensin II and the remainder to angiotensin I. A remarkable correlation was found between angiotensin and norepinphrine concentrations in different portions of the encephalon of the dog. PMID- 4332373 TI - Measurement of plasma angiotensinase activity by a radioimmunoassay method. PMID- 4332374 TI - Fine structure of normal hemocytes in Dermacentor andersoni Stiles (Acari:Ixodidae). PMID- 4332375 TI - Histochemical properties of the excretory organ of Anisakis sp. larva. PMID- 4332376 TI - Characterization of deoxyribonucleic acid of Entamoeba histolytica by cesium chloride density centrifugation. PMID- 4332377 TI - Occurrence of atromentin and thelephoric acid in cultures of Clitocybe subilludens. PMID- 4332378 TI - The action of carbon dioxide on afferent transmission in the dorsal column lemniscal system. AB - 1. Transmission in the lemniscal afferent pathway was studied in thirteen decerebrate, unanaesthetized cats while changing the concentration of inspired P(CO2).2. 2-20% CO(2), when inhaled for 0.2. PMID- 4332381 TI - [Neurologic syndrome associating a multiple sclerosis, spinal cord atrophy and radicular compression]. PMID- 4332383 TI - [Classification of remote outcomes of Botkin's disease]. PMID- 4332382 TI - [The renin-angiotensin-aldosterone system in arterial hypertension]. PMID- 4332384 TI - [2 cases of double glioblastoma]. PMID- 4332386 TI - The histopathology of peripheral neuropathy. PMID- 4332385 TI - [Pathophysiology of neuromuscular transmission disturbances]. PMID- 4332387 TI - Importance of catecholamine release by nerve impulses for free operant behavior. PMID- 4332388 TI - [Use of corticosteroids in febrile states and ileus caused by acute pancreatitis]. PMID- 4332389 TI - Abdominal cutaneous nerve entrapment syndrome. PMID- 4332391 TI - [Characteristics of the adrenergic function of the adrenals and adrenocorticotropic activity of the pituitary gland in patients with eczema and neurodermatitis]. PMID- 4332390 TI - Additional cytochemical and morphological observations on the tegument of Haematoloechus medioplexus. PMID- 4332392 TI - Transfer of foot-and-mouth disease virus in the nose of man from infected to non infected animals. PMID- 4332393 TI - Viral hepatitis in the autopsy specimen. PMID- 4332394 TI - [Electronmicroscopic findings in experimental insulitis after injection of anti insulin serum]. PMID- 4332395 TI - [Ultrastructure of the orthotopic transplanted, allogeneic dog liver]. PMID- 4332396 TI - [Endoscopic biopsy in diagnosis of lung cancer]. PMID- 4332397 TI - [Blastomogenesis in rats with persistent estrus]. PMID- 4332398 TI - [Resistance to Rous tumor cells in mice induced by Rous virus]. PMID- 4332399 TI - [Hypophosphatemic vitamin D resistant rickets]. PMID- 4332400 TI - [Myocardial ultrastructure of a rabbit in the course of poisoning with the toxin of Clostridium perfringens type A]. PMID- 4332401 TI - The effects of methyl-mercury-dicyandiamide on the peripheral nerves and spinal cord of rats. PMID- 4332403 TI - Differential effect of sleep deprivation on the two slow wave sleep stages in the cat. PMID- 4332402 TI - Amino acid incorporation in protein during the "silent phase" before organo mercury and p-bromophenylacetylurea neuropathy in the rat. PMID- 4332404 TI - Facilitation of sympathetic neurotransmission in the cat spleen after inhibition of prostaglandin synthesis. PMID- 4332405 TI - Carbon monoxide production and utilization by higher plants. PMID- 4332406 TI - Carbon monoxide bonding in hemeproteins. PMID- 4332408 TI - Factors influencing the inhibitory effect of carbon monoxide on cytochrome P-450 catalyzed mixed function oxidation reactions. PMID- 4332407 TI - Mitochondrial responses to carbon monoxide toxicity. PMID- 4332409 TI - The burning of CO in tissues. PMID- 4332410 TI - Subsynaptosomal distribution of enzymes involved in the metabolism of lipids. PMID- 4332411 TI - The isolation and characterization of plasma membrane from cultured cells. I. The chemical composition of membrane isolated from uninfected and oncogenic RNA virus converted chick embryo fibroblasts. PMID- 4332412 TI - The isolation and characterization of plasma membranes from cultured cells. II. The chemical composition of membrane isolated from uninfected and oncogenic RNA virus-converted parenchyma-like cells. PMID- 4332413 TI - Arabinose transport in araC- strains of Escherichia B-r. PMID- 4332414 TI - Quantitation of N-acetyl-D-galactosamine-like sites on the surface membrane of normal and transformed mammalian cells. PMID- 4332415 TI - Newly synthesized mammalian cell DNA: studies on the reasons for the increased affinity to nitrocellulose. PMID- 4332416 TI - Binding of ethidium bromide to 5-S ribosomal RNA. PMID- 4332417 TI - Aminoacyl transfer RNA formation. I. Absence of pyrophosphate-ATP exchange in aminoacyl-tRNA formation stimulated by polyamines. PMID- 4332418 TI - Acetylcholine in synaptic transmission. PMID- 4332419 TI - The rate constants of valinomycin-mediated ion transport through thin lipid membranes. AB - Electrical relaxation experiments have been performed with phosphatidylinositol bilayer membranes in the presence of the ion carrier valinomycin. After a sudden change of the voltage a relaxation of the membrane current with a time constant of about 20 musec is observed. Together with previous stationary conductance data, the relaxation amplitude and the relaxation time are used to evaluate the rate constants of valinomycin-mediated potassium transport across the lipid membrane. It is found that the rate constants of translocation of the free carrier S and the carrier-ion complex MS(+) are nearly equal (2.10(4) sec(-1)) and are of the same order as the dissociation rate constant of MS(+) in the membrane-solution interface (5.10(4) sec(-1)). The equilibrium constant of the heterogeneous association reaction M(+) (solution) + S (membrane) --> MS(+) (membrane) is found to be approximately 1 M(-1), about 10(6) times smaller than the association constant in ethanolic solution. PMID- 4332420 TI - [Influence of prostaglandin E 1 on the response of the guinea-pig phrenic nerve isolated diaphragm muscle preparation]. PMID- 4332421 TI - Reticular inhibition of internuncial cells in the rat lateral geniculate body. PMID- 4332422 TI - Pharmacological evidence for GABA as the transmitter in granule cell inhibition in the olfactory bulb. PMID- 4332423 TI - Unitary components in corticopontine activation of the cat. PMID- 4332424 TI - Effect of ACTH on the incorporation of L-(U-14C) leucine into the brain and spinal cord in mice. PMID- 4332425 TI - Basal ganglia-diencephalon synaptic relations in the cat. 3. An intracellular study of ansa lenticularis, lenticular fasciculus and pallidosubthalamic projection activities. PMID- 4332426 TI - [Immunodepressive treatments allowing formation of cartilage and bone induced by xenogenic transplantations]. PMID- 4332427 TI - [Suppression of the pontogeniculo-occipital points of sleep by lesion or injection in situ of 6-hydroxydopamine in the tegmentum of the pons]. PMID- 4332428 TI - [Cardiovascular effects of alloxan]. PMID- 4332429 TI - [Influence of GABA transaminase inhibition on the sleep of rats]. PMID- 4332430 TI - The effects of lights-off stimulation on the circadian distribution of REM sleep in the cat. PMID- 4332431 TI - The nucleoside-copper (II) interaction and the tautomeric forms of the nucleosides. PMID- 4332432 TI - The regulatory role of phosphodiesterase in adenosine cyclic 3',5'-monophosphate mediated ACTH. PMID- 4332433 TI - The effect of dihydroergotamine on the phosphodiesterase activity of cat grey matter. PMID- 4332434 TI - Relation between the glycogen content of the liver and liver weight, and its meaning for enzymology. PMID- 4332437 TI - [Combination of diffuse glomerulonephritis with Wilms' tumor in an adult]. PMID- 4332436 TI - Inactivation studies of angiotensin II by purified enzymes. PMID- 4332435 TI - Further studies on the effects of corticosterone on adrenocortical cells of hypophysectomized ACTH-treated rats. PMID- 4332438 TI - [Present stand in the clinical study of sleep]. PMID- 4332439 TI - [Therapy and prevention of hemolytic disease of the newborn caused by the Rh factor]. PMID- 4332441 TI - [Surgical treatment of the sulcus ulnaris syndrome]. PMID- 4332440 TI - [Developmental aspects of cutaneous epithelioma. Electron microscopic studies]. PMID- 4332442 TI - Cholinergic substrate for drinking in the rat. PMID- 4332443 TI - [Primary cancer of the liver]. PMID- 4332444 TI - [Epidemiology and pathogenesis of listeriosis]. PMID- 4332445 TI - [Clinical forms of listeriosis in adults]. PMID- 4332446 TI - [Problems of listeriosis in gynecology and obstetrics]. PMID- 4332447 TI - [Listeria infections of newborn infants]. PMID- 4332448 TI - [Laboratory diagnosis of listeria infections]. PMID- 4332449 TI - [Anatomopathological study of human listeria infections]. PMID- 4332450 TI - [Animal listeria infections]. PMID- 4332451 TI - Protein-polypeptide hormones of the human placenta. PMID- 4332452 TI - [Diagnostic difficulties in primary liver carcinoma]. PMID- 4332453 TI - [Antibiotics and corticosteroids in the corticosteroids in the treatment of burns]. PMID- 4332454 TI - On a possibility to connect quantitatively ocular hypertension and damage to the optic nerve. PMID- 4332455 TI - Decreased pulmonary oxygen toxicity by pretreatment with hypoxia. PMID- 4332456 TI - Polar and neutral lipids of pig gingiva. PMID- 4332457 TI - Iodide concentration by human labial salivary glands. PMID- 4332458 TI - Possible diagnostic applications of sensory evoked potentials. PMID- 4332459 TI - [Lymphatic capillaries and vessels of the liver in normal rats and in those with experimental cancer]. PMID- 4332460 TI - Conformational changes and aggregation in phosphoribosyladenosine triphosphate synthetase. Ligand effects on hydrogen exchange and hydrophobic probe uptake. PMID- 4332461 TI - On the mechanism of action of fructose 1,6-diphosphatase. Inhibition by structural analogs of fructose 1,6-diphosphate. PMID- 4332462 TI - Structure of schizokinen, an iron-transport compound from Bacillus megaterium. PMID- 4332463 TI - Effects of estradiol on uterine ribonucleic acid metabolism. I. In vitro uptake and incorporation of ribonucleic acid precursors. PMID- 4332464 TI - Infectious mononucleosis and its relationship to EB virus antibody. A joint investigation by university health physicians and P.H.L.S. laboratories. AB - In October 1969 tests made on 1,457 students entering English universities and colleges showed that 57% already possessed antibody to EB virus. The students without antibody in these initial tests were retested seven months later and by then 12% had acquired antibody. In about one-third of them the acquisition of antibody was not associated with any illness. In about 20% respiratory and other illness had occurred, but these symptoms were almost equally frequent in students who had not acquired antibody. Nearly half had developed infectious mononucleosis. In students in whom the acquisition of EB virus antibody was associated with the clinical and haematological manifestations of infectious mononucleosis the Paul-Bunnell test was almost invariably positive. In contrast, when these manifestations were not associated with the acquisition of EB virus antibody the Paul-Bunnell test was always negative.Tests for cytomegalovirus antibody were also made on the students at entry. The proportion of students with this antibody was much less (30%) and only a small proportion (1.4%) of those without antibody had acquired cytomegalovirus antibody seven months later. In the only patient in whom the acquisition of cytomegalovirus antibody alone was associated with the clinical and haematological features of infectious mononucleosis the Paul-Bunnell test was negative. PMID- 4332465 TI - Treatment of Bell's palsy. PMID- 4332466 TI - [Internuclear lesions: effects on eye movements during wakefulness and paradoxical sleep in the cat]. PMID- 4332467 TI - Synaptic actions evoked from the red nucleus on the spinal alpha-motorneurons in the Rhesus monkey. PMID- 4332468 TI - Unit spontaneous activity in the amygdala: relation between the long term stability of the discharge and the EEG. PMID- 4332470 TI - Pattern of incorporation of 32 P into the phospholipids of the rat tapeworm Hymenolepis diminuta. PMID- 4332469 TI - Electron transport and coupled energy generation in Pseudomonas saccharophila. PMID- 4332471 TI - The feedback control of hepatic cholesterol synthesis in Ugandan patients with liver disease. PMID- 4332472 TI - Expression of various tumor-specific antigens in polyoma virus-induced tumors. PMID- 4332473 TI - Protein methylases in hepatomas. PMID- 4332474 TI - Glycogen metabolism in regenerating liver and liver neoplasms. PMID- 4332475 TI - DNA synthesis in Morris hepatoma 9618A and in host liver following partial hepatectomy in rats adapted to controlled feeding schedules. PMID- 4332476 TI - Detection of avian and mammalian oncogenic RNA viruses (oncornaviruses) by immunofluorescence. PMID- 4332477 TI - [A colorimetric method for the measurement of serum glutamate dehydrogenase activity]. PMID- 4332478 TI - Cell proliferation in cancer. PMID- 4332479 TI - [Ultrastructure of Mycoplasma salivarium and of Mycoplasma orale in tissue culture. The problem of the differentation because of the similarities in the cellular surfaces]. PMID- 4332480 TI - Lysosomal enzyme activity in the interstitial fluid of solid mouse tumour transplants. PMID- 4332481 TI - Fine structure of primary rat hepatoma induced by 2-acetylaminofluorene feeding. PMID- 4332482 TI - Transport of streptococci in throat swabs on Loeffler's serum slants. PMID- 4332483 TI - Persistence of omite residues on and in Navel oranges and lemons and in laboratory-processed citrus pulp cattle feed. PMID- 4332484 TI - Inhibitory effect of oligomycin on replication of sendai virus and a bovine enterovirus in cultured cells. PMID- 4332486 TI - [Cauda equina syndrome due to nervous amylosis in Waldenstrom's macroglobulinemia]. PMID- 4332485 TI - Inositol requirement of mammalian cells in tissue culture. PMID- 4332487 TI - Multiple cranial nerve involvement with herpes zoster. PMID- 4332488 TI - [An epidemic focus of viral hepatitis, probably due to virus B, in a community of pre-school children (epidemiological and clinical aspects)]. PMID- 4332489 TI - [Ilioinguinal syndrome]. PMID- 4332490 TI - [Effects of Bordetella pertussis injection in newborn mice]. PMID- 4332491 TI - [Some histochemical reactions in the walls of the aorta in rats chronically poisoned by inhalation of carbon disulfide]. PMID- 4332493 TI - Modern views on pharmacology. XI. Transmitter substances in the central nervous system. PMID- 4332492 TI - The present status of haemodialysis. PMID- 4332494 TI - On the origin of Foa-Kurloff cells. PMID- 4332495 TI - Effects of partial hepatectomy in rats on two transplantable hepatomas. Changes in weight and in synthesis of DNA and ferritin. AB - Partial hepatectomy in rats carrying Reuber H-139 and H-35 hepatomas is followed by rapid growth of these tumors. At comparable times after implantation, average wet weights of H-139 or H-35 hepatomas in partially hepatectomized rats were significantly higher than average wet weights of these tumors in control rats. In H-35 hepatomas growing subcutaneously, synthesis of DNA, as shown by incorporation of tritiated thymidine, was depressed 18 hours after a two-thirds hepatectomy in the host. Between 18 and 36 hours after partial hepatectomy, DNA synthesis rose steadily, with a maximum at about 36 hours. Incorporation of (14)C leucine into ferritin (apoferritin) reached a maximum in liver and, to less extent, also in subcutaneous H-35 hepatomas, 48 hours after partial hepatectomy and returned to normal levels at 72 hours. The increase in wet weight of the tumors is most likely the result of an increase in rate of growth concomitant with the restoration of liver mass. The rise in synthesis of DNA and of ferritin in hepatoma cells after partial hepatectomy suggests that these hepatomas were affected by the same humoral factor or mechanism that stimulates cell division and protein synthesis in the liver immediately after partial hepatectomy. PMID- 4332496 TI - Viruses and the connective tissue diseases. PMID- 4332497 TI - Syndrome of incipient prechiasmal optic nerve compression. Progress toward early diagnosis and surgical management. PMID- 4332498 TI - A method for isolating aortic mitochondria exhibiting high respiratory control. PMID- 4332499 TI - Procedures for the isolation of two distinct lipopigments from human brain: lipofuscin and ceroid. PMID- 4332500 TI - The fine structure of the sympathetic axons within the Pacinian corpuscle. PMID- 4332501 TI - The fine structure of thin unmyelinated axons within muscle spindles. PMID- 4332503 TI - Chemical identification of acetylcholine in squid-head ganglion. PMID- 4332502 TI - Supraspinal influences on hindlimb reflex pathways during natural sleep in the kitten. PMID- 4332504 TI - Filamentous intranuclear bodies and associated multilaminate figures. PMID- 4332505 TI - Renin activity in brain tissue of puppies and adult dogs. PMID- 4332506 TI - [Varioliform psutulosis of Kaposi and Juliusberg of herpetic origin, superinfected with a bullous genodermatosis in a 21-year-old girl: Hailey-Hailey disease, transitional form with Darier's disease. Familial study and discussion]. PMID- 4332507 TI - Interaction of a carcinogen, 4-nitroquinoline-1-oxide, with nucleic acids: chemical degradation of the adducts. PMID- 4332508 TI - Desiccant-induced ultrafiltration across an artificial membrane. PMID- 4332509 TI - Study of an attenuated strain of feline infectious enteritis (panleucopaenia) virus. I. Spread of vaccine virus from cats affected with feline respiratory disease. AB - In the course of developing a living attenuated feline infectious enteritis (panleucopaenia) vaccine, it was found that respiratory disease-infected cats newly inoculated with this vaccine spread vaccine virus to respiratory disease infected in-contact controls. These in-contact controls were able to infect other cats with which they were placed in contact so that after five natural transmissions in this way and two oral administrations and subsequent re isolations, reversion to virulence became evident. It is clear that before general release of a new living feline infectious enteritis vaccine, there must be satisfactory evidence that concurrent infection will not affect the safety of the modified antigen.In cats infected with feline infectious enteritis there appears to be a short period, coinciding with the onset of leucopaenia, during which they are highly infectious. It seems possible that some infected animals may become immune carriers because virus has been recovered from the small intestine of two of four cats with significant antibody titres 22-24 days after exposure to infection. PMID- 4332510 TI - Study of an attenuated strain of feline infectious enteritis (panleucopaenia) virus. II. Removal of the spread factor by further passaging in tissue culture. AB - The propensity of an attenuated strain of feline infectious enteritis (panleucopaenia) virus to spread from vaccinated cats affected with intercurrent feline respiratory disease to unvaccinated in-contact cats was eradicated by further passaging of the vaccine virus in tissue culture. No virus was recovered from, and no antibody was found in the sentinel cats in contact with seven vaccinated animals. Thus, a further 27 passages of the vaccine virus in tissue culture has eliminated the spread factor. PMID- 4332512 TI - Endoneurial deposits of amyloid-like fibrils in a recurrent demyelinating neuropathy. An electron microscope study. PMID- 4332511 TI - Cytomegalovirus antibody production in renal transplant patients. AB - Sera were examined from 50 patients on the renal transplant unit, Cambridge, for antibody against cytomegalovirus by complement fixation and by immunofluorescence for IgG and IgM antibodies.The incidence of antibody on admission was 84% with a possible further 8% so that nearly all had been infected at some time by CMV.43 (86%) patients showed evidence of active infection after admission, 39 by serology and four only from the examination of post-mortem material.Twenty-one patients produced IgM antibody and production was prolonged for years in patients that survived. Antibody production was related both to transplantation and admission to hospital.The evidence indicated that primary CMV infections were rare, that IgM antibody production was the result of active infection and that this could be attributed to reactivation without the need to invoke re-infection as the source although this type of patient is both susceptible and exposed to re infection. PMID- 4332513 TI - s-Collidine as a buffering system for glutaraldehyde perfusion of the central nervous system. PMID- 4332514 TI - Radicals formed by electron attachment to peptides. PMID- 4332515 TI - An electron spin resonance study of the photoionization of thymine. The thymine cation and anion radicals. PMID- 4332516 TI - Electron spin resonance study of radicals produced in irradiated aqueous solutions of amines and amino acids. PMID- 4332517 TI - Avian pox in an immature red-tailed hawk. PMID- 4332518 TI - Evaluation of an in vitro technique for quantitative assay of adrenocortical secretion in the California ground squirrel. PMID- 4332519 TI - Adrenal gland size as an index of adrenocortical secretion rate in the California ground squirrel. PMID- 4332520 TI - Some factors contributing to the development of fungus infection in freshwater fish. PMID- 4332521 TI - The harp seal, Pagophilus groenlandicus, (Erxleben, 1777): XVI Epiphyseal fusion. PMID- 4332522 TI - Enterotoxemia of wildfowl due to Cl. perfringens type C. PMID- 4332523 TI - [Gas-chromatography]. PMID- 4332524 TI - A comparison of lobeline and nicotine at the frog neuromuscular junction. PMID- 4332525 TI - Cerebral effects of acute ammonia intoxication. II. The effect upon energy metabolism. PMID- 4332528 TI - Demonstration of specific antigen(s) on the surface of SV40--transformed cells using the mixed hemagglutination technique. PMID- 4332526 TI - Pathogenesis and treatment of thyrotoxicosis. PMID- 4332527 TI - Antilymphocytic serum and polyoma oncogenesis in rats. PMID- 4332529 TI - Current problems of tissue banking. PMID- 4332530 TI - Orthotopic liver transplantation in man. PMID- 4332531 TI - Renal transplants in children. PMID- 4332532 TI - Studies of anti-lymphocyte globulins made from thoracic duct lymphocytes. PMID- 4332533 TI - Specific suppression of cell-mediated immune responses. PMID- 4332534 TI - Studies on the FMR antigen. PMID- 4332535 TI - Cytotoxic antibodies against adeno tumors in rabbit anti-adenovirus immune sera. PMID- 4332536 TI - [Neuroendocrine changes in open penetrating craniocerebral trauma (experimental morphological study)]. PMID- 4332537 TI - [Neurological syndromes in para-influenza]. PMID- 4332539 TI - [Oxidative metabolism of lymphocytes]. PMID- 4332538 TI - [Enzyme activity of the cerebrospinal fluid in pathological processes of the central nervous system]. PMID- 4332540 TI - Growth and malignancy of ovarian tumours in pregnancy. PMID- 4332541 TI - The wall teichoic acids of Lactobacillus plantarum N.I.R.D.C106. Location of the phosphodiester groups and separation of the chains. AB - 1. The identities of the component glycerol glucosides of the wall teichoic acids of Lactobacillus plantarum N.I.R.D. C106 have been confirmed by methylation analysis. These glucosides are alpha-d-glucopyranosyl-(1-->1)-l-glycerol, alpha-d glucopyranosyl-(1-->2)-alpha-d-glucopyranosyl-(1-->1)-l-glycerol and alpha-d glucopyranosyl-(1-->3)-alpha-d-glucopyranosyl-(1-->1)-l-glycerol. 2. These units are connected by phosphodiester groups attached to the 3(l)-hydroxyl group of glycerol and the 6-hydroxyl group of the non-reducing terminal glucose residues in the adjacent unit. 3. Concanavalin A forms a precipitate with the teichoic acid and the material so precipitated contains only the alpha-d-glucopyranosyl-(1 ->2)-alpha-d-glucopyranosyl -(1-->1)-l-glycerol component. This unit is therefore present in a homogeneous polymer so that the teichoic acid is a mixture of this and of other possibly homogeneous chains containing the other two components. PMID- 4332542 TI - Studies on the structure and metabolism of glycogen in some abnormal human infants. AB - 1. The liver and muscle tissues of 14 human anencephalic babies were examined for glycogen content and structure, and for the activities of several glycogen metabolizing enzymes. 2. In both tissues glycogen content increased with gestation age; the muscle glycogens had a slightly but significantly lower degree of branching than the corresponding liver glycogens. 3. All the expected glycogen metabolizing enzymes were present; acid maltase activities were higher and phosphoglucomutase activities were lower than the results reported for human adult tissues. Glucose 6-phosphatase activity increased significantly with gestation age. PMID- 4332545 TI - Decreased activities of enzymes associated with sialic acid synthesis in livers of diabetic rats. PMID- 4332543 TI - Calcium binding by human erythrocyte membranes. AB - 1. The characteristics of Ca(2+) binding to haemoglobin-free human erythrocyte membranes were investigated by using (45)Ca and centrifugation partition of ;ghosts' from their external incubation medium. Equilibrium of ;ghosts' with external Ca(2+) required less than 15min. 2. The binding did not vary with temperature in the range 0-37 degrees C. 3. At pH7.4 ;ghosts' bound a maximum of 283mumol of Ca(2+)/g of ;ghost' protein, equivalent to 6.85x10(7) Ca(2+) ions per cell. 4. Increasing the ionic strength from 0.01 to 0.46 diminished Ca(2+) binding, as did ATP in concentrations ranging from 0 to 15mm in the incubation medium. 5. An increase of the pH from 3.0 to 9.3 caused a marked increase in the amount of Ca(2+) bound. 6. Extraction of (45)Ca-labelled ;ghosts' with chloroform methanol showed that the distribution of Ca(2+) was: 79% protein-bound, 16% lipid bound, 5% in the aqueous phase, presumably non-bound. Most of the lipid-bound Ca(2+) (about 80%) was associated with a phospholipid fraction containing phosphatidylserine, phosphoinositides and phosphatidylethanolamine, giving a molar Ca(2+): phosphorus ratio of about 1:2. PMID- 4332544 TI - Reactions of D-glyceraldehyde 3-phosphate dehydrogenase with chromophoric thiol reagents. AB - The kinetics of the reaction of d-glyceraldehyde 3-phosphate dehydrogenase with 5,5'-dithiobis-(2-nitrobenzoic acid) show that NAD(+) dissociates from the enzyme before the reaction. In contrast 2-chloromercuri-4-nitrophenol reacts with the holoenzyme without prior dissociation of NAD(+). These studies and observations on the dissociation constant of NAD(+) to the lobster enzyme show that NAD(+) must dissociate from sites modified by substrates during the reductive dephosphorylation of 1,3-diphosphoglycerate. All four sites per tetramer of the apoenzyme are acylated by 1,3-diphosphoglycerate. Hydrolysis of the acyl-enzyme occurs at a significant rate even in the absence of NAD(+), which may explain previous estimates that only two sites per tetramer can readily be acylated. PMID- 4332546 TI - The developing scene: ten-year review of a psychiatric hospital population. PMID- 4332547 TI - Poland's syndrome. PMID- 4332548 TI - [Pancreatic lithiasis of bovines and nature of the subsoil of the grazing area]. PMID- 4332549 TI - Chemical structural requirements for induction of oocyte maturation and spawning in starfishes. PMID- 4332550 TI - Directories facilitate use of community resources. PMID- 4332551 TI - The neurological effects of methyl bromide poisoning. PMID- 4332552 TI - Kinetic studies of the lipid requirement of mitochondrial cytochrome c oxidase. PMID- 4332553 TI - The specific binding of three fragments of staphylococcal nuclease. PMID- 4332554 TI - The mechanism of action of the enzyme uridine diphosphoglucose 4-epimerase. Proof of an oxidation-reduction mechanism with direct transfer of hydrogen between substrate and the B-position of the enzyme-bound pyridine nucleotide. PMID- 4332555 TI - Tryptophanyl transfer ribonucleic acid synthetase of Escherichia coli. I. Purification of the enzyme and of tryptrophan transfer ribonucleic acid. PMID- 4332556 TI - L-glycerol 3-phosphate dehydrogenase. I. Effects of the substrates on the catalytic properties of the hepatic nicotinamide adenine dinucleotide-linked enzyme from the rabbit. PMID- 4332557 TI - Xylitol metabolism in perfused rat liver. Interactions with gluconeogenesis and ketogenesis. PMID- 4332558 TI - Control of the removal of reducing equivalents from the cytosol in perfused rat liver. PMID- 4332559 TI - Purification and some properties of cytochrome c oxidase from the yeast Saccharomyces cerevisiae. PMID- 4332561 TI - Studies on modified hemoglobins. 3. Spin states of ferric hemoglobin, semi hemoglobin, and isolated subunit chains. PMID- 4332560 TI - Studies on the active site of clostripain. The specific inactivation by the chloromethyl ketone derived from -N-tosyl-L-lysine. PMID- 4332562 TI - Direction of polymerization by the avian myeloblastosis virus deoxyribonucleic acid polymerase. PMID- 4332563 TI - Hormone-dependent accumulation of rough endoplasmic reticulum in mouse mammary epithelial cells in vitro. PMID- 4332564 TI - Phosphorylation of endogenous protein of rat brain by cyclic adenosine 3',5' monophosphate-dependent protein kinase. PMID- 4332565 TI - Effect of substrate analogues on the kinetics of the reaction catalyzed by adenosine triphosphate: arginine phosphotransferase. PMID- 4332566 TI - High pressure anion exchange chromatographic measurement of cyclic adenosine 3',5'-monophosphate and cyclic (14C) adenosine monophosphate specific activity in myocardium prelabeled with (14C) adenosine. PMID- 4332569 TI - Resistance of vegetative cells of Clostridium welchii to low pH. PMID- 4332567 TI - Regulation of rat liver glucose 6- phosphate dehydrogenase levels by adenosine 3', 5' -monophosphate. PMID- 4332570 TI - Neoplasms of mixed mesenchymal and neuroepithelial type. With consideration of the relationship between meningioma and neurilemmoma. PMID- 4332571 TI - Uptake of radioiodinated human chorionic gonadotropic hormone by ovarian carcinoma. PMID- 4332572 TI - Scintiphotos of the pancreas: analysis of 134 studies. PMID- 4332573 TI - Peripheral neuropathy associated with vitamin-B 12 deficience in captive monkeys. PMID- 4332574 TI - Preliminary observations on the fine structure of the pansporoblast of Thelohania bracteata (Strickland, 1913) (Microsporida, Nosematidae) as revealed by freeze etching electron microscopy. PMID- 4332575 TI - Cardiac catecholamine metabolism in heart failure. PMID- 4332576 TI - Ischemic heart disease and catecholamines. PMID- 4332578 TI - Disappearance rates of exogenous and endogenous ACTH from rat plasma measured by bioassay and radioimmunoassay. PMID- 4332577 TI - Viral diseases of nonhuman primates in the wild. PMID- 4332579 TI - Effect of catecholamines and methylprednisolone on carbohydrate metabolism of dogs. PMID- 4332580 TI - Clinical aspects of uraemic polyneuropathy. PMID- 4332581 TI - Advances in the treatment of sexually transmitted diseases. PMID- 4332582 TI - Antagonists of angiotensin. Substitution of an aliphatic chain to phenyl ring in position 8. PMID- 4332584 TI - [Some principal problems of surgical treatment of gastric stump cancer]. PMID- 4332583 TI - Competitive antagonists of angiotensin II on the isolated rat stomach strip. PMID- 4332585 TI - [Role of adenoviruses in the development of group infections in children]. PMID- 4332587 TI - The eccrine sweat glands of the palms and soles of the common marmoset (Callithrix jacchus). PMID- 4332586 TI - [Study of the mechanism of lac-operon derepression in E. Coli K12 cells under the effect of steroid hormones and ACTH]. PMID- 4332589 TI - Maximal aerobic capacity of 6--15 year-old girls and boys with subnormal intelligence quotients. PMID- 4332588 TI - [Hepatoma in Argentina. Review of 64 cases among 22,170 autopsies]. PMID- 4332590 TI - Bartter's syndrome. A manifestation of renal tubular defects. PMID- 4332591 TI - Isolation and identification of 25-hydroxycholecalciferol from human plasma. PMID- 4332592 TI - Comments on "the interpretation of the EPR and Mossbauer spectra of two-iron, one electron iron-sulfur proteins". PMID- 4332593 TI - Conversion of protein kinase to a cyclic AMP independent form by affinity chromatography on N 6 -caproyl 3',5'-cyclic adenosine monophosphate-sepharose. PMID- 4332594 TI - Attachment of a fluorescent label to 4-thiouracil and 4-thiouridine. PMID- 4332595 TI - Composition and structure of camphor hydroxylase components and homology between putidaredoxin and adrenodoxin. PMID- 4332596 TI - Amino acid sequence of cytotoxin I from the venom of the Indian cobra (Naja naja). PMID- 4332597 TI - Rate-determining processes and the number of simultaneously active sties of D glyceraldehyde 3-phosphate dehydrogenase. AB - Transient kinetic studies of the reversible oxidative phosphorylation of d glyceraldehyde 3-phosphate catalysed by d-glyceraldehyde 3-phosphate dehydrogenase show that all four sites of the tetrameric lobster enzyme are simultaneously active, apparently with equal reactivity. The rate-determining step of the oxidative phosphorylation is NADH release at high pH and phosphorolysis of the acyl-enzyme at low pH. For the reverse reaction the rate determining step is a process associated with NADH binding, probably a conformation change, at high pH and d-glyceraldehyde 3-phosphate release at low pH. NADH has previously been shown to be a competitive inhibitor of the enzyme with respect to d-glyceraldehyde 3-phosphate and vice versa. This is consistent with the mechanism deduced from transient experiments given the additional proviso that 1-arseno-3-phosphoglycerate has a half-life of about 1min or longer at pH7. The dissociation constants of d-glyceraldehyde 3-phosphate and 1,3 diphosphoglycerate to the NAD(+)-bound enzyme are too large to measure but are nevertheless consistent with the low K(m) values of these substrates. PMID- 4332598 TI - Hypervitaminosis A dysmelia in rats. PMID- 4332599 TI - Infiltrating glomus tumour of lower limb. PMID- 4332600 TI - Pituitary tumours and hypopituitarism. PMID- 4332602 TI - Evoked responses to electrical stimulation of the auditory pathway during the wake-sleep cycle. PMID- 4332601 TI - Lipid alterations in apparently normal white matter in multiple sclerosis. PMID- 4332603 TI - Effect of polarizing currents on transcallosal postsynaptic potentials of cat pyramidal tract cells. PMID- 4332604 TI - Central monoamine oxidase inhibition and REM sleep. PMID- 4332605 TI - The neurochemical basis of REM sleep: a cholinergic mechanism responsible for rhythmic activation of the vestibulo-oculomotor system. PMID- 4332606 TI - Effect of intracellular injection of pyridine nucleotides on electrical responses of cat spinal motoneurones. PMID- 4332607 TI - Strontium and bone development under conditions of suboptimal vitamin D. PMID- 4332608 TI - Effect of the cell cycle on carcinogenesis. PMID- 4332609 TI - Duration of immunity in heifers inoculated with infectious bovine rhinotracheitis virus. PMID- 4332610 TI - Optic neuritis in dogs. PMID- 4332611 TI - Angiotensin and norepinephrine infusions during pregnancy: alterations in plasma epinephrine (E) and norepinephrine (NE). PMID- 4332612 TI - Sex steroids in adrenal effluent plasma of the ovariectomized rhesus monkey. PMID- 4332613 TI - Simultaneous assessment of growth hormone and ACTH reserve in children pretreated with diethylstilbestrol. PMID- 4332614 TI - A unique form of circulating insulin in human islet cell carcinoma. PMID- 4332615 TI - Competitive protein-binding radioassay for 25-hydroxycholecalciferol. PMID- 4332617 TI - Re-innervation of smooth muscle of the vas deferens transplanted into the anterior chamber of the eye. PMID- 4332616 TI - Studies on experimental mouse mastitis relative to the assessment of pharmaceutical substances. PMID- 4332618 TI - Comparison of accuracy between initial and delayed 99m Tc-pertechnetate brain scans. PMID- 4332619 TI - Fine structure alterations in canine lung transplants. PMID- 4332620 TI - Congenital cervical herniation of the lung. Report of a case. PMID- 4332622 TI - Double primary carcinomas of the lung. PMID- 4332621 TI - 1,25-Dihydroxycholecalciferol, a biologically active metabolite of vitamin D 3 . PMID- 4332623 TI - Virus-induced antigens. PMID- 4332624 TI - Morphometric evaluation of ultrastructural changes in type II alveolar cells of rat lung produced by bromhexine. PMID- 4332625 TI - Stereochemistry of hemes and other metalloporphyrins. AB - Metalloporphyrins, most notably the iron porphyrins, observe clearly defined, internally consistent, structural principles that promise to be fully applicable to the hemes in the several families of the hemoproteins. PMID- 4332626 TI - Hypertension of renal origin: evidence for two different mechanisms. AB - Antibody to angiotensin 11, or a specific peptide competitive inhibitor of angiolensin II, was used to investigate the role of the renin-angiotensin system in two types of renal hypertension in rats. The data indicate that angiotensin II is in fact critically involved in the pathogenesis of the form of renal hypertension in which one renal artery is clamped and the contralateral kidney is left in place, but that it probably plays no significant role in the maintenance of experimental renal hypertension in which the opposite kidney has been removed. PMID- 4332627 TI - Dopamine-sensitive adenyl cyclase: possible role in synaptic transmission. AB - An adenyl cyclase activated by low concentrations of dopamine has been found in the mammalian superior cervical sympathetic ganglion. The existence of this enzyme may account for the increased amount of adenosine 3',5' monophosphate associated with synaptic activity in the ganglion. The results suggest that the physiological effects of dopamine in the ganglion, and possibly elsewhere in the nervous system, may be mediated by stimulating the synthesis of adenosine 3',5' monophosphate. PMID- 4332628 TI - Gamma-aminobutyric acid antagonism and presynaptic inhibition in the frog spinal cord. AB - The convulsant alkaloid bicuculline blocked presynaptic inhibition, dorsal root potentials, primary afferent depolarization, and depolarizing effects of gamma aminobutyric acid on dorsal root terminals of the amphibian spinal cord, but did not block effects of other putative amino acid transmitters. These actions of bicuculline suggest that gamma-aminobutyric acid may be the transmitter involved in spinal presynaptic inhibition. PMID- 4332629 TI - Sperm flagella: autonomous oscillations of the contractile system. AB - Bull sperm are deactivated, losing all motility, when they are impaled or dissected with a microprobe. Loss of activity is due to the creation of a hole or break in the cell membrane. Uncoordinated contractile activity is retained if external adenosine triphosphate and adenosine diphosphate are present. When these substances are in the medium, coordinated wave motion can be initiated in impaled or dissected sperm by bending a segment of the flagellum. PMID- 4332630 TI - [Histochemical study of the histogenesis of bone neoplasms developing under the action of beryllium]. PMID- 4332632 TI - [Cytochemical study of skeletal tumors]. PMID- 4332631 TI - [Diagnosis of cervical cancer on the basis of a histochemical study of hydrolytic enzymes]. PMID- 4332633 TI - [Histochemical characteristics of the follicular and Ashkenazy cells of the thyroid gland and histogenetic bases for classification of thyroid neoplasms]. PMID- 4332635 TI - [Histochemical characteristics of giant-cell bone tumors]. PMID- 4332634 TI - [Human thyroid gland adenomas producing thyrocalcitonin]. PMID- 4332636 TI - [Enzymatic ATP hydrolysis in nuclei of neoplastic and normal cells]. PMID- 4332637 TI - [Mucopolysaccharide membrane in normal cells and cells transformed by SV40 virus]. PMID- 4332638 TI - [Enzymatic hydrolysis of ATP on the surface of neoplastic cells]. PMID- 4332639 TI - [Primary aldosteronism]. PMID- 4332640 TI - Ultrastructure of early cleavage stages and preimplantation in the rabbit. PMID- 4332641 TI - [Basal plate of the mature human placenta. II. Enzyme-histochemical studies of cryostat sections]. PMID- 4332643 TI - The enzyme-pathobiochemistry of intracranial processes. A contribution. PMID- 4332642 TI - [Studies on paraplacental and amniotic fluid transport in man. 4. Vernix caseosa and meconium]. PMID- 4332644 TI - [Hidradenoma of the vulva]. PMID- 4332645 TI - Intestinal alkaline phosphatase in patients with liver disease. PMID- 4332646 TI - Hepatic degeneration and dysfunction in Reye's syndrome. PMID- 4332647 TI - Myasthenia gravis and the thymus. PMID- 4332648 TI - [Ultrastructure and cytochemistry of central synapses]. PMID- 4332650 TI - [Serodiagnosis of arbovirus infections. I. Use of immunofluorescence for the quantitative determination of neutralizing antibodies]. PMID- 4332649 TI - Conversion of mevalonic acid into prenyl hydrocarbons as exemplified by the synthesis of squalene. PMID- 4332651 TI - Adsorbent techniques for the separation of antibody-bound from free peptide hormones in radioimmunoassay. PMID- 4332652 TI - Immunofluorescent identification of cells synthesizing human growth hormone in culture. PMID- 4332653 TI - Production of antibodies to ACTH for use in radioimmunoassay. PMID- 4332654 TI - Growth hormone response to rapid intravenous injection of various amounts of 1 24 ACTH. PMID- 4332655 TI - The effects of hypophysectomy on phosphorylase activity in adipose tissue and muscle. PMID- 4332656 TI - A rapid filter paper disk assay for picomole amounts of cyclic AMP using a cyclic AMP dependent protein kinase. PMID- 4332657 TI - The role of parathyroid hormone and thyrocalcitonin in altering plasma calcium levels and adrenocortical secretory rates. PMID- 4332658 TI - Inhibition by thyrocalcitonin (calcitonin) of the cyclic AMP-mediated stimulation of thymocyte proliferation by epinephrine. PMID- 4332659 TI - Insulin release from human foetal pancreas in vitro. PMID- 4332660 TI - On the flexibility of hydrocarbon chains in lipid bilayers. PMID- 4332661 TI - Polymerization of unprotected 2'-deoxyribonucleoside 5'-phosphates at elevated temperature. PMID- 4332662 TI - Cobalt. II. Tetraphenylporphyrin complex with carbon monoxide. PMID- 4332663 TI - Arrangement of the electric potential-generating redox chain in the mitochondrial membrane. PMID- 4332664 TI - Analytical chemical studies on steroids. LII. Studies on steroid conjugates. VII. Gas chromatography of steroid N-acetylglucosaminides. PMID- 4332665 TI - The relationship of human growth hormone and plasma tyrosine during sleep. PMID- 4332666 TI - Early adrenal response to ACTH; Plasma concentrations of pregnenolone, 17 hydroxypregnenolone, progesterone, and 17-hydroxyprogesterone. PMID- 4332667 TI - Estrogen production by trophoblastic tumors in tissue culture. PMID- 4332668 TI - Arginine-induced insulin release in relation to the cyclic AMP system in man. PMID- 4332669 TI - Plasma renin activity and aldosterone secretion in patients with acromegaly. PMID- 4332670 TI - Hyponatremia with low urinary aldosterone occurring in an old woman. PMID- 4332671 TI - Adrenal and ovarian contributions to the elevated free plasma androgen levels in hirsute women. PMID- 4332672 TI - Clinical, electron microscope and biochemical studies on a case of cementosis in Egypt. PMID- 4332673 TI - Synthesis and antiviral activities of adamantane spiro compounds. 1. Adamantane and analogous spiro-3'-pyrrolidines. PMID- 4332674 TI - Specificity of inhibition of coenzyme Q-enzyme systems by lipoidal benzoquinone derivatives. PMID- 4332675 TI - Studies on the properties of retinal alcohol dehydrogenase from the rat. PMID- 4332676 TI - On the dynamics of operant conditioning. PMID- 4332677 TI - [Role of the sympathetic factor in the pathogenesis of myocardial infarct and isoproterenol necrosis]. PMID- 4332678 TI - [Angiotensin resistance. Critical remarks on the so called Bartter syndrome]. PMID- 4332679 TI - [Nobel prize in physiology or medicine 1971: the action of hormones outlined]. PMID- 4332680 TI - Nephroblastoma: possible index cancer of childhood. PMID- 4332681 TI - An outbreak of gastro-enteritis among diners at a restaurant in the Dandenongs. PMID- 4332682 TI - [Current therapeutic trends in neoplastic pathology of the trophoblast. Notes on the literature]. PMID- 4332683 TI - [Substitutive therapy with gradual doses of estrogens]. PMID- 4332684 TI - [Treatment of the climacteric syndrome. Clinical data on the use of the association of chlordiazepoxide and conjugated estrogens (Menrium)]. PMID- 4332685 TI - [Normal course of a pregnancy exposed, in the second month, to mechanical maneuvers and actinic irradiation]. PMID- 4332687 TI - Cylindromatous carcinoma of the uterine cervix. A case report. PMID- 4332686 TI - Regulation of adenosine 3',5'-cyclic monophosphate metabolism in cultured neuroblastoma cells. PMID- 4332688 TI - [Effect of hemimandibulectomy on the remaining temporo-mandibular joint]. PMID- 4332689 TI - Metabolic clearance rate, urinary and plasma production rates of testosterone sulfate in man. PMID- 4332690 TI - A ten-year follow-up on a case of sympathetic ophthalmia. PMID- 4332691 TI - [Effect of phentolamine on the glucose metabolism in normal persons and patients with chronic kidney insufficiency]. PMID- 4332692 TI - Striatal dopamine release after amphetamine or nerve degeneration revealed by rotational behaviour. PMID- 4332693 TI - Postsynaptic supersensitivity after 6-hydroxy-dopamine induced degeneration of the nigro-striatal dopamine system. PMID- 4332694 TI - Adipsia and aphagia after 6-hydroxydopamine induced degeneration of the nigro striatal dopamine system. PMID- 4332695 TI - The measurement of skeletal maturity. PMID- 4332696 TI - Attributes of the radiographic standard of reference for the National Health Examination Survey. PMID- 4332697 TI - The essential characteristics of a rating system. PMID- 4332698 TI - A consideration of factors underlying the selection of methods in the assessment of skeletal maturity. PMID- 4332699 TI - Use of the Greulich-Pyle "Atlas of Skeletal Development of the Hand and Wrist" in a clinical context. PMID- 4332700 TI - The use of the Greulich-Pyle method in a longitudinal growth study. PMID- 4332701 TI - Reproducibility of rating stages of osseous development. (Tanner-Whitehouse system). PMID- 4332702 TI - Comparison of Tanner-Whitehouse and Greulich-Pyle methods in a large scale Danish Survey. PMID- 4332703 TI - Tanner-Whitehouse and Greulich-Pyle skeletal age velocity comparisons. PMID- 4332704 TI - Bone age: its contribution to the prediction of maturational or biological age. PMID- 4332705 TI - Choice of area for assessment. PMID- 4332706 TI - Single versus serial assessment of skeletal age: either, both or neither? PMID- 4332707 TI - Skeletal maturity indicators in infancy. PMID- 4332708 TI - Problems in combining skeletal age for an individual. PMID- 4332709 TI - Skeletal growth in school children: maturation and bone mass. PMID- 4332710 TI - The value of an assessment of skeletal maturity in orthodontic diagnosis. PMID- 4332711 TI - Comparability in skeletal maturation research. PMID- 4332712 TI - Dysharmonic maturation of the hand in the congenital malformation syndromes. PMID- 4332713 TI - Assessment of skeletal age in short and tall children. PMID- 4332715 TI - Skeletal maturation of children in Shiraz, Iran. PMID- 4332714 TI - Some aspects of the analysis of hand-wrist bone-age readings. PMID- 4332716 TI - Skeletal development of non-institutionalized children with low Intelligence Quotients. PMID- 4332717 TI - Assessment of skeletal maturation. Summary. PMID- 4332718 TI - Cytochrome c-linked reactions in Rhodopseudomonas palustris grown photosynthetically on thiosulfate. PMID- 4332720 TI - An expeditious method for determining the activation energies of enzymatic reactions. PMID- 4332719 TI - Studies on the mitochondrial oligomycin-insensitive ATPase. II. The relationship of the specific protein inhibitor to the ATPase. PMID- 4332721 TI - Water structure and the chaotropic properties of haloacetates. PMID- 4332722 TI - Ion transport by heart mitochondria. 23. The effects of lead on mitochondrial reactions. PMID- 4332723 TI - Properties of the glyceraldehyde-3-phosphate dehydrogenase from Ehrlich ascites tumor cells. PMID- 4332725 TI - The synthesis of L-glucose by plant enzyme systems. PMID- 4332724 TI - Metabolism of vitamin B 6 in the I-strain mouse. II. Oxidation of pyridoxal. PMID- 4332726 TI - Activation of fructose diphosphatase by manganese, magnesium and cobalt. PMID- 4332727 TI - Effect of N,N'-dicyclohexylcarbodiimide (DCCD) on electron transport particles of Mycobacterium phlei. PMID- 4332728 TI - Studies on poly(adenosine diphosphate-ribose). XI. Purification of poly(adenosine diphosphate-ribose) on a hydroxylapatite column. PMID- 4332729 TI - Resolution and reconstitution of the succinoxidase pathway of Mycobacterium phlei. PMID- 4332731 TI - Kinetic evidence for a binary complex isomerization in the liver alcohol dehydrogenase reaction mechanism. PMID- 4332730 TI - Conversion of "neutral" to "alkaline" fructose 1,6-diphosphatase by controlled digestion with papain. PMID- 4332732 TI - Corticotropin therapy in patients with myasthenia gravis. Electrophysiologic, pharmacologic studies. PMID- 4332733 TI - Pick's disease. A clinical and ultrastructural study. PMID- 4332734 TI - Blood clearance rate as an adjunct to the 198 Au hepatoscan. PMID- 4332735 TI - Adrenal corticosteroids--physiological considerations. PMID- 4332736 TI - Effects of local cooling upon conduction and synaptic transmission. PMID- 4332737 TI - Penicillin and presynaptic inhibition in the amphibian spinal cord. PMID- 4332738 TI - [The influence of stimulation and inhibition of the beta-adrenergic receptors on the metabolism of the myocardial cell]. PMID- 4332739 TI - [Pediatrics--an important partner for geriatrics?]. PMID- 4332740 TI - Morphological and biochemical study in x-ray- and dibutyryl cyclic AMP-induced differentiated neuroblastoma cells. PMID- 4332741 TI - Cell-substrate adhesivity. A determinant of cell motility. PMID- 4332742 TI - Changes in interscapular brown adipose tissue of rat during perinatal and early postnatal development and after cold acclimation. IV. Morphometric investigation of mitochondrial membrane alterations. PMID- 4332744 TI - G-6-PD and PGM phenotypes of 16 continuous human tumor cell lines. Evidence against cross-contamination and contamination by HeLa cells. PMID- 4332743 TI - [Secretion of corticotropin and somatotropin during the insulin test in partial hypopituitarism]. PMID- 4332745 TI - Analog computer model for the ACTH-glucocorticoid system. PMID- 4332746 TI - Professional pharmacy functions in community mental health centers. PMID- 4332747 TI - Pathogenesis of acute renal failure. PMID- 4332748 TI - Chemical studies of potential relevance to penicillin hypersensitivity: the fate of benzylpenicillenic acid in aqueous buffer solutions. PMID- 4332749 TI - Angiotensin tachyphylaxis in guinea-pig aortic strips. PMID- 4332750 TI - Release of catecholamines during the induction of and recovery from tachyphylaxis to angiotensin II. PMID- 4332751 TI - Interaction between angiotensin and neurally released norepinephrine on the cat nictitating membrane in vivo. PMID- 4332753 TI - Spontaneous and evoked quantal transmitter release at a vertebrate central synapse. PMID- 4332752 TI - [The use of L-asparaginase in the treatment of acute lymphoblastic leukemia in childhood]. PMID- 4332754 TI - Effect of ketone bodies on hormone-, theophylline- and dibutryl cyclic AMP induced lipolysis and on cyclic AMP-phosphodiesterase. PMID- 4332755 TI - Effects of nicotinic acid on hormone-, theophylline- and dibutyryl cyclic AMP induced lipolysis and on cyclic AMP phosphodiesterase. PMID- 4332756 TI - [Studies on the metabolism of L-chain polypeptide of immunoglobulin in various dys- and paraproteinemic disorders]. PMID- 4332757 TI - Ultrastructural and biochemical alterations of rat hepatocytes produced by chronic protein deficiency and re-alimentation. PMID- 4332758 TI - Common antigen in meningioma-derived cell cultures. AB - Serums of patients with intracranial meningiomas reacted in immunofluorescence assays with cell cultures and tumor imprints prepared from human meningiomas. Antibody in these serums appears to be specific for antigens in meningioma tissue and shows some cross-reactivity with neoplastic tissue of glial origin. PMID- 4332759 TI - Human sarcomas contain RNA related to the RNA of a mouse leukemia virus. AB - Labeled DNA complementary to the RNA of the Rauscher leukemia virus was hybridized with RNA from the polysome fraction of human sarcomas. Eighteen out of 25 specimens contained RNA possessing homology to the RNA of the mouse leukemia virus but not to that of the unrelated viruses causing mammary tumors in mice or myeloblastosis in chickens. Further, no normal adult or fetal tissues showed significant amounts of RNA specific to mouse leukemia virus. It appears that human sarcomas contain RNA sequences homologous to those found in an agent related to a virus known to cause sarcomas in mice. PMID- 4332760 TI - Cellular site of glucocorticoid-receptor complex formation. AB - The cellular site of binding of dexamethasone by specific glucocorticoid receptors in cultured hepatoma cells was investigated with the use of certain mercurials. p-Chloromercuribenzene sulfonate and p-chloromercuribenzoate inhibit the binding of steroid by receptors in cell-free extracts, but they allow the steroid-receptor complex to form in whole cells. In contrast, HgCl(2) inhibits binding both in extracts and cells. Since both organic mercury compounds, unlike HgCl(2), do not readily enter intact cells, it appears that the specific steroid binding occurs inside the cell rather than at the cell membrane. PMID- 4332761 TI - Gonadotropin secretion during sleep in normal adult men. AB - Release of luteinizing hormone and follicle stimulating hormone during sleep in young adult men occurred in unrelated, random, arrhythmic peaks, with no consistency from night to night in the same subject. Release of luteinizing hormone was modestly but significantly larger (14 perecnt) during rapid-eye movement sleep than it was in non-REM sleep, but release of follicle stimulating hormone was not clearly related to stages of sleep. PMID- 4332762 TI - Morphological transformation in vitro of human fibroblasts by Epstein-Barr virus: preliminary observations. AB - Human embryo fibroblasts have undergone morphological transformation in vitro after infection by Epstein-Barr virus. The fibroblasts were maintained in suspension during exposure to the virus, and further treatment with inactivated Sendai virus increased the transformation rate. The transformed cells were large and polygonal and grew in discrete, heaped up, foci. PMID- 4332763 TI - Effects of oral contraceptives on phospholipids of human cervical mucus. PMID- 4332764 TI - Biochemical composition and in vitro uptake of estradiol 6,7- 3 H by the fallopian tube: a preliminary study. PMID- 4332765 TI - Familial ovarian hyperthecosis. PMID- 4332766 TI - Bioenergetics and the problem of tumor growth. PMID- 4332767 TI - [Paradoxical sleep in depressed patients. Effects of methaqualone and pentobarbital]. PMID- 4332768 TI - Ionic base radicals in -irradiated DNA. PMID- 4332769 TI - Regulation of the biosynthesis of valyl-tRNA synthetase in yeast. PMID- 4332770 TI - Selective inhibition by cycloheximide of ribosomal RNA synthesis in chlorella. PMID- 4332771 TI - [Oestradiol receptor, cyclic 3',5'-AMP and nucleolar RNA polymerase in calf uteri. Stimulation of RNA biosynthesis in vitro]. PMID- 4332772 TI - Studies on the RNA-binding activity of rat liver cytosol. PMID- 4332773 TI - [Study of a specific antigen of human colonic tumors of embryonic origin]. PMID- 4332774 TI - A new anti-asthmatic drug (ICI 58 301): blood levels and spirometry. PMID- 4332775 TI - Pharmacokinetic model for the successive demethylation and biliary secretion of methyl orange in the rat. AB - 1. A one-compartment pharmacokinetic model was developed in which a drug underwent two successive metabolical reactions (for example, metabolism followed by conjugation) and free drug and both metabolites were excreted.2. Techniques were described whereby graphical estimates of the first-order rate constants may be derived from cumulative excretion data on the drug and its metabolites. Computer simulation techniques were used to show that the experimental data permit reasonably accurate estimation of the rate constants of the model by graphical and computer methods.3. Tritiated methyl orange (2 mg) was administered to five groups of six rats with biliary cannulation. The bile produced by each animal was collected at hourly intervals for 6 h and the amounts of methyl orange and its metabolites, 4'sulpho-4-methylaminoazobenzene and 4'sulpho-4 aminoazobenzene, determined by thin layer chromatography and radioactive counting techniques.4. The data were analysed graphically and with an iterative digital computer programme to yield the first-order rate constants for the successive demethylation steps in the metabolism of methyl orange. The removal of the first methyl group had a rate constant of 0.684+/-0.142 h(-1) (+/-S.D.) and the second methyl group 1.00+/-0.302 h(-1). The rate constant for biliary excretion of the free methyl orange was 0.164+/-0.042 h(-1), for the monomethyl derivative 0.672+/ 0.461 h(-1), and for the demethylated metabolite 6.413+/-3.222 h(-1). PMID- 4332777 TI - Aetiology of liver cancer. PMID- 4332776 TI - Inhibition of angiotensin I converting enzyme by venom peptides. AB - The synthetic analogues of three naturally occurring peptides from the venom of Bothrops jararaca have been tested as inhibitors of angiotensin converting enzyme activity in two systems. They have widely differing absolute potencies but the relative potencies are similar in the two systems. The high inhibitory potency of the nonapeptide is compatible with a non-competitive type of inhibition. PMID- 4332778 TI - Herpes genitalis. PMID- 4332779 TI - Diabetes insipidus with an ACTH-secreting carcinoma of the bronchus. PMID- 4332780 TI - Solitary myeloma with peripheral polyneuropathy--recovery after treatment. PMID- 4332781 TI - Metal ions bound to phospholipids after isolation by silicic acid column chromatography. PMID- 4332782 TI - Membrane properties of saturated fatty acid mutants of yeast revealed by spin labels. PMID- 4332783 TI - Protein-protein and protein-lipid interactions in human serum high-density lipoprotein: an analysis by a spin label method. PMID- 4332784 TI - A study of various electrophoretic and inhibition techniques for separating serum alkaline phosphatase isoenzymes. PMID- 4332786 TI - [Morgagni-Morel syndrome-differential diagnosis and clinical evaluation]. PMID- 4332785 TI - The role of angiotensin II in the control of aldosterone in man. PMID- 4332787 TI - [The structure of thyrotropin releasing factor is solved]. PMID- 4332788 TI - [Nobel Prize in physiology and medicine 1971. Cyclic AMP--endocrinology at the cellular level]. PMID- 4332789 TI - [Subcellular particles in tumors. I. Intracellular distribution of cytochrome oxidase, glucose-6-phosphatase, catalase, and several acid hydrolases in a transplantable chemically induced heatoma (hepatoma HW)]. PMID- 4332790 TI - [Subcellular particles in tumors. II. Analysis of mitochondrial and microsomal fractions in hepatoma HW by isopycnic centrifugation]. PMID- 4332791 TI - Genetic control of the synthesis of repressible phosphatases in Neurospora crassa. PMID- 4332792 TI - The microsomal fraction from Tetrahymena pyriformis strain ST: characterization and subfractionation. PMID- 4332794 TI - Synergism between polymyxin and polysorbate 80 against Pseudomonas aeruginosa. PMID- 4332793 TI - Oxygen and the growth and metabolism of Clostridium acetobutylicum. PMID- 4332796 TI - Diphenylhydantoin and the beta cell. PMID- 4332795 TI - A symmetrical model for polyoma virus DNA replication. PMID- 4332797 TI - More on levodopa--implications for adrenal function. PMID- 4332798 TI - Cyclic AMP and LATS. PMID- 4332800 TI - Regulation of cell motility by cyclic AMP. PMID- 4332799 TI - Presence in human breast cancer of RNA homologous to mouse mammary tumour virus RNA. PMID- 4332801 TI - Is a specific protein responsible for the supercoiling of polyoma DNA? PMID- 4332802 TI - Immunological characterization of primate C-type virus reverse transcriptases. PMID- 4332803 TI - Evidence for SV40 specific RNA containing virus and host specific sequences. PMID- 4332804 TI - Origin and possible mode of action of a tissue antagonist of interferon. PMID- 4332805 TI - Bell's palsy. PMID- 4332806 TI - [Clinical evaluation of the efficacy of Tebrofen in viral infections of the eye]. PMID- 4332807 TI - [Cystosarcoma phyllodes of the mammary gland]. PMID- 4332808 TI - DNA in uninfected and virus-infected cells complementary to avian tumor virus RNA. AB - The 70S RNA component of several avian tumor viruses was hybridized with DNA extracted from avian tumor virus-infected and uninfected chicken and Japanese quail cells. Tritium-labeled 70S RNAs from Rous sarcoma virus (RSV), Rous associated virus-1 (RAV-1), RAV-60, and Schmidt-Ruppin-RSV (SR-RSV) hybridize from 3 to 10 times more with DNA from uninfected chicken cells than with DNA from Escherichia coli, calfthymus, or baby hamster kidney cells. After infection of chicken cells with RSV(RAV-1), SR-RSV, or RAV-2, the amount of 70S avian tumor virus [(3)H]RNA hybridized increases by 1.6 times. The specificity of the hybridization reaction was shown by the specific competition of 70S SR-RSV [(3)H]RNA with 70S RNA from RSV(RAV-1), and not with RNA from Sendai virus or chicken cells. There was no difference in the hybridization of 70S RNA from RSV (RAV-1), RAV-1, or RAV-60 with DNA either from chicken cells that contain RAV-60 in a nonreplicating form or from chicken cells that do not appear to contain RAV 60. These results indicate that both types of uninfected chicken cells contain DNA that is complementary to RNA from several avian tumor viruses and that the amount of complementary DNA increases in such cells after infection with an avian tumor virus. The RNAs of genetically different avian tumor viruses appear to have indistinguishable base sequences by this technique. PMID- 4332809 TI - DNA and gene therapy: transfer of mouse DNA to human and mouse embryonic cells by polyoma pseudovirions. AB - It was demonstrated previously that polyoma pseudovirions (DNA fragments encapsidated by polyoma virus coats) are adsorbed to and uncoated by mouse-embryo cells. 24 hr after infection of secondary mouse-embryo cells with [(3)H]thymidine labeled pseudovirus, 24% of the total radioactivity found in cells occurred in the nuclear fraction. This nuclear radioactivity represents pseudovirus DNA, as shown by its hybridization with mouse-embryo DNA. Since much of the radioactive material found in the nuclear fraction is sensitive to pancreatic DNase, it is available as uncoated DNA.24 hr after infection of human embryo cells with [(3)H]thymidine-labeled pseudovirions, 7% of the total cellular radioactivity is found in the nuclear fraction of the cells. That this radioactivity represents uncoated pseudoviral DNA was shown by sedimentation of the disrupted nuclear fraction through a neutral sucrose gradient. The pseudoviral DNA in the nuclear fraction has been nicked to some extent, as shown by the heterogeneity of the peaks found after sedimentation of the disrupted nuclear fraction through alkaline sucrose. The experiments demonstrate that polyoma pseudovirions deliver DNA to human cells. PMID- 4332810 TI - Helper activity of human leukemic tissue extracts for leukemia virus expression in mice. AB - Extracts of cultured human leukemic tissues increased the spleen focus-forming activity of Friend leukemia virus preparations in BALB/c and other partially resistant mice. Such mice carry the Fv-1(b) gene, which inhibits the expression of helper virus indigenous to the Friend virus complex, and allows co-infecting leukemia viruses of mice, cats, or chickens to substitute for the inhibited helper virus and increase the expression of the spleen focus-forming virus. The helper activity of extracts from human leukemic tissues shared several important properties with that associated with known leukemogenic viruses of animals. PMID- 4332811 TI - Interaction of the subunits of adenosine 3':5'-cyclic monophosphate-dependent protein kinase of muscle. AB - Two cAMP-dependent protein kinases purified from rabbit skeletal muscle were shown to bind the same amount of cAMP per unit of enzyme activity at several concentrations of this nucleotide. A preparation containing both of these kinases was separated into catalytic (C) and regulatory (R) subunit fractions in the presence of cAMP, the regulatory subunit being obtained as an R.cAMP complex. Addition of increasing amounts of the R.cAMP complex to the holoenzyme (RC) increased the concentration of cAMP required for half-maximal activity of the enzyme. cAMP was liberated from the R.cAMP complex in the presence of added catalytic subunit in a reaction that was facilitated by Mg(2+), ATP, and warming. These findings are presented in support of a model for activation of the protein kinase by cAMP. The possibility that excess regulatory subunit may serve as a sink for intracellular cAMP is also discussed. It is shown that cAMP bound to the R subunit is not a substrate for the cAMP phosphodiesterase. PMID- 4332812 TI - Comparative properties of RNA and DNA templates for the DNA polymerase of Rous sarcoma virus. AB - Several natural RNAs were compared with respect to their template activities for the DNA polymerase of Rous Sarcoma Virus during a 2-hr incubation period. 60-70S viral RNA was found to be a 5- to 10-fold better template than heat-dissociated Rous viral RNA, influenza virus RNA, tobacco mosaic virus RNA, or ribosomal RNA. Denatured salmon DNA is a little better, and poly(dAT) is 2-4 times better as a template for the enzyme than is 60-70S Rous viral RNA. The 60-70S RNAs of different strains of avian tumor viruses have very similar template activities for a given avian tumor virus DNA polymerase. Oligo(dT) or oligo(dC) were found to enhance the template activity of heat-dissociated Rous viral RNA 20- to 30 fold, and that of other natural RNAs tested one- to several-fold. DNA syntheses of 1-24% were obtained during a 2-hour incubation of the enzyme with the above RNA templates. The results suggest that the enzyme prefers partially doublestranded or hybrid regions of RNAs for optimal DNA synthesis, but certain regions of single-stranded RNA can also serve as templates.Poly(dAT) competes with viral RNA for purified DNA polymerase during DNA synthesis, as would be expected if RNA- and DNA-dependent DNA synthesis was performed by at least one common active site of the same enzyme. PMID- 4332813 TI - Pituitary peptides and the suppression of memory by puromycin. AB - It has previously been shown that the expression of memory of maze-learning in mice is blocked by intracerebrally-injected puromycin one or more days after the training experience, and that bilateral adrenalectomy before training protects memory against this effect of puromycin. Purified cortrophin gel, injected subcutaneously up to 3 days before training, has now been found to give results like those obtained with adrenalectomy and, additionally, to provide a high degree of protection when injected up to 16 hr after training. Several possible explanations for these effects have been considered and found to be inadequate. PMID- 4332814 TI - Characterization of the inducer required for the development of macrophage and granulocyte colonies. AB - A substance produced by various types of cells can induce from single hematopoietic cells the formation of colonies of normal macrophages and granulocytes. This inducer has been purified 600-fold from serum-free conditioned medium from a tissue culture line of mouse cells. It is shown that the inducer is a protein, with a molecular weight of 65-70,000, whose inducing activity was about 1 ng per colony. Acrylamide gel electrophoresis of this material gave four bands, only one of which contained inducing activity. The purified protein was inactive. Activity was regained by the addition of a low molecular weight cofactor that is present in conditioned medium. Under certain conditions, activity was also regained by the addition of adenosine 3':5'-cyclic monophosphate (cyclic AMP). PMID- 4332815 TI - Lateral diffusion of phospholipids in a vesicle membrane. AB - Nuclear-resonance spectra of phosphatidylcholine (PC) vesicles are broadened by spin-labeled PC. The broadening of the N-methyl proton line is proportional to spin-labeled PC concentration; the broadening by 1 molecule in 100 of spin labeled PC is 9.7 Hz at 35 degrees C; the broadening is not due to collisions between vesicles, exchange of spin label between vesicles, or fusion of vesicles. These findings are proof of rapid diffusion in the plane of the PC bilayer (lateral diffusion). A further study of the broadening reveals the molecular frequency of the translation step for lateral diffusion to be much greater than 3 x 10(3) sec(-1) at 0 degrees C. PMID- 4332816 TI - In vitro reassembly of shell-like particles from disrupted polyoma virus. AB - When purified polyoma virus is exposed to 0.01 M dithiothreitol in the presence of 0.2 M Na(2)CO(3)-NaHCO(3) (pH 10.6) at 0-4 degrees C, the capsids are rapidly disrupted to protein subunits of capsomere size, as judged by density gradient centrifugation, sedimentation equilibrium centrifugation, and electron microscopy. Hemagglutination activity and infectivity of disrupted virus are reduced to below detectable amounts. Removal of the disruption reagents by dialysis at 4 degrees C against 0.05 M Tris-0.14 M NaCl-1 mM EDTA and 0.1 mM 2 mercaptoethanol (pH 8.0) results in a time-dependent reappearance of up to 17% of the starting hemagglutination titer, under optimum conditions of ionic strength, pH, temperature, and virus protein concentration. The recovered hemagglutination activity is found in glycerol gradients associated with a 100S DNA-protein complex consisting mostly of linear aggregates of capsomeres. When the linear complex is treated with pancreatic DNase, the complex is converted into spherical particles, of approximately virus size, that sediment at 140 S (with aggregates at 180 S), as well as on the cushion of half-saturated CsCl at the bottom of the gradients. All reassembled particles are not infectious and have markedly reduced DNA to protein ratios. PMID- 4332817 TI - Spin-labeled electron spin resonance study of the lipid-containing membrane of influenza virus. AB - The organization of the lipid-containing membrane of influenza virus has been studied by the use of three different lipid spin labels, and the results are compared with a parallel study on human erythrocyte ghosts. The lipid phase of the viral membrane is slightly more rigid than that of the erythrocyte ghosts. The data suggest that the viral lipid is arranged in a bilayer. The data suggest that the viral lipid is arranged in a bilayer. The glycoprotein spikes covering the viral membrane were specifically removed by proteases, and no alteration in the environment of any of the three spin labels was detected. This suggests that the spikes are not involved in determining the organization of the lipid bilayer. PMID- 4332819 TI - [Informative value of standard urography]. PMID- 4332818 TI - [The effect of corticotropin on reginal blood circulation]. PMID- 4332820 TI - Cyclic adenosine monophosphate stimulation of axonal elongation. AB - Elevated concentrations of adenosine 3',5'-monophosphate induce a variety of cell movements. The role of adenosine 3',5'-monophosphate in promoting those movements associated with growth prompted our study of in vitro microtubule-dependent axonal elongation. Ganglia treated with adenosine 5'-monophosphate show no enhancement over controls; treatment with adenosine 3', 5'monophosphate or its dibutyryl derivative significantly enhances elongation, as measured by increases in both axonal numbers and length. Our study suggests that adenosine 3',5' monophosphate promotes elongation by stimulation of microtubule assembly. PMID- 4332821 TI - DNA of Rous sarcoma virus: its nature and significance. AB - Purified preparations of Rous sarcoma virus (an avian tumor virus with an RNA genome) contain small amounts of double-stranded DNA. This DNA cannot be hybridized to viral RNA, but will reanneal completely with the DNA of avian cells. Extensive substitution of bromodeoxyuridine for thymidine in "viral" DNA does not photosensitize the biological activity of the virus. These observations indicate that the DNA associated with Rous sarcoma virus is derived from the DNA of the avian host cell, and is probably devoid of any function in the life cycle of the virus. PMID- 4332822 TI - Detection of high-molecular-weight RNA in particles from human milk. AB - Particles from human milk contain a reverse transcriptase and a high-molecular weight (60S to 70S) RNA that serves as a template. These particles have two features diagnostic of known RNA tumor viruses. PMID- 4332823 TI - Modulation of adenylate cyclase activity in liver and fat cell membranes by insulin. AB - Insulin depresses both the activity of adenylate cyclase stimulated by glucagon, epinephrine, and sodium fluoride in liver cell membranes and the activity of adenylate cyclase stimulated by epinephrine and adrenocorticotropin in particulate preparations from homogenates of isolated fat cells. Significant inhibition is detected with very low concentrations (10(-11) molar) of insulin but not with unphysiologically high (10(-9)molar) concentrations of the hormone. These direct effects of insulin on an enzymatic system in broken-cell preparations suggest a fundamental role of adenylate cyclase activity and of cyclic adenosine monophosphate in the mechanism of action of insulin. PMID- 4332824 TI - Anti-poliomyelitis campaign in Taiwan. PMID- 4332825 TI - Edwardsiella tarda in jungle diarrhoea and a possible association with Entamoeba histolytica. PMID- 4332826 TI - Infantile diarrhoea in a population of low socio-economic group. PMID- 4332827 TI - [Neurosurgical treatment of cardiac pain syndromes associated with irritation of a spinal nerve]. PMID- 4332828 TI - [Pathologo-anatomical studies in reduction abnormalities of the lower extremities]. PMID- 4332829 TI - A gravimetric system to study adsorption on fine powders. PMID- 4332830 TI - Influence of filler materials on air contamination in manual electric arc welding. PMID- 4332832 TI - The cytology of Hansenula. 3. Nuclear segregation and envelopment during ascosporogenesis in Hansenula wingei. PMID- 4332831 TI - [Synthesis of C 4 -dicarboxylic acids from pyruvate by Hydrogenomonas eutropha strain H16]. PMID- 4332834 TI - Terminal oxidations in Bacillus brevis ATCC 10068. 3. Evidence of TCA cycle enzyme activity. PMID- 4332833 TI - [Metabolic rhythms of aerobic yeasts]. PMID- 4332835 TI - Glycoprotein biosynthesis. IV. Activities of enzymes involved in glucosamine metabolism in the bovine thyroid gland. PMID- 4332836 TI - Identification of N,O-diacetyl-,N-acetyl-, and N-glycolylneuraminyl-(2-3)-lactose in rat urine. PMID- 4332837 TI - A comparison of rat and human liver formaldehyde dehydrogenase. PMID- 4332838 TI - Rapid gibberellin responses and the action of adenosine 3',5'-monophosphate in aleurone layers. PMID- 4332839 TI - Characteristics of the hormonal induced cyclic adenosine 3',5'-monophosphate response in the rat and guinea pig lung in vitro. PMID- 4332840 TI - Effects of catecholamines and monovalent cations on adenylate cyclase activity in cultured glial tumor cells. PMID- 4332841 TI - Gonadotrophin stimulation of testosterone production by the rat testis in vitro. PMID- 4332842 TI - Simulatory effects of gonadotropins on the formation of cyclic adenosine 3',5' monophosphate by porcine granulosa cells. PMID- 4332843 TI - The inhibitory activity of distamycin A on X14, H-1 and polyoma viruses multiplication. PMID- 4332845 TI - Acid mucopolysaccharides in calcified tissues. PMID- 4332846 TI - The chromatographic separation of mixtures of benzodiazepine drugs. PMID- 4332844 TI - Immunofluorescent detection of TRIC agents from the genital tract of healthy pregnant women. PMID- 4332847 TI - Experimental effects of hyperbaric oxgen on selected clostridial species. I. In vitro studies. PMID- 4332848 TI - Experimental effects of hyperbaric oxygen on selected clostridial species. II. In vitro studies in mice. PMID- 4332849 TI - Tardy ulnar palsy. A review of 62 cases and discussion of current concepts. PMID- 4332850 TI - Studies on the pathogenesis of multiple sclerosis. 2',3'-Cyclic nucleotide 3 phosphohydrolase as marker of demyelination and correlation of findings with lysosomal changes. PMID- 4332851 TI - Herpes Zoster. Demonstration of virus in trigeminal nerve and ganglion by immunofluorescence and electron microscopy. PMID- 4332852 TI - Excitation of Renshaw cells in relation to orthodromic and antidromic excitation of motoneurons. PMID- 4332853 TI - Changes in correlation between monosynaptic responses of single motoneurons and in information transmission produced by conditioning volleys to cutaneous nerves. PMID- 4332854 TI - Hydroxylysine metabolism in rats, mice, and chickens. PMID- 4332856 TI - The permeability of the parietal layer of Bowman's capsule. PMID- 4332855 TI - Phosphorus deprivation: the metabolism of vitamin D 3 and 25 hydroxycholecalciferol in rats. PMID- 4332857 TI - Respiratory enzyme activity and mitochondrial morphology of L-cells under prolonged oxygen deprivation. PMID- 4332858 TI - Mechanism of demyelination in tellurium neuropathy. Electron microscopic observations. PMID- 4332859 TI - Bone lesions produced by feline herpesvirus. PMID- 4332860 TI - Change in type of Bekesy audiogram in acoustic neuroma. PMID- 4332861 TI - [Clinical and pharmacotherapeutic value of cyclic AMP]. PMID- 4332862 TI - The effect of urethane anesthesia on the cardiovascular action of angiotensin II. PMID- 4332863 TI - Effects of centrally administered angiotensin II on salt and water excretion. PMID- 4332864 TI - Sleep, psychological and clinical changes during alcohol withdrawal in NAD treated alcoholics. PMID- 4332865 TI - Observations on the effect of intracerebral microinjections of a cholinergic agent on behavior and on release of adrenocorticotrophic hormone. PMID- 4332866 TI - Inhibition of interferon synthesis in mammalian cell cultures after nickel treatment. PMID- 4332867 TI - [X-ray diagnosis of mammary gland diseases in men]. PMID- 4332868 TI - [Surgical diseases of the diaphragm]. PMID- 4332869 TI - [Survival of poliomyelitis virus and several other intestinal viruses in curds]. PMID- 4332870 TI - The ultrastructure of the ovarian follicle of medaka, Oryzias latipes. PMID- 4332871 TI - [Cortico-pial junction and the mode of entry of blood vessels into the cerebral cortex in man. Structure and ultrastructure]. PMID- 4332872 TI - [Glycogen-rich cells in the lateral ventricle ependyma of the rat brain. Optical and electromicroscopical study]. PMID- 4332873 TI - The comparative physiology of gamete populations. PMID- 4332874 TI - [Experiences with synthetic ACTH drugs]. PMID- 4332875 TI - [Bacterial association in acute ulcerative rectocolitis of amebic origin]. PMID- 4332876 TI - [Bacteriological study of hepatic abscess in patients and in hamsters]. PMID- 4332877 TI - [Proliferative lesion of the wall of the colon produced by Entamoeba histolytica]. PMID- 4332878 TI - [Trophozoites of Entamoeba histolytica in material from patients with liver abscess]. PMID- 4332879 TI - [Advances in the study of the enzyme activity of Entamoeba histolytica]. PMID- 4332880 TI - [Morphology of Entamoeba histolytica in culture media]. PMID- 4332881 TI - [Morphology of Entamoeba histolytica in liver abscess in hamsters]. PMID- 4332882 TI - [Morphological changes in Entamoeba histolytica under the effect of emetine hydrochloride in vitro]. PMID- 4332883 TI - [Immunoelectrophoresis of the axenic amebic antigen in the presence of serum from patients with amebic hepatic abscess]. PMID- 4332884 TI - [Advances in methods of Entamoeba histolytica culture]. PMID- 4332885 TI - [Electron microscopy studies on Paget's disease of breast]. PMID- 4332886 TI - [Electrotherapy in neurology]. PMID- 4332887 TI - [Primary-inflammatory, metabolic and vascular polyneuritis]. PMID- 4332888 TI - [Principles and limits of ACTH-cortisone therapy in neurology]. PMID- 4332889 TI - Treatment of the Guillain-Barre syndrome. PMID- 4332891 TI - Pseudotuberculoma granulosum silicoticum. PMID- 4332892 TI - [Long-term recording of cerebral, muscular and ocular electric activities in mice]. PMID- 4332890 TI - [Inflammatory diseases of the nervous system. Therapy of encephalitis and myelitis]. PMID- 4332893 TI - [Effects of sleep deprivation on the incorporation of labelled amino acids into cerebral proteins in rats]. PMID- 4332894 TI - [Action of high doses of cholecalciferol on hepatic and renal mitochondria in rats]. PMID- 4332895 TI - The metabolism of 3 H-labelled estrone by the isolated perfused liver of the rabbit, chicken, and guinea pig. PMID- 4332896 TI - Effect of oxygen on freezing damage. 3. Modification by -mercaptoethylamine. PMID- 4332897 TI - Predictors of premature termination of outpatient-followup group psychotherapy among male alcoholics. PMID- 4332898 TI - Nasopharyngeal carcinoma in non-Chinese populations with special reference to south-east Asia and Africa. PMID- 4332899 TI - The establishment of lymphoblastoid lines from adult and fetal human lymphoid tissue and its dependence on EBV. PMID- 4332900 TI - Epstein-Barr virus (EBV)-associated antibody patterns in malignant lymphoma and leukemia. II. Chronic lymphocytic leukemia and lymphocytic lymphoma. PMID- 4332901 TI - Tumor induction in hamster by para(3cT)-adenovirus 7 mutant. Morphology and antigenic profiles of neoplastic cells. PMID- 4332902 TI - Protein catabolism: activities of three proteolytic enzymes in a synchronized L5178Y mouse leukemic cell line. PMID- 4332903 TI - Internal symmetries of the histone F 2b molecule and several other polypeptide sequences. Implications for the genesis and development of genetic information. PMID- 4332904 TI - A clinical and experimental comparative study of sodium colistimethate and polymyxin B sulfate. PMID- 4332906 TI - The ultrastructure of trophozoites of Entamoeba histolytica with particular reference to spherical arrangements of osmiophilic cylindrical bodies. PMID- 4332907 TI - Ultrastructure of the "cyst-like bodies" of Trypanosoma conorhini. PMID- 4332905 TI - Activation and inhibition of mitochondrial adenosine triphosphatase by various anions and other agents. PMID- 4332908 TI - [Electroencephalographic studies in hypophyseal dwarfism in childhood]. PMID- 4332909 TI - Pituitary-adrenal function in rats with diencephalic islands. PMID- 4332910 TI - [Urography in the diagnosis of Wilms' tumors in children]. PMID- 4332911 TI - Absence of a cell membrane alteration function in non-transforming mutants of polyoma virus. AB - A surface receptor for an agglutinin, exposed in transformed but not in normal cells, arises in normal mouse cells during lytic infection by polyoma virus. The structural change in the surface membrane characteristic of transformed cells and of cells productively infected by wild type virus fails to occur in normal mouse cells infected by mutants of the virus that are unable to cause transformation. The exposure of the receptor site by wild type virus is reversibly blocked by inhibitors of DNA synthesis. PMID- 4332913 TI - [On hepatic scintiscanning]. PMID- 4332912 TI - A magnetic resonance study of radical recombination in irradiated cysteine hydrochloride monohydrate. PMID- 4332914 TI - [Intra-operative x-ray therapy of middle-ear carcinoma]. PMID- 4332915 TI - The use of gamma camera in studying cerebral tumours and ischaemic cerebrovascular lesions. PMID- 4332916 TI - [Temperature sensitive mutants of poliomyelitis virus. II. Synthesis of viral protein components under unsettled conditions]. PMID- 4332917 TI - [Human infection by group SV5-DA group para-influenza viruses]. PMID- 4332918 TI - [An immunohistochemical study of the group specific antigen of mouse leukemia viruses]. PMID- 4332919 TI - [Chronic infection of human embryo diploid cells caused by Japanese encephalitis virus]. PMID- 4332920 TI - [Isolation of virus ribonucleoprotein from the nuclei of cells infected with myxoviruses]. PMID- 4332921 TI - [The replicative complexes of Sendai virus]. PMID- 4332922 TI - [Increase in frequency of cell transformation by polyoma virus in vitro with Tween-80]. PMID- 4332923 TI - [Induction of a specific transplantation antigen in cell cultures of syngenous embryonal hamster tissue infected with SV40 virus]. PMID- 4332924 TI - [The interaction of interferon antibodies and leukocytes in experiments in vitro]. PMID- 4332925 TI - [Synthesis of the components of the encephalomyocarditis virus. The RNA of polymerase reaction in vitro]. PMID- 4332926 TI - [The properties of a virus indistinguishable from the agent of smallpox among monkey pox viruses]. PMID- 4332927 TI - [Use of the sorption properties of wide pore glass for chromatographic purification of poliomyelitis virus]. PMID- 4332928 TI - [The antifungal effect of the sodium salt of levorin in cell cultures]. PMID- 4332929 TI - A technique of anaesthesia, especially adapted for ear surgery, "protected sleep". PMID- 4332930 TI - Morphological aspects of the renin-angiotensin system. PMID- 4332931 TI - [Arrhenoblastoma ovarii, report of one case]. PMID- 4332932 TI - Primary cutaneous cryptococcosis: review and morphologic study. PMID- 4332933 TI - [Glucose in the saliva]. PMID- 4332934 TI - Carcinoid and adenoid cystic carcinoma of the bronchus. PMID- 4332935 TI - Cell line derived from a murine sarcoma virus (Moloney Pseudotype)-induced tumor: cultural, antigenic, and virological properties. AB - A cell line derived from a murine sarcoma virus (Moloney pseudotype)-induced tumor has been established. It retains oncogenicity, releases both sarcoma and leukemia viruses, and has virus-induced cellular antigens. PMID- 4332936 TI - Effect of polycations on sensitivity of BALD-3T3 cells to murine leukemia and sarcoma virus infectivity. AB - Polybrene or diethylaminoethyl dextran, when added with murine leukemia or sarcoma virus inocula, significantly increased virus infectivity of BALB/3T3 cells. Residual polycation concentrations were nontoxic. PMID- 4332937 TI - Cytomegalovirus neutralization by plaque reduction. PMID- 4332938 TI - The intracellular development of vesicular stomatitis virus and two of its mutants. PMID- 4332939 TI - Neutralizing capacity of poliovirus type 3 antibodies tested against 5 different intratypic variants of poliovirus type 3. A comparative study in children immunized with live, inactivated, or both types of poliovirus vaccines. PMID- 4332940 TI - Effect of thiothixene on digital computer sleep prints of schizophrenic patients. PMID- 4332941 TI - The secondary structure of replicating polyoma virus DNA. PMID- 4332942 TI - Alterations in the transfer RNA population of hepatoma 9618A as compared with normal rat liver. PMID- 4332943 TI - Studies on the nature of messenger RNA in phytohemagglutinin-stimulated rat lymphocytes. PMID- 4332944 TI - [Protein-phosphokinases from thyroid tissue]. PMID- 4332945 TI - A cyclic AMP binding protein of rat liver; interaction with an histone kinase. PMID- 4332946 TI - [Influence of corticosteroids on the particulate glycogen of fetal liver of the rat]. PMID- 4332947 TI - Mitochondrial DNA from cells transformed by adenoviruses and SV 40. PMID- 4332948 TI - RNA-dependent DNA polymerase in viruses and cells: views on the current state. PMID- 4332949 TI - Purification and some properties of neutral deoxyribonuclease from plaice liver. PMID- 4332950 TI - Incorporation of 14 C-labelled fatty acids into lipids of rhesus erythrocytes and Plasmodium knowlesi in vitro. PMID- 4332952 TI - [Neurography. Contrast-medium roentgenography of the peripheral nerves. Results using a percutaneous method]. PMID- 4332951 TI - Adaptation in oxidative metabolism of Trypanosoma rhodesiense during transformation in culture. PMID- 4332953 TI - [Radiological study on the effect of drugs on lymphatic vessels of the legs. Possibilities of diagnostic use and therapeutic aspects]. PMID- 4332954 TI - [Animal experiment studies on the therapeutic possibilities in lipiodol-ultra fluid lung embolism]. PMID- 4332955 TI - Selective celiac angiography in carcinoma of liver and amebic liver abscess. PMID- 4332956 TI - Primary intracranial tumors in the elderly. PMID- 4332957 TI - [Histochemical studies on the eye of the blowfly Calliphora erythrocephala Meig. I. ATP-ase, acid phosphatase, alkaline phosphatase and glucose-6-phosphatase]. PMID- 4332958 TI - Biochemicl studies on early and late vitamin D-deficiency rickets in Egyptian infants and children. PMID- 4332959 TI - [Myelobulbography and hernia of the cerebellar amygdalae]. PMID- 4332960 TI - [Recent natural or acquired immunity of Senegalese live stock against bovine rinderpest, mucosal disease, infectious rhinotracheitis and respiratory disease due to parainfluenza 3 virus]. PMID- 4332961 TI - [Study of some physiocochemical properties of the Malagasy porcine encephalomyelitis virus]. PMID- 4332962 TI - RNA-directed DNA synthesis. PMID- 4332963 TI - The Furth-Columbia rat Wilms Tumor. PMID- 4332964 TI - Sendai virus RNA synthesis and nucleocapsid formation in the presence of cycloheximide. PMID- 4332965 TI - Accentuation of interferon production by metabolic inhibitors and its dependence on protein synthesis. PMID- 4332966 TI - Cellular DNA replication in infections with cytocidal RNA viruses. PMID- 4332967 TI - Detection and properties of a genomic masked viral particle consisting of foot and-mouth disease virus nucleic acid in bovine enterovirus protein capsid. PMID- 4332968 TI - Early events required for induction of chromosome abnormalities in human cells by herpes simplex virus. PMID- 4332969 TI - Characterization of type 1 poliovirus by electrophoretic analysis. PMID- 4332970 TI - Biogenesis of vaccinia: effect of rifampicin on transcription. PMID- 4332972 TI - Transformation by rous sarcoma virus: effects on cellular glycolipids. PMID- 4332971 TI - The effect of a carbobenzoxy tripeptide on the biological activities of measles virus. PMID- 4332973 TI - Effects of splenectomy on production of endotoxin-type interferon in mice. PMID- 4332974 TI - Proteins of vesicular stomatitis virus. 3. Intracellular synthesis and extracellular appearance of virus-specific proteins. PMID- 4332975 TI - Lipid composition of Sindbis virus. PMID- 4332976 TI - Conditional lethal mutants of avian sarcoma viruses. II. Analysis of the temperature-sensitive lesion in ts 75. PMID- 4332977 TI - Clonal isolation of murine sarcoma virus (MSV): characterization of virus produced from transformed cells. PMID- 4332978 TI - Variation in properties of SV40-transformed simian cell lines detected by superinfection with SV40 and human adenoviruses. PMID- 4332980 TI - Noninfectious AKR mouse embryo cell lines in which each cell has the capacity to be activated to produce infectious murine leukemia virus. PMID- 4332979 TI - Comparison of neuraminidases of paramyxoviruses with immunologically dissimilar hemagglutinins. PMID- 4332981 TI - Induction of avian tumor viruses in normal cells by physical and chemical carcinogens. PMID- 4332982 TI - Spontaneous segregation of nontransforming viruses from cloned sarcoma viruses. PMID- 4332983 TI - Genetically stable reassortment of markers during mixed infection with avian tumor viruses. PMID- 4332984 TI - Differences in thermal stability of deoxythymidine kinase activity in extracts from cell infected with herpes simplex virus type 1 or type 2. PMID- 4332985 TI - SV40-induced DNA synthesis and the fixation of the transformed state. PMID- 4332987 TI - [Clinical picture and results of the surgical treatment of hormonally active tumors of the adrenal cortex in boys]. PMID- 4332986 TI - VP 4, the D-reactive part of poliovirus. PMID- 4332988 TI - [Histochemical characteristics of oxidation-reduction enzymes in epithelial tumors of the urinary bladder]. PMID- 4332989 TI - [Tumor growth following immunization of animals with initially normal tissues]. PMID- 4332990 TI - [A glomus tumor of the external genitalia]. PMID- 4332991 TI - [The necessity of cytogenetic control of tumor strains]. PMID- 4332992 TI - [Etiology and treatment of sleep disorders in adults based on neurophysiological and psychopathological principles]. PMID- 4332993 TI - [Clinical pharmacology of narcotics and sedatives]. PMID- 4332994 TI - [Microtest for the detection of neutralizing antibodies against equine rhinopneumonitis virus]. PMID- 4332995 TI - [Studies on bovine reovirus infections in the Federal Republic of Germany]. PMID- 4332996 TI - A classification of nuclear aberration in relation to malignancy associated changes (MAC). PMID- 4332997 TI - [Case of congenital cytomegaly]. PMID- 4332998 TI - Comparison of performance characteristics of dust respirators made in the United States and the United Kingdom. PMID- 4332999 TI - Effect of intraperitoneal chloramphenicol in some mitochondrial enzymes in neonatal rats. PMID- 4333001 TI - Effect of adenosine triphosphate and some anti-inflammatory agents on a purified lysosomal fraction having high acid phosphatase and labile -glucuronidase activity. PMID- 4333000 TI - Effects of chloroform, diethyl ether and a propiophenone derivative, 3 dimethylamino-2-methyl-2-phenoxypropiophenone hydrochloride, upon cyclic 3',5' nucleotide phosphodiesterase. PMID- 4333002 TI - Different sensitivities of the phosphodiesterases (adenosine-3',5'-cyclic phosphate 3'-phosphohydrolase) of dog cerebral cortex and erythrocytes to inhibition by synthetic agents and cold. PMID- 4333003 TI - [Study of the influence of a reduction of pH on cellular metabolism and development of the poliomyelitis virus]. PMID- 4333005 TI - Bilaterality of breast cancer: biopsy of the contralateral breast. PMID- 4333004 TI - Hepatitis-associated antigen in sporadic cases of acute viral hepatitis. AB - Serum specimens collected during the period from September 1970 to April 1971 from hospitalized patients and apparently healthy staff members at risk were tested for the presence of hepatitis-associated antigen (HAA) by the parallel use of three techniques: the complement fixation test, crossover-electrophoresis and immuno-electronmicroscopy.Out of a total of 204 persons investigated 63 (30.9%) were found to harbour the antigen. The HAA-positive sera originated almost exclusively from sporadic cases of acute viral hepatitis (clinically diagnosed as "infectious hepatitis" or "serum hepatitis"). The great majority of the hepatitis cases studied had a history of drug addiction. PMID- 4333006 TI - Influence of neonatal thymectomy upon the cell-mediated tumor-specific immunity in Rous sarcoma virus tumorigenesis in rats. PMID- 4333007 TI - Autologous and allogeneic stimulation of peripheral human leukocytes. PMID- 4333008 TI - Dual effects of iodide IV on reduced pyridine nucleotides in rabbit thyroid in situ: iodide induces oxidation and prevents oxidative response to thyrotropin. PMID- 4333009 TI - Effect of adrenal and hypophyseal hormones on the development of fatty liver in rats fed orotic acid. PMID- 4333011 TI - Preliminary characterization of the pituitary melanocyte stimulating hormones of several vertebrate species. PMID- 4333010 TI - Guanosine 3'5' cyclic monophosphate is a potent pituitary growth hormone secretogogue. PMID- 4333012 TI - Simultaneous radioimmunoassay for the measurement of adenosine 3',5' monophosphate and guanosine 3',5'-monophosphate. PMID- 4333014 TI - Anti-lipolytic action of tolbutamide on brown fat cells. PMID- 4333013 TI - The effect of tolbutamide on lipolysis and cyclic AMP concentration in white fat cells. PMID- 4333015 TI - Cholesterol ester concentration and corticosterone production in adrenals of the C57BL-10 and DBA-2 strains in relation to adrenal lipid depletion. PMID- 4333016 TI - [Effect of angiotensin II on arterial blood pressure, glomerular filtration rate and urinary sodium excretion in healthy rats, pregnant rats and rats with arterial hypertension]. PMID- 4333017 TI - Viral-induced ocular tumors in chicks. PMID- 4333018 TI - Loss of the cholesterol feedback system in the intact hepatoma-bearing rat. AB - By means of the desmosterol suppression technique described in the previous paper, the influence of hepatomas on sterol metabolism has been studied in the intact rat. The major finding of this study is that all hepatoma-bearing rats demonstrate a consistent in vivo loss of the cholesterol feedback system that is characteristic of normal liver. The results also demonstrate that such tumors retain only minor amounts of the sterol they synthesize, releasing over 90% of such endogenous sterol into the circulation. Finally, the in vivo loss of cholesterol feedback control was found to occur in at least two minimal deviation hepatomas and in one highly malignant adenocarcinoma of hepatic origin. These findings indicate that even tumors that are capable of only very limited cholesterol synthesis in vitro, can contribute significant quantities of sterol to the bloodstream. It is concluded that as a result of their lack of normal cholesterol feedback control, hepatomas may represent a physiologically important source of sterols in the tumor-bearing animal, and that the absence of feedback control of sterol synthesis may provide a means of detecting the presence of such tumors in the intact animal. PMID- 4333020 TI - Effects of elastase, collagenase, and papain on structure and function of rat lungs in vitro. AB - Present concepts of the roles of collagen and elastin in lung elastic behavior and maintenance of lung structure have been largely inferred from anatomical observations or from studies of isolated fibers in vitro. Based on the intimate association of elastin and collagen it has been postulated that elastin contributes little to elastic behavior and that collagen is the major determinant of lung structure. Using clostridial collagenase, pancreatic elastase, and papain we have selectively degraded these fibers and studied the resulting changes in elastic behavior and structure of rat lungs in vitro.Pressure-volume curves were recorded during continuous slow air inflation and deflation (10.5 ml/min) before and after the intratracheal instillation of 0.5 ml of control or enzyme solution. Surface tension-lowering activity of lavaged material was studied. All lungs were fixed inflated at 25 cm H(2)O pressure and whole lung sections were stained for elastin, collagen, and reticulin. Collagenase produced a marked susceptibility to pleural rupture but did not alter elastic behavior or lung structure. Elastase and papain produced segments of lung with increased compliance; this change was not due to alteration in surface forces but was associated with decreased tissue elastic recoil. Histologically, altered tissue recoil correlated well with evidence of damaged elastin fibers. In contrast to previous concepts these results suggest that elastin is the major connective tissue determinant of lung structure and elastic behavior. PMID- 4333019 TI - The stimulus-secretion coupling of glucose-induced insulin release. VII. A proposed site of action for adenosine-3',5'-cyclic monophosphate. AB - Glucose-induced insulin release is thought to result from the following sequence of events in the beta cell: glucose metabolism leading to the production of a metabolic signal, net calcium uptake by the beta cell in response to the signal, and interaction between calcium and a microtubular-microfilamentous system, leading to emiocytosis of the secretory granules. Dibutyryl-cyclic AMP (db-cAMP) and theophylline are known to potentiate glucose-induced insulin release, their insulinotropic action being most marked at high glucose concentrations. Based on the above mentioned concepts, it was considered in the present experiments that the primary site of action of cAMP in the beta cell could correspond to either a facilitation of glucose metabolism, a modification of calcium distribution, or an interaction with the microtubular-microfilamentous system. The first of these hypotheses appeared unlikely because db-cAMP and theophylline, in sharp contrast with other agents known to affect glucose metabolism in the beta cell, did not modify glucose-induced calcium uptake by isolated islets incubated at high glucose concentrations. The last hypothesis also appeared unlikely since theophylline did not interfere with the deleterious effect of colchicine on the microtubular system, and since vincristine or colchicine did not differentially affect the respective insulinotropic action of glucose and theophylline. An effect of cAMP upon calcium distribution in the beta cell was suggested by the following findings. Whereas glucose and leucine were unable to promote insulin release in the absence of extracellular calcium, the addition of db-cAMP or theophylline to the calcium-depleted media partially restored theinsulinotropic action of glucose and leucine. Moreover, theophylline caused a dramatic increase in (45)Ca efflux from perifused islets, even in the absence of glucose. It is concluded that the insulinotropic action of cAMP could be due to a glucose independent translocation of calcium within the beta cell, from an organelle bound pool to a cytoplasmic pool of ionized calcium readily available for transport across the cell membrane. PMID- 4333021 TI - Coagulant activity of leukocytes. Tissue factor activity. AB - Peritoneal leukocytes harvested from rabbits which have received two spaced doses of endotoxin have significantly greater (10-fold) coagulant activity than leukocytes from control rabbits. The coagulant activity accelerates the clotting of normal plasma and activates factor X in the presence of factor VII and calcium and is therefore regarded as tissue factor. A total of 40-80 mg tissue factor activity was obtained from the peritoneal cavity of single endotoxin-treated rabbits. In leukocyte subcellular fractions, separated by centrifugation, the specific tissue factor activity sedimented mainly at 14,500 g and above. The procoagulant activity was destroyed after heating for 10 min at 65 degrees C but was preserved at lower temperatures. Polymyxin B, when given with the first dose of endotoxin, reduced both the number of peritoneal leukocytes and their tissue factor activity by two-thirds. When given immediately before the second dose of endotoxin, polymyxin B had no inhibitory effect. PMID- 4333023 TI - The actin and myosin filaments of human and bovine blood platelets. AB - The contractility of platelets has been attributed to an actomyosin-like protein which has been well defined on a physicochemical basis. Moreover, platelets contain +/-80 A filaments which resemble actin filaments in smooth muscle. Studies were undertaken on human and bovine platelets to better define the morphologic structures which may subserve this contractile function. In order to identify actin, the ability of the filaments to react with heavy meromyosin (HMM) was tested. Accordingly, platelets were glycerinated and treated with HMM. In addition, platelet actin was extracted, reacted with HMM, and examined by negative staining. In both instances typical arrowhead structures with clearly defined polarity and a periodicity of +/-360 A formed. As is the case with purified muscle actin, the complexes were dissociable with Mg-ATP. The formation of myosin-like filaments was observed when osmotically shocked platelets were incubated with MgCl(2) and excess ATP. These "thick" filaments measured 250-300 A in width, tapered at both ends and often occurred in clumps. They resembled aggregates of thick filaments described in contracted smooth muscle. Extraction of platelets by methods suitable for the demonstration of myosin showed filaments with an average length of 0.3 mu, a smooth shaft, and frayed or bulbous ends. These appeared identical to those seen in synthetically prepared myosin of striated muscle. It is suggested that the filaments described here represent the actin and myosin of platelets. PMID- 4333022 TI - Evidence for a direct action of cholecalciferol and 25-hydroxycholecalciferol on the renal transport of phosphate, sodium, and calcium. AB - Acute clearance studies were performed in stable thyroparathyroidectomized dogs to evaluate the possibility of a direct renal action of vitamin D and its biologically active 25-hydroxylated metabolite. Alterations in renal hemodynamics and serum calcium concentration were minimized and attempts at vitamin D depletion were not undertaken. Steady-state volume expansion of modest degree was employed as the control experimental situation so that an effect of the vitamin to enhance phosphate reabsorption would not go undetected because of an already maximal phosphate reabsorptive rate secondary to parathyroidectomy. Under these experimental circumstances, 10,000 U of cholecalciferol and 25-120 U of 25 hydroxycholecalciferol (25-HCC) produced significant depressions in the percentage of filtered phosphate excreted (mean declines of 39 and 47%, respectively), which were not attributable to alterations in renal hemodynamics or to changes in the levels of serum calcium or phosphate. There was an accompanying decline in sodium and calcium excretion; mean percentage excretion rates for sodium fell by 38% with vitamin D and 26% with 25HCC, and for calcium this measurement declined by 46 and 23%, respectively. Furthermore, parathyroid hormone and 25HCC produced antagonistic effects on phosphate excretion. These observations provide the first conclusive evidence for a direct (proximal) tubular action of vitamin D to promote phosphate (as well as sodium and calcium) transport. PMID- 4333024 TI - Prostaglandins and their effects on human placental adenyl cyclase. AB - Prostaglandins increased adenyl cyclase activity in human term placental homogenates in a dose-dependent manner during 10-min incubation periods. The potency of the prostaglandins examined was demonstrated to be in the ascending order, prostaglandin F(1alpha) < A(2), F(2alpha), B(2) < A(1) < E(2) < E(1). Although no specific trophic or regulating factors for placental function have been described as yet, it is possible that prostaglandins which are synthesized in decidual tissue could play such a physiological role. PMID- 4333025 TI - Blockade of adrenergic vasoconstrictor responses in the dog by prostaglandins E 1 and A 1 . PMID- 4333026 TI - Enhancement of coronary vasodilator action of nicotinamide adenine dinucleotide by lidoflazine. PMID- 4333027 TI - [Recent advances in early diagnosis of the damage of the peripheral nerve fibers in industrial medicine]. PMID- 4333028 TI - [Surgical treatment of pituitary adenoma]. PMID- 4333029 TI - An in vitro study of biomechanical changes produced by hypermetabolism and hypometabolism in skeletal muscle. PMID- 4333030 TI - Histometric study of neuromuscular junction ultrastructure. I. Myasthenia gravis. PMID- 4333031 TI - Peripheral neuropathy with myokymia, sustained muscular contraction, and continuous motor unit activity. PMID- 4333032 TI - Specific involvement of muscle, nerve, and skin in late infantile and juvenile amaurotic idiocy. PMID- 4333033 TI - Cerebral spongy degeneration of infancy. A biochemical and ultrastructural study of affected twins. PMID- 4333035 TI - Rickets, American style. PMID- 4333034 TI - [Glucagon--a therapeutic alternative in heart failure?]. PMID- 4333036 TI - An activity from mammalian cells that untwists superhelical DNA--a possible swivel for DNA replication (polyoma-ethidium bromide-mouse-embryo cells-dye binding assay). AB - Nuclei from secondary mouse-embryo cells contain an activity capable of untwisting closed-circular DNAs containing either negative or positive superhelical turns. The activity has no apparent effect on a closed-circular DNA containing no superhelical turns, and is not due to the combined action of an endonuclease and polynucleotide ligase. The enzyme apparently acts by introducing a single-strand nick into the DNA, forming a DNA-enzyme complex that allows the strands to rotate relative to the helix axis before reversing the reaction and sealing the break. The enzyme might possibly serve as a swivel during DNA replication. PMID- 4333037 TI - Binding of -bungarotoxin to acetylcholine receptors in mammalian muscle (snake venom-denervated muscle-neonatal muscle-rat diaphragm-SDS-polyacrylamide gel electrophoresis). AB - Experiments were performed to determine the specificity of [(125)I]alpha bungarotoxin binding to skeletal muscle. In adult rat diaphragm, [(125)I]alpha bungarotoxin was found to bind almost exclusively to those regions of the muscle that contain endplates and are known to be sensitive to acetylcholine. In contrast, chronically denervated adult muscle and muscle from neonatal rats, both of which are sensitive along their entire lengths, bound substantial amounts of toxin in all regions. Toxin binding to all muscles was inhibited by d tubocurarine and by carbamylcholine, but not by atropine. The bound [(125)I]toxin was solubilized by homogenization of the tissue in 1% Triton X-100 and was recovered as a single band, distinct from free toxin, after zone sedimentation. Treatment of the solubilized, toxin-bound complex with 2-mercaptoethanol and sodium dodecyl sulfate resulted in the recovery of free toxin. A toxin-bound complex was also obtained when toxin was incubated directly with extracts of muscle endplate regions prepared by homogenization in Triton X-100. No such complex was observed with extracts prepared from muscle lacking endplates. These results are consistent with the interpretation that alpha-bungarotoxin binds specifically to the acetylcholine receptor of mammalian skeletal muscle. PMID- 4333038 TI - Detection and quantitation of simian virus 40 genetic material in abortively transformed BALB-3T3 clones (mice-diploid cells-virus equivalents). AB - Infection with simian virus 40 is known to induce many cells to synthesize DNA and to divide in a medium lacking serum protein growth factor(s) that is essential for growth of uninfected cells (factor-free medium). Cells infected under these conditions then go through several rounds of division, since colonies containing more than 100 cells are formed. Many of these colonies are abortively transformed since, upon subsequent passage of the cells in standard medium, they can no longer grow in factor-free medium and show no other properties of viral transformation. We have examined these abortively transformed cells for the presence of simian virus 40 DNA sequences. Of the three clones tested, two were found to contain viral genetic material despite the fact that they were phenotypically normal. The number of simian virus 40 genome equivalents present was determined by measurement of DNA reassociation kinetics on hydroxyapatite. Two of the abortively transformed lines contained approximately five viral genome equivalents per diploid cell, while the DNA from a third abortive transformant was indistinguishable from that of uninfected BALB/3T3 cells. A standard simian virus 40 transformant, isolated under similar conditions, contained two copies of the viral genome per cell. The abortive transformants also appear to contain the entire viral genome rather than multiple partial copies. Subclones of one abortively transformed line containing five copies per cell had 2.7-10 copies of viral genetic material per diploid cell. PMID- 4333039 TI - Detection of avian tumor virus-specific nucleotide sequences in avian cell DNAs (reassociation kinetics-RNA tumor viruses-gas antigen-Rous sarcoma virus, chick cells). AB - The effect of unlabeled cellular DNA upon the reassociation kinetics of labeled double-stranded DNA made by DNA polymerase from avian tumor viruses has been used to measure virus-specific nucleotide sequences in cells. Multiple copies of these sequences were found equally in normal chick cells, in chick cells transformed in culture, and in Rous tumor cells. Copies were also present equally in cells harboring chick helper factor and group-specific antigen, and in cells lacking those characteristics. Quail DNA also contains multiple copies of these sequences, but no copies were detected in HeLa-cell DNA or salmon-sperm DNA. PMID- 4333040 TI - Some structural and antigenic properties of intracisternal A particles occurring in mouse tumors (complement fixation-immunodiffusion-neuroblastoma-plasma-cell tumor). AB - Intracisternal A-particles were isolated from three different myeloma lines in BALB/c mice and from cultured neuroblastoma cells of A/J origin. All preparations contained a major structural protein with an apparent molecular weight near 70,000 as estimated by electrophoretic mobility in sodium dodecyl sulfate containing polyacrylamide gels. Solubilization of this component by sodium dodecyl sulfate was dependent on prior or concomitant treatment with sulfhydryl compounds. The size distribution of A-particle proteins was markedly different from that observed for extracellular murine leukemia and mammary tumor viruses. Rabbit antiserum was developed that reacted with the major A-particle protein in both complement fixation and immunodiffusion assays. The antigen was detected in isolated neuroblastoma A-particles, in cytoplasmic membrane fractions prepared from various mouse tumors known to contain intracisternal particles, but not in preparations from normal mouse cells, in samples of leukemia and mammary tumor virus, or in JLS-V9 cells infected with Rauscher leukemia virus. Conversely, isolated A-particles did not react in complement fixation or immunodiffusion assays with antisera against leukemia virus antigens. PMID- 4333041 TI - Teichoic acid hydrolase activity in soil bacteria (Bacillus subtilis-sporulation phosphodiesterase-polyamines-concanavalin A). AB - Bacterial phosphodiesterases have been found that are capable of cleaving the backbone of teichoic acid. Such enzymes have not been reported previously. An aerobic, gram-negative, rod-shaped bacterium producing this activity was detected and isolated by autoradiography of soil suspensions growing on minimal medium containing (32)P-labeled Bacillus subtilis ATCC 6051 cell walls as the sole phosphorus source. Broken-cell preparations are capable of depolymerizing teichoic acids in media of low ionic strength at near-neutral pH values. An active teichoicase is also present in B. subtilis, ATCC 6051 (the Marburg strain), especially in sporulating cultures. PMID- 4333042 TI - Potassium: effect on DNA synthesis and multiplication of baby-hamster kidney cells: (cell cycle-membrane potential-synchronization-transformation). AB - The relations between DNA synthesis, cell multiplication, and external potassium concentration have been investigated in cultured baby-hamster kidney cells. When the potassium concentration was raised from 8 mM to 114 mM by equimolar replacement of sodium, DNA synthesis and cell multiplication were almost completely inhibited. This inhibition was reversible even after 72 hr of incubation in medium with a high concentration of potassium. There is a consistent difference between the cultured cells and polyoma virus-transformed cells in response to high-potassium medium, a higher-potassium concentration being required to inhibit multiplication of polyoma virus-transformed cells to the same extent as that of the nontransformed cells. PMID- 4333043 TI - In vitro synthesis of DNA complementary to purified rabbit globin mRNA (RNA dependent DNA polymerase-reticulocyte-hemoglobin-density gradient centrifugation oligo(dT) primer). AB - Several properties of the viral RNA-dependent DNA polymerases and of rabbit globin mRNA make it possible to consider synthesis of the globin gene in vitro. These enzymes copy an RNA template using a short sequence of complementary nucleotides as a primer. Furthermore, globin mRNA has a 3'-terminal sequence of adenylic acid residues that make it particularly suitable as a template, since oligo(dT) can be annealed to a specific site on the mRNA. This small primer could phase the DNA polymerase, possibly ensuring that replication is initiated from that end of the globin message. We have used this approach and find that purified mRNA is an efficient template for the polymerase enzyme. The reaction requires the RNA template and the four deoxyribonucleoside triphosphates, and it is markedly stimulated by the addition of oligo(dT). Consistent with the expectation that the oligo(dT) uniquely phases the polymerase at an adenine-rich region in the globin message, oligo(dG), oligo(dC), and oligo(dA) fail to serve as primers. The product has a density intermediate between that of DNA and RNA, and shifts to a lighter DNA density after treatment with base. Further, it is specifically complementary to globin mRNA and sediments slightly faster in an alkaline sucrose gradient than a DNA standard that has a molecular weight of 129,000. The data suggest that a major portion of the DNA product is a sequence of at least 500 bases, about 50 more than would be necessary to encode rabbit globin. The potential usefulness of this interesting product is discussed. PMID- 4333044 TI - Prostaglandin E 1 effects on adenosine 3':5'-cyclic monophosphate concentration and phosphodiesterase activity in fibroblasts (mouse L cells-tissue culture enzyme kinetics-prostaglandin homologues). AB - Incubation of L-929 and L-2071 fibroblasts with prostaglandin E(1) (PGE(1)) caused a rapid increase in the cyclic AMP content of these cells. A maximal effect was produced with 0.2 mug PGE(1) per ml. At a concentration of 4 mug/ml, PGE(2) was almost equally effective, but PGF(2alpha) and PGA(2) were much less so. 2.6 muM epinephrine, 0.4 mM serotonin, and 0.2% ethanol were without effect. In L-929 cells, cyclic AMP concentrations remained elevated for 2-5 hr, and then declined, although even after a 24-hr incubation the medium contained PGE(1) in a concentration sufficient to increase maximally the cyclic AMP content of cells not previously exposed to this compound. A second addition of PGE(1) after 5 or 24 hr did not produce another increase in the concentration of cyclic AMP. After incubation with PGE(1) for 24 hr, cyclic AMP phosphodiesterase activity, assayed with 0.56 muM substrate, was increased 30-100%; the activity rose further between 24 and 48 hr. It is suggested that the increase in phosphodiesterase activity that appears to be a consequence of prolonged elevation of cyclic AMP concentration may account at least in part for the apparent "refractoriness" to PGE(1) that develops after incubation for several hours with this compound. PMID- 4333045 TI - Physical mechanisms in photosynthesis: past elucidations and current problems. PMID- 4333047 TI - Growth inhibition of sympathetic cells by some adrenergic blocking agents (6 hydroxydopamine-mice and rats-immunosympathectomy-chemical sympathectomy-superior cervical ganglion). AB - Treatment of newborn mice and rats with the adrenergic blocking agents, guanethidine and bretylium tosylate, results in massive destruction of immature sympathetic nerve cells. A growth inhibition of the same cells is caused by reserpine. Similarities and differences between the effects elicited by these three ganglion blocking agents and a dopamine analog, 6-hydroxydopamine, are discussed. PMID- 4333046 TI - A transport form of collagen from embryonic tendon: electron microscopic demonstration of an NH 2 -terminal extension and evidence suggesting the presence of cystine in the molecule (chick embryo-tropocollagen-gel filtration). AB - When cells were isolated from chickembryo tendons and incubated in vitro for 2-6 hr, essentially all the newly-synthesized collagen was recovered from the incubation medium as a transport form larger than tropocollagen. Experiments in which cells were incubated with [(14)C]cystine suggested that the transport form contained cystine and that it was, in part, stabilized by disulfide bonds. Electron microscopy of segment-long-spacing aggregates prepared from the transport form of collagen showed that the native molecule differed from tropocollagen in that it had an extension of about 13 nm (130 A) at the NH(2) terminal end. PMID- 4333048 TI - [Deoxythimidine kinase]. PMID- 4333049 TI - Unpaired electrons in 365 nm irradiated fibrous proteins. PMID- 4333050 TI - The kinetics of radical decay in crystalline amino acids. PMID- 4333051 TI - Electron spin resonance study of radicals produced in irradiated aqueous solutions of uracil and related pyrimidines. PMID- 4333053 TI - [Neurological changes in rheumatoid arthritis in children]. PMID- 4333052 TI - Transient radicals of DNA bases by pulse radiolysis. Effects of cysteine and cysteamine as radioprotectors. PMID- 4333054 TI - [Hypothalamic insufficiency in pregnancy: an indication for synthetic A.C.T.H. treatment]. PMID- 4333056 TI - [Amylosis with clinically prevalent intestinal localization, revealing Hodgkin's disease]. PMID- 4333055 TI - [Chronic pancreatitis, diabetes mellitus and specific microangiopathy]. PMID- 4333057 TI - [Tetanu. 254 cases]. PMID- 4333058 TI - [Migraines due to tyramine]. PMID- 4333059 TI - [The hospital and the hospital revolution]. PMID- 4333060 TI - [Problems of cerebral death]. PMID- 4333061 TI - [Studies on the reactive mechanism of orthophosphate in urinary calculi ailment]. PMID- 4333063 TI - [Histoenzymology of the normal and pathologic small intestine]. PMID- 4333064 TI - Biological aspects of gestational neoplasms derived from trophoblast. PMID- 4333065 TI - The pathology of choriocarcinoma. PMID- 4333066 TI - [Increase and modification of the carcinogenic power of mammary tumors virus, after treatment with ethylene oxide; distribution of viral particles]. PMID- 4333062 TI - [The biological role of cyclic AMP]. PMID- 4333068 TI - [Interaction of descending effects caused by motor cortex stimulation and some spinal cord conducting pathways]. PMID- 4333067 TI - [Liver and hepatoma carnosine-anserine-synthetase]. PMID- 4333069 TI - [Biopsy of salivary glands]. PMID- 4333070 TI - Evaluation of asbestos exposures in the working environment. PMID- 4333071 TI - Interaction between thyrotrophin, corticotrophin and growth hormone secretion in man. PMID- 4333072 TI - The role of the medial forebrain bundle in mediating adrenocortical responses to neurogenic stimuli. PMID- 4333073 TI - Bioassay of oxytocin by changes in light penetration through rat mammary gland tissue in vitro. PMID- 4333074 TI - Some characteristics of nocturnal penile tumescence in elderly males. PMID- 4333075 TI - Regenerating capillary basement membrane in skeletal muscle wounds. Ultrastructural and histochemical study. PMID- 4333076 TI - Congenital dyserythropoietic anemia type II. Ultrastructure of erythroid cells and hepatocytes. PMID- 4333077 TI - Neurosecretory appearing cells of human segmental bronchi. PMID- 4333079 TI - A stereologic study of the effects of ACTH and cyclic 3',5'-AMP on adrenocortical cells of intact and hypophysectomized rats. PMID- 4333078 TI - A unique rough surfaced endoplasmic reticulum inclusion in pseudoachondroplasia. PMID- 4333080 TI - The induction of tumors of the nervous system with intravenous methylnitrosourea. PMID- 4333081 TI - Endoplasmic reticulum, lipid, and glycogen of Morris hepatomas. Comparison with alterations in hepatocytes. PMID- 4333082 TI - Isolation of virus related to SV40 from patients with progressive multifocal leukoencephalopathy. PMID- 4333083 TI - Detection of heterozygote in Lesch-Nyhan disease by hair-root analysis. PMID- 4333084 TI - Viruses and progressive multifocal leukoencephalopathy. PMID- 4333085 TI - [Morphological changes in the central nervous system in the course of Creutzfeld Jakob disease]. PMID- 4333086 TI - Neuronal coding of motivational level during sleep. PMID- 4333087 TI - [Blood ACTH levels in Itsenko-Cushing's disease]. PMID- 4333088 TI - [Role of adrenoreactive and M-cholinoreactive structures of the central nervous system in the development of compensatory hypertrophy of the adrenal glands]. PMID- 4333090 TI - [Blood coagulation in dogs following a 1st and second injection of adrenocorticotropin]. PMID- 4333089 TI - [Reaction of hypophyseal-adrenal system of the rat fetus to stress]. PMID- 4333091 TI - Differences in the quantitative distribution of lysine-rich histones in neoplastic and normal tissues. PMID- 4333092 TI - Effect of poly I:C on infectious bovine rhinotracheitis virus infection in calves. PMID- 4333093 TI - Activities in vitro of 8-substituted derivatives of adenosine-3',5'-cyclic monophosphate on guinea pig trachea and rat portal vein. PMID- 4333094 TI - Interferon and cell division. V. Titration of the anticellular action of interferon preparations. PMID- 4333095 TI - Stimulation of erythropoiesis in the plethoric mouse by cyclic-AMP and its inhibition by antierythropoietin. PMID- 4333096 TI - Effects of angiotensin infusion on the isolated rabbit kidney. PMID- 4333097 TI - Type 12 adenovirus proteins: influence on tumor development in offspring of immunized pregnant hamsters. PMID- 4333098 TI - Activity of mouse interferon in human cells. PMID- 4333099 TI - Role of renin in the regulation of angiotensinogen levels in plasma. PMID- 4333101 TI - Establishment of cell lines from normal adult human blood leukocytes by exposure to Epstein-Barr virus and neutralization by human sera with Epstein-Barr virus antibody. PMID- 4333100 TI - Inhibition of adenovirus type 2 by human and monkey interferon. PMID- 4333102 TI - [Considerations on presynaptic neuromuscular transmission and block]. PMID- 4333103 TI - [Site of action of muscle relaxants. Aspects of the transmission at the level of the neuromuscular junction]. PMID- 4333104 TI - [A new case of myxedema due to iodine]. PMID- 4333105 TI - [Early uremic polyneuropathy: clinical and electromyographic study of subjects with and without treatment with extracorporeal dialysis]. PMID- 4333106 TI - [Value of diagnostic tests in pituitary dwarfism. 2. ACTH secretion]. PMID- 4333107 TI - Studies on synaptic transmission using drugs as tools. PMID- 4333108 TI - Psychoactive drugs and sleep: withdrawal rebound phenomena. PMID- 4333109 TI - [Repeated surgery in continued growth of intracerebral neuroectodermal brain neoplasms]. PMID- 4333110 TI - [Liver tumor induction by benzidine in mice]. PMID- 4333111 TI - [Experimental findings concerning the antineoplastic drug fluordopan]. PMID- 4333112 TI - [Transformation of mammalian cells by chemical carcinogens in vitro]. PMID- 4333113 TI - [Circular lesions of the stomach in cancer]. PMID- 4333114 TI - [Detection of tumor cells in the blood of patients with malignant tumors of the rectum]. PMID- 4333115 TI - [Influence of methylprednisolone on the renin-angiotensin-system in endotoxin and orthostatic shock in the rabbit]. PMID- 4333116 TI - [Results of the use of kelocyanor in hydrocyanic acid poisoning]. PMID- 4333118 TI - [Analysis of changes in postsynaptic potentials in a cellular analog of a conditioned reflex]. PMID- 4333117 TI - [The interaction of evoked and background activity in a neuron model without return to zero]. PMID- 4333119 TI - [Dysgammaglobulinemia in postperfusion syndrome]. PMID- 4333120 TI - Myeloperoxidase and crystalline bodies in the granules of DMBA-induced rat chloroma cells. AB - Chloroma (chloroleukemia) was induced in a splenectomized rat by repeatedly administering dimethylbenz(a)anthracene (DMBA) and was serially transplanted thereafter. Composed of immature myeloid cells, the tumor imparted a green discoloration to the tissues that it infiltrated extensively. Chloroma cells fluoresced red in ultraviolet light, produced a characteristic curve in spectrophotometry, and contained large amounts of myeloperoxidase. They included numerous intracytoplasmic granules of both types A and B, which contained occasional crystalline bars. Permanent lines of chloroma cells were established in tissue culture. These cells, while maintaining their initial morphology, ceased producing myeloperoxidase and subsequently induced white tumors when they were isotransplanted. PMID- 4333122 TI - Fluorometric determination of demethylchlortetracycline and tetracycline in mammalian bone. PMID- 4333121 TI - Light and electron microscopy of diet-induced atrial thrombosis in Swiss mice. II. Recovery on return to a balanced diet. AB - Diet-induced ultrastructural changes that occur in the atrial wall prior to thrombus formation are atrial subendothelial edema, endothelial vacuoles, damaged basement membrane and villous projections from endothelial (luminal surface) cells. Upon the return to a normal diet for 1-4 weeks, atrial edema is completely reversible, while the other ultrastructural alterations show minor or no signs of being repaired. PMID- 4333123 TI - Rapid microassay of adenosine 3',5'-monophosphate phosphodiesterase activity. PMID- 4333124 TI - Quantitative extraction and estimation of intracellular nucleoside triphosphates of Escherichia coli. PMID- 4333125 TI - [Interferon and protection of mice against experimental infestation transmitted by the blood forms of Plasmodium berghei injected in massive doses. I. Methods of protection with a viral inducer of interferon]. PMID- 4333128 TI - [Effect of lithium on plasma renin and the pressor responsiveness to angiotensin in man]. PMID- 4333129 TI - [Antibiotic effect of Ciclacillin-Rifampicin combination]. PMID- 4333130 TI - [Macromolecular virostatic substances and their interferon inducing activity]. PMID- 4333131 TI - [Differential diagnosis and therapy of gout and pseudo-gout]. PMID- 4333132 TI - [Penetration by mature particles of mammary cancer virus in producing cells, in vivo]. PMID- 4333133 TI - Role of prostaglandin in thyrotropin action on thyroid. PMID- 4333134 TI - A comparative study of the effects of thyroid stimulating hormone and 2 mercaptoethylamine on glucose oxidation and cyclic AMP levels in thyroid tissue slices. PMID- 4333135 TI - A comparison of the effects of ACTH, cyclic AMP, Dibutyryl cyclic AMP, and PGE2 on corticosteroidogenesis in vitro. PMID- 4333136 TI - Role of the renin-angiotensin system in the vasopressin response to hemorrhage. PMID- 4333138 TI - Evidence for the release of MSH by phenothiazine ataraxics. PMID- 4333137 TI - The importance of stimulus intensity and duration of steroid administration in suppression of stress-induced ACTH secretion. PMID- 4333139 TI - Conditions for the reliable use of lesioned rats for the assay of CRF in tissue extracts. PMID- 4333140 TI - The effect of ACTH priming on pituitary and adrenal function in hypophysectomized rats with ectopic pituitary grafts. PMID- 4333141 TI - Selectively blocked and des-histidine-glucagons: preparation and effects on hepatic adenylate cyclase activity. PMID- 4333142 TI - The response of intestinal calcium transport to 25-hydroxy and 1,25-dihydroxy vitamin D in nephrectomized rats. PMID- 4333143 TI - In vitro effect of hypothalamic extract and other stimulating agents on glucose oxidation and luteinizing hormone (LH) release from rat anterior pituitary glands. PMID- 4333144 TI - Growth hormone and ACTH secretion: evidence for an inverse relationship in rats. PMID- 4333145 TI - Induction of bone resorption in tissue culture. Prolonged response after brief exposure to parathyroid hormone or 25-hydroxycholecalciferol. PMID- 4333146 TI - Escape from inhibition or resorption in cultures of fetal bone treated with calcitoninand parathyroid hromone. PMID- 4333147 TI - Effect of ACTH and aminoglutethimide on cholesterol metabolism in sheep adrenal cortex in vitro. PMID- 4333148 TI - Effect of ACTH on cholesterol dynamics in rat adrenal tissue. PMID- 4333150 TI - Schistosoma mansoni and Haematoloechus medioplexus: nuclosidediphosphatase localization in tegument. PMID- 4333149 TI - Thyrotrophin-induced aggregation and reorganization into follicles of isolated porcine-thyroid cells. 1. Mechanism of action of thyrotrophin and metabolic properties. PMID- 4333151 TI - [Superselective visceral arteriography]. PMID- 4333153 TI - Effect of cytochrome c on succinate oxidation in rat liver mitochondria. PMID- 4333152 TI - A method for the continuous cultivation of mammary epithelium. PMID- 4333154 TI - Cell to cell transfer of RNA into transformed cells. PMID- 4333155 TI - Isolation of inclusion bodies from rabbit lung parenchyma. PMID- 4333156 TI - Lipid components of sarcotubular membranes. PMID- 4333157 TI - [Ultrastructural basis for one type of block of ectopic excitation in the myocardium]. PMID- 4333158 TI - [Fundamental response processes of the respiratory tract towards noxae. B. Alveolar macrophages and noxae]. PMID- 4333159 TI - [Clinical aspects of internal carotid thrombosis]. PMID- 4333160 TI - Effect of corticotropin on ascorbic acid metabolism in rats. PMID- 4333161 TI - Cyclic AMP-stimulated protein kinase prepared from bovine thyroid glands. PMID- 4333162 TI - Activation of adenyl cyclase in a pancreatic islet cell adenoma by glucagon and tolbutamide. PMID- 4333163 TI - Inhibition of cyclic 3',5'-AMP phosphodiesterase in islet cells and other tissues by tolbutamide. PMID- 4333164 TI - Unique high affinity uptake systems for glycine, glutamic and aspartic acids in central nervous tissue of the rat. PMID- 4333165 TI - NAD in the metabolism of motile spermatozoa. PMID- 4333166 TI - [Surgical treatment of injuries to peripheral nervous system]. PMID- 4333167 TI - [Endocrine sequelae of surgically treated craniopharyngioma in children. Study of 7 recent cases]. PMID- 4333169 TI - Ultrathin carbon support films for electron microscopy. AB - Carbon support films only 4 to 6 angstroms thick have been made for use in electron microscopy. The determination of their thickness is based on geometrical calculation, electron scattering measurements, and elemental microanalysis. PMID- 4333168 TI - Studies on the conditions for cyclic AMP formation in homogenised and intact fat cells by use of 3 H-ATP and 3 H-adenine. PMID- 4333170 TI - Phosphodiesterase in Dictyostelium discoideum and the chemotactic response to cyclic adenosine monophosphate. AB - A phosphodiesterase with a low Michaelis constant for cyclic adenosine monophosphate was found in the membrane fraction of the cellular slime mold. This activity was highest during the aggregation stage. Enzyme with similar properties was also secreted by the cells. Dithiothreitol inhibited both enzymes and potentiated the cellular response to cyclic adenosine monophosphate. PMID- 4333171 TI - Cyclic nucleotide phosphodiesterase in Dictyostelium discoideum: interconversion of two enzyme forms. AB - An extracellular cyclic nucleotide phosphodiesterase was isolated from either growing cultures or aggregating amoebas of Dictyostelium discoideum. The enzyme is released in a form with a low Michaelis constant (15 micromolar) and spontaneously undergoes a slow conversion to a less active form with a high Michaelis constant (2 mnillimolar). Inactivation was prevented or reversed by use of Cleland's reagent, dithiothreitol. The two enzyme forms may be part of a mechanism for control of concentration of cyclic adenosine monophosphate. PMID- 4333172 TI - Division of Biologics Standards: scientific management questioned. PMID- 4333173 TI - Loss of a parathyroid hormone-sensitive component of phosphate transport in X linked hypophosphatemia. AB - Mutant hemizygotes with X-linked hypophosphatemia lack a parathyroid hormone sensitive component of inorganic phosphate transport in kidney; female heterozygotes retain a variable proportion of this type of transport. The residual mechanism for reabsorption in affected males allows inorganic phosphate efflux from the kidney to urine so that net "secretion" is sometimes observed; the latter is directly proportional to the serum concentration of inorganic phosphate. Calcium acts on the kidney tubule to enhance net reabsorption by this component of inorganic phosphate transport. PMID- 4333174 TI - [Silicosis examination and prophylactic measures in a Norwegian mining operation]. PMID- 4333175 TI - [Silicates and renal calculi]. PMID- 4333176 TI - [Results of treating malignant tumors of the soft tissues of the extremities and trunk]. PMID- 4333177 TI - [The effect of modifying factors on survival in breast cancer]. PMID- 4333178 TI - [An electrophoretic analysis of the serum proteins and soluble liver proteins of mice during experimental hepatocarcinogenesis]. PMID- 4333179 TI - [Thymidine and thymidilate kinases from transplantable rat tumors and homologous tissues]. PMID- 4333180 TI - [Induction of liver tumors in mice by simian adenovirus SA (C8)]. PMID- 4333181 TI - [Combinations of skin cancer and malignant tumors of other localities]. PMID- 4333182 TI - [Contamination of the population with rhinovirus type 1A, 1B and 7]. PMID- 4333183 TI - [Technic of hemagglutination inhibition test in para-influenza virus infections]. PMID- 4333184 TI - [Epidemiological and antigen studies on the significance of the adenovirus complement fixation reaction]. PMID- 4333186 TI - Cranial suture closure in two species of South American monkeys. PMID- 4333185 TI - Variations in the response of the immature rat and its arenal gland to ACTH. PMID- 4333187 TI - Hyperbaric radiation therapy. Preliminary results of a randomized study of cancer of the urinary bladder and review of the "oxygen experience". PMID- 4333188 TI - Granular cell myoblastoma of the trachea. Response to radiation therapy. PMID- 4333189 TI - The role of radiotherapy and chemotherapy in the surgical management of pulmonary metastases. PMID- 4333190 TI - [Experimental study of the sensitizing properties of the antibiotics phytobacteriomycin and polymycin]. PMID- 4333191 TI - [Sex chromatin in neutrophilic leukocytes in the blood of children treated with antibiotics]. PMID- 4333192 TI - Inhibition and kinetic mechanism of rabbit muscle glyceraldehyde-3-phosphate dehydrogenase. PMID- 4333193 TI - Physicochemical studies of the relation between structure and function in hemoglobin Hiroshima (HC3 , histidine leads to aspartate). PMID- 4333194 TI - Specific tritium labeling of uridine diphosphogalactose 4-epimerase by D-(1- 3 H) galactose. PMID- 4333195 TI - Interaction between uridine diphosphate galactose and uridine diphosphate galactose 4-epimerase from Escherichia coli. PMID- 4333196 TI - Incorporation of leucine into rhodopsin in isolated bovine retina. PMID- 4333199 TI - Inhibition of micrococcal nuclease with 5'-deoxythymidine-5'-phosphonic acid containing oligomers. PMID- 4333198 TI - Coupling of oxidative phosphorylation by monovalent cations. PMID- 4333197 TI - Inhibition of electron and energy transfer in rat liver mitochondria by nordihydroguaiaretic acid. PMID- 4333201 TI - Electronic, hydrophobic, and steric effects of binding of inhibitors to the horse liver alcohol dehydrogenase-reduced pyridine coenzyme binary complex. PMID- 4333200 TI - A nuclear magnetic resonance study of the influence of aqueous sodium perchlorate and temperature on the solution conformations of uracil nucleosides and nucleotides. PMID- 4333203 TI - [Structure of viral particles produced by the strain of rat cells 17 RBI 77 transformed by the virus B 77]. PMID- 4333202 TI - Threonine deaminase from extremely halophilic bacteria. Cooperative substrate kinetics and salt dependence. PMID- 4333204 TI - [Effect of pH reduction on the development of vesicular stomatitis virus]. PMID- 4333205 TI - The effect of methoxyflurane on baroreflex control of heart rate in man. PMID- 4333206 TI - [Systematized lentiginosis with congenital deafness and discrete status dysraphicus]. PMID- 4333207 TI - Behavior of mesencephalic reticular neurons in sleep and wakefulness. PMID- 4333208 TI - Electromyography in small animal clinical neurology. PMID- 4333209 TI - Evaluation in calves of an inactivated bovine rhinotracheitis and parainfluenza-3 vaccine combined with Pasteurella bacterin. PMID- 4333210 TI - Studies on primary cultures of differentiated fetal liver cells. AB - A method for culturing non- or slowly growing, differentiated fetal rat liver cells is described. It involves the use of collagenase as a digesting agent and of a selective medium deficient in arginine which suppresses the growth of nonparenchymal liver cells. Evidence is presented that surviving cells (a) retain liver-specific urea cycle functions measured by their capacity to transform ornithine into arginine, (b) synthesize DNA in glucose-deficient medium, and (c) synthesize and secrete albumin. This primary cell culture responds to partially hepatectomized rat serum and may be an appropriate assay system for the study of mechanisms which regulate liver regeneration. PMID- 4333212 TI - Cytochalasin B and pigment granule translocation. Cytochalasin B reverses and prevents pigment granule dispersion caused by dibutyryl cyclic AMP and theophylline in Rana pipiens Melanocytes. PMID- 4333213 TI - Membranes of mammary gland. 3. Lipid composition of Golgi apparatus from rat mammary gland. PMID- 4333211 TI - Transformation of trophic Hartmannella culbertsoni into viable cysts of cyclic 3',5'-adenosine monophosphate. PMID- 4333214 TI - [Problems raised by corticoid treatments in West's disease and in very severe epilepsy in young children]. PMID- 4333216 TI - [Nitrofurantoin-induced polyneuropathy]. PMID- 4333215 TI - [Peripheral nervous system changes due to the local action of mechanical vibration]. PMID- 4333217 TI - Peripheral nerve lesions of the upper limb and lively splints. PMID- 4333218 TI - [Case of histiocytoma]. PMID- 4333219 TI - Modification of the cat sleep cycle by hemicholinium-3, a cholinergic antisynthesis agent. PMID- 4333220 TI - Stereochemistry of the binding of aliphatic amides to horse liver alcohol dehydrogenase-reduced diphosphopyridine nucleotide binary complex. PMID- 4333221 TI - Hypercalcemic and hypermagnesemic perfusion of isolated autotransplanted adrenal glands. PMID- 4333223 TI - [Case of Zollinger-Ellison syndrome]. PMID- 4333222 TI - [Interesting side effects]. PMID- 4333225 TI - The fine structure of sensory neurons and their processes in the optic tentacles of Helix aspera. PMID- 4333224 TI - [Histochemical studies of epithelial enzymes in the small intestine of young inbred rats]. PMID- 4333226 TI - Mechanisms of utilization of oxygen. PMID- 4333227 TI - Herpes Zoster-Varicella infections and lymphoma. PMID- 4333228 TI - Varicella-Zoster infection in patients with cancer. PMID- 4333230 TI - Behcet's disease. PMID- 4333229 TI - Chronic lymphocytosis with lymphocyte inclusions. PMID- 4333231 TI - The role of the epidermis in the histopathogenesis of lichen planus. Histochemical correlations. PMID- 4333232 TI - Nirogen dioxide effects on alveolar macrophages. PMID- 4333233 TI - Immunological and related aspects of nasopharyngeal carcinoma. PMID- 4333234 TI - Ultrastructure and RNA synthesis in a molluscan giant neuron under electrical stimulation. PMID- 4333235 TI - Permanent reduction in sleep after removal of cerebral cortex and striatum in cats. PMID- 4333236 TI - The reaction of monofluorophosphate with apatite. PMID- 4333237 TI - [Recent findings in the etiopathogenesis of subacute sclerosing panencephalitis]. PMID- 4333238 TI - [Diagnosis of benign cell synovialoma]. PMID- 4333239 TI - Complement fixing antibody to herpes simplex virus in patients with psychotic depression. PMID- 4333240 TI - [Experiences with Mowlem-Obwegeser's decortication in chronic osteomyelitis]. PMID- 4333241 TI - [Local interferon-production in the respiratory- and genital tract following infection with rhinotracheitis (IBR) and herpes exanthema (IPV) virus]. PMID- 4333243 TI - Leucyl-tRNA synthetase. Two forms of the enzyme: role of sulfhydryl groups. PMID- 4333242 TI - Development of mitochondrial enzyme activities in rat-small-intestinal epithelium. PMID- 4333244 TI - Alteration of cyclic 3',5'-adenosine monophosphate action on adenosine 5' triphosphate induced muscular contraction by a serum enzyme. PMID- 4333245 TI - The effect of NADH and NAD+ on the proteolysis of lactate dehydrogenase isozymes by trypsin. PMID- 4333247 TI - Role of serotonin in morphine effects. PMID- 4333246 TI - Bulbospinal serotonin-containing neurons and motor control. PMID- 4333248 TI - Serotonin and behavior: a brief summary. PMID- 4333249 TI - Drug-induced anemia. PMID- 4333250 TI - Biogenesis of mitochondrial inner membranes in bakers' yeast. PMID- 4333253 TI - Effects of serotonin on central neurons: microiontophoretic administration. PMID- 4333251 TI - Ontogenesis of the adrenergic nervous system: functional and pharmacologic implications. PMID- 4333252 TI - Influence of drugs on the firing of serotonin-containing neurons in brain. PMID- 4333254 TI - Adenohypophysial control of extrarenal excretion in the duck (Anas platyrhynchos). PMID- 4333256 TI - [Hypoglycemic attacks and convulsions due to an islet cell tumor in a 7-year-old girl]. PMID- 4333255 TI - Metabolic response to temperature acclimation and T 4 in the water snake. PMID- 4333257 TI - Hypophosphataemic vitamin D-resistant rickets; an observation on height and serum inorganic phosphate in untreated cases. PMID- 4333258 TI - The site of auramine O binding to horse liver alcohol dehydrogenase. PMID- 4333259 TI - Fat metabolism in higher plants. 48. Properties of oleyl coenzyme A desaturase of Carthamus tinctorius. PMID- 4333260 TI - Electron spin resonance studies of spin-labeled carbonic anhydrase. PMID- 4333261 TI - Stimulation of ribonucleic acid synthesis in horse lymphocyte by exogenous cyclic adenosine 3',5'-monophosphate. PMID- 4333262 TI - Oxidation of glycerol 3-phosphate by the perfused rat liver. PMID- 4333263 TI - Deoxyribonucleic acid plymerase II. of Escherichia coli. I. The purification and characterization of the enzyme. PMID- 4333265 TI - Bull semen nicotinamide adenine dinucleotide nucleosidase. 3. Properties of the substrate binding site. PMID- 4333264 TI - Bull semen nicotinamide adenine dinucleotide nucleosidase. II. Physical and chemical studies. PMID- 4333266 TI - The kinetics of the reactions of leghemoglobin with oxygen and carbon monoxide. PMID- 4333267 TI - Studies on methemoglobin reductase. II. The purification and molecular properties of reduced nicotinamide adenine dinucleotide-dependent methemoglobin reductase. PMID- 4333268 TI - A lactate dehydrogenase specific specific to the liver of gadoid fish. PMID- 4333269 TI - Phagocytosis of latex beads by isolated thyroid cells: effects of thyrotropin, prostaglandin E 1 , an dibutyryl cyclic AMP. PMID- 4333270 TI - The passage of cytoplasmic vesicles across endothelial and mesothelial cells. PMID- 4333271 TI - Cytochemical localization of ATP-ase activity in plant root cells. PMID- 4333272 TI - Somatotropin, thyrotropin and corticotropin hormone-induced changes in the cartilages and bones of the shoulder and knee joint in young dogs. An experimental study using histological OTC, bone labelling and microradiographic methods. PMID- 4333273 TI - Response of pulmonary vascular segments to angiotensin and norepinephrine. PMID- 4333274 TI - Electron microscopical studies on rat brain neurons. Localization of acid phosphatase and mode of formation of lipofuscin bodies. PMID- 4333275 TI - Cytoplasmic microfilaments in plant cells. PMID- 4333276 TI - Drug treatment of convulsive disorders. PMID- 4333277 TI - Biological properties of Escherichia coli isolated from pathological material. PMID- 4333278 TI - Parasympathetic ganglia: activation of an adrenergic inhibitory mechanism by cholinomimetic agents. AB - Electrical stimulation of the sympathetic nerves to the urinary bladder or the intraarterial administration of the cholinomimetic substances acetylcholine or methacholine produced adrenergic inhibition in parasympathetic ganglia on the surface of the bladder. The inhibition appeared to be mediated, at least in part, via adrenergic inhibitory neurons located in the pelvic plexus. Atropine blocked the inhibitory response to injected cholinomimetic agents but did not alter the response to stimulation of the sympathetic nerves. Thus, the inhibitory neurons can be activated via both muscarinic and nonmuscarinic receptors, the latter being of primary physiological importance. PMID- 4333279 TI - [Preventive therapy of cerebral palsy in children]. PMID- 4333280 TI - [Methods for interdigital commissure repair in syndactylia]. PMID- 4333281 TI - Morphologic features of mammary carcinomas in women taking hormonal contraceptives. PMID- 4333282 TI - Rapid method for detection of erythrocyte NADH-methemoglobin reductase deficiency. PMID- 4333283 TI - [Stimulation of somatotropic hormone secretion by beta 1-24 corticotrophin]. PMID- 4333284 TI - [Use of carbamoyl-dibenzo-azepine (Tegretol) in the therapy of diabetes insipidus]. PMID- 4333285 TI - [Hypercortisolism and hyperthyrocalcitonism in a case of thyroid medullary cancer secreting ACTH and thyrocalcitonin]. PMID- 4333286 TI - [Negative responses to metopirone in Cushing's syndrome due to adrenal cortex adenoma or adenomatosis]. PMID- 4333287 TI - [A case of thecoma of the ovary. (Hormonology, fine structure, histochemistry, incubation)]. PMID- 4333288 TI - [Osteoid fibroangioma]. PMID- 4333289 TI - [The effect of ristomycin on the growth of its producer--Proactinomyces fructiferi var. ristomycini--and on some of its metabolic processes]. PMID- 4333290 TI - [Development and introduction of an industrial method for the production of ristomycin]. PMID- 4333293 TI - [Effect of tissue culture cells on the biological activity of antibiotics]. PMID- 4333291 TI - [How to obtain specific pathogen-free mice by the antibiotic decontamination method]. PMID- 4333292 TI - [Comparative in vitro study of antibiotic resistance increase in classical cholera and E1 Tor vibrios]. PMID- 4333294 TI - [Distribution of antibiotic resistance of enteric microblora in cattle on farms of the Amur and Chita region]. PMID- 4333295 TI - Reaction of 2-bromoacetamide-4-nitrophenol with heavy meromyosin ATPase. PMID- 4333297 TI - Iron-sulphur proteins in the succinate oxidase system. PMID- 4333296 TI - The effect of ATP on the EPR spectrum of phosphorylating sub-mitochondrial particles. PMID- 4333298 TI - Biochemical and biophysical studies on cytochrome aa 3 . IV. Some properties of oxygenated cytochrome aa 3 . PMID- 4333299 TI - Subunit interaction in horse liver alcohol dehydrogenase: 35 Cl nuclear magnetic resonance studies. PMID- 4333300 TI - [Soluble conjugated estrogens in the prevention of hemorrhages in eye surgery]. PMID- 4333301 TI - [Determination and localization of calcium in the lipids of mouse brain]. PMID- 4333302 TI - Some aspects of the search for a human mammary tumor virus. PMID- 4333303 TI - Immunological considerations and the malignant glioma problem. PMID- 4333304 TI - Neural and vascular compression syndromes of the shoulder girdles and arms. PMID- 4333305 TI - Long term toxicity studies with endotoxoid in monkeys. PMID- 4333306 TI - Synaptic connections made by two serotonin-containing neurons in the snail (Helix pomatia) brain. PMID- 4333307 TI - Functional anatomy of frog's taste organs. PMID- 4333309 TI - Immune responses in amebiasis. PMID- 4333310 TI - [Immediate effects of various antibiotics on electro-osmosis in Nitella flexilis L]. PMID- 4333308 TI - Effect of bacterial antigens, propranolol, and insulin on the susceptibility of mice to hypothermic stress. PMID- 4333311 TI - Encephalomyocarditis viral valvulitis in new-born mouse. PMID- 4333312 TI - [Automatic analysis of polyraph recordings of sleep]. PMID- 4333313 TI - Viral infections in man associated with acquired immunological deficiency states. PMID- 4333314 TI - Clinico-virological study of cases of diarrhea in infancy and childhood. PMID- 4333315 TI - Autonomic nerves and their transmitters in hypothermia. PMID- 4333316 TI - Oxidative phosphorylation in fractionated bacterial systems: effect of chloramphenicol. AB - Chloramphenicol was found to have a direct effect on the respiratory chain of Mycobacterium phlei cells grown in the presence of this drug. Analysis of the respiratory chain components revealed that the presence of chloramphenicol during growth resulted in a partial inhibition in the synthesis of the cytochromes. However, a stimulation in oxidative phosphorylation was observed with the cell free extract of cells grown in the presence of chloramphenicol. The oxidation of succinate was found to be stimulated 20 to 130%, depending on the particular extract, whereas the oxidation of reduced nicotinamide adenine dinucleotide (NADH) was found to be similar to that of extracts obtained from cells grown in the absence of the drug. Of particular interest was the finding that the cell free extract of cells grown in the presence of the drug exhibited an increased level of phosphorylation (17 to 100%) when NADH was used as the electron donor. Chloramphenicol appears to affect a component of the respiratory chain between the flavoprotein and cytochrome c. Fractionation of the electron transport particles revealed an increased level of cytochrome b in the fractions which exhibited a stimulation in oxidative phosphorylation. PMID- 4333318 TI - Cyanide-resistant respiration in Neurospora crassa. AB - Cell respiration in wild type and poky was studied as part of a long-term investigation of cyanide-resistant respiration in Neurospora. Respiration in wild type proceeds via a cytochrome chain which is similar to that of higher organisms; it is sensitive to antimycin A or cyanide. Poky, on the other hand, respires by means of two alternative oxidase systems. One of these is analogous to the wild-type cytochrome chain in that it can be inhibited by antimycin A or cyanide; this system accounts for as much as 15% of the respiration of poky f(-) and 34% of the respiration of poky f(+). The second oxidase system is unaffected by antimycin A or cyanide at concentrations which inhibit the cytochrome chain maximally. It can, however, be specifically inhibited by salicyl hydroxamic acid. The cyanide-resistant oxidase is not exclusive to poky, but is also present in small quantities in wild type grown under ordinary circumstances. These quantities may be greatly increased (as much as 20-fold) by growing wild type in the presence of antimycin A, cyanide, or chloramphenicol. PMID- 4333317 TI - Adenylate energy charge in Escherichia coli during growth and starvation. AB - The value of the adenylate energy charge, [(adenosine triphosphate) + (1/2) (adenosine diphosphate)]/[(adenosine triphosphate) + (adenosine diphosphate) + (adenosine monophosphate)], in Escherichia coli cells during growth is about 0.8. During the stationary phase after cessation of growth, or during starvation in carbon-limited cultures, the energy charge declines slowly to a value of about 0.5, and then falls more rapidly. During the slow decline in energy charge, all the cells are capable of forming colonies, but a rapid fall in viability coincides with the steep drop in energy charge. These results suggest that growth can occur only at energy charge values above about 0.8, that viability is maintained at values between 0.8 and 0.5, and that cells die at values below 0.5. Tabulation of adenylate concentrations previously reported for various organisms and tissues supports the prediction, based on enzyme kinetic observations in vitro, that the energy charge is stabilized near 0.85 in intact metabolizing cells of a wide variety of types. PMID- 4333319 TI - Catalytic properties and regulatory diversity of inorganic pyrophosphatases from photosynthetic bacteria. AB - Soluble inorganic pyrophosphatases of five species of nonsulfur purple bacteria were investigated in respect to reaction kinetics, regulatory behavior, and other characteristics. The enzymes appear to fall into two groups with correlated properties. The pyrophosphatases of Rhodopseudomonas capsulata and R. spheroides have molecular weights of approximately 60,000, are stabilized by Co(2+), and exhibit simple Michaelis-Menten reaction kinetics. On the other hand, the enzymes of R. palustris, R. gelatinosa, and Rhodospirillum rubrum are larger (molecular weight approximately 100,000), require Zn(2+) for maintenance of catalytic activity, and show complex reaction kinetics; these pyrophosphatases are activated by free Mg(2+) ions and, in the absence of the latter, are inhibited by 2-phosphoglyceric acid. The results described indicate the existence of alternative control patterns for regulation of intracellular turnover of phosphate, which is in part mediated by pyrophosphatases. PMID- 4333320 TI - Nicotinamide adenine dinucleotide-dependent and nicotinamide adenine dinucleotide independent lactate dehydrogenases in homofermentative and heterofermentative lactic acid bacteria. AB - Three homofermentative (Lactobacillus plantarum B38, L. plantarum B33, Pediococcus pentosaceus B30) and three heterofermentative (Leuconostoc mesenteroides 39, L. oenos B70, Lactobacillus brevis) lactic acid bacteria were examined for the presence or absence of nicotinamide adenine dinucleotide (NAD) dependent and NAD-independent d- and l-lactate dehydrogenases. Two of the six strains investigated, P. pentosaceus and L. oenos, did not exhibit an NAD independent enzyme activity capable of reducing dichlorophenol indophenol. The pH optima of the lactic dehydrogenases were determined. The NAD-dependent enzymes from homofermentative strains exhibited optima at pH 7.8 to 8.8, whereas values from 9.0 to 10.0 were noted for these enzymes from heterofermentative organisms. The optima for the NAD-independent enzymes were between 5.8 and 6.6. The apparent Michaelis-Menten constants determined for both NAD and the substrates demonstrated the existence of a greater affinity for d- than l-lactic acid. A comparison of the specific NAD-dependent and NAD-independent lactate dehydrogenase activities revealed a direct correlation of the d/l ratios of these activities with the type of lactic acid produced during the growth of the organism. PMID- 4333321 TI - Influence of carboxylic acids on the stereospecific nicotinamide adenine dinucleotide-dependent and nicotinamide adenine dinucleotide-independent lactate dehydrogenases of Leuconostoc mesenteroides. AB - Leuconostoc mesenteroides increased its lactic acid production from glucose threefold when malic acid was added to the culture. This increase resulted also in a reduction of the ratio of d-lactic acid to l-lactic acid (31.5 to 1.23). Addition of malic acid increased 6.5-fold the specific activity of nicotinamide adenine dinucleotide (NAD)-linked l-lactate dehydrogenase and increased 3.2-fold that of NAD-linked d-lactate dehydrogenase. The Michaelis constant (K(m)) for NAD of the NAD-linked l-lactate dehydrogenase increased with the addition of malate, but no change was observed in the K(m) values for the respective d-enzyme. The effect of carboxylic acids on the NAD-linked l-lactate dehydrogenase activities was tested by using partially purified enzyme preparations from cells grown with glucose alone and from cells grown with glucose plus malate. Malate stimulated the l-enzyme and inhibited the d-lactate dehydrogenase. The NAD-linked l-lactate dehydrogenase exhibited the same activity bands on polyacrylamide gel electrophoresis whether the cell-free preparation originated from cells grown on glucose plus malate or on glucose as the sole carbon source. The NAD-linked d lactate dehydrogenase, however, exhibited a different pattern of electrophoretic mobility, depending upon the source of origin of the cell-free preparation. The results suggest that malate has a stimulatory effect on the synthesis of both enzymes and may result in rearrangement of the protein structure of the d-lactate dehydrogenase. This rearrangement apparently makes the d-enzyme more susceptible to inhibition of catalytic activity. The l-lactate dehydrogenase, however, is stimulated not only in its synthesis but also in its activity. It is proposed that these effects are responsible for the regulation of lactic acid production. PMID- 4333322 TI - Role of cyclic adenosine 3',5'-monophosphate and the cyclic adenosine 3',5' monophosphate receptor protein in the initiation of lac transcription. PMID- 4333323 TI - Rapid analytical gel chromatography of proteins and peptides on sephadex microbore columns. PMID- 4333324 TI - Oxidative phosphorylation by pyridoxine-deficient rat brain mitochondria. PMID- 4333325 TI - Distribution and turnover of octopamine in tissues. PMID- 4333326 TI - Protein synthesis in vitro in nuclei of human nervous tissue. PMID- 4333328 TI - [Treatment of small seizures in children with radedorm (AWD)]. PMID- 4333327 TI - The relationship glycolytic and mitochondrial enzymes in the developing rat brain. PMID- 4333329 TI - The direct effects of dusts on lung fibroblasts grown in vitro. PMID- 4333330 TI - [Preliminary reports on pulmonary circulation in silicosis studied with a new radioiodinated lipid tracer]. PMID- 4333331 TI - The role of adrenocorticotropin and calcium in adenosine cyclic 3', 5'-phosphate production and steroid release from the isolated, perfused cat adrenal gland. PMID- 4333332 TI - Carbohydrate free diet in rats. PMID- 4333333 TI - [Diagnosis of somatotropic insufficiency. Efficiency and tolerance of the beta 1 24-corticotrophin test]. PMID- 4333334 TI - [Abdominal emergencies due to Entamoeba histolytica]. PMID- 4333335 TI - [Features of leukocyte reactions in monkeys under chronic irradiation in low doses]. PMID- 4333336 TI - [Adrenocorticotropic function of the pituitary gland during irradiation]. PMID- 4333337 TI - Arteriovenous shunting in a regenerating liver simulating hepatoma. Report of a case. PMID- 4333338 TI - Lipid embolization to the kidney and brain after lymphangiography. PMID- 4333339 TI - Diagnosis of hepatoma using a multiple radionuclide approach. PMID- 4333340 TI - [The adrenergic system and angiotensin in cardiovascular regulation]. PMID- 4333341 TI - [Hormone-active tumors of the pancreas]. PMID- 4333342 TI - [Nerve conduction velocity in chronic and acute renal insufficiency]. PMID- 4333343 TI - Isolation of bovine adenovirus type 1 from a calf with pneumo-enteritis. PMID- 4333344 TI - [Comparative evaluation of methods of treatment of early stages of malignant ovarian neoplasms]. PMID- 4333345 TI - [Clinico-pathogenetic forms of the virilism syndrome]. PMID- 4333346 TI - [Malignant bilateral ovarian arrhenoblastoma]. PMID- 4333347 TI - The effect N-ethylmaleimide on peptide hormone lacking a disulfide bridge. PMID- 4333348 TI - Vertebral osteophytosis in prehistoric populations of central and southern Mexico. PMID- 4333349 TI - Trabecular involution in femoral heads of a prehistoric (X-group) population from Sudanese Nubia. PMID- 4333350 TI - [Hyperplasia and neoplasia of Schwann cells. Ultrastructural study]. PMID- 4333351 TI - Pharmacology and pathophysiology of inflammation. PMID- 4333352 TI - [Cancer of the liver in rats with alimentary cirrhosis]. PMID- 4333353 TI - [Morphologic and biologic characteristics of experimental tumors of the cerebellum in rats]. PMID- 4333354 TI - [Benign tumor of the sweat glands of complex composition with eccrine spiradenoma and cylindroma structures]. PMID- 4333355 TI - [Isolation of foot-and-mouth disease virus from bovine semen]. PMID- 4333356 TI - [Effect of 6-dehydro-16-methylene-hydrocortisone and dexamethasone on hypothalamo hypophyseal-adrenal cortex-system]. PMID- 4333357 TI - [Septic gas gangrene with unusual focus of infection]. PMID- 4333359 TI - [Diagnosis of malignant synovioma based on our findings]. PMID- 4333358 TI - The subendothelium and thrombogenesis. PMID- 4333360 TI - [Malignant synovioma of the foot]. PMID- 4333361 TI - [Teratoblastoma of the lung (embryonal adenosarcoma)]. PMID- 4333362 TI - Enzyme activity in cryobiological systems. 3. Low-temperature properties of honeybee glyceraldehydephosphate dehydrogenase. PMID- 4333363 TI - [Orthodontic diagnosis in endocrine and apparently endocrine dwarfism]. PMID- 4333364 TI - [Prosthetic treatment after surgical removal of tumors in the jaw region]. PMID- 4333365 TI - Electron-transfer reactions between redox proteins from a bacterium (Pseudomonas fluorescens) and mammalian-heart muscle. PMID- 4333366 TI - Relationships between the 3 - and 20 -hydroxysteroid. NAD-oxidoreductase activity of a crystalline-enzyme preparation. PMID- 4333367 TI - Metabolic instability of myelin protein and proteolipid fractions. PMID- 4333368 TI - The interaction of cyanide with cytochrome oxidase. PMID- 4333369 TI - The 50-mile bridge: consultation between state hospital and community mental health center staffs. PMID- 4333370 TI - More efficient intake and aftercare procedures. PMID- 4333371 TI - [Antibiotic therapy: general principles, principle antibiotics, their indications and side effects]. PMID- 4333372 TI - Epstein-Barr and other herpes virus antibodies in children with acute leukemia. PMID- 4333373 TI - Regulation of penicillinase synthesis: a mutation in Staphylococcus aureus unlinked to the penicillinase plasmid that reduced penicillinase inducibility. AB - A mutant of Staphylococcus aureus strain 655 was isolated that is restricted in penicillinase induction. Wild-type plasmids that bear penicillinase determinants could not be fully induced in this mutant, 655par-1; hence, the responsible mutation is not located on the plasmid. Mutant plasmid PI(258)penI443, which produces penicillinase constitutively in wild-type cells, was fully constitutive for penicillinase production when it was harbored by mutant 655par-1. Therefore, the bacterial mutation does not interfere directly with the transcription of the penZ gene or translation of the penicillinase messenger ribonucleic acid. Mutant plasmid PII(147)penI220 was fully inducible in the mutant bacterium, even though the wild-type plasmid PII(147) was only partially inducible in the par-1 mutant. Thus, in the presence of inducer, complementation appears to occur between the product of the par-1 gene and the product of the penI220 gene. These results suggest that the par-1 gene codes for a penicillinase antire-pressor. PMID- 4333374 TI - Regulation of staphylococcal penicillinase synthesis. AB - 5-Methyl tryptophan was found to be an efficient inducer of penicillinase synthesis in Staphylococcus aureus. Addition of actinomycin D or tryptophan to the culture medium shuts off the 5-methyl tryptophan-induced synthesis of penicillinase with an apparent half-life of approximately 1 to 2 min, respectively. Hence, in the induction of penicillinase synthesis, 5-methyl tryptophan seems to function as a structural analogue of penicillin rather than by becoming incorporated in proteins and thereby creating faulty penicillinase repressor or antirepressor. This conclusion is supported by similarities in the structures of the two compounds as revealed by solid atomic models. The fact that S. aureus exposed to (14)C-penicillin in the absence of protein synthesis failed to synthesize penicillinase at an increased level when cell growth was resumed strongly suggests that a protein involved in the regulation of penicillinase synthesis must be synthesized in the presence of the penicillinase inducer. In turn, this observation suggests that the penicillinase inducer promotes penicillinase synthesis by directing the penicillinase regulatory protein (i.e., the penicillinase antirepressor) to acquire a different conformation when it is synthesized in the presence of the penicillinase inducer. A working model for the regulation of penicillinase synthesis based on these and other data has been constructed and is presented. PMID- 4333375 TI - Mutants of Escherichia coli K-12 blocked in the final reaction of ubiquinone biosynthesis: characterization and genetic analysis. AB - The ubiquinone precursor 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1, 4 benzoquinone was isolated from two ubiquinone-deficient mutants of Escherichia coli and identified by nuclear magnetic resonance and mass spectrometry. The results of genetic analysis of the mutants indicate that each mutant carries a mutation in a gene designated ubiG which was located, by cotransduction with the nalA and glpT genes, at minute 42 on the E. coli chromosome. PMID- 4333376 TI - Formate dehydrogenase from Clostridium acidiurici. AB - Partial purification of formate dehydrogenase from Clostridium acidiurici has been accomplished, and some properties of the enzyme have been determined. The molecular weight of the protein is at least 200,000 daltons. The enzyme showed marked instability to freezing and thawing and was inhibited strongly by oxygen and by light. Such inhibition was not reversed by incubation in the presence of thiol compounds. Cyanide inhibited the enzyme 90% at 0.1 mm concentrations, but ethylenediaminetetraacetate produced only slight inhibition at concentrations as high as 50 mm. The purified enzyme showed no ferredoxin activity in the Clostridium pasteurianum clastic system during pyruvate oxidation. Crude preparations of the enzyme could be coupled through ferredoxin to the reduction of nicotinamide adenine dinucleotide during formate oxidation, but the purified enzyme could not catalyze the reduction of pyridine nucleotides by formate in the presence of ferredoxin. Formate oxidation with the purified enzyme was readily coupled to benzyl viologen reduction, in which case ferredoxin was not required. An exchange between formate and bicarbonate was catalyzed by both crude and purified preparations of the enzyme, but the net synthesis of formate from CO(2) was not accomplished. PMID- 4333377 TI - Fatty acid desaturase mutants of yeast: growth requirements and electron spin resonance spin-label distribution. AB - Two respiratory-sufficient and one respiratory-deficient (nuclear petite) strains of yeast Delta(9)-desaturase mutants were analyzed to determine which fatty acids would serve as replacements for the naturally occurring fatty acids, 16:1 Delta(9)cis and 18:1 Delta(9)cis. The requirement can be satisfied by several fatty acids differing in double-bond position, steric configuration, chain length, and degree of unsaturation. The features common to growth-supporting fatty acids are presented and the effects of varying the carbon source and temperature are considered. In addition, we illustrate several pitfalls encountered in membrane studies which exploit lipid-requiring organisms. Since the membrane fatty acid composition of these mutants can be modified readily, electron spin resonance spectroscopy is used to compare membranes of mutant strains enriched for different fatty acids. The lipid distribution pattern of the most commonly employed electron spin resonance spin-label, 12-nitroxide stearate, was ascertained and compared to that of 18:1 Delta(9)cis. PMID- 4333378 TI - Genetic and physiological control of serine and glycine biosynthesis in Saccharomyces. AB - Two of the three known metabolic pathways to serine and glycine have been shown to be present in prototrophic yeast strains, i.e., the phosphorylated pathway from glycolytic intermediates and the glyoxylate pathway from tricarboxylic acid cycle intermediates. Two serine-glycine auxotrophs (ser1 and ser2) were found to be blocked in the phosphoglycerate pathway. The ser1 gene controls l glutamate:phosphohydroxypyruvate transaminase biosynthesis, and the ser2 gene controls phosphoserine phosphatase biosynthesis. The other pathway to glycine, from isocitrate, is repressed by growth in glucose media, specifically, at isocitrate lyase and at the alanine:glyoxylate transaminase. This pathway is derepressed by growth to stationary phase in glucose media yielding high activity of these enzymes. The phosphorylated pathway appears to be the principal biosynthetic pathway to serine and glycine during growth on sugar media. Strains which are serine-glycine dependent in glucose media became capable of serine glycine independent growth on acetate media. These results describe a method of physiological control of a secondary metabolic pathway allowing a single lesion in the principal biosynthetic pathway to produce auxotrophy. This may be termed conditional auxotrophy. PMID- 4333379 TI - Method for isolating mutants overproducing nicotinamide adenine dinucleotide and its precursors. AB - A procedure has been developed for isolating mutants which are defective with respect to nicotinamide adenine dinucleotide (NAD) metabolism. It is based on the well known V-factor requirement of Haemophilus parainfluenzae. This procedure was used to isolate a series of mutants from Escherichia coli. The pyridine metabolism of wild-type and mutant E. coli cells falls in one of four distinct classes. Class A includes wild-type E. coli and represents strains that are normal with respect to pyridine metabolism. Class B mutants have altered internal pools of NAD. The intracellular NAD concentration of different class B mutants varies over a 10-fold range. Class C mutants excrete pyridine mononucleotides, and class D mutants excrete NAD. The production of pyridine nucleotides by class C and D mutants exceeds that of wild-type E. coli by a factor of at least ten. The mutant strains generally have normal generation times and achieve normal cell densities in minimal medium. PMID- 4333381 TI - Phenotype of a temperature-sensitive, respiration-deficient (cyt) mutant of yeast. AB - A temperature-sensitive respiration-deficient mutant of yeast lacks hemoproteins and accumulates coproporphyrin III when cultivated at elevated temperatures. Cells grown at 20 C respired normally and contained cytochromes a, b, and c. Cells grown at 35 C showed respiration-deficient mutant characters; they did not respire, lacked cytochromes, and accumulated coproporphyrin III. Addition of protoporphyrin IX or protohemin IX to the culture medium restored the respiratory activity of this mutant during growth at 35 C. The activities of various enzymes, including succinate-2,6-dichlorophenol indophenol (DCPIP), reduced nicotinamide adenine dinucleotide (NADH(2))-DCPIP, succinate-cytochrome c, and NADH(2) cytochrome c oxidoreductase, and cytochrome oxidase, and the cytochrome c content of cells cultured in various conditions were determined. Changes in the number and structure of mitochondria were associated with changes in respiratory activity. PMID- 4333380 TI - Release of the -galactosidase-synthesizing system from ultraviolet catabolite repression by cyclic 3',5'-adenosine monophosphate, dark repair, photoreactivation, and cold treatment. AB - Recovery from the inhibitory effect of ultraviolet irradiation on the induced synthesis of beta-galactosidase was studied in Escherichia coli B/r. When irradiated cells (520 ergs/mm(2) at 254 nm) were induced and incubated in minimal medium supplemented with Casamino Acids (conditions of catabolite repression), the ability to form enzyme was greatly reduced for about 100 min and then recovery began. The inhibition observed immediately after ultraviolet irradiation was partially reversed by cyclic 3',5'-adenosine monophosphate (cyclic AMP) or by photoreactivation treatment. Inhibition was reduced if the cells were given cold treatment (5 C) before or during irradiation; the kinetics of induced enzyme formation in each case were similar to those of irradiated cells receiving cyclic AMP. These kinetics suggest that the cold treatments, like cyclic AMP, cause the release of the beta-galactosidase-synthesizing system from catabolite repression. When irradiated cells were incubated for various times before cyclic AMP or photoreactivation treatment, some reversal of the inhibition of induced enzyme formation was obtained, but by 100 min the treatments were ineffective. Because 100 min was also the time at which dark recovery of enzyme formation began, the recovery process was interpreted to be the result of completion of DNA repair, which, in turn, released the beta-galactosidase-synthesizing system from catabolite repression. PMID- 4333382 TI - Separation of the primary dehydrogenase from the cytochromes of the nicotinamide adenine dinucleotide (reduced form) oxidase of Bacillus megaterium. AB - A selective extraction procedure was developed for sequentially extracting a fraction containing the primary dehydrogenase and a fraction containing the cytochromes of the nicotinamide adenine dinucleotide (reduced form) (NADH) oxidase of Bacillus megaterium KM membranes. The primary dehydrogenase (NADH-2,6 dichlorophenolindophenol oxidoreductase) activity was extracted from sonically treated membranes with 0.4% sodium deoxycholate for 30 min at 4 C. The insoluble residue was extracted with 0.4% sodium deoxycholate in 1 m KCl for 30 min at 25 C. A combination of the two extracts and dilution in Mg(2+) gave good recovery of the original membrane NADH oxidase activity. The primary dehydrogenase fraction contained 41% of the membrane protein, no cytochromes, flavine adenine dinucleotide as the sole acid-extractable flavine, and most of the membrane ribonucleic acid (RNA). The cytochrome-containing fraction had 16% of the membrane protein, 61% of the membrane cytochrome with the same relative amounts of cytochromes a and b as the original membrane, no acid-extractable flavine, little RNA, and no oxidoreductase activity. The oxidoreductase fraction remained soluble after removal of deoxycholate whereas the cytochrome fraction became insoluble after removal of deoxycholate-KCl, but the precipitated fraction could be redissolved in 0.4% sodium deoxycholate. Treatment of both fractions with ribonuclease to destroy all of the RNA present did not affect the ability of the fractions to recombine into a functional oxidase unit. Treatment of either fraction with phospholipase A prevented restoration of a functional oxidase when the oxidoreductase and cytochrome fractions were treated in solution, but no affect on restoration of oxidase was observed when the phospholipase A treatment was carried out with the soluble oxidoreductase fraction and the insoluble cytochrome fraction. PMID- 4333383 TI - Function of ubiquinone in Escherichia coli: a mutant strain forming a low level of ubiquinone. AB - A ubiquinone-deficient mutant of Escherichia coli K-12 forming 20% of the normal amount of ubiquinone was compared with a normal strain. This lowered concentration of ubiquinone is still four times the concentration of cytochrome b(1). The mutant strain grew more slowly than the normal strain on a minimal medium with glucose as sole source of carbon and gave a lower aerobic growth yield than the normal strain. The reduced nicotinamide adenine dinucleotide (NADH) oxidase rate in membranes from the mutant strain was 40% of the oxidase rate in membranes from the normal strain, and the percentage reduction of cytochrome b(1) in the aerobic steady state, with NADH as substrate, was increased in membranes from the mutant strain. It is concluded that ubiquinone is required for maximum oxidase activity at the relatively high concentration (27 times that of cytochrome b(1)) found in normal cells. The results are discussed in relation to a scheme previously advanced for ubiquinone function in E. coli. PMID- 4333385 TI - Analysis of feather germ formation in the embryo and vitro, in normal development and in skin treated with hydrocortisone. PMID- 4333384 TI - Studies on the diversity of inositol-containing yeast phospholipids: incorporation of 2-deoxyglucose into lipid. AB - Seven inositol-containing phospholipids in Saccharomyces cerevisiae can be resolved by two-dimensional chromatography on silicic acid-impregnated paper. Four of these lipids are stable to mild alkaline methanolysis; one of these has already been characterized as a mannosyl di(inositolphosphoryl) ceramide. Addition of labeled 2-deoxy-d-glucose to a growing culture results in label appearing in five lipids, some of which are alkali-stable and have the same R(F) values as the alkali-stable inositol-containing phospholipids. These lipids are labeled rapidly. The deoxyglucose is incorporated intact, probably in a glycosidic link, since the deoxyglucose is released by mild acid treatment. PMID- 4333386 TI - Electrophysiological correlates of the response decrement produced by mechanical stimuli in the protozoan, Stentor coeruleus. PMID- 4333387 TI - Ultrastructure of the microfilaria of Dirofilaria immitis. PMID- 4333389 TI - Nephroblastoma in a striped bass. PMID- 4333388 TI - [Effect of catatoxic steroids on acute and chronic poisoning with aniline]. PMID- 4333390 TI - Cytarabine for herpesvirus infections. PMID- 4333391 TI - [Congenital methemoglobinemia caused by the NADH-diaphorase deficiency]. PMID- 4333392 TI - Reversible vulvar atypia. A case report. PMID- 4333393 TI - Carcinoma of the cervix and genital herpes virus infection. PMID- 4333394 TI - Unilateral streaked ovary syndrome. PMID- 4333395 TI - [The effect of alpha methyldopa and spironolactone on angiotensin sensitivity in man]. PMID- 4333396 TI - Service meetings in a renal transplant unit: an unused adjunct to total patient care. PMID- 4333397 TI - The fluid mosaic model of the structure of cell membranes. AB - A fluid mosaic model is presented for the gross organization and structure of the proteins and lipids of biological membranes. The model is consistent with the restrictions imposed by thermodynamics. In this model, the proteins that are integral to the membrane are a heterogeneous set of globular molecules, each arranged in an amphipathic structure, that is, with the ionic and highly polar groups protruding from the membrane into the aqueous phase, and the nonpolar groups largely buried in the hydrophobic interior of the membrane. These globular molecules are partially embedded in a matrix of phospholipid. The bulk of the phospholipid is organized as a discontinuous, fluid bilayer, although a small fraction of the lipid may interact specifically with the membrane proteins. The fluid mosaic structure is therefore formally analogous to a two-dimensional oriented solution of integral proteins (or lipoproteins) in the viscous phospholipid bilayer solvent. Recent experiments with a wide variety of techniqes and several different membrane systems are described, all of which abet consistent with, and add much detail to, the fluid mosaic model. It therefore seems appropriate to suggest possible mechanisms for various membrane functions and membrane-mediated phenomena in the light of the model. As examples, experimentally testable mechanisms are suggested for cell surface changes in malignant transformation, and for cooperative effects exhibited in the interactions of membranes with some specific ligands. Note added in proof: Since this article was written, we have obtained electron microscopic evidence (69) that the concanavalin A binding sites on the membranes of SV40 virus-transformed mouse fibroblasts (3T3 cells) are more clustered than the sites on the membranes of normal cells, as predicted by the hypothesis represented in Fig. 7B. T-here has also appeared a study by Taylor et al. (70) showing the remarkable effects produced on lymphocytes by the addition of antibodies directed to their surface immunoglobulin molecules. The antibodies induce a redistribution and pinocytosis of these surface immunoglobulins, so that within about 30 minutes at 37 degrees C the surface immunoglobulins are completely swept out of the membrane. These effects do not occur, however, if the bivalent antibodies are replaced by their univalent Fab fragments or if the antibody experiments are carried out at 0 degrees C instead of 37 degrees C. These and related results strongly indicate that the bivalent antibodies produce an aggregation of the surface immunoglobulin molecules in the plane of the membrane, which can occur only if the immunoglobulin molecules are free to diffuse in the membrane. This aggregation then appears to trigger off the pinocytosis of the membrane components by some unknown mechanism. Such membrane transformations may be of crucial importance in the induction of an antibody response to an antigen, as well as iv other processes of cell differentiation. PMID- 4333399 TI - 1,25-dihydroxycholecalciferol: a potent stimulator of bone resorption in tissue culture. AB - 1,25-Dihydroxycholecalciferol (DHCC), isolated from kidney homogenates incubated with 25-hydroxycholecalciferol (HCC), stimulated the release of previously incorporated (45)45Ca from fetal rat bones in organ culture, at concentrations of 10(-10) to 10(-8)M. The dose response curves for 1,25-DHCC and 25-HCC, the parent compound, are parallel, but 1,25-DHCC is about 100 times as potent on a weight basis. Brief exposure to maximum doses of either agent leads to prolonged bone resorption. PMID- 4333398 TI - Cyclic nucleotide phosphodiesterase: high activity in a mammalian photoreceptor. AB - Purified outer segments of bovine rods exhibit phosphodiesterase activity against adenosine and guanosine cyclic 3',5'-monophosphates (cyclic AMP and cyclic GMP). The enzyme hydrolyzed cyclic GMP more rapidly than cyclic AMP at low substrate concentrations. The presence of high phosphodiesterase activity in this highly specialized organelle suggests that this enzyme may function in control of cyclic nucleotide concentration during visual excitation or adaptation. PMID- 4333401 TI - The effect of a prosthetic ventricular septum on canine cardiac function. PMID- 4333400 TI - Pressor responses in portacaval transposition. PMID- 4333402 TI - Chemodectomas. PMID- 4333403 TI - [Blood oxygen pressure as a criterion of pulmonary function and therapy]. PMID- 4333404 TI - [Adrenal cortex and plasma corticosterone modifications in rats in an experimental model of fatique]. PMID- 4333406 TI - Pancreatoduodenectomy: a retrospective review 1949 to 1969. PMID- 4333405 TI - Control of ovulation time with steroid and nonsteroid compounds. PMID- 4333407 TI - Carcinoma of the stomach. 3. Prognosis and some prognostic factors. PMID- 4333409 TI - Preoperatively administered antibiotics. Their effect of bacterial counts of the eyelids. PMID- 4333410 TI - Stimulation of colicin E 1 synthesis by cyclic 3', 5'-adenosine monophosphate in mitomycin C-induced Escherichia coli. PMID- 4333408 TI - Influence of oxygen tension on the physiology of Saccharomyces cerevisiae in continuous culture. PMID- 4333411 TI - Permeation of dibutyryl cAMP into HeLa cells and its convesion to monobutyryl cAMP. PMID- 4333412 TI - Enzymatic activation of the carcinogen 4-hydroxyaminoquinoline-1-oxide and its interaction with cellular macromolecules. PMID- 4333413 TI - Influence of steric specificity on the rates of hydrogen exchange between substrates of NAD-coupled dehydrogenases. PMID- 4333414 TI - Primary processes in photosynthesis: in situ ESR studies on the light induced oxidized and triplet state of reaction center bacteriochlorophyll. PMID- 4333415 TI - The primary electron acceptor in photosynthesis. PMID- 4333416 TI - Quantitative studies on the EPR signals of photosynthetic system I and ferredoxin. PMID- 4333417 TI - Effect of ACTH on cholesterol side-chain cleavage in rat adrenal mitochondria. PMID- 4333418 TI - Activation by 5-phosphoribosyl 1-pyrophosphate of glutamine-dependent carbamyl phosphate synthetase from mouse spleen. PMID- 4333419 TI - Poly ADP-ribose glycohydrolase from rat liver nuclei, a novel enzyme degrading the polymer. PMID- 4333420 TI - Regulatory properties of succinate dehydrogenase: activation by succinyl CoA, pH, and anions. PMID- 4333421 TI - Similarity and pleiotropic actions of adenosine 3',5'-monophosphate-dependent protein kinases from mammalian tissues. PMID- 4333422 TI - Activation of cell membrane enzymes in the stimulation of cell division. PMID- 4333423 TI - Proteinase activity in purified animal viruses. PMID- 4333424 TI - A re-interpretation of bicarbonate-free ferric transferrin E.P.R. spectra. PMID- 4333425 TI - Respiratory control in mitochondria from Crithidia fasciculata. PMID- 4333426 TI - Reconstitution of poliovirus. PMID- 4333427 TI - The identification of an asymmetric complex of nicotinamide adenine dinucleotid and pig heart cytoplasmic malate dehydrogenase. PMID- 4333428 TI - Inhibition of the protein kinase by adenine compounds: competitive inhibition with respect to ATP. PMID- 4333429 TI - Isolation of acid-nonextractable flavins from a bacterial sarcosine oxidase. PMID- 4333430 TI - Spin-labeled yeast cells. PMID- 4333431 TI - Cardiolipin forms hexagonal structures with divalent cations. PMID- 4333432 TI - 2',3'-cyclic nucleotide 3'-phosphohydrolase in human erythrocyte membranes. PMID- 4333433 TI - Preparation of suspensions of washed platelets from humans. PMID- 4333434 TI - Augmentation of caffeine-contracture tension by twitch-potentiating agents in frog toe muscle. PMID- 4333435 TI - Cold-induced vasodilatation in the sheep. PMID- 4333436 TI - Hepatic origin of renin substrate. PMID- 4333437 TI - Another look at neurosis. PMID- 4333438 TI - Selective binding of barbital to the adenine moieties of FAD and NAD. PMID- 4333439 TI - Ribonucleic acid from Plasmodium knowlesi before and after chloroquine treatment. PMID- 4333440 TI - Studies on diphtheria toxin. The effect of GTP on the toxin-dependent adenosine diphosphate ribosylation of rat liver aminoacyl transferase. II. PMID- 4333441 TI - Neonatal smiling in REM states, IV. Premature study. PMID- 4333442 TI - [Results of surgical treatment of deformities due to rickets]. PMID- 4333443 TI - [Tumors of the foot]. PMID- 4333444 TI - The antigenicity of multivalent vaccines for bovine respiratory disease. PMID- 4333445 TI - Isolation of heart-resistant Clostridium Perfringens from healthy cattle. PMID- 4333446 TI - Response of bovine viruses to interferon. PMID- 4333447 TI - [Malignant degeneration of glomus tumor of unusual localization]. PMID- 4333448 TI - [Cytoenzymatic studies of rat myocardium following administration of potassium chloride]. PMID- 4333449 TI - Nuclear magnetic resonance and cytometric studies on mucus from single cervical glands. PMID- 4333450 TI - Preparation and properties of reduced -nicotinamide-adenine-dinucleotide. PMID- 4333451 TI - Benzypyrene hydroxylase activity in isolated parenchymal and nonparenchymal cells of rat liver. AB - Previous studies have implicated the reticuloendothelial cells of the liver in certain aspects of steroid metabolism. The similarity in the metabolism of steroids and polycyclic hydrocarbons suggested that the nonparenchymal cells possibly play a role in these areas. The present study presents evidence that at least one of the microsomal NADPH-requirig enzymes, benzpyrene hydroxylase, is present in nonparenchymal cells and, furthermore, is "inducible." In adult rats treated with 3-methylcholanthrene or beta-naphthoflavone, the nonparenchymal cells exhibited increases in benzpyrene hydroxylase activity of 17-fold and five fold, respectively. Treatment with phenobarbital resulted in only a slight increase in enzyme activity. Enzyme activity in parenchymal cells under similar conditions was increased sixfold and fivefold by 3-methylcholanthrene and beta naphthoflavone, respectively, but not by phenobarbital. PMID- 4333452 TI - Degenerative changes in the mitochondria of flight muscle from aging blowflies. AB - Mitochondria from flight muscle of aging blowflies, Phormia regina, were examined morphologically and biochemically with the electron microscope. An age-dependent degeneration of the mitochondria that is characterized, in part, by the reorganization of the inner membrane into myelin-like whorls has been found. The concentric rings increase in size and number, eventually replacing the normal cristal conformation. Glycogen rosettes are frequently seen in the center of the whorl and may represent the intrusion into the mitochondria of the glycogen in the cytoplasmic matrix of the muscle. The degenerating mitochondria are not associated with lysosomal activity, as indicated by the absence of acid phosphatase. An intense acid phosphatase activity is noted, however, in the dyad, comprising elements of the T system and sarcoplasmic reticulurn. Cytochrome oxidase is active in the ultrastructurally intact portion of the mitochondrion but activity is not evident in that part of the mitochondrion that has undergone morphological change. Thus, the ultrastructural degradation of the mitochondria is correlated with a decrease in biochemical function. This suggests a correspondence between a decrease in the bioenergetic capacity of the flight muscle and a decline in the ability of the aged insect to fly. PMID- 4333453 TI - Secretion of acid hydrolases and its intracellular source in Tetrahymena pyriformis. AB - Axenic Tetrahymena pyriformis, syngen 1, mating type II cells were grown in Cox's defined medium. When washed and transferred into nonnutrient dilute salt solution or resuspended in the defined medium, the intact cells secrete acid hydrolases into the medium. Cells starving in the salt solution release in 5 hr about two thirds of their beta-glucosidase, beta-N-acetylglucosaminidase, alpha glucosidase, and amylase activities, about one-third of their deoxyribonuclease and phosphatase activities, smaller amounts of ribonuclease, and only a negligible fraction of their proteinase activity and protein content. During this period there is practically no change in the enzyme activities (except for a sudden increase of ribonuclease activity) and protein content of cells and medium together. Cells resuspended in the nutrient medium secrete enzymes as do the starved cells, but replace this loss, so that there is a continuous increase of the activities in the total system. According to isopycnic centrifugation experiments performed in sucrose gradients, the source of the hydrolases is a special population of lysosomes which disappear from the cells during starvation. This population equilibrates in the high density region of the gradients and contains the various acid hydrolases in about the proportion in which these enzymes appear in the medium. PMID- 4333454 TI - Demonstration of an ATPase at the cell surface of intact normal and neoplastic human cells in culture. PMID- 4333455 TI - Mammalian cell fusion. IV. Regulation of chromosome formation from interphase nuclei by various chemical compounds. PMID- 4333456 TI - Innervation and acetylcholine sensitivity of skeletal muscle cells differentiated in vitro from chick embryo. PMID- 4333457 TI - Cultures from adult rat liver cells. I. Establishment of monolayer cell-cultures from normal liver. PMID- 4333458 TI - Properties of the mouse embryo conditioned medium factor(s) stimulationg colony formation by mouse bone marrow cells grown in vitro. PMID- 4333459 TI - Scans in children with renal tumors. PMID- 4333460 TI - Wilms tumor at lower end of the ureter extending to the bladder: case report. PMID- 4333461 TI - Influence of neonatal thymectomy on the development of primary Rous sarcomas in two inbred strains of rats. PMID- 4333462 TI - Cyclic AMP and platelet function. PMID- 4333464 TI - [Radiological diagnosis of ulcerating cancer of the stomach]. PMID- 4333465 TI - [2 remarkable forms of bronchial cancer]. PMID- 4333466 TI - ESR studies of irradiated cellulose acetate. PMID- 4333467 TI - [Treatment of trophoblastic tumors]. PMID- 4333468 TI - Primary cancer of the liver: a review of 25 cases and report of two prolonged survivals. PMID- 4333469 TI - Progressive myoclonus with epilepsy. PMID- 4333470 TI - A technique for the assay of 17-hydroxyprogesterone (17-hydroxy-4-pregnene-3,20 dione) in serum using celite column chromatography and competitive protein binding. PMID- 4333471 TI - Myoepithelial nexus. Intercellular membrane fusions in the dilator pupillae muscle. PMID- 4333473 TI - [Polymyositis and virus]. PMID- 4333472 TI - Hypothalamic control of pituitary function in submammalian vertebraes. PMID- 4333474 TI - [Problems concerning oligodendroglia and myelin sheath]. PMID- 4333475 TI - [Histochemical studies of neuroglial cells]. PMID- 4333476 TI - Structure and function of proteins. PMID- 4333477 TI - [A morphogenic study of postaxial synactyly induced in the rat by hadacidin. II. The limb buds in 12- to 14 day embryos]. PMID- 4333478 TI - [Relation between plasma and urine concentration of fluorescence-positive cortisol equivalents]. PMID- 4333479 TI - Electron microscopic observations on FL cells infected with herpes simplex virus. II. Envelopment. PMID- 4333480 TI - Infection of bromodeoxyuridine resistant HeLa cells with SV40 infectious DNA. PMID- 4333481 TI - Temperature sensitive growth of a herpes type virus isolated from a chicken with Marek's disease. PMID- 4333482 TI - Pulmonary varices. PMID- 4333483 TI - Sebum excretion in acromegaly. AB - The sebum excretion rate (S.E.R.) was measured in 20 patients with acromegaly. Eleven were untreated at the time of the measurement and nine had previously undergone surgical hypophysectomy or had received pituitary irradiation by yttrium-90 or radiotherapy. In five patients the S.E.R. was measured before and after such treatment. The mean S.E.R. in the untreated acromegalics was much greater than in a normal population and decreased significantly after successful pituitary ablation. No significant decrease in mean S.E.R. occurred in the group of patients with a poor clinical response to ablation. The correlations between S.E.R. and log serum growth hormone, plasma 11-hydroxycorticosteroid levels, and heel-pad thickness were significant, but there was no significant correlation between S.E.R. and serum protein-bound iodine levels. This suggests that the changes in S.E.R. were due to pituitary ablation but could not necessarily be attributed solely to changes in growth hormone, thyroid-stimulating hormone, or adrenocorticotrophic hormone. The association between the clinical state of the acromegaly and the S.E.R. was better than the association between acromegaly and serum growth hormone. We conclude that the S.E.R. is a useful addition to the clinical and endocrinological data used in assessing acromegaly. PMID- 4333484 TI - Neuropathy associated with hepatitis in patients maintained on haemodialysis. AB - During a study of peripheral nerve function in chronic renal failure, 11 patients who were being treated by chronic intermittent haemodialysis developed serum hepatitis. Before the infection there was a trend towards improvement in nerve conduction velocities. A pronounced deterioration in the conduction velocities in motor fibres of peripheral nerves occurred in association with hepatitis. In the months after recovery from the infection there was again a trend towards improvement in conduction velocities. We suggest that this reflects the occurrence of a peripheral neuropathy which is at least in part demyelinating. The neuropathy is related to the serum hepatitis, but its pathogenesis is indeterminate. PMID- 4333485 TI - Spontaneous hypoglycaemia. PMID- 4333486 TI - Cytopathic effect in cell cultures of rinderpest virus and some other viruses causing rinderpest-like diseases. PMID- 4333487 TI - Identification of bluetongue in U.A.R. (Egypt). A progress report. PMID- 4333488 TI - Hepatocellular carcinoma associated with abdominal fat necrosis in an Ayrshire cow. PMID- 4333489 TI - Observations on foot-and-mouth disease type SAT 2 in Tanzania. August 1968 to August 1969. PMID- 4333490 TI - An evaluation of three agents for eluting adsorbed enterovirus from millipore membrane filters. PMID- 4333491 TI - Purification and characteristics of the enterotoxin of Clostridium perfringens type A. PMID- 4333492 TI - Rapid detection of Clostridium perfringens enterotoxin by a modified ligated intestinal loop technique in rabbits. PMID- 4333493 TI - Detection of virus-associated antigen on membranes of cells productively infected with Marek's disease herpesvirus. PMID- 4333494 TI - The clinical pharmacology of 5-trifluoromethyl-2'-deoxyuridine. PMID- 4333495 TI - Fetal-type isoenzymes in hepatic and nonhepatic rat tumors. PMID- 4333496 TI - Altered regulation of the transport of RNA from nucleus to cytoplasm in rat hepatoma cells. PMID- 4333497 TI - Immunobiological studies of tumors induced by murine sarcoma virus (Kirsten). PMID- 4333498 TI - Effect of transient immunosuppression on host response to neonatally introduced oncogenic virus. PMID- 4333499 TI - Repair mechanism in Sendai virus carrying HeLa cells after damage by 4 hydroxyaminoquinoline 1-oxide. PMID- 4333500 TI - [So-called "innocent" telesystolic murmurs. Diagnostic value of the phonopharmacodynamic method. Review of literature and illustration of a case studied also with left ventriculography]. PMID- 4333501 TI - Estimation of angiotensin II concentration in human plasma by radioimmunoassay. Some applications to physiological and clinical states. PMID- 4333502 TI - ADH levels during salt depletion in dogs. PMID- 4333503 TI - Comparative study of RSV rescue from RSV-transformed mammalian cells. PMID- 4333504 TI - Effects of ionizing radiation on dried spores of Osmunda regalis. I. Electron spin resonance study of spores. PMID- 4333505 TI - Cryosurgery of SV40 prostatic transplant tumors: tumor control, biochemical correlates and immunity. PMID- 4333506 TI - [Intracytoplasmic membrane structures in clostridium perfringens]. PMID- 4333507 TI - [Comparative study of the electron paramagnetic resonance spectra of tumor tissues and nitrosyl complexes of hemoproteins]. PMID- 4333508 TI - Feedback interactions in the control of citric acid cycle activity in rat heart mitochondria. PMID- 4333509 TI - Resolution and reconstitution of the mitochondrial electron transport system. 3. Order of reconstitution and requirement for a new factor for respiration. PMID- 4333510 TI - 7-Deazanebularin. Metabolism in cultures of mouse fibroblasts and incorporation into cellular and viral nucleic acids. PMID- 4333511 TI - Cyclic adenosine monophosphate-stimulated transport of amino acids in kidney cortex. PMID- 4333512 TI - Studies on the dissociation of flavin adenine dinucleotide from metalloflavoproteins. PMID- 4333513 TI - Effects of acetylcholine on labeling of phosphatidate and phosphoinositides by ( 32 P) orthophosphate in nerve ending fractions of guinea pig cortex. PMID- 4333514 TI - The management of nicotinamide and nicotinic acid in the mouse. PMID- 4333515 TI - Requirement of an Escherichia coli 50 S ribosomal protein component for effective interaction of the ribosome with T and G factors and with guanosine triphosphate. PMID- 4333516 TI - Studies on the structure and mechanism of action of the malate-lactate transhydrogenase. PMID- 4333518 TI - Isotope exchange studies on liver alcohol dehydrogenase with cyclohexanol and cyclohexanone as reactants. PMID- 4333519 TI - Lipids of Sendai virus and changes in cellular phospholipid synthesis caused by infection. PMID- 4333517 TI - Salt-induced activation of transfer ribonucleic acid in the formation of lysyl transfer ribonucleic acid by a system from yeast. PMID- 4333520 TI - [Incidence of valvular cardiopathies secondary to rheumatic infection in relation to the therapy adopted. Follow-up study of 148 patients for 2 to 8 years]. PMID- 4333522 TI - [Arterial stenoses with special reference to spasm]. PMID- 4333523 TI - [Diagnostic value of the angiographic magnification technic with finest focus tubes in 2 levels]. PMID- 4333524 TI - Local metabolic rate and left ventricular oxygen consumption in the intact dog heart. PMID- 4333525 TI - Prolonged measurement of 133 Xenon disappearance from subcutaneous tissue of the foot. PMID- 4333526 TI - [The structure of the replicative form of encephlomycarditis virus RNA]. PMID- 4333527 TI - Polysaccharides of the Taenia hydatigena cyst membrane. PMID- 4333529 TI - The temperature dependence of radiation-induced free-radical destruction. PMID- 4333530 TI - Intraoral minor salivary gland tumors. (Report of 34 cases). PMID- 4333531 TI - Biochemical observations on adult Nippostrongylus brasiliensis. PMID- 4333532 TI - Ultrastructure of the tegument and associated structures of Aspidogaster conchicola (Trematoda: Aspidogastrea). PMID- 4333533 TI - An ultrastructural and cytochemical study of metacercarial cyst development in Ascocotyle pachycystis Schroeder and Leigh, 1965. PMID- 4333534 TI - Relation of tegumentary phosphohydrolase and sugar transport in Hymenolepis diminuta. PMID- 4333535 TI - Cytological studies on the absorptive surfaces of cestodes. V. Incorporation of carbohydrate-containing macromolecules into tegument membranes. PMID- 4333528 TI - Diarrhoea: mechanisms and treatment. PMID- 4333536 TI - An ultrasturctural study of the trypanosomatid, Phytomonas elmassiani, from the milkweed, Asclepias syriaca. PMID- 4333537 TI - Immunological relationships of reverse transcriptases from ribonucleic acid tumor viruses. AB - Antiserum to partially purified reverse transcriptase from the Schmidt-Ruppin strain of Rous sarcoma virus has been prepared and characterized. Antibody to the avian polymerase inhibited the reverse transcriptase activity of avian C-type viruses but had no effect on the polymerase activity from C-type viruses of other classes. The known mammalian C-type viral polymerases were significantly inhibited only by the antiserum to murine C-type viral polymerases; reverse transcriptases from four other mammalian viruses were immunologically distinct from both avian and mammalian C-type viral polymerases. Partially purified murine leukemia viral DNA polymerase activity was comparably reduced by specific antibody regardless of the template used for enzyme detection. PMID- 4333538 TI - RNA-dependent DNA polymerase activity of RNA tumor viruses. I. Directing influence of DNA in the reaction. AB - The template requirements and deoxyribonucleic acid (DNA) products of the DNA polymerases isolated from Rauscher leukemia and avian myeloblastosis viruses have been examined. All DNA preparations or synthetic polydeoxynucleotides which are active as primers possess a duplex structure containing single-stranded regions with a 3'-hydroxyl terminus. Native DNA and fully single-stranded DNA are inactive; moreover, their activity is not enhanced by sonic oscillation or treatment with micrococcal nuclease, Neurospora nuclease, or low levels of deoxyribonuclease I. Poor DNA templates are activated by treatment with exonuclease III, large amounts of deoxyribonuclease I, or an endonuclease isolated from Rauscher viral preparations. In reactions primed with deoxyadenylate-deoxythymidylate copolymer, the product formed is covalently attached to primer strands, indicating that no new strands are initiated. DNA polymerase products formed with exonuclease III- or deoxyribonuclase I-treated DNA are duplex structures. Short single-stranded regions are completely filled in, whereas long single-stranded regions are only partly repaired. DNA preparations containing extensive single-stranded regions are poorly utilized as templates. PMID- 4333540 TI - Genetic location of a mutant of bacteriophage T4 deficient in the ability to induce endonuclease II. AB - Reciprocal three-factor crosses and the use of a partial revertant of a putative ribonucleotide reductase mutant of Escherichia coli B/5 as indicator have made it possible to map denA (deficient in endonuclease II) between nrd-11 (ribonucleotide reductase gene B) and amM69 (gene 63) on the bacteriophage T4 chromosome. PMID- 4333539 TI - RNA-dependent DNA polymerase activity of RNA tumor viruses. II. Directing influence of RNA in the reaction. AB - The role of ribonucleic acid (RNA) in deoxyribonucleic acid (DNA) synthesis with the purified DNA polymerase from the avian myeloblastosis virus has been studied. The polymerase catalyzes the synthesis of DNA in the presence of four deoxynucleoside triphosphates, Mg(2+), and a variety of RNA templates including those isolated from avian myeloblastosis, Rous sarcoma, and Rauscher leukemia viruses; phages f2, MS2, and Qbeta; and synthetic homopolymers such as polyadenylate.polyuridylic acid. The enzyme does not initiate the synthesis of new chains but incorporates deoxynucleotides at 3' hydroxyl ends of primer strands. The product is an RNA.DNA hybrid in which the two polynucleotide components are covalently linked. Free DNA has not been detected among the products formed with the purified enzyme in vitro. The DNA synthesized with avian myeloblastosis virus RNA after alkaline hydrolysis has a sedimentation coefficient of 6 to 7S. PMID- 4333541 TI - Identification of virus-induced proteins in cells productively infected with simian virus 40. AB - The number and molecular weight of the structural polypeptides of highly purified simian virus 40 (SV40) were determined by polyacrylamide gel electrophoresis. Six different polypeptides were found, two of which (VP1 and VP2) comprise the bulk of the viral capsid proteins. The pattern of protein synthesis in productively infected CV-1 cells was studied by sodium dodecyl sulfate polyacrylamide gel electrophoresis. Identification of virus-induced proteins in the infected CV-1 cells was achieved in double-labeling experiments by electrophoresis with purified labeled SV40 capsid proteins. Four of these proteins (VP1 and VP4) could be classified as components of the virion because their synthesis occurred after the onset of viral deoxyribonucleic acid (DNA) replication and because they were inhibited by arabinofuranosylcytosine (ara-C). Appearance of two other virus induced proteins was not prevented by ara-C; one of them did not comigrate in the electrophoresis with purified virion polypeptides, and both could be detected before the onset of viral DNA synthesis. These latter two proteins were classified on the basis of these criteria as nonvirion capsid proteins (NCVP1 and NCVP2). PMID- 4333542 TI - Virus-induced interference in heterologously infected HeLa cells. AB - In doubly infected HeLa cells, poliovirus type 1 rapidly and completely dominates vesicular stomatitis virus (VSV) plaque-forming unit production. Poliovirus type 1 shuts off incorporation of amino acids into VSV-specific proteins within 2 hr after superinfection of cells already committed to massive synthesis of VSV proteins. However, poliovirus type 1 appears to have little, if any, direct effect upon incorporation of uridine into VSV-directed ribonucleic acid (RNA) synthesis. Poliovirus apparently interferes with VSV virion production only at the level of translation of viral messenger RNA, although it interferes with host cell macromolecular syntheses at the levels of translation and transcription. PMID- 4333543 TI - Early interaction of rhinoviruses with host cells. AB - The rate of attachment of type 2 virions to suspensions of HeLa cells is much greater than that of type 14, but the number of receptor sites per cell is similar for each type. The receptor sites may be partly saturated with excess virions; attachment is greatly reduced after about 10(4) particles have been taken up per cell. A lack of saturation of type 14 receptors by excess type 2 indicates that their receptor sites are separate on the cell surface. Excess of type 2 blocks attachment of type 1A, however, and excess of type 14 blocks type 51. Attachment of the human rhinoviruses is temperature-dependent with a Q(10) of 2.7. The eclipse reaction is also temperature-dependent. At 34.5 C, the irreversible eclipse of cell-associated rhinovirus type 2 requires only a few minutes, whereas the rate of eclipse of cell-associated type 14 is considerably slower. The eclipse product of type 2 rhinovirus has been recovered from infected cells. It sediments at about 90% of the rate of the infective virions and is missing virus polypeptide 4 (the smallest of the capsid polypeptides). Upon being subjected to CsCl gradient centrifugation, virus polypeptide 2 is also lost but the product still contains ribonucleic acid and bands at about 1.45 g/cc. PMID- 4333544 TI - Synthesis and assembly of simian virus 40. I. Differential synthesis of intact virions and empty shells. AB - Intact virions and empty shells of simian virus 40 may be rapidly separated from each other and from cell contaminants by a procedure employing a CsCl cushion. This approach permits quantitation of their respective syntheses in infected cells labeled with radioactive amino acids. As much as 5 to 10% of the total acid precipitable radioactive lysine in infected cell extracts was incorporated into viral particles in a two-hour pulse late in infection. Evidence for multiple origins of empty shells is presented. Some of the empty shells result from breakdown of intact virions. However, empty shells can also form independently of intact virions. First, labeling for periods of 15 min to 2 hr late in the course of infection results in preferential incorporation of (3)H-lysine into empty shells. Secondly, treatment with the deoxyribonucleic acid inhibitor cytosine beta-d-arabinofuranoside late in infection results in a 50% inhibition in the rate of formation of intact virions with minimal reduction in the rate of appearance of empty shells. PMID- 4333545 TI - Synthesis and assembly of simian virus 40. II. Synthesis of the major capsid protein and its incorporation into viral particles. AB - African green monkey kidney cells infected by simian virus 40 were analyzed for the presence of the major capsid protein (capsid protein I) by immunological and radiolabeling techniques. Antisera with different specificities were prepared by immunization with intact or denatured viral particles. Antisera prepared against intact virus reacted by complement fixation with viral particles and with an 8S subunit containing the capsid protein I. Antisera prepared against denatured viral particles reacted with unassembled capsid protein(s) as well as with viral particles. These antisera were used to detect 8S viral subunits or unassembled viral capsid protein in soluble extracts of infected cells after centrifugation at 100,000 x g to remove viral particles. The soluble antigen pool was found to be small during infection with wild-type virus or a temperature-sensitive mutant deficient in the synthesis of viral particles. Pulse-chase experiments, performed at a high multiplicity of infection, also indicated a small pool of nonparticle capsid protein I. Radioactive lysine was incorporated into capsid protein I of virus particles during a 2-hr pulse. A subsequent chase with excess unlabeled lysine resulted in only a slight increase in the radio-activity found in capsid protein I of viral particles. Furthermore, in the same experiments, capsid protein I was incorporated preferentially into empty shells during the pulse with a shift in radioactivity to intact virions during the chase period, indicating a possible precursor relationship between the two types of virus particles. PMID- 4333546 TI - Inhibition of protein synthesis in L cells infected with vesicular stomatitis virus. AB - The inhibition of protein synthesis in L cells by vesicular stomatitis virus (VSV) requires the synthesis of new protein subsequent to virus infection. However, two mechanisms may be involved in the inhibition of cell protein synthesis by VSV: an initial, multiplicity-dependent, ultraviolet-insensitive inhibition and a progressive, ultraviolet-sensitive inhibition. PMID- 4333549 TI - [Determination of alpha 1-fetoprotein]. PMID- 4333548 TI - [31 cases with anaerobic bacteria as the only isolates]. PMID- 4333547 TI - Immunoelectrophoretic analysis of avian ribonucleic acid tumor virus group specific antigens. AB - Tumors induced in pigeons by inoculation with the Schmidt-Ruppin strain of Rous sarcoma virus regressed after about 6 weeks. Sera from these pigeons, taken 8 weeks after inoculation, had complement-fixing group-specific antibody titers of 1:2 to 1:256. In immunoelectrophoresis with the pigeon serum, disrupted BAI strain A (myeloblastosis) avian tumor virus showed at least five precipitin arcs. The pattern of precipitin lines was dependent in part on the means used for virus disruption, and ethyl ether and nonionic detergents appeared to be both effective and relatively mild reagents. Immunoelectrophoretic comparison of pigeon serum with serum from a tumor-bearing hamster and that from virus-inoculated rabbits yielded similar, though not identical, results. PMID- 4333550 TI - [Significance of quantitative analysis of alpha 1-fetoglobulin]. PMID- 4333551 TI - [Diagnosis of hepatoma by alpha-fetoprotein]. PMID- 4333552 TI - [Purification and radioimmunoassay of alpha 1-fetoprotein]. PMID- 4333553 TI - [Fluctuation of serum alpha-fetoglobulin in newborn infants]. PMID- 4333554 TI - [Direct determination of total serum cholesterol with ethyl acetate and iron perchlorate]. PMID- 4333555 TI - [Changes with time following addition of the color reagent in LDH determination]. PMID- 4333556 TI - [Simultaneous quantitative measurement of blood alpha-ketoglutaric acid and pyruvic acid]. PMID- 4333557 TI - [Quantitative analysis of plasma pyruvic acid by the enzyme method]. PMID- 4333558 TI - [Evaluation of GOT determination by NADH reduction method, with special reference to application of Vicker's auto-analyser]. PMID- 4333559 TI - [Detection of Australia antigen by single radial diffusion method]. PMID- 4333560 TI - [The pros and cons of luminal teatment of hyperbilirubinemia]. PMID- 4333562 TI - DPNH-methemoglobin reductase deficiency and hereditary methemoglobinemia. PMID- 4333561 TI - [Primary cancer of the liver associated with Australian antigen]. PMID- 4333563 TI - Clinical liver transplantation. PMID- 4333564 TI - Virus DNA and host DNA in polyoma virus-infected cells at high temperature. PMID- 4333565 TI - Synchronization of Rous sarcoma virus production in chick embryo cells. PMID- 4333566 TI - The altered patterns of transfer RNA in SV40-infected and transformed cells. PMID- 4333567 TI - Properties of mouse leukemia viruses. I. Characterization of various antisera and serological identification of viral components. PMID- 4333569 TI - Detection of some murine leukemia virus antigens in virus particles derived from 3T3 cells transformed only by murine sarcoma virus. PMID- 4333568 TI - Structural proteins of Rauscher leukemia virus and Harvey sarcoma virus. PMID- 4333570 TI - Unusual molecular size of RNA from a long-rod mutant of vesicular stomatitis virus. PMID- 4333571 TI - Early stimulation of DNA synthesis in chicken fibroblasts infected by avian myeloblastosis virus. PMID- 4333572 TI - Detection and assay of feline leukemia virus (FeLV) by a mixed-culture cytopathogenicity method. PMID- 4333573 TI - Avian reticuloendotheliosis virus (strain T): V. DNA polymerase. PMID- 4333574 TI - Depression of macromolecular synthesis in cells infected with guanidine-dependent poliovirus under restrictive conditions. PMID- 4333575 TI - Chemical and enzymatic characteristics of cytoplasmic membranes of poliovirus infected HeLa cells. PMID- 4333576 TI - Incorporation of lipid precursors into cytoplasmic membranes of poliovirus infected HeLa cells. PMID- 4333577 TI - The influence of benzquinamide, oxypertine and prenylamine on monoamine levels and on monoamine effects in the spinal cord. PMID- 4333578 TI - Respiratory capacity of white, red, and intermediate muscle: adaptative response to exercise. PMID- 4333580 TI - Age-related changes of cardiac performance in male rats. PMID- 4333579 TI - Amino acid incorporation into myocardium: effect of insulin, glucagon, and dibutyryl 3',5'-AMP. PMID- 4333581 TI - Sympathoadrenal regulation of the cardiovascular system in the baboon. PMID- 4333582 TI - The role of the RES in shock states. PMID- 4333583 TI - [Influence of furosemide on the effect of sympathomimetic amines and angiotensin on the arterial pressure of rabbits]. PMID- 4333584 TI - Purification and properties of ATP-sulfurylase from Furth mouse mastocytoma. PMID- 4333585 TI - Comparative studies of the responses of rat liver microsomal glucose-6 phosphatase and inorganic pyrophosphate-glucose phosphotransferase to phospholipase C treatment and phospholipid supplementation. PMID- 4333586 TI - Isolation of phosphodiesterase from sugar beet leaves. PMID- 4333587 TI - Some aspects of the specificity and action pattern of -I,3-glucan glucanohydrolase from Spisula sachalinensis. PMID- 4333588 TI - Characterization of a collagenase from rat skin. PMID- 4333590 TI - Lysyl tRNA synthetase of Escherichia coli B: formation and reactions of ATP enzyme and lysyl-AMP-enzyme complexes. PMID- 4333589 TI - Purification and properties of an enzyme from cell suspension cultures of parsley catalyzing the synthesis of UDP-apiose and UDP-D-xylose from UDP-D-glucuronic acid. PMID- 4333591 TI - The action of collagen on an inorganic pyrophosphatase in blood platelets. PMID- 4333592 TI - The actions of hydroxymethylhydroperoxide and bis(hydroxymethyl)peroxide on fumarate hydratase, lactate dehydrogenase, aspartate aminotransferase, glucose oxidase, and acid phosphatase. PMID- 4333593 TI - Glycogenolytic activity in the liver of the human foetus. PMID- 4333594 TI - [Short-latency auditory evoked potentials at the retroauricular region]. PMID- 4333595 TI - [Verner-Morrison syndrome (pancreatic cholera, WDHA-syndrome). Clinical report on 4 cases]. PMID- 4333597 TI - Studies of angiotensin-II conformations by circular dichroism. PMID- 4333596 TI - [Selection of chemotherapeutic agents for the resistance determination of fast growing bacteria (minimal requirements)]. PMID- 4333598 TI - Maleimide and isomaleimide pyrrolidine-nitroxide spin labels. PMID- 4333599 TI - Substrate properties of yeast tRNA Phe oxidized and reduced at the 3'-terminal ribose. PMID- 4333600 TI - Relationship between the binding of pyrophosphate by myosin and the protection of its active centre. PMID- 4333601 TI - The covalently-bound flavin of hepatic monoamine oxidase. 1. Isolation and sequence of a flavin peptide and evidence for binding at the 8alpha position. PMID- 4333602 TI - The covalently-bound flavin of hepatic monoamine oxidase. 2. Identification and properties of cysteinyl riboflavin. PMID- 4333603 TI - Studies of glutamate dehydrogenase. The mechanism of the association-dissociation equilibrium of beef-liver glutamate dehydrogenase. PMID- 4333604 TI - [Histochemical studies on the activity of some hydroxisteroid dehydrogenases in the developing guinea-pig placenta]. PMID- 4333605 TI - Role of histidine transfer ribonucleic acid in regulation of synthesis of histidyl-transfer ribonucleic acid synthetase of Salmonella typhimurium. AB - The role of histidine transfer ribonucleic acid (tRNA) in repression of synthesis of histidyl-tRNA synthetase was examined in two strains of Salmonella typhimurium, one of which was a histidine tRNA (hisR) mutant possessing 52% of the wild-type (hisR(+)) histidine tRNA and a derepressed level of the histidine biosynthetic enzymes during histidine-unrestricted growth. Histidine-restricted growth caused a derepression of the rate of formation of histidyl-tRNA synthetase in both strains. In the case of the wild-type strain, addition of histidine to the derepressed culture caused a repression of synthesis of histidyl-tRNA synthetase for at least one generation of growth. In contrast, when histidine was restored to the derepressed hisR mutant culture, synthesis of histidyl-tRNA synthetase was continued at the initial derepressed rate. These results suggest that histidine must be attached to histidine tRNA for repression of synthesis of histidyl-tRNA synthetase. PMID- 4333606 TI - Leakage of periplasmic enzymes by mutants of Escherichia coli and Salmonella typhimurium: isolation of "periplasmic leaky" mutants. AB - Mutants of Escherichia coli and Salmonella typhimurium were selected on the basis of their spontaneous leakage of ribonuclease I. The mutants also leaked several other periplasmic enzymes into the medium during active growth but did not leak the intracellular enzymes glucose-6-phosphate dehydrogenase or phosphoglucose isomerase. PMID- 4333607 TI - Germination of heat- and alkali-altered spores of Clostridium perfringens type A by lysozyme and an initiation protein. AB - The normal system functioning in the utilization of metabolizable germinants by both heat-sensitive and heat-resistant spores of Clostridium perfringens was inactivated by heat or by treatment of the spores with alkali to remove a soluble coat protein layer. Altered spores were incapable of germination (less than 1%) and outgrowth (less than 0.0005%) in complex media without the addition of either lysozyme or an initiation protein produced by C. perfringens. The addition of either of these agents permitted, in the case of alkali-treated spores, both 90 to 95% germination and outgrowth, as measured by colony formation. In the case of heat-damaged spores, only 50% germination and 2% outgrowth resulted from addition of the initiation protein, whereas lysozyme permitted 85% germination and 8% outgrowth. Alteration of the spores by heat or alkali apparently inactivated the normal lytic system responsible for cortical degradation during germination. Kinetics of production of the initiation protein and conditions affecting both its activity and that of lysozyme on altered spores are described. PMID- 4333608 TI - Identification of competence-repressing factors during log-phase growth of Haemophilus influenzae. AB - Metabolic factors that suppress development of competence in Haemophilus influenzae during growth in the synthetic medium MI(c) have been identified. These include inosine, nicotinamide adenine dinucleotide, glycerol, and uracil. It is also possible to initiate competence in the presence of these substances if the oxygen tension in the culture is temporarily reduced. PMID- 4333609 TI - Localization and solubilization of the respiratory nitrate reductase of Bacillus stearothermophilus. AB - Membranes were isolated from Bacillus stearothermophilus 2184D by lysozyme digestion of the cell wall and subsequent differential centrifugation. Observations with the electron microscope indicate that such membranes are relatively intact and have a typical membrane appearance. Nitrate will preferentially oxidize the cytochrome b of such membranes. Approximately 80% of the total respiratory nitrate reductase activity of whole cells can be localized in the washed membrane fraction and the process of membrane isolation results in a sixfold purification of this enzyme. Of several detergents tested, sodium dodecyl sulfate, Triton 114, and Triton X-100 are most effective in converting reduced methyl viologen-nitrate reductase to a form which will not pellet at 130,000 x g. Density gradient analysis reveals that such detergent-mediated solubilization converts virtually all membrane protein to a form of lighter density. PMID- 4333610 TI - Physical aggregation and functional reconstitution of solubilized membranes of Bacillus stearothermophilus. AB - Isolated membranes of Bacillus stearothermophilus 2184D can be disrupted by treatment with sodium dodecyl sulfate (SDS). This disruption is attended by a decreased turbidity of membrane suspensions and a differential loss of activities of the electron transport system. Reduced methyl viologen (MVH)-nitrate reductase activity is insensitive to SDS treatment, whereas reduced nicotinamide adenine dinucleotide (NADH)-nitrate reductase and cyanide-sensitive NADH oxidase activities are decreased by 80% at an SDS concentration of 0.5 mg/mg of membrane protein. NADH-menadione reductase activity is unaffected at this SDS concentration, but at higher detergent levels it also decreases in activity. The abilities of NADH to reduce and nitrate to oxidize the cytochrome components of the membrane were also decreased after SDS treatment. Dilution of solubilized membrane in buffer containing divalent cation results in formation of an aggregate with an increased turbidity and reconstituted NADH-nitrate reductase and cyanide-sensitive NADH oxidase activities. Of several cations tested, magnesium was the most effective, and the reconstitution process was pH-dependent with an optimum at pH 7.4. Intact and aggregated membranes had similar densities and cytochrome contents, and the sensitivity of NADH-nitrate reductase to several inhibitors was similar in intact and reconstituted membranes. PMID- 4333611 TI - Transmission and spread of embryonic induction. I. Temporal relationships in transfilter induction of kidney tubules in vitro. PMID- 4333613 TI - A buoyant method for the determination of the superhelix density of closed circular DNA. PMID- 4333612 TI - Fluorometric studies of oxidative metabolism in isolated papillary muscle of the rabbit. AB - The fluorometric technique for measuring the levels of reduced pyridine nucleotides was used to study oxidative metabolism in isolated rabbit papillary muscle at 23 degrees C. The 100% standard level of tissue fluorescence was defined as that measured for muscles resting in oxygenated 10 mM pyruvate solution. This level increased 15% with anoxia and decreased 45% with stimulation in substrate-free solution. Thus, about one-half of the standard tissue fluorescence was metabolically labile and this labile fraction is suggested to be mitochondrial in origin. Decreased tissue fluorescence following mechanical activity was identified with increased oxidation of mitochondrial reduced nicotinamide adenine dinucleotide (NADH) owing to stimulation by adenosine diphosphate (ADP), released during activity, of mitochondrial respiration. The kinetics of the fluorescence transients were slowed fourfold by removal of pyruvate. This effect was not significantly reversed by addition of 10 mM glucose. The time integrals of the fluorescence transients were linearly related to the amounts of mechanical activity in the presence, but not in the absence, of pyruvate. A positive correlation was observed between the steady-state peak tension at constant stimulus rate and the resting level of reduction of pyridine nucleotides in various media. The fluorometric results are interpreted to be indicative of the steady and transient states established by the substrate dehydrogenases and the respiratory chain during oxidative phosphorylation in mitochondria. PMID- 4333614 TI - Sedimentation velocity behavior of closed circular SV40 DNA as a function of superhelix density, ionic strength, counterion and temperature. PMID- 4333616 TI - Evaluation of 1-methyl-2-(4'-fluorophenyl)-5-nitroimidazole. PMID- 4333615 TI - Hepatic amoebiasis in Ceylon. PMID- 4333618 TI - Technique of polytomography in otology. PMID- 4333617 TI - Dysfunction of carbohydrate metabolism as an element in the set of factors resulting in the polysaccharide nose and nasal polyps (the polysaccharide nose). PMID- 4333620 TI - [Present problems in prostatic carcinoma]. PMID- 4333619 TI - The submaxillary gland as a site of distant metastasis. PMID- 4333621 TI - [Isolation of Myxovirus parainfluenza 3 from cattle in the State of Sao Paulo, Brazil]. PMID- 4333622 TI - [Intratypic serological identification of poliovirus by the method of comparison of neutralization indices]. PMID- 4333623 TI - [Results of virological studies in acute herpetic stomatitis in children]. PMID- 4333624 TI - [Histological structure of breast neoplasms and sex chromatin content]. PMID- 4333625 TI - [Antibody formation during experimental hepatocarcinogenesis]. PMID- 4333626 TI - [Angiography in diagnosis and treatment of neck chemodectomas]. PMID- 4333628 TI - [Isolation and cultivation of the idiopathic porcine pox virus in testis cell cultures of young pigs]. PMID- 4333627 TI - [Sertoli-type androblastoma of the ovary]. PMID- 4333629 TI - [A historical observation on oral and dental care]. PMID- 4333630 TI - The ultrastructure of helminth. VI. The body wall of Opisthorchis viverrini (Poirier, 1886). PMID- 4333631 TI - Effect of gluconeogenic diet on primary hepatoma patients. PMID- 4333632 TI - Malignant transformation of human cell in vitro by the SV 40 DNA and related alteration in biological activity of cell membranes. PMID- 4333633 TI - Diagnosis of equine infectious anemia by immunodiffusion test. PMID- 4333634 TI - Hog cholera virus yields in swine kidney cells fused with beta-propiolactone inactivated Sendai virus. PMID- 4333635 TI - Infectious enteritis of turkeys: characterization of two reoviruses isolated by sucrose density gradient centrifugation from turkeys with infectious enteritis. PMID- 4333636 TI - Infectious enteritis of turkeys: pathogenicity of bacteria-free filtrates and a viral agent isolated from turkeys with infectious enteritis. PMID- 4333637 TI - Marek's disease herpesvirus: growth and detection in vivo and in vitro. PMID- 4333638 TI - Experimentally induced infection of in utero bovine fetuses with bovine parainfluenza 3 virus. PMID- 4333639 TI - Bluetongue in sheep and cattle: efficacy of embryonating chicken eggs in viral isolations. PMID- 4333640 TI - Primary ovarian neoplasms in infants and children. A study of 81 cases diagnosed in Finland and Sweden. PMID- 4333641 TI - [Study of the viability and culture properties of Actinomycetes preserved for a long time in a lyophilized state]. PMID- 4333642 TI - [Treatment with ristomycin sulfate of pregnant rats infected with Staphylococci resistant to several antibiotics]. PMID- 4333644 TI - [Combined effect of morphocycline and erythromycin on the pathogenic Clostridia and experimental anaerobic (gaseous) infection]. PMID- 4333643 TI - [Synergistic and antagonistic effect of chemotherapeutic agents on pathogenic Staphylococci]. PMID- 4333645 TI - Cellular communication through membrane junctions. Special consideration of wound healing and cancer. PMID- 4333647 TI - The effect of phenobarbitone-induction on vitamin D metabolism. PMID- 4333646 TI - The role of the third factor in ascites: an experimental approach. PMID- 4333648 TI - Metabolic interrelationships in the red cell. PMID- 4333649 TI - [Virus-like particles in breast tissue in breast carcinoma and chronic cystic mastopathy]. PMID- 4333650 TI - [Water conditioning]. PMID- 4333652 TI - The temperature-dependent enzymatic breakdown of rRNA of reticulocytes. PMID- 4333651 TI - Isolation of a plasma-membrane subfraction from rat liver containing an insulin sensitive cyclic-AMP phosphodiesterase. PMID- 4333654 TI - A myoglobin-type haemoglobin of Chironomus thummi thummi. PMID- 4333653 TI - [Influence of various hormones on formation of adenosine-3':5'-monophosphate and guanosine-3':5'-monophosphate by particulate preparations from rat kidney]. PMID- 4333655 TI - Involvement of adrenergic receptors in central vagus activity. PMID- 4333656 TI - Pharmacological properties of inhibitions in the cerebellar cortex. PMID- 4333659 TI - Lipiodol droplets in cineradiographic quantitation of pulsatile and non-pulsatile blood flow. Model experiments. PMID- 4333657 TI - Plasma-dependent chemotaxis of macrophages towards mycobacterium tuberculosis and other organisms. PMID- 4333658 TI - Angiography after end-to-side portacaval shunt. Clinical, laboratory, and pharmacoangiographic observations. PMID- 4333660 TI - Radiologic assessment of portal vein blood flow. Description of method and application. PMID- 4333661 TI - Insulinomas: medical management as a successful alternative to surgical therapy. PMID- 4333663 TI - Localization of phosphatase activities in the rat anterior pituitary gland. PMID- 4333662 TI - Transport adenosine triphosphatase cytochemistry. I. Biochemical characterization of a cytochemical medium for the ultrastructural localization of ouabain sensitive, potassium-dependent phosphatase activity in the avian salt gland. PMID- 4333665 TI - Epstein-Barr virus in human lymphoblastoid cells: enhancing the percentage of virus-positive cells by cocultivation with African green monkey (Vero) cells. PMID- 4333664 TI - Transport adenosine triphosphatase cytochemistry. II. Cytochemical localization of ouabin-sensitive, potassium-dependent phosphatase activity in the secretory epithelium of the avian salt gland. PMID- 4333666 TI - Blocking of direct membrane immunofluorescence in titration of membrane-reactive antibodies associated with Epstein-Barr virus. PMID- 4333667 TI - Immature particle formation of Yaba poxvirus studied by electron microscopy. PMID- 4333668 TI - Liver and lung tumors in mice exposed at birth to 4-dimethylaminoazobenzene or its 2-methyl or 3'-methyl derivatives. PMID- 4333670 TI - Epitheliomesenchymal interactions in the proliferative response evoked by polyoma virus in odontogenic epithelium in vitro. PMID- 4333669 TI - Tumor-specific antigen solubilized by hypertonic potassium chloride. PMID- 4333671 TI - Amino acids and presynaptic inhibition in the rat cuneate nucleus. AB - 1. Presynaptic inhibition was evoked in the rat cuneate nucleus by a peripheral conditioning stimulus. The dicarboxylic amino acid salts glutamate and aspartate and the neutral amino acids glycine and gamma-aminobutyric acid (GABA) were topically applied to a restricted area of the cuneate nucleus and their effects on both resting primary afferent terminal excitability and the increase in excitability of afferent terminals during presynaptic inhibition determined.2. Aspartate had no effect on either resting primary afferent terminal excitability or on the increase in excitability during presynaptic inhibition.3. Glycine reduced both resting primary afferent terminal excitability and presynaptic inhibition.4. Glutamate increased both resting primary afferent terminal excitability and presynaptic inhibition while GABA increased resting primary afferent terminal excitability but reduced the increase in excitability during presynaptic inhibition.5. The convulsant alkaloids picrotoxin (given intravenously) and bicuculline (topically applied) blocked presynaptic inhibition. The blocking action of picrotoxin was overcome by topical application of GABA but not glutamate.6. Simultaneous measurement of pre- and post-synaptic excitability in the cuneate nucleus showed that while glutamate increased excitability at both sites, GABA increased primary afferent terminal excitability but depressed post-synaptic excitability.7. It is concluded that glycine and glutamate exert non-specific actions on primary afferent terminals similar to their effects at post-synaptic sites elsewhere in the C.N.S. while GABA depolarizes primary afferent terminals by a specific action at the same receptor site as the presynaptic inhibitory transmitter. The possibility is discussed that the presynaptic inhibitory transmitter in the cuneate nucleus is GABA or a closely related substance. PMID- 4333673 TI - Amoebic peritonitis. A study of 73 cases. PMID- 4333674 TI - New amoebicide (MK-910) in treatment of hepatic amoebiasis. PMID- 4333672 TI - The fine structural localization of cholinesterases in the carotid body of the cat. AB - 1. The distribution of cholinesterases in the carotid body of the cat has been investigated with the electron microscope to obtain a clearer picture of the localization of the enzyme. This is of relevance to the possible role of acetylcholine as a transmitter in the carotid body.2. Tissues were fixed for short periods and incubated by the method of Karnovsky for the fine localization of cholinesterases.3. The enzyme was found in two main sites. Butyrylcholinesterase was present on the type II cell membrane while acetylcholinesterase was found in groups of peripheral axons. No intracellular enzyme was found.4. It is concluded that acetylcholine may be a transmitter in the carotid body and that it may be partly destroyed by enzymic hydrolysis. A possible explanation for some of the anomalous pharmacological findings is suggested. PMID- 4333675 TI - Amoebic appendicitis. PMID- 4333676 TI - Multiple amoebic liver abscesses. A study of 56 cases. PMID- 4333677 TI - Pericardial amoebiasis following amoebic liver abscess of the left lobe. PMID- 4333678 TI - [Pleomorphic adenoma or mixed tumor (clinicostatistic and histopathologic study on 192 cases)]. PMID- 4333679 TI - [Dyspnea due to acute respiratory infections]. PMID- 4333680 TI - [Surgical treatment of cancer of the proximal portion of the stomach in the aged]. PMID- 4333681 TI - [Plasma renin activity of the rat in systemic alkalosis and acidosis]. PMID- 4333682 TI - [Differences of indicator distribution in heart muscle between the in vitro- and in vivo-methods used for extracellular space determinations]. PMID- 4333683 TI - [Symptomatic infantile polymyoclonus]. PMID- 4333684 TI - [Results of lymphography in malignant testicular tumors]. PMID- 4333685 TI - [Incisional hernia operations in a large surgical clinic. 2. Successful treatment of severe incisional hernias]. PMID- 4333686 TI - Effects of mutagenic treatment by ethidium bromide on cellular and mitochondrial phenotype. PMID- 4333687 TI - An exchange enzyme-catalyzing incorporation of inorganic phosphate into adenosine diphosphate in Alcaligenes faecalis. PMID- 4333689 TI - Isolated adrenal cells: steroidogenesis and cyclic AMP accumulation in response to ACTH. PMID- 4333688 TI - Aldehyde oxidation in rat liver mitochondria. PMID- 4333690 TI - Interaction of poliovirus-induced double-stranded RNA with HeLa cells. PMID- 4333691 TI - Functional significance of arrangement of neurones in cell assemblies. PMID- 4333692 TI - [Histoenzymatic and histochemical analysis of non-cellular structures of porous human connective tissue during ontogenesis]. PMID- 4333693 TI - [Method for preliminary verification of the results of reactions to several phosphatases in epoxy-embeded tissues for subsequent aimed-ultratome sectioning]. PMID- 4333694 TI - Effect of phentolamine on the increase in brain glycolysis following the intraventricular administration of dibutyryl-3,5-cyclic adenosine monophosphate and sodium fluoride to mice. PMID- 4333695 TI - Production of L-asparagine by tumor cells and the effect of asparagine analogs. PMID- 4333696 TI - Actions of quazodine (MJ1988) on smooth muscle. AB - 1. Quazodine (MJ1988; 6,7-dimethoxy-4-ethyl-quinazoline) relaxed a variety of vascular and extravascular smooth muscle preparations and antagonized, non competitively, several substances which contract smooth muscle.2. This activity was not due to beta-adrenoceptor stimulation or to alpha-adrenoceptor blockade.3. On the rabbit duodenum, the inhibitory effect was qualitatively similar to that of theophylline and was antagonized by the phosphodiesterase potentiator, imidazole.4. The activity of quazodine was similar to, but up to 18 times greater than, that of theophylline and it is suggested that at least part of its activity on vascular and extravascular smooth muscle is due to inhibition of phosphodiesterase. PMID- 4333697 TI - Antibodies to respiratory syncytial virus in a normal community in Chandigarh area, northern India. AB - A survey for the presence of respiratory syncytial (RS) virus antibodies has been carried out in 346 sera from a healthy community in northern India. The results showed that 19.6% of the sera were positive and had a titre of 16 or more. The higher titres were observed more frequently in the younger age groups. There is, therefore, serological evidence for the occurrence of RS virus infection in India. PMID- 4333699 TI - The alveolar macrophage. PMID- 4333698 TI - Lead and the kidney. PMID- 4333700 TI - The anthracotic pneumoconioses. PMID- 4333701 TI - The relationship between the vascular responses to the peptides ranatensin and angiotensin. PMID- 4333702 TI - Modification of spinal transmission by nikethamide. PMID- 4333703 TI - Schistosoma mansoni: cytochemistry of eosinophils in egg-caused early hepatic granulomas of mice. PMID- 4333704 TI - Hospital discharge: by plan or by chance? PMID- 4333706 TI - Quantitative thin-layer chromatography of porphyrins by in situ fluorescence measurements. PMID- 4333705 TI - Adrenergic receptors in the female canine urethra. PMID- 4333707 TI - Thin-layer chromatographic comparison of commercially available silica gel coated films and sheets with silica gel coated glass plates, demonstrated on toxicologically interesting substances. PMID- 4333708 TI - In vitro transformation of primary and continuous rat fibroblasts by Rous sarcoma virus (Schmidt-Ruppin). PMID- 4333709 TI - Interferon response to sendai and rubella viruses in human foetal cultures, leucocytes and placental cultures. PMID- 4333710 TI - Identification of vesicular stomatitis virus nucleoprotein in situ. PMID- 4333711 TI - A quantitative ultrastructural study of the development of bluetongue virus in Madin-Darby bovine kidney cells. PMID- 4333712 TI - Characterization of murine sarcoma virus (Kirsten) transformation of mouse and human cells. PMID- 4333713 TI - Ecidence for linkage between genetic loci controlling response of fowl to subgroup A and subgroup C sarcoma viruses. PMID- 4333714 TI - Physicochemical and morphological relationships of some arthropod-borne viruses to bluetongue virus--a new taxonomic group. Physiocochemical and serological studies. PMID- 4333715 TI - Physicochemical and morphological relationships of some arthropod-borne viruses to bluetongue virus--a new taxonomic group. Electron microscopic studies. PMID- 4333716 TI - Isolation of helper viruses from preparations of hamster-specific sarcoma viruses. PMID- 4333717 TI - Replication of vesicular stomatitis virus: characterization of the virus-induced RNA. PMID- 4333718 TI - Kinetics of synthesis and rate of degradation of T antigen induced by polyoma virus. PMID- 4333719 TI - Temperature-sensitive mutants of herpes simplex virus type 2. PMID- 4333720 TI - [Report of a case of mixed tumor in submaxillary gland]. PMID- 4333721 TI - Demonstration of differences in murine sarcoma virus foci formed in mouse and rat cells under a soft agar overlay. PMID- 4333722 TI - Antigenically distinct forms of mammary tumor virus in blood and mammary tissues of mice. PMID- 4333723 TI - Origin of nuclei in spontaneous HeLa cell chromosome pulverization. PMID- 4333724 TI - Relationship between initiating dose and concentration of Rous sarcoma virus (type O) in tumors of germfree quail. PMID- 4333725 TI - Lymphoid cell-culture line derived from lymph node of marmoset infected wtih Herpesvirus saimiri--preliminary report. PMID- 4333726 TI - Inhibition of pituitary-induced nodular hyperplasia in mammary glands of C3H mice fed a phenylalanine-deficient diet. PMID- 4333727 TI - Eosinophilic membranes of mammary terminal ducts and acini: diagnostic significance of their absence in infiltrating malignant lesions. PMID- 4333728 TI - Excerpts from "Pathology of the breast". PMID- 4333729 TI - Syndrome of profound apathy (akinetic mutism) secondary to thalamic metastasis of unrecognized lung cancer. PMID- 4333730 TI - Pressure palsy of accessory nerve (clinical and electromyographical evaluation after unsuccessful hanging). PMID- 4333731 TI - [Lung neoplasms caused by viruses in men and animal]. PMID- 4333732 TI - The ultrastructure of the intestinal epithelium of Tanqua tiara (Linstow, 1879) (Nematoda: Gnathostomatidae). PMID- 4333733 TI - Lesions in puppies surviving infection with canine herpesvirus. PMID- 4333734 TI - Rate of DNA chain growth in mammalian cells infected with cytocidal RNA viruses. PMID- 4333735 TI - Analysis of the three components of the simian virus 40: pseudo-, mature, and defective viruses. PMID- 4333736 TI - Studies on the antiviral activity and cell interaction of synthetic double stranded polyribo- and polydeoxyribonucleotides. PMID- 4333737 TI - Cell-surface antigens induced by avian RNA tumor viruses: detection by a cytotoxic microassay. PMID- 4333738 TI - Structural proteins of Marek's disease virus. PMID- 4333739 TI - Characteristics of a conditional mutant of Rous sarcoma virus defective in ability to transform cells at high temperature. PMID- 4333740 TI - Exocortis virus: an infectious free-nucleic acid plant virus with unusual properties. PMID- 4333741 TI - Existence and expression of tumor virus genes in chick embryo cells. PMID- 4333742 TI - The a subunit in the RNA of transforming avian tumor viruses. I. Occurrence in different virus strains. II. Spontaneous loss resulting in nontransforming variants. PMID- 4333743 TI - Evidence for transcriptional control of the herpes simplex virus genome in infected human cells. PMID- 4333744 TI - C-type virus particles produced by normal mouse spleen-thymus cultures. PMID- 4333745 TI - Protein kinase associated with RNA tumor viruses and other budding RNA viruses. PMID- 4333746 TI - Clinical study of the preventing effect of xylitol on adrenocortical suppression by steroid therapy. PMID- 4333747 TI - [Electron paramagnetic resonance in polymethyl methacrylate irradiated with Co60]. PMID- 4333748 TI - Quantitative immunofluorescence of EB virus-infected cells. PMID- 4333749 TI - Fluorochrome-labeled anti-immunoglobulin fractions used with stabilized antigen preparations for the assessment of parasitic diseases. PMID- 4333750 TI - Complexity of antigen-antibody systems associated with Epstein-Barr virus. PMID- 4333751 TI - Demonstration of cell-surface antigens on chemically induced tumors. PMID- 4333752 TI - Immunofluorescent detection of human antibodies reactive with tumor. PMID- 4333753 TI - Microfluorimetry in the antigenic analysis of closely related microorganisms. PMID- 4333754 TI - Comparison of immunofluorescent and immunoenzymatic techniques applied to the study of viral antigens. PMID- 4333755 TI - Rapid diagnosis of respiratory virus infection in infected tissue cultures. PMID- 4333756 TI - Collagenolytic-like activity of normal human epidermis. PMID- 4333758 TI - Mannitol biosynthesis in Sclerotinia sclerotiorum. PMID- 4333757 TI - [Langerhans cells in viral warts. Studies on the possible relationship between Langerhans cells and keratinization]. PMID- 4333759 TI - [Experimental cancers of the lung induced in the rat by radon inhalation]. PMID- 4333760 TI - [Concept of the morphological evolution and mechanisms of transmission of mammary cancer virus: attempted generalization]. PMID- 4333762 TI - Adenocystic carcinoma and mucoepidermoid carcinoma of the tracheobronchial tree. PMID- 4333761 TI - Longterm follow-up study of patients with bronchial anastomosis or tracheal replacement. PMID- 4333763 TI - Heavy metals and spermatozoan motility. I. Distribution of iron, zinc and copper in sea urchin spermatozoa. PMID- 4333764 TI - Dissociation of cell motility from cell proliferation in BALB-c-3T3 fibroblasts. PMID- 4333766 TI - Helping the heart patient go back to work. PMID- 4333765 TI - Metabolic changes in human spermatozoa related to capacitation. PMID- 4333767 TI - Tardy paralysis of the ulnar nerve due to traumatic false aneurysm of the ulnar artery: a case report. PMID- 4333768 TI - Ultrastructural survey of primary liver cell carcinomas from Uganda. PMID- 4333769 TI - Human lymphoblastoid cell lines. 3. Co-cultivation technique for establishment of new lines. PMID- 4333770 TI - Influence of age and sex on hepatic lesions induced by chemical carcinogens: ingestion of 3'-methyl-4-dimethylaminoazobenzene by Buffalo strain rats. PMID- 4333771 TI - Adenine phosphoribosyltransferase activities of mouse ascites tumors and derived tumorigenic and nontumorigenic tissue culyures. PMID- 4333772 TI - Chimerism in lymphoid cell culture line derived from lymph node of marmoset infected with Herpesvirus saimiri. PMID- 4333773 TI - Continuous lymphoblastoid cell line from a rhesus monkey with myelogenous leukemia. PMID- 4333774 TI - Characteristics of avian transmissible lymphoid tumor cells maintained in culture. PMID- 4333775 TI - Tumor suppression by cell walls of mycobacterium bovis attached to oil droplets. PMID- 4333776 TI - Inhibition of nicotinate phosphoribosyl transferase by nonsteroidal anti inflammatory drugs: a possible mechanism of action. PMID- 4333777 TI - Microscopic observation of skeletal muscle vascular responses to vasopressors during severe hemorrhagic hypotension. PMID- 4333779 TI - [Clinical picture of celiac disease at this era of diagnostic facilitation]. PMID- 4333778 TI - [Changes of serum angiotensionogen concentration in acute hepatitis and liver cirrhosis]. PMID- 4333780 TI - Inhibition by penicillamine of DNA and protein synthesis by human bone marrow. PMID- 4333781 TI - Yellow fever vaccine. IV. Reactogenicity and antibody response in volunteers inoculated with a vaccine free from contaminating avian leukosis viruses. PMID- 4333782 TI - Hormone effects upon cyclic nucleotide excretion in man. PMID- 4333783 TI - The antiviral activity of a triazinoindole (SK&F 30097). PMID- 4333784 TI - Impairment of interferon production in mice infected with Mycobacterium lepraemurium. PMID- 4333785 TI - Inhibitory effect of propranolol on hyperglycemia induced by dibutyryl 3',5' cyclic AMP. PMID- 4333786 TI - Reversible suppression of alkaline phosphatase in human thyroid medullary carcinoma cells transformed by SV40. PMID- 4333787 TI - Isolation of an adenovirus 32 strain from human brain in a case of subacute encephalitis. PMID- 4333788 TI - Fat cell adenylate cyclase activation by sheep -lipotropic hormone. PMID- 4333789 TI - Oncogenicity and cell transformation by papovavirus SV40: the role of the viral genome. PMID- 4333790 TI - Electron spin resonance studies of carcinogenesis. PMID- 4333792 TI - The need for additional succinylcholine after d-tubocurarine. PMID- 4333791 TI - Nasopharyngeal carcinoma (NPC). PMID- 4333793 TI - [Neuronal structure of the Pml 1 area of the periamygdalar cortex of the cat brain]. PMID- 4333794 TI - [Histochemical periodate-reactivity of sulfated polysaccharides of the main cells in gastric fundal glands of dogs]. PMID- 4333795 TI - [Neuro-leprosy: value of electromyography]. PMID- 4333796 TI - [Normalizing glucose metabolism in brain tumor slices by hyperoside]. PMID- 4333797 TI - [Observations in the identification test of -phenyl- -N-( -phenylisopropyl) aminoacetonitrile]. PMID- 4333798 TI - Solution electron paramagnetic resonance spectra of hemoproteins at room temperature. PMID- 4333799 TI - Separation of proteins by ammonium sulfate gradient solubilization. PMID- 4333800 TI - Adrenocorticotropin. Solid-phase synthesis of 1-19 -adrenocorticotropic hormone, alanyl- 1-19 -adrenocorticotropic hormone, and prolyl- 1-19 adrenocorticotropic hormone and their adrenocorticotropic activity. PMID- 4333801 TI - Phospholipase A activity of lysosomes of rat myocardial tissue. PMID- 4333803 TI - Relative importance of the enzymic hydrolysis of suxamethonium in plasma and tissues: studies in cats. AB - 1. The effects of intravenous infusions of suxamethonium on the twitch tension of the indirectly stimulated tibialis and gastrocnemius muscles of anaesthetized cats were recorded. From these data the infusion rate giving a 50% reduction in twitch tension after 15 min (IR50), was calculated.2. Marked inhibition of cholinesterase activity in plasma with less inhibition of cholinesterase activity in tissues, obtained by repeatedly withdrawing blood samples, incubating them with DFP and reinjecting them, had only a small effect on the IR50 of suxamethonium.3. Injection of iso-OMPA produced marked inhibition of cholinesterase activity in plasma and tissues, and lowered the IR50 to 10% of that in controls. The IR50 in cats treated with iso-OMPA could be restored to normal only by raising the suxamethonium hydrolysing capacity of plasma 10-50 times above normal by the intravenous injection of purified cholinesterase of human plasma.4. Exchange blood transfusion between normal cats and cats treated with iso-OMPA failed to affect the IR50 of suxamethonium in either of the two.5. It is concluded that in cats, unlike in man, the effectiveness of suxamethonium is not determined by the cholinesterase activity in plasma but by the cholinesterase activity in tissue. The role in this of cholinesterase at the neuromuscular junction and other sites is discussed. PMID- 4333804 TI - Effect of flow-stop on noradrenaline release from normal spleens and spleens treated with cocaine, phentolamine or phenoxybenzamine. AB - 1. Cat spleens were perfused with Krebs-bicarbonate solution, using a constant flow pump at a rate of about 7 ml/min at 33-35 degrees C. Noradrenaline (NA) overflow by nerve stimulation at 10 Hz for 20 s was determined with or without flow-stop before and after treatment with cocaine, phentolamine or phenoxybenzamine. In order to determine the effect of flow-stop on overflow, the arterial and the venous flows were occluded by clamping the inflow and outflow tubes during the period of stimulation plus 30, 60 or 120 seconds.2. Without flow stop, NA output was 0.93+/-0.25 ng/stimulus, which was significantly increased after cocaine (123+/-6.6%), phentolamine (415+/-93%) and phenoxybenzamine (578+/ 107%). Phentolamine and phenoxybenzamine were much more effective than cocaine in enhancing overflow.3. Before treatment with drugs, flow-stops of 30, 60 and 120 s reduced NA outputs to 70+/-6.6, 27.5+/-2 and 7%, respectively, of the control outputs without flow-stop. None of the drugs significantly influenced the percentage reductions in NA outputs during a 30 s flow-stop. However, the percentage outputs after cocaine or phenoxybenzamine treatment during a 60 s flow stop significantly increased to 45+/-2.5% and 57+/-6%, respectively, as compared to the percentage output of 27.5+/-2% from untreated spleens during a corresponding flow-stop period. During flow-stop, there was no appreciable metabolism of the released transmitter.4. Diffusion of the released transmitter from the site of liberation plays only a minor role in the removal of the released NA.5. It is suggested that the NA released by nerve stimulation acts on the presynaptic alpha sites to inhibit its own release by a negative feedback mechanism. Adrenoceptor blocking agents enhance the NA overflow from spleen because they remove this autoinhibition by blocking the presynaptic alpha sites. PMID- 4333802 TI - Mesenteric vasoconstriction after endotoxin administration in cats pretreated with aspirin. AB - 1. Study of the delayed responses to lethal doses of endotoxin in cats is complicated by acute pulmonary vasoconstriction which results in hypotension, cardiac failure and pulmonary oedema. This acute response is abolished if the animal is pretreated with aspirin (10-100 mg/kg). In these cats, pretreated with aspirin, arterial pressure and right atrial pressure remain unchanged in the first 2 h after administration of endotoxin. Later, arterial pressure falls and the animals die but no haemorrhagic lung lesions are visible.2. These results confirm our previous conclusion that the delayed lethal response to endotoxin is an independent action and not a secondary consequence of the acute response. The mechanism of the action of aspirin is discussed and it is suggested that it prevents the release by endotoxin of vasoactive substances, possibly from platelets.3. In cats pretreated with aspirin, administration of endotoxin results in a marked mesenteric vasoconstriction. Although arterial pressure does not decrease significantly, superior mesenteric arterial flow decreases to 20% of control in the first hour after endotoxin and remains at this low level until the animal dies. Mesenteric ischaemia may contribute to the cat's death.4. The mesenteric vasoconstriction is not reduced by prior administration of phenoxybenzamine and is only slightly reduced after phenoxybenzamine, hypophysectomy and nephrectomy. It is concluded that catecholamines, vasopressin and angiotensin play at most a minor role in the mechanism of this vasoconstriction and that other unknown factors are predominant. PMID- 4333805 TI - Specific antagonists for the myotropic action of angiotensin II and angiotensin I on the isolated rat colon. AB - Substitutions of 8 phenylalanine with L-alanine and D-phenylalanine abolish the myotropic action of the angiotensin II (AT(II)) analogues and confer inhibitory properties on the molecule. [8-L-Ala]-AT(II) and [8-D-Phe]-AT(II) antagonize specifically the myotropic action of AT(II) and angiotensin I (AT(I)) on the rat colon, while the action of other myotropic agents (acetylcholine, 5 hydroxytryptamine) is not modified. PMID- 4333806 TI - Specific inhibitors for angiotensin II and angiotensin I. PMID- 4333807 TI - Effect of monoamine oxidase (MAO) inhibition upon the N, P and LN potentials of the rabbit superior cervical ganglia. PMID- 4333808 TI - Action of imipramine on 5-hydroxytryptaminergic transmission and on 5 hydroxytryptamine uptake in the snail (Helix pomatia) brain. PMID- 4333809 TI - Release of acetylcholine and 14 C-glycine from the cat spinal cord in vivo. PMID- 4333810 TI - Uptake of 14 C-L-glutamate by rat retina. PMID- 4333811 TI - Microinjection study of the role of adrenergic transmission in the control of the secretion of antidiuretic hormone. PMID- 4333812 TI - Effect of the monoamine oxidase inhibitor pargyline on the uptake of labelled noradrenaline by the cat's spleen. PMID- 4333813 TI - Investigations of liver biopsies for Australia antigen by immunofluorescent technique. PMID- 4333815 TI - [Localization of sensory zones in the dolphin cerebral cortex]. PMID- 4333814 TI - Immune complex diseases. I. Pathological changes in the kidneys of BALB-c mice neonatally infected with Moloney leukaemogenic and murine sarcoma viruses. PMID- 4333816 TI - Staff education for continuity of care. PMID- 4333817 TI - Cytophysiology of the teleost pituitary. PMID- 4333818 TI - Ecdysone-related changes at the nuclear and cytoplasmic level of malpighian tubule cells in Drosophila. PMID- 4333819 TI - Fine structure of frozen-etched lipid granules in the fat body of an insect. AB - Lipid storage in fat-body cells of adult female black flies was examined using freeze-etching electron microscopy. Frozen-etched lipid granules exhibited a laminated structure. The molecular arrangement of the lipid granule may depend on the physiological condition of the insect and may be involved in the control of lipid metabolism in the fat-body cell. PMID- 4333820 TI - Selective loss of adipose cell responsiveness to glucagon with growth in the rat. AB - In isolated fat cells, the same maximal rate of glycerol production can be induced by epinephrine or ACTH, alone or in combination with each other or with glucagon. With fat cells from rats weighing 150-175 g, the maximal rate of lipolysis attained with glucagon was 75-80% of that produced by epinephrine or ACTH, and with increasing size of the donor rat, the magnitude of the effect of glucagon relative to that of the other hormones declined markedly. In particulate preparations from fat cells of rats weighing 100-125 g, the maximal effect of glucagon on adenyl cyclase activity was about 60% of that of epinephrine, and was significantly less (30%) in preparations from 350-400 g rats. These data are consistent with the hypothesis that with growth of the rat there is a selective decline in the number of glucagon receptors relative to those for epinephrine or ACTH in the fat cell membrane. PMID- 4333821 TI - Thermal and pH stability of 2 -isopentenyl pyrophosphate. AB - The isoprenoid precursors Delta(3)-isopentenyl pyrophosphate and gamma,gamma dimethylallyl pyrophosphate (Delta(2)-isopentenyl pyrophosphate) have been separated by thin-layer chromatography. The products from Delta(2)-isopentenyl pyrophosphate incubated under various conditions of pH and temperature have been separated, and the survival of Delta(2)-isopentenyl pyrophosphate under these conditions has been calculated. The acid-labile Delta(2)-isopentenyl pyrophosphate can be stored indefinitely at pH 11.5 and -100 degrees C. PMID- 4333822 TI - Stability of unsaturated methyl esters of fatty acids on surfaces. AB - The stability of unsaturated methyl esters is greater when they are adsorbed on silica gel than when a glass surface is used. Storage of small samples adsorbed on silica gel may be a convenient addition to conventional methods of protecting labile fats against autoxidation. PMID- 4333823 TI - Adrenocorticotropin. 40. The synthesis of a protected nonapeptide and of a biologically active nonadecapeptide related to adrenocorticotropic hormone. (5 glutamine) adrenocorticotropin-(1-19). PMID- 4333824 TI - Antiviral agents. 5H-as-Triazino(5,6-b) indoles. PMID- 4333825 TI - Effects on neuromuscular function of acute chronic exposure to cholinesterase inhibitors in man and in the rat. PMID- 4333826 TI - Respiratory movements and rapid eye movement sleep in the foetal lamb. AB - 1. In foetal lambs from 40 days gestation (0.27 of term) onwards delivered into a warm saline bath, apparently spontaneous breathing movements were present intermittently. They became deeper and more rapid with increasing age.2. In foetal lambs (from 0.66 of term) in which observations were made for many days after chronic implantation of tracheal, carotid and amniotic catheters, rapid irregular respiratory movements were present up to 40% of the time, and brief gasps also were seen.3. The presence of these movements was unrelated to the foetal carotid blood gas values over a wide range of spontaneous variation.4. These foetal breathing movements were accompanied by comparatively small alterations of pulmonary volume recorded from a tracheal flowmeter, insufficient to clear the tracheal dead space. Occasionally a more prolonged expiration led to the outward flow of fluid.5. A description is given of sleep and wakefulness in foetal lambs from 0.78 of term.6. Rapid irregular breathing was associated with rapid eye movement sleep as seen in a warm saline bath or, in utero, as inferred from records of eye movements and electrocortical activity.7. Respiratory movements were often associated with relatively large variations in foetal heart rate, blood pressure and descending aortic blood flow.8. Rapid irregular foetal breathing was unaffected by section or blockade of the cervical vagi, but was abolished by general anaesthesia.9. It is concluded that respiratory movements are normally but intermittently present in the foetal lamb over the greater part of gestation. PMID- 4333827 TI - Adrenergic re-innervation of smooth muscle of nictitating membrane by preganglionic sympathetic fibres. AB - 1. The preganglionic and post-ganglionic trunks of the cervical sympathetic nerve were joined in an end-to-end anastomosis after excision of the superior cervical ganglion in the cat.2. Seventy-five days after the anastomosis the diameter of the pupil was nearly normal and there was almost complete recovery of the prolapsed palpebra and of the nictitating membrane. The contraction of the nictitating membrane, induced by electrical stimulation, caudally to the point of anastomosis, showed that the smooth muscle of the nictitating membrane had been re-innervated.3. Neither hexamethonium nor nicotine had any marked effect on the contraction of the nictitating membrane. Severing the regenerated nerve trunk produced a degeneration contraction. These results are strong evidence that the denervated membranes were re-innervated by true cholinergic preganglionic fibres.4. Our pharmacological studies indicated that in the re-innervated preparations neuromuscular transmission was adrenergic in the sense that it was blocked by phentolamine and not by atropine. These results were confirmed by the histochemical-fluorescence studies which showed that the endings of the regenerated axons contained high concentrations of catecholamines.5. Electron microscopy showed that the regenerated terminals contained none of the small dense-core vesicles, considered to be typical of adrenergic nerve endings, but contained clear synaptic vesicles and an unusually great number of large granular vesicles.6. Our results suggest that the denervated nictitating membranes were re innervated by cholinergic presynaptic sympathetic fibres that had been modified so that they could release catecholamines in addition to, or instead of, acetylcholine. PMID- 4333828 TI - The effect of angiotensin, noradrenaline and vasopressin on blood flow distribution in the rat kidney. AB - 1. The effect of val(5)-angiotensin II amide, noradrenaline and vasopressin, on kidney volume and intrarenal distribution of carbon particles and thioflavine S was examined in the rat.2. Angiotensin produced a dose-dependent shrinkage of the kidney coinciding with the rise in systemic blood pressure. Noradrenaline and vasopressin, however, produced reduction in kidney volume only in much higher doses than were necessary to produce a pressor effect.3. An intravenous infusion of angiotensin sufficient to produce a diuretic response resulted in a striking increase in glomerular content of injected carbon particles, and a marked reduction in filling of the capillary plexuses of the subcortex and outer medulla. The reduction in outer medullary filling was also observed using the thioflavine S technique.4. Noradrenaline infused in amounts sufficient to produce diuresis, aortic constriction above the kidney and vasopressin injection produced no measurable change in carbon particle distribution.5. The reduction in capillary blood flow produced by angiotensin may result in impaired tubular reabsorptive capacity by reducing peritubular removal of reabsorbate, or by reducing oxygen availability. Thus the vasoconstrictor effects of angiotensin may explain its diuretic action. PMID- 4333829 TI - Pharmacological properties, cholinesterase activity and anatomy of nerve-muscle junctions in vagus-innervated frog sartorius. AB - 1. The pharmacological properties of the nerve-muscle junctions of vagus innervated frog sartorius muscles were investigated. Vagus-evoked junctional potentials were ten times more sensitive to hexamethonium than were control end plate potentials from muscles re-innervated with sartorius nerve. Hexamethonium did not affect passive electrical muscle membrane properties or quantal content. The sensitivity of vagus junctions to D-tubocurarine (dTC) did not differ from the controls.2. The amplitude and time course of vagus-evoked junctional potentials were not affected by eserine or neostigmine. Furthermore, histologically detectable acetylcholinesterase activity was not demonstrable at vagus-muscle junctions.3. The ultrastructure of vagus-innervated muscle fibres was normal in appearance indicating that the vagus was capable of structurally maintaining the muscle fibres.4. Junctional contacts were made by varicosities of unmyelinated vagal fibres. Although such varicose vagal fibres ran along the muscle fibres for long distances, they seemed to make synaptic contacts primarily at old end-plate regions, as deduced from persisting junctional folds.5. It is concluded that at least several ;trophic' factors are probably involved in the different effects of the vagus nerve on the sartorius muscle. PMID- 4333830 TI - Interactions of drugs and amines in the brain. PMID- 4333831 TI - The localization of the Na + -K + -ATPase in the cells of rat kidney cortex. A study on isolated plasma membranes. PMID- 4333833 TI - [Frey's syndrome]. PMID- 4333832 TI - Quantal release of acetylcholine from the nerve endings of the guinea-pig superior cervical ganglion. PMID- 4333834 TI - Current model of the mechanism of action of hormones (illustrated by the ACTH corticosteroid system and cyclic AMP mediation). PMID- 4333835 TI - Serotonin and the alimentary tract. PMID- 4333836 TI - Malignancy and immunosuppression. Renal homotransplantation in patients with primary renal neoplasms. PMID- 4333837 TI - The influence of immunosuppression and allografting on virus-induced lymphatic leukemia in mice. PMID- 4333838 TI - Cell population changes in regenerating thymus grafts. PMID- 4333839 TI - Some geometrical aspects of the neocortical neuropil. PMID- 4333840 TI - Function-dependent alterations in the distribution of synaptic vesicles. PMID- 4333841 TI - Fine structure of the peripheral sensory cells in the earthworm Dendrobaena octaedra. I. The solitary sensory cell. PMID- 4333842 TI - Lysosomes in Tetrahymena pyriformis. II. Intracellular distribution of several acid hydrolases. PMID- 4333843 TI - [Granular cell myoblastoma located in the gluteal region. Report of a case]. PMID- 4333844 TI - [Iododesoxycytidine, a new virostatic against herpetic keratitis. Experimental study]. PMID- 4333845 TI - [Quantitative evaluation of several age changes in the skeleton]. PMID- 4333846 TI - [Histo-enzymologic characteristics of the skin of patients with lepromatous leprosy]. PMID- 4333847 TI - The coexistence of two metabolic pathways in the meta cleavage of catechol by Pseudomonas putida N.C.I.B. 10105. PMID- 4333848 TI - The physiologic significance of the two divergent metabolic steps in the meta cleavage of catechols by Pseudomonas putida N.C.I.B. 10105. PMID- 4333849 TI - The development of gluconeogenesis in rat liver. Controlling factors in the newborn. AB - 1. Measurements in livers of rats delivered by Caesarian section show a rapid change in the relative proportion of adenine nucleotides. By 20min the ATP/ADP ratio had increased from 1.76 to 8.7 and the value of the relationship [ATP][AMP]/[ADP](2) increased from 1.0 to 4.4. These changes are dependent on the availability of oxygen to the animal. 2. The free [NAD(+)]/[NADH] ratio in the liver cytosol increases from 180 after delivery to reach a maximum of 1010 at 2h, before falling to 540 in the 24h-old animal. 3. The mitochondrial NAD redox potential also shows a sharp increase towards a more oxidized state in livers of delivered rats. 4. These results probably indicate that the foetal liver is hypoxic, with oxygenation occurring in the first hour after delivery. 5. Measurements in livers of naturally born rats 2min after birth also suggest that this tissue is hypoxic with an ATP/ADP ratio of 1.83 and a free [NAD(+)]/[NADH] ratio of 117. 6. Concentrations of intermediates in the gluconeogenic pathway have been determined in livers of foetal, 1h-old and 1-day-old rats. These experiments imply a facilitation of lactate dehydrogenase and glucose 6 phosphatase activities by 1h after birth, and a stimulation of phosphoenolpyruvate carboxykinase and glucose 6-phosphatase steps by 1 day after birth. 7. The appearance of gluconeogenesis in livers of newborn rats seems therefore to involve an oxygenation stage followed by an increase in phosphoenolpyruvate carboxykinase activity. PMID- 4333850 TI - Turnover of protein-bound phosphorylserine in membrane preparations from ox brain catalysed by intrinsic kinase and phosphatase activity. AB - 1. The turnover of protein-bound phosphorylserine in preparations of membrane fragments from ox brain cortex was studied. 2. Turnover was considered to arise from the action of intrinsic protein kinases and phosphatases on a membrane protein or proteins. 3. Properties of the kinase system were studied by measuring the rate of incorporation of (32)P from gamma-labelled ATP into protein-bound phosphorylserine isolated from partial acid hydrolysates of membrane proteins. 4. Properties of the phosphatase system were studied by observing the rate of loss of (32)P from membrane preparations pre-labelled with [(32)P]ATP. 5. Net phosphorylation and dephosphorylation of membrane protein was observed during incubation of membrane preparations with and without ATP. 6. The rate of turnover was about 4nmol of P/h per mg of protein at 20 degrees C; dephosphorylation was considered to be the rate-limiting step. PMID- 4333851 TI - The enzymes forming isopentenyl pyrophosphate from 5-phosphomevalonate (mevalonate 5-phosphate) in the latex of Hevea brasiliensis. AB - 1. Phosphomevalonate kinase and 5-pyrophosphomevalonate decarboxylase have been purified from the freeze-dried latex serum of the commercial rubber tree Hevea brasiliensis. 2. The phosphomevalonate kinase was acid- and heat-labile and required the presence of a thiol to maintain activity. 3. The 5 pyrophosphomevalonate decarboxylase was relatively acid-stable and more heat stable than the phosphokinase. 4. Maximum activity of the phosphokinase was achieved at pH 7.2 with 0.2mm-5-phosphomevalonate (K(m) 0.042mm), 2.0mm-ATP (K(m) 0.19mm) and 8mm-Mg(2+) at 40 degrees C. The apparent activation energy was 14.8kcal/mol. 5. Maximum activity of 5-pyrophosphomevalonate decarboxylase was achieved at pH5.5-6.5 with 0.1mm-5-pyrophosphomevalonate (K(m) 0.004mm), 1.5mm ATP (K(m) 0.12mm) and 2mm-Mg(2+). The apparent activation energy was 13.7kcal/mol. The enzyme was somewhat sensitive to inhibition by its products, isopentenyl pyrophosphate and ADP. PMID- 4333853 TI - The pH dependence of calcium adsorption onto anionic phospholipid monolayers. PMID- 4333852 TI - Significance of the caffeine-like effect of various purines, pyrimidines and derivatives on adipose-tissue phosphodiesterase. PMID- 4333854 TI - [Effect of changes in sensitivity of gonadal interoceptors on the excitation of vasomotor points]. PMID- 4333855 TI - [Possible role of hydrodynamic factors in synaptic transmission]. PMID- 4333856 TI - [Tremor development in dogs caused by stimulation of the dorsal hippocampus]. PMID- 4333857 TI - Genetic diseases and developmental defects analyzed in allophenic mice. PMID- 4333859 TI - The murine sarcoma virus (MSV). PMID- 4333858 TI - The role of membranes in the replication of animal viruses. PMID- 4333860 TI - Diagnostic abdominal radioisotopic lymphography and radiation therapy. PMID- 4333861 TI - Effects of descending impulses on transmission through the spinocervical tract. AB - 1. Micro-electrode recordings were made from ascending axons of the spinocervical tract in unanaesthetized decerebrate cats before, during and after reversible cold block of impulse conduction in the spinal cord rostral to the recording site.2. Most units (forty-one of forty-four) fell into one of four categories as defined by their evoked responses to mechanical stimulation of identified cutaneous receptors. These categories were; Type I excited by movement of tylotrichs (hairs) in the decerebrate preparation but by movement of all types of hairs after block of descending impulses; Type II excited by movement of guard hairs and usually weakly by pressure in the decerebrate state but by movement of all types of hairs and by pressure in the spinal state; Type III excited by movement of all types of hairs and often by pressure in the decerebrate animal but by movement of all types of hairs and always by pressure in the spinal animal; Type IV weakly excited by heavy pressure or with no receptive field in the decerebrate state but excited by pressure in the spinal state.3. The descending influences depressed the spontaneous activity and the evoked responses to harmful stimuli.4. The descending influences depressed inhibitory inputs from segmental levels.5. The functional significance of the descending control is discussed. PMID- 4333862 TI - Changes in the physiology and fine structure of the taenia of the guinea-pig caecum following transplantation into the anterior eye chamber. AB - 1. The taenia of the guinea-pig caecum has been used as a model to study the re establishment of autonomic innervation following transplantation into the anterior eye chamber. The ultrastructure, the histochemical localization of noradrenaline and acetylcholinesterase and the pharmacology of transmission to the taenia have been examined 1 day to 16 weeks following transplantation. Both ganglion-free strips of the taenia and caecal wall segments including the underlying Auerbach's plexus were used.2. Caecal wall preparations: nerve fibres from intramural ganglion cells retracted during the first 2 days following transplantation, but reappeared in the muscle soon afterwards. Adrenergic nerves from the iris formed terminals about ganglion cells at about 2-4 weeks. Both cholinergic excitatory and non-adrenergic (;purinergic') inhibitory transmission to the muscle was re-established by 2-4 days following transplantation.3. Taenia strip preparations: both adrenergic and cholinergic nerve fibres were demonstrated histochemically in muscle bundles by 2-4 weeks. Non-adrenergic inhibitory and cholinergic transmission was not re-established until 2-4 weeks following transplantation. There was an abnormally dense re-innervation of the muscle by adrenergic nerve fibres by about 8 weeks which is compared with the innervation of aganglionic bowel in Hirschsprung's disease.4. The origin of non adrenergic inhibitory responses in the transplanted taenia is discussed and the results considered in relation to the re-innervation of transplants of the vas deferens and of intestine during early development. PMID- 4333863 TI - Frequency-response analysis of central vestibular unit activity resulting from rotational stimulation of the semicircular canals. AB - 1. The neural response of semicircular canal-dependent units in the vestibular nuclei of cats has been examined over a frequency range of sinusoidal rotation extending from 0.004 to 0.9 Hz.2. Frequency-response analysis indicates that, over the range examined, the information contained in the neural signal received by the brain stem was similar to that expected from the mechanical end-organ.3. Over the experimental frequency range, the relation between neural response and mechanical stimulus was found to be dominated by a single time constant of about 4 sec, such that two response regions can be defined above and below a stimulus frequency of (1/4) rad/sec ( approximately approximately Hz).4. Above this frequency the information content of the neural signal tends towards that of angular velocity and below that frequency it tends towards that of angular acceleration.5. It is inferred (a) that the so-called ;long' time constant of the cat's horizontal canal is about 4 sec and (b) that during most normal head movements containing frequencies below about 1 Hz the informational mode of neural signals generated in the canal and received in the brain stem probably tends towards that of head angular velocity.6. This seems appropriate for the generation of vestibulo-ocular reflex compensation for head movement and for reflex damping (negative velocity feed-back) of unintended head and body movements.7. The average neural gain of central unit responses is estimated at 1264 action potentials/sec, per degree of cupular deflexion. This high value reflects the very small angles of cupular deflexion assessed on the basis of physical characteristics of the canal.8. The results permit a rough estimate of the elastic restoring coefficient of the cupula in the horizontal canal as 2.05 x 10(-3) dyne. cm. PMID- 4333864 TI - Ultrastructure and biochemical properties of subcellular fractions from rat renal medulla. PMID- 4333865 TI - Ultrastructural localization of aryl sulfatase activity in the epiphyseal plate. PMID- 4333866 TI - [Synaptic transmission in Renshaw cells (review)]. PMID- 4333867 TI - [Inhibition in somatosensory cortex neurons and possibility of intracortical propagation of excitation]. PMID- 4333868 TI - [Convergence of signals of different sensory modalities on neurons in the rabbit sensory motor cortex]. PMID- 4333869 TI - [Responses of orbitofrontal cortex neurons to stimulation of the limbic structures]. PMID- 4333871 TI - [Background activity of amygdaloid complex neurons nd its changes caused by stimulation of the hippocampus]. PMID- 4333870 TI - [Neuron activity of the cat thalamic pulvinar]. PMID- 4333872 TI - [Corticofugal effects on trigeminal motor neurons]. PMID- 4333873 TI - [Relation between amplitudes of initial potentials of primary responses on the surface and in the deep layers of the cortex]. PMID- 4333874 TI - [Electric transmission between non-symmetrical neurons in the leech ganglion]. PMID- 4333875 TI - [Re-evaluation of kidney function tests--wtih special reference to routine clinical diagnostic tests]. PMID- 4333876 TI - Optimum age for vaccinating chickens against Marek's disease. PMID- 4333877 TI - [Behavior of focal epileptic EEG potentials in sleep. Epicritical analysis of recovered cases following surgical intervention]. PMID- 4333878 TI - [Epilepsy and sleep. Quantitative changes of epileptic potentials during the course of the night]. PMID- 4333879 TI - [Modifications of the rapid activity of the EEG of children in relation to various phases of sleep]. PMID- 4333880 TI - [Effects of the miction reflex on various phases of cerebral electric activity in sleep in enuretics]. PMID- 4333881 TI - The biological and pharmacological properties of some fibrinogen degradation products. PMID- 4333882 TI - Acetylcholine: possible neuromuscular transmitter in Crustacea. AB - The tonic flexor muscles of the crayfish abdomen respond with a large depolarizing potential to acetylcholine iontophoresed onto a neuromuscular Junction, but not to glutamate. Excitatory junctional potentials are abolished by d-tubocurarine and enhanced by a cholinesterase inhibitor. The membrane is depolarized and the junctional potentials are desensitized by excess acetylcholine. Thus acetylcholine is thought to be the neuromuscular transmitter. PMID- 4333883 TI - [Method of identifying strains of foot-and-mouth disease virus]. PMID- 4333884 TI - [Distribution of Clostridium perfringens in pasture soil]. PMID- 4333885 TI - [Interaction of the foot-and-mouth disease virus with cells]. PMID- 4333886 TI - [A quantitative method for the determination of urinary aldosterone by direct measurement of UV-remission on the thin-layer plate]. PMID- 4333887 TI - The face and jaws after surgical experimentation with the septovomeral region in growing and adult rabbits. PMID- 4333888 TI - An effect of ACTH on the metabolism of 1,2 3 H corticosterone by a cell free rat adrenal preparation. PMID- 4333889 TI - Estriol excretion profiles in narcotic-addicted pregnant women. PMID- 4333890 TI - Familial florid papillomatosis of the nipple. PMID- 4333892 TI - Antiviral activity in tissue culture systems of bis-benzimidazoles, potent inhibitors of rhinoviruses. AB - (S,S)-1,2-bis(5-methoxy-2-benzimidazolyl)-1,2-ethanediol showed antiviral activity in monolayer tissue culture systems against 55 strains of rhinovirus, three types of poliovirus, and strains of type A and B coxsackieviruses. Neither the compound nor any of the analogues tested showed virucidal activity. Its antiviral activity was not associated with interference with viral attachment to or penetration into the cell. At a concentration of 0.1 mg/ml, this group of compounds was generally nontoxic to WI-38, primary bovine kidney, and African green monkey kidney cells and had antiviral activity with 100% inhibition of virus-induced cytopathic effects (CPE). At antiviral levels, these compounds prevented CPE of up to 10(6) median tissue culture infective dose units of virus and completely inhibited formation of new infective virions. The compounds showed antiviral activity both prophylactically and therapeutically against rhinoviruses. Infected cultures could be cleared of CPE up to 90 hr after infection. PMID- 4333891 TI - Viral syndromes and renal homograft rejection. PMID- 4333893 TI - Antiviral activity of a bis-benzimidazole against experimental rhinovirus infections in chimpanzees. AB - The marked antiviral activity of (S,S-1,2-bis(5-methoxy-2-benzimidazolyl)-1,2 ethanediol (Abbott 36683) against rhinoviruses in tissue culture warranted investigation of its antiviral activity in vivo. Antiviral levels in mouse sera were attained with an oral dose as small as 10 mg/kg and detectable antiviral levels of drug were also found in lung, liver, kidney, intestinal contents, and urine of mice given a single 300 mg/kg oral dose. Antiviral serum levels were also obtained when monkeys were given a single oral dose of Abbott 36683. Six chimpanzees were infected with 100 median tissue culture infective dose units (TCID(50)) of rhinovirus 30. Three of the animals were treated with Abbott 36683, 100 mg/kg daily for 4 consecutive days. Virus shedding occurred in the infected controls but could not be demonstrated in the treated animals from postinfection days 1 to 8. Two of the treated animals did, however, shed virus on day 9. The compound was retested in chimpanzees at dosage levels of 15 and 50 mg/kg daily for 4 days. Each animal was challenged with 100 TCID(50) of rhinovirus 49. Partial protection was obtained. In a third trial, a single 100 mg/kg dose of the compound was administered to chimpanzees infected with rhinovirus 44. Virus was isolated from all throat smears taken from treated animals, indicating that at the lowest drug level no protection occurred. PMID- 4333894 TI - Preliminary observations on the uptake poliovirus by West Coast shore crabs. AB - West Coast shore crabs (Pachygrapsus sp. and Hemigrapsus sp.), when in seawater contaminated with poliovirus or allowed to feed on virus-contaminated mussels (Mytilus californianus), were found to accumulate high titers of virus. PMID- 4333895 TI - Long-term preservation of bordetella pertussis. AB - Viability of Bordetella pertussis was preserved when glycerol broth suspensions were quick frozen and stored at -70 C for as long as 45 months. PMID- 4333896 TI - Use of dogs as an assay for Clostridium perfringens enterotoxin. AB - Three techniques for using the dog as an assay organism for Clostridium perfringens enterotoxin are described. These are believed to be more convenient than ligated ileal-loop procedures. PMID- 4333898 TI - Passive hemagglutination-inhibition test for typing foot-and-mouth disease virus. AB - In addition to currently used serological tests for the occurrence of foot-and mouth disease virus (FMDV), a specific "passive" hemagglutination-inhibition (HAI) test has been developed as a supplement. Serial twofold dilutions of antiserum (0.05 ml) were mixed with 0.05 ml of a constant concentration of FMDV. After incubating for 30 min at 37 C, agglutinating antibodies were determined by adding 0.1 ml of 2.5% virus-sensitized erythrocytes. The minimum concentration of antiserum required to agglutinate the erythrocytes defined the inhibition in the HAI test. Similar tests using different concentrations of virus to inhibit antibodies were carried out in parallel fashion. The relationship between the logarithm of the HAI titer and the concentration of inhibiting virus was nearly first order (P > 0.25). The slope was used as a measure of the relative specificities of the antigen-antibody interaction and was independent of concentration. The HAI test was type-, subtype-, strain-, and variant-specific with the viral antigens used. In particular, typing was performed directly on bovine antisera. PMID- 4333899 TI - Electron microscopic study of cadmium nephrotoxicity in the rat. PMID- 4333897 TI - Procedure for isolation and enumeration of Vibrio parahaemolyticus. AB - An evaluation of criteria used in the identification of Vibrio parahaemolyticus showed that cultural responses varied with respect to growth in broth with 10% NaCl, type of hemolysis, reactions in triple sugar-iron-agar, and serological reactions. With few or no exceptions, cultures were positive for cytochrome oxidase, utilized glucose fermentatively, were sensitive to pteridine (0/129) and novobiocin, and failed to grow in Trypticase soy broth (TSB) without NaCl. A procedure employing a direct plating technique, with or without prior enrichment, was designed for the isolation and enumeration of V. parahaemolyticus. The plating medium consisted of 2.0% peptone, 0.2% yeast extract, 1.0% corn starch, 7% NaCl, and 1.5% agar, with the pH adjusted to 8.0. The enrichment broth was TSB with 7% NaCl. Dilutions of food homogenates were either spread directly on the plates or inoculated into enrichment broth. TSB enrichments were incubated at 42 C for 18 hr. A loopful of the TSB tubes then was streaked onto the direct plating medium. Incubation of plates was at 42 C for 24 to 48 hr. Smooth, white to creamy, circular, amylase-positive colonies were then picked as suspect V. parahaemolyticus. Confirmation of gram-negative, fermentative, oxidase-positive, pleomorphic rods sensitive to pteridine 0/129 was made by a fluorescent-antibody technique. With this procedure, a satisfactory quantitative recovery of known V. parahaemolyticus from inoculated seafoods was made possible. V. parahaemolyticus was nto isolated from other salted foods. PMID- 4333900 TI - Serological identification of an equine Rhinovirus strain. PMID- 4333901 TI - Ultrastructural comparison of rheumatoid and nonrheumatoid synovial fibroblasts grown in tissue culture. PMID- 4333902 TI - Septic arthritis, gout, pseudogout and osteoarthritis in the knee of a patient with multiple myeloma. PMID- 4333903 TI - [Coordinated changes in activity of glycolytic chain enzymes in loach oogenesis]. PMID- 4333904 TI - [Spin-probe study of structural transitions in biological membranes: temperature changes in bacterial membranes]. PMID- 4333905 TI - [Detection and some properties of Neurospora crassa polyphosphatases hydrolyzing inorganic polyphosphates and orthophosphates]. PMID- 4333907 TI - [Positive control of transcription in eukaryotes]. PMID- 4333906 TI - [Kinetic properties of Clostridium welchii SR-12 glutaminase and effect of some ions on its activity]. PMID- 4333908 TI - [Precipitating antigens in a polyoma tumor-hamster system]. PMID- 4333909 TI - [Lipolysis of isolated adipose cells in rabbits: respective roles of catecholamines, ACTH and hydrocortisone; influence of adrenalectomy]. PMID- 4333910 TI - A comparison of the protective effect against Mengo virus infection in mice of interferons induced by polyI:C and Mengo virus. PMID- 4333911 TI - Clinical neuropathological conference. PMID- 4333912 TI - [Effect of renin and angiotensin on blood coagulation]. PMID- 4333913 TI - [Depolarization of axon terminals of return corticothalamic neurons]. PMID- 4333914 TI - The electron microscope study of secretory transformation of the endometrium and of the endometrium at the outset of pregnancy. PMID- 4333915 TI - [Genetic aspects in dermatology]. PMID- 4333916 TI - Opacification of the mediastinal nodes by the intrapleural injection of two types of emulsions. Study of their effect upon the pleura. PMID- 4333917 TI - Hormonal changes in puberty. 3. Correlation of plasma testosterone, LH, FSH, testicular size, and bone age with male pubertal development. PMID- 4333918 TI - Significance of the iodide-perchlorate discharge test in patients with 131 I treated and untreated hyperthyroidism. PMID- 4333919 TI - Virilizing adrenal hyperplasia presenting in a prepubertal female. PMID- 4333920 TI - [Carcinoid and carcinoid syndrome. Clinical and patho-physiological aspects]. PMID- 4333921 TI - Effect of chloramphenicol infusion on the rate of synthesis of cytochrome oxidase in mammalian embryonic tissue. PMID- 4333922 TI - Effect of ACTH on single unit activity in the diencephalon of intact and hypophysectomized rats. PMID- 4333923 TI - Methemoglobin formation and red cell metabolism in guinea pigs during chronic hypercapnia. PMID- 4333925 TI - [Histogenesis and biological interpretation of important tumoral types in the region of the eye]. PMID- 4333924 TI - [Effects of intra-articular and intraspinal corticotherapy on the hypophyso adrenal axis]. PMID- 4333926 TI - [The panorama, the technic from the viewpoint of the radiologist. New data, demonstration possibilities, indications and picture interpretation]. PMID- 4333927 TI - Fine structure of a potential photoreceptor organ in the larva of Bugula neritina (Bryozoa). PMID- 4333928 TI - Ultrastructure of the cortical cell of the interrenal gland of the American bullfrog (Rana catesbeiana). PMID- 4333929 TI - [Impulse transmission in Lineus sanguineus Rathke (Nemertini). II. The cholinergic nervous system]. PMID- 4333930 TI - [Prevention and therapy of septic diseases in premature and full-term infants]. PMID- 4333931 TI - Observations on the antigen-antibody complex in bovine papillomatosis. PMID- 4333932 TI - Haemophilus somnifer (n. sp.) infection in sheep. PMID- 4333933 TI - The localization of 1,25-dihydroxycholecalciferol in bone cell nuclei of rachitic chicks. AB - 1. A simple technique has been developed to obtain subcellular fractions of chick bone. The method yielded 60-70% of total DNA in the nuclear debris fraction and 80-90% of total (14)C recovered in bone after a dose of radioactive vitamin D. 2. After a dose of [4-(14)C,1,2-(3)H(2)]cholecalciferol (0.5mug) was given to vitamin D-deficient chicks, the time-course of total (14)C radioactivity in the epiphysis, metaphysis and diaphysis of proximal tibiae was measured. The maximum concentrations were reached at 6h, corresponding to a similar peak of radioactivity in blood, decreasing until 24h and indicating the dependence on the circulating (14)C and on the blood supply of the three bone components. 3. The (14)C radioactivity of cholecalciferol and 25-hydroxycholecalciferol (expressed per mg of DNA) followed the pattern of incorporation of total (14)C radioactivity in all three bone components. The more polar metabolite fraction reached a peak of radioactivity at 6-9h and maintained its concentration over the 24h period studied in all anatomical bone components. 4. After a dose of [4-(14)C,1 (3)H]cholecalciferol (0.5mug) was given to vitamin D-deficient chicks, the subcellular distribution was studied. At 24h after dosing, the nuclear fraction contained 27% and the supernatant fraction had 67% of total (14)C recovered in the bone filtrate. When the (14)C in the residual bone fragments was included, the nuclear fraction contained up to 35% of the total radioactivity in the bone. 5. The subcellular distribution pattern of individual vitamin D metabolites indicated that the purified nuclear fraction concentrated the polar metabolite, which lost (3)H at C-1, so that 77% of the radioactivity could be accounted for by 1,25-dihydroxycholecalciferol. The supernatant fraction contained smaller amounts of 1,25-dihydroxycholecalciferol (9%), with 66% of 25 hydroxycholecalciferol forming the major metabolite, corresponding to its concentration found in blood at 24h. 6. The preferential accumulation of 1,25 dihydroxycholecalciferol in the nuclear fraction and the overall pattern of other metabolites, found previously in intestinal tissue, suggests a similar mechanism of action in bone to that postulated for the intestinal cell in calcium translocation. PMID- 4333934 TI - The arrangement of proteins on the deoxyribonucleic acid in chromatin. AB - The arrangement of the protein component on the DNA of the chromatin complex was studied by comparing the rate of release of oligonucleotides and of protein after addition of deoxyribonuclease I and deoxyribonuclease II to rat thymus chromatin. Also the action of deoxyribonuclease I on normal chromatin and on chromatin depleted of non-histone protein was compared, to elucidate the role of the latter protein in chromatin structure. As a preliminary to the above, the rate of action of deoxyribonuclease I on DNA and on chromatin at the same DNA concentration, and the dependence of the action of this enzyme on the Mg(2+) concentration, were studied. It was found that: (1) little if any DNA in chromatin is present in extensive, truly ;free' zones, i.e. completely uncovered by protein; (2) at relatively low concentrations of added Mg(2+), deoxyribonuclease I degrades chromatin more rapidly than DNA; (3) the non-histone protein is not attached directly to the DNA in chromatin. PMID- 4333935 TI - Fractionation of nuclear and cytoplasmic ribonucleic acids from rat tissues on the methylated albumin--kieselguhr column. AB - 1. The conformation of RNA was found to affect its behaviour on methylated albumin-kieselguhr chromatography. The less regular the secondary structure of RNA, the more tightly it binds to the methylated albumin-kieselguhr column. 2. The presence of various denaturing agents (such as urea or perchlorate) in the medium while RNA was adsorbed on the column increased the resolving power of the technique as exemplified by the separation of rat liver rRNA into two distinct peaks. A special procedure for selective adsorption of the cytoplasmic DNA-like RNA on the preparative scale has been developed. Polyribosomal mRNA (rapidly labelled RNA formed in the presence of small doses of actinomycin D) can also be adsorbed selectively by the column. 3. A type of tissue specificity was detected in nuclear RNA from rat liver, kidney, thymus and spleen by using a modified salt and temperature gradient for the chromatographic fractionation (Lichtenstein, Piker & Shapot, 1967; Shapot, Lichtenstein & Piker, 1967). It was also found that cytoplasmic RNA from the different rat tissues contained no tenaciously bound fraction at all, whereas it constituted about 50% of the nuclear RNA. The problem of the possible biological function of the tenaciously bound fraction is discussed. PMID- 4333936 TI - The location of the thiol groups of myosin that are protected by pyrophosphate against reaction with 2,4-dinitrophenyl -hydroxyethyl disulphide. AB - Myosin modified in the presence or in the absence of pyrophosphate by 2,4 dinitrophenyl beta-hydroxyethyl disulphide was treated with iodo[1 (14)C]acetamide. The residual Ca(2+)-stimulated adenosine triphosphatase (ATPase) activity of the modified myosin was different depending on the presence or absence of PP(i) during modification and the number of 2,4-dinitrophenyl beta hydroxyethyl disulphide-modified thiol groups. The radioactivity incorporated into the light components of myosin correlated with the Ca(2+)-stimulated ATPase activity of the modified myosin and decreased with decreasing residual Ca(2+) stimulated ATPase activity of the modified myosin. When native myosin was treated with low concentrations of iodo[1-(14)C]acetamide the residual Ca(2+)-stimulated ATPase activity of carboxyamidomethylated myosin was high and the radioactivity incorporated into the light components of myosin was negligible. The thiol groups of the light components of myosin are essential to preserve the ATPase activity of the protein and are close to the pyrophosphate-binding sites. PMID- 4333937 TI - Studies on N-acetylneuraminic acid aldolase. AB - N-Acetylneuraminic acid aldolase from Clostridium perfringens was irreversibly inactivated by 1mm-bromopyruvate with a half-life of 4.2min at pH7.2 and 37 degrees C. The rate of inactivation was diminished in the presence of pyruvate but not with N-acetyl-d-mannosamine, indicating that the inhibitor acted at, or close to, the pyruvate-binding site. The apparent K(i) for bromopyruvate, calculated from the variation of half-life with inhibitor concentration, was 0.46mm, compared with a competitive K(i) 3.0mm for pyruvate. Incubation of the enzyme with radioactive bromopyruvate gave a radioactive, enzymically inactive, protein in which the bromopyruvate had alkylated cysteine residues. Incubation of the enzyme with radioactive pyruvate, followed by reduction with sodium borohydride, led to inactivation of the enzyme and binding of the pyruvate to the protein by reduction of a Schiff's base initially formed with the in-amino group of a lysine residue; only one-twentieth as many pyruvyl residues were bound by this method, showing that bromopyruvate is not specific for the active site. After protection of the enzyme active site with pyruvate, treatment with unlabelled bromopyruvate and dialysis, the enzyme retained 72% activity. When this treated enzyme was separately incubated with radioactive bromopyruvate, or radioactive pyruvate followed by sodium borohydride, the ratio of radioactive pyruvyl residues bound by the two methods was 2.3:1. After reduction and hydrolysis of the bromopyruvate-treated enzyme, the only detectable radioactive amino acid derivative was chromatographically and electrophoretically identical with S-(3-lactic acid)-cysteine. The enzyme was fully active in the presence of EDTA and was not stimulated by bivalent metal ions. It was strongly inhibited by silver and mercuric ions. The apparent molecular weight, determined by Sephadex chromatography, was 250000. A mechanism of action is proposed for the enzyme. Bromopyruvate reacts rapidly at pH6.0 with thiol-containing amino acids. Cysteine appears to react anomalously. PMID- 4333938 TI - Effects of catecholamines on the formation of adenosine 3':5'-cyclic monophosphate in human blood platelets. PMID- 4333939 TI - Reversion in virus-transformed cells. PMID- 4333940 TI - Mechanisms in cellular metabolic regulation. PMID- 4333941 TI - Phosphoenolpyruvate carboxytransphosphorylase. Study of the catalytic and physical structures. PMID- 4333942 TI - In vitro metabolism of 15 -hydroxyprogesterone by rabbit liver. PMID- 4333943 TI - Conformation of purine nucleoside pyrophophates as studied by circular dichroism. PMID- 4333944 TI - Infrared studies of azide bound to myoglobin and hemoglobin. Temperature dependence of ionicity. PMID- 4333945 TI - Mossbauer parameters of putidaredoxin and its selenium analog. PMID- 4333946 TI - A quantum model for controlled enzymic reactions. PMID- 4333947 TI - Studies on nicotinamide deamidation in rat stomach. PMID- 4333948 TI - [Relation of the biological effect of lipo-peroxidation and free radicals to aging and neoplastic processes]. PMID- 4333949 TI - [The significance of cytomegalovirus as a cause of liver disease in children]. PMID- 4333950 TI - [Effect of ACTH on the sympatico-adrenal system exposed to radiation sources]. PMID- 4333951 TI - [The steroid-sparing effect of disodium cromoglycate in chronic asthma]. PMID- 4333952 TI - Ovarian histochemistry of the fishes Cyprinus carpio, Mugil capito and Tilapia aurea (teleostei). PMID- 4333953 TI - Adenosine triphosphatases and related enzymes of the juxtaglomerular and arteriole smooth muscle cells in rat kidney. PMID- 4333954 TI - Roentgen assessment of bone density in North Indian population. PMID- 4333955 TI - Use of the flame photometric detector for determining residues of omite (2-(p tert-butylphenoxy)cyclohexyl propargyl sulfite) in various crops. PMID- 4333956 TI - Clinicopathological conference of the Medical University of South Carolina. "61 year old man with wasting and bilateral pulmonary infiltrates". PMID- 4333957 TI - [Ectopic ACTH producing tumor]. PMID- 4333959 TI - [Erythropoietin producing tumor]. PMID- 4333958 TI - [Chorionic tumors and TSH]. PMID- 4333960 TI - [Active substances produced by carcinoid tumor]. PMID- 4333961 TI - [Therapeutic experience in primary hepatic cancer]. PMID- 4333962 TI - [Disintegrating effect of hexametaphosphate on specific inorganic cholecystolith]. PMID- 4333963 TI - The early renal lesions of mice infected with encephalomyocarditis virus. PMID- 4333964 TI - Demonstration and purification of a specific antigen in Morris hepatoma 5123. PMID- 4333965 TI - Response of the rat kidney to folic acid administration. II. Morphologic studies. PMID- 4333966 TI - The bacterial cell surface. PMID- 4333967 TI - Immunoelectron microscopic studies of type C virus particles in ESP-1 and HEK-1 HRLV cell lines. PMID- 4333968 TI - Photoinduced free radicals of visual pigments in solutions mobile at--196 degrees C. PMID- 4333969 TI - Attempt to identify the agent for Creutzfeldt-Jakob disease by CF antibody relationship to known viruses. PMID- 4333970 TI - Metabolic transformation of Trypanosoma rhodesiense in culture. PMID- 4333971 TI - Spreading activation of end-plate receptors by single transmitter quanta. PMID- 4333972 TI - Pancreatic islet cell hyperplasia. A case report. PMID- 4333973 TI - [Importance of supraclavicular lymph nodes opacified during lymphography via the pedal route]. PMID- 4333974 TI - [Effect of ACTH administration on quantitative urinary excretion of a adrenocortical steroids in liver cirrhosis and in nephrotic syndrome]. PMID- 4333975 TI - Lithium studies and manic-depressive illness. PMID- 4333976 TI - Mechanism of cooperative oxygen binding to hemoglobin (spin-labeled triphosphate concerted transition model-hemoglobin chesapeake). AB - Evidence is presented that a generalized concerted transition model provides a quantitative understanding of (a) the molecular species that are present in solutions of partially liganded hemoglobin and (b) the macromolecular mechanism of cooperativity. Model parameters for hemoglobin A and for hemoglobin Chesapeake were determined from studies of the binding of spin-label triphosphates to ligand free and partially liganded hemoglobin solutions, and to the hybrids alpha(2) (+CN)beta(2) and alpha(2)beta(2) (+CN). This model is the same as that proposed originally by Monod, Wyman, and Changeux [J. Mol. Biol. (1965) 12, 88] for hemoglobin, except that the alpha-subunits are treated as nonequivalent to the beta-subunits. PMID- 4333977 TI - Acetoxycycloheximide-induced transient amnesia: protective effects of adrenergic stimulants. AB - It has previously been shown that rats trained 5 hr after intracerebral injection of acetoxycycloheximide show a transient amnesia at 24 hr after training. We have tested the possibility that adrenergic stimulants might provide protection from the amnesia. Metaraminol, given either before or after training or before testing, prevents the drug-induced amnesia. D-Amphetamine, injected soon after training, also prevents the amnesia. A model is presented to explain the drug induced amnesia in terms of both the assumed effect of acetoxycycloheximide on the adrenergic system and prevention of the amnesia by metaraminol and D amphetamine. PMID- 4333978 TI - Solubilization and partial purification of amino acid-specific components of the D-lactate dehydrogenase-coupled amino acid-transport systems (E. coli-cell membranes-sephadex-detergent-solubilized-vesicles). AB - A protein-containing fraction has been solubilized from E. coli ML 308-225 membrane vesicles that has many of the properties of the amino acid "carrier proteins" of the D-lactate dehydrogenase-coupled amino acid-transport systems. Membrane vesicles were partially solubilized with the nonionic detergent Brij 36 T, and the solubilized material was fractionated by Sephadex G-100 chromatography in the presence of the same detergent. Three fractions possess binding activity for proline: one of relatively low molecular weight with a high specific activity, and two of higher molecular weight with low specific activities. The higher molecular weight fractions exhibit D-lactate dehydrogenase activity; however, there is no corresponding activity associated with the low molecular weight fraction. Moreover, proline-binding activity is highly specific as it is not inhibited by structurally-unrelated amino acids. In addition to proline, the low molecular weight fraction exhibits binding activities for serine, glycine, lysine, and tyrosine. The proline-binding activity of the low molecular weight fraction is not inhibited by electron transfer or by general metabolic inhibitors that inhibit the accumulation of proline by intact membrane vesicles. In contrast, binding activity is inhibited by p-chloromercuribenzoate and N ethylmaleimide, and the inhibition observed with p-chloromercuribenzoate is reversed by the addition of dithiothreitol. The effect of these sulfhydryl reagents on binding corresponds to the effect of these compounds on proline transport by intact membrane vesicles. PMID- 4333979 TI - Activity of ribosomes containing 5S RNA with a chemically modified 3'-terminus. AB - Ribosomes containing 5S RNA in which the 3'-terminus has been modified chemically, either by periodate oxidation or by conversion of the terminal ribose to a morpholine derivative, are fully as active in peptidebond formation and polypeptide synthesis as those ribosomes with unmodified 5S RNA. These results exclude models for protein synthesis in which peptidyl-5S RNA is formed as an intermediate. PMID- 4333980 TI - Establishment of repression by lambdoid phage in catabolite activator protein and adenylate cyclase mutants of Escherichia coli. AB - Lambdoid phages form clear plaques and show reduced ability to establish immunity in strains of Escherichia coli that lack adenylate cyclase or catabolite activator protein. The absence of the activator protein or cyclic AMP reduces the frequency of lysogenization, but does not prevent steady-state repressor synthesis of a lysogen. Lambda phage mutants able to form turbid plaques on strains that lack catabolite activator protein or adenylate cyclase have been isolated and analyzed. PMID- 4333981 TI - Evidence for the presence of hydrogen-bonded secondary structure in angiotensin II in aqueous solution. AB - Automated tritium-hydrogen exchange measurements have been made on the linear octapeptide Val(5)-angiotensin II amide. All six amide hydrogens of the peptide backbone are observable, and are resolved into three classes according to their exchange rates. The rate of exchange of the slowest class, t(1/2) of 300 min at 0 degrees C (pH 2.5), is compared with that of hydrogens that exchange abnormally slowly in other peptides. It is concluded that these slow hydrogens in angiotensin II are involved in secondary structure with either one or both forming stable, intramolecular hydrogen bonds. This finding demonstrates that linear peptides may have hydrogen-bonded conformations in aqueous solutions. Analysis of the pH dependence of the rate of exchange indicates that one peptide amide hydrogen, namely that of the Asn(1)-Arg(2) peptide bond, is not involved in hydrogen bonding and is freely accessible to the solvent. Thus, the finding of internal hydrogen bonding, together with the assignment of the environment of one peptide bond, places major constraints on the number of allowable conformations of this linear polypeptide hormone. PMID- 4333982 TI - Epstein-Barr virus: transformation, cytopathic changes, and viral antigens in squirrel monkey and marmoset leukocytes. AB - Blood leukocytes of two species of new world primates, other than human, transform following exposure to Epstein-Barr virus. The transformed simian cells produce Epstein-Barr virus antigens and infectious (transforming) virus. The simian lymphoblastoid cells form multinucleate giant cells that appear to be selective sites for the production of Epstein-Barr virus. Multinucleate cells reveal intranuclear inclusions; in both species, a large proportion of giant cells contain Epstein-Barr virus antigen detectable by immunofluorescence. PMID- 4333983 TI - Affinity chromatography of RNA-dependent DNA polymerase from RNA tumor viruses on a solid phase immunoadsorbent. AB - A solid phase immunoadsorbent specific for RNA-dependent DNA polymerase from murine and feline RNA tumor viruses has been prepared. The enzymes from murine and feline virus but not from avian virus bind to columns of this material. Bound enzymes can be eluted in active form. This method has permitted selective purification of viral enzyme from crude extracts of virus-transformed cells, since the immunoadsorbent has no affinity for cellular DNA polymerases. PMID- 4333984 TI - The inhibition of plant and animal adenosine 3':5'-cyclic monophosphate phosphodiesterases by a cell-division-promoting substance from tissues of higher plant species. AB - One member of a new class of cell-division-promoting factors, that has been given the trivial name of cytokinesin I, is a potent inhibitor of adenosine 3':5' cyclic monophosphate phosphodiesterases of both plant and animal origin. Since an adenylate cyclase has been demonstrated in this study to be present in plant cells, the results suggest that cytokinesin I may be exerting its biological effects in promoting division in cells of higher plant species as a regulator of adenosine 3':5'-cyclic monophosphate. PMID- 4333985 TI - RNA in human leukemic cells related to the RNA of a mouse leukemia virus (leukocytes-RNA-DNA hybridization-rauscher virus-polysomal RNA). AB - Molecular hybridization with radioactively labeled DNA complementary to the RNA of the Rauscher leukemia virus was used to probe for homologous RNA in the polysome fraction of human leukemic cells. The leukocytes of 24 out of 27 patients examined contained RNA possessing homology to that of the mouse leukemia agent, but not to that of the unrelated viruses causing mammary tumors in mice or myeloblastosis in chickens. Further, no control human leukocytes or other adult and fetal tissues showed significant levels of the leukemia-specific RNA. It would appear that human leukemic cells contain RNA sequences homologous to those found in a viral agent known to cause leukemia in an experimental animal. The fact that human sarcomas have also been shown to contain this type of RNA points to a remarkable parallelism in the leukemias and sarcomas of mice and men. PMID- 4333986 TI - Expression of adenylate cyclase, catecholamine receptor, and cyclic adenosine monophosphate-dependent protein kinase in synchronized culture of Chang's liver cells (S phase-membrane receptors-NaF stimulation). AB - In Chang's liver cells synchronized by exposure to thymidine, both cyclic adenosine monophosphate-dependent and cyclic adenosine monophosphate-dependent and cyclic adenosine monophosphate-independent protein kinase activities increased throughout the cell cycle in a manner that corresponded approximately to the overall increase in cellular protein. Thus, the catalytic and the cyclic adenosine monophosphate-binding regulatory subunits of protein kinase appear to be temporally coexpressed. Adenylate cyclase activity stimulated by catecholamine, as well as basal activity, decreased markedly after release of cells from thymidine blockade during the S phase of the cell cycle; this was followed by recovery and overall net increase to fully expressed activity by the peak of mitosis. After initial decrease early in the S phase, cyclase activity assayed in the presence of fluoride ion began to rise before the rise in basal and catecholamine-stimulated activities, indicating that regulation of membrane receptors for catecholamines and for basal activity may be at least in part separate from that for catalytic activity of adenylate cyclase. The differential expression of membrane receptors for adenylate cyclase during the Chang's liver cell cycle affords a possible mechanism for control of response to hormones during the cell cycle. PMID- 4333987 TI - Regulation of adenosine 3',5'-cyclic monophosphate phosphodiesterase activity in fibroblasts by intracellular concentrations of cyclic adenosine monophosphate (3T3-dibutyryl cyclic AMP-SV40-transformed cells-michaelis constants-L cells prostaglandin E 1 ). AB - Cyclic AMP-phosphodiesterase is present in various mouse fibroblasts. Contact inhibited 3T3 cells contain two forms of the enzyme, one with a K(m) of 2.5 muM and the second with a K(m) of 71 muM. As 3T3 cells grow to confluency and cAMP concentrations rise, the activity of the first enzyme increases, whereas that of the second is unchanged. A line of SV40-transformed 3T3 cells with low cAMP concentration also has low levels of the cAMP-phosphodiesterase with a K(m) of 2.5 muM. Treatment of 3T3 and SV40-transformed 3T3 cells with dibutyryl cAMP and theophylline increases cAMP-phosphodiesterase accumulation. This accumulation is blocked by cycloheximide and actinomycin D. The newly formed enzyme resembles the higher affinity enzyme present in unstimulated cells, since it has a K(m) of 1.2 2.0 muM, and is stimulated by snake venom. In L cells in which cAMP concentrations are elevated by treatment with prostaglandin E(1), cAMP phosphodiesterase also accumulates. We conclude that intracellular concentrations of cAMP regulate the synthesis of cAMP-phosphodiesterase, and that cAMP functions as an inducer of the enzyme. PMID- 4333988 TI - Direct evidence for a prostaglandin receptor and its application to prostaglandin measurements (rat-adipocytes-antagonists-analogues-mouse ovary assay). AB - A prostaglandin receptor is present in rat adipocytes, as shown by competition studies with [(3)H]-prostaglandin E(1). The affinity of the E prostaglandins for this receptor preparation is greater than that of A and F prostaglandins, an observation consistent with their relative potencies in stimulating cyclic AMP formation in isolated mouse ovaries and various other organs. In the protocol described, binding constants of 3-8 nM were obtained with prostaglandins E(2) and E(1). A sensitivity of 1 pmole makes this method readily applicable for measurement of tissue concentrations of the E prostaglandins. PMID- 4333990 TI - [Granular cell myoblastoma. Clinical and histopathological study]. PMID- 4333991 TI - [Bone metastasis of primary of the liver carcinoma. (Apropos of 5 anatomoclinical cases)]. PMID- 4333992 TI - Electric enhancement of bone healing. AB - A human congenital pseudarthrosis of the tibia, unresponsive to conventional treatment, was stimulated to healing by direct electric current. The method was modeled after prior experimental work in vivo in rabbits. X-ray photographs, histological techniques, and electron microscopy confirmed the presence of newly formed bone in the defect region. PMID- 4333989 TI - Inhibition of release of dopamine- -hydroxylase and norepinephrine from sympathetic nerves by colchicine, vinblastine, or cytochalasin-B (hypogastric nerve stimulation-exocytosis-microtubules-microfilaments-guinea pig). AB - Stimulation of the hypogastric nerve to the guinea pig vas deferens in the presence of phenoxybenzamine produced an enhanced release of both dopamine-beta hydroxylase (EC 1.14.2.1) and norepinephrine. Addition of colchicine, vinblastine, or cytochalasin-B to the incubation medium caused an almost complete inhibition of release of both the amine and the enzyme. Colchicine and cytochalasin-B produced a blocking effect but did not, however, modify the ratio of dopamine-beta-hydroxylase to norepinephrine recovered in the bath fluid. The findings indicate that norepinephrine and dopamine-beta-hydroxylase are released from sympathetic nerve terminals by exocytosis and that this process is dependent upon the integrity of both microtubules and microfilaments. PMID- 4333993 TI - Isolated adrenal cells: adrenocorticotropic hormone, calcium, steroidogenesis, and cyclic adenosine monophosphate. AB - Corticosterone production by isolated adrenal cells in response to adrenocorticotropic hormone is reduced when the cells are incubated in a medium that contains no calcium. This reduction is associated with an equal reduction of accumulation of cyclic adenosine monophosphate. Production of corticosterone and accumulation of cyclic adenosine monophosphate are increased when the calcium concentration in the medium is increased (from zero to 7.65 millimolar). This is in contrast to the situation in "subcellular membrane fragments" of adrenal tissue where high calcium in the medium (> 1.0 millimolar) inhibits cyclic adenosine monophosphate accumulation. We propose that adenyl cyclase in the intact plasma membrane is located in a compartment wherein calcium concentration is low and remains unaffected by the concentration of calcium in the extracellular space. It is proposed that, as the concentration of calcium in the incubation medium is increased from zero to 7.65 millimolar, the strength of the signal generated by the interaction of adrenocorticotropic hormone with its receptor and transmitted to the adenyl cyclase compartment is proportionately increased. PMID- 4333994 TI - Intravascular degranulation of neutrophils: an important factor in inflammation? AB - Polymorphonuclear leukocytes are degranulated in the lumens of vessels in synovial membrane in humans with various types of inflammatory arthritis and in dogs with synovitis induced by urate crystals. This degranulation, accompanied by the release of lysosomal enzymes and vasoactive materials, may be an important part of the mechanism resulting in vascular injury. PMID- 4333995 TI - Synaptic transmission depressed by colchicine blockade of axoplasmic flow. AB - Colchicine, which inhibits axoplasmic transport and induces organelle alterations in nerve terminals, was injected intraocularly in pigeons. Electrical stimulation of the optic nerve yielded normal evoked potentials in retinotectal fibers, whereas postsynaptic responses recorded in the tectum were reduced. Postsynaptic depression suggests a deficit of synaptic transmission, presumably dependent on colchicine interference with migrating material. PMID- 4333996 TI - Theophylline preparations in the treatment of myasthenia gravis. PMID- 4333997 TI - Opsoclonus and body tremulousness: a case report with suggested cause. PMID- 4333998 TI - 6-hydroxy-dopamine induced chemonigrectomy and resultant sensorimotor impediment. PMID- 4334000 TI - Neuromuscular responses of the sloth. PMID- 4333999 TI - Synaptic preservation in old post x-irradiation lesions (EEG and electron microscope observation). PMID- 4334001 TI - Hypertrophic neuropathy with primary failure of peripheral myelination. PMID- 4334002 TI - Interrelationship between poliomyelitis and Toxocara infection. PMID- 4334003 TI - Some observations on the pathogenicity of strains of Entamoeba histolytica. PMID- 4334004 TI - Herpesviral isolates related to Marek's disease virus from chicken and turkey kidney cell cultures. PMID- 4334005 TI - Occlusion of the central retinal artery and retinal branch arterioles. A clinical, tonographic and fluorescein angiographic study of 175 patients. PMID- 4334006 TI - [Milk enzymes]. PMID- 4334007 TI - [Influence of contralateral narrow-band noise on the Bekesy tracings of normal listeners]. PMID- 4334008 TI - Alteration of the orbicularis oculi reflex by acoustic neuroma. PMID- 4334009 TI - Effects of lateral ampullary nerve section in squirrel monkeys. PMID- 4334010 TI - Regulation of glutamate dehydrogenases in Neurospora crassa as a response to carbohydrates and amino acids in the media. PMID- 4334011 TI - The primary structure of aspartate transfer ribonucleic acid from brewer's yeast. I. Complete digestion with pancreatic ribonuclease and T 1 ribonuclease. PMID- 4334012 TI - Rat liver and hepatoma ribosomal proteins two-dimensional polyacrylamide gel electrophoresis. PMID- 4334013 TI - Haemoglobin Bart's in newborn Nigerians. PMID- 4334014 TI - [Action of tryptophan on the A cells of the islands of Langerhans in guinea pigs on a low-protein diet]. PMID- 4334015 TI - [Antibiotics and blood coagulation in vitro]. PMID- 4334017 TI - [Rabbit immunization against angiotensin. II. Comparison between different methods]. PMID- 4334016 TI - [Ultrastructural study in Wistar rats of lymph node behavior in tumoral invasion. I. Cell reactions towards the introduction of soluble antigens in inexperienced animals]. PMID- 4334018 TI - [Demonstration of a plasma factor binding angiotensin. II]. PMID- 4334019 TI - [Elaboration of a program for automatic analysis and quantification of the different phases of wakefulness and sleep in rats]. PMID- 4334020 TI - The effect of natural and synthetic vasopressins and other substances on active transport in ciliary epithelium of the rabbit. PMID- 4334021 TI - Ultrastructural studies on the effect of choline orotate on galactosamine induced hepatic injury in rats. PMID- 4334022 TI - The maintenance of mitochondrial size in the rat adrenal cortex zona fasciculata by ACTH. PMID- 4334023 TI - [Unusual symptoms of a disgerminoma with special histologic and endocrine manifestations. "Malignant germinothecoma"]. PMID- 4334024 TI - [Current status of our knowledge of fetal electroencephalography (F.E.E.G.)]. PMID- 4334025 TI - Free radicals in a single crystal of glycyl-glycine at room temperature. PMID- 4334026 TI - A computer-controlled E.P.R. analysis of free radical formation in dry thymine and derivatives after electron irradiation. PMID- 4334027 TI - Natural population dynamics of phlebotomine sandflies in Panama. PMID- 4334028 TI - The origin of blood meals of female Culicoides pallidipennis trapped in a sheepfold in Israeil. PMID- 4334029 TI - Presidential address. Cytogenesis and differentiation of primitive central neuroepithelial tumors. PMID- 4334030 TI - A case of Clostridium perfringens endocarditis. PMID- 4334031 TI - [Arterial hypertension and oral contraceptives]. PMID- 4334032 TI - Surface glycoproteins and glycolipids of chicken embryo cells transformed by a temperature-sensitive mutant of Rous sarcoma virus. PMID- 4334033 TI - Cyclic 3', 5'-AMP and theophylline inhibit epidermal mitosis in G2-phase. PMID- 4334034 TI - [Postsynaptic potentials of the cat auditory cortical neurons]. PMID- 4334035 TI - [Responses of orbitofrontal cortical neurons to stimulation of the thalamic nuclei]. PMID- 4334036 TI - [Change in the reactions of visual cortical neurons to light flashes during hypothalamic and reticular stimulation]. PMID- 4334037 TI - [Functional changes in neurosecretory cells of the anterior hypothalamic nuclei during stimulation of the midbrain reticular formation]. PMID- 4334038 TI - [Reticulospinal and vestibulospinal synaptic effects on monkey lumbar motor neurons]. PMID- 4334039 TI - [Synaptic effects of contralateral somatic afferents on spinal motor neurons]. PMID- 4334041 TI - Treatment of nasopharyngeal angiofibroma. PMID- 4334040 TI - [Characteristics of orthodromic inhibition in neuron-pacemakers of Helix pomatia]. PMID- 4334042 TI - The routine use of subtraction in aortic arch studies. PMID- 4334043 TI - Aneurysms of the internal carotid artery in the carotid canal of the petrous temporal bone. PMID- 4334044 TI - [Neurological aspects of histiocytosis X]. PMID- 4334045 TI - [Coma with lethal outcome in nesidioblastoma (malignant insuloma)]. PMID- 4334046 TI - [Pancreatoduodenal resection in rare forms of tumors of the head of the pancreas]. PMID- 4334047 TI - Percutaneous double catheter infusion technique for the treatment of carcinoma in the abdomen. PMID- 4334048 TI - Clinical experience with hepatic adenomas. PMID- 4334049 TI - Isolation of infectious bovine rhinotracheitis virus in Tanzania. PMID- 4334050 TI - [Grounds for radical surgery in thyroid gland cancer]. PMID- 4334051 TI - Neonatal calf diarrhea: results of a field trial using a reo-like virus vaccine. PMID- 4334052 TI - The embryonic and postnatal development of the inner ear of the mouse. PMID- 4334053 TI - Water vapour transmission through free films of hydroxypropyl cellulose. PMID- 4334055 TI - Carbohydrate metabolism of heat-acclimated hamsters. 3. Control of liver glucose 6-phosphatase. PMID- 4334054 TI - Excitation of intestinal muscle by atropine, tetrodotoxin, and xylocaine. PMID- 4334056 TI - Plasma renin activity in varying hydrated states in the bullfrog. PMID- 4334057 TI - Effects of temperature at the neuromuscular junction. PMID- 4334058 TI - Effects of aldosterone and vasopressin on adenyl cyclase activity of rat kidney. PMID- 4334060 TI - A multifocal diffuse glomus tumor: case report and review of the literature. PMID- 4334059 TI - Effect of mercuric chloride on plasma renin substrate level in rats. PMID- 4334061 TI - [Histological studies on trophoblastic giant cells in sheep pacentoma]. PMID- 4334062 TI - Unscheduled DNA synthesis, u.v.-induced chromosome aberrations and SV 40 transformation in cultured cells from xeroderma pigmentosum. PMID- 4334063 TI - [Electron microscopic study of transmissible sarcomas in dogs]. PMID- 4334064 TI - [Glomus-angioma of the stomach]. PMID- 4334065 TI - [Cylindroma of the skin (histological and cytological picture)]. PMID- 4334066 TI - [Some aspects and specifics of cytophotometry of DNA in tumors]. PMID- 4334067 TI - Influence of storage, preservatives, methods of preparation, and routes of inoculation on infectivity of T-virus in chicks. PMID- 4334068 TI - Avian encephalomyelitis virus. I. Pathogenesis in chicken embryos. PMID- 4334069 TI - Avian encephalomyelitis virus. II. Pathogenesis in chickens. PMID- 4334070 TI - Bacteriological studies of fatal Clostridium perfringens type-A infection in chickens. PMID- 4334071 TI - Depression of thymus-and bursa-dependent immune systems chicks with Marek's disease. PMID- 4334073 TI - Studies of laryngotracheitis virus in avian tissue cultures. V. Growth characteristics of the virus in chicken kidney and chicken embryo kidney tissue cultures. PMID- 4334072 TI - Correlation of immunological competence with lesions in selected lymphoid tissues from chickens with Marek's disease. PMID- 4334074 TI - Influence of natural exposure on response to subsequent challenge with virulent Marek's disease virus. PMID- 4334075 TI - The temporal relationship between vaccination with the herpesvirus of turkeys and challenge with virulent Marek's disease virus. PMID- 4334076 TI - Avian reticuloendotheliosis virus (strain T). I. Virological characterization. PMID- 4334077 TI - Avian reticuloendotheliosis virus (strain T). II. Biochemical and biophysical properties. PMID- 4334078 TI - Avian reticuloendotheliosis virus (strain T). IV. Infectivity and transmissibility in day-old cockerels. PMID- 4334079 TI - An antigen used in the agar-gel precipitin reaction to detect avian encephalomyelitis virus antibodies. PMID- 4334080 TI - Reliability of the agar-gel precipitin test in Marek's disease studies. PMID- 4334081 TI - Twenty-five years of medical virology. PMID- 4334083 TI - [Interaction of hormonal and non-hormonal factors in the renal control of sodium and water balance and in the pathogenesis of edema]. PMID- 4334082 TI - Relation between content and composition of coalworkers' lungs and radiological appearances. PMID- 4334084 TI - Low dosage methotrexate (NSC-740) and cyclophosphamide (NSC 26271) for solid tumors. PMID- 4334085 TI - Microculture of human brain tumors. PMID- 4334086 TI - Clinical trials with the antitumor agent 5-(3,3-dimethyl-1-triazeno)imidazole-4 carboxamide(NSC-45388). PMID- 4334087 TI - Clinical trial of acetylenic carbamate: 1,1-diphenyl-2-propynyl cyclohexanecarbamate (NSC-112682). PMID- 4334088 TI - Clinical experience with mitomycin C (NSC-26980). PMID- 4334089 TI - 1,3-bis (2-chloroethyl)-1-nitrosourea (NSC-409962) in the treatment of brain tumors. PMID- 4334090 TI - Nephrotoxicity of streptozotocin (NSC-85998). PMID- 4334091 TI - ACTH, GH, prolactin, and -MSH activities of six kinds of cells isolated from the rat adenohypophysis. PMID- 4334092 TI - On the hypocalcemic effect in rabbits of a bovine parotid extract (parotin). PMID- 4334093 TI - A simple method for the preparation of ACTH responsive isolated cells from rat adrenals. PMID- 4334094 TI - The cardiac auto-immune system. V. Human heart antigens cross-reactive with rabbit anti-rabbit heart auto-antibodies. PMID- 4334095 TI - Interference contrast microscopy of living human oocytes. PMID- 4334096 TI - Stoichiometric composition of whitlockite. PMID- 4334097 TI - Lasting biological effects of early environmental influences. VII. Metabolism of adenosine in mice exposed to early environmental stress. AB - The metabolism of adenosine 3',5'-monophosphate (cyclic AMP) was studied in specific pathogen-free mice exposed to neonatal infection with mouse enterovirus or to malnutrition during early life. Metabolic activity was determined by measuring the turnover of cyclic AMP-8-(14)C to respiratory (14)CO(2), its incorporation into various organs and plasma, and the binding activity of synaptosome for cyclic AMP. Early malnutrition increased the catabolism of cyclic AMP as measured by expiration in respiratory CO(2). The level of cyclic AMP was lower in plasma and its incorporation into various tissues was decreased in infected and malnourished animals. Metabolic products of cyclic AMP were isolated from plasma by ion exchange chromatography. Cyclic AMP-8-(14)C had completely disappeared 9 hr after injection. Fewer metabolites of cyclic AMP were detected in infected or malnourished groups than in controls and the metabolic reaction from 5'-AMP to adenosine seemed to be slow in these animals. The ability to incorporate cyclic AMP to synaptosome was also impaired in the experimental groups. The concentrations of brain cyclic AMP were lower in infected or malnourished animals than in controls. Depression of accumulation of cyclic AMP probably resulted from excessive activity of phosphodiesterase, rather than from impairment of adenyl cyclase. Intraperitoneal administration of theophylline brought the activity level of phosphodiesterase to normal in infected or malnourished mice; this fact probably accounted for enhanced accumulation of brain cyclic AMP. PMID- 4334099 TI - Effects of chlorpromazine on the chromatophores of frog skin. PMID- 4334098 TI - Quantitative studies of naturally occurring murine leukemia virus infection of AKR mice. AB - Quantitative studies were made of the organ distribution of murine leukemia virus in AKR mice of various ages. Infectious virus first appeared shortly before or after birth and was continuously present in all mice thereafter. Highest infectivity titers were found in uterus and bone, with spleen slightly lower. Virus titers in normal thymus were relatively low, but increased significantly with the development of thymic lymphoma. The level of viremia decreased after the 1st month of life, but increased sharply in lymphomatous mice. PMID- 4334100 TI - [Cyclic adenosine monophosphate in the clinical picture and biochemistry of cellular processes, immune reaction, and cancerogenesis]. PMID- 4334101 TI - X-ray diffraction and fine structural studies of crystals in the malpighian tubules of silkworms. PMID- 4334102 TI - [Surgical alternatives in the treatment of so-called occult or hidden hypoglycemic insulomas]. PMID- 4334103 TI - [Experimental research on transplantation of the adrenal gland. II. Homotransplants]. PMID- 4334104 TI - [Benign tumor of the esophageal wall]. PMID- 4334105 TI - [Small cancer in an esophageal diverticulum]. PMID- 4334106 TI - [Double esophageal and gastric tumoral lesion: staggered leiomyosarcoma?]. PMID- 4334107 TI - [A case of granuloma on a gastroesophageal suture after upper polar gastrectomy]. PMID- 4334108 TI - [Menetrier's disease revealed by a digestive hemorrhage]. PMID- 4334109 TI - [Benign ulcer of the anterior face of the gastric body associated with benign and latent schwannoma of the posterior face of the gastric body]. PMID- 4334110 TI - [Benign giant ulcers of the lesser curvature]. PMID- 4334111 TI - [Ulcero-hemorrhagic lymphocytic lymphosarcoma of the stomach]. PMID- 4334112 TI - [Ulcer of the bulb simulating a benign duodenal tumor]. PMID- 4334113 TI - [Primary cancer of the 3d duodenal segment associated with a cancer of the 3d jejunal loop]. PMID- 4334114 TI - [Diagnostic value of duodenoscopy in Vater's ampulloma. Apropos of a case]. PMID- 4334115 TI - [Tuberculosis with multiple localizations]. PMID- 4334116 TI - [Isolated lesion of Bauhin's valve: Crohn's disease?]. PMID- 4334117 TI - [Sigmoid epithelioma undiagnosed for a year and a half. Elimination of a tumor fragment]. PMID- 4334118 TI - [History of the migration of a vesicular calculus toward the duodenum or the inopportuneness of conservation to excess]. PMID- 4334119 TI - [Cholecystoduodenal fistula]. PMID- 4334120 TI - [The uselessness of peroperative radiomanoflowmetry if the data of this examination are not taken into account]. PMID- 4334121 TI - [Cirrhosis with portal hypertension and hypersplenism: angiologic study preparatory to spleno-renal shunt]. PMID- 4334122 TI - [Triple association (hepatic adenoma, splenic angioma and lithiasis) simultaneously complicated by hemoperitoneum and angiocholitis]. PMID- 4334123 TI - [Malignant schwannoma of the gastrosplenic epiploon]. PMID- 4334124 TI - [Left ileo-pelvic tumor]. PMID- 4334126 TI - [The use of angiography in the study of fibroangiomas of the rhinopharynx]. PMID- 4334125 TI - [Effect of paranephral administration of novocaine on kidney metabolism in post transfusion complications]. PMID- 4334128 TI - Carcinoma of the endometrium. PMID- 4334127 TI - An analysis of hospitalizations for acute respiratory disease in recruits immunized with adenovirus type 4 and type 7 vaccines. PMID- 4334129 TI - Changes in the allantoic fluid composition during the development of the chicken embryo. Influence of some factors on the viability of Trypanosoma brucei. PMID- 4334130 TI - [Comparison of ifosfamid with cyclophosphamide in the therapy of rat DS carcinosarcoma]. PMID- 4334131 TI - [Experimental studies on the cancerogenicity of Penicillium camemberti var. candidum]. PMID- 4334132 TI - Studies on growth hormone secretion. 3. Inhibition of prostaglandin, theophylline and cyclic amp stimulated growth hormone release by valinomycin in vitro. PMID- 4334133 TI - Pseudouridine kinase of escherichia coli: a new enzyme. PMID- 4334134 TI - Dissociation and concomitant activation of adenosine 3',5'-monophosphate dependent protein kinase by histone. PMID- 4334135 TI - Insulin-receptor interactions in liver cell membranes. PMID- 4334136 TI - Insolubilized coenzymes: the covalent coupling of enzymatically active NAD to glass surfaces. PMID- 4334137 TI - Respiration dependent transport of proline by electron transport particles from mycobacterium phlei. PMID- 4334139 TI - Cytochalasin B inhibits thyroid secretion. PMID- 4334138 TI - Human erythrocyte membrane glycoprotein: a re-evaluation of the molecular weight as determined by SDS polyacrylamide gel electrophoresis. PMID- 4334140 TI - Size heterogeneity of immunoreactive human ACTH in plasma and in extracts of pituitary glands and ACTH-producing thymoma. PMID- 4334142 TI - EPR spectral observations on the binding of ATP and F-actin to spin-labeled myosin. PMID- 4334141 TI - EPR detectable electron acceptors in submitochondrial particles from beef heart with special reference to the iron-sulfur components of DPNH-ubiquinone reductase. PMID- 4334143 TI - Different effects of oligomycin and dicyclohexylcarbodiimide on ATPases from mammalian cells. PMID- 4334144 TI - Alterations of Forssman-antigenic reactivity and of monosaccharide composition in plasma membrane from polyoma-transformed hamster cells. PMID- 4334145 TI - Correlations between structure and spectroscopic properties in membrane model systems. Fluorescence of dansylated protein and dansylated lipid in protein-lipid water phases. PMID- 4334146 TI - Proton binding by phosphatidyl inositol in aqueous dispersion. PMID- 4334147 TI - Phosphate transport in Escherichia coli. PMID- 4334148 TI - Exchangeability of chloride in Ehrlich ascites tumor cells. PMID- 4334149 TI - The behavior of isolated zymogen granules: pH-dependent release and reassociation of protein. PMID- 4334150 TI - On the reaction sequence of the K + -dependent acetyl phosphatase activity of the Na + pump. PMID- 4334151 TI - A comparative study of cholesterol and a cholesterol-like ESR probe in pure and mixed monomolecular films. PMID- 4334152 TI - Effect of hypertonic media on the reversal of the hydrosmotic action of antidiuretic hormone in frog urinary bladder. PMID- 4334153 TI - Experimental zosteriform herpes simplex virus infection in mouse skin. PMID- 4334154 TI - The control of glycogen utilization in skin; phosphorylase B kinase and phosphorylase A phosphatase. PMID- 4334155 TI - Mathematical biophysics of sustained nonperiodic oscillations of excitation and inhibition in the central nervous system. PMID- 4334156 TI - Suggestions for a mathematical biology of some pathological phenomena in the central nervous system, with special reference to some epilepsies. PMID- 4334157 TI - The solid state physical theory of cytochrome oxidase kinetics. Inhibition of second order rate constant, and second to first order kinetic shift with increasing oxygen, predicted from electron injection and tapping. PMID- 4334158 TI - The distribution of red cells in the spleen. PMID- 4334159 TI - Circulating adrenocorticotropin (ACTH) as a controlled variable in the regulation of ACTH secretion. PMID- 4334160 TI - Duration of action of two "long-acting" adrenocorticotropin preparations in the rat. PMID- 4334161 TI - Treatment of Hodgkin's disease and other cancers with 1,3-bis(2-chloroethyl)-1 nitrosourea (BCNU; NSC-409962). PMID- 4334162 TI - Cardiovascular effects of angiotensin mediated by the central nervous system. PMID- 4334164 TI - [Our research results in stomatologic oncology]. PMID- 4334163 TI - Inhibition of converting enzyme of the renin-angiotensin system in kidneys and hindlegs of dogs. PMID- 4334165 TI - [Radiospectroscopic and histoenzymatic studies of animal tissues during intravenous anesthesia]. PMID- 4334166 TI - [The functional state of the pituitary-adrenal system in carcinoma of the cervix]. PMID- 4334167 TI - [Activity and localization of hydrolytic enzymes in the developing human placenta]. PMID- 4334169 TI - Sensitivity to antibiotics of gram-negative pathogens isolated from hospitalized patients having disseminated malignant disease. PMID- 4334168 TI - Adrenal function in cancer: relation to the evolution. PMID- 4334170 TI - Metabolic controls in precancerous liver: defective control of cholesterol synthesis in rats fed N-2-fluorenylacetamide. PMID- 4334171 TI - Competative antagonism of 8-ala-angiotensin II to angiotensins I and II on isolated rabbit aorta and rat colon. PMID- 4334172 TI - Effects of caerulein and pancreozymin on insulin secretion in normal subjects and in patients with insuloma. PMID- 4334173 TI - The hypothalamic-pituitary-adrenal function in children with severe cerebral lesions: an evaluation. PMID- 4334174 TI - Ultrastructural localization of glucose-6-phosphatase activity in proximal convoluted tubule cells of rat kidney. PMID- 4334175 TI - Gastrointestinal cancer in Iran. PMID- 4334176 TI - Rubella vaccine myeloradiculoneuritis. PMID- 4334178 TI - Cytosine arabinoside in the treatment of congenital cytomegalic inclusion disease. PMID- 4334179 TI - Editorial comment: antiviral chemotherapy. PMID- 4334177 TI - Experimental use of cytosine arabinoside in congenital cytomegalovirus infection. PMID- 4334180 TI - Peripheral pain syndromes following rubella immunization. PMID- 4334181 TI - [Estrogen therapy in ophthalmology with special reference to the therapy of diabetic retinopathies]. PMID- 4334182 TI - Wilm's tumour. PMID- 4334183 TI - [Factors that affect the formation of infective plaque formation with herpes simplex virus in the absence of CO 2 ]. PMID- 4334184 TI - Management of chronic and recurrent gout. PMID- 4334185 TI - Nongouty crystal deposit arthritis. PMID- 4334186 TI - The internist's role in the management of cancer. PMID- 4334187 TI - Economic loss from an acute IBR outbreak in a dairy herd. PMID- 4334188 TI - Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 12-1972. PMID- 4334189 TI - Increased incidence of Rous sarcomas in response to excess vitamin A. PMID- 4334190 TI - Stress, fighting and neuroendocrine function. PMID- 4334191 TI - Revised amino-acid sequences for porcine and human adrenocorticotrophic hormone. PMID- 4334192 TI - Changes in infrared spectrum of nerve during excitation. PMID- 4334193 TI - In vitro synthesis of DNA complementary to rabbit reticulocyte 10S RNA. PMID- 4334195 TI - Agglutination of normal and rous sarcoma virus-transformed chick embryo cells by concanavalin A and wheat germ agglutinin. PMID- 4334194 TI - In vitro synthesis of DNA components of human genes for globins. PMID- 4334196 TI - Expression of a new complement-fixing antigen reactive with murine sarcoma virus rat antiserum in rat cells transformed by polyoma virus. PMID- 4334197 TI - [The significance of conditionally pathogenic intestinal flora in young children]. PMID- 4334198 TI - [Current methods of studying absorption processes]. PMID- 4334200 TI - Concentration of virus from water by electro-osmosis and forced-flow electrophoresis. PMID- 4334199 TI - Ultradian rhythms in human performance. PMID- 4334201 TI - [Pertussis and parapertussis antibody levels in selected groups of children and adolescents]. PMID- 4334202 TI - The role of vitamin D and its relationship to parathyroid hormone and calcitonin. PMID- 4334203 TI - Production and secretion of testicular steroids. PMID- 4334204 TI - Analysis of the response to ACTH by rat adrenal in a flowing system. PMID- 4334205 TI - [Case of renovascular hypertension with jet-type renal aneurysm--with special reference to the observation on dynamics of electrolytes, and renin angiotensin aldosterone system before and after treatment]. PMID- 4334206 TI - [Role of cyclic adenosine monophosphate (cAMP) in living organisms]. PMID- 4334207 TI - [Etiopathogenesis of thrombotic disease]. PMID- 4334208 TI - The effect of a noradrenaline liberator (4, alpha-dimethyl-meta-tyramine) on reflex transmission in spinal cats. PMID- 4334209 TI - Influence of synthesis and membrane pump inhibition on the nerve impulse induced disappearance of noradrenaline from rat salivary glands. PMID- 4334210 TI - A possible explanation for the gastrointestinal mucosal lesion in immunoglobulin deficiency state. PMID- 4334211 TI - Chronic amebiasis. A clinical syndrome? PMID- 4334212 TI - Pregnancy and toxic dilatation of the colon. PMID- 4334213 TI - Surgical correction of functioning islet cell carcinoma of the pancreas associated with hyperadrenocorticism. PMID- 4334214 TI - The radiology corner. Reversibility in granulomatous colitis. PMID- 4334215 TI - Changes in the alveolar lining with onset of breathing. AB - Changes in the alveolar lining of newborns were investigated by sacrificing rabbits at birth and at intervals shortly after birth, and examining their lungs in the electron microscope. An orderly, reproducible sequence of changes in the Type II alveolar lining cells and alveolar space was demonstrated, and the observations correlated well with biochemical events. Type II cell inclusions, dense and numerous at birth, enlarged and became less dense ((1/2)-1 hour), appeared to empty their contents into the alveolar space and disappear (1(1/2) hours) and then reappeared with a mixture of sizes and densities in each cell (2 hours). Few lamellar figures were present in the alveolus at birth, the number reaching a maximum at 1(1/2) hours and then decreasing. The first evidence of a noncellular alveolar lining was at 1(1/2) hours, when lamellar figures and granular material adhered to small corners of the alveolar wall. At 2(1/2) hours, a thick dense layer covered much of the wall. At 6 hours, the layer was thinner and denser, and at 24 hours the thin osmiophilic surfactant lining was present. PMID- 4334217 TI - Simple device for transferring and eluting thin-layer chromatographic fractions. PMID- 4334216 TI - Effect of staphylococcal alpha-toxin on the fine structure of pancreatic acinar cells of dogs. AB - Staphylococcal alpha-toxin induced pancreatitis in dogs was studied by electron microscopy. Pancreatic acinar cell injury was indicated by increased vesiculation of endoplasmic reticulum, loss of intracisternal granules, changes in mitochondria, membrane discontinuities and an increased number of dense complex bodies, lipid droplets and free ribosomes. PMID- 4334219 TI - Addendum: a warning an accurate and convenient organic phosphorus assay. PMID- 4334218 TI - Analysis of adenine nucleotides and metabolic intermediates in mature and senescent leaf tissue. PMID- 4334220 TI - Radioimmunoassay of cyclic AMP without precipitating antibody. PMID- 4334221 TI - Separation of phosphatidylserine and -inositol by one-dimensional thin-layer chromatography of lipid extracts. PMID- 4334222 TI - [Comparative biochemical study on the diabetogenic effect of streptozotocin in mice, rats, Chinese hamsters and guinea pigs]. PMID- 4334223 TI - [Formation of carcinogenic nitroso compounds in the stomach of laboratory animals and their significance for man. 2]. PMID- 4334224 TI - [Thin-layer chromatography of alkylating compounds with 4-(4'-nitroboenzyl) pyridine (NBP)]. PMID- 4334225 TI - Activation of microsomal glucose-6-phosphatase and associated pyrophosphatase and pyrophosphate-glucose phosphotransferase activities of human liver by aluminum oxide. PMID- 4334226 TI - Cyclic 3 ', 5 '-nucleotide phosphodiesterase. Effect of divalent cations. PMID- 4334228 TI - Role of dehydrogenase binding in protection of nicotinamide adenine dinucleotide from enzymatic hydrolysis. PMID- 4334227 TI - Adenyl cyclase from renal cortex. PMID- 4334229 TI - Effects of monovalent cations and ATP on brain thiamine diphosphatase of normal rats. PMID- 4334230 TI - [Effect of excitation propagation velocity on the working regime of a neuron ensemble]. PMID- 4334231 TI - [Study of actin polymerization by the method of paramagnetic labels]. PMID- 4334232 TI - [Measurement of the distance between paramagnetic centers in solid solutions of nitrosyl radicals, biradicals and spin-labelled proteins]. PMID- 4334233 TI - [Possible determination of distances between functional groups in proteins by the method of paramagnetic labels]. PMID- 4334235 TI - Malignant mixed mullerian tumors of the uterus. PMID- 4334234 TI - Carcinoma of the breast during estrogen replacement therapy. PMID- 4334236 TI - Antibody to Herpesvirus hominis types 1 and 2 in patients with Hodgkin's disease and carcinoma of the nasopharynx. PMID- 4334238 TI - Diagnosis of occult Zollinger-Ellison tumors by gastrin radioimmunoassay. PMID- 4334237 TI - Antibodies to herpes-type virus in nasopharyngeal carcinoma and control groups. PMID- 4334239 TI - Ultrastructural and biochemical correlates of adrenal and extra-adrenal pheochromocytoma. PMID- 4334240 TI - Pneumocystis carinii in children with malignant disease. PMID- 4334241 TI - Embryonal rhabdomyosarcoma of the middle ear. PMID- 4334242 TI - Carcinomas with trophoblastic differentiation and secretion of chorionic gonadotrophins. PMID- 4334243 TI - The use of average cerebral evoked potentials in the evaluation of sensory loss in forensic medicine. PMID- 4334244 TI - [Evaluation of sensory disorders in the lower limb]. PMID- 4334245 TI - Relationship between lactic dehydrogenase activity and other enzyme activities of human seminal plasma. PMID- 4334246 TI - Sudden death from noninsulin secreting islet cell tumor of the pancreas ("glucagonoma"). PMID- 4334247 TI - Epithelioid sarcoma. A clinical and pathologic study of nine cases. PMID- 4334248 TI - Differences in properties of newly formed collagen during aging and parabiosis. PMID- 4334249 TI - The effect of repeated blood meals infective for bluetongue on the infection rate of Culicoides variipennis. PMID- 4334250 TI - Subcellular fractionation of cultured glial cells. PMID- 4334252 TI - The classification of dusts which cause pulmonary disability. PMID- 4334251 TI - Cadmium nephropathy: ultrastructural observations (horseradish peroxidase). PMID- 4334254 TI - Cyclic AMP phosphodiesterase and its inhibitor in slime mould development. PMID- 4334255 TI - [Virological studies of the central nervous system of horse fetuses and findings in mares suffering from central nervous system disease following abortion caused by equine herpesvirus 1]. PMID- 4334253 TI - Effect of amitriptyline on lipolysis and cyclic AMP concentration in isolated fat cells. PMID- 4334256 TI - [Determination of the inhibitory activity of some new substituted theophyllines on the specific phosphodiesterase of cyclic nucleotides]. PMID- 4334257 TI - Serological studies in an epidemic of jaundice in Nigeria. PMID- 4334258 TI - Toxoplasmosis in tropical Africa. PMID- 4334259 TI - The association of a herpesvirus with generalised disease in a kitten. PMID- 4334260 TI - Experimental vaccinia infection of cattle: a comparison with other virus infections of cows' teats. PMID- 4334261 TI - [Clinical picture and therapy of multiple sclerosis]. PMID- 4334262 TI - [Metabolism of Tetrahymena pyriformis during the ingestion of indigestible parcticles]. PMID- 4334264 TI - Characterization of collagen biosynthesis in rabbit dental pulp in vitro. PMID- 4334263 TI - The cytoplasmic inclusions of the salamander oocyte. 3. Lipochondria. PMID- 4334265 TI - The function of the dream: a reappraisal. PMID- 4334266 TI - Collateral arterial blood supply of the liver after hepatic artery ligation, angiographic study of twenty patients. PMID- 4334267 TI - Metabolic and ultrastructural studies in a patient with pustular psoriasis (von Zumbusch). PMID- 4334268 TI - Ultrastructural study of a case of extramammary Paget's disease of the vulva. PMID- 4334269 TI - Calcium stimulated ATP-ASE of cardiac sarcolemma. PMID- 4334270 TI - Infectious low-molecular weight ribonucleic acid from tomato. PMID- 4334271 TI - Cyclic adenosine 3':5'-monophosphate and microtubule function: specific interaction of the phosphorylated protein subunits with a soluble brain component. PMID- 4334272 TI - Stimulation by arsenate of ATP-driven energy-linked reduction of NAD + by succinate. PMID- 4334273 TI - The effect of prostaglandins on cyclic AMP production and cell proliferation in thymic lymphocytes. PMID- 4334274 TI - Cyclic AMP levels in fibroblasts: relationship to growth rate and contact inhibition of growth. PMID- 4334275 TI - Evidence of heme-heme interaction in heme-spin-labeled hemoglobin. PMID- 4334277 TI - Phosphoinositide interconversion: a model for control of Na + and K + permeability in the nerve axon membrane. PMID- 4334276 TI - Stimulation of rat liver lysosomal lipase by lipid and by acidic phospholipids. PMID- 4334278 TI - Structural changes in the phospholipid regions of the axonal membrane produced by phospholipase C action. PMID- 4334279 TI - Effect of substrate structure on the rate of the catalytic step in the liver alcohol dehydrogenase mechanism. PMID- 4334280 TI - Kinetics of carbonic anhydrase-inhibitor complex formation. a comparison of anion and sulfonamide-binding mechanisms. PMID- 4334281 TI - Purification and some properties of a protein containing bound manganese (avimanganin). PMID- 4334282 TI - Properties of a collagen molecule containing three identical components extracted from bovine articular cartilage. PMID- 4334283 TI - Yeast diphosphopyridine nucleotide specific isocitrate dehydrogenase. Purification and some properties. PMID- 4334284 TI - Yeast diphosphopyridine nucleotide specific isocitrate dehydrogenase. Binding of ligands. PMID- 4334286 TI - Hypusine, a new amino acid occurring in bovine brain. Isolation and structural determination. PMID- 4334285 TI - Mass spectrometry of trifluoroacetyl derivatives of nucleosides and hydrolysates of deoxyribonucleic acid. PMID- 4334289 TI - Synaptic organization in the olfactory glomerulus of the mouse. PMID- 4334288 TI - Glutamic acid as a synaptic transmitter in the nervous system. A review. PMID- 4334290 TI - A controlled field study using live virus vaccines and an antiserum in a preconditioning program. AB - Thirty-five vaccinates and 29 control beef calves from five farms were studied. Vaccinates in group 1 received a modified live virus vaccine against infectious bovine rhinotracheitis (IBR) and bovine virus diarrhea (BVD) 30 days after shipment; vaccinates in groups 2, 3 and 4 received live virus vaccines agains IBR and bovine parainfluenza 3 (PI3) seven to 17 days before shipment. Half of group 5 were given bovine origin antiserum containing antibodies against IBR, BVD and PI3. Three weeks later, the animals that had received serum were given a live modified vaccine containing IBR, BVD and PI3. In group 1, WBC counts were lower in the vaccinates than in the controls for two weeks after vaccination. WBC counts in groups 3 and 4 were higher in vaccinates than in controls after addition to the feedlot. Seroconversions to BVD virus occured in all groups. Clinical disease apparently due to BVD affected one vaccinated calf in group 2 and eight calves in group 5. Combined weight gains were significantly higher in three groups of calves vaccinated before shipment compared to unvaccinated control animals after addition to the feedlot. Vaccination with IBR and PI3 live virus vaccines should be given at least 17 days before shipment to feedlots containing infected cattle. Antiserum containing antibodies against the three viruses showed no apparent advantage in preventing clinical respiratory disease over control calves not receiving the serum. PMID- 4334287 TI - Role of a regulating protein and molecular oxygen in the mechanism of action of luteinizing hormone. PMID- 4334292 TI - Renal adenocarcinoma with intranuclear inclusions in an Arctic ground squirrel. PMID- 4334291 TI - Heterogeneity of foot-and-mouth disease virus: further studies on plaque formation by two plaque-size variants. AB - Plaque production by a small-plaque (SP) and large-plaque (LP) variant of foot and-mouth disease virus, type A, strain 119 (FMDV, A119), was influenced by a number of environmental factors. The SP variant produced plaques on cells of the IB-RS-2 cell line from swine kidney and to a lesser degree on primary cultures of swine kidney cells, but plaque formation was inhibited on primary cultures of bovine kidney (BK) cells unless diethylaminoethyl (DEAE) dextran was added to agar overlays. When DEAE dextran-treated agar overlay was used, the LP variant formed larger plaques on BK cells but not on IB-RS-2 cells. Concentrations of DEAE dextran from 0 to 100 microg/ml greatly enhanced the formation of SP virus plaques on BK cells but had little or no effect on the average size of plaques produced by the LP variant. Higher concentrations of polycation enlarged the plaques formed by both variants. Plaque sizes of the SP and LP variants increased as the concentration of agar or agarose in the overlays decreased. Reducing the concentration of agar to 0.75% facilitated the formation of SP virus plaques, but better plaque production occurred under agarose overlays. The original parent virus consisted predominantly of virus particles that formed small plaques. The rate of neutralization of the parent virus by guinea pig antiserum prepared against the parent virus was faster than antiserum inactivation of a low-passage virus of the same serotype and strain. PMID- 4334293 TI - Early myocardial lesions in encephalomyocarditis (EMC) virus infected mice. PMID- 4334294 TI - Relationships between primary structures, conformations and biological activities of polypeptide hormones. PMID- 4334295 TI - [Functional reorganization of the activity of human brain neuron populations during short-term verbal memory]. PMID- 4334296 TI - [Electronic correction of the dynamic properties of a paramagnetic oxygen analyzer]. PMID- 4334297 TI - [Chromosomal abnormalities in a case of infiltrative ductal carcinoma of the breast]. PMID- 4334298 TI - Differential susceptibility to herpes simplex viruses of hamster cell lines established after exposure to chemically inactivated herpesvirus. PMID- 4334299 TI - Localization of complement-fixing antigens in cells: Epstein-Barr virus-induced membrane and interior cell antigens. PMID- 4334300 TI - [Functions of vesicular stomatitis virus modified by a temperature-sensitive mutation: demonstration of the structural protein affected by the matation ts 23]. PMID- 4334301 TI - A dominant epistatic gene which inhibits cellular susceptibility to RSV(RAV-O). PMID- 4334302 TI - Studies on arginyl transfer ribonucleic acid in herpes virus infected baby hamster kidney cells. PMID- 4334303 TI - A search for recombination between temperature-sensitive mutants of vesicular stomatitis virus. PMID- 4334305 TI - Role of vitamins in taurine synthesis from sulfate by the chick. PMID- 4334304 TI - Kinetics of interferon production in human leukocyte suspensions. PMID- 4334307 TI - Effect of protein intake on amino acid transport and adenosine 3',5' monophosphate content in rat liver. PMID- 4334306 TI - Rat liver histidase: glucose repression and half-life after casein hydrolysate feeding. PMID- 4334308 TI - The chemotherapy of gestational trophoblastic disease: principles of clinical management. PMID- 4334309 TI - Effects of vasopressin, water load and aminophylline on adenosine 3', 5' phosphate in human urine. PMID- 4334312 TI - Improving outcome. PMID- 4334310 TI - Effect of aminoglutethimide on urinary steroid excretion in patients with congenital adrenal hyperplasia due to incomplete 21-hydroxylase deficiency. PMID- 4334311 TI - The short-term effect of cortisone acetate upon fasting triglyceride and cholesterol in normal subjects and offspring of diabetic couples. PMID- 4334313 TI - Detection of fructose-1,6-diphosphatase deficiency with use of white blood cells. PMID- 4334314 TI - Change in lipoprotein composition with dietary carbohydrate. PMID- 4334315 TI - Effect of dietary fat and ethanol on lipemia. PMID- 4334316 TI - [Presence of DNA in oncogenic riboviruses]. PMID- 4334318 TI - Electroclinical and polygrophic investigations of sleep in nocturnal epilepsy. PMID- 4334317 TI - Isolation of parenchymal cells from normal, fatty and fibrotic livers. PMID- 4334319 TI - Rehabilitation of the mentally handicapped in Turkey: past and present. PMID- 4334321 TI - [Precise definition of some cytomorphological data on cancer of the stomach based on data derived from excised tumor imprints]. PMID- 4334320 TI - [Mechanism of the change in the level of enzyme activity of the blood serum in various diseases]. PMID- 4334322 TI - [Intermittent claudication in cauda equina radiculopathy]. PMID- 4334324 TI - Experiments on active immunization of pigs against foot-and-mouth disease. PMID- 4334323 TI - The brain specific proteins S 100 and 14.3.2 in experimental brain tumors of the rat. PMID- 4334327 TI - Microbial transformations of antibiotics. PMID- 4334325 TI - Experiments on the mode of spreading of Marek's disease virus. PMID- 4334326 TI - Studies on fowl cholera. I. Biochemical investigations of Pasteurella multocida. PMID- 4334328 TI - Comparative cytological studies of the carotid body. 2. Ultrastructure of the synapses on the chief cell. PMID- 4334329 TI - Chlorpromazine: inhibition of ACTH and cyclic 3',5'-AMP stimulated corticosterone synthesis. PMID- 4334330 TI - Adenyl cyclase in hepatic parenchymal and reticuloendothelial cells. PMID- 4334331 TI - Absence of hexokinase activity in plasma membranes of Morris hepatoma 5123 t.c. PMID- 4334332 TI - Prostaglandin antagonists: studies on the mode of action of polyphloretin phosphate. PMID- 4334333 TI - A ribonuclease substrate resistant to phosphodiesterase II: 5'-O-benzyluridine-3' (alpha-naphthylphosphate). PMID- 4334334 TI - Increased membrane ATPase and K + transport rates in Streptococcus faecalis induced by K + restriction during growth. PMID- 4334335 TI - Cyclic adenosine 3',5' monophosphate levels in rat myometrium under the influence of epinephrine, prostaglandins and oxytocin, correlations with uterus motility. PMID- 4334336 TI - EPR studies on the iron-sulfur centers of DPNH dehydrogenase during the redox cycle of the enzyme. PMID- 4334337 TI - 2-p-Toluidinylnaphthalene-6-sulfonate, a fluorescent reporter group for L isoleucyl-tRNA synthetase. PMID- 4334338 TI - Simplified method for isolation of intact avian and rat liver parenchymal cells. PMID- 4334339 TI - A new method for the sequence analysis of oligodeoxynucleotides. PMID- 4334340 TI - Studies of the mechanism of action of 3', 5'-cyclic nucleotides on hepatic glucose production. PMID- 4334341 TI - Collagen cross-linking: identification of two cyanogen bromide peptides containing sites of intermolecular cross-link formation in cartilage collagen. PMID- 4334342 TI - The thermostable allosteric nature of fructose 1,6-diphosphatase from an extreme thermophile. PMID- 4334343 TI - Inhibition by actinomycin D, cycloheximide and puromycin of steroid synthesis induced by cyclic AMP in interstitial cells. PMID- 4334345 TI - Isolation of plasma membranes from rat brain. PMID- 4334344 TI - Adenosine 2',5'-cyclic monosphate derivatives. II. Biological activity of some 8 substituted analogs. PMID- 4334346 TI - On the similarity of effects of aldosterone and adenosine 3',5'-phosphate on Na + transport and glucose metabolism in toad bladder. PMID- 4334347 TI - Net movements of monovalent and bivalent cations, and their relation to energy metabolism, in slices of hepatoma 3924A and of a mammary tumour. PMID- 4334348 TI - Oxidative phosphorylation in Azotobacter vinelandii. Effect of inhibitors and uncouplers on P-O ratio, trypsin-induced ATPase and ADP-stimulated respiration. PMID- 4334349 TI - Degradation and restoration of mitochondria upon deaeration and subsequent aeration of aerobically grown Saccharomyces cerevisiae cells. PMID- 4334350 TI - Measurement of steady-state values of respiration rate and oxidation levels of respiratory pigments at low oxygen tensions. A new technique. PMID- 4334351 TI - EPR studies at 20 degrees K on the mitochondrial respiratory chain. PMID- 4334352 TI - Effect of ATP on the EPR spectrum at 20 degrees K of phosphorylating sub mitochondrial particles. PMID- 4334353 TI - Identification of mutants defective in the first and second steps of de novo purine synthesis in Saccharomyces cerevisiae. PMID- 4334354 TI - Studies on the deoxyribonucleic acid from Spirillum. PMID- 4334355 TI - Synaptic control of electrotonic coupling between neurons. PMID- 4334356 TI - Hippocampal inputs to the lateral septal nucleus: patterns of facilitation and inhibition. PMID- 4334357 TI - [Experimental infection of mice with Herpes simplex virus]. PMID- 4334358 TI - [Effects of adrenalectomy on the monoaminergic structures of the median eminence of the rat]. PMID- 4334359 TI - [Hydrolysis of inorganic pyrophosphate by Mycobacteria]. PMID- 4334360 TI - Rapid gas chromatographic assays for androsterone and etiocholanolone in urine. PMID- 4334361 TI - [Antigoitrogenic properties of some anions in animals treated with propylthiouracil]. PMID- 4334362 TI - [Effect of antineoplastic agents on tumor cells in vivo and in vitro (literature review)]. PMID- 4334364 TI - Morphological and histochemical studies on autografts and homografts of the guinea-pig thyroid gland. IV. Oxidative enzymes. PMID- 4334363 TI - Histopathological and histochemical investigations on Trichinella spiralis infected mice after RES stimulation. PMID- 4334365 TI - [Nucleotide derivatives of biological importance. 8. Synthesis of adenosine triphosphate (ATP) analogs]. PMID- 4334366 TI - Collaboration between public and private agencies in developing a community mental health service. PMID- 4334367 TI - The impact of unitization on long-term patients. PMID- 4334368 TI - The roles of calcium and cyclic AMP in the stimulatory action of parathyroid hormone on thymic lymphocyte proliferation. PMID- 4334369 TI - Effects of caffeine on the intracellular distribution of calcium in frog sartorius muscle. PMID- 4334370 TI - Enzyme kinetics in mammalian cells. 3. Regulation of activities of galactokinase, galactose-1-phosphate uridyl transferase and uridine diphosphogalactose-4 epimerase in human erythrocytes. PMID- 4334371 TI - Chromatographic separation of ovarian dermoid cyst lipids and prostaglandins. PMID- 4334372 TI - Thin-layer chromatography of bacterial lipids on sodium acetate-impregnated silica gel. PMID- 4334373 TI - Responsiveness of the x-irradiated adrenal cortex to adreno-corticotrophin in dogs. PMID- 4334374 TI - Studies on an isolated adrenal cell suspension: adenosine 3',5'-cyclic monophosphate production and effects of adrenocorticotrophin and adenosine 3',5' cyclic monophosphate. PMID- 4334375 TI - The effect of diazepam on pituitary function in man. PMID- 4334376 TI - Determination of deoxycorticosterone in plasma by radioimmunoassay. PMID- 4334377 TI - Suppression of pituitary adrenocorticotrophic activity by tetracosactrin. PMID- 4334378 TI - Adrenal response to tetracosactrin in newborn infants. PMID- 4334379 TI - Central control of auditory input in the goldfish. I. Effect of shocks to the midbrain. PMID- 4334380 TI - Evaluation of an interferon inducer in viral respiratory disease. PMID- 4334381 TI - [Renin activity, angiotensinogen levels and plasma angiotensinase activity in patients with hypertensive diseases of the kidneys]. PMID- 4334382 TI - [Melena revealing primary liver cancer]. PMID- 4334383 TI - Group-specific antigens of ascites rat tumours induced by B77 virus. PMID- 4334384 TI - Host range differences among subgroup C members of avian tumour viruses. PMID- 4334385 TI - Comments on cryologic preservation of avian RNA oncogenic viruses. PMID- 4334386 TI - Effect of podophyllic acid ethylhydrazide on virus-induced sarcomas in chicks. PMID- 4334387 TI - The effect of some chemical agents and physical factors on the leukaemogenic activity of the murine leukaemia virus. PMID- 4334388 TI - [Cyclic AMP]. PMID- 4334389 TI - [Virus-like tubular formations detected in skin lesions in lupus erythematosus (electron microscope examinations)]. PMID- 4334390 TI - The relationship between the nuclear volumes and the DNA contents of the hepatocyte nuclei in the livers bearers of hepatocarcinomas, and of the hepatocarcinoma cells. PMID- 4334391 TI - [Morphological and biological differences between 2 sublines of the same transplanted hepatoma]. PMID- 4334392 TI - [Attempt at studying calcium-phosphorus metabolism in vitamin-D-resistant rickets (phosphatic diabetes)]. PMID- 4334393 TI - [Clinical and radiographic methods in the diagnosis of breast neoplasms]. PMID- 4334394 TI - [Practical significance of cytological examination of sputum in the diagnosis of lung cancer]. PMID- 4334395 TI - The effect of a paramagnetic center of 2.03 average g-value on d-glyceraldehyde-3 phosphate dehydrogenase. PMID- 4334396 TI - The influence of effectors modifying phosphorylase-a in the phosphorylase phosphatase reaction. PMID- 4334397 TI - Biochemical and morphological events associated with the development of fetal rat pancreas "in vivo" and "in vitro": effect of glucagon and of other agents. PMID- 4334398 TI - [The regulation of lipolysis in human adipose tissue, with special reference to the action of glucagon]. PMID- 4334399 TI - Serologic diagnosis of amebiasis. PMID- 4334400 TI - Schistosomiasis mansoni of the spinal cord. Report of a case. PMID- 4334401 TI - Virus-like particles in a case of vasculitis with brain tumor. PMID- 4334402 TI - Angiotensin-converting enzyme inhibitors from the venom of Bothrops jararaca. Isolation, elucidation of structure, and synthesis. PMID- 4334403 TI - Gas chromatographic determination of gangliosides in mouse cell lines and in virally transformed derivative lines. PMID- 4334404 TI - Some stereochemical requirements of Escherichia coli ribonucleic acid polymerase. Interaction with conformationally restricted ribonucleoside 5'-triphosphates: 8 bromoguanosine, 8-ketoguanosine, and 6-methylcytidine triphosphates. PMID- 4334405 TI - Cyclic 3',5'-nucleotide phosphodiesterase properties of the enzyme of human blood platelets. PMID- 4334406 TI - Adenyl cyclase and "ATPase" in rat corpus luteum. I. Some properties of the enzymes. PMID- 4334407 TI - Peptide inhibitors of pulmonary angiotensin I converting enzyme. PMID- 4334408 TI - International collaborative studies on the pertussis vaccine potency assay. Part played by the challenge in the mouse-protection test. AB - Because of wide variations in the methods used to assay the potency of pertussis vaccine, the effect of the type of challenge used in the mouse-protection test was studied. Eight laboratories took part in a collaborative investigation and the potencies of 4 pairs of vaccines were estimated. Two methods were used, a "local method" using local strains and procedures for challenge, and a "study method" using a distributed strain and a specified procedure. For both methods the challenge level (mouse LD(50)) and the number of colony-forming units per challenge dose varied greatly between laboratories.The results of the collaborative assay show that the use of a common challenge, Bordetella pertussis strain 18-323, and a uniform method for preparing the challenge did not reduce the heterogeneity of the results. Other factors influencing the results of potency assays, such as the use of different strains of mice and the effect of levels of challenge, have still to be investigated. PMID- 4334409 TI - The effect of cyclic adenosine 3',5'-phosphate on tumor immunity. PMID- 4334410 TI - In vitro demonstration of cell-mediated immunity to human brain tumors. PMID- 4334411 TI - New species of rapidly hybridizing RNA in contact-inhibited as well as transformed hamster cell lines. PMID- 4334413 TI - Effects of cytosine arabinoside and 1,3-bis(2-chloroethyl)-1-nitrosourea on human glial tumor cells. PMID- 4334412 TI - Isolation and chemical characterization of cell surface sialoglycopeptide fractions during progression of rat ascites hepatoma AS-30D. PMID- 4334414 TI - Renovascular hypertension in rats immunized with angiotensin II. PMID- 4334415 TI - Inotropic agents in hypoxic cat myocardium: depression and potentiation. PMID- 4334416 TI - Protocollagen proline hydroxylase activity in rat heart during experimental cardiac hypertrophy. PMID- 4334417 TI - [Correlation between deep brain structure biopotentials during the development of sleep in man]. PMID- 4334418 TI - Abnormalities of the hand associated with generalised developmental disorders of the skeleton. PMID- 4334419 TI - Operative treatment of congenital malformations of the hand. PMID- 4334420 TI - An anomalous accessory palmaris longus muscle. PMID- 4334421 TI - In vitro maturation and ovulation of oocytes of the catfish, Heteropneustes fossilis (Bloch): effects of mammalian hypophyseal hormones, catfish pituitary homogenate, steroid precursors and metabolites, and gonadal and adrenocortical steroids. PMID- 4334422 TI - L(+)-lactate dehydrogenase in sputum from patients with chronic obstructive lung diseases. PMID- 4334423 TI - Endemic nephritis and urinary tract cancer in Yugoslavia, Bulgaria and Rumania. PMID- 4334424 TI - Paget's disease of the scrotum: a case report with local lymph node invasion. PMID- 4334425 TI - [Chemodectomas of the retroperitoneal space and the stomach]. PMID- 4334426 TI - A case of monster twinning (thoracopagus) in the Sprague Dawley rat (Spartan strain). PMID- 4334427 TI - Preliminary report on the isolation and characterization of a virus from the respiratory tract of rabbits. PMID- 4334428 TI - Psorergatic mites in patas monkeys. PMID- 4334429 TI - Intensive repeated plasmapheresis for maximum yields of antibodies from a sheep immunized with a valuable antigen. PMID- 4334430 TI - Cutaneous horn in a rhesus monkey. PMID- 4334431 TI - Sustained pressure perfusion method. PMID- 4334432 TI - Blood chemistry of the sloth (Choloepus hoffmanni and Bradypus tridactylus). PMID- 4334433 TI - Persistent pupillary membrane: developmental review and an occurrence in Macaca mulatta. PMID- 4334434 TI - Diet-induced atherosclerosis and myocardial infarction in Japanese quail. PMID- 4334435 TI - Establishment of conditions for colony-breeding of the sand-rat Psammomys obesus. PMID- 4334436 TI - Formulation of a laboratory rabbit diet. PMID- 4334437 TI - A disease related to cage population density: tail lesions of C3H-HeJ mice. PMID- 4334438 TI - Virtual absence of infection with Herpesvirus simiae in colony-reared rhesus monkeys (Macaca mulatta), with a literature review on antibody prevalence in natural and laboratory rhesus populations. PMID- 4334439 TI - Effect of training upon pulmonary and systemic hemodynamics in beagle dogs. PMID- 4334440 TI - Venereal spirochetosis of rabbits (rabbit syphilis) due to Treponema cuniculi: a clinical, serological, and histopathological study. PMID- 4334441 TI - A heat-trap shelter for rhesus monkeys (Macaca mulatta) housed outdoors. PMID- 4334442 TI - A technic for multiple bleedings or intravenous inoculations of mink at prescribed intervals. PMID- 4334444 TI - Quantitative coagulation studies in mice. PMID- 4334443 TI - An all plastic system for housing small animals in trace element studies. PMID- 4334445 TI - Interactions of catecholamines with adenosine triphosphate in solutions and adrenal medullary granules. PMID- 4334446 TI - [Effect of ACTH, metopirone and dexamethasone on urinary excretion of 3-methoxy-4 hydroxymandelic acid (VMA) in patients following cerebral stroke]. PMID- 4334447 TI - [Behavior of enzymes connected with citric acid metabolism in various muscular diseases]. PMID- 4334448 TI - Hexamethylmelamine in inoperable bronchogenic carcinoma. PMID- 4334449 TI - Erythropoietin levels in patients with Wilms' tumor. Follow-up evaluation. PMID- 4334450 TI - [The antiviral activity of new chemotherapeutic drugs]. PMID- 4334451 TI - [The SV40 virus genome in transformed mammalian cells]. PMID- 4334452 TI - [Diagnosis and treatment of Kylin's syndrome (late pubertal cachexia)]. PMID- 4334453 TI - [Effect of ACTH on the content of cholesterol and its esters in the adrenal glands of rats and rabbits]. PMID- 4334454 TI - Angiotensin I: metabolism by plasma membrane of lung. AB - (8-L-[(14)C] phenylalanine) angiotensin I is metabolized in one passage through blood-free lungs. Approximately 20 percent of the radioactivity emerges as angiotensin 11, the remainder as lower homologs. Radioactivity is not retained by the lungs but has the same volume of distribution and mean transit time as blue dextran, a compound unlikely to leave the intravascular space. Plasma membrane fractions of lung are capable of converting angiotensin I to angiotensin II. These data, taken together, indicate the circulating angiotensin I is metabolized by enzymes of the luminal surface of pulmonary endothelial cells. PMID- 4334456 TI - [Gastric rupture. Wall fragility during gastroscopy]. PMID- 4334455 TI - [Adult X histiocytosis with pulmonary, thyroid, meningoencephalic and thalamo hypophyseal localizations]. PMID- 4334457 TI - [Left atrial thrombosis in mitral valve disease. Clinical and radiological signs noted in 292 cases]. PMID- 4334458 TI - [Osteo-onychodysplasia with nephropathy. Anatomo-clinical study]. PMID- 4334459 TI - [Disappearance of an intraventricular conduction disorder under diphenylhydantoin]. PMID- 4334460 TI - [Gonadal dysgenesis with ring-shaped chromosome in an adolescent girl]. PMID- 4334461 TI - [Turner's syndrome with ring-shaped x chromosome]. PMID- 4334462 TI - [Anatomo-pathological aspects of acute and chronic Budd-Chiari syndromes, apropos of 5 cases]. PMID- 4334463 TI - [Recurrent pericardial effusion in infants caused by benign hemangioendothelioma of the pericardium]. PMID- 4334464 TI - [Peculiarities of traditional African medicines]. PMID- 4334465 TI - [How Napoleon died]. PMID- 4334466 TI - [Synthetic corticotropin employed for a brief intravenous corticotropin tolerance test]. PMID- 4334467 TI - Malignant cell transformation by the SV-40 DNA and phagocytic activity related to alteration of cell membranes. PMID- 4334468 TI - Studies on tritiated thymidine incorporation into DNA molecules by electron microscopic autoradiography. PMID- 4334469 TI - Effect of complete adjuvant on vaccination of live attenuated Japanese encephalitis vaccine to swine for preventing viremia. 39. Epidemiological studies of J.E. PMID- 4334470 TI - Lumbar myelography with Conray Meglumin 282. Report of 100 investigations with special reference to the adverse effects. PMID- 4334471 TI - [Morphological studies on the effect of adrenocorticotropin (ACTH) administration of the neuromuscular junction]. PMID- 4334472 TI - [Endocrinological aspects of myasthenia gravis]. PMID- 4334473 TI - [Discussion on "endocrinological aspects of myasthenia gravis"]. PMID- 4334474 TI - [Clinical study in myasthenia gravis--clinical analysis and follow-up of 113 cases]. PMID- 4334475 TI - [Problems of antibiotic administration in myasthenia gravis]. PMID- 4334476 TI - [Some observations on the neuromuscular junction]. PMID- 4334477 TI - [Effects of long-term culturing and carcinogenic agents on transformation of glioma cells]. PMID- 4334478 TI - [Cytological study of the cell line derived from malignant human glioblastoma multiforme]. PMID- 4334480 TI - [Interaction of varicella-zoster virus and GMK cells and its use in laboratory diagnosis]. PMID- 4334479 TI - On the epidemiology of tuberculosis in some selected countries. Highlights and prospects for control and eradication. II. PMID- 4334481 TI - [The effects of alcohol on the nervous system]. PMID- 4334482 TI - [Adrenocortical component in the mechanism of action of some anti-inflammatory agents]. PMID- 4334483 TI - [Sensitivity of normal and polyoma-virus-transformed mouse and hamster cells to the toxic action of antineoplastic agents in vitro]. PMID- 4334484 TI - [Desensitization and mechanisms of its development (literature review)]. PMID- 4334487 TI - Effect of phenylisopropyladenosine ((Th 162) on lipolysis in human adipose tissue slices. PMID- 4334485 TI - [Activation of the body fibrinolytic system by pharmacologic agents of non enzymatic nature (literature review)]. PMID- 4334488 TI - Jendrassik maneuver facilitation and fractionated patellar reflex times. PMID- 4334486 TI - Effects of Ca ++ on lipolysis in human omental adipose tissue in vitro. PMID- 4334489 TI - Structure-function studies on glyceraldehyde 3-phosphate dehydrogenase. IV. Subunit interactions of the rabbit muscle and yeast enzymes. PMID- 4334490 TI - The proton transfer reactions of muscle pyruvate kinase. PMID- 4334491 TI - Radioimmunoassay for cyclic nucleotides. I. Preparation of antibodies and iodinated cyclic nucleotides. PMID- 4334492 TI - Radioimmunoassay for cyclic nucleotides. II. Adenosine 3',5'-monophosphate and guanosine 3',5'-monophosphate in mammalian tissues and body fluids. PMID- 4334493 TI - Radioimmunoassay for cyclic nucleotides. 3. Effect of ischemia, changes during development and regional distribution of adenosine 3',5'-monophosphate and guanosine 3',5'-monophosphate in mouse brain. PMID- 4334494 TI - Involvement of phospholipids in the D-glucose uptake activity of isolated human erythrocyte membranes. PMID- 4334495 TI - Glucagon receptors in -cells. Binding of 125 I-glucagon and activation of adenylate cyclase. PMID- 4334496 TI - Purification, modification during purification, and characterization of a deoxyribonuclease from Pseudomonas aeruginosa. PMID- 4334497 TI - Ion transport and respiratory control in vesicles formed from cytochrome oxidase and phospholipids. PMID- 4334498 TI - Enzymes catalysing ethanol metabolism in neural and somatic tissues of the rat. PMID- 4334499 TI - N-acetyl-L-aspartic acid content of human neural tumours and bovine peripheral nervous tissues. PMID- 4334501 TI - Metabolism of brain during sleep and wakefulness. PMID- 4334500 TI - Pyruvate metabolism in the lobster nerve as affected by the partial pressure of carbon dioxide: observations on the synthesis of acetylcholine and on metabolic compartmentation. PMID- 4334502 TI - Role of mediated transport in the electrically-induced release of ( 14 C) glycine from slices of rat spinal cord. PMID- 4334503 TI - 2',3'-Cyclic nucleotide 3'-phosphohydrolase activity of the central nervous tissue in experimental allergic encephalomyelitis. PMID- 4334504 TI - The occurrence of IgM and complement factors along myelin sheaths of peripheral nerves. An immunohistochemical study of the Guillain-Barre syndrome. Preliminary communication. PMID- 4334505 TI - Polar lipids of water-melon (Citrullus vulgaris) and squash-melon (Citrullus vulgaris variety fistulosus) seeds. PMID- 4334506 TI - Characteristics of a virus found in a Rous mouse cell line, SR-C3H-2127. PMID- 4334507 TI - Ultrastructural observation of intranuclear inclusion bodies in human myeloma cells. PMID- 4334508 TI - Calcium release induced by interaction of angiotensin with its receptors in smooth muscle cell microsomes. PMID- 4334509 TI - [Malignant form of pulmonary chemodectoma]. PMID- 4334510 TI - Comparative effects of 25-hydroxycholecalciferol and vitamin D 3 in thyro parathyroidectomized rats. PMID- 4334511 TI - Effects of alcohol on hepatic metabolism. PMID- 4334512 TI - Hereditary erythrocyte glutathione reductase deficiency. PMID- 4334513 TI - [Suicide attempts: psychiatric approach in a general hospital]. PMID- 4334514 TI - [Tissue and cell culture in biology and medicine]. PMID- 4334515 TI - [Possible role of viruses in the development of acute and chronic lung diseases in adults and children in Magadan]. PMID- 4334516 TI - [Ultrastructural characteristics of the anterior pituitary lobe of newborn rats]. PMID- 4334517 TI - [Change in the reactive inhibition of mitosis in pathological conditions (experimental study)]. PMID- 4334518 TI - [Electron microscopic study of biopsied sections of small intestine mucosa in patients with cholera and characteristics of the ultrastructure of causative agents of cholera in relation to toxinogenesis]. PMID- 4334519 TI - [Malignant mucocele of the appendix]. PMID- 4334520 TI - Non enzymic formation of nerolidol from farnesyl pyrophosphate in the presence of bivalent cations. PMID- 4334521 TI - Ribosomal factors effecting the stimulation of cell-free protein synthesis in the prescence of foot-and-mouth disease virus ribonucleic acid. PMID- 4334522 TI - Phase transitions in sphingomyelin thin filsm. A spin label study. PMID- 4334523 TI - Adenosine triphosphate and catabolite repression of -galactosidase in escherichia coli. PMID- 4334524 TI - Formation of polyprenyl phosphates by a cell-free enzyme of Micrococcus lysodeikticus. PMID- 4334525 TI - Polyphosphoinositides in normal and neoplastic rodent astrocytes. PMID- 4334526 TI - Protein kinase mediated phosphorylation of the rat liver plasma membrane. PMID- 4334527 TI - A new enzyme that specifically inactivates apo-protein of NAD-dependent dehydrogenases. PMID- 4334528 TI - P-nitrophenyl phosphate as substrate for rabbit liver fructose diphosphatase. PMID- 4334529 TI - -Glycerolphosphate dehydrogenase: a regulatory enzyme. PMID- 4334530 TI - Solubility of toluene in bovine liver glutamate dehydrogenase solutions and enhancement of enzyme association. PMID- 4334531 TI - Kinetic characteristics of phosphofructokinase from Lactobacillus casei var. Rhamnosus ATCC 7469 and Lactobacillus plantarum ATCC 14917. PMID- 4334532 TI - Effect of EDTA on Escherichia coli alkaline phosphatase. PMID- 4334533 TI - The study of the actin pattern of an exo- -(1--3)-D-glucanase. PMID- 4334534 TI - An endopeptidase from rheumatoid synovial tissue culture. PMID- 4334535 TI - [Effect of acquisition level on the increase of paradoxical sleep duration due to an avoidance conditioning in the rat]. PMID- 4334536 TI - [Endonucleasic activity of purified preparations of Polyoma virus]. PMID- 4334537 TI - [Sensitivity of cells in a state of antiviral resistance to interferon]. PMID- 4334538 TI - [Induction of antinuclear antibodies in mice by the Graffi's leukemogenic virus]. PMID- 4334539 TI - [Isolation of a mutant of Rous virus dependant on cellular density]. PMID- 4334541 TI - [Hidradenoma papilliferum vulvae]. PMID- 4334540 TI - Structural and metabolic interrelationships among glycerophosphatides of rat liver in vivo. PMID- 4334542 TI - [Acute necrotic encephalitis due to Herpes simplex virus]. PMID- 4334543 TI - Phenobarbital and neonatal jaundice. The need for more knowledge. PMID- 4334544 TI - Renal cysts in childhood. A descriptive classification with clinical notes. PMID- 4334545 TI - Primary linitis plastica of the rectum: report of two cases. PMID- 4334546 TI - Some observations on complement-fixing antibodies to the EB virus. AB - Complement-fixing antibodies against an antigen prepared from the EB3 line of cultured Burkitt tumour cells were studied in various groups of patients and control individuals. Higher antibody titres were observed in patients with Burkitt's tumour than in African patients with other diagnoses. Significantly more medical students and nurses with a history of infectious mononucleosis possessed antibodies than those with no such history. Low levels of antibody were observed in patients during the acute phase of infectious mononucleosis and these levels were significantly lower than those in patients admitted to the same hospital with other diagnoses. During the early months following the acute phase of illness, EB complement-fixing antibodies remained stationary or apparently declined in titre but, in patients tested one or more years later, significantly higher antibody levels were observed. PMID- 4334547 TI - Serum protein electrophoresis among workers in an Egyptian cement-asbestos pipe factory. PMID- 4334548 TI - Further characterization of the local respiratory tract antibody response induced by intranasal instillation of inactivated rhinovirus 13 vaccine. PMID- 4334549 TI - Interaction of tyramine and guanethidine in the spleen of the cat. PMID- 4334550 TI - Interferon-inducing activity of acidic polysaccharides. I. Induction of rabbit serum interferon by Hansenula phosphomannans. PMID- 4334551 TI - Intestinal resistance in the experimental enteric infection of mice with a mouse adenovirus. II. Determination of the neutralizing substance in the intestinal tract as an IgA antibody. PMID- 4334553 TI - [Survival of non-poliomyelitic enteroviruses in a frozen state]. PMID- 4334552 TI - [Effect of antipyretic drugs on Herpes simplex virus infection in tissue culture]. PMID- 4334554 TI - Autoradiographic and fluorescence antibody studies of the human host immune response to gliomas. PMID- 4334555 TI - [Construction of pedigrees of cultured hepatoma cells, Culb TC of the rat and the analyses of the effects of gamma rays]. PMID- 4334556 TI - [The synovial membrane and synovial fluid in the normal and pathological state. 1. Structure and ultrastructure of the synovial membrane]. PMID- 4334557 TI - [Digital herpes]. PMID- 4334558 TI - [Away with quacks. Law no. 72-7 of 3 January 1972]. PMID- 4334559 TI - The fetal aspects of Tay-Sachs disease. PMID- 4334560 TI - Respiratory disease in group day care. PMID- 4334561 TI - [Clinical aspects and radiotherapy of cylindroma]. PMID- 4334562 TI - [Bone changes in prenatal infections]. PMID- 4334563 TI - [Effects of a combination of borate and magnesium fluorsilicate on experimental caries in the rat]. PMID- 4334564 TI - Kwashiorkor: a prospective ten-year follow-up study. PMID- 4334565 TI - Circadian rhythmicity of gastric secretion and cyclic 3', 5'-adenosine monophosphate contents of gastric mucosa in rats. PMID- 4334566 TI - [Insulin and glucagon. Recent discoveries, problems and questions concerning their biosynthesis, secretion and mode of action]. PMID- 4334567 TI - Some aspects of androgen secretion by the canine adrenal. PMID- 4334568 TI - Alkaline phosphatase isozyme in rats with damage in hepatobiliary tract. PMID- 4334569 TI - Responses of plasma LH to insulin-induced hypoglycemia, basopressin, premarin and clomiphene. PMID- 4334570 TI - Purification and properties of N-acetylglucosamine kinase from rat liver. PMID- 4334571 TI - [The serological investigations of ARD infections in Turkey during the 1968-69 and 1969-70 seasons]. PMID- 4334572 TI - [New antigens arising in virus-infected cells]. PMID- 4334573 TI - [The relationship between the antiviral and enzymatic activity of deoxyribonuclease]. PMID- 4334574 TI - [Reactogenic and immunogenic properties of an attenuated strain of chicken pox virus]. PMID- 4334575 TI - [The relationship between inter- and postreproductive spread of adenovirus infection in human amnion cells]. PMID- 4334576 TI - [Various forms of respiratory viral diseases among children in Leningrad]. PMID- 4334577 TI - [The effect of pancreatin on rhinovirus multiplication and plaque formation]. PMID- 4334578 TI - Vaccination with complete adjuvant-added inactivated virus vaccine of Japanese encephalitis to swine for preventing viremia (with specific reference to the effect of vaccination on viremia; epidemiological study on Japanese encephalitis. 35). PMID- 4334579 TI - Transformation of antibody of Japanese encephalitis from IGM to IGG in experimental infected hen and transmission of IGG from hen to chicks. (epidemiological study on Japanese encephalitis. 37). PMID- 4334580 TI - The fine structure of the endocrine pancreatic cells of Ichthyophis kohtaoensis (Gymnophiona, amphibia). PMID- 4334581 TI - Isolation and characterization of -1,4-N-acetylmuramyl-N-acetylglucosamine and its O-acetyl derivative. PMID- 4334582 TI - Periodate oxidations of enamines. I. Oxidation of adenosine 5'-monophosphate in the presence of methylamine. PMID- 4334583 TI - Isolation of glycopeptides from low- and high-density platelet plasma membranes. PMID- 4334584 TI - Minor species of ribonucleic acid associated with rat liver mitochondria. PMID- 4334585 TI - Phenylalanyl transfer ribonucleic acid synthetase from Escherichia coli. Reaction parameters and order of substrate addition. PMID- 4334587 TI - Phenylalanyl transfer ribonucleic acid synthetase from Escherichia coli. Analysis of the adenosine triphosphate binding site. PMID- 4334586 TI - Phenylalanyl transfer ribonucleic acid synthetase from Escherichia coli. Analysis of the phenylalanine binding site. PMID- 4334588 TI - [Connective tissue tumors of the soft parts (apropos of 30 cases)]. PMID- 4334589 TI - [Differentiation of chondrogenic anlagen of chick embryos cultured in vitro on various media]. PMID- 4334590 TI - [Agglutination by concanavalin A of chick embryo fibroblasts transformed by the Rous sarcoma virus (SR-RSV) and a thermosensitive mutant of this virus]. PMID- 4334591 TI - The effect of respiratory deficiency on the alcohol dehydrogenase activity of baker's yeast. PMID- 4334592 TI - Alcohol dehydrogenase activity in the yeast Saccharomyces fragilis. PMID- 4334593 TI - [Our experience with the therapy of tumors of the central nervous system in 130 children]. PMID- 4334594 TI - Natural infection with infectious bovine rhinotracheitis virus in goats. PMID- 4334595 TI - Presleep experience and home dream reporting: an exploratory study. PMID- 4334596 TI - Study on rubber base impression materials. XXVI. Discussions on the setting mechanism of polysulfide rubber as the dental impression materials, chiefly viewed from the variations of viscosity and molecular weight. 6. Curing by potassium permanganate. PMID- 4334597 TI - The effects of germine-3-acetate on neuromuscular transmission. PMID- 4334598 TI - Effects of d-tubocurarine on the frog sympathetic ganglion cell and on synaptic function. PMID- 4334599 TI - The Furth-Columbia rat Wilms tumor. PMID- 4334600 TI - Studies on radioimmunoassay for arginine vasopressin. PMID- 4334601 TI - Effect of vasopressin, cyclic 3',5'-AMP, and chlorpropamide on water permeability of toad urinary bladder. PMID- 4334602 TI - Role of vasopressin in the regulation of ACTH secretion: studies with intrapituitary injection technique. PMID- 4334603 TI - On the corticotropin releasing activity of antidiuretic hormone. PMID- 4334604 TI - Adenylic acid-rich sequence in RNAs of Rous sarcoma virus and Rauscher mouse leukaemia virus. PMID- 4334605 TI - [A field trial on the effect of vitamin D 3 against parturient paresis]. PMID- 4334606 TI - [The present state concerning food-borne diseases]. PMID- 4334607 TI - [The treatment of insulinoma with streptozotocin]. PMID- 4334608 TI - Ultrastructural changes in hypokalemic periodic paralysis. PMID- 4334609 TI - [Malignant melanoma: histological findings and their significance for prognosis]. PMID- 4334610 TI - [A case of cylindroma of the trachea]. PMID- 4334611 TI - [The renin-angiotensin system in patients with cirrhosis of the liver]. PMID- 4334612 TI - Paralytic poliomyelitis in children with or without immunization against poliomyelitis. PMID- 4334613 TI - Relationship between high density lipoprotein and alkaline phosphatase in the sera from patients with liver metastasis of cancer. PMID- 4334614 TI - Studies of cytomegalovirus infection in newborn infants. PMID- 4334615 TI - Studies on early biochemical changes in female rat liver after administration of ethionine. PMID- 4334616 TI - [The electromyogram as an aid in determining the necessity for therapeutic orthopedic surgery]. PMID- 4334617 TI - [Tetrameric poly-syndactylia combined with marked brachydactylia]. PMID- 4334618 TI - Studies on the cytophysiology of the fat body of the American silkmoth. PMID- 4334619 TI - Fine structure of the lateral-line organ of the common eel, Anguilla japonica. PMID- 4334620 TI - Fine structure of the mouse anterior pituitary maintained in a short-term incubation system. PMID- 4334621 TI - The morphological relationship between mitochondria and cytoplasmic membranes of the follicular oocyte in domestic pig. PMID- 4334623 TI - Infections in 18,000 infants and children in a controlled study of respiratory tract disease. II. Variation in adenovirus infections by year and season. PMID- 4334622 TI - Evidence for an SV40-related papovavirus infection of man. PMID- 4334624 TI - N-Methylation of dopamine to epinine in adrenal medulla: a new model for the biosynthesis of adrenaline. PMID- 4334629 TI - [Further studies on the influence of prostaglandin E 1 on the neuromuscular transmission in mammals]. PMID- 4334630 TI - [So-called "Parinaud's syndrome"]. PMID- 4334631 TI - [Effects of non-histonic nuclear proteins on embryonic cells of Amphibia cultured in vitro]. PMID- 4334632 TI - [Symposium on the current status of the study of protein hormones]. PMID- 4334633 TI - Histopathological analysis of kidney tumors in rats induced by chemical carcinogens. PMID- 4334634 TI - A new floating cell line derived from human pulmonary carcinoma of oat cell type. PMID- 4334635 TI - Antibody in sera of pulmonary cancer patients against specific surface antigen of oat cells. PMID- 4334636 TI - Spontaneous production of murine type C virus particles by mouse Rous sarcoma cells after long-term in vitro cultivation. PMID- 4334637 TI - Expression of the sarcoma genome in a Rous mouse tumor cell line, SR-C3H-2127. PMID- 4334638 TI - [Cardiovascular resonance in Paget's disease]. PMID- 4334639 TI - Rhamnolipids produced by Pseudomonas aeruginosa grown on n-paraffin (mixture of C 12 , C 13 and C 14 fractions). PMID- 4334640 TI - Complement as a mediator of the inflammatory response: interaction of complement with mammalian and bacterial enzymes. PMID- 4334641 TI - A review of the physiological and pharmacological effects of pyrophosphate and diphosphonates on bones and teeth. PMID- 4334642 TI - Human gingival collagenase: purification, molecular weight, and inhibitor studies. PMID- 4334643 TI - Extracellular space in the central nervous system of the leech, Mooreobdella fervida. PMID- 4334644 TI - Isolation and chemical nature of the receptor for d-tubocurarine in nerve-ending membranes of the cerebral cortex. PMID- 4334646 TI - Effects of micro-iontophoretic administration of magnesium and calcium on neurones in the central nervous system of cats. PMID- 4334645 TI - Nerve electrical activity; depression by puromycin not related to inhibited protein synthesis. PMID- 4334647 TI - L-glutamate blockade of transmission at the giant synapse of the squid stellate ganglion. PMID- 4334648 TI - Effectiveness of temporal pattern in the input to a ganglion: inhibition in the cardiac ganglion of spiny lobsters. PMID- 4334649 TI - Calcium accumulation by isolated nerve ending particles from brain. I. The site of energy-dependent accumulation. PMID- 4334651 TI - Influence of ionic environment on the relationship between pre- and postsynaptic potentials. PMID- 4334650 TI - Calcium accumulation by isolated nerve ending particles from brain. II. Factors influencing calcium movements. PMID- 4334652 TI - Neuromuscular transmission in cultures of adult human and rodent skeletal muscle after innervation in vitro by fetal rodent spinal cord. PMID- 4334653 TI - The case of the defrocked nurse. PMID- 4334654 TI - Micro-ecology: interactional dimensions of space. PMID- 4334655 TI - Need for self--esteem in the aged: a literature review. PMID- 4334656 TI - The myth of the unmotivated family. PMID- 4334658 TI - Feeding elderly patients. PMID- 4334657 TI - Another approach to contraception. PMID- 4334659 TI - Patient involvement in planning own care: staff and patient attitudes. PMID- 4334660 TI - Behavior modification: two nurses tell it like it is. PMID- 4334661 TI - [Dysontogenetic kidney tumors in early childhood]. PMID- 4334662 TI - [Cytomegalovirus infections in adults]. PMID- 4334663 TI - [Mixed tumors of the pharyngeal extension of the parotid gland]. PMID- 4334664 TI - [Brain tumors. Diagnostic record]. PMID- 4334665 TI - [Effects of amantadine on the electric activity of the brain during sleep in patients with Parkinsonism]. PMID- 4334666 TI - [Organization of nocturnal sleep in parkinsonian patients: modifications of the phases and cycles in the course of pharmacological treatment]. PMID- 4334667 TI - [Bronchiolo-alveolar carcinoma in the lung with scleroderma]. PMID- 4334668 TI - [Peripheral neuropathies as complications in anticoagulant therapy]. PMID- 4334669 TI - [Ontogenesis of foot-and-mouth disease virus (electron microscopic study)]. PMID- 4334670 TI - [Foot-and-mouth disease virus in the cells of a hog kidney subculture]. PMID- 4334671 TI - [Improving the typification of foot-and-mouth disease virus]. PMID- 4334673 TI - [Carbohydrate metabolism in cells infected with foot-and-mouth disease virus]. PMID- 4334672 TI - [Antigenic properties of some strains of foot-and-mouth disease virus]. PMID- 4334675 TI - Renal hypertension and angiotensin antibodies. PMID- 4334674 TI - Carbon disulfide poisoning: a review. PMID- 4334676 TI - The etiological problem of viral hepatitis. PMID- 4334677 TI - [Phosphorylation of aminoglycoside antibiotics by the EV strain of the Plague microbe carrying the episome of multiple drug resistance]. PMID- 4334678 TI - Hypsarrhythmia developing in hospital: recovery with early treatment. PMID- 4334679 TI - A case of hereditary methaemoglobinaemia. PMID- 4334680 TI - Erythrocyte membrane-bound enzymes: ATPase, phosphatase and adenylate kinase in human, bovine and porcine erythrocytes. PMID- 4334681 TI - Hindrance of solute diffusion within membranes as measured with microporous membranes of known pore geometry. PMID- 4334682 TI - Interaction of antibiotics with membranes: chlorothricin. PMID- 4334683 TI - Interaction of antibiotics with membranes: polymyxin B and gramicidin S. PMID- 4334684 TI - The isolation of the envelopes of rat liver nuclei. PMID- 4334685 TI - Thiamine triphosphatase in the nervous system. PMID- 4334686 TI - High resolution proton relaxation studies of lecithins. PMID- 4334687 TI - The lipids of the plasma membranes and endoplasmic reticulum from cultured baby hamster kidney cells (BHK21). PMID- 4334688 TI - Probenecid: effects on water permeability in frog urinary bladder. PMID- 4334689 TI - [Novikoff hepatoma transplantability in Sprague Dawley rats]. PMID- 4334690 TI - [Regulation of some processes of biochemical homeostasis in diabetic rats with normal or fasting diet]. PMID- 4334691 TI - [Quantitative data on nocturnal REM sleep in the normal subject in experimental sensory deprivation (ESD)]. PMID- 4334692 TI - A kinetic approach to cellular interaction in delayed-type hypersensitivity. PMID- 4334693 TI - Magnetic resonance studies on the components of human erythrocyte membranes. PMID- 4334694 TI - The humerus supracondylar process syndrome. PMID- 4334695 TI - Overgrowth of an extremity caused by glomus tumor. PMID- 4334696 TI - A sensitive gonadotropin responsive system: radioimmunoassay of testosterone production by the rat testis in vitro. PMID- 4334697 TI - Stimulation of DNA synthesis in isolated chondrocytes by sulfation factor. PMID- 4334698 TI - Rat and mouse brain corticosterone. PMID- 4334699 TI - Stimulation of growth release by microinjection of norepinephrine into hypothalamus of baboons. PMID- 4334700 TI - Effects of adrenocorticotrophic hormone, growth hormone, prolactin, adrenalectomy and corticoids upon the weight, protein and nucleic acid content of the female rat preputial glands. PMID- 4334701 TI - Steroid monosulphates in urine from male rat pseudohermaphrodites. PMID- 4334702 TI - Effect of glucocorticoids on bone resorption in tissue culture. PMID- 4334703 TI - Metabolic clearance and secretion rates of TSH following adrenalectomy and corticosterone administration in the rat. PMID- 4334704 TI - Inhibitory effect of excess iodide on thyroid hormone release as measured by intracellular colloid droplets. PMID- 4334705 TI - [Biology of herpesviruses]. PMID- 4334706 TI - [Infections due to herpes simplex virus, recurrent disease and problem of latency]. PMID- 4334708 TI - [Cytomegalic inclusion disease]. PMID- 4334707 TI - [Herpetic disease]. PMID- 4334710 TI - [Herpesvirus equinus infections]. PMID- 4334711 TI - [Relation between herpesvirus and tumors: model of Burkitt's lymphoma]. PMID- 4334709 TI - [Eye diseases due to herpesvirus. (Herpesvirus hominis, varicella-zoster virus)]. PMID- 4334712 TI - Isolation of nuclei from ascites hepatoma AH-130 cells of rats by a detergent. PMID- 4334713 TI - [In vitro studies on the biosynthesis of corticosteroids in the rat adrenal gland and on the effect of ACTH. II. Comparison of the synthesis from endogenous precursors with that from exogenous (4- 14 C)cholesterol, (4- 14 C)pregnenolone and (4- 14 C)progesterone]. PMID- 4334715 TI - [Chromophoric substrates. V. Determination of collagenase using N-((azulene-4 yl)acetyl)peptides]. PMID- 4334716 TI - [Chromophoric substrates. VI. The specificity of collagenase]. PMID- 4334714 TI - Inhibition of acylneuraminate pyruvate-lyase: evidence of intermediary Schiff's base formation and of a possible role of histidine residues. PMID- 4334717 TI - Chromatographic separation of gangliosides on precoated silicagel thin-layer plates. PMID- 4334718 TI - Effect of dibutyryl cyclic AMP (DBcAMP) and parathyroid hormone (PTH) on intestinal calcium absorption (in vivo studies with 47 Ca). PMID- 4334720 TI - Quantitative studies of phagocytosis by polymorphonuclear leukocytes: use of emulsions to measure the initial rate of phagocytosis. AB - Polymorphonuclear leukocytes suspended in Krebs-Ringer phosphate medium ingest paraffin oil containing Oil Red O emulsified with a variety of substances. Spectrophotometric determination of Oil Red O in the cells after uningested particles have been removed by differential centrifugation provides a quantitative measure of phagocytosis. This system has been used to investigate the effects of several drugs and hormones on the initial rate of phagocytosis and to approach the question of how the surface of a particle influences its acceptability as a substrate for phagocytosis. The rate of uptake of paraffin oil emulsified with bovine albumin was constant for 6 min and was proportional to cell concentration when saturating concentrations of paraffin oil emulsion were used. At lower concentrations of substrate, the initial rate of phagocytosis was directly proportional to paraffin oil concentration. The increment in glucose oxidation associated with phagocytosis varied directly with the initial rate of particle uptake. The rate of ingestion of the albumin emulsion was not altered by serum (2-20%, v/v), glucose (5-20 mM), or omission of potassium from the medium. The rate of phagocytosis was decreased 65% if magnesium was omitted, and was essentially zero in the absence of divalent cations. The initial rate of uptake was inhibited by inhibitors of glycolysis, by N-ethylmaleimide (0.05-1 mM), colchicine (0.001-0.1 mM), theophylline (1 and 2 mM), dibutyryl cyclic AMP (1 mM), hydrocortisone (2.1 mM), and ethanol (85 mM). Inhibitors of oxidative phosphorylation and dexamethasone (0.01 mM) were without effect, while insulin (2 mU/ml) slightly stimulated the phagocytic rate. Paraffin oil emulsified with different agents was used to approach the question of how the surface of a particle influences its acceptability as a substrate for phagocytosis. Emulsions prepared with nonionic detergents, methylated proteins, and proteins with a weak net charge at pH 7.4 were poorly ingested. On the other hand emulsions prepared with agents of strong net positive or negative charge were rapidly taken up. The effect of divalent cations on the rate of phagocytosis varied with the nature of the emulsifier, but was not related in any simple, direct fashion to the net surface charge of the particles. However, it has not been conclusively established that charge was the only variable of the emulsion particles employed. PMID- 4334722 TI - Studies on myoinositol. 8. The incorporation of 3 H-myoinositol into phosphatidyl-inositol of fatty liver. PMID- 4334721 TI - Behavior of acetyl groups combined with sulfhydryl groups in protein. II. Behavior of acetyl groups combined with sulfhydryl groups in yeast alcohol dehydrogenase. PMID- 4334719 TI - Metabolic regulation of heme catabolism and bilirubin production. I. Hormonal control of hepatic heme oxygenase activity. AB - Heme oxygenase (HO), the enzyme system catalyzing the conversion of heme to bilirubin, was studied in the liver and spleen of fed, fasted, and refed rats. Fasting up to 72 hr resulted in a threefold increase in hepatic HO activity, while starvation beyond this period led to a gradual decline in enzyme activity. Refeeding of rats fasted for 48 hr depressed hepatic HO activity to basal values within 24 hr. Splenic HO was unaffected by fasting and refeeding. Hypoglycemia induced by injections of insulin or mannose was a powerful stimulator of hepatic HO. Glucose given together with the insulin abolished the stimulatory effect of the latter. Parenteral treatment with glucagon led to a twofold, and with epinephrine to a fivefold, increase of hepatic HO activity; arginine, which releases endogenous glucagon, stimulated the enzyme fivefold. These stimulatory effects of glucagon and epinephrine could be duplicated by administration of cyclic adenosine monophosphate (AMP), while thyroxine and hydroxortisone were ineffective. Nicotinic acid, which inhibits lipolysis, failed to modify the stimulatory effect of epinephrine. None of these hormones altered HO activity in the spleen. These findings demonstrate that the enzymatic mechanism involved in the formation of bilirubin from heme in the liver is stimulated by fasting, hypoglycemia, epinephrine, glucagon, and cyclic AMP. They further suggest that the enzyme stimulation produced by fasting may be mediated by glucagon released in response to hypoglycemia. The possibility is considered that the enhanced HO activity in the liver may increase hepatic heme turnover and hence, bilirubin production, which may explain the rise of unconjugated serum bilirubin observed in fasting or hypoglycemic individuals. PMID- 4334723 TI - [Solitary giant-cell reticulo-histiocytoma]. PMID- 4334724 TI - [Glomus tumors and their treatment]. PMID- 4334725 TI - [Clinical aspects of synoviomas]. PMID- 4334726 TI - Biochemical approaches to prediction of response in solid tumors. PMID- 4334727 TI - [Cancer and opisthorchiasis of the liver]. PMID- 4334728 TI - [Evaluation of cardiac and blood circulatory pharmaceutical agents on the anesthetized experimental animal with simultaneous registration of ventricular and aortic root pressure]. PMID- 4334729 TI - [Acquired glandular toxoplasmosis, infectious mononucleosis, adenovirosis and rebeola from the viewpoint of differential diagnosis]. PMID- 4334730 TI - Sleep and disease. PMID- 4334731 TI - A study of degeneration and regeneration in the divided rat sciatic nerve based on electron microscopy. I. The traumatic degeneration of myelin in the proximal stump of the divided nerve. PMID- 4334732 TI - [Immunofluorescent localization in adenohypophyseal cells of corticotrophic and and -melanotrophic secretions in the cow, the sheep, and the pig]. PMID- 4334734 TI - Elementary granules, small vesicles and exocytosis in the rat neurohypophysis after acute haemorrhage. PMID- 4334733 TI - [Fine structure of the epithelia of the amnion, umbilical cord and skin in fetal sheep of different stages]. PMID- 4334735 TI - Brush-border formation in the midgut of an insect, Calliphora erythrocephala Meigen. The formation of microvilli in the midgut during embryonic development. PMID- 4334737 TI - [Studies on revaccination of pigs using an ethylethylene imine (EEI)-DEAE-dextran vaccine against foot-and-mouth disease (FMD) of the subtype O 1 ]. PMID- 4334736 TI - [Electron microscopic studies of epithelial structure of the gastrointestinal tract of Hirudo medicinalis L. I. Epithelium of the diverticulum]. PMID- 4334738 TI - [Occurrence of RSV-neutralizing antibodies in flowls and their importance in avian leucosis]. PMID- 4334739 TI - Lymphography in the treatment of carcinoma of the vulva. PMID- 4334741 TI - Plasma fibrinogen in health and disease. Its application in the differential diagnosis of an enlarged and irregular liver. PMID- 4334742 TI - Methods for determination of carbonyl compounds by 2,4-dinitrophenylhydrazine and their application to the assay of aldehyde dehydrogenase. PMID- 4334743 TI - A spectrophotometric assay for hypoxanthine-guanine phosphoribosyltransferase. PMID- 4334740 TI - Molecular aspects of the storage and uptake of catecholamines. PMID- 4334744 TI - Enzymic synthesis of saccharopine- 14 C. PMID- 4334745 TI - [Occurrence of marek virus (MV)-associated precipitating antibodies in chickens and their relation to Marek's disease]. PMID- 4334746 TI - Electron spin resonance of chromanoxy free radicals from alpha, zeta, beta, gamma, delta-tocopherol and tocol. PMID- 4334747 TI - Distribution of chylomicron cholesteryl ester between parenchymal and Kupffer cells of rat liver. PMID- 4334748 TI - The subcellular distribution of short-chain fatty acyl-CoA synthetase activity in rat tissues. PMID- 4334749 TI - Intracellular localization of fatty acid synthesis in chick-embryo liver and stimulation of synthesis by exogenous glucose. PMID- 4334750 TI - Regional distribution of polyphosphoinositides in rat brain. PMID- 4334751 TI - Metabolic pools of polyphosphoinositides in rat brain. PMID- 4334753 TI - A rapid, simple method for isolating pinocytotic vesicles and plasma membrane of lung. PMID- 4334752 TI - Characterization of the mycoplasma membrane proteins. II. Solubilization and enzymic activities of Acholeplasma laidlawii membrane proteins. PMID- 4334754 TI - Studies on plasma membranes. XIV. Adenyl cyclase in plasma membranes isolated from rat and mouse livers and hepatomas, and its hormone sensitivity. PMID- 4334755 TI - Studies on plasma membranes. XV. A sex difference in alkaline phosphatase activities of plasma membranes isolated from rat liver. PMID- 4334756 TI - Preparation of a oubain-binding membrane fraction form brain. PMID- 4334757 TI - A simple method for the isolation of rat liver cell plasma membranes in isotonic sucrose. PMID- 4334758 TI - Volume increase in rat adrenocortical mitochondria by single ACTH administration. A stereological study. PMID- 4334759 TI - Diagnostic significance of symptomatology in brain stem ischaemic infarction. PMID- 4334760 TI - Arteriosclerosis and calcification. PMID- 4334761 TI - Endocrine function in normal and agalactic sows. PMID- 4334762 TI - Comparison of cysteine and tryptophan content of insoluble proteins derived from wild-type and mi-1 strains of Neurospora crassa. AB - The possibility of an amino acid substitution (cysteine for tryptophan) in a membrane protein of the [mi-1] strain of Neurospora crassa has been investigated in detail by using a double radioactive labeling procedure. Auxotrophic strains of Neurospora having wild-type [+] or [mi-1] cytoplasm have been grown under conditions which result in the specific labeling of protein tryptophan with (3)H and protein cysteine with (35)S. Although the least soluble 1 to 20% of the [mi 1] mitochondrial membrane protein was usually found to have a higher Cys/Trp ratio (ratio of cysteine plus half-cystine to tryptophan) than the corresponding [+] fraction, it has been shown that these differences were due mainly to the presence of differential amounts of a very insoluble, cysteine-rich (Cys-rich) material. The same Cys-rich material was found in variable amounts in both [+] and [mi-1] cultures, but the concentration was usually higher in the [mi-1] cultures. The Cys-rich material is clearly distinct from "structural protein" on the basis of amino acid composition and appears to have no direct relationship to the [mi-1] phenotype. In the absence of the Cys-rich material, no difference between the Cys/Trp ratios of corresponding [+] and [mi-1] membrane proteins could be detected. We conclude, therefore, that the previously postulated amino acid substitution of cysteine for tryptophan in [mi-1] membrane protein is incorrect. PMID- 4334763 TI - Ribose utilization by Veillonella alcalescens. AB - The utilization of ribose by Veillonella alcalescens has been further investigated. Nonfermentation of ribose is not a result of a phosphorylation lesion since ribose-phosphorylating activity was measured in cell extracts. Resting cells accumulated ribose-5-phosphate and nucleotides when (14)C-ribose was provided; no other sugar phosphates were detectable. Resting cells that were shifted to growth conditions polymerized rather than degraded the accumulated ribose compounds. Cell extracts contained a fructose diphosphate phosphatase. Ribose-5-phosphate, glucose-6-phosphate, and fructose-6-phosphate were not hydrolyzed. It is postulated that the nonfermentation of ribose is not due to any metabolic lesions, but is a consequence of metabolic control at the fructose diphosphate level of glycolysis. PMID- 4334764 TI - Freeze-etching of Azotobacter vinelandii: examination of wall, exine, and vesicles. AB - The structure of the cell wall, the arrangement of the cyst exine, and the origin and distribution of intine vesicles in Azotobacter vinelandii ATCC 12837 were examined by freeze-etching and conventional electron microscopic techniques. In the vegetative organism the cell wall appears to have a woven texture which disappears during cyst formation. The exine is composed of two different types of material: the outer layer is a fibrous, amorphous layer, and the numerous inner layers form the basic hexagonal structures which unite to form the cyst coat. The presence of intine vesicles in the encysting organism was confirmed in frozen etched cells. The appearance of frozen-etched cells and cysts and the distribution of capsular material indicate that extracellular polysaccharide is an important factor in cyst formation. PMID- 4334765 TI - Requirement of adenosine 3',5'-cyclic phosphate for formation of the phage lambda receptor in Escherichia coli. AB - Adenosine 3',5'-cyclic phosphate is indispensable for formation of the phage lambda receptor in Escherichia coli K-12. PMID- 4334766 TI - Action of haemophilus endodeoxyribonuclease on biologically active deoxyribonucleic acid. AB - An enzyme similar to that described by Smith and Wilcox (15) for Haemophilus influenzae which attacks foreign deoxyribonucleic acid (DNA) but not its own has been isolated and purified from H. parainfluenzae. The enzyme degrades foreign DNA to limited sizes and can destroy the transforming activity of H. influenzae and Bacillus subtilis DNA. The enzyme can also destroy the biological activity of H. influenzae phage and prophage DNA. On the other hand, the H. influenzae endodeoxyribonuclease can destroy the transforming activity of H. parainfluenzae DNA but not its own DNA. It also attacks B. subtilis DNA and its transforming activity. PMID- 4334767 TI - Adenyl cyclase hormone responses of certain human endocrine tumors. PMID- 4334768 TI - Changes in plasma 11-hydroxycorticosteroids after ACTH, insulin and dexamethasone in neonatal infants. PMID- 4334769 TI - Endocrine function in nineteen patients with empty sella syndrome. PMID- 4334770 TI - Plasma steroids in two subjects with ovarian androgen-producing tumors arrhenoblastoma and gynandroblastoma. PMID- 4334772 TI - The characterization of Varicella-zoster virus DNA. PMID- 4334771 TI - Chloroquine: protection against virus-induced cell damage without inhibition of virus growth. PMID- 4334773 TI - Stimulation of DNA synthesis and enhancement of murine sarcoma virus replication in mouse embryo cells by SV 40. PMID- 4334774 TI - Effect of Concanavalin A on cells infected with enveloped RNA viruses. PMID- 4334775 TI - Basis for the probit analysis of an interferon plaque reduction assay. PMID- 4334776 TI - Experimental study on the transmission of Sendai virus in specific pathogen-free mice. PMID- 4334777 TI - The effect of infection with different strains of Newcastle disease virus on cellular RNA and protein synthesis. PMID- 4334778 TI - Growth of Newcastle disease and herpes virus and interferon production in a monkey-mouse hybrid line. PMID- 4334779 TI - Electrophoretic analysis of membrane glycoproteins in normal and polyoma virus transformed BHK 21 cells. PMID- 4334780 TI - Polyoma virus basic proteins. PMID- 4334781 TI - Herpes simplex virus latency in cultured human cells following treatment with cytosine arabinoside. PMID- 4334782 TI - The structure of tobacco rattle virus ribonucleic acids: nature of the 3' terminal nucleosides. PMID- 4334783 TI - Stimulating effect of mouse sarcoma virus on the multiplication of Newcastle disease virus. PMID- 4334785 TI - Effect of vitamin D 3 on mitochondrial membrane of rat liver. PMID- 4334784 TI - Ultraviolet inactivation of Moloney leukaemia virus: relative target size required for virus replication and rescue of 'defective' murine sarcoma virus. PMID- 4334786 TI - Studies on D-tetrose metabolism. 3. Further studies on enzymes from beef liver involved in D-tetrose metabolism. PMID- 4334788 TI - [Treatment of myasthenia gravis--the clinical course and description of intractable cases]. PMID- 4334787 TI - [Classification of seizure in children and its treatment plan]. PMID- 4334789 TI - [Bacterial, mycoticand protozoan urogenital infections. Diagnosis and chemotherapy. International symposium in Florence, May 1971]. PMID- 4334790 TI - [Neurology]. PMID- 4334791 TI - [Diabetes mellitus]. PMID- 4334792 TI - [Myoclonus of the muscle with bulbar innervation following a mild closed cranial injury]. PMID- 4334793 TI - [Cylindroma in maxillofacial region]. PMID- 4334794 TI - [Serum antibodies against Epstein-Barr virus in infectious mononucleosis]. PMID- 4334795 TI - [Psycho-physio-pathological problems developed in recent work on sleep and dreams]. PMID- 4334796 TI - [Migristene for pre-medication and after-treatment in pneumoencephalography]. PMID- 4334797 TI - [Ultrastructure of dog eosinophils]. PMID- 4334798 TI - [Isolation of nuclei from muscle fibers. Evaluation of fraction purity and ATPase activity]. PMID- 4334799 TI - [A hormonally inactive insuloma]. PMID- 4334800 TI - Ultrastructure of Haller's organ in the tick Amblyomma americanum (L.). PMID- 4334801 TI - Ultrastructural studies on the adrenal medulla of golden hamster: origin and fate of secretory granules. PMID- 4334802 TI - [An electron-microscope study of "cellules speciales" in normally nourished and starved aeolids (Gastr. Nudibranchia)]. PMID- 4334803 TI - Post-coital ultrastructural changes in neurons of the suprachiasmatic nucleus of the rabbit. PMID- 4334804 TI - On the fine structure of alteration of the adrenal cortex in hypophysectomized rats. PMID- 4334805 TI - ["Thyroidectomy cells" and "castration cells" in the Japanese quail, Coturnix coturnix japonica. Ultrastructure and cytoenzymology]. PMID- 4334806 TI - [Electron microscopy studies on the epithelial structure of the gastrointestinal tract in Hirudo medicinalis L. II. Epithelium of the rectum]. PMID- 4334807 TI - Studies on growth of Finnish children from birth to 10 years. VII. Some parent child correlations for height, weight and skeletal age up to 10 years. A mixed longitudinal study. PMID- 4334808 TI - A useful roentgen sign in the diagnosis of localized bronchioloalveolar carcinoma. PMID- 4334809 TI - The neural mechanism of cyclopropane anesthesia in the rabbit. PMID- 4334810 TI - The effects of anesthetic agents of serum proline hydroxylase. PMID- 4334811 TI - The relationship of nutrition to fatty degeneration of the myocardium and kidney. PMID- 4334813 TI - [Gliomas of familial origin. Observations in 2 brothers]. PMID- 4334812 TI - Interstitial edema in valvular endocarditis. PMID- 4334814 TI - [Unusual pathology of the breast: 2 cases of chondrocarcinoma]. PMID- 4334815 TI - [Histochemical basis of compensatory reactions of the endocrine system in disorders of the sex steroid balance]. PMID- 4334816 TI - [Characteristics in the development of pneumoconiosis during the exposure to grain dust]. PMID- 4334817 TI - [Syndrome of minimal peripheral nerve dysfunction]. PMID- 4334818 TI - [Neurological findings in cystinuria]. PMID- 4334819 TI - Zinc deficiency in the chick: effect on tissue alkaline phosphatases. PMID- 4334820 TI - Oil droplet carotenoids of avian cones. I. Dietary exclusion: models for biochemical and physiological studies. PMID- 4334821 TI - Acute necrotizing encephalitis in a patient with Hodgkin's disease. A case report. PMID- 4334822 TI - [Electrophysiological data on cortical effects of neuroleptics and tranquilizers]. PMID- 4334823 TI - [Electron microscopic study of the morphology of thrombocytes and fibrin during intravenous administration of some antibiotics]. PMID- 4334824 TI - Familial active chronic hepatitis with hepatocellular carcinoma. Report of a case. PMID- 4334825 TI - [Enzyme-histological findings in the skeleton muscle in man. IV. Disuse atrophy]. PMID- 4334826 TI - [Plasma cortisol levels following intravenous injection of thyreotropin releasing hormone (TRH) in man]. PMID- 4334827 TI - The phospholipid composition of pig lung surfactant. PMID- 4334829 TI - Lipids of bovine thyroid. PMID- 4334828 TI - Liver phospholipids of rats fed a choline-deficient diet supplemented with choline or methionine. PMID- 4334830 TI - [Effects of neoplastic processes on free fatty acid concentration in the serum of children]. PMID- 4334831 TI - [Etiopathogenesis of diabetes. Role of adenosine cyclic 3'5' monophosphate in the islands of Langerhans]. PMID- 4334832 TI - [Malignant tumors of the ovary. Review of 163 cases from the University Hospital of Caracas and the Institute of Pathologic Anatomy of the Central University of Venezuela (1958-1968)]. PMID- 4334834 TI - [Direct lymphadenography of mediastinal nodes]. PMID- 4334833 TI - Occult duodenal Zollinger-Ellison tumors: their diagnosis by gastrin radioimmunoassay. PMID- 4334835 TI - Abnormal hemispheric blood flow and metabolism in cerebrovascular disease. I. Disordered patterns of hemispheric metabolism. PMID- 4334837 TI - [The effect of antineuraminidase serum on Sendai virus reproduction]. PMID- 4334838 TI - [Type-specific antigens of adenoviruses isolated from cattle]. PMID- 4334836 TI - [Chemotherapy of herpetic infections]. PMID- 4334839 TI - [The biological properties of 2 strains of adenovirus serotype 4]. PMID- 4334840 TI - [The infectious activity of newly synthesized paramyxovirus ribonucleoprotein]. PMID- 4334842 TI - [Uptake and utilization of phosphate compounds by phosphate deficient cells of Candida utilis. I. The uptake of inorganic pyrophosphate]. PMID- 4334841 TI - [The influence of the immunologic reactivity of rabbit leukocytes and macrophages on interferon production under the influence of herpesvirus]. PMID- 4334843 TI - [Lethal poisoning with hydrocyanic acid after ingestion of bitter almonds (Prunus amygdalus)]. PMID- 4334844 TI - An extracellular product of Mycobacterium phlei. 3. Relationship of production to microbial growth and evidence for a similar substance in other mycobacteria. PMID- 4334845 TI - Biological membranes: the dynamics of their organization. PMID- 4334846 TI - Circulation: overall regulation. PMID- 4334847 TI - Regulation of body fluids. PMID- 4334848 TI - Endocrine regulation of behavior. PMID- 4334849 TI - The adrenal cortex. PMID- 4334851 TI - Buoyant density gradient centrifugation of RNA and DNA in alkali iodide solutions. PMID- 4334850 TI - Regulation of cardiac contraction. PMID- 4334852 TI - Cytoplasmic control of protein synthesis in rat liver. PMID- 4334853 TI - Acid phosphomonoesterase of human prostate. Phosphate transfer reactions and comparison with alkaline phosphatase. PMID- 4334854 TI - The phytases. I. Lysolecithin-activated phytase from wheat bran. PMID- 4334855 TI - An NAD + -independent L-lactate dehydrogenase from Rhizopus oryzae. PMID- 4334856 TI - Concentrations of angiotensin-converting enzyme in tissues of the rat. PMID- 4334857 TI - Binding of NAD + and NADH to rabbit-muscle glyceraldehydephosphate dehydrogenase. PMID- 4334858 TI - Uridine diphosphate glucose dehydrogenase of rat tissue. PMID- 4334859 TI - Nicotinamide adenine dinucleotide kinase from Azotobacter vinelandii cells. A possible mechanism for the enzyme reaction. PMID- 4334860 TI - Immunochemical properties of purified polysaccharide fraction of Clostridium perfringens type A. PMID- 4334861 TI - Liver cell responses to the carcinogen 3'-methyl-4-dimethylaminoazobenzene. PMID- 4334862 TI - Binding of 14 C-labeled 4-nitroquinoline 1-oxide to DNA in vivo. PMID- 4334863 TI - Effects in vitro of 2-aminofluorene or electrophilic agents on hepatic microsomal N- and C-oxygenation of aromatic amines. PMID- 4334864 TI - [Occurrence of hemagglutination inhibiting antibodies against parainfluenza-3 virus in cattle in the county of Friesland]. PMID- 4334865 TI - [Dependence on central analgesics. 2. Relationship between alteration of the mitochondria of the zona fasciculata of the rat due to morphine dependence and corticosterone metabolism]. PMID- 4334866 TI - HGH and ACTH secretory responses to stress. PMID- 4334867 TI - The morphological substrate of the inhibition of insulin secretion by diazoxide. PMID- 4334868 TI - Further evidence for an inhibition of hepatic gluconeogenesis in hypoglycemia due to non-insulin-productin tumors. PMID- 4334869 TI - On the role of 3',5'-cyclic amp phosphodiesterase in insulin action on rat liver and adipose tissue. PMID- 4334870 TI - Phasic pattern of 17-ketosteroid- and hydroxyproline-excretion in urine of man after a single ACTH administration. PMID- 4334871 TI - The effect of an adenosine--3'5'--monophosphate diesterase inhibitor (aminophylline) on the insulin response to glucose infusion in prediabetic and diabetic subjects. PMID- 4334872 TI - Biological properties of a lipid mobilizing crude fraction of porcine hypothalamus. PMID- 4334873 TI - [Release of antidiuretic and corticotropic hormones during different types of stress in the rat]. PMID- 4334875 TI - The effect of dihydroergotamine on growth hormone--induced lipolysis in dogs. PMID- 4334874 TI - The effect of intestinal hormones upon lipolysis of isolated human fat cells. PMID- 4334876 TI - [Unbound fraction of plasma corticosterone and pituitary-adrenal response to stress during the post-natal period in rats]. PMID- 4334877 TI - Conservative treatment of uterovaginal prolapse and stress urinary incontinence. PMID- 4334878 TI - Nonchromaffin paraganglioma. 1. (No. 3 in a series). PMID- 4334879 TI - Age dependent resistance to polyoma and murine sarcoma viruses in mice. PMID- 4334880 TI - Surface antigen produced by herpes simplex virus (HSV). PMID- 4334881 TI - The antigens of varicella-zoster virus. PMID- 4334882 TI - Synthesis of rat IgE by aerosol immunization. PMID- 4334883 TI - [Encoding mechanism in taste]. PMID- 4334884 TI - [Sleep in parabiosis]. PMID- 4334885 TI - Infectious mononucleosis and other mono-like syndromes. PMID- 4334886 TI - Ethics of studies in anephric patients. PMID- 4334888 TI - Effect of REM sleep deprivation on learning and recall by humans. PMID- 4334887 TI - A simple slide test for demonstration of erythrocytic inclusions. PMID- 4334889 TI - Content analysis approach to visual scanning theory in dreams. PMID- 4334890 TI - [Classification and properties of Staphylococcus epidermidis]. PMID- 4334892 TI - [Effect of adaptation to intensive muscular activity on the functional state of skeletal muscle mitochondria]. PMID- 4334893 TI - [Cytochemical study of leishmania in culture]. PMID- 4334891 TI - [Regulation of lipolysis by hormonal and nonhormonal agents. A review of the subject]. PMID- 4334894 TI - [Electron-histochemical study of adenosine triphosphatase in the nuclei of normal and neoplastic liver cells in man and experimental animals]. PMID- 4334895 TI - [Enzmes of the oxidoreductase group in cell cultures infected with Rous sarcoma virus]. PMID- 4334896 TI - Meckel's diverticulum. PMID- 4334898 TI - The doctor talks about feminine hygiene. PMID- 4334897 TI - Dry skin and its consequences. PMID- 4334899 TI - Pathologic evaluation of breast carcinoma. PMID- 4334900 TI - Results of anterior transposition for ulnar neuropathy at the elbow. PMID- 4334901 TI - Infections with viruses and bacteria in intensively reared calves in Northern Queensland. PMID- 4334902 TI - Characterization of apolipoproteins in chicken serum and egg yolk. PMID- 4334903 TI - Measurements of the molecular weight variability of plasma low density lipoproteins among normals and subjects with hyper- -lipoproteinemia. Demonstration of macromolecular heterogeneity. PMID- 4334904 TI - Covalent coupling of ribonucleic acid to agarose. PMID- 4334905 TI - Relation of the respiratory chain-linked reduced nicotinamide--adenine dinucleotide dehydrogenase to energy-coupling site 1. PMID- 4334907 TI - On the mechanism of the pepsin-catalyzed hydrolysis of sulfite esters. PMID- 4334908 TI - Comparison of some reactions catalyzed by deoxyribonucleic acid polymerase from avian myeloblastosis virus, Escherichia coli, and Micrococcus luteus. PMID- 4334906 TI - Allosteric properties of muscle phosphofructokinase. 3. Thiol reactivity as an indicator of conformational state. PMID- 4334909 TI - Transfer ribonucleic acid methylases of nucleoli isolated from a rat tumor. PMID- 4334910 TI - Binding of complementary oligonucleotides to free and aminoacyl transfer ribonucleic acid synthetase bound transfer ribonucleic acid. PMID- 4334911 TI - Studies on uterine collagenase in tissue culture. I. Relationship of enzyme production to collagen metabolism. PMID- 4334912 TI - Studies on uterine collagenase in tissue culture. II. Effect of steroid hormones on enzyme production. PMID- 4334913 TI - Cyclic adenosine 3',5'-monophosphate in human lung. PMID- 4334914 TI - Stimulated formation of adenosine 3',5'-monophosphate by desipramine in brain slices. PMID- 4334915 TI - Role of cyclic 3',5'-amp in the action of physiological secretagogues on the metabolism of rat pancreas in vitro. PMID- 4334916 TI - Mode of action of a glucocorticoid on bovine intermediary metabolism. Possible role in controlling hepatic ketogenesis. PMID- 4334918 TI - Physicochemical properties of the DNA of herpes viruses. PMID- 4334917 TI - Threonine metabolism in a strain of Bacillus subtilis enzymic oxidation of 1 aminopropan-2-ol and aminoacetone. PMID- 4334919 TI - Studies on the relatedness of herpes viruses through DNA-RNA hybridization. PMID- 4334920 TI - An exonuclease of Neurospora crassa specific for single-stranded nucleic acids. PMID- 4334921 TI - Studies on transfer RNAs. I. A novel method for selective deamination of cytosine in oligonucleotides and transfer RNA. PMID- 4334923 TI - Platelet function and pyrophosphates in osteogenesis imperfecta. PMID- 4334922 TI - Methylation patterns of transfer RNA from ascites hepatomas. PMID- 4334924 TI - Streptozotocin-induced diabetes and islet cell alterations in rabbits. PMID- 4334925 TI - [Peripheral nerve, skin and muscle lesions following barbiturate poisoning]. PMID- 4334926 TI - [An unusual form of Cushing's syndrome in an elderly adult]. PMID- 4334927 TI - [Gas gangrene following intramuscular injection]. PMID- 4334928 TI - Transvenous adrenalectomy. PMID- 4334929 TI - Topical antibiotic and delayed primary closure in the management of contaminated surgical incisions. PMID- 4334930 TI - Latent herpes simplex virus from trigeminal ganglia of rabbits with recurrent eye infection. PMID- 4334931 TI - Autoradiographic localization of 3 H-GABA in rat retina. PMID- 4334932 TI - Synthesis of cell coat in normal and transformed cells. PMID- 4334934 TI - Peripheral entrapment neuropathies of upper extremity. PMID- 4334933 TI - Anti-neoplastic property of a crude extract from Paris formosana. PMID- 4334935 TI - [Angiotensin and kidney function]. PMID- 4334936 TI - [Sensitivity to pressor effects at late periods of time after onset of brain ischemia in rabbits]. PMID- 4334937 TI - [Angiotensin I-converting enzyme activity; determination methods and current topics]. PMID- 4334938 TI - [Significance of plasma renin substrate determination]. PMID- 4334939 TI - [Vascular action of angiotensin. Interaction of angiotensin and norepinephrine in the vascular bed]. PMID- 4334941 TI - [Significance of renin-angiotensin system in the development of hypertension- author's comments and viewpoint]. PMID- 4334940 TI - [Changes in fat granules of interstitial cell of the renal papilla in hypertensive animals]. PMID- 4334942 TI - [Significance of renin-angiotensin system in the development of hypertension- author's comments and viewpoint]. PMID- 4334943 TI - [Significance of renin-angiotensin system in the development of hypertension- author's comments and viewpoint]. PMID- 4334944 TI - [Significance of renin-angiotensin system in the development of hypertension- author's comments and viewpoint]. PMID- 4334945 TI - [Significance of renin-angiotensin system in the development of hypertension]. PMID- 4334947 TI - [Significance of renin-angiotensin system in the development of hypertension- author's comments and viewpoint]. PMID- 4334946 TI - [Significance of renin-angiotensin system in the development of hypertension- author's comments and viewpoint]. PMID- 4334948 TI - [Significance of renin-angiotensin system in the development of hypertension- author's comments and viewpoint]. PMID- 4334949 TI - [Significance of renin-angiotensin system in the development of hypertension- author's comments and viewpoint]. PMID- 4334950 TI - [Renin-angiotensin system and hypertension--etiological significance]. PMID- 4334951 TI - [Thecoma ovarii (2 case reports)]. PMID- 4334952 TI - [Changes in the activity of glucoso-6-phosphate enzymes in the kidneys after transfusion of incompatible blood]. PMID- 4334953 TI - [Results of histoenzymatic examination of the kidneys in nephrolithiasis]. PMID- 4334954 TI - [Specific antigens in virus-infected cells]. PMID- 4334956 TI - The progressive increase in estrogen production in human pregnancy: an appraisal of the factors responsible. PMID- 4334955 TI - Regulation of calcium transport in bone by parathyroid hormone. PMID- 4334957 TI - Effect of conformation on the binding of flavins to flavoenzymes. PMID- 4334958 TI - Flavin-radical-metal chelates. PMID- 4334959 TI - [Degeneration potential of pleomorphic parotis adenoma]. PMID- 4334960 TI - Insulin and glucose patterns in control subjects and in proved insulinoma. PMID- 4334962 TI - Dibutyryl cyclic AMP inhibition of epidermal cell division. PMID- 4334961 TI - Multiple clear-cell acanthoma and ichthyosis. PMID- 4334963 TI - Mediastinal emphysema complicating Stevens-Johnson syndrome. PMID- 4334964 TI - Pseudoainhum constricting bands of the extremities. PMID- 4334966 TI - Corticotropin dependency on zinc ions. PMID- 4334965 TI - Isolation, partial characterization of the cytoplasmic membrane fraction of Streptomyces albus G and DD-carboxypeptidase localization. PMID- 4334967 TI - Inhibition of hepatic lipogenesis by cyclic-3',5'-nucleotide monophosphates. PMID- 4334968 TI - Mediation by cyclic AMP of hormone-stimulated glycogenolysis in cultured rat astrocytoma cells. PMID- 4334969 TI - Synthesis and properties of poly 2'-fluoro-2'-deoxyuridylic acid. PMID- 4334970 TI - Isolation and some properties of cathepsin A from bovine spleen. PMID- 4334971 TI - Estrogen-binding properties of rat, mouse and man fetospecific serum proteins. Demonstration by immuno-autoradiographic methods. PMID- 4334972 TI - Variability in the catalytic and allosteric properties of rabbit liver fructose 1,6-diphosphatase. The prescence of tryptophan in homogeneous enzyme. PMID- 4334973 TI - Properties of the covalently bound flavin of chromatium cytochrome c-552 and its conversion to 8-carboxy-riboflavin. PMID- 4334974 TI - Cation requirements of isoleucyl-tRNA synthetase from Escherichia coli. PMID- 4334975 TI - The bound ferredoxin of chloroplasts: a role as the primary electron acceptor of photosystem I. PMID- 4334976 TI - Hysteretic substrate activation of bovine heart c-AMP phosphodiestrase. PMID- 4334977 TI - Histone phosphorylation and DNA synthesis are linked in synchronous cultures of HTC cells. PMID- 4334978 TI - A factor(s) required for activation of oxidative phosphorylation in protoplast ghosts of Mycobacterium phlei. PMID- 4334979 TI - Binding of vitamin D to its human carrier plasma protein. PMID- 4334980 TI - Cyclic 3'5'adenosine monophosphate inhibition of sulfation factor activity. PMID- 4334982 TI - The independence of adenosine-5'-diphosphate binding and the state of association of L-glutamate dehydrogenase. PMID- 4334981 TI - Colchicine and hormone secretion. PMID- 4334983 TI - Purification of the DNA polymerase of avian myeloblastosis virus. PMID- 4334984 TI - [Mechanism of the photosensitization by proflavine of DNA constituents: a study by electron paramagnetic resonance]. PMID- 4334986 TI - [Nervous coding]. PMID- 4334985 TI - Enzymic modification of chromosomal macromolecules. 3. The effect of adenine nucleotides on histone modification in chromatin and a possible influence of steroid hormones. PMID- 4334988 TI - [Typing of the foot-and-mouth disease virus]. PMID- 4334987 TI - [Comparative studies of the Aujeszky virus and the herpes simplex virus with the immunoelectrophoresis method]. PMID- 4334989 TI - [Tumors of trophoblastic origin. Anatomical study]. PMID- 4334990 TI - Some properties of the succinate dehydrogenase of Escherichia coli. PMID- 4334991 TI - Biosynthesis of cardiolipin in mitochondria. PMID- 4334992 TI - [Feedback mechanisms of the kidney]. PMID- 4334993 TI - [Paramagnetic centers of intact and germinating spores of Actinomyces streptomycini B-6]. PMID- 4334994 TI - [Detection of antibodies to T-antigens of different origin in sera of monkeys with Rous sarcoma and monkeys infected with adenovirus type 122]. PMID- 4334995 TI - Role of silicon activator in exoelectron emission from BeO. PMID- 4334996 TI - Interactions of tyrosyl transfer ribonucleic acid synthetase from Escherichia coli with its substrates. Inhibition by transfer ribonucleic acid. PMID- 4334997 TI - Structure of a low molecular weight form of glycogen isolated from the liver in a case of glycogen storage disease. PMID- 4334998 TI - Isolation of deoxyribonuclease II of rat liver lysosomes. PMID- 4334999 TI - Xanthine dehydrogenase and pteridine metabolism in Colias butterflies. PMID- 4335000 TI - Purification and properties of reduced diphosphopyridine nucleotide kinase from yeast mitochondria. PMID- 4335001 TI - Enzymatic synthesis of a tetraglycosylceramide by a galactosyltransferase from rabbit bone marrow. PMID- 4335002 TI - Reversible inhibition of adenine nucleotide translocation by long chain fatty acyl coenzyme A esters in liver mitochondria of diabetic and hibernating animals. PMID- 4335003 TI - The resolution of active and inactive xanthine oxidase by affinity chromatography. PMID- 4335004 TI - A mutation in a rous sarcoma virus gene that controls adenosine 3',5' monophosphate levels and transformation. PMID- 4335005 TI - Peripheral neuropathy as the initial manifestation of diabetes mellitus. PMID- 4335006 TI - The role of the developing kidney in the maintenance of internal stability. PMID- 4335007 TI - Relationship of physical particles of Yaba virus to infectivity as assayed by an improved focus-counting method. PMID- 4335008 TI - Serial passages of parainfluenza type 1 (HA-2) virus in the continuous cell lines from porcine, rabbit and green monkey kidneys using the trypsin-added systems. PMID- 4335011 TI - [Cortisone therapy in rheumatoid arthritis]. PMID- 4335009 TI - Effect of androgens on serum lipids and lipoproteins. PMID- 4335010 TI - Regulation of lipid metabolism in in vitro cultured minimal deviation hepatoma 7288C. PMID- 4335012 TI - Influence of x-irradiation of the adrenal gland on corticoid secretory activity in dogs. PMID- 4335013 TI - [Microangiopathic anemia and intravascular coagulation; association with muco cancer and treatment with heparin]. PMID- 4335014 TI - [Rarer tumors of the pancreas (hemangioma and nesidioma)]. PMID- 4335015 TI - [Infectivity for mice of ribonucleic acid extracted from chicken sarcoma induced with the Carr (Zilber) strain of Rous sarcoma virus -RSV-(Zilber) RNA-Carr-. II. Histoenzymological study]. PMID- 4335016 TI - Histological and histochemical studies of the lateral line canal organs of a freshwater teleost Saccobranchus fossilis. PMID- 4335017 TI - [Cushing's syndrome in a 22-month-old girl due to a left cortico-adrenal adenocarcinoma. Cure after surgical exeresis 4 years later]. PMID- 4335018 TI - [Cytotoxic reactions in cells infected with Sendai virus]. PMID- 4335019 TI - The influence of complement on cytomegalovirus neutralization by antibodies. PMID- 4335020 TI - Viscosity-density gradient for purification of foot-and-mouth disease virus. PMID- 4335022 TI - Studies with a rhinovirus of bovine origin. I. Growth in vitro of strain RS 3x. PMID- 4335021 TI - Characterization of a new canine herpes virus. PMID- 4335023 TI - An electron microscopic study of varicella skin lesions. PMID- 4335024 TI - Specific humoral immunity among volunteers with experimental adenovirus infection. PMID- 4335025 TI - Effect of chloroquine on the growth of animal viruses. PMID- 4335026 TI - Effects of dibutyryl cyclic adenosine 3',5'-monophosphate on pyruvate metabolism in rat adipose tissue. PMID- 4335027 TI - Lipid analysis of Aedes aegypti cells cultivated in vitro. PMID- 4335028 TI - Metabolism of diphosphoinositide and triphosphoinositide in Saccharomyces cerevisiae. PMID- 4335030 TI - On the mechanism for the depression of liver NAD by streptozotocin. PMID- 4335031 TI - The effects of drugs on Limulus cardioregulators. PMID- 4335029 TI - Isolation and characterisation of a mast cell degranulating substance from Ascaris suum. PMID- 4335032 TI - II. Cultivation of oncogenic viruses in mosquito cells in vitro. PMID- 4335033 TI - The effect of dehydrobenzperidol, chlorpromazine and reserpine on the pituitary adrenal system in human. PMID- 4335034 TI - The effect of cortisone treatment on the adenine nucleotide content of the salivary glands in the rat. PMID- 4335036 TI - [Virus-induced membrane fusion]. PMID- 4335035 TI - [Transformation of BSC 1 cells by SV40 virus: characteristics of the system and induction of cellular synthesis of viral antigens]. PMID- 4335037 TI - [The effect of rifampicin and distamycin A on DNA synthesis by RNA-dependent DNA polymerases of Rous sarcoma virus]. PMID- 4335038 TI - [Mucus-secreting cancer in an anal fistula]. PMID- 4335039 TI - [Pituitary insufficiency as a presenting symptom of carcinoma of the breast]. PMID- 4335040 TI - [Abnormal osmotic resistance of blood platelets in neoplastic diseases]. PMID- 4335041 TI - [Bile duct cancer in Israel]. PMID- 4335042 TI - Presence, significance, and inhibition of lysosomal proteoglycanases. PMID- 4335043 TI - "Trace" contamination of corticotropin and human growth hormone with vasopressin- clinical significance. PMID- 4335044 TI - Responses of plasma ACTH, GH, LH and 11-hydroxycorticosteroids to various stimuli in patients with Cushing's syndrome. PMID- 4335045 TI - Plasma corticotropin, cortisol and growth hormone responses to hypoglycemia in the morning and in the evening. PMID- 4335047 TI - Plasmodium hylobati: a malaria parasite of the gibbon. PMID- 4335046 TI - Effect of dietary fats on the serum lipoproteins in thyroidectomized dogs. PMID- 4335048 TI - Studies of the exoerythrocytic stages of simian malaria. VI. Plasmodium hylobati. PMID- 4335049 TI - Fine structure and development of the metacercarial cyst in Microphallus opacus (Ward, 1894). PMID- 4335050 TI - Protein bodies in Bryopsis hypnoides: their relationship to wound-healing and branch septum development. PMID- 4335051 TI - Inclusions with helical substructure in hepatocytic mitochondria of rhesus monkeys. PMID- 4335052 TI - Substructure of keratohyalin granules of the epidermis as revealed by high resolution electron microscopy. PMID- 4335053 TI - The spermatozoon of Arthropoda. 13. The cell surface. PMID- 4335054 TI - Intramitochondrial tubules in adrenal glands of rat. PMID- 4335055 TI - [Ultrastructure of disturbed erythropoiesis in congenital dyserythropoietic anemia]. PMID- 4335056 TI - [Virus-like particles in the leukemic cells of an infant: electron microscopic comparison with herpes simplex virus]. PMID- 4335057 TI - [Hepatolenticular degeneration and primary cancer of the liver]. PMID- 4335058 TI - [Behavior of poliomyelitis virus after ionising radiation]. PMID- 4335060 TI - [Malignant per- and post-operative hyperthermia]. PMID- 4335059 TI - [Metabolism of the genus Microsporum Gruby 1943. IV. Comparative studies of the degradation of triglycerides and waxes by 5 species of the genus Microsporum]. PMID- 4335061 TI - Medical management of simple familial rickets. PMID- 4335062 TI - Adenosine 3',5'-monophosphate: on its mechanism of action. PMID- 4335063 TI - Evidence for translation of viral-specific RNA in cells of a mouse mammary carcinoma. AB - A procedure is described permitting the detection of viral-specific RNA in a mouse mammary tumor. The method involves molecular hybridization with radioactively labeled DNA complementary to the RNA of the mouse mammary-tumor virus. RNA homologous to that of the mammary agent has been found in both the nuclear and polyribosomal fractions of tumor cells. The results imply that the oncogenic information is serving as messenger RNA that directs the synthesis of proteins required for virus production, and perhaps for the maintenance of the neoplastic state. The technology developed is immediately applicable to tumors of human origin. PMID- 4335064 TI - Role of calcium and adenosine-3':5'-cyclic monophosphate in controlling fly salivary gland secretion. AB - The action of 5-hydroxytryptamine (5-HT) on an insect salivary gland was associated with a rise in adenosine-3':5'-cyclic monophosphate (cAMP) concentration and an increase in calcium uptake. An increase in secretion induced either by 5-HT or exogenous cAMP required extracellular calcium. Both 5-HT and exogenous cAMP increased (45)Ca efflux from previously labeled glands, but only 5 HT caused an increase in calcium uptake. The transepithelial potential in this tissue became more negative after addition of 5-HT, but more positive after addition of cAMP. 5-HT and cAMP induced a more negative potential when calcium was removed from the medium. It was concluded that both calcium and cAMP serve as intracellular messengers when 5-HT acts upon fly salivary gland. PMID- 4335065 TI - Effect of corticotropin and desglycinamide 9 -lysine vasopressin on suppression of memory by puromycin. AB - The puromycin-induced blockade of expression of maze learning in mice can be prevented by subcutaneous administration of "Purified Cortrophin Gel" up to 3 days prior to training. A similar protective effect was not found when highly purified corticotropin was tested, but was observed after administration of desglycinamide(9)-lysine vasopressin. It appears that pressorpeptides are more potent protective agents than corticotropin when administered subcutaneously, and that vasopressin contamination of the commercial preparation was probably responsible for the protective effects previously reported. These experiments suggest that vasopressin and its congeners modify memory consolidation in such a way that the "expression" of memory becomes insensitive to puromycin. PMID- 4335066 TI - Expression of differentiated functions in hepatoma cell hybrids: induction of mouse albumin production in rat hepatoma-mouse fibroblast hybrids. AB - The synthesis of serum albumin has been studied in hybrids between well differentiated rat hepatoma cells, which synthesize serum albumin, and mouse fibroblasts (3T3) that do not synthesize albumin. By immunodiffusion techniques with noncrossreacting antisera, the production of both rat and mouse albumin by the hybrids has been examined. Karyologically identified hybrids were produced between 3T3 cells and cells of a 1s hepatoma (Fu5) clone, and of a 2s hepatoma (2s Fu5-5cl.lE) clone. Each of the 3T3 x Fu5 hybrids produces only rat albumin. Among five 3T3 x 2s Fu5-5cl.lE hybrid clones isolated, one produces both rat and mouse albumin, two produce only mouse albumin, and two do not produce rat or mouse albumin. PMID- 4335067 TI - Widespread presence, in chickens, of DNA complementary to the RNA genome of avian leukosis viruses. AB - DNA-RNA hybridization experiments have demonstrated the widespread presence in chickens of DNA complementary to the RNA of avian myeloblastosis virus. All apparently normal chicken embryos, or adult chickens that were tested, contained viral DNA in amounts ranging from 1.7 to 4.6 viral genome equivalents per cell. Embryos that were negative or positive for the group-specific antigen of avian leukosis viruses contained the same amount of viral DNA. Embryos from a strain of chickens free of leukosis viruses of groups A and B that develop 40% fewer spontaneous leukotic tumors than the original strain contained an average of 2.1 viral DNA equivalents per cell, whereas the original strain contained 3.2 viral DNA equivalents. By comparison, leukemic cells and cells infected with avian myeloblastosis virus or Rous sarcoma virus contained between 4 and 13 viral DNA equivalents. This study provides direct biochemical evidence for the presence in normal chicken cells of avian leukosis virus DNA that is inheritable and that represents either complete or incomplete viral genomes. PMID- 4335068 TI - Increased uptake of amino acids and 2-deoxy-D-glucose by virus-transformed cells in culture. AB - Transformed and nontransformed cells in tissue culture differ in their rate of uptake of certain nutrients, as determined by a polyester-coverslip technique. A 2.5- to 3.5-fold increased rate of uptake of alpha-aminoisobutyric acid, cycloleucine, and 2-deoxy-D-glucose was observed with polyoma virus-transformed baby hamster kidney (BHK) 21 cells and simian virus 40 (SV40)-transformed BALB/3T3 (mouse fibroblast) cells, compared to their nontransformed counterparts. Kinetic analysis suggested that the increased uptake by cells transformed with virus was associated with a 3-fold greater V(max), with no detectable changes in apparent K(m). Limited studies also revealed increased initial rates of uptake by murine sarcoma virus-transformed rat liver cells, as compared to the parental line. Exposure of cells to concanavalin A and wheat-germ agglutinin led to significant reductions in amino-acid uptake by both transformed and nontransformed cells; however, transformed cells showed a greater decrease in uptake after exposure to wheat-germ agglutinin. Increased initial rates of uptake of certain amino acids and sugars may be a feature common to transformed cells, compared to their parental control. PMID- 4335069 TI - Degradation of single- and double-stranded RNA by frog virus 3. AB - Purified preparations of frog virus 3 possess ribonuclease activities directed against single-and double-stranded RNA. Double-stranded RNAs isolated from purified reovirus type 3 and from HeLa cells infected with poliovirus and single stranded poliovirus RNA from purified virus are readily degraded by incubation with frog virus 3. The mode of action of the nucleases is endonucleolytic. Under the assay conditions used for the viral enzyme, crude extracts of uninfected HeLa, L, and baby hamster kidney cells did not show enzyme activity against double-stranded RNA but exhibited activity against single-stranded RNA. The dependence of the viral nucleases on divalent cations for optimal activity and the inhibition of the cleavage of single-stranded RNA by 0.2 M NaCl suggests that the enzymes are either virus-coded or virus-induced. PMID- 4335070 TI - Inhibition of DNA synthesis in animal cells by ethylene diamine tetraacetate, and its reversal by zinc. AB - During an investigation of the role of ions in growth regulation, it was found that ethylene diamine tetraacetate (EDTA) inhibits DNA synthesis about 10-fold in cultures of chick embryo cells, while ethylene glycol bis(beta-amino ethyl ether) N,N'-tetraacetate has no effect. RNA synthesis is only slightly inhibited by EDTA, and protein synthesis is unaffected. EDTA is inhibitory to DNA synthesis at a concentration much lower than that of either Ca(++) or Mg(++) present in the growth medium. The inhibition is prevented by the addition of Zn(++) at a much lower concentration than that of the EDTA. Other metal ions are ineffective. The inhibition of DNA synthesis only becomes apparent after more than 6 hr of incubation with EDTA, and descends to its final level by 15 hr. Complete restoration of the original rate of DNA synthesis is achieved within 8-10 hr by the addition of Zn(++). The low rate of DNA synthesis that occurs in a density inhibited culture, is refractory to further inhibition by EDTA. Rous sarcoma cells are less sensitive to inhibition by EDTA than normal cells, but the sensitivity of both is increased by reducing the concentration of Ca(++) in the medium. DNA synthesis in mouse 3T3 cells is also inhibited by EDTA. It is concluded that Zn(++) is a continuing requirement for DNA synthesis in cultured vertebrate cells, and it is suggested that the availability of Zn(++) within the cell may play a role in the regulation of cell multiplication. PMID- 4335071 TI - In vitro stimulation of sensitized lymphocytes by herpes simplex virus and vaccinia virus. AB - Splenic lymphocytes from rabbits immunized with herpes simplex virus (HSV) were incubated in vitro with ultraviolet light-inactivated HSV, and the degree of lymphocyte transformation was determined by measurement of the incorporation of [(3)H]thymidine into acid-insoluble material. Lymphocytes from immunized rabbits were stimulated as much as 30-fold, whereas lymphocytes from control rabbits were unaffected. Lymphocyte sensitization occurred within 3 days after immunization; sensitized lymphocytes could still be detected 120 days after immunization. The antigenicity of the ultraviolet light-inactivated crude virus pool was found to reside primarily in the virion. Infectious virus, in comparison with inactivated virus, produced less lymphocyte stimulation. Studies on the interaction of the humoral and cellular immune responses showed that incubation of anti-HSV antibody with HSV antigens did not reduce the capacity of the viral antigens to stimulate sensitized lymphocytes. Other experiments revealed that lymphocytes from both the spleen and peripheral blood of animals immunized with vaccinia virus could be stimulated by vaccinia, but not by HSV. Conversely, lymphocytes from animals immunized with HSV could not be stimulated by vaccinia. The transformation of sensitized lymphocytes by viral antigens appears to be a simple, highly specific, and quantitative in vitro technique for the study of the cellular immune response to viral infections. PMID- 4335072 TI - Polypeptides of avian RNA tumor viruses. V. Analysis of the virus core. PMID- 4335073 TI - Double-stranded replication form of poliovirus RNA: phenotype of heterozygous molecules. PMID- 4335075 TI - Amino acid composition of equine abortion (herpes) virus. PMID- 4335074 TI - Identification of transcriptive and replicative intermediates in Sendai virus infected cells. PMID- 4335076 TI - Variation in oncogenic and transforming potential of PARA (defective SV40) adenovirus 7. PMID- 4335078 TI - [Generalized adenosarcoma in a newborn]. PMID- 4335077 TI - [Some features of sporadic para-influenza infection in young children]. PMID- 4335079 TI - A study of degeneration and regeneration in the divided rat sciatic nerve based on electron microscopy. 3. Changes in the axons of the proximal stump. PMID- 4335080 TI - Electron microscopic and experimental studies of the pineal organ in the white crowned sparrow, Zonotrichia leucophrys gambelii. PMID- 4335081 TI - Blockade of hypothalamo-hypophyseal-adrenocortical mechanism caused by dexamethasone. PMID- 4335082 TI - Effects of theophylline on corticosterone secretory and adrenal growth response to ACTH in vivo. PMID- 4335083 TI - The effect of chronic droperidol treatment on pituitary-adrenocortical function in the rat. PMID- 4335084 TI - The significance of follow-up treatment for the hospital requirements of schizophrenic women. PMID- 4335085 TI - A fluorescent probe of the hydrogen ion concentration in ethylenediaminetetraacetic acid particles of beef heart mitochondria. PMID- 4335086 TI - Biochemical analysis of the naturally repaired sections of bacteriophage T5 deoxyribonucleic acid. 3. Nucleotide analysis of deoxyribonucleic acid synthesized under nonpermissive conditions. PMID- 4335087 TI - Structure of rat skin collagen 1-CB8. Amino acid sequence of the hydroxylamine produced fragment HA1. PMID- 4335089 TI - Inactivation of nicotinamide-adenine dinucleotide glycohydrolase from livers of different mammalian species by nicotinamide-adenine dinucleotide. PMID- 4335088 TI - The effect of temperature on the kinetics of adenosine diphosphoglucose pyrophosphorylase from Rhodospirillum rubrum. PMID- 4335090 TI - Rapid kinetic evidence for adduct formation between the substrate analog p nitroso-N,N-dimethylaniline and reduced nicotinamide-adenine dinucleotide during enzymic reduction. PMID- 4335091 TI - A disproportionation mechanism for the all-or-none dissociation of mercurial treated glyceraldehyde phosphate dehydrogenase. PMID- 4335092 TI - [Analysis of the activities of the Social Service Department of the University Hospital in Hradec Kralove in its 1st year]. PMID- 4335093 TI - [Principles of improved care for older and aged citizens following discharge from hospital]. PMID- 4335094 TI - Evidence for acute ACTH release by extrahypothalmic mechanisms. PMID- 4335095 TI - The involvement of cyclic AMP in the hormonal regulation of protein synthesis in rat adipocytes. PMID- 4335096 TI - Acute effect of gonadotrophins on the secretion of progestins by the rat ovary. PMID- 4335097 TI - Release of pre-formed free fatty acids from adipose tissue: acceleration by cyclic AMP. PMID- 4335098 TI - Persistence of a diurnal rhythm in hypothalamic corticotrophin-releasing factor (CRF) in the absence of hormone feedback. PMID- 4335099 TI - Action of KI on stimulated thyroid protein biosynthesis. PMID- 4335100 TI - Studies on the carbohydrate units of thyroglobulin. Structure of the mannose-N acetylglucosamine unit (unit A) of the human and calf proteins. PMID- 4335101 TI - Synthetic thyrotropin releasing factor as a test of pituitary thyrotropin reserve. PMID- 4335102 TI - Comparative thyroid uptake studies with 131 I and 99m TcO 4 - . PMID- 4335103 TI - Secretion of ACTH and -MSH by an adrenal medullary paraganglioma. PMID- 4335104 TI - Adrenocorticotropin measurement by competitive binding receptor assay. PMID- 4335105 TI - Deoxycorticosterone production and regulation in man. PMID- 4335106 TI - Studies of the mode of action of the sulfonylureas and phenylacetamides in enhancing the effect of vasopressin. PMID- 4335107 TI - A comparison of bioassay and radioimmunoassay for plasma corticotropin in man. PMID- 4335108 TI - Proinsulin and insulin content of subcellular fractions from an islet adenoma. PMID- 4335109 TI - [Pulmonary embolisms revealing visceral cancer]. PMID- 4335110 TI - The effect of cervical spinal section on the ability of morphine to elevate the jaw jerk threshold to electrical stimulation of the tooth pulp in cats. PMID- 4335111 TI - Degenerative and nondegenerative effects of 6-hydroxydopamine on adrenergic nerves. PMID- 4335112 TI - Cholinergic transmission in the hypoglossal reinnervated nictitating membrane of the cat: an enzymatic, histochemical and physiological study. PMID- 4335113 TI - Effect of chlorthalidone on blood vessels. PMID- 4335114 TI - Electron microscopic study on the xanthophore differentiation in Xenopus laevis, with special reference to their pterinosomes. PMID- 4335115 TI - Release of infectious bovine rhinotracheitis virus from productively infected bovine kidney cells: an electron microscopic study. PMID- 4335116 TI - The structure and development of the epidermis in sheep fetuses. PMID- 4335118 TI - Cytodifferentiation during spermiogenesis in Rhabditis pellio. PMID- 4335117 TI - Developmental studies in Drosophila. II. Ultrastructural analysis of the salivary glands of Drosophila pseudoobscura during some stages of development. PMID- 4335119 TI - An ultrastructural characterization of the endothelial cell in the rat liver sinusoid under normal and various experimental conditions, as a contribution to the distinction between endothelial and Kupffer cells. PMID- 4335120 TI - [Immediate repercussions of bronchography on ventilatory frunction]. PMID- 4335121 TI - [Case of Lowe's oculo-cerebro-renal syndrome with vitamin D-resistant rickets]. PMID- 4335122 TI - Serum enzymic activity of L-lactate: NAD oxidoreductase (LDH) and its variants in normal mice and in mice with leukaemia (L 14 AKR) and with ascitic sarcoma S 180. PMID- 4335123 TI - [Experimental neuron swelling for histoenzymatic studies]. PMID- 4335124 TI - [Methods of histological studies of peripheral nerves]. PMID- 4335125 TI - [Ultrastructural study of the perisinusoidal cells of the liver in 3 cases of mucopolysaccharidosis]. PMID- 4335127 TI - Effect of allobarbital on focal epilepsy in rats. PMID- 4335126 TI - [The viral problem in mammary tumors]. PMID- 4335128 TI - Heavy-particle therapy for acromegaly, Cushing's disease, Nelson's syndrome, and nonfunctioning pituitary adenomas. PMID- 4335129 TI - Pulmonary disease studied by electron microscopy: pathogenesis and pathophysiology. PMID- 4335130 TI - [In vitro polyoma virus transformation of cells of a tumor induced in hamsters by 20-methylcholanthrene]. PMID- 4335132 TI - In situ and pilot organ perfusion techniques for the study of metabolic dynamics. PMID- 4335131 TI - Liver perfusion in the study of hormone effects on the ionic content and membrane potential of liver cells. PMID- 4335133 TI - [Truncular paralysis caused by nerve compression in the forearm (median, cubital and radial nerves)]. PMID- 4335134 TI - Effect of antimycin A and 2-heptyl-4-hydroxyquinoline N-oxide on the respiratory chain of submitochondrial particles of beef heart. PMID- 4335135 TI - Characterization and quantitation of the apolipoproteins from human chyle chylomicrons. PMID- 4335136 TI - Role of molecular conformation in determining the electrophoretic properties of polynucleotides in agarose-acrylamide gels. II. PMID- 4335137 TI - Effect of allosteric ligands on the mechanism and stability of nicotinamide adenine dinucleotide specific isocitrate dehydrogenase from yeast. PMID- 4335138 TI - Compositional differences of lipid in transformed hamster fibroblasts. PMID- 4335139 TI - The metabolism of very low density lipoprotein proteins. I. Preliminary in vitro and in vivo observations. PMID- 4335140 TI - In vitro studies of phospholipid biosynthesis in Saccharomyces cerevisiae. PMID- 4335141 TI - Choline oxidation and labile methyl groups in normal and choline-deficient rat liver. PMID- 4335143 TI - On the apoprotein composition of human plasma very low density lipoprotein subfractions. PMID- 4335142 TI - An isomer of trisialoganglioside and the sturcture of tetra- and pentasialogangliosides from fish brain. PMID- 4335144 TI - Preparation and partial characterization of a lamellar body fraction from rat lung. PMID- 4335145 TI - [The cytochemistry of dehydrogenases in isolated nuclei]. PMID- 4335146 TI - [Participation of relatively high threshold afferents in the formation of the dorsal surface potential of the spinal cord]. PMID- 4335147 TI - [Renovascular hypertension in current practice. Indications for various diagnostic and prognostic studies]. PMID- 4335148 TI - Control of ACTH- and MSH-secretion by catecholaminergic neurones in the tuber cinereum. PMID- 4335149 TI - [2 cases of acute lepromatous abscess of the ulnar nerve]. PMID- 4335150 TI - [Megadolichocolon and acquired lesions of the myenteric plexus in the African (apropos of 36 cases)]. PMID- 4335151 TI - Acute respiraotry diseases in students at the University of the Philippines, 1964 69. AB - Acute respiratory infections have been found to be a common cause of morbidity in young adults in the tropical setting of the Philippines, with incidence rates equalling those of colder northern countries. Influenza outbreaks have occurred as part of a worldwide pattern and parainfluenza infections are common, as revealed by serological tests on such students. About half of the respiratory infections could be identified etiologically. In contrast, clinical infections from group A haemolytic streptococci, Mycoplasma pneumoniae, adenoviruses, and infections due to Epstein-Barr virus (infectious mononucleosis) were rare in this population. The role of prior immunity is discussed in relation to these patterns. PMID- 4335152 TI - [Action of rifampicin on the vesicular stomatitis virus]. PMID- 4335153 TI - [Application of the molecular hybridization technic in situ for the demonstration with the electron microscope, of vegetative replication of viral DNA in the papillomas induced with Shope virus in cottontail rabbits]. PMID- 4335154 TI - [Localization of polysaccharides in cells of spore-forming anaerobic bacteria]. PMID- 4335155 TI - [Relation between complementary chains in the molecules of the replicative form of encephalomyocarditis virus RNA]. PMID- 4335156 TI - [Study by the paramagnetic probe method of the mechanism of interaction with the substrate of cells of hydrocarbon-oxidizing mycobacteria]. PMID- 4335157 TI - Histochemical demonstration for the release of norepinephrine from the sympathetic nerves in the cat spleen. PMID- 4335158 TI - A new efferent pathway in the cockroach CNS. PMID- 4335159 TI - The effect of picrotoxin and strychnine upon inhibition of fusimotor neuron discharges caused by cutaneous fiber stimulation. PMID- 4335160 TI - Some properties of crystalline inclusion bodies in oocytes of Rana temporaria and Rana esculenta. PMID- 4335161 TI - Discrepancies between the sites of replication and cytocidal action of encephalitogenic viruses. PMID- 4335163 TI - Submicroscopic changes in synapses of the nervous system. PMID- 4335162 TI - [Importance and limitations of otofunctional examinations in the early diagnosis of occupational poisonings]. PMID- 4335165 TI - [Effect of a constant magnetic field on the state of the blood system in mice]. PMID- 4335164 TI - [State of the cholinergic system in rabbits during neural dystrophy]. PMID- 4335166 TI - [Thin-layer chromatographic-enzymatic detection of carbamates. 3]. PMID- 4335167 TI - Retinal anlage tumors. PMID- 4335168 TI - Effects of adrenergic agonists and antagonists on adenylate cyclase activity of dog heart and liver. PMID- 4335169 TI - Inhibition by dopamine of the hydro-osmotic response (water transfer) of the toad bladder to vasopressin. PMID- 4335170 TI - Effects of pilocarpine or arecoline administration on acetylcholine levels and serotonin turnover in rat brain. PMID- 4335171 TI - Neurogenic and vascular stores of histamine in the dog. PMID- 4335172 TI - Pharmacological studies on transmission in the central visual pathway in relation to effects of pentobarbital. PMID- 4335173 TI - Studies on drug-induced lipodosis. V. Changes in the lipid composition of rat liver and spleen following the administration of 4,4' diethylaminoethoxyhexestrol. PMID- 4335174 TI - Phospholipids of fish gills. PMID- 4335176 TI - Continuity of family-centered nursing care between the hospital and the home. PMID- 4335175 TI - Further evidence for the interconversion of monophosphoinositides in vivo. PMID- 4335177 TI - [Effect of anticonvulsants on the night sleep of epileptics]. PMID- 4335178 TI - [Motor axon reflexes]. PMID- 4335180 TI - [Significance of ribosomal RNA conformation in its degradation by rabbit reticulocyte ribosomal endonuclease]. PMID- 4335179 TI - [An intraneural ganglion of the ulnar nerve at the wrist]. PMID- 4335181 TI - [Influence of the adrenal gland on in vitro deiodination of L-diiodotyrosine]. PMID- 4335182 TI - Metabolic decomposition of chloramphenicol by Alcaligenes faecalis. PMID- 4335183 TI - Symbiotic relationship between Entamoeba histolytica and Bacteroides symbiosus. PMID- 4335184 TI - Effect of guanethidine on nerve cells and small intensely fluorescent cells in sympathetic ganglia of newborn and adult rats. PMID- 4335185 TI - Ocular pathology in fabry's disease. Histochemical and electron microscopic observations. PMID- 4335186 TI - Mammary tumor virus-associated antigenicity of L-1210 murine leukemia cells. PMID- 4335187 TI - Drug resistance of Salmonella enteritidis bacilli. PMID- 4335188 TI - Unsuspected etiology of lateral neck masses. Cat-scratch disease. PMID- 4335189 TI - Studies of microsomal cytochrome P-450 with isocyanide spin label. PMID- 4335191 TI - [Cl. welchii as a potential cause of food poisoning]. PMID- 4335190 TI - Characterization of lymphocyte-stimulating blood cell-agglutinating glycoproteins from red kidney beans (Phaseolus vulgaris). PMID- 4335192 TI - Infantile lactic acidosis due to hereditary fructose 1,6-diphosphatase deficiency. PMID- 4335194 TI - Infiltration of the capsule in pleomorphic adenomas of salivary gland. PMID- 4335193 TI - Estrogen action in vitro. Induction of the synthesis of a specific uterine protein. PMID- 4335195 TI - Specific laboratory diagnostics of serous meningitis enteroviruses and conditions determining their realiability in a non-epidemic period. PMID- 4335196 TI - [Metabolism of vasoactive substances in the lung]. PMID- 4335197 TI - Studies on the functional role of adenosine 3',5'-monophosphate, histamine and prostaglandin E 1 in the central nervous system. PMID- 4335198 TI - An electrophysiological study of transmission from intramural excitatory nerves to the smooth muscle cells of the chicken oesophagus. PMID- 4335199 TI - Further observation on the enhancement by morphine of the central descending inhibitory influence on spinal sensory transmission. PMID- 4335200 TI - Actions of certain polypeptides on frog spinal neurons. PMID- 4335201 TI - Metabolic evaluation of sexual dimorphism. II. Effects of epinephrine and dibutyryl 3',5' cyclic AMP on glucose oxidation. PMID- 4335202 TI - [Studies on the metabolism of ACTH, with special reference to ACTH inactivating factor]. PMID- 4335203 TI - [Experimental studies on the mechanism of ACTH secretion with special reference to the pattern of adenohypophyseal RNA, plasma ACTH activity and plasma corticosterone after various acute stimuli in rats]. PMID- 4335204 TI - [Experimental studies on the metabolic disturbance of myocardium with special reference to thyrotoxic heart and beri-beri heart]. PMID- 4335205 TI - Recovery of cytomegalovirus from the cervix in pregnancy. PMID- 4335206 TI - Trial of therapy and prospective study of nephroblastoma. PMID- 4335207 TI - [3 cases of gastric cancer found in the gyneco-obstetric department]. PMID- 4335208 TI - [From old volumes. 1913-1916]. PMID- 4335209 TI - [The renin-angiotensin-aldosterone system. Disorders and methods of clinical research]. PMID- 4335210 TI - [Behavior of adrenocorticotropic internal secretions in Cushing's syndrome]. PMID- 4335211 TI - [Pituitary-adrenal function in the cirrhotic patient]. PMID- 4335212 TI - [Adrenocortical sensitivity to exoenous ACTH following intensive short-term corticotherapy]. PMID- 4335213 TI - Benign tumors of the external auditory canal. PMID- 4335214 TI - [Effect of type of cell culture on reproduction of Herpesvirus at elevated temperatures]. PMID- 4335215 TI - [Comparative ultrastructure of viruses of camel pox, pox-like disease of camels ("auzdyk") and contagious ecthyma of sheep]. PMID- 4335216 TI - [Interferon and avian leukosis-sarcoma viruses]. PMID- 4335217 TI - [Cytoproliferative activity of viruses]. PMID- 4335218 TI - [Separation of viral and cellular polysomes by an immune serum]. PMID- 4335219 TI - [Antibody- and interferon-formation in chronic relapsing aphthous stomatitis]. PMID- 4335220 TI - [State of the liver and biliary tract in persons sustaining Botkin's disease]. PMID- 4335221 TI - [Sex chromatin and its clinical significance]. PMID- 4335223 TI - Studies of adrenocortical ultrastructure. I. Aldehyde perfusion fixation of the domestic fowl. PMID- 4335222 TI - [Histoenzymology of pancreatic phosphatases in experimental chronic pancreatitis]. PMID- 4335224 TI - [Cellular kinetics of epitheliomas]. PMID- 4335225 TI - The indirect hemagglutination test for amebiasis in patients with inflammatory bowel disease. PMID- 4335226 TI - [Study of penicillin-acylase produced by Erwinia aroideae]. PMID- 4335227 TI - [Isolation of Listeria monocytogenes in medium unfavourable to Streptococcus faecalis]. PMID- 4335228 TI - Some characteristics of nocturnal penile tumescence in young adults. PMID- 4335229 TI - [Cyclic 3'-5'-adenosine monophosphate potentiated by theophylline and regulation of water balance]. PMID- 4335230 TI - [Preliminary research on the lactic acid content of the rabbit lens during various phases of development]. PMID- 4335231 TI - [Quantitative modification of intranuclear rodlets of sympathetic neurons during electric stimulation]. PMID- 4335233 TI - Resting state of the myoneural junction in a hibernator. PMID- 4335232 TI - The effect of bicuculline upon synaptic inhibition in the cerebral and cerebellar corticles of the cat. PMID- 4335234 TI - [Viral etiology of some osteogenic osteosarcomas. Critical review]. PMID- 4335235 TI - Gastric and extragastric leiomyoblastomas: clinicopathologic study of 44 cases. PMID- 4335236 TI - Tumors of the major salivary glands in children. PMID- 4335237 TI - Alveolar cell carcinoma: does it exist? PMID- 4335238 TI - Rate of growth of soft tissue metastases of breast cancer. PMID- 4335239 TI - Primary adenocystic carcinoma (cylindromatous carcinoma) of the esophagus. PMID- 4335240 TI - Effect of beta-aminopropionitrile on tumor metastases in the rat. PMID- 4335241 TI - Production of interferon induced by hyaluronic acid from Rous sarcoma. PMID- 4335242 TI - Metabolic bone disease in children. PMID- 4335243 TI - Phospholipid composition of aqueous humor, plasma and lens in normal and alloxan diabetic rabbits. PMID- 4335244 TI - [Simultaneous microdetermination of phosphorus and halogens in organic compounds]. PMID- 4335245 TI - [Selective pancreatic arteriography. Its possibilities and limitations in the diagnosis of hypoglycemic insulomas]. PMID- 4335246 TI - Placental transmission of neutralizing antibodies to poliomyelitis virus. PMID- 4335247 TI - Pressor response to angiotensin and plasma renin activity in anephric patients. PMID- 4335250 TI - Fusion of human red blood cell membranes. PMID- 4335248 TI - Respiratory enzymes and mitochondrial morphology of HeLa and L cells treated with chloramphenicol and ethidium bromide. AB - Exposure of HeLa and L cells to chloramphenicol causes a progressive dose dependent decrease in cytochrome oxidase and succinate-cytochrome c reductase activities, concomitant with an increase in the amount of cytochrome c. At 2-3 days, the specific activities of the enzymes have fallen to about one-half of control values; the mitochondria appear swollen. By day 5, enzyme activities are about one-quarter of control values; the mitochondria are more swollen, with disorientation and disintegration of cristae. By day 6-8, after three generations, growth has stopped, enzyme activities are approximately the same as on day 5, and cytochrome c content has reached 170% of control value. Mitochondria show severe changes, cristae being affected more than peripheral inner membrane. The number of profiles continues to be nearly normal. After 30 days, cytochrome oxidase activity remains low but now there are mitochondria in intermediate and condensed configuration. There is a gradual accumulation in the cytoplasm of smooth membrane elements. If chloramphenicol is removed, cells recover. Ethidium bromide treatment for up to 8 days yields results virtually identical to those obtained with chloramphenicol. Cells treated with 10(-4)M KCN show a decrease in cytochrome oxidase activity to about one-third of control value and an elevated amount of cytochrome c. Only a small number of mitochondria appear damaged. Autochthonous mitochondrial syntheses appear to be essential for the organization of the cristae. When cytochrome oxidase activity is impaired, a regulatory mechanism for cytochrome biosynthesis geared to mitochondrial function may be lacking, resulting in an increase in cytochrome c content. PMID- 4335249 TI - Respiration and protein synthesis in Escherichia coli membrane-envelope fragments. IV. Chemical and cytological characterization and biosynthetic capabilities of fragments obtained by mild procedures. AB - Membrane-envelope fragments have been isolated from Escherichia coli by comparatively mild techniques. The use of DNAase, RNAase, detergents, sonication, lysozyme, and ethylenediaminetetraacetate were avoided in the belief that rather delicate, but metabolically important, associations may exist between the plasma membrane and various cytoplasmic components. The membrane-envelope fragments have been characterized in terms of their content of major chemical components as well as their electron microscope appearance. Fractions containing membrane-envelope fragments were found to possess appreciable DNA- and protein-synthesizing activities. The fragments were rich in membrane content as determined by reduced nicotinamide adenine dinucleotide (NADH) oxidase activity and deficient in soluble components as measured by NADH dehydrogenase activity. The particulate fraction obtained between 20,000 g and 105,000 g and usually considered a ribosomal fraction was rich in membrane content and had a relatively high capacity for DNA synthesis. Envelope fragments sedimenting at 20,000 g attained very high levels of incorporation of amino acids into protein. PMID- 4335251 TI - Localization of phosphatidic acid phosphatase activity in granular pneumonocytes. PMID- 4335252 TI - Phosphatases of epiphyseal cartilage studied by electron microscopic cytochemical methods. PMID- 4335253 TI - Reversible spinal cord trauma: a model for electrical monitoring of spinal cord function. PMID- 4335254 TI - Acute necrotizing encephalitis complicating bifrontal craniotomy and pituitary curettage. Report of two cases. PMID- 4335255 TI - Melanotic neuroectodermal tumor involving the cranium in infancy. Case report. PMID- 4335256 TI - [Clinical effects of rifampicin for pulmonary tuberculosis patients. 2. Results of rifampicin treatment for advanced pulmonary tuberculosis patients resistant to conventional antituberculous drugs]. PMID- 4335257 TI - [Allergic reactions due to Tetracosapeptide]. PMID- 4335258 TI - [Primary bronchial carcinoma in women (29 cases)]. PMID- 4335259 TI - [Pneumoconiosis due to diatomaceous earth]. PMID- 4335260 TI - Will the best model of breast cancer please come forward? PMID- 4335261 TI - The relevance of plant tumor systems to an understanding of the basic cellular mechanisms underlying tumorigenesis. PMID- 4335262 TI - Stability of the tumor phenotype in crown gall tumors of tobacco. PMID- 4335263 TI - [Tryptophan and sleep in chronic schizophrenics]. PMID- 4335265 TI - Fibrous histiocytoma of the pharynx. PMID- 4335264 TI - [Polygraphic evaluation of sleep disorders in psychiatry]. PMID- 4335266 TI - [Likelihood of a viral etiology in human cancers and leukemias]. PMID- 4335268 TI - Vesicular stomatitis virus (Indiana serotype): transovarial transmission by phlebotomine sandlies. AB - Transovarial transmission of vesicular stomatitis virus (Indiana serotype) by experimentally infected Lutzomyia trapidoi and Lutzomyia ylephiletrix to their progeny was demonstrated. Virus was recovered from all developmental stages; mean virus titers from egg to first generation adult showed a four-log increase, indicating that virus multiplication occurred during development of the sandflies. Virus titers in first generation adult females were comparable to those found in their parents. These infected female sandflies transmitted vesicular stomatitus virus Indiana by bite to susceptible animals and transmitted the virus transovarially to their offspring (second generation). Results demonstrate a possible mechanism for transmission and maintenance of this virus in nature without a vertebrate (heat) host reservoir. PMID- 4335267 TI - Capillary tube scanning applied to cell growth kinetics. AB - We have developed an optical scanning instrument which may become a valuable aid in a variety of cell studies. Cell multiplication can be readily monitored with the instrument. By varying the chemical environment in which the cells are tested, questions of research and clinical interest may be quickly and conveniently answered. It appears possible to investigate the chemotherapeutic value of experimental agents, and to scan the sensitivity of a given population of neoplastic cells to a variety of chemotherapeutic agents at several concentrations. The optical scanning system may also be used to investigate certain metabolic pathways of cells in tissue culture, to determine drug resistance, and to assess the effects of medium composition on cell growth. Our studies of BrdU resistance in mouse lymphoma cells were done primarily to demonstrate the potential of this optical scanning method, and we do not intend to continue the cytokinetic studies at present. We trust that others will be stimulated to investigate further applications of this instrumental approach to problems in cell biology. PMID- 4335269 TI - [Ultrastructure of vesicular stomatitis virus]. PMID- 4335270 TI - [Distribution of leukosis-sarcoma complex viruses among birds]. PMID- 4335271 TI - [Prevention of contagious pustular stomatitis (dermatitis) in sheep]. PMID- 4335272 TI - [Letters to the editor: fowl pox-diphtheria]. PMID- 4335273 TI - [Clinical evaluation of radiometric and rheometric methods in surgery of glial brain neoplasms]. PMID- 4335275 TI - [Autoradiographic study of the proliferative activity of some neuroectodermal human tumor]. PMID- 4335274 TI - [Results of surgical treatment of brain gliomas in relation to their topographic localization]. PMID- 4335276 TI - [Use of subcutaneous injections of oxygen in diseases of the peripheral nervous system]. PMID- 4335277 TI - [Carrier state of Entamoeba histolytica and its role in the development of intestinal diseases]. PMID- 4335278 TI - Hypersomnia and manic-depressive disease. PMID- 4335279 TI - Paget's disease of the male breast. PMID- 4335280 TI - The neurophysiology of learning. PMID- 4335281 TI - Recent advances in management of functioning islet cell tumor. PMID- 4335282 TI - [Paraganglioma (a histologic and cytologic picture)]. PMID- 4335283 TI - [Photo-optical and electron microscopic detection of glucose-6-phosphatase in the liver]. PMID- 4335284 TI - Studies on equine herpesviruses. 3. The incidence in Queensland of three different equine herpesvirus infections. PMID- 4335285 TI - Role of zinc in horse liver alcohol dehydrogenase. Coenzyme and substrate binding. PMID- 4335286 TI - Role of zinc in horse liver alcohol dehydrogenase. Influence on structure and conformational changes. PMID- 4335288 TI - Lysine-rich histone phosphorylation. A positive correlation with cell replication. PMID- 4335287 TI - Allosteric nature of thermostable phosphofructokinase from an extreme thermophilic bacterium. PMID- 4335289 TI - A calorimetric study of the binding of carbon monoxide to myoglobin. PMID- 4335290 TI - m-Hydroxybenzyl alcohol dehydrogenase from Penicillium urticae. PMID- 4335291 TI - Effect of N,N'-dicyclohexylcarbodiimide and other carbodiimides on electron transfer catalyzed by submitochondrial particles. PMID- 4335292 TI - Nucleotide sequence from the 5' end to the first cistron of R17 bacteriophage ribonucleic acid. PMID- 4335293 TI - Physicochemical studies on the lactate dehydrogenase of Streptococcus cremoris US3: the effects of modifiers. PMID- 4335294 TI - Inhibition of malate dehydrogenase by platinum(II) complexes. PMID- 4335295 TI - Activation of glutamate dehydrogenase from Blastocladiella emersonii by AMP. PMID- 4335296 TI - Iron absorption in Indians studied by whole body counting: a comparison of iron compounds used in salt fortification. PMID- 4335297 TI - Slow rate of haemichrome formation from oxidized haemoglobin Bart's (4 ): a possible explanation for the unequal quantities of haemoglobins H ( 4 ) and Bart's in alpha-thalassaemia. PMID- 4335299 TI - Herpes encephalitis in pregnancy. PMID- 4335298 TI - Beclomethasone dipropionate: a new steroid aerosol for the treatment of allergic asthma. AB - Beclomethasone dipropionate was used in pressurized aerosols for the treatment of 60 cases of chronic allergic asthma for up to 15 months. Twenty-eight out of 37 cases were transferred to this treatment after being dependent on oral steroids for up to 16 years. Nineteen out of 23 other asthmatics not dependent on steroids were also completely controlled. No biochemical evidence of adrenal suppression was found. Steroid withdrawal symptoms were often a problem, suggesting absence of systemic absorption. The precise mode of action and metabolic fate of this corticosteroid are not yet known. PMID- 4335300 TI - [New perspectives in the treatment of corneal ulcers]. PMID- 4335301 TI - [Testicular cytochemistry: phosphatase activities due to intrinsic substrates]. PMID- 4335302 TI - [Pasteurella pestis enzymes. Changes in concentrations of glucose-6-dehydrogenase as a function of the culture medium]. PMID- 4335303 TI - [Studies of oxidation in vitro of dopamine by the heart and nerve ganglia of the snail, Helix pomatia (L.): cytochrome oxidase]. PMID- 4335305 TI - Induction of testis alcohol dehydrogenase in prepubertal rats. I. The effects of human chorion gonadotropine (HCG), theophylline, and dibutyryl cyclic AMP. PMID- 4335304 TI - Terminal deoxyribonucleotidyltransferase from nuclei of rat intestinal mucosa. PMID- 4335306 TI - Effect of increased sodium ion on arterial sodium and reactivity. PMID- 4335307 TI - Effect of guanidine and germine on the neuromuscular block of botulism. PMID- 4335308 TI - Clinical evaluation of cortisporin otic solution for diffuse infections external otitis. PMID- 4335309 TI - Site of action of 3',5'-cyclic adenosine monophosphate in production of tryptophanase in Escherichia coli. AB - 3',5' cyclic-AMP (cAMP) will stimulate the rate of tryptophanase synthesis in Escherichia coli cultures induced with tryptophan. Adding cAMP after the initiation of messenger RNA synthesis was blocked by rifampicin, did not stimulate tryptophanase synthesis. This indicates that cAMP acts at initiation of either transcription or translation and not at the level of chain elongation of either the messenger or the polypeptide chain. PMID- 4335310 TI - [Transformation of human embryo cells by x-irradiation and rous sarcoma virus in vitro]. PMID- 4335311 TI - [Semi-quantitative analysis of urinary HCG by Luteonosticon]. PMID- 4335312 TI - [Pathological study of toxic polyneuropathy. 3. Light and electron mcroscopic observations on regeneration of rat peripheral nerves in methyl mercury poisoning]. PMID- 4335313 TI - The effect of ascites fluid of rat ascites hepatoma on drug metabolizing enzymes of rat liver microsomes. PMID- 4335314 TI - Serological studies on herpes simplex viruses by neutralization kinetic test. PMID- 4335315 TI - [Crystallographic analysis of lung and lymph node tissue]. PMID- 4335316 TI - [Internal medicine on the molecular level]. PMID- 4335317 TI - Sugar and amino acid transport by cells in culture--differences between normal and malignant cells. PMID- 4335318 TI - Uncertain role of cAMP in platelet function. PMID- 4335319 TI - Gestational trophoblastic disease (1965-1970) Victoria General Hospital, Halifax, Nova Scotia). PMID- 4335320 TI - Cytochrome oxidase activity of the kidney during development. PMID- 4335321 TI - Pesticide residues in food. Report of the 1970 Joint Meeting of the FAO Working Party of Experts on Pesticide Residues and the WHO Expert Committee on pesticide residues. PMID- 4335322 TI - [Coincidence of cancer and leukemia]. PMID- 4335323 TI - Interferon and antibody production in inbred mice infected with the Rauscher virus. PMID- 4335324 TI - The effect of theophylline upon induced -galactosidase synthesis in Escherichia coli. PMID- 4335325 TI - Timing the transfer of information between hemispheres in man. PMID- 4335326 TI - Inhibition by 3'-5'-cyclic AMP of luteinization induced by intrafollicular injection of luteinizing hormone. PMID- 4335327 TI - Exchange of cytoplasm between cells of the membrana granulosa in rabbit ovarian follicles. PMID- 4335328 TI - The Third Annual Carl G. Hartman Lecture. Brain, pituitary gland, and the ovarian cycle. PMID- 4335329 TI - [Importance of cardiovascular reactions in appraisal of the ganglionic effects of angiotensin]. PMID- 4335330 TI - [On dephosphorylation of acetylphosphate and carbamylphosphate in hepatocytes]. PMID- 4335331 TI - [Attempted correlations of the effects of gamma-phenyl-delta-beta-gamma butenolides on some enzyme activities and an electronic factor]. PMID- 4335332 TI - Cardiofacial syndrome. Report of two cases of congenital heart disease with congenital unilateral partial facial weakness. PMID- 4335333 TI - [Nuclear bodies in cat sympathetic neurons and change in their frequency under the influence of reserpine]. PMID- 4335334 TI - [Effect of sleep on certain ventilatory dysrhythmias in children and adolescents]. PMID- 4335335 TI - [Serum esterases and aflatoxin]. PMID- 4335336 TI - Infectious bovine rhinotracheitis virus in bovine kidney cells. II. Virus development and ultrastructural alterations in cultured cells. PMID- 4335337 TI - The effects of gold thioglucose on mouse fibroblasts in vitro. Morphological and laser microprobe studies. PMID- 4335338 TI - Accumulating filaments and other ultrastructural aspects of declining cell cultures derived from human breast tumors. PMID- 4335339 TI - Comparative complement-fixation studies with subtype strains of foot-and-mouth disease virus. AB - A comparison was made between a macrotechnique in tubes and a microtechnique in plastic plates for complement-fixation tests, using strains of three subtypes of the Asia 1 type of foot-and-mouth disease (FMD) virus. The results obtained with these techniques were found to be comparable and delineated the antigenic relationships of the three strains employed. The microtechnique was considered to be both economical with reagents and capable of similar accuracy and reproducibility to that of the standard method in tubes. It was concluded that the antigenic analysis of subtype strains of FMD virus can be conveniently carried out by the use of the microtechnique as described. PMID- 4335340 TI - Comparison of Tanapox virus and Yaba-like viruses causing epidemic disease in monkeys. AB - The virus of Tanapox isolated from the lesions of patients during an outbreak of mild disease in Africa has been found to be indistinguishable in its biological and serological properties from a virus isolated from outbreaks of a pox virus infection in monkeys in primate centres in America. The natural hosts of this virus are believed to be African monkeys and ;Tanapox virus' is proposed as a suitable designation for the virus. PMID- 4335341 TI - Detection of Bordetella pertussis antibodies in human sera by complement-fixation and immunofluorescence. AB - The complement-fixation test, as commonly used in the diagnosis of viral infections, was studied for its possible application to the diagnosis of whooping cough and the detection of antibody following pertussis vaccination. The results were compared with those obtained in parallel immunofluorescence tests. CFTs were performed on sera from 41 patients with whooping cough (Bordetella pertussis isolated), 125 vaccinated persons, and 618 controls; parallel tests by IF were made on sera from 24 cases of whooping cough, 36 vaccinated persons and 37 controls. Results of both tests correlated closely and showed that titres of diagnostic significance were seldom found in control sera. They also showed that, in patients suffering from whooping cough, antibody in a single specimen or a rise in antibody between paired sera was almost always demonstrated. Titres in general were lower in infants less than 6 months of age. IgG antibodies were involved in both tests. Although the number of sera tested was small both tests appear to be reliable as means of demonstrating the presence of antibody formed during the course of infection and after vaccination. PMID- 4335342 TI - [Clinicopathological studies on primary brain tumors from the histopathological view points]. PMID- 4335343 TI - Mutants of Herpes simplex virus. I. Isolation and properties of mutants characterized by plaque size and cytopathogenicity. PMID- 4335344 TI - Factors affecting pathogenicity of Serratia marcescens for mice. PMID- 4335345 TI - Wilms' tumour. PMID- 4335346 TI - Total care includes insight into cultural background. PMID- 4335347 TI - Maladies of derepression. Pathological, often monoclonal, derepression of protein forming templates. PMID- 4335348 TI - [Nitrofurantoin polyneuropathy]. PMID- 4335349 TI - [Practical application of the indirect immunofluorescence technique for the diagnosis of parasitic diseases in persons returning from the tropics. I. Immunofluorescence antibody test for malaria and amebiasis]. PMID- 4335350 TI - Effect of estrogen administration upon ceruloplasmin and copper concentrations in rat serum. PMID- 4335351 TI - [Bovine herpes mammillitis (BHM)]. PMID- 4335352 TI - [Differentiating and extinguishing inhibition in dogs following destruction of the caudate nuclei]. PMID- 4335353 TI - Plasma cortisol, corticosterone and non-protein-bound cortisol in extra-corporeal circulation. PMID- 4335354 TI - Effects of partial hypothalamic deafferentations on adrenocortical responses. PMID- 4335355 TI - Experimental lung silicosis. Evolution of functional, biochemical, and morphological changes in the rat. PMID- 4335357 TI - Acetazolamide dysmelia in rats. PMID- 4335358 TI - The distribution of lipoprotein lipase in tissues of the domestic fowl and the effects of feeding and starving. PMID- 4335356 TI - Malnutrition and peripheral neuropathies. PMID- 4335359 TI - Factors determining myocardial oxygen consumption (MVO 2 ) during elevation of aortic blood pressure. 1. Relation between MVO 2 and changes in mechanical performance at control and high levels of adrenergic activity. PMID- 4335360 TI - Factors determining myocardial oxygen consumption (MVO 2 ) during elevation of aortic blood pressure. 2. Relation between MVO 2 and free fatty acids. PMID- 4335361 TI - Chronic hypertension in rabbits induced by bilateral placement of rigid casts around the carotid sinus regions. PMID- 4335362 TI - Effects of ethanol on membrane lipids. II. Changes in the content and metabolism of aldehydogenic lipids in mouse total liver, mitochondria and microsomes. PMID- 4335364 TI - The lipid components of the plasma, liver and ovarian follicles in the domestic chicken (Gallus gallus). PMID- 4335365 TI - Effects of pentachlorophenol on enzymes involved in energy metabolism in the liver of the eel. PMID- 4335366 TI - Drug-induced depression and tryptophan metabolism. PMID- 4335367 TI - Radioiodine uptake by thyroid during long-term administration of theophylline in rats. PMID- 4335368 TI - The effect of ACTH and cyclic adenosine-3',5'-monophosphate on adrenal lipase activity in rats. PMID- 4335369 TI - Effect of hydrocortisone and ACTH on serum trypsin-inhibitory activity and antibody level following injection of Salmonella antigen in rabbits. PMID- 4335370 TI - Latent viral infection in transmission of foot-ana-mouth disease by contact between infected and susceptible cattle. PMID- 4335371 TI - The spectrum of infections with Epstein-Barr virus: a hypothesis. PMID- 4335372 TI - [Electron microscopic studies of the joint tissues under the normal and pathologic conditions. 2. Pathologic joint tissues (4). Is synovial sarcoma of mesenchymal or epithelial origin?]. PMID- 4335373 TI - [Inflammatory paralysis of the larynx]. PMID- 4335374 TI - Antitumor agents. I. Augustibalin, a new cytotoxic sesquiterpene lactone from Balduina angustifolia (Pursh.) Robins. PMID- 4335375 TI - Antitumor agents. II. Eupatolide, a new cytotoxic principle from Eupatorium formosanum HAY. PMID- 4335376 TI - Canine adenovirus nephritis. PMID- 4335377 TI - Feline mammary tumours. PMID- 4335379 TI - [Neuropathology of cytomegalovirus infection--with special reference to a case of necrotizing encephalitis with cerebral cytomegalic inclusion disease]. PMID- 4335378 TI - [Autopsy case of herpes encephalitis in an infant]. PMID- 4335380 TI - [Neuropathology of cytomegalovirus infection]. PMID- 4335381 TI - Tetracycline-induced fluorescence of laryngeal, pharyngeal, and oral cancer. PMID- 4335382 TI - Electrophysiologic study of reinnervated laryngeal motor units. PMID- 4335383 TI - [Ultrastructure of cells of the 37RC line infected with poliovirus. II. Late phase]. PMID- 4335384 TI - [Epidemiological study of Japanese encephalitis in Hokkaido. 1. Historical review of the occurrence of Japanese encephalitis in man and domestic animals]. PMID- 4335385 TI - [Epidemiological study of Japanese encephalitis in Hokkaido. 2. serological survey of Japanese encephalitis virus infection for residents of Hokkaido]. PMID- 4335386 TI - Leukemia, lymphoma, and osteosarcoma induced in the Syrian golden hamster by simian virus 40. AB - Leukemia, lymphoma, and osteogenic and anaplastic sarcomas develop in Syrian golden hamsters inoculated intravenously at 3 weeks of age with simian virus 40, which is a popova virus. Previously, only RNA and herpes DNA viruses have been recognized as capable of inducing leukemia and lymphoma in mammals. The significance of these findings is emphasized in relation to the nature of viral agents that may be involved in analogous diseases of man. PMID- 4335387 TI - Hormone-calcium interactions with the plasma membrane of rat liver cells. AB - The binding constants and the number of binding sites for insulin, glucagon, epinephrine, cyclic adenosine monophosphate, and calcium ions for the plasma membrane of rat liver were determined by Scatchard plots. The plots are biphasic or multiphasic, an indication of at least two types of binding sites for each ligand. At least three types of binding sites were found for insulin. In the concentration range of 10(-6) to 10(-8) molar, glucagon, epinephrine, and hydro cortisone increased calcium ion binding to the plasma membrane, whereas insulin decreased this binding. At hormone concentrations of 10(-6) to 10(-7) molar, glucagon was the most effective in increasing calcium binding, but at a hormone concentration of 10(-8) molar, hydrocortisone was the most effective in stimulating calcium binding. Adenosine triphosphate reversed the effect of insulin and inhibited the effect of the other hormones. These studies suggest a relation between hormones and calcium with respect to membrane structure and function. PMID- 4335388 TI - Molecular differentiation of several enzymes in early human embryos. PMID- 4335391 TI - Cell hybridization and tumor viruses. PMID- 4335392 TI - Sendai produced somatic cell hybrids between L cell strains and between liver and L cells. PMID- 4335393 TI - Cytohormonal studies in arrhenoblastoma. PMID- 4335394 TI - Cytologic aspects of bronchial brushing in a community hospital. PMID- 4335395 TI - Calcified (Psammoma) bodies in alveolar cell carcinoma of the lung. PMID- 4335396 TI - Alveolar cell carcinoma of the lung: an ultrastructural study of the cancer cells detected in the pleural fluid. PMID- 4335397 TI - [Primary cancer of the liver. Clinical study of 53 cases]. PMID- 4335398 TI - Production of interferon by the Cal-1 and turkey herpesvirus strains associated with Marek's disease. PMID- 4335399 TI - Production of circulating and cell-bound interferon in chickens by type 1 and type 2 plaque-producing agents of the Cal-1 strain of Marek's disease herpesvirus and herpesvirus of turkeys. PMID- 4335400 TI - Localized colitis cystica profunda, a benign lesion simulating malignancy. PMID- 4335401 TI - [Ascitic tumor produced by BHK-21 cells (clone 13) in hamsters exposed to whole body roentgen irradiation]. PMID- 4335402 TI - Interrelations of dietary calcium with phytates, phosphates and fats. PMID- 4335404 TI - Effects of some chemical radioprotectors on mouse liver NAD+ and NADH levels. PMID- 4335403 TI - An acute inflammation induced by inorganic pyrophosphate and adenosine triphosphate, and its inhibition by cyclic 3',5'-adenosine monophosphate. PMID- 4335405 TI - Potential coenzyme inhibitors. V. The synthesis and some properties of 4 methylnicotinamide adenine dinucleotide. PMID- 4335407 TI - Metabolism of drugs by isolated hepatocytes. PMID- 4335406 TI - Effects of propranolol on heart muscle mitochondria. PMID- 4335408 TI - Adrenergic receptors in human adipocytes--divergent effects of adenosine 3',5' monophosphate and lipolysis. PMID- 4335409 TI - Action of dopamine and noradrenaline on synaptic transmission in sympathetic ganglia of brown fat. PMID- 4335410 TI - The effect of (+)-catechin on the hepatic level of ATP and the lipid content of liver during experimental steatosis. PMID- 4335411 TI - Evaluation of enterovirus immune horse serum pools for identification of virus field strains. AB - Immune horse sera to 42 enterovirus immunotypes were pooled according to the Lim Benyesh-Melnick and the "intersecting serum" schemes. Each serum was diluted in the pools to contain 50 antibody units. After it was established that the pools correctly neutralized prototype virus strains, they were evaluated in tests against 273 enterovirus field strains representing most of the viral types included in the pools. With test virus doses of 10-100 TCD(50), most of the poliovirus and coxsackievirus field strains were correctly identified in both schemes, but a number of the echoviruses were neutralized by heterotypic pools, particularly in the Lim Benyesh-Melnick scheme. However, at higher test virus doses of 320-3200 TCD(50), little heterotypic neutralization occurred in either scheme, and 93-94% of the virus field strains were correctly identified in each scheme. With these larger virus doses, breakthrough tended to occur in homologous pools by the 7th day, but rarely by the 5th day. Since the Lim Benyesh-Melnick pool scheme employs 8 pools as compared with 13 for the intersecting serum scheme, and since the two schemes were equally satisfactory for identifying virus field strains at test virus doses of 320-3200 TCD(50), immune horse sera will be pooled by the former scheme, thus utilizing fewer pools, for distribution to qualified viral diagnostic laboratories. PMID- 4335412 TI - Procedure for simultaneous determination of secretion rates of deoxycorticosterone and corticosterone by double-isotope derivative assay. PMID- 4335413 TI - The interaction of procaine with the nonmyelinated nerve axon. PMID- 4335414 TI - Effect of chloramphenicol on enzyme synthesis and growth of mammalian cells. PMID- 4335415 TI - DDT-induced stimulation of key gluconeogenic enzymes in rat kidney cortex. PMID- 4335417 TI - Isolation in newborn mice of tumour cell variants from a polyoma-transformed non malignant cell line. PMID- 4335416 TI - Studies on a viral nephroblastic nephroblastoma of the chicken: an electron microscope comparison of the sequence of development of the virions in different organs. PMID- 4335418 TI - Studies on the anti-tumour activity of aliphatic aldehydes. V. Preferential inhibition of protein synthesis in normal or neoplastic tissues in relation to molecular structure. PMID- 4335419 TI - Cell-mediated immunity in polyoma oncogenesis. PMID- 4335420 TI - Control of cholesterol synthesis in hepatomas: absence of diurnal rhythm in hepatomas 7794A and 9618A. PMID- 4335422 TI - [Symmetrical calcification of the arcus iliopectinei]. PMID- 4335421 TI - [The radiological diagnosis of renal trauma]. PMID- 4335423 TI - [Bilateral occurrence of Konig's osteochondritis dissecans of the talus as observed in adults]. PMID- 4335424 TI - [Special radiography of the shoulder joint and the subcaput humerus using a hollow anode tube]. PMID- 4335425 TI - [Lymphogranuloma of the breast]. PMID- 4335426 TI - [Decrease of Ga 67 -citrate storage following chemotherapy]. PMID- 4335427 TI - [The coronary circulation and vascular disease. II. Functional evaluation of extra-mural coronary stenosis in man]. PMID- 4335429 TI - [Congenital aplasia of the left half of the pericardium]. PMID- 4335428 TI - [Pre- and post-operative angiography of the coronary arteries following aorto coronary venous by-pass]. PMID- 4335430 TI - [Ventricular septal perforation by selective transseptal angiocardiography]. PMID- 4335431 TI - [Pleural mesotheliomas in dockers]. PMID- 4335432 TI - [Lung scanning with radio-active gases and aerosols]. PMID- 4335433 TI - [Pancreatic scanning using 75 Se-methionin and pancreozymin]. PMID- 4335434 TI - [Radiostrontium scans for plasmacytoma]. PMID- 4335435 TI - [The value of 67 Ga scans for the demonstration and localisation of malignant tumours]. PMID- 4335436 TI - [Radioisotope renography with subtraction of the extraparenchymal radioactivity]. PMID- 4335437 TI - [Nuclear medicine studies in postoperative excretion disorders of transplanted kidneys]. PMID- 4335438 TI - [Value of nuclear medicine functional diagnosis (autofluoroscope) compared with roentgen contrast demonstration of the kidneys (pyelogram, angiogram)]. PMID- 4335439 TI - Posthospital care of the patient past 65. PMID- 4335440 TI - [Occupational diseases of machine-tool operators in the machinery industry]. PMID- 4335441 TI - Properties of adenyl cyclase from human jejunal mucosa during naturally acquired cholera and convalescence. AB - The enterotoxin of Vibrio cholerae causes copious fluid production throughout the lenght of the small intestine. As this is thought to be mediated by stimulation of adenyl cyclase, a study has been made of the activity and properties of this enzyme in jejunal biopsy tissue taken from patients during the diarrheal phase of cholera and after recovery. Adenyl cyclase activity during cholera was increased more than twofold relative to the enzyme in convalescence. Under both conditions stimulation by prostaglandin E(1) (PGE(1)) and by fluoride was observed. The responsiveness to PGE(1) was not altered in cholera; the total activity of the fluoride-stimulated enzyme was similar, a finding that suggests cholera toxin stimulates pre-existing enzyme in the intestinal cell. The enzymes during cholera and convalescence were similar in all other properties examined. Optimal Mg(++) concentration was 10 mM; Mn(++) at 5 mM stimulated the enzyme but could not replace Mg(++) except in the presence of 10 mM fluoride. Calcium was markedly inhibitory at concentrations greater than 10(-4) M. The pH optimum was 7.5 and the Michaelis constant (K(m)) for ATP concentration approximated 10(-4) M. Thus the interaction of cholera toxin with human intestinal adenyl cyclase does not alter the basic properties of the enzyme. When biopsy specimens were maintained intact in oxygenated Ringer's solution at 0 degrees C, no loss of activity was observed at 1(1/2) and 3 hr. In contrast, when the cells were homogenized, rapid loss of activity, with a half-life of 90 min was seen even at 0 degrees C. Consequently for comparative assays of human jejunal adenyl cyclase, strict control of the experimental conditions is required. It was under such conditions that a twofold increase in basal adenyl cyclase activity during cholera was observed. PMID- 4335442 TI - Phenobarbital-induced alterations in vitamin D metabolism. AB - The metabolic fate of intravenously injected vitamin D(3)-1,2-(3)H (D(3)-(3)H) was studied in two normal individuals on chronic phenobarbital therapy. Silicic acid column chromatography of lipid-soluble plasma extracts obtained serially for 96 hr after D(3)-(3)H injection demonstrated a decreased plasma D(3)-(3)H half life and increased conversion to more polar metabolites. The polar metabolites formed included several with chromatographic mobility similar to known biologically inactive vitamin D metabolites and one with chromatographic mobility identical to 25-hydroxycholecalciferol. Disappearance of this latter material was also accelerated. A child with rickets and a normal volunteer studied before and after a 2 wk course of phenobarbital therapy demonstrated similar alterations in D(3)-(3)H metabolism. When liver microsomes from 3-wk-old Sprague-Dawley rats treated with phenobarbital were incubated with D(3)-(3)H, polar metabolites were produced with chromatographic mobility similar to the plasma D(3)-(3)H metabolites from phenobarbital-treated humans. Similar incubations employing 25 hydroxy-cholecalciferol-26-27-(3)H as the substrate also demonstrated an increased conversion to polar metabolites. The data suggest that the reported increased incidence of osteomalacia observed in patients on chronic anticonvulsant therapy may be the result of an accelerated conversion of vitamin D and its active metabolite, 25-hydroxycholecalciferol, to polar metabolites by druginduced liver microsomal enzymes. PMID- 4335443 TI - 25-Hydroxycholecalciferol. A comparative study in deficiency rickets and different types of resistant rickets. AB - The effects of 25-hydroxycholecalciferol were studied in 4 children with deficiency rickets and 22 children with D-resistant rickets, including patients with hereditary hypophosphatemic D-resistant rickets, "pseudo-deficiency" rickets, and rickets secondary to cystinosis or to tyrosinosis. Three protocols were used. (a) 8 days after a single oral dose of 16,000 IU of 25 hydroxycholecalciferol, normalization of all biological parameters was observed in all cases of deficiency rickets. A complete lack of response was observed in the different types of resistant rickets. (b) Under prolonged administration of 2,640 IU/day for 2 months, clinical-biological symptoms and X-ray lesions disappeared, and a catch-up growth pattern was observed in deficiency rickets; no relapse of rickets occurred up to 5 months after therapy was stopped. The same dose had no significant effect in 10 patients with hereditary hypophosphatemic D resistant rickets. A bone biopsy performed in one case showed the persistence of characteristic lesions. (c) With increasing doses of 25-hydroxycholecalciferol varying from 6,000 to 30,000 IU/day and a follow-up of 6 months up to 2 yr duration, clinical-biological-radiologic recovery and catch-up growht was obtained in all cases of "pseudo-deficiency" rickets. In hypophosphatemic hereditary D-resistant rickets, 5 out of 13 patients' serum concentration of phosphorus reached at least 30 mg/liter, but a catch-up growth pattern was not observed. These results indicate that (a) 25-hydroxycholecalciferol is highly active in deficiency rickets; (b) a defect in the conversion of vitamin D(3) to its active 25-hydroxy metabolite is probably not the metabolic defect in any of the different types of vitamin D-resistant rickets studied. PMID- 4335444 TI - Effect of cholera enterotoxin on ion transport across isolated ileal mucosa. AB - The effects of cholera enterotoxin on intestinal ion transport were examined in vitro. Addition of dialyzed filtrate of Vibrio cholerae (crude toxin) to the luminal side of isolated rabbit ileal mucosa caused a delayed and gradually progressive increase in transmural electric potential difference (PD) and shortcircuit current (SCC). A similar pattern was observed upon addition of a highly purified preparation of cholera toxin, although the changes in PD and SCC were smaller. Na and Cl fluxes across the short-circuited mucosa were determined with radioisotopes 3-4 hr after addition of crude toxin or at a comparable time in control tissues. The toxin caused a net secretory flux of Cl and reduced to zero the net absorptive flux of Na. Similar flux changes were observed when either crude or purified toxin was added in vivo and tissues were mounted in vitro 3-4 hr later. Additon of D-glucose to the luminal side of toxin-treated mucosa produced a large net absorptive flux of Na without altering the net Cl and residual ion fluxes. Adenosine 3',5'-cyclic phosphate (cyclic AMP) and theophylline had previously been shown to cause a rapid increase in SCC and ion flux changes similar to those induced by cholera toxin. Pretreatment of ileal mucosa with either crude or purified cholera toxin greatly reduced the SCC response to theophylline and dibutyryl cyclic AMP, which, together with the flux data, suggest that both cyclic AMP and cholera toxin stimulate active secretion by a common pathway. Inhibition of the SCC response to theophylline was observed after luminal but not after serosal addition of toxin. In vitro effects of cholera toxin correlated closely with in vivo effects: heating toxin destroyed both; two V. cholerae filtrates which were inactive in vivo proved also to be inactive in vitro; PD and volume flow measurements in isolated, in vivo ileal loops of rabbit revealed that the PD pattern after addition of toxin is similar to that seen in vitro and also correlates closely with changes in fluid movement. The results suggest that stimulation by cholera toxin of a cyclic AMP-dependent active secretory process of the intestinal epithelial cells is a major cause of fluid loss in cholera. PMID- 4335445 TI - Effects of dibutyryl cyclic adenosine 3',5'-monophosphate and parathyroid extract on calcium and phosphorus metabolism in hypoparathyroidism and pseudohypoparathyroidism. AB - It has been proposed previously that the metabolic defect in pseudohypoparathyroidism which accounts for parathyroid hormone unresponsiveness is an absence or abnormal form of the adenyl cyclase system in kidney and presumably in bone. To determine whether there is an associated defect in the response mechanism to cyclic adenosine 3',5'-monophosphate (cyclic AMP), the effects of parathyroid extract (PTE), and dibutyryl cyclic AMP were compared in patients with either surgical hypoparathyroidism or pseudohypoparathyroidism. PTE and dibutyryl cyclic AMP both increased serum and urinary calcium, lowered the serum phosphorus, and increased urinary phosphorus in patients with hypoparathyroidism. PTE also increased urinary cyclic AMP in these patients. PTE increased serum and urinary calcium and urinary phosphorus but did not alter serum phosphorus or urinary cyclic AMP in the patients with pseudohypoparathyroidism. Dibutyryl cyclic AMP increased the serum and urinary calcium, lowered the serum phosphorus, and increased urinary phosphorus in all the patients with pseudohypoparathyroidism. The results indicate that (a) dibutyryl cyclic AMP can reproduce the effects of parathyroid hormone on calcium and phosphorus metabolism in man, (b) the response mechanism to cyclic AMP appears to be intact in pseudohypoparathyroidism, and (c) PTE apparently produces some of its characteristic effects on calcium and phosphorus metabolism in pseudohypoparathyroidism in the absence of an increase in urinary cyclic AMP. PMID- 4335447 TI - Effects of catecholamines and their interaction with other hormones on cyclic 3',5'-adenosine monophosphate of the kidney. AB - Catecholamines have several physiological effects on the kidney. These include: (a) stimulation of renin synthesis in the cortex: (b) antidiuresis by beta adrenergic agents; and (c) diuresis by alpha adrenergic stimulation. The role of cyclic 3',5'-adenosine monophosphate (cyclic AMP) in the renal actions of catecholamines was evaluated by measuring the effects of several adrenergic agents on cyclic AMP concentration in the dog kidney. Beta adrenergic activity increased cyclic AMP concentration in the renal cortex, a finding consistent with the hypothesis that beta-adrenergic stimulation augments renin synthesis by increasing cyclic AMP generation. Beta adrenergic stimulation, like vasopressin, increased cyclic AMP concentration in the renal medulla. This suggests that beta adrenergic stimulation causes antidiuresis by augmenting cyclic AMP generation in the renal medulla. Alpha adrenergic activity inhibited the effect of vasopressin to stimulate cyclic AMP generation. These results support the hypothesis that the diuretic effect of alpha adrenergic stimulation is mediated by inhibition of the effect of vasopressin to increase cyclic AMP generation. PMID- 4335446 TI - Effect of magnesium depletion on responsiveness to parathyroid hormone in parathyroidectomized rats. AB - Hypocalcemia and resistance to exogenous parathyroid hormone have been reported in several clinical states associated with magnesium deficiency. On the basis of such observations, it has been suggested that magnesium depletion per se may result in impaired responsiveness of the adenyl cyclase-adenosine 3',5' monophosphate (3',5'-AMP) system. To test this hypothesis, 4 wk old male parathyroidectomized rats were maintained on normal or magnesium-deficient diets for 4 wk and their responses to parathyroid hormone compared. Serum magnesium and calcium fell progressively in the magnesium-deficient group. Despite clinical and biochemical evidence of severe magnesium deficiency in these animals, renal production and excretion of 3',5'-AMP in response to parathyroid hormone was normal both in vitro and in vivo. Additionally, administration of either dibutyryl 3',5'-AMP or parathyroid extract to fasting magnesium-depleted rats produced a normal increase in serum calcium. Parathyroid hormone infusion studies demonstrated normal renal and skeletal responsiveness as measured by urinary excretion of calcium, magnesium, phosphate, and hydroxyproline. These data show that the effect of parathyroid hormone on 3',5'-AMP formation and excretion, the responsiveness of skeletal tissue to 3',5'-AMP, and the renal and skeletal system responses to parathyroid hormone are not altered by pure magnesium deficiency in the parathyroidectomized rat. PMID- 4335448 TI - Antibiotics for Pseudomonas aeruginosa sepis: inadequate proof of efficacy. PMID- 4335449 TI - Induction, course, and transmissibility of monkeypox in the baboon (Papio cynocephalus). PMID- 4335450 TI - Antibodies to early antigens induced by Epstein-Barr virus in infectious mononucleosis. PMID- 4335451 TI - Functional characteristics of human toxic neutrophils. PMID- 4335452 TI - Properties of a virus isolated from patients with MS-1 infectious hepatitis. PMID- 4335453 TI - Neurotropic properties of measles virus in hamsters and mice. PMID- 4335454 TI - Viral infections and diseases of the endocrine system. PMID- 4335455 TI - Swelling of mitochondria from rabbit liver induced by staphylococcal enterotoxin B. PMID- 4335456 TI - Bacteriologic and epidemiologic characteristics of Enterobacter hafniae and Enterobacter liquefaciens. PMID- 4335457 TI - Binding of polymyxin antibiotics to tissues: the major determinant of distribution and persistence in the body. PMID- 4335458 TI - Differentiated nephroblastoma: solid, cystic or mixed. PMID- 4335459 TI - Effect of polishing agents on root roughness. PMID- 4335460 TI - Heroin addicts: patterns of behavior during detoxification. PMID- 4335461 TI - Domain conflicts in a children's psychiatric hospital. PMID- 4335462 TI - Dissociation and play therapy: a case study. PMID- 4335464 TI - The skin game. PMID- 4335463 TI - Micro-communications. PMID- 4335465 TI - Distinguished panel of psychiatrists recommends appointment of an advocate to represent mental health needs of the elderly. PMID- 4335466 TI - Effects of sensory stimulation and remotivation on schizophrenic persons. PMID- 4335467 TI - Restraining the violent patient. PMID- 4335468 TI - Replacement of the intrathoracic trachea and both stem bronchi with a molded Silastic prosthesis. PMID- 4335470 TI - Deprivation of paradoxical sleep and in vitro cerebral protein synthesis in the rat. PMID- 4335469 TI - Embryopathic effects of mercuric salts. PMID- 4335471 TI - Observations on H 10 ZE mixed tumor. PMID- 4335473 TI - Ultrastructural cytopathology of human cerebral gliomas. PMID- 4335472 TI - Calcium metabolism in tumors, its relationship with chromium complex accumulation. IV. 51 Cr-alloxantin incorporation and calcium-phosphorus composition. PMID- 4335474 TI - [Application of the method of 2-dimensional echospondylography for determining landmarks in lumbar punctures]. PMID- 4335475 TI - Pyrophosphate synovitis. PMID- 4335476 TI - Neurobiological significance of cyclic 3',5'-adenosine monophosphate. PMID- 4335477 TI - Spectrophotometric determination of micro amounts of perchlorate in biological fluids. PMID- 4335478 TI - Bovine hepatic fructose 1,6-diphosphatase: purification and properties. PMID- 4335479 TI - Modification of hepatic fructose 1,6-diphosphatase activity by proteolytic enzymes and sulfhydryl reagents. PMID- 4335480 TI - Bovine hepatic fructose 1,6-diphosphatase: -glycerophosphate hydrolysis-evidence for a shared active site. PMID- 4335481 TI - Modification of the catalytic properties of rabbit liver fructose diphosphatase by a particulate fraction from liver. PMID- 4335482 TI - Fructose 1, 6-diphosphatase from liver: isolation of the native form with optimal activity at neutral pH. PMID- 4335483 TI - Pyruvate: ferredoxin oxidoreductase. II. Characteristics of the forward and reverse reactions and properties of the enzyme. PMID- 4335484 TI - Metabolic control mechanisms in human erythrocytes. The role of glyceraldehyde phosphate dehydrogenase. PMID- 4335485 TI - The phosphorylation of yeast phosphoglycerate mutase. PMID- 4335486 TI - The role of molybdenum in terminal DPNH oxidation in beef heart. PMID- 4335487 TI - Isolation of some properties of a succinylated protein-lipid complex derived from calf brain myelin. PMID- 4335488 TI - Inhibition of yeast inorganic pyrophosphatase by nucleotidylsulfates. PMID- 4335489 TI - [Demonstration of viruses in the area of water hygiene. I. The significance of virus occurrence and the problem of detecting and evaluating small quantities of virus]. PMID- 4335490 TI - [Inactivation of viruses by sewage protozoa]. PMID- 4335491 TI - Thermography in the diagnosis of breast cancer. PMID- 4335492 TI - [Histochemical, electronmicroscopical and autoradiographical studies on experimentally induced nephroblastomas]. PMID- 4335493 TI - Apparent increases in tumour NAD + levels induced by treatment with vitamin K 1 or its synthetic substitutes. PMID- 4335494 TI - FBJ virus-induced tumours in mice. A histopathological study of FBJ virus tumours and their relevance to murine and human osteosarcoma arising in bone. AB - Nine of the 15 neonatal CBA mice injected intramuscularly with a Moloney concentrate containing FBJ virus developed tumours: likewise 5 of 7 CBA neonates injected intraperitoneally with a cell-free filtrate derived from a transplanted tumour of the former group.Of soft tissue origin, these FBJ sarcomata have a characteristic histological appearance and are of low grade malignancy. Although occasional islets of cartilage osteoid and bone were noted, these were regarded as indicative of evolutionary metaplasia in the collagenous matrix of pleomorphic fibroblastic sarcoma. No tumour was acceptable as osteosarcoma of conventional type and osseous origin. There were, however, additionally 2 minute spindle cell sarcomata arising in femoral periosteum and non-neoplastic periosteal proliferation was observed. The differences of these FBJ fibroblastic sarcomata from murine osteosarcoma-either spontaneous or induced by Sr 90-are emphasized. Furthermore, their deviation from the structural pattern and behaviour of human osteosarcoma is discussed. PMID- 4335495 TI - Morphology of tumours induced in hamsters by CELO virus, tumour tissue, and tumour cells grown in culture. AB - Tumours in hamsters, induced by the chicken-embryo-lethal-orphan (CELO) virus, by tumour tissue transplants, or by tumour cells grown in culture, were well circumscribed solid tumours and covered by a thin capsule-like structure. All were fibrosarcomata. However, tumours produced by the 3 inocula exhibited the following histological differences. Neoplasms induced by CELO virus were generally less differentiated and were composed of cells with polygonal or oval nuclei and indistinct cytoplasmic boundaries. Numerous multinucleated bizarre giant cells were found. Those produced by tumour tissue transplants were more differentiated and were composed of spindle shaped cells with abundant collagen fibre formation. Neoplasms induced by tumour cells grown in culture were generally undifferentiated with many mitotic figures and contained numerous giant cells.Cells from tumours induced by CELO virus or tumour transplants produced similar morphologies when cultured in vitro. The cell cultures consisted of large cells with oval or rounded large nuclei and prominent nucleoli. Multinucleated giant cells, cells in mitosis, and a disorganized growth pattern were also characteristic of the cell cultures. However, mitosis and a piling-up of cells occurred more frequently with cell cultures derived from the CELO virus-induced tumour. PMID- 4335497 TI - Diagnostics of Entamoeba histolytica by means of cultures on solid media. PMID- 4335496 TI - Cultures from adult rat liver cells. II. Demonstration of organ-specific cell surface antigens on cultured cells from normal liver. AB - The occurrence of organ-specific antigens on the surface of cells freshly isolated from normal adult rat liver and from liver cell lines cultured as monolayers for up to 6 months is demonstrated. Enzyme treatment used to disaggregate parenchymal cells from liver tissue did not result in appreciable changes in the antigen profile of the cell surface membrane. PMID- 4335498 TI - Unusual dermatoglyphic findings associated with cytomegalic inclusion disease of infancy. A first report and practical review. AB - Infection with the human cytomegalovirus has a teratogenic effect on the fetus during the first trimester of gestation as does rubella. Since unusual dermatoglyphic findings have been observed in infants with congenital rubella infection, the present study was designed to determine whether or not unusual dermatoglyphics occur in patients with cytomegalic inclusion disease of infancy. Analysis of dermatoglyphics in 15 infants with cytomegalic inclusion disease revealed unusual features in all infants. These features are reported here for the first time and are compared with dermatoglyphic findings in a normal population as well as with those of available parents of the infants. PMID- 4335500 TI - Ultrastructural study of nucleolar alterations produced by a single carcinogenic dose of urethan in mouse hepatocytes. PMID- 4335499 TI - Ultrastructural studies and metabolic regulation of isolated adrenocortical carcinoma cells of rat. PMID- 4335501 TI - Multiple forms of deoxythymidine kinase in various tissues. PMID- 4335502 TI - Tumorigenesis studies with 1,2-dimethylhydrazine dihydrochloride, hydrazine sulfate, and isonicotinic acid in golden hamsters. PMID- 4335503 TI - A difference in the architecture of surface membrane between two cell types of rat ascites hepatomas. PMID- 4335504 TI - A comparative study of cellular organelles of Morris hepatomas. PMID- 4335506 TI - Digital nerve compression secondary to palmar aneurysm. PMID- 4335505 TI - Dupuytren's contracture: some associated biophysical abnormalities. PMID- 4335507 TI - Phalangeal sarcomas simulating infections of the digits. Review of the literature and report of four cases. PMID- 4335508 TI - Ulnar nerve compression due to an anomalous muscle in the canal of Guyon. PMID- 4335509 TI - [Use of lipoiodine-triotrast emulsion in experimental bronchography]. PMID- 4335510 TI - [Morbidity and health status of crews and shore personnel of the transit river fleet of the Ukraine SSR]. PMID- 4335511 TI - Accident dosimetry by the use of thermo-luminescent characteristics of environmental substances. PMID- 4335512 TI - [Electron microscopic observations on the development of Yaba monkey tumor poxvirus in primates]. PMID- 4335513 TI - [Effects of various hormones on 5 -3 -hydroxysteroid dehydrogenase activities in the normal, ovariectomized and hypophysectomized rats]. PMID- 4335514 TI - [Dynamic test for evaluation of fetoplacental function--flucturation of urinary estrogen level due to administration of synthetic ACTH-Z (Cortrosyn Z)]. PMID- 4335515 TI - Protein kinase activity in equine herpesvirus. AB - A protein kinase which is intimately associated with equine herpesvirus (equine abortion virus) was found by using adenosine triphosphate-gamma-(32)P as a phosphate donor and virus protein as an acceptor. Consistent demonstration of the activity requires prior removal of phosphohydrolase. The kinase activity requires Mg(2+), is not stimulated by cyclic adenosine monophosphate, but is enhanced by added protamine or arginine-rich histone. The labeled product is resistant to ribonuclease, deoxyribonuclease, and chloroform-methanol but is sensitive to Pronase. Other tests suggest that serine and threonine residues are the acceptor sites. In the in vitro reaction, the incorporation represents an average of approximately 4,500 phosphate residues per virion, and all 17 virus protein bands resolved by polyacrylamide gel electrophoresis appear to be labeled. PMID- 4335516 TI - Cell-dependent differences in the production of infectious herpes simplex virus at a supraoptimal temperature. AB - The replication of herpes simplex virus (HSV) was compared in rabbit and hamster cells at optimal and supraoptimal temperatures. Replication occurred in cells of either species at 33 C, but the total infectious virus yield was routinely about 10-fold greater in rabbit cells than in hamster cells. At 39 C, this difference was exaggerated to greater than 100,000-fold. Whereas infectious virus was produced and plaques formed in rabbit kidney cell monolayers at the higher temperature, neither developed in those derived from hamster embryos. Elevating the temperature from 33 C to 39 C at various time intervals after exposure of the cultures to virus revealed that production of infectious virus in hamster cells was completely heat-sensitive up to 6 hr after infection. Specific viral antigens and viral deoxyribonucleic acid (DNA) were synthesized in both rabbit and hamster cell cultures. In addition, cellular DNA synthesis was depressed and cytopathic effects occurred in both cell systems. These cytopathic effects were not observed in cell cultures treated with HSV previously inactivated with ultraviolet light. Compared with parallel cultures at 33 C, the amount of viral DNA synthesized at 39 C was greatly reduced in both systems. In hamster cells, the reduction was twofold greater than in rabbit cells. This cell-dependent thermal inhibition of HSV replication in hamster cells did not occur with vaccinia virus. PMID- 4335517 TI - Transfer ribonucleic acid synthetase activity associated with avian myeloblastosis virus. AB - Avian myeloblastosis virions purified by conventional techniques were shown to be associated with or to contain transfer ribonucleic acid synthetase activity. Arginine, tryptophan, cystine, and lysine synthetase activities were observed. PMID- 4335518 TI - Inhibition of virus growth by ouabain: effect of ouabain on the growth of HVJ in chick embryo cells. AB - The effect of ouabain (g-strophanthin), a cardiac glycoside, on the growth of several enveloped viruses was examined. It was found that the growth of HVJ (Sendai virus) in chick embryo cells was markedly inhibited by the drug at a concentration as low as 5 x 10(-5)m. A virus-inhibitory concentration of ouabain did not cause morphological changes in uninfected cells, nor did it have the capacity to inactivate virus infectivity. Ouabain interfered with the intracellular synthesis of viral macromolecules. Although viral ribonucleic acid and viral antigens were synthesized by the ouabain-treated cells, the rate of synthesis was slower, and the total amounts of these macromolecules were smaller than those in the untreated control cells. It is suggested that ouabain inhibits the function of membrane-bound Na, K-adenosine triphosphatase of the chick embryo cells and thus prevents accumulation of K ion in them. Accumulation of intracellular K ion to a certain level would be needed for events of exponential growth of virus to proceed, and ouabain might inhibit this step by preventing such accumulation of K ion. This view was supported by the finding that the concentration of K ion in the HVJ-infected cells was rapidly reduced by the treatment with ouabain, and that, when the ouabain-treated culture was shifted to a medium containing a higher concentration of K ion than normal medium, virus production started in parallel with the increase of intracellular K ion. The fact that the concentration of K ion in BHK-21 cells, which support virus growth in the presence of ouabain, is not reduced by the treatment with the drug also suggested this possibility. PMID- 4335519 TI - Detection and assay of avian tumor virus group-specific antigen and antibody by the paired radioiodine-labeled antibody technique. AB - The paired radioiodine-labeled antibody technique (PRILAT) was applied to the detection and quantitation of avian tumor virus group-specific (gs) antigens and antibody. The technique proved to be specific, repeatable, and appreciably more sensitive than the microcomplement-fixation test for avian leukosis (COFAL). The PRILAT facilitated direct measurement of comparative antigen content of several types of transformed, neoplastic, or virus-infected cells and the magnitude of nonspecific antibody binding by appropriate control cells. The versatility of the technique was illustrated by application to the detection and quantitation of gs antibody content of chicken, turkey, pigeon, and hamster sera. Antibodies were detected in COFAL-negative sera from hamsters bearing tumors induced by the Schmidt-Ruppin strain of Rous sarcoma virus. Sera from chickens bearing similar tumors were not positive for gs antibodies, although sera from turkeys and chickens immunized with avian leukosis virus did contain gs antibodies. PMID- 4335520 TI - Acquisition of sequences homologous to host deoxyribonucleic acid by closed circular simian virus 40 deoxyribonucleic acid. AB - The synthesis of closed circular simian virus 40 (SV40) deoxyribonucleic acid (DNA) containing sequences homologous to host cell DNA depends upon the conditions under which the cells are infected. When BS-C-1 monkey cells were infected with non-plaque-purified virus at low multiplicity of infection [MOI, 0.032 plaque-forming units (PFU)/cell], little, if any, of the SV40 DNA extracted from the infected cells hybridized to host DNA; but when increasingly higher multiplicities were used (in the range 0.16 to 3,000 PFU/cell), an increasingly greater amount of the extracted SV40 DNA hybridized to host DNA. The same effect was observed when the closed circular SV40 DNA was extracted from purified virions (grown at low and high MOI) rather than from the infected cell complex. When the cells were infected at high MOI with plaque-purified virus (11 viral clones were tested), none of the SV40 DNA extracted from the cells hybridized detectably with host cell DNA. However, plaque-purified virus that was serially passaged, undiluted, induced the synthesis of virus DNA which again showed extensive homology to host DNA. It is suggested that, under certain circumstances, recombination occurs between viral and host DNA during lytic infection which results in the incorporation of host DNA sequences into closed circular SV40 DNA. PMID- 4335522 TI - Viruses of Entamoeba histolytica. I. Identification of transmissible virus-like agents. AB - This and a companion report deal with the identification and morphogenesis of viruses in axenized cultures of Entamoeba histolytica. There are probably two different types of virus each producing a different pathological picture in different amoebal strains, or, less likely, there is one type of agent having widely different morphological and morphogenetical pictures in different strains of E. histolytica. Both types of agent produce a lytic response in axenized amoebae and have been serially passaged to an extent assuring their replicating nature. One appears to replicate in the nucleus as multiple clusters of fine filaments which ultimately lyse the nucleus, causing cell death. The second type of agent appears to be a typical polyhedral virus, seen only in the cytoplasm and also resulting in lysis of the cell. A particle morphologically indistinguishable from this second agent is also found in late passages of the agent producing the nuclear pathology. PMID- 4335521 TI - Sequence heterogeneity in closed simian virus 40 deoxyribonucleic acid. AB - The heteroduplex molecules formed by self-annealing of denatured, singly nicked simian virus 40 (SV40) deoxyribonucleic acid (DNA) prepared from closed viral DNA were examined by formamide-protein film electron microscopy to test the DNA for sequence homogeneity. Sequence inhomogeneity appears in the heteroduplexes as single-strand loops. These result from sequence deletion or from sequence substitution, if regions greater than 50 nucleotides are involved. The undenatured DNA from viruses passaged twice at multiplicities of infection much less than 1 plaque-forming unit (PFU) per cell appeared to be homogeneous in size. The heteroduplexes formed by this DNA indicated that approximately 2% of the molecules carried deletions, but that substitutions were below the level of detection. In contrast, undenatured DNA from viruses grown by passaging undiluted lysates seven times or by infection with stock virus at a multiplicity of infection of 5 PFU per cell contained a large frequency of molecules shorter than the full length. The heteroduplex samples indicated that 12 and 7% of the undenatured material contained base substitutions, and 13 and 11% contained deletions. The deletions and substitutions appear to occur in separate molecules. Length measurements on heteroduplexes displaying the loop characteristic of substitutions have established that these molecules are from true sequence substitutions, and not from adjacent or overlapping deletions. More than 80% of the molecules carrying substitutions are shorter than the native SV40 length. On the average, the substituted sequence is about 20% of the length of SV40, but it replaces a sequence about 30% of the native length. The substituted sequences may be host cell nuclear DNA, possibly arising from integration of SV40 into the chromosome followed by excision of the SV40 DNA together with chromosomal DNA. PMID- 4335523 TI - Viruses of Entamoeba histolytica. II. Morphogenesis of the polyhedral particle (ABRM 2 leads to HK-9) leads to HB-301 and the filamentous agent (ABRM) 2 leads to HK-9. AB - The intracellular development of two morphologically different amoebal viruses has been studied by electron microscopy. One is a polyhedral agent which was observed as early as 24 hr after infection in the perinuclear cytoplasm. Subsequently, cell lysis occurred and particles were found in large number bound to membranes of disrupted amoebae. Other particles were found in phagocytic vacuoles suggesting a possible portal of entry into amoebae. The other virus is a filamentous particle which is first seen in small clusters in the nucleus after 24 hr of infection. The number of particles increases such that by 72 hr massive whorls of particles occupy a substantial part of the nucleus. After rupture of the nuclear membrane, clusters of filaments are widely dispersed throughout the cytoplasm. Still later, the cytoplasmic membrane disintegrates and clusters of filaments are found extracellularly, but free of cell membranes. The morphology of these agents is discussed in comparison with a variety of plant, animal, and bacterial viruses. PMID- 4335524 TI - Chromatographic separation and antigenic analysis of proteins of the oncornaviruses. II. Mammalian leukemia-sarcoma viruses. AB - Proteins of leukemia and sarcoma viruses from the chicken, mouse, hamster, and cat were analyzed by gel filtration in guanidine hydrochloride. The mammalian viruses were found to contain six major proteins, whereas the avian viruses contained seven proteins. Proteins of viruses from different mammalian species had the same molecular weights which also closely resembled the molecular weights of the six equivalent avian viral proteins. These results defined a basic similarity in protein composition for the C-type viruses of avian and mammalian origin. The two glyco-proteins of murine leukemia virus were identified immunologically as constituents of the viral membrane. Antisera prepared against other proteins distinguished individual internal viral antigens in immunodiffusion tests and also reacted in immunofluorescence with cytoplasmic components of infected cells. Antisera which reacted with the major internal viral proteins did not contain antibodies inhibitory to the viral reverse transcriptase. PMID- 4335526 TI - Suppressed renin response in unilaterally nephrectomized subjects. PMID- 4335525 TI - Relationship between organization of mammary tumors and the ability of tumor cells to replicate mammary tumor virus and to recognize growth-inhibitory contact signals in vitro. AB - Mammary tumor virus (MTV) replication was confined primarily to cells organized as acini in intact mouse mammary glands. Primary mammary tumors maintained a high degree of acinar organization and cells therein continued to replicate MTV vegetatively. Nonacinar mammary cells, derived by serial transplantation of acinar tumor cells, no longer actively replicated MTV. This suggests that phenotypic differences exist among mammary epithelial cells in their ability to support virus replication, that a fundamental relationship exists between the organization of epithelium for secretion and active virus replication, and that this relationship is not altered as a primary consequence of neoplastic transformation. Mammary epithelial cells from pregnant, non-tumor-bearing, MTV infected BALB/cfC3H mice or from acinar mammary tumors from a number of mouse strains were grown in primary monolayer cultures. Such cell cultures under the influence of insulin and cortisol exhibited the ability to organize into discrete three-dimensional structures called "domes." MTV replication in such cultures took place primarily in cells within the organized domes. Cells cultured from nonacinar tumors did not exhibit any propensity to organize into domes, nor did they replicate MTV in primary culture. This suggests that the cell organizational requirement for MTV replication observed in vivo is conserved in primary culture. Dome formation is not an effect of virus replication, as cells from uninfected BALB/c animals organized into domes in culture without concomitant MTV replication. Growth-regulating signals, exerted between contiguous cells in cultures of non-MTV-infected mammary epithelium, were not modified by the occurrence of active virus replication nor as a direct consequence of neoplastic transformation. Cells derived from nontumor BALB/cfC3H glands and from spontaneous tumors exhibited cell growth kinetics, saturation densities, and deoxyribonucleic acid synthesis kinetics nearly identical to those of noninfected normal mammary epithelium in primary culture. Cell to cell growth regulatory signals were modified in cultures of nonalveolar tumor cells wherein evidence of overgrowth is documented. PMID- 4335529 TI - [Review of the literatures on the optic nerve, 1970]. PMID- 4335530 TI - Purification of hog renin. Properties of purified hog renin. PMID- 4335528 TI - [Comparative studies on the effects of dopamine and orciprenaline in healthy subjects: muscle blood flow, kidney blood flow, kidney function]. PMID- 4335531 TI - [Ultrafine localization of the ATPase activity of plasma membrane cells in mice hepatomas]. PMID- 4335533 TI - [Ovariectomy in breast neoplasms]. PMID- 4335532 TI - [Induction of liver neoplasms by nitrosamines in aquarium fish Lebistes reticulatus (guppi)]. PMID- 4335534 TI - [Comparative studies on mammary tumor virus detection in murine mammae cancer of strain CBA-Bln]. PMID- 4335527 TI - [Hepatitis-associated antigen: clinical and immunological significance]. PMID- 4335535 TI - [Invitro action of nerve and tumor tissue in combined cultivation]. PMID- 4335537 TI - Uptake of calcium ions and the beta-adrenergic receptor site in cardiac muscle. PMID- 4335538 TI - Inhibition kinetics of D-glyceraldehyde 3-phosphate dehydrogenase. PMID- 4335536 TI - Rat liver alcohol dehydrogenase. Purification and properties. AB - Alcohol dehydrogenase (EC 1.1.1.1) from the rat liver supernatant fraction has been purified 200-fold and partially characterized. The isolation procedure involved ammonium sulphate fractionation, DEAE-Sephadex chromatography and gel filtration. The purified enzyme behaved as a homogeneous preparation as evaluated by cellulose acetate and polyacrylamide-gel disc electrophoresis. Sulphoethyl Sephadex chromatography and immunoelectrophoresis with rabbit antiserum indicated the presence of a minor component. Rat liver alcohol dehydrogenase appears to contain 4mol of zinc/mol, has an estimated molecular weight of 65000 and consists of two subunits of similar molecular weight. Heavy-metal ions, thiol-blocking reagents, urea at concentrations below 8m, low pH (5.5) and chelating agents deactivate the enzyme but do not dissociate it into subunits. Deactivated enzyme could not be reactivated. The enzyme is strictly specific for NAD(+) and has a broad specificity for alcohols, which are bound at a hydrophobic site. Inhibition occurred with the enzyme equilibrated with Zn(2+) at concentrations above 0.1mm. PMID- 4335539 TI - 2-Hydroxyglutarate in crustaceans. PMID- 4335540 TI - Development of the squalene-synthesizing system during early stages of pea seed germination. PMID- 4335541 TI - A method for deriving kinetic constants for two enzymes acting on the same substrate. PMID- 4335542 TI - Comparative metabolism of nicotinamide and nicotinic acid in mice. PMID- 4335543 TI - Proton hyperfine splitting in the ESR spectra of a stable hydroxynitroxide and its esters. Application to an ESR assay procedure for alkaline phosphatase. PMID- 4335544 TI - [Hyperfine structure of the ESR spectrum of semidehydro-L(+)-ascorbic acid]. PMID- 4335545 TI - The effect of mannoheptulose on glucose- and pyruvate-stimulated oxygen uptake in normal mouse pancreatic islets. PMID- 4335546 TI - Epidermal structural proteins. I. Isolation and purification of keratohyalin granules of the newborn rat. PMID- 4335547 TI - Dynamic interaction of prostaglandin and norepinephrine in the formation of adenosine 3',5'-monophosphate in human and rabbit platelets. PMID- 4335548 TI - Kinetics of DNA synthesis in immature rat uterus: age dependence and estradiol stimulation. PMID- 4335549 TI - The effects of diphosphonates on the exchangeable and non-exchangeable calcium and phosphate of hydroxyapatite. PMID- 4335550 TI - Immediate complete dentures. PMID- 4335552 TI - Effect of amphetamine on the transmission of repetitive impulses through the isolated superior cervical ganglion of the rat. AB - 1. The cervical sympathetic trunk of the isolated rat superior cervical ganglion was stimulated with short bursts of repetitive pulses. At room temperature with rates of stimulation of 4 Hz and above, the ganglionic action potentials were reduced in size.2. Amphetamine (2.7 x 10(-5)M), which caused some depression of transmission during stimulation at 0.1 Hz, caused a partial reversal of the depression of transmission occurring with rates of stimulation above 4 Hz.3. This action of amphetamine was mimicked by adrenaline (3 x 10(-5)M) and noradrenaline (9.6 x 10(-5)M) but not by isoprenaline (1.8 x 10(-5)M) and was unaffected by propranolol (1.4 x 10(-5)M) but was abolished by prior application of phenoxybenzamine (5.8 x 10(-6)M). Furthermore, this action of amphetamine was unaltered in ganglia taken from rats pretreated with reserpine (single dose of 6 mg/kg, 16 h before dissection).4. Amphetamine had no effect on the surface potentials of the ganglion or on changes in these potentials produced by concentrations of carbachol (5. x 10(-6)M to 5.5 x 10(-3)M).5. It is concluded that amphetamine has a direct action on alpha-adrenoceptors situated at presynaptic sites. PMID- 4335551 TI - Responses of the isolated, perfused human spleen to sympathetic nerve stimulation, catecholamines and polypeptides. AB - 1. The responses of the smooth muscle of the capsule and blood vessels of the isolated, perfused human spleen to sympathetic nerve stimulation, adrenaline, noradrenaline, angiotensin, oxytocin, vasopressin, isoprenaline and acetylcholine have been investigated and compared with those of dog spleen.2. Stimulation of the postganglionic sympathetic nerves to the human spleen at frequencies of 3-10 Hz evoked graded vasoconstriction but very small changes in spleen volume.3. The injection of adrenaline and noradrenaline in doses of 0.25-25 mug to the human spleen produced graded increases in splenic vascular resistance with very small decreases in spleen volume.4. Administration of the alpha-adrenoceptor blocking drug phenoxybenzamine completely abolished or considerably reduced the vascular responses of the human spleen to sympathetic nerve stimulation or the injection of noradrenaline.5. The vascular action of adrenaline was often reversed to elicit a vasodilatation after phenoxybenzamine suggesting the presence of beta adrenoceptors in the vascular bed. This was confirmed by the administration of isoprenaline which induced a marked reduction in vascular resistance of the human spleen.6. The polypeptides angiotensin and vasopressin induced a marked vasoconstriction in the human spleen without changes in the spleen volume. These effects were uninfluenced by the administration of phenoxybenzamine.7. The polypeptide oxytocin caused a slight vasodilatation in the human spleen, an effect almost exactly mimicked by the preservative chlorobutanol.8. Preliminary experiments suggest that noradrenaline is the transmitter released by the postganglionic nerves to the human spleen.9. These results provide direct evidence that the normal human spleen, unlike that of the dog, does not have a reservoir function. It is suggested that contractions of the enlarged human spleen may occur in various pathological conditions. PMID- 4335553 TI - [Extensive extra-cranial metastases of glioblastoma multiforme--a case report and clinicopathological observation on the cases in the literature]. PMID- 4335554 TI - Suppression of antibody response in congenital rubella. PMID- 4335555 TI - Adrenocorticotropic hormone unresponsiveness: report of a girl with excessive growth and review of 16 reported cases. PMID- 4335556 TI - Mutations induced in Haemophilus influenzae by transformation with nitrosoguanidine-treated DNA. PMID- 4335557 TI - The use of steroids in the treatment of rheumatic diseases. PMID- 4335558 TI - [Foot-and-mouth disease in man]. PMID- 4335559 TI - [Wilm's tumors, neuroblastomas and bone neoplasms in childhood]. PMID- 4335560 TI - New possibilities of analysis in electronystagmography. PMID- 4335561 TI - The time-histogram as a way to evaluate the transition function of the vestibular system. PMID- 4335562 TI - [Activity of the Krebs cycle dehydrogenases, phosphatases and tryptophan pyrrolase in tissues of piglets treated with tetracycline]. PMID- 4335563 TI - [Effect of mechanical low-frequency vibrations on the activity of phosphatases in the regenerating liver of white rat]. PMID- 4335564 TI - Effect of nerve stimulation in vitro on the noradrenaline content of the rat vas deferens in the presence of inhibitors of noradrenaline uptake and syntheses. PMID- 4335565 TI - Determination of crown-rump length from fetal long bones: humerus and femur. PMID- 4335566 TI - Adenovirus type 8 infections in the United States. IV. Observations on the pathogenesis of lesions in severe eye disease. PMID- 4335567 TI - Cataracts acquired following varicella infection. PMID- 4335568 TI - Optic nerve sarcoidosis. Report of a case. PMID- 4335569 TI - Acetylcholine and the cyclic AMP system in smooth muscle. PMID- 4335570 TI - Studies on the inhibition of amino acid incorporation into protein by isolated rat liver ribosomes by protein kinase. PMID- 4335572 TI - The action of phospholipase C on black film bilayer membranes. PMID- 4335571 TI - Role of mitochondria in calcification, Mitochondrial activity distribution in the epiphyseal plate and accumulation of calcium and phosphate ions by chondrocyte mitochondria. PMID- 4335573 TI - A case of non-chromaffin paraganglioma presenting in pregnancy as a dumb-bell tumour. PMID- 4335574 TI - Hypoadrenalism. PMID- 4335575 TI - Paget's disease of the skin. PMID- 4335576 TI - Effect of adaptation to swimming on the metabolic changes in rat liver & kidney. PMID- 4335577 TI - Purification of ribonuclease U 1 and some properties of ribonucleases U 1 and N 1 . PMID- 4335578 TI - Virucidal activity of chlorhexidine on strains of Herpesvirus hominis, poliovirus, and adenovirus. AB - The infectivity titre of two strains of Herpesvirus hominis was reduced by not more than six log(10) units by 90 minutes' exposure to chlorhexidine at a final concentration of 0.02% at room temperature. Under identical conditions the compound was ineffective against a vaccine strain of poliovirus and against an adenovirus. Experimental conditions are described whereby the toxic effect of the disinfectant on the tissue culture assay systems are minimized. PMID- 4335579 TI - Ultrastructural changes in the adenohypophysis of metyrapone-treated rabbits. PMID- 4335580 TI - A biochemical comparison of the lactogenic effect of prolactin and growth hormone on mouse mammary gland in organ culture. PMID- 4335581 TI - The walls of Mycobacterium lepraemurium: chemistry and ultrastructure. PMID- 4335582 TI - A comparison of respiratory processes in Spirillum volutans, Spirillum itersonii and Spirillum serpens. PMID- 4335583 TI - Mechanism of DNA chain growth. Vii. Direction and rate of growth of T4 nascent short DNA chains. PMID- 4335585 TI - Isolation of an electrophoretically homogeneous nonhistone nucleolar protein. PMID- 4335584 TI - Fractionation and sequences of the large pyrimidine oligonucleotides from bacteriophage fd DNA. PMID- 4335586 TI - [Therapy and after care of superficial thrombophlebitis and of gynecological surgical wounds using Tanderil cream]. PMID- 4335587 TI - Prevention and treatment of sepsis in burns. PMID- 4335588 TI - Ectopic production of hormones by tumours. Pathological aspects of the para endocrine syndrome. PMID- 4335590 TI - Luteoma of pregnancy. PMID- 4335589 TI - Some clinical aspects of the para-endocrine syndromes. PMID- 4335591 TI - 'Glioma' of the uterus: a foetal homograft. PMID- 4335592 TI - [Cerebral cinegammagraphy]. PMID- 4335593 TI - An experimental study of the consequences of intraperitoneal irrigation. PMID- 4335594 TI - Bronchial adenomas. PMID- 4335595 TI - Some observation on the activity of transport ATPase in the human placenta. PMID- 4335597 TI - [Studies on relationship between clinical course, therapy and after care in hepatitis patients]. PMID- 4335598 TI - [Developmental trends in pertussis vaccines]. PMID- 4335596 TI - Hepatitis-associated antigen in patients with cancer. PMID- 4335599 TI - [Suicide prevention from the viewpoint of a regional neurologic and psychiatric hospital]. PMID- 4335600 TI - [Influence of Bordetella pertussis on the lymphatic tissue of mice. VI. Further studies regarding the influence of Bordetella pertussis on the immunological memory response]. PMID- 4335601 TI - [Therapeutic use of chlorpropamide antidiuresis in diabetes insipidus]. PMID- 4335602 TI - [Sensitivity tests in various potentially pathogenic microorganisms]. PMID- 4335603 TI - [Cancer mammarum infructuose exstirpatus by C. E. Eschenbach 1755]. PMID- 4335604 TI - Histological and histochemical observations on the capsule of the muscle spindle in normal and denervated muscle. PMID- 4335605 TI - Coronary arteries in newborn children. Intimal variations in longitudinal sections and the relationships to clinical and experimental data. PMID- 4335606 TI - The effect of cyclic adenosine 3',5' monophosphate, methyl xanthines and nicotinic acid on plasma nonesterified fatty acids in sheep. PMID- 4335608 TI - The DPNH dehydrogenase of the mitochondrial respiratory chain. PMID- 4335607 TI - New aspects of glycogen metabolism. PMID- 4335609 TI - A continuous study of viruses in the respiratory tract in families of a Calcutta bustee. I. Description of the study area and patterns of virus recovery. PMID- 4335610 TI - A continuous study of viruses in the respiratory tract in families of a Calcutta bustee. II. Family patterns of infection and illness in a crowded environment. PMID- 4335611 TI - Influence of maternal antibody on infection with virulent or attenuated Marek's disease herpesvirus. PMID- 4335612 TI - Onion bulb neuropathies. PMID- 4335613 TI - An unusual neuromuscular defect in a case of possible botulism. PMID- 4335614 TI - Myasthenic syndromes in hypothyroidism. Electrophysiological study of neuromuscular transmission and muscle contraction in two patients. PMID- 4335615 TI - A protein cofactor of lecithin:cholesterol acyltransferase. PMID- 4335616 TI - Presence of multiple protein kinase activities in rat liver nuclei. PMID- 4335617 TI - Poly 2'-deoxy-2'-aminouridylic acid. PMID- 4335618 TI - Protein kinase: altered regulation in a hepatoma cell line deficient in adenosine 3',5'-cyclic monophosphate-binding protein. PMID- 4335619 TI - The effect of gonadotrophins on the 3',5'-AMP levels of seminiferous tubules. PMID- 4335620 TI - Guanyl cyclase of Bacillus licheniformis. PMID- 4335621 TI - Reduction of nitroxide free radicals by biological materials. PMID- 4335622 TI - Studies on iron-sulfur proteins in the site I region of the respiratory chain in pigeon heart mitochondria and submitochondrial particles. PMID- 4335623 TI - A general method for the rapid measurement of enzyme precursors by the displacement of enzyme from antibody: the measurement of collagen proline hydroxylase precursor in cultured fibroblasts. PMID- 4335624 TI - [Kinetics and mechanism of H--D-exchange in free radicals of glycine monocrystals]. PMID- 4335626 TI - [Theory of the effect of a constant extracellular field on neurons]. PMID- 4335625 TI - [Study of the molecular organization of endoplasmic membranes by the spin probe method]. PMID- 4335627 TI - [Excitation energy transmission in irradiated frozen solutions of DNA and propyl gallate]. PMID- 4335628 TI - [Relation of the occurrence of an EPR signal of iron-containing complexes and free radical processes in lipids during carcinogenesis]. PMID- 4335629 TI - [Infrared spectroscopy and optical rotatory dispersion of the endoplasmic reticulum membranes of the liver of intact and tumor-bearing rats]. PMID- 4335630 TI - [Properties of the photoinduced EPR signal in green leaves]. PMID- 4335631 TI - Morphologic and biologic correlation of hyperplastic and neoplastic hepatic lesions occurring "spontaneously" In C3H x Y hybrid mice. AB - Hyperplastic and neoplastic lesions of the liver occurring "spontaneously" in C3H * Y male mice were transplanted autologously and isologously. Hyperplastic lesions did not survive in the same animal or in other animals of the same strain. Carcinomas grew in the host or in isologous mice and killed the animals. Most of the lesions were hyperplastic, and few were carcinomas. It is concluded that the histologic pattern of hyperplastic and neoplastic lesions can be correlated with the results obtained on transplantation. PMID- 4335632 TI - Invasive properties of histone transformed cells. AB - A technique was developed to study the invasion of cells into mouse kidney cortex in the presence of crude rat liver histone at a medium concentration of 100 MUg./ml. A marked increase in the invasiveness of normal cells occurred in the presence of histone. Possible explanations of this phenomenon are discussed. The invasiveness was compared with that of cells previously transformed with polyoma virus. PMID- 4335633 TI - The potential cell population doubling time in neuroblastoma and nephroblastoma. AB - Estimates are presented of the median potential cell population doubling time in five neuroblastomas and six nephroblastomas. The median time in the neuroblastomas was 4.2 days (101 hours) and in the nephroblastomas was 7.8 days (188 hours). Estimates of the duration of metaphase in the two kinds of tumour are also offered, based on the natural mitotic index in six neuroblastomas and five nephroblastomas. The findings are set in the context of a brief review of other studies on the cell population kinetics of human tumours. A more detailed but frankly speculative analysis is made of one nephroblastoma which suggests that cells are produced at the rate of at least 5 per 1000 tumour cells per hour, of which about 3 are lost. PMID- 4335634 TI - The effect of growth hormone, insulin and alloxan-induced diabetes on carcinogenesis in the genital tract of intact and castrate female rats. AB - Castrate female rats given weekly applications of DMBA to the genital tract and treated additionally with growth hormone, insulin or alloxan (to induce diabetes) are heavier and have more sarcomatous and epithelial cervico-vaginal neoplasms than intact animals under the same experimental conditions. Promotion of carcinogenesis and gain in body weight are independent phenomena caused by castration in the medicated rats. Growth hormone is most effective in enhancing body weight in all animals, but least as regards tumour formation. It reduces the incidence of sarcomas in intacts, but raises that of epithelial neoplasms, and promotes both types of neoplasms in castrates. The highest incidence of cervico vaginal epithelial and sarcomatous tumours occurs in spayed diabetics.Squamous celled epitheliomas of the vulva are not affected by castration or additional medication, while basal celled neoplasms tend to be more frequent in intacts than in castrates and particularly numerous in intact failed diabetics. Vulval sarcomas are usually rare but are increased in numbers in diabetic and in insulin treated intacts.Granular myoblastomas of the cervico-vaginal tract occur in intacts only and particularly in diabetics and those medicated with growth hormone or insulin. PMID- 4335635 TI - Cytochemistry, cytogenetics and ultrastructure of hamster tumour cells carrying mouse sarcoma viral genome (HT-1 cells). AB - The pleomorphic cytology of the HT-1 cell line is described. Cytochemical studies indicated the presence of glycogen and lysosomes in these cells. Cytogenetic studies demonstrated the presence of a large telocentric chromosome (M1) and two minute chromosomes (M2) not found in normal hamster cells. A cloned line was isolated which did not contain these marker chromosomes. All cells were hyperdiploid with chromosome number around triploidy, although none was a true triploid. Ultrastructural studies revealed the presence of "nuclear bodies", "dense bodies" and "interchromatinic granules" which have been previously described in viral induced malignancies. A few of the cells contained in their cytoplasm structures of approximately 700 [unk] in diameter which bore some resemblance to immature virus particles. Both light and electron microscopy demonstrated some nuclei lacking chromatin aggregates. This is interpreted to mean that the total genetic material of these nuclei was dispersed as free DNA not linked with histone to form chromatin aggregates. PMID- 4335636 TI - [Anahormone-chimeras. Hormonally-inactive conjugate of bovine ACTH and human somatotropin, retaining the antigenic properties of the original hormones]. PMID- 4335637 TI - [Effect of oxytetracycline (OTC) on the secretion kinetics of the rat exocrine pancreas]. PMID- 4335638 TI - Persistence of Rous sarcoma virus in transformed non-permissive cells: mechanism of virus induction by association with permissive cells in the absence of Sendai virus. PMID- 4335639 TI - Electron microscopical study of Rowson-Parr virus infection in BALB-c mice. PMID- 4335640 TI - Identity of the soluble EBV-associated antigens of human lymphoid cell lines. PMID- 4335641 TI - Effect of local radiotherapy on the antibody levels against EBV-induced early and capsid antigens (EA and VCA) in patients with certain malignant tumours. PMID- 4335642 TI - Properties of a murine sarcoma virus isolated from a tumor arising in an NZW-NZB F 1 hybrid mouse. I. Isolation and pathology of tumors induced in rodents. PMID- 4335643 TI - Properties of a murine sarcoma virus isolated from a tumor arising in an NZW-NZB F 1 hybrid mouse. II. Physical and biological characteristics. PMID- 4335644 TI - Deletion of liver-cell surface membrane components from aminoazo-dye-induced rat hepatomas. PMID- 4335645 TI - Facilitation of polyoma tumor growth in rats by blocking sera and tumor eluate. PMID- 4335646 TI - Cancer in Jewish immigrants. PMID- 4335647 TI - Carcinoma of the cervix in Jewish women in Israel, 1960-67. An epidemiological study. PMID- 4335648 TI - Primary liver carcinoma in Israel. PMID- 4335650 TI - Synthetic spectroscopic models related to coenzymes and base pairs. An "abbreviated" nicotinamide adenine dinucleotide. PMID- 4335649 TI - Epidemiology of tumors of the nervous system in Israel. PMID- 4335651 TI - Synthetic peptides related to horse heart cytochrome c. VII. Synthesis and inhibitory properties of the 70-80 undecapeptide. PMID- 4335652 TI - Detection of aflatoxin using small columns of florisil. PMID- 4335654 TI - On the nature of so-called ungulic acid. PMID- 4335653 TI - Studies on rat liver catalase. V. Incorporation of 14 C-leucine into catalase by isolated rat liver ribosomes. PMID- 4335655 TI - Hypoglycemia and erythrocytosis associated with hepatoma. PMID- 4335656 TI - Sarcoma of the prostate. Presentation as obturator nerve paralysis. PMID- 4335657 TI - Energy and electron orbitals in adenosine phosphates. PMID- 4335658 TI - Identification and genetic characterization of mutants of bacteriophage T4 defective in the ability to induce exonuclease A. AB - A mutant of bacteriophage T4 unable to induce exonuclease A has been isolated. The mutation responsible for this defect maps between genes 39 and 56, in a region of the chromosome devoid of other known markers. Four deletion mutants lacking part of the genome located between genes 39 and 56 also fail to induce exonuclease A. The ability of all of these mutants to replicate suggests that exonuclease A is not essential for replication of phage T4. PMID- 4335659 TI - Ribonucleotide reductase activity of synchronized KB cells infected with herpes simplex virus. AB - The replication of herpes simplex virus (HSV) is unimpeded in KB cells which have been blocked in their capacity to synthesize deoxyribonucleic acid (DNA) by high levels of thymidine (TdR). Studies showed that the presence of excess TdR did not prevent host or viral DNA replication in HSV-infected cells. In fact, more cellular DNA was synthesized in infected TdR-blocked cells than in uninfected TdR blocked cells. This implies that the event which relieved the TdR block was not specific for viral DNA synthesis but allowed some cellular DNA synthesis to occur. These results suggested that HSV has a means to insure a pool of deoxycytidylate derivatives for DNA replication in the presence of excess TdR. We postulated that a viral-induced ribonucleotide reductase was present in the cell after infection which was not inhibited by thymidine triphosphate (TTP). Accordingly, comparable studies of the ribonucleotide reductase found in infected and uninfected KB cells were made. We established conditions that would permit the study of viral-induced enzymes in logarithmically growing KB cells. A twofold stimulation in reductase activity was observed by 3 hr after HSV-infection. Reductase activity in extracts taken from infected cells was less sensitive to inhibition by exogenous (TTP) than the enzyme activity present in uninfected cells. In fact, the enzyme extracted from infected cells functioned at 60% capacity even in the presence of 2 mm TTP. These results support the idea that a viral-induced ribonucleotide reductase is present after HSV infection of KB cells and that this enzyme is relatively insensitive to inhibition by exogenous TTP. PMID- 4335660 TI - Analysis of simian virus 40-induced transformation of hamster kidney tissue in vitro. 8. Induction of infectious simian virus 40 from virogenie transformed hamster cells by amino acid deprivation or cycloheximide treatment. AB - Clones of virogenic simian virus 40 (SV40)-transformed hamster kidney cells were exposed to medium deficient in the essential amino acids leucine, arginine, or methionine. Infectious virus was induced after deprivation periods of from 24 to 32 hr. The highest yields of infectious SV40 were obtained from cultures deprived for 3 to 4 days. Infectious virus was also induced in cells that were treated with the metabolic inhibitor cycloheximide. Pulse labeling experiments revealed that both protein synthesis and deoxyribonucleic acid (DNA) synthesis were inhibited by concentrations of cycloheximide which were effective for virus induction. It is suggested that inhibition of protein synthesis by either amino acid deprivation or by cycloheximide was responsible for the induction of infectious virus from virogenic cells. We postulate that the inhibition of protein synthesis caused a temporary inhibition of DNA synthesis which resulted in the induction of infectious virus. PMID- 4335661 TI - Relationship between Escherichia coli B titer and the level of deoxycytidylate deaminase activity induced on bacteriophage T2r + infection. AB - The activities of six bacteriophage T2r(+)-induced enzymes (thymidylate synthetase, deoxycytidylate deaminase, thymidylate kinase, deoxycytidylate hydroxymethylase, deoxycytidine pyrophosphatase, and dihydrofolate reductase) were measured after dilution of phage-infected Escherichia coli B from 8 x 10(8) to 2 x 10(8) cells per ml. The only enzyme activity altered was that of deoxycytidylate deaminase, which increased three- to fourfold. Conversely, the rapid concentration of cells from 2 x 10(8) to 8 x 10(8) per ml did not result in a reduction in deaminase activity. Although an enhancement in aeration reduced the response of deoxycytidylate deaminase to cellular dilution, the influence of potential metabolic inhibitors or activators could not be shown. The change in deoxycytidylate deaminase activity appeared to be associated with an altered translational event, since the increase could not be prevented by rifampin but was blocked effectively by chloramphenicol and hydroxylamine. In addition, antibody to the T2 phage-induced deoxycytidylate deaminase demonstrated that the increase in enzyme activity was associated with a corresponding increase in radioactive leucine incorporated into the enzyme antigen. PMID- 4335662 TI - Gene order of the poliovirus capsid proteins. AB - Two methods were used to determine the genetic map of the poliovirus capsid proteins. The first method uses pactamycin, a drug which selectively inhibits the initiation of protein synthesis and causes a change in the relative amounts of capsid proteins synthesized. This differential effect on each of the capsid proteins is interpreted as indicating the relative distance of each protein from the initiation site of protein synthesis. The second method involves an analysis of coat precursor molecules released from polyribosomes after a series of short pulses of different length terminated by addition of emetine, a drug which stops all protein synthesis almost immediately after its addition. As the pulse length is increased, each of the capsid proteins within the precursor gains radioactivity with different kinetics. From these kinetics, it is possible to determine the gene order of the capsid proteins within the precursor as well as a rate of protein synthesis. Both methods indicate a gene order for the region of the ribonucleic acid coding for the capsid proteins as (5' --> 3') VP 4 - VP 2 - VP 3 - VP 1. PMID- 4335663 TI - Deficiency of viral ribonucleic acid-dependent deoxyribonucleic acid polymerase in noninfectious virus-like particles released from murine sarcoma virus transformed hamster cells. AB - Virions from hamster cells transformed by a new strain of murine sarcoma virus (MSV) appear to represent a form of MSV deficient in one or more of the viral components necessary for infectivity. Both the noninfectious virions and the sarcoma virus-transformed cells, which have no detectable replicating leukemia helper virus of either murine or hamster origin, are deficient in viral-type ribonucleic acid (RNA)-dependent deoxyribonucleic acid (DNA) polymerase activity (i.e., reverse transcriptase activity stimulated by the synthetic RNA-DNA template polyribo-adenylic-oligodeoxythymidylic acid). In comparison, both murine leukemia virus (MuLV) and MuLV-infected cells have abundant viral-type reverse transcriptase activity. It appears, therefore, that the leukemia virus genome may be required for the production of infectious sarcoma virus by contributing information needed for the full expression of functional viral-type reverse transcriptase. PMID- 4335664 TI - Replication of radiation-induced murine leukemia virus in normal and transformed mouse cells. AB - Autonomous radiation-induced leukemia virus (RadLV) replication could be detected in mouse 3T3 cells by the development of interference with murine sarcoma virus (MSV), the appearance of covert helper activity for defective MSV, and by the induction of cytopathic effect type foci in MSV-transformed, leukemia virus negative (S+L-) cells. A chronic infection of either 3T3 or S+L- cells with RadLV could be established. Both RadLV infectivity and helper activity were demonstrated in the same peak at a buoyant density of 1.16 g/cm(3). Additionally a soluble inhibitor of MSV focus formation was found which could be separated from infectious RadLV. Examination of cell clones derived from chronically infected 3T3 cells showed that essentially every cell was infected and produced both infectious RadLV and low levels of inhibitor. Quantitative comparisons of autonomously replicating RadLV in normal 3T3 and S+L- cells suggested that RadLV may consist of several populations of virus of varying replicative potential. Apparently 99% of RadLV can be assayed only as helper units in normal cells or as replicative units in S+L- cells. To explain the atypical results, a model for RadLV deficiency is proposed. PMID- 4335666 TI - Proposal for a uniform nomenclature for simian virus 40 mutants. AB - A uniform nomenclature for simian virus 40 mutants has been developed. This nomenclature should evolve into a comprehensive nomenclature as new mutants and information are obtained. Hopefully, his nomenclature will also stimulate the development of a comprehensive nomenclature for all animal virus mutants. PMID- 4335667 TI - [Progress in diagnosis of malignant tumor by radiopharmaceuticals]. PMID- 4335665 TI - Simple method for the isolation of encephalomyocarditis virus ribonucleic acid. AB - A simple purification procedure for encephalomyocarditis virus is described, yielding material suitable for extraction of viral ribonucleic acid for use as messenger in animal cell-free systems. PMID- 4335668 TI - The influence of guanosine 3',5'-monophosphate and other cyclic nucleotides on contractile responses induced by oxytocin in isolated rat uterus. PMID- 4335670 TI - Arterial wall irregularities in intracranial neoplasms. The shaggy vessel brought into focus. PMID- 4335669 TI - Inhibition of lysosomal enzyme release by catecholamines: possible mediation by cyclic 3',5'-adenosine monophosphate. PMID- 4335672 TI - Craniometaphyseal dysplasia. A family with three documented cases. PMID- 4335673 TI - Abdominal visceral pharmacoangiography with angiotensin. PMID- 4335671 TI - Effects of long-term thorotrast exposure. PMID- 4335674 TI - [Ocular manifestations of sinus neoplasms]. PMID- 4335675 TI - The effect of cyclic amp on Limulus lateral eye retinular cells. PMID- 4335676 TI - [Light microscopic determination of nuclear inclusion bodies in juvenile nasopharyngeal fibroma]. PMID- 4335677 TI - Light and electron microscopic observations on the pigmented layers of the developing human eye. PMID- 4335678 TI - Chloroquine toxicity in the human eye. Histopathologic observations by electron microscopy. PMID- 4335679 TI - Ultrastructure of immune deposits in renal glomeruli. PMID- 4335680 TI - The nature of the parasympathetic nerve fibres of the stomach of Rana temporaria. PMID- 4335681 TI - Actions of clonidine and 2-(2-methyl-6-ethyl-cyclohexylamino)-2-oxazoline on postganglionic autonomic nerves. PMID- 4335682 TI - Adrenergic neuron blockade by clonidine: comparison with guanethidine and local anesthetics. PMID- 4335683 TI - Mescaline: receptor interaction in the rat striatum. PMID- 4335684 TI - Cytochrome P-450 from the adrenal cortex: interaction of steroids and the hydroxylation reaction. PMID- 4335685 TI - The state of the iron atoms in hydroxylase iron-sulphur proteins. PMID- 4335686 TI - Purification of nicotinamide-adenine dinucleotide-dependent dehydrogenases by affinity chromatography. PMID- 4335687 TI - The cell and exocellular mannans from Hansenula holstii N.C.Y.C. 560. PMID- 4335688 TI - Formation of yeast protoplasts by using an enzyme preparation from Cytophaga. PMID- 4335689 TI - Inhibition by salicylate of porcine lactate dehydrogenase isoenzyme 5. PMID- 4335690 TI - Characterization of two cell-wall polysaccharides from Fusicoccum amygdali. AB - 1. The nature of two polysaccharides (s(0) (20) values 6S and 2S respectively in 1m-sodium hydroxide), comprising a fragment (fraction BB, [alpha](D) +236 degrees in 1m-sodium hydroxide), previously isolated from cell walls of Fusicoccum amygdali, has been investigated. 2. Both the major (2S) and minor (6S) components were affected by incubation with alpha-amylase. The 6S polysaccharide was also attacked by exo-beta-(1-->3)-glucanase, which is evidence that it contained both alpha-(1-->4)- and beta-(1-->3)-glucopyranose linkages. By fractionation of the products of alpha-amylase-treated fraction BB it was possible to obtain a water insoluble polysaccharide, fraction P ([alpha](D) +290 degrees in 1m-sodium hydroxide, 67% of fraction BB) and a water-soluble polysaccharide, fraction Q ([alpha](D) +16 degrees in 1m-sodium hydroxide, 11% of fraction BB), both of which sedimented as single boundaries with s(0) (20) values (in 1m-sodium hydroxide) of 1.7S and 4.6S respectively. 3. Evidence from periodate oxidation, methylation analysis, i.r. spectroscopy and partial acid hydrolysis showed that fraction P consisted of linear chains of alpha-(1-->3)-glucopyranose units with blocks of one or two alpha-(1-->4)-glucopyranose units interspersed at intervals along the main chain. The 2S polysaccharide, from which fraction P is derived, evidently also contains longer blocks of alpha-(1-->4)-glucopyranose units, that are susceptible to alpha-amylase action. 4. Fraction Q consisted of glucose (88%) with small amounts of galactose, mannose and rhamnose. Evidence from digestion with exo- and endo-beta-(1-->3)-glucanases, periodate oxidation and methylation analysis suggests that fraction Q consists of a branched galactomannorhamnan core, to which is attached a beta-(1-->3)-, beta-(1-->6)-glucan. In the cell wall, chains of alpha-(1-->4)-linked glucopyranose units are linked to fraction Q to form the 6S component of fraction BB. PMID- 4335691 TI - The energy-linked transhydrogenase reaction in respiratory mutants of Escherichia coli K12. AB - 1. Energy-linked and non-energy-linked transhydrogenase activities were assayed in membrane preparations from normal Escherichia coli K 12 and from various mutant strains. 2. The energy-linked transhydrogenase, which uses ATP as energy source, was dependent for activity on the presence of a functional Mg(2+)+Ca(2+) stimulated adenosine triphosphatase. 3. Neither of the quinones formed by E. coli, namely ubiquinone-8 and menaquinone-8, was required for normal ATP dependent energy-linked transhydrogenase activity. 4. The energy-linked transhydrogenase was inhibited by piericidin A at a site unrelated to the sites of inhibition of the electron-transport chain by piericidin A. PMID- 4335692 TI - Differences in distribution of esterase between cell fractions of rat liver homogenates prepared in various media. Relevance to the lysosomal location of the enzyme in the intact cell. AB - The distribution of esterase in subcellular fractions of rat liver homogenates was compared with that of the lysosomal enzyme acid phosphatase and the microsomal enzyme glucose 6-phosphatase. Most of the esterase from sucrose homogenate sediments with glucose 6-phosphatase and about 8% is recovered in the supernatant. However, up to 53% of the esterase can be washed from microtome sections of unfixed liver, in which less cellular damage would be expected than that caused by homogenization. About 40% of both esterase and acid phosphatase are recovered in the soluble fraction after homogenization in aqueous glycerol or in a two-phase system (Arcton 113-0.25m-sucrose), although glucose 6-phosphatase is still recovered in the microsomal fraction of such homogenates. The esterase of the microsomal fraction prepared from a sucrose homogenate is much more readily released by treatment with 0.26% deoxycholate than are other constituents of this fraction. The release of esterase from the microsomal fraction by the detergent and its concomitant release with acid phosphatase after homogenization in glycerol or the two-phase system suggests that a greater proportion of esterase may be present in lysosomes of the intact cell than is indicated by the results of standard fractionation procedures. PMID- 4335693 TI - The inactivation of phenylalanine hydroxylase by 2-amino-4-hydroxy-6,7 dimethyltetrahydropteridine and the aerobic oxidation of the latter. The effects of catalase, dithiothreitol and reduced nicotinamide-adenine dinucleotide. AB - 1. Phenylalanine hydroxylase is inhibited by its cofactor, 6,7 dimethyltetrahydropterin. The rate of inactivation, which is irreversible, increases with the concentration of cofactor. 2. Catalase, in sufficient amount relative to cofactor, prevents this inactivation. More tyrosine is formed in the presence of added catalase. 3. Dithiothreitol in the presence of liver extract also prevents inactivation of the enzyme by the cofactor and stimulates hydroxylation of phenylalanine, probably by protecting the cofactor from oxidation and regenerating it from a dihydropterin reaction product. Dithiothreitol restores linearity of rate at very low enzyme concentrations. 4. Dimethyltetrahydropterin is unstable when the solution is exposed to air but is stabilized by dithiothreitol the aerobic oxidation of which is greatly accelerated by dimethyltetrahydropterin. 5. NADH together with liver extract stabilizes the cofactor but not phenylalanine hydroxylase. 6. It is suggested that either hydrogen peroxide or an organic peroxide formed by oxidation in air of the cofactor is the substance attacking phenylalanine hydroxylase, dithiothreitol and cofactor. PMID- 4335694 TI - Structure and reactions of oxygenase active centres: cytochrome P-450 and iron sulphur proteins. PMID- 4335695 TI - Control of blood pressure. PMID- 4335696 TI - Cancer, F.D.P., and radiotherapy. PMID- 4335697 TI - Excitatory action of dibutyryl cyclic adenosine monophosphate on immature cerebral cortex. PMID- 4335698 TI - Presynaptic depolarization produced by and in identified cutaneous afferent fibres in the rabbit. PMID- 4335699 TI - Hippocampal and neostriatal inhibition of medical thalamic unit responses to somatic and brain stem stimulation. PMID- 4335700 TI - Suppression of trans-geniculate transmission during the rapid phase of caloric nystagmus in the alert squirrel monkey. PMID- 4335701 TI - [Collagenase and collagenase inhibitors in torpid corneal ulcers]. PMID- 4335702 TI - [Aniridia, nephroblastoma and genital malformations]. PMID- 4335703 TI - Peyton Rous (1879-1970). PMID- 4335704 TI - The pathology of tumors. Five. Functioning tumors, spread of cancer, the radiotherapist and the pathologist. PMID- 4335705 TI - Myocardial ultrastructure in idiopathic hypertrophic subaortic stenosis. A study of operatively excised left ventricular outflow tract muscle in 14 patients. PMID- 4335706 TI - Basement membrane changes in myocardial and skeletal muscle capillaries in myxedema. PMID- 4335707 TI - Divergent effects of theophylline on adenylate cyclase preparations from guinea pig heart and lung. PMID- 4335708 TI - The stimulating action of gastrin pentapeptide and histamine on adenyl cyclase activity in rat stomach. PMID- 4335709 TI - Quantitative evaluation of the rate of mineralization of induced skeletal tissues by the electron spin resonance technique. PMID- 4335710 TI - Cholinergic mechanism in the inhibition of spinal reflexes from the superficial radial nerve of the decerebrate cat. PMID- 4335711 TI - Epstein-Barr virus and inflammatory bowel disease. PMID- 4335712 TI - Transspecific variability of D-fructose-1,6-diphosphate-1-phospholhydrolase (e.c.: 3.1.3.11) in Primates. PMID- 4335713 TI - Progressive changes in the enzyme levels of mouse foetal liver. PMID- 4335714 TI - Effect of hypertonic calcium chloride upon the fine structure of human spermatozoa. PMID- 4335715 TI - The effect of anti-FSH serum on the reproductive organs of the male rat. PMID- 4335716 TI - The cervical mucus: interaction of oesradiol and megestrol acetate. PMID- 4335718 TI - Critical study of the retarded progestational phase. PMID- 4335717 TI - Newtonian viscosity of the human cervical mucus during the menstrual cycle. PMID- 4335719 TI - Infertility associated with induced local antibody secretion against sperm in the bovine uterine cervix. PMID- 4335720 TI - Free radical distribution in gamma-irradiated DNA. PMID- 4335721 TI - Computer analysis and reconstruction of E.S.R. spectra of gamma-irradiated DNA. PMID- 4335722 TI - Mechanisms of radical formation in irradiated purine bases and derivatives: an E.P.R. study using computer technique. PMID- 4335723 TI - Radical transformation in irradiated cytosine and derivatives as studied by E.P.R. PMID- 4335724 TI - The effect of a long acting estrogen on the activity and distribution of some hydrolases in the ventral prostate of intact, castrated, and androgen treated castrated adult rats. PMID- 4335725 TI - Ultrastructural examination of homograft human renal biopsies from anastomosis to nephrectomy. PMID- 4335726 TI - Isometric studies on canine urethral musculature. PMID- 4335727 TI - Carcinoma of the lung: 352 cases. PMID- 4335728 TI - Stereochemistry of low-spin iron porphyrins. I. Bis(imidazole)- , , , tetraphenylporphinatoiron(3) chloride. PMID- 4335729 TI - Stereochemistry of low-spin iron porphyrins. II. Bis(piperidine)- , , , tetraphenylporphinatoiron(II). PMID- 4335730 TI - Effect of chemical sympathectomy on the content of acetylcholine, choline and choline acetyltransferase activity in the cat spleen and iris. AB - 1. Acetylcholine and choline were measured in the spleens and irides of normal and 6-hydroxydopamine-treated cats. In addition, choline acetyltransferase activity was measured in the spleens.2. No acetylcholine or choline acetyltransferase activity were found in spleens of normal or treated cats. The choline content of normal spleens was 12.4 +/- 1.5 mug/g wet wt. (mean +/- S.E. of mean), which was not significantly altered by chemical sympathectomy.3. The acetylcholine and choline contents of the cat iris were 3.0 +/- 0.3 mug/g wet wt. and 7.7 +/- 0.9 mug/g wet wt., respectively. There was no difference in acetylcholine and choline concentrations between left and right or normal and sympathectomized irides.4. These results are discussed in relation to the question of a cholinergic link in post-ganglionic sympathetic transmission. PMID- 4335731 TI - Influence of the carotid rete on brain temperature in cats exposed to hot environments. AB - 1. Thermocouples were chronically implanted in various intracranial and extracranial structures in adult cats. Temperature of arterial blood on the proximal and distal sides of the carotid rete was determined by measuring temperature in the aortic arch and at the anterior cerebral arteries. Temperatures of brain stem regions supplied by the carotid rete and by the vertebral-basilar system were determined by measuring temperature in the anterior hypothalamus and the caudal medulla. Nasal mucosal temperature was measured with a thermocouple implanted in the nasal cavity.2. In a cool environment (25 degrees C), the temperature of anterior cerebral arterial blood was lower than aortic arterial temperature. Anterior cerebral temperature showed shifts which were not present in central (aortic) arterial blood and which were clearly associated with changes in heat loss from the nasal mucosa and with the behaviour of the animal. When the cats were relaxed or in e.e.g. slow-wave sleep, the nasal mucosal temperature was high and the temperature at the anterior cerebral arteries was as much as 0.30 degrees C less than aortic temperature. During behavioural arousal and paradoxical sleep, the nasal mucosal temperature fell and the anterior cerebral arterial temperature rose toward central arterial temperature. Shifts in hypothalamic temperature followed the changes in anterior cerebral arterial temperature. Medullary temperature was higher than aortic temperature and showed shifts which suggested that blood from the rostral circle of Willis mixed with vertebral blood in the basilar artery.3. When the ambient temperature was raised to 40-45 degrees C the cooling of cerebral arterial blood and brain increased as the rate of thermal panting increased. Respiratory rate increased tenfold and aortic temperature rose by 2.0-2.5 degrees C. Anterior cerebral arterial temperature fell below aortic temperature by as much as 1 degrees C, hypothalamic temperature dropping in parallel with cerebral arterial temperature. Medullary temperature cooled below aortic temperature during heat exposure, but the temperature drop in the medulla was not as high as in the rostral brain stem.4. Blowing air into the nasal cavity of anaesthetized cats produced a large, rapid temperature drop at the anterior cerebral arteries and in the hypothalamus, with little effect on central arterial temperature. The same experiments in a dead animal cooled the brain after a longer period of time, suggesting that an active process is involved in the brain cooling observed in living animals.5. It is concluded that the cooling of the rostral cerebral arterial blood and brain which occurs in cats in a cool environment and is accelerated during thermal panting, is a result of countercurrent heat exchange between arterial blood in the carotid rete and venous blood draining the evaporative surfaces of the upper respiratory passages. Such direct brain cooling during thermal panting has now been demonstrated in the cat, the sheep and the gazelle, and probably explains the high heat tolerance of the carnivores and hoofed mammals in which a rete is present. PMID- 4335732 TI - The cellular analysis of liver carcinogenesis. V. Ultrastructural alterations within hepatocellular carcinoma induced by ethionine. PMID- 4335733 TI - Regeneration of human muscle. A morphologic and histochemical study of normal and dystrophic muscle after injury. PMID- 4335734 TI - Effects of cellulose phosphate and sodium phosphate on formation product and activity product of brushite in urine. PMID- 4335736 TI - [Congenital malformations caused by amniotic adhesions. Case of furrows, amputations and syndactylia]. PMID- 4335735 TI - Androgen production in boys with sexual precocity and congenital adrenal hyperplasia. PMID- 4335738 TI - Battered-patient therapy. PMID- 4335737 TI - Psychiatric disturbance in endocrinologic disease. PMID- 4335739 TI - [Articular chondrocalcinosis and rheumatoid arthritis]. PMID- 4335740 TI - [Potter's syndrome and polycystic kidney in the newborn]. PMID- 4335741 TI - [Rubella: results of a three-year immunologic study. Prophylaxis in pregnant women. Vaccination with the Plotkin strain]. PMID- 4335742 TI - [Vulvovaginal moniliasis and oral contraceptives. (Statistical study of 496 subjects)]. PMID- 4335743 TI - [Sever complications due to subcutaneous calcium heparinate observed in neurosurgery]. PMID- 4335745 TI - [Acute kidney failure in Truxal poisoning]. PMID- 4335744 TI - Effects of lead acetate on platelet aggregation, ultrastructure and serotonin release. PMID- 4335746 TI - Inverted diurnal rhythm of cellular autophagy in liver cells of rats fed a single daily meal. PMID- 4335747 TI - [Ear lobe tumour induced in ovariectomized rats by dimethylbenzanthracene. Dermatofibrosarcoma protuberans]. PMID- 4335748 TI - [Early ultrastructural changes of skeletal muscle capillaries of the rat after local x-radiation]. PMID- 4335749 TI - Ultrastructure of the small intestinal epihelium of the developing pig foetus. PMID- 4335750 TI - On the dermal innervation. PMID- 4335752 TI - [Electrophysiological study of external inhibition]. PMID- 4335751 TI - [Dynamics of disorders of internal inhibition following damage to the caudate nuclei and amygdala]. PMID- 4335753 TI - [Paradoxical sleep in newborn infants]. PMID- 4335754 TI - [Neurophysiological mechanisms of action of barbiturates on the brain projection systems]. PMID- 4335755 TI - Effect of NADH on the ceruloplasmin catalyzed oxidation of dopamine and noradrenaline. PMID- 4335756 TI - The cytology of acute bacterial and follicular conjunctivitis. PMID- 4335757 TI - Cytology of ocular lesions. PMID- 4335758 TI - Recognition of female subpopulations with cancer and risk of cancer. PMID- 4335759 TI - Respiratory viruses of cattle. PMID- 4335760 TI - Conformational studies on polypeptides. The effect of sodium perchlorate on the conformation of poly-L-lysine and of random copolymers of L-lysine and L phenylalanine in aqueous solution. PMID- 4335761 TI - [Arboviruses in the Ivory Coast. Serologic study in the human population of the Abengourou area]. PMID- 4335762 TI - [Inhibitory effects of exogenous glucose on protoheme biosynthesis by the yeast Saccharomyces cerevisiae]. PMID- 4335763 TI - [Study of blood sugar in rats after administration of different quantities of thiazolidine-4-carboxylic acid]. PMID- 4335764 TI - [Geographical distribution of bovine pancreatic lithiasis in France: influence of subsoil type]. PMID- 4335765 TI - [Study of some respiratory enzymatic systems and protein metabolism of BHK 21 cells infected with Myxovirus parainfluenzae I]. PMID- 4335766 TI - [Culture of normal and tumoral cells. Comparative study of different technics of liver dissociation]. PMID- 4335767 TI - The natural history of viral hepatitis. PMID- 4335768 TI - Human volunteer and tissue culture studies of viral hepatitis. PMID- 4335769 TI - Treatment of viral hepatitis. PMID- 4335770 TI - The community group program: evaluation of a multi-agency therapeutic social club. PMID- 4335771 TI - Treatment of choreoathetotic movements in chronic liver disease with a dopamine blocking agent. Pathophysiologic implications. PMID- 4335772 TI - Cryoglobulinemia and cerebrovascular accident. PMID- 4335773 TI - Specialized organizational patterns within the nucleus reticularis thalami of the cat. PMID- 4335774 TI - Degeneration of taste buds and lateral line organs in the salamander treated with cholinolytic drugs. PMID- 4335775 TI - Effect of a single injection of L-thyroxine on glycogen, and on glycolytic and other enzymes in propylthiouracil-fed cockerels. PMID- 4335776 TI - [Ultrastructure, histochemistry and physiology of the pre-evulatory follicle and corpus luteum in the ovoviviparous urodele Salamandra salamandra (L)]. PMID- 4335777 TI - Hypophysial corticotropic function and its hypothalamic control in Bufo bufo (L.) evaluated by the plasma concentration of corticosterone. PMID- 4335778 TI - Differentiation of male chick oviducts under hormonal stimulation. PMID- 4335779 TI - Seasonal changes in endocrine organs of the male common frog, Rana temporaria. 3. The gonads and cholesterol cycles. PMID- 4335780 TI - Hormonal regulation of the skin diffusional permeability to water during development and metamorphosis of Xenopus laevis Daudin. PMID- 4335781 TI - [Principles and results in the examination and treatment of supraglottic laryngeal carcinoma]. PMID- 4335782 TI - On the metabolism of sphinganyl- and sphingenyl-1-phosphorylcholine. PMID- 4335783 TI - Ubiquinone in the lysosomal membrane fraction of rat liver. PMID- 4335784 TI - Studies on the immune response and pathogenesis of Sendai virus infection of mice. I. The fate of viral antigens. PMID- 4335785 TI - Studies on the respiratory system of Aspergillus oryzae. IV. Low temperature difference spectra of mitochondria from mycelia grown in the presence and absence of chloramphenicol. PMID- 4335786 TI - Activation of muscular phosphorylase b kinase by a minute amount of Ca ion. PMID- 4335787 TI - Effects of adrenalectomy and castration on enzymes metabolizing drugs in mouse liver. PMID- 4335788 TI - The difference absorption spectrum of myosin induced by adenosine triphosphate, adenosine diphosphate, and inorganic pyrophosphate. PMID- 4335789 TI - Multiplication of some porcine enteroviruses in baby hamster and pig kidney cell lines. PMID- 4335790 TI - Effects of radiation on specific cellular immunities: besnoitiosis and a herpesvirus infection of hamsters. PMID- 4335791 TI - Relation between naturally acquired immunity and infectivity of two rhinoviruses in volunteers. PMID- 4335792 TI - The susceptibility of Bacteroides fragilis to 24 antibiotics. PMID- 4335793 TI - Stimulation of intestinal secretion in vitro by culture filtrates of Escherichia coli. PMID- 4335794 TI - Cytomegalovirus macroglobulin in cell-associated herpesvirus infections. PMID- 4335795 TI - Identification of a xylose-containing cerebroside in the salt gland of the herring gull. AB - A pentose-containing cerebroside has been identified in the salt gland of the herring gull, using mass spectrometry of acetyl and trimethylsilyl derivatives. A detailed interpretation of the spectra allowed a conclusion concerning the major long-chain base (the C(20) homolog of sphingosine) and the major fatty acids (C(22)-C(25) 2-hydroxy fatty acids), using reference spectra of synthetic galactosylceramides. A six-membered glycose ring (aldopyranose) was demonstrated by mass spectrometry of the acetyl derivative of periodic acid-oxidized and sodium borodeuteride-reduced pentosylceramide. By gas-liquid chromatography and mass spectrometry of methanolysis products, the pentose was shown to be identical with xylose. The procedures were applied to 25-50 micro g of glycolipid. PMID- 4335796 TI - Concentration gradient electrophoresis of plasma from patients with hyperbetalipoproteinemia. AB - A modification of the Pratt and Dangerfield technique of acrylamide gel concentration gradient electrophoresis has been used to study low density lipoproteins from fasting human beings. Prestained plasma from normal subjects and from patients with Fredrickson's type II hyperbetalipoproteinemia was electrophoresed in continuous gradient gel columns (approximately 3.5-8%). Reproducible low density lipoprotein patterns were obtained, and two major bands of low density lipoproteins as well as trace amounts of two to five other low density lipoproteins were seen in normal plasma. Plasmas from patients with hyperbetalipoproteinemia were more heterogeneous. Abnormal plasmas showed as many as six major low density lipoprotein bands and six minor bands. Patterns were constant for an individual but varied between patients. The major bands frequently had obviously different mobilities from those in normal plasma. Extensive experiments, using a large number and variety of mixed plasmas (normal, type II, and others) or plasmas run separately in divided gel columns, led to a numbering system of the low density lipoproteins comprised of 15 discrete bands. In addition to the changes seen in the low density lipoproteins in patients with hyperbetalipoproteinemia, reduced amounts of high density lipoproteins were consistently found. PMID- 4335797 TI - Exchange of phospholipids between low and high density lipoproteins of squirrel monkeys. AB - Ultracentrifugal analysis of the plasma of squirrel monkeys at various times after the injection of [Me-(14)C]choline revealed the specific activities of lecithin in both high (HDL) and low (LDL) density lipoproteins to be similar. This was also true for sphingomyelin. The exchange of phospholipids in vitro was studied by incubating unlabeled plasma with labeled LDL and HDL isolated 40 hr after the injection of [Me-(14)C]choline. Recentrifugation of plasma immediately after the addition of either (14)C-labeled LDL or HDL demonstrated that significant exchanges of both lecithin and sphingomyelin had occurred. In further studies, (14)C-labeled LDL or HDL were incubated with plasma and the low density lipoproteins were rapidly isolated by precipitation with heparin-Mn(2+). Complete equilibration of lecithin and sphingomyelin between LDL and HDL was attained after 4 and 5 hr, respectively. The fractional exchange rates for lecithin and sphingomyelin of LDL to HDL were 0.60 hr(-1) and 0.45 hr(-1). Corresponding values for HDL to LDL were 0.51 hr(-1) and 0.53 hr(-1). Inhibition of plasma lecithin:cholesterol acyltransferase reduced the exchange of sphingomyelin but had no effect on lecithin exchange. The rates of exchange of four lecithin subfractions of different unsaturation between LDL and HDL were the same. PMID- 4335798 TI - Very low density lipoproteins and lipoprotein lipase in serum of rats deficient in essential fatty acids. AB - Rats fed a diet deficient in essential fatty acids have a low level of serum very low density lipoproteins (VLDL). It was found that after intraperitoneal injection of heparin, deficient rats had a higher level of lipoprotein lipase activity in their plasma than did normal rats. VLDL isolated from serum of normal and deficient rats were compared as substrates for postheparin lipase of rat plasma. There was no significant difference in V(max) between the two preparations of lipoproteins, but the apparent K(m) for lipoproteins from deficient animals was significantly less than that for normal animals. These observations suggest that the low concentration of VLDL in deficient rats may be explained (a) by an increased activity of lipoprotein lipase in the tissues of these animals and (b) by the VLDL of deficient rats being more rapidly hydrolyzed at low concentrations by lipoprotein lipase than VLDL from normal rats. PMID- 4335799 TI - Effects of starvation, refeeding, and fat feeding on adipocyte ghost adenyl cyclase activity. AB - Basal adenyl cyclase activity and its response to epinephrine and glucagon were studied in isolated adipocyte ghosts obtained from fed, starved, refed, and fat diet-adapted rats. Epinephrine stimulation of adenyl cyclase was significantly increased in fasted rats, but the glucagon response did not change. Rats fasted for 48 hr and refed a high carbohydrate, low fat diet for 48 or 96 hr showed no differences from chow-fed animals in either basal or hormone-stimulated adenyl cyclase activity. Rats adapted to a high fat, low carbohydrate diet showed an initial and transitory increase in basal activity but a progressive loss of epinephrine- and glucagon-stimulated enzyme activities. The loss in hormone responsiveness correlated well with a decrease in hormone-stimulated lipolysis of fat pads and was associated with a significant increase in fat cell diameter. PMID- 4335800 TI - The correlation of maternal cytomegalovirus infection during varying stages in gestation with neonatal involvement. PMID- 4335801 TI - Congenital nephroma of infancy: induction of renal structures by organ culture. PMID- 4335802 TI - Some properties of the presynaptic nerve terminals in a mammalian sympathetic ganglion. AB - 1. Superior cervical ganglia of adult rats were excised and maintained in vitro in stable conditions. Potentials were recorded with external electrodes. After transmission was blocked by mecamylamine, a small potential change was recorded from the rostral area of the ganglion in response to preganglionic stimulation.2. This electrical response was identified as the presynaptic action potential recorded from the nerve terminals by a number of criteria based on histological and physiological considerations including the disappearance of the spike in a glucose free solution. As shown by Nicolescu, Dolivo, Rouiller & Foroglou Kerameus (1966) on the same preparation this condition causes an irreversible and selective lesion of the presynaptic nerve endings.3. A suitable concentration of mecamylamine permitted the presynaptic response and the excitatory post-synaptic potential (EPSP) to be recorded simultaneously. As the stimulus was increased, the EPSP increased linearly with the amplitude of the presynaptic response.4. After replacement of potassium ions in the bathing solution by caesium and during the early phase of post-tetanic facilitation there was an increase in the presynaptic response accompanied by a disproportionate increase in the EPSP.5. No changes in the presynaptic response were found in the presence of the following drugs, all of which depressed the EPSP: acetylcholine, hemicholinium, curare, further doses of ganglion-blocking agents, and high Mg(2+) and low Ca(2+) concentrations.6. Ouabain (4.5 x 10(-4)M) reversibly decreased the amplitude of the presynaptic response and increased the spontaneous release of transmitter. The EPSP was at first enhanced and then depressed. PMID- 4335804 TI - An electrophysiological analysis of the storage of acetylcholine in preganglionic nerve terminals. AB - 1. An electrophysiological analysis has been made of the storage of acetylcholine (ACh) in the preganglionic nerve terminals of the isolated superior cervical ganglion of the guinea-pig. The mean amplitude of excitatory post-synaptic potentials recorded intracellularly was taken as a measure of the ACh output per impulse from the terminals of a preganglionic axon.2. Prolonged repetitive stimulation of the cervical sympathetic trunk at 10 and 20 Hz in the presence of hemicholinium No. 3 led to an exponential decline of ACh output as the transmitter formed before the beginning of stimulation was depleted.3. The rate of decline of ACh output during stimulation at 20 Hz (tau = 0.83-1.95 min) was about twice as fast as that at 10 Hz (tau = 1.00-6.83 min).4. The results suggest that, during prolonged stimulation, ACh is released from a single store in the preganglionic nerve terminal and that each impulse releases a constant fraction of the store of the transmitter. PMID- 4335803 TI - Modification of the evoked release of noradrenaline from the perfused cat spleen by various ions and agents. AB - 1. Cat spleens were perfused with Krebs-bicarbonate solution at a rate of about 7 ml./min at 33-35 degrees C. Noradrenaline release after splenic nerve stimulation at 10 or 30 Hz was measured. Effects of various ions and drugs on noradrenaline release were determined.2. Perfusion of phenoxybenzamine- and [(3)H]noradrenaline treated spleens with 1, 2.5 and 5 mM cobalt or nickel-2 Krebs solution markedly reduced the release of noradrenaline by nerve stimulation. Lanthanum was the most potent inhibitor of noradrenaline release. Increasing the calcium concentration or adding tetraethylammonium chloride (TEA) partially counteracted the inhibitory effects of cobalt on release. Cobalt did not inhibit release induced by tyramine.3. Calcium did not cause spontaneous release of noradrenaline either when high concentrations were injected directly into the spleen or after first perfusing the spleen with calcium-free medium.4. Carbachol, protoveratrine and high potassium inhibit, whereas TEA, barium and rubidium enhance, the evoked release of noradrenaline.5. The relation of noradrenaline release to influx of calcium ions and its modification by various agents has been discussed. PMID- 4335805 TI - [Significance of determination of alpha-fetoprotein in surgery of hepatic cancer]. PMID- 4335807 TI - Use of physical therapy in neurological disorders. PMID- 4335806 TI - [30-year survival after perineal amputation for rectosigmoid cancer]. PMID- 4335808 TI - Epidemiology of Clostridium perfringens food poisoning. PMID- 4335809 TI - Influence of repeated immobilization stress upon the circadian rhythmicity of adrenocorticoid biosynthesis. PMID- 4335810 TI - Effects of dexamethasone and stressful stimuli on hypothalamic electrical activity in rats with diencephalic islands. PMID- 4335812 TI - Psychiatric community nurses in Edinburgh. PMID- 4335811 TI - Short-latency suppression of pituitary-adrenal function with physiological plasma levels of corticosterone in the female rat. PMID- 4335813 TI - [Juvenile angiofibroma of the nasopharynx and evaluation of therapeutic methods]. PMID- 4335815 TI - [Value of direct breast lymphography]. PMID- 4335814 TI - [Experimental results in visceral lymphography]. PMID- 4335816 TI - [Angiographic demonstration of an unusually large chemodectoma of the carotid glomus (glomus tumor)]. PMID- 4335817 TI - Medical Grand Rounds from the University of Alabama Medical Center. Lead poisoning. PMID- 4335818 TI - Multiple primary cancers in separate tissues: case report and brief review. PMID- 4335819 TI - [Malacoplakia of the urinary bladder: histological, cytological and electron microscopic studies]. PMID- 4335820 TI - Malacoplakia of the testis and epididymis. (Macrophagic-induction epididymo orchitis). PMID- 4335822 TI - [Cystadenosarcoma of the ovary]. PMID- 4335821 TI - [Autoradiographic studies on RNA metabolism during dibutylnitrosamime-induced bladder tumors in rats]. PMID- 4335823 TI - Effects of 8-lysine-vasopressin and synthetic analogues of release of ACTH. PMID- 4335825 TI - Effect of potassium intake on the final steps of aldosterone biosynthesis in the rat. II. 11 -hydroxylation. PMID- 4335824 TI - Microchemical analysis of human tibial growth cartilage in various forms of dwarfism. PMID- 4335828 TI - Comparison of cytopathic effects of a classical isolate of Marek's disease virus in cell cultures of duck embryo fibroblasts and chicken kidney. PMID- 4335826 TI - Studies on the lipids of Plasmodium knowlesi-infected rhesus monkeys (Macaca mulatta). 3. Changes in liver lipids. PMID- 4335829 TI - Marble spleen disease in ring-necked pheasants: histology and ultrastructure. PMID- 4335830 TI - Spectrum of infectivity and transmission of the T-virus. PMID- 4335831 TI - The nicotine adenine dinucleotide requirement of Mycoplasma synoviae. PMID- 4335832 TI - Precipitating antibody development in birds infected with Marek's disease virus. PMID- 4335833 TI - Phosphate acceptor specificity during oxidative phosphorylation in submitochondrial particles. PMID- 4335834 TI - NAD + -induced phosphate acceptor specificity in submitochondrial systems. PMID- 4335835 TI - Retarded reduction of cytochrome b 5 following the aerobic-anaerobic transition of intact rat liver mitochondria. PMID- 4335836 TI - Biochemical and biophysical studies on cytochrome aa 3 . V. Binding of cyanide to cytochrome aa 3 . PMID- 4335837 TI - Biochemical and biophysical studies on cytochrome aa 3 . VI. Reaction of cyanide with oxidized and reduced enzyme. PMID- 4335838 TI - Heme-heme interaction in cytochrome oxidase. PMID- 4335839 TI - Actions of tetraphenylboron on the electron flow in photosystem II of isolated chloroplasts. PMID- 4335840 TI - Nitrogenase. II. Changes in the EPR signal of component I (iron-molybdenum protein) of Azotobacter vinelandii nitrogenase during repression and derepression. PMID- 4335841 TI - [The cytochromes of cytoplasmic and mesosomal membranes of Bacillus subtilis]. PMID- 4335842 TI - Complexing of riboflavin with the enolate form of barbituric acid. PMID- 4335843 TI - Effect of pH on cytochromes b in ATP-Mg submitochondrial particles. PMID- 4335844 TI - The bacterial nitrate reductases: EPR studies on nitrate reductase A from Micrococcus denitrificans. PMID- 4335845 TI - War neuroses and the adaptive function of REM sleep. PMID- 4335846 TI - [New perspectives in the treatment of corneal ulcers]. PMID- 4335847 TI - [Spreading depression]. PMID- 4335848 TI - Prostaglandin-induced inhibition of vascular tone and reactivity in the cat's hindleg in vivo. PMID- 4335849 TI - Effects of nerve stimulation on the uptake of norepinephrine by the perfused spleen of the cat. PMID- 4335850 TI - Effects of 4,4'-biphenylene-bis-(2-oxoethylene)-bis-(2,2-diethoxyethyl) dimethylammonium dibromide (DMAE) on catecholamines released by angiotensin. PMID- 4335851 TI - Cholinolytic effects of 3,3-dimethylbutanol carbamate (DBC). PMID- 4335853 TI - Studies on the etiology of nasopharyngeal carcinoma. PMID- 4335852 TI - Bacterial flora in the alimentary tract of chickens infected with Eimeria brunetti and in chickens immunized with Eimeria maxima and cross-infected with Eimeria brunetti. PMID- 4335854 TI - Inhibition of biological activity of cholecalciferol (vitamin D3) by o,p'-DDT or p,p'-DDT in Rachitic cockerel. PMID- 4335856 TI - Inactivation of an alkaline bacillopeptidase by pentasodium triphosphate. PMID- 4335855 TI - Effects of organochlorine insecticides on metabolism of cholecalciferol (vitamin D 3 ) in Rachitic cockerel. PMID- 4335857 TI - Effects of L-dopa in autism. PMID- 4335858 TI - Chemical studies of structural features in staphylococcal nuclease-T'. PMID- 4335859 TI - Kinetic and magnetic resonance studies of the mechanism of D-xylose isomerase. I. Binary and ternary complexes with manganese(II), substrates, and inhibitors. PMID- 4335861 TI - Enzymatic -oxidation. VI. Isolation of homogeneous reduced diphosphopyridine nucleotide-rubredoxin reductase. PMID- 4335860 TI - Inactivation of T u factor-guanosine triphosphate recognition and ribosome binding ability by terminal oxidation-reduction of yeast phenylalanine transfer ribonucleic acid. PMID- 4335862 TI - The partial purification of thiamine triphosphatase from rat brain. PMID- 4335863 TI - Human phosphoribosylpyrophosphate synthetase. Kinetic mechanism and end product inhibition. PMID- 4335864 TI - The effect of pyridoxal phosphate modification on the catalytic and regulatory properties of bovine liver glutamate dehydrogenase. PMID- 4335865 TI - The structure of the glycopeptides of a human M-immunoglobulin. PMID- 4335866 TI - Nonequivalence of the flavin adenine dinucleotide moieties of chicken liver xanthine dehydrogenase. PMID- 4335867 TI - D-Fucose metabolism in a pseudomonad. I. Oxidation of D-fucose to D-fucono- lactone by a D-aldohexose dehydrogenase. PMID- 4335868 TI - D-Fucose metabolism in a pseudomonad. 3. Conversion of D-fuconate to 2-keto-3 deoxy-D-fuconate by a dehydratase. PMID- 4335869 TI - A membrane-bound pyrophosphatase in Escherichia coli catalyzing the hydrolysis of cytidine diphosphate-diglyceride. PMID- 4335871 TI - Boric acid-silica dusts for control of German cockroaches. PMID- 4335870 TI - Requirement for guanosine triphosphate in the prostaglandin activation of adenylate cyclase of platelet membranes. PMID- 4335872 TI - [State of the glucocorticoid function of the adrenal cortex in patients with coronary arteriosclerosis]. PMID- 4335873 TI - [Acrocephalosyndactyly--Apert's Syndrome]. PMID- 4335874 TI - Histometric study of neuromuscular junction ultrastructure. II. Myasthenic syndrome. PMID- 4335875 TI - [Mitochondrial structure proteins--conformation of mitochondrial structure proteins in normal rat liver and AH-130 hepatoma]. PMID- 4335876 TI - [Nivaline in neurological therapy (report of 100 cases)]. PMID- 4335877 TI - [Alveolar proteinosis in infants coexisting with viral (cytomegalo-virus and measles virus) and microbial infections]. PMID- 4335879 TI - [15 superficial cancers of the stomach. Diagnosis by fibroscopy with directed biopsy]. PMID- 4335878 TI - [Antibiotics in pediatrics]. PMID- 4335880 TI - [Primary lymphoid infiltrations of the stomach]. PMID- 4335881 TI - [Migration of hepatocarcinoma fragments into the bile ducts. Apropos of 3 cases]. PMID- 4335882 TI - [Intraparietal hematomas of the small intestine during anticoagulant treatment]. PMID- 4335883 TI - [Diffuse eosinophilic granuloma of the digestive tract]. PMID- 4335885 TI - [Intestinal tuberculosis and methemoglobinemia]. PMID- 4335886 TI - [Amputation neuroma of the abdominal pneumogastric nerve]. PMID- 4335884 TI - [Embolisms of the superior mesenteric artery]. PMID- 4335888 TI - [Transplantation of a cornea dehydrated with silicagel]. PMID- 4335887 TI - [8 emergency portacaval anastomoses in liver cirrhosis patients]. PMID- 4335889 TI - [1st experience in the use of collagenase in corneal diseases]. PMID- 4335890 TI - The existence of nonfunctional active sites in milk xanthine oxidase: reaction with functional active site inhibitors. PMID- 4335891 TI - [Bronchial carcinoma in younger people]. PMID- 4335892 TI - [Effect of trace element deficiencies on enzymes]. PMID- 4335893 TI - Fluorescein angiographic studies of the peripapillary and perilimbal regions in simple, capsular and low-tension glaucoma. PMID- 4335894 TI - The prevention of hospitalization in schizophrenia: five years after an experimental program. PMID- 4335895 TI - A comparative study of the psychiatric care of Indian and Metis. PMID- 4335896 TI - Studies on proteins of animal ribosomes. IX. Proteins of ribosomal subunits of some tumors characterized by two-dimensional polyacrylamide gel electrophoresis. PMID- 4335897 TI - [Determination of estradiol receptors in human breast carcinoma]. PMID- 4335898 TI - Adenovirus precipitating antibodies in the sera of some domestic animal species in Ireland. PMID- 4335899 TI - The effect of pyrophosphate infusion on the response of the thyroparathyroidectomized rat to parathyroid hormone and adenosine-3',5'-cyclic monophosphate. PMID- 4335900 TI - Mammography and cancer of the breast. PMID- 4335901 TI - Inhibition of lymphocyte recirculation by stress and corticotropin. PMID- 4335902 TI - [Avian myeloblastosis virus. Model for study of leukemia due to virus]. PMID- 4335903 TI - [Tumorgenesis by type B particles (mammary tumor virus) in the mouse and implications for human pathology]. PMID- 4335904 TI - [State of the immunobiological reactivity in neonates whose mothers have been exposed to chemical substances at petrochemical plants]. PMID- 4335905 TI - [Alveolar phagocytosis of industrial manganese, feldspar, and rock crystal dusts]. PMID- 4335906 TI - [Determination of free silicon dioxide in suspended mine dust]. PMID- 4335907 TI - [Studies on the distribution of enzyme proteins in liver-cell endoplasmic membranes. I. Separation of rat liver microsomes by differential and zonal centrifugation]. PMID- 4335908 TI - Lack of correlation between poly ADP-ribose formation and DNA synthesis. PMID- 4335910 TI - NAD-dependent alpha-glycerophosphate dehydrogenase in the housefly, Musca domestica. PMID- 4335909 TI - Fine structure of the myenteric plexus in the guinea-pig ileum. PMID- 4335911 TI - Observations on the transmitter function of noradrenaline in the central control of body temperature in the rabbit. PMID- 4335912 TI - Modifications of dorsal horn cell activities in the spinal cord, after intra arterial injection of bradykinin. AB - 1. A method is described to study the modification in the activity of the lamina IV and V cells of the dorsal horn under the intra-arterial administration of bradykinin into the hind limb of the spinal cat.2. The modifications induced by intra-arterial injection of bradykinin preferentially affected the lamina V cells (77% of the units) and produced few changes in the lamina IV cells (16% of the units showed variations).3. 52% of the lamina V cells were activated; the mean increase in the firing rate was 700%. The mean latency of the effect was 20 sec and the mean duration was 47 sec. However, there was large variance in the excitatory effect across cells. On the other hand, for the same cell, the observed effects were perfectly reproducible and injections of physiological fluid induced no response.4. 25% of the lamina V cells were inhibited. Generally, the activity of the cell was reduced to 13% of its initial value; in some cases, a total suppression of activity was observed. The mean latency of the inhibitory effect was 12 sec and its duration 28 sec. All these units had a very wide inhibitory field (activated by stimulations of low intensity) which asymmetrically surrounds the excitatory field.5. This study confirms the role played by the lamina V cells in the transmission of nociceptive messages. The existence of inhibitory phenomena is in favour of the gate control theory described by Melzack & Wall (1965) without deciding the pre- or post-synaptic nature of these mechanisms. PMID- 4335914 TI - Degeneration of sympathetic nerves in vitro and development of smooth muscle supersensitivity to noradrenaline. AB - 1. The sequence of events involved in degeneration of sympathetic nerve terminals has been studied in vitro in the expansor secundariorum muscle of the chicken.2. The muscle underwent a degeneration contraction due to abrupt release of noradrenaline stores from the nerves about 18 hr after isolation. The tension reached its peak within 6 hr at about 44% of the maximum tension developed to added noradrenaline.3. Responses to nerve stimulation were transiently potentiated by 35% on average just before the onset of the degeneration contraction and then failed abruptly.4. Degeneration release of noradrenaline was Ca(2+)-dependent. Development of the degeneration contraction was delayed by temporary withdrawal of Ca(2+) from the medium and was accelerated by a twofold increase in Ca(2+) concentration when applied at a critical period close to the onset.5. Neither continuous nerve stimulation nor alterations in the length of the nerve stump influenced the course of the degeneration contraction in vitro.6. When the muscle was left in situ after denervation, the degeneration contraction occurred between 2 and 3 days later depending on the length of the distal portion of nerve. Cutting the nerve supply 5 cm closer to the muscle in vivo hastened the loss of transmission and the onset of the degeneration contraction by 24-48 hr.7. Supersensitivity to noradrenaline occurred soon after the degeneration contraction but the full development of a sevenfold supersensitivity to noradrenaline, equivalent to that produced by cocaine, took up to 48 hr. No further increase in sensitivity to noradrenaline could be detected in vitro after chronic denervation in vivo for up to 30 days.8. It is concluded that the degeneration contraction and failure of transmission was precipitated by an abrupt increase in the Ca(2+) permeability of the axon causing discharge of transmitter from vesicles. This was probably the result of depletion of essential factors normally transported somatofugally in the axon at 1-2 mm/hr. The supersensitivity to noradrenaline that develops subsequently appears to be due to a loss of the uptake mechanism of the nerve terminals. PMID- 4335915 TI - Oxygen-triggered mouse oocyte maturation in vitro and lactate utilization by mouse oocytes and zygotes. PMID- 4335913 TI - A study of frog muscle maintained in organ culture. AB - 1. Frog muscles are isolated and maintained in organ culture conditions for periods of up to 2 months. During the first 2 weeks, muscle fibres have normal resting membrane and action potentials. Subsequently the potentials decline in amplitude.2. Slow muscle fibres also survive in culture and retain their ability to give maintained contractures.3. Muscle sensory receptors continue to function in culture until the axon terminals degenerate at about 2 weeks.4. Neuromuscular transmission is normal during the first few days of culture, after which the motor endings degenerate. Transmission persists longer (up to 17 days) if a long segment of nerve is left attached to the muscle. With short-nerve preparations failure of transmission in vivo occurs at about the same time as in culture. With long-nerve preparations failure of transmission is delayed even further in culture.5. In short-nerve preparations miniature end-plate potentials disappear, in general, at about the time that transmission fails. In long-nerve preparations some end-plates continue to have miniature end-plate potential activity for a short time after nerve impulses cease to evoke any response; but eventually miniature potential activity disappears from all end-plates.6. After a few days of electrical silence, miniature end-plate potentials reappear at some of the denervated end-plates. The proportion of denervated end-plates which show miniature end-plate potentials in culture is smaller than in muscles denervated in situ.7. Electron microscopy shows that muscle structure is well preserved in culture, that the axons degenerate and that the Schwann cells move to occupy the space vacated by the axons. The Schwann cells are very probably the source of the acetylcholine which evokes miniature potentials in the denervated end-plates. PMID- 4335917 TI - Electron microscopical observations of leaf ferritin from iron-treated Xanthium plants: localization and diversity in the organelle. PMID- 4335916 TI - Ultrastructural changes in the left ventricular rat myocardial cells with age. PMID- 4335918 TI - Pathological studies of Marek's disease. I. The histopathology on field cases in Japan. PMID- 4335919 TI - [Case of unoperable cancer of the rectum in a 14-year-old boy]. PMID- 4335920 TI - [Case of generalized cytomegalia in a newborn]. PMID- 4335921 TI - Tumour-associated antigens and tumour-host interactions. PMID- 4335922 TI - Asexual ateliotic dwarfism (two cases). PMID- 4335923 TI - Plasma angiotension II concentrations and antidiuresis in diabetes insipidus. PMID- 4335924 TI - Angiotensin and thirst. PMID- 4335925 TI - [Results of endolymphatic therapy in malignant lymphomas]. PMID- 4335926 TI - Further studies on the adsorption characteristics of foot-and-mouth disease virus residual to adsorption with homogenized calf kidney. PMID- 4335927 TI - [Post-traumatic headache and neck pain, and pain from pressure on the nerve of Arnold]. PMID- 4335928 TI - [X-ray diagnosis of angiofibroma of the pleura]. PMID- 4335930 TI - Plaque assay for some strains of avian leukosis virus. PMID- 4335929 TI - Protein synthesis in BHK21 cells infected with vesicular stomatitis virus. I. ts Mutants of the Indiana serotype. PMID- 4335931 TI - Competence of suspended HeLa cells for infection by inactivated poliovirus particles and by isolated viral RNA. PMID- 4335932 TI - Ultrastructural changes in KB cultures infected with adenovirus type 2. PMID- 4335934 TI - Restriction of herpes simplex virus replication by poliovirus: a selective inhibition of viral translation. PMID- 4335933 TI - Properties of phage T4 messenger RNA synthesized in the absence of protein synthesis. PMID- 4335935 TI - Studies on the biosynthesis and characterization of rhinovirus ribonucleic acid. PMID- 4335936 TI - Isolation and partial characterization of intracytoplasmic A particles. PMID- 4335937 TI - Some studies on the status of polyoma-specified RNA after transcription. PMID- 4335938 TI - Characterization of broccoli necrotic yellows virus. PMID- 4335939 TI - Evidence for the integration of polyoma virus DNA in a lytic system. PMID- 4335940 TI - Naturally occurring and artificially produced components of three rhinoviruses. PMID- 4335941 TI - The horizontal cells. PMID- 4335942 TI - [Clinical picture of glomus tumor of the middle ear and jugular fossa]. PMID- 4335943 TI - [Detection of unpalpable cancer of the breast]. PMID- 4335944 TI - [Scirrhous adenocarcinoma of the pancreas]. PMID- 4335945 TI - [Incidence and time period of recurrence of rectal cancer after anterior resection]. PMID- 4335946 TI - [Intestinal tumors in rats induced by 1,2-dimethylhydrazine]. PMID- 4335947 TI - [Leukogenic effect of phthalonitrile]. PMID- 4335948 TI - [Serine transoxymethylase activity in the liver of chickens and hamsters with Rous sarcoma]. PMID- 4335949 TI - [Treating patients with peripheral nervous diseases with peat-mud applications and hydrosulfide baths at the Mikulintsy health resort]. PMID- 4335950 TI - [Prevention of dust-induced diseases of the respiratory organs in people engaged in primary flax production]. PMID- 4335951 TI - [Clinical picture and differential diagnosis of influenzal and adenoviral diseases of the nervous system]. PMID- 4335952 TI - [Problems of classification, treatment and prevention of trophoblastic tumors]. PMID- 4335954 TI - An e.p.r. study on the nerves of the frog. PMID- 4335953 TI - Comparative investigations on bone and callus enzymes. PMID- 4335955 TI - The inheritance of familial hypercholesterolemia. PMID- 4335956 TI - Purification and properties of a rabbit kidney fructose diphosphatase with neutral pH optimum. PMID- 4335957 TI - The metabolism of phosphoinositides in rat kidney, in vivo. PMID- 4335958 TI - Stimulation by ACTH analogs of rat adrenal adenyl cyclase activity: correlation with steroidogenic activity. PMID- 4335959 TI - Pseudomonas putida cytochrome P-450: characterization of an oxygenated form of the hemoprotein. PMID- 4335960 TI - Rabbit liver fructose 1,6-diphosphatase. Properties of the native enzyme and their modification by subtilisin. PMID- 4335961 TI - Multiple forms of drosophila alcohol dehydrogenase. 3. Conversion of one form to another by nicotinamide adenine dinucleotide or acetone. PMID- 4335962 TI - Glycolate metabolism in mesophyll cells and bundle sheath cells isolated from crabgrass, Digitaria sanguinalis (L.) Scop., leaves. PMID- 4335963 TI - Multiple forms of drosophila alcohol dehydrogenase. IV. Protein fluorescence studies. PMID- 4335964 TI - The production of lysyl oxidase by human fibroblasts in culture. PMID- 4335965 TI - Metastasis of colon carcinoma to the lip. PMID- 4335966 TI - Adenosine 3':5'-cyclic monophosphate phosphodiesterase in skin. I. Measurement and properties. PMID- 4335967 TI - Adenosine 3':5'-cyclic monophosphate phosphodiesterase in skin. II. Levels in atopic dermatitis. PMID- 4335968 TI - Collagen, collagenase and clinicians. PMID- 4335969 TI - Macular amyloidosis cutis. PMID- 4335970 TI - New thoughts on essential hypertension. PMID- 4335971 TI - Surviral particles in Paget's breast carcinoma. PMID- 4335972 TI - [Ultrastructural differentiation of the trophoblast of human placenta]. PMID- 4335973 TI - [Acino-insular cells of the pancreas in the rat embryo]. PMID- 4335975 TI - [Ultrastructural peculiarities of capillaries during the 1st days of postnatal growth]. PMID- 4335974 TI - [Parafollicular cells of the Wistar rat under the influence of cold]. PMID- 4335976 TI - [Ultrastructure of pacchonian granulations in Cercopithecus callitrichus]. PMID- 4335977 TI - [Vitellogenesis in the ovocyte of the Triturus helveticus Raz. Ultrastructural study]. PMID- 4335978 TI - Treatment of minor salivary gland malignancies of upper food and air passage epithelium. A review of 87 cases. PMID- 4335979 TI - Fibroxanthosarcoma of the soft tissues. A type of malignant fibrous histiocytoma. PMID- 4335980 TI - Renal tubular antigens in kidney tumors. PMID- 4335981 TI - Ultrastructure of tubular carcinoma of the breast. PMID- 4335982 TI - Papillary adenoma of the nipple (florid papillomatosis, adenoma, adenomatosis). A clinicopathologic study. PMID- 4335983 TI - Arthritis in pigs induced by dietary factors. Microbiologic, clinical and histologic studies. PMID- 4335984 TI - Comparative effect of viral and bacterial neuraminidase on the complement sensitivity of lymphoid cells. PMID- 4335985 TI - Quantified human sleep after pentobarbital. PMID- 4335986 TI - An inhibitor present in calf serum which prevents growth of BHK21 cells in suspension culture. PMID- 4335987 TI - Half-lives of enzyme activities in an L5178Y mouse leukaemic cell. PMID- 4335988 TI - Effect of method of cell isolation on the metabolic activity of isolated rat liver cells. PMID- 4335989 TI - A gas chromatographic method for the mycotoxin penicillic acid. PMID- 4335990 TI - Purification and characterization of pesticidal synergists. I. Piperonyl butoxide. PMID- 4335991 TI - Removal of cholesterol from serum extracts of vitamin D by thin-layer chromatography. PMID- 4335993 TI - Cancer of the head and neck. Nasopharyngeal cancer. Pathologic classification and fine structure. PMID- 4335992 TI - The diagnosis of trophoblastic tumours from uterine curettings. AB - The reliability of the diagnosis of choriocarcinoma from uterine curettings is still a matter for debate, and few pathologists see enough material for an objective clinico-pathological study. In the present survey curettings from 54 patients were examined, 38 during follow up of a hydatidiform mole, 12 following a normal pregnancy and four after a spontaneous abortion. Four histological categories were identified: villous, simple trophoblast, trophoblast with appearances suspicious of choriocarcinoma, and trophoblast diagnostic of choriocarcinoma. The presence of hydropic villi is evidence that malignant change has not developed at that time and only two of the 20 patients in this group subsequently developed choriocarcinoma. The interpretation of simple or suspicious trophoblast depends on the antecedent gestation: if it were molar, malignant change is relatively infrequent (choriocarcinoma subsequently developed in four out of 15 patients); if it were non-molar then malignancy is a strong possibility (choriocarcinoma developed in nine and metastatic trophoblastic disease in four of the 13 patients). The correct management of the individual patient can only be achieved by a full consideration of the histological features together with the clinical history and findings. PMID- 4335994 TI - [Mixed tumor of the parotid gland with metastasis to the rib]. PMID- 4335995 TI - [Case of functioning juvenile islet cell carcinoma with atypical symptoms]. PMID- 4335997 TI - The enzyme histochemistry of isoproterenol-induced salivary gland hyperplasia. PMID- 4335996 TI - Cranio-orbital involvement in glioblastoma multiforme. PMID- 4335998 TI - [Therapy of chronic gastritis]. PMID- 4336000 TI - [EEG studies using an electro-acoustic sleep-therapy instrument]. PMID- 4335999 TI - [In 1921, 50 years ago, Otto Loewi proved the existence of chemical mediators of the nervous system]. PMID- 4336001 TI - [Development of therapeutic care in rheumatic diseases and rheumatology]. PMID- 4336002 TI - The influence of LSD on sleep cycles in rats. PMID- 4336003 TI - Individual differences of rats in the first night effect. PMID- 4336004 TI - The analysis of EEG during sleep in sucklings. PMID- 4336005 TI - The influence of stress and ACTH on the protein synthesis in brain. PMID- 4336007 TI - [Time-dependent magnetic changes of aqueous protohemin solutions]. PMID- 4336006 TI - [Experimental testing of some piperidine propanol diastereomers in animals as potential parkinsonism drugs]. PMID- 4336008 TI - [Influence of benzene on the properties of human hemoglobin]. PMID- 4336009 TI - Nocturnal growth hormone secretion: correlation with sleeping EEG in adults and pattern in children and adolescents with non-pituitary dwarfism, overgrowth and with obesity. PMID- 4336010 TI - Fluorometric determination of adenine and its derivatives by reaction with glyoxal hydrate trimer. PMID- 4336011 TI - Convenient method for enzymic synthesis of 14 C-nicotinamide riboside. PMID- 4336013 TI - Analytical measurements of isopycnic density in the preparative ultracentrifuge with application to FeLV and FeLV-RNA. PMID- 4336012 TI - Radioassay for enzymic production of glutamate from glutamine. PMID- 4336014 TI - A new and highly sensitive radiotracer assay for orotate phosphoribosyltransferase. PMID- 4336015 TI - Allergic rhinitis or virus cold? Nasal smear eosinophilia in differential diagnosis. PMID- 4336016 TI - Co-infection of mouse spleen cells with murine sarcoma virus and Guaroa virus. AB - Enhancement of tumor induction by oncornaviruses through a dual viral infection has been described by several investigators. The mechanism(s) of this enhancement has not as yet been determined. By using a murine sarcoma virus and a Bunyawera group arbovirus (Guaroa virus) in an in vitro system, evidence was obtained for enhancement of the oncogenic potential of the viruses by genetic interaction with the nononcogenic virus as well as the production of increased amounts of the oncogenic virus. These results confirm and extend similar responses obtained in in vivo systems. PMID- 4336017 TI - A technique for producing large yields of vegetative cell-free refractile Clostridium perfringens spores of unaltered heat resistance. AB - Sonic treatment of sporulated Clostridium perfringens cultures produced suspensions free of vegetative cells without altering viable spore counts or thermal resistance. PMID- 4336018 TI - Medium-scale production and purification of ochratoxin A, a metabolite of Aspergillus ochraceus. AB - The preparation of crystalline ochratoxin A from Aspergillus ochraceus nutrient solution is described. Methods are adaptable to large-scale fermentations. PMID- 4336020 TI - Hypoglycemia associated with extrapancreatic tumors. Report of two cases with studies on its pathogenesis. PMID- 4336019 TI - Cytomegalovirus infection. PMID- 4336021 TI - Protocollagen proline hydroxylase in isolated rat liver cells. PMID- 4336023 TI - [Attempted quantification of agglutination of transformed cells by concanavalin A]. PMID- 4336022 TI - Renal physiology. PMID- 4336024 TI - Augmented immunogenicity of tumor cell homogenates infected with influenza virus. PMID- 4336025 TI - Respiratory tract carcinogenesis in hamsters induced by different numbers of administrations of benzo(a)pyrene and ferric oxide. PMID- 4336026 TI - Cyclic 3',5'-nucleotide phosphodiesterases of Novikoff rat hepatoma, mouse L, and HeLa cells growing in suspension culture. PMID- 4336027 TI - Increased activity of polynucleotide ligase from rat hepatoma induced by N-2 fluorenylacetamide. PMID- 4336028 TI - The effect of polyinosinic-polycytidylic acid on the immune response of mice to antigenically distinct tumors. PMID- 4336029 TI - Malignant tumors in rats given lasiocarpine. PMID- 4336030 TI - Plasma protein synthesis by N-2-fluorenylacetamide-induced primary hepatocellular carcinomas and hepatic nodules. PMID- 4336031 TI - Studies on nucleoli and cytoplasmic fibrillar bodies of human hepatocellular carcinomas. PMID- 4336032 TI - Lymphocyte blastogenic responses to cultured allogeneic tumor cells in vitro. PMID- 4336033 TI - Pharmacologic effects on developing enzyme systems. PMID- 4336034 TI - Antigenicity of "smooth" and "rough" membrane subfractions of mouse thymus and spleen estimated by the migration inhibition test (electronmicroscopy-enzyme markers-skin grafts-lyophilization). PMID- 4336035 TI - Psychopharmacological influence on day sleep after night shift. PMID- 4336037 TI - [Biological features of strains of Cl. perfringens isolated during toxinfections]. PMID- 4336036 TI - Circadian rhythms in adrenal organ cultures. PMID- 4336038 TI - Survival of BCG in rat tissues. PMID- 4336040 TI - Enzymatic synthesis of deoxyribonucleic acid. 36. A proofreading function for the 3' leads to 5' exonuclease activity in deoxyribonucleic acid polymerases. PMID- 4336039 TI - Cyclic nucleotide-dependent protein kinases. X. An assay method for the measurement of quanosine 3',5'-monophosphate in various biological materials and a study of agents regulating its levels in heart and brain. PMID- 4336042 TI - Horse liver aldehyde dehydrogenase. II. Kinetics and mechanistic implications of the dehydrogenase and esterase activity. PMID- 4336041 TI - Horse liver aldehyde dehydrogenase. I. Purification and characterization. PMID- 4336043 TI - Molecular forms and subunit composition of a cyclic adenosine 3',5'-monophosphate dependent protein kinase purified from bovine heart muscle. PMID- 4336044 TI - Anion binding to bovine erythrocyte superoxide dismutase. Evidence for multiple binding sites with qualitatively different properties. PMID- 4336045 TI - Ultrastructure of a Wilms' tumour and myogenesis. PMID- 4336046 TI - Crystalline strucutes in lymphocytes. PMID- 4336047 TI - Release of endogenous noradrenaline from an isolated muscular artery. Release of endogenous noradrenaline from an isolated muscular artery. AB - 1. The release of noradrenaline by field stimulation of vasoconstrictor nerves has been studied in isolated preparations of the main uterine artery of the guinea-pig.2. In preparations from virgin animals stimulation with trains of 3000 square pulses at 5 and 25 pulses/sec resulted in mean overflows of 0.56 ng/g.pulse and 1.53 ng/g.pulse respectively.3. Inhibition of monoamine oxidase and catechol-O-methyltransferase had no consistent effect on overflow at either stimulation frequency.4. Desmethylimipramine (10(-5)M) caused, on the average, a 2.4-fold increase in overflow following stimulation at 5 pulses/sec while phenoxybenzamine (10(-5)M) caused a 3.8-fold increase. Neither of these drugs caused a significant alteration of the overflow during stimulation at 25 pulses/sec.5. Treatment of the tissues with desmethylimipramine plus normetanephrine (4.5 x 10(-4)M) caused no more increase in overflow than treatment with desmethylimipramine alone.6. It is concluded that enzymatic metabolism of noradrenaline at the synapse is of little functional importance in this tissue, and that the most important mechanism of transmitter inactivation is by nervous re-uptake. Although phenoxybenzamine was more effective than desmethylimipramine in increasing transmitter overflow, no evidence was obtained to support the view that this effectiveness was due partly to blockade of ;Uptake 2'.7. There was sometimes very low overflow of noradrenaline from arteries taken from animals in the last week of pregnancy. In these instances overflow following stimulation at 5 pulses/sec was not increased by phenoxybenzamine treatment of the tissue.8. Methylene blue and fluorescence microscopic techniques indicated that the terminal adrenergic axons in each artery possess approximately 8.74 x 10(5) varicosities. The mean tissue content of noradrenaline was found to be 9.6 mug/g or 29 ng/artery. These results have been correlated with known morphological and electrophysiological data to derive a peak post-junctional concentration of noradrenaline during transmission of about 4 x 10(-4)M.9. The fraction of total noradrenaline content of the artery released per pulse (under the influence of phenoxybenzamine) had a mean value of 2.2 x 10(-4). PMID- 4336049 TI - [Determination of lactate dehydrogenase (LDH) isoenzymes]. PMID- 4336048 TI - Spinal integration of segmental, cortical and breathing inputs to thoracic respiratory motoneurones. AB - 1. The spinal integration of cortical, segmental and breathing inputs to thoracic motoneurones was studied in anaesthetized, paralysed cats: the breathing input was intensified by underventilation or abolished by hyperventilation.2. In apnoeic animals, low intensity stimulation of an internal intercostal nerve evoked a brief latency polysynaptic reflex discharge of expiratory motoneurones (direct response) in several adjacent segments with no or little response of the inspiratory motoneurones.3. A similar direct response of expiratory motoneurones occurred with brief tetanic stimulation of the trunk area in the contralateral sensorimotor cortex.4. Conditioning of an intercostal-intercostal test reflex by a prior stimulus to an intercostal nerve or to the cortex gave conditioning curves showing facilitation of transmission to expiratory motoneurones at short intervals (5-25 msec) and inhibition at long intervals (25-200 msec).5. The direct response of expiratory motoneurones to the cortical or segmental inputs was depressed during the inspiratory phase when the animal was underventilated; conversely the spontaneous activity of the inspiratory motoneurones was inhibited for a period that corresponded with the direct response or to the phase of facilitated transmission to expiratory motoneurones. During the expiratory phase, the cortically or segmentally induced direct response was facilitated but the inhibition of inspiratory motoneurone activity was concealed by the absence of spontaneous activity.6. It was possible with discrete lesions of the spinal cord to differentiate between the pathways subserving the responses to cortical stimulation and the spontaneous activity due to the breathing input.7. To account for the results a working hypothesis is proposed utilizing a segmental interneuronal network which transmits mutual reciprocal inhibition between inspiratory and expiratory motoneurones. PMID- 4336050 TI - Pathological studies of Marek's disease. II. Electron microscopic observation of the cellular lesions in the peripheral nerves. PMID- 4336052 TI - [Recurrent gastrointestinal hemorrhages associated with hiatal hernia]. PMID- 4336051 TI - [Polymorphism of erythrocyte enzyme activities on a genetic basis (collective review)]. PMID- 4336053 TI - [Cyclic AMP]. PMID- 4336054 TI - Establishment, viral susceptibility and biological characteristics of a swine kidney cell line SK-6. PMID- 4336055 TI - Failure of the scrapie agent to replicate in L5178Y mouse leukaemic cells. PMID- 4336056 TI - Neutralizing activity of sera from guinea-pigs inoculated with foot-and-mouth disease virus variants. PMID- 4336057 TI - Bacterial plasmids instrumental in the origin of eukaryotes? PMID- 4336058 TI - Dissociation constant of angiotensin II as determined by the use of an irreversible specific inhibitor (1-Sar-8-Leu-AT II ). PMID- 4336060 TI - Studies on parainfluenza virus pneumonia in children. 1. Factors in the determination of hemagglutination--inhibition antibody against parainfluenza viruses. PMID- 4336059 TI - [Diagnosis and differential diagnosis of coronary blood flow disorders]. PMID- 4336061 TI - Studies on parainfluenza virus pneumonia in children. 2. Parainfluenza virus pneumonia found in the mass chest x-ray surveys in children. PMID- 4336062 TI - Steroid production by gonadal tumors in male pseudo-hermaphroditism with isolated clitoromegaly. Biochemical studies in vivo. PMID- 4336063 TI - [A simple column chromatographic method of the simultaneous determination of pregnanediol, pregnanetriol and total 17-hydroxycorticosteroids in urine]. PMID- 4336065 TI - Histochemical evidence of cell death in transplanted tumours. PMID- 4336064 TI - [Lysosomal glycogen breakdown and hepatocellular glycogen metabolism. Cellular autophagy induced by intraperitoneal injection of hypertonic solution of glucose]. PMID- 4336066 TI - Membrane-particle complexes in cultured mouse foot pad cells exposed to Mycobacterium thamnopheos. PMID- 4336067 TI - The genesis of apudamyloid in endocrine polypeptide tumours: histochemical distinction from immunamyloid. PMID- 4336068 TI - [Role of cytologic studies in the diagnosis of thyroid neoplasms]. PMID- 4336069 TI - [Means of improving the diagnosis of malignant neoplasms of the soft tissues]. PMID- 4336070 TI - [Absorption of Rous virus by naturally resistant cells (electron microscopic study)]. PMID- 4336071 TI - [Neoplasms in gray hamsters induced by Rous sarcoma virus]. PMID- 4336072 TI - [Effect of nas on the liver in Syrian hamsters]. PMID- 4336073 TI - Formation of the vitelline membrane and chorion in developing oocytes of Ephestia kuhniella. PMID- 4336074 TI - [Effect of 6-hydroxydopamine on the catecholamine content of the rat carotid body]. PMID- 4336075 TI - [Structure of the corpora pedunculata in the insect brain. II. Synaptic connections in the alpha lobe of the cricket Acheta domesticus L]. PMID- 4336076 TI - [Autophagy in gastric gland cells of young mice]. PMID- 4336078 TI - Additive toxicity of vincristine and other drugs for the peripheral nervous system. Three case reports. PMID- 4336077 TI - [Pinocytosis and locomotion of amoebae. VII. Quantitative studies on membrane turnover in Hyalodiscus simplex]. PMID- 4336079 TI - [Viomycin sorption. Sorption of viomycin in the presence of inorganic cations on carboxylic cation exchanger Wofatyt CP in sodium and hydrogen-sodium]. PMID- 4336080 TI - Decreased resistance against infectious canine hepatitis in dogs fed a high-fat ration. PMID- 4336081 TI - Response of calves to parainfluenza-3 vaccines administered nasally or parenterally. PMID- 4336082 TI - Foot-and-mouth disease vaccine: influence of the vaccine virus subtype on neutralizing antibody and resistance to disease. PMID- 4336083 TI - Comparison of antiserums produced in chickens, rabbits, and specific-pathogen free pigs for the typing of porcine enteroviruses. PMID- 4336085 TI - Virus-like particles associated with myocarditis of turkeys. PMID- 4336084 TI - Pathogenesis of experimentally produced mouse adenovirus infection in mice. PMID- 4336086 TI - Applications of microspectofluorometry in quantitation of immunofluorescence on single cells. PMID- 4336087 TI - [Studies on the chemical composition of the arterial wall. X. Studies of the dynamics of ACTH on mucopolysaccharides of arterial wall]. PMID- 4336088 TI - [Histochemical examinations of the para-parotid Loewenthal's gland in the white rat during gestation]. PMID- 4336089 TI - Synaptic organization of commissural projections of the hippocampal region in the guinea pig. II. Dorsal psalterium: pre-hippocampal and intrahippocampal relays. PMID- 4336090 TI - [Cell surface of vascular endothelium and its role in trans-capillary exchange mechanisms]. PMID- 4336091 TI - [Current concepts on the ultrastructure of the capillary wall]. PMID- 4336092 TI - Solubility and dialysis limits of DNA oligonucleotides. PMID- 4336093 TI - Indospicine as an arginine antagonist in Escherichia coli and Pseudomonas aeruginosa. PMID- 4336094 TI - Influence of 2'-O-acetylation on the antiviral activity of polyribonucleotides. PMID- 4336095 TI - [Location of polyphosphatases, hydrolyzing polyphosphates to orthophosphates, in the subcellular structures of Neurospora crassa]. PMID- 4336096 TI - [Purification and various properties of Clostridium welchii SR-12 glutaminase]. PMID- 4336097 TI - [Distribution of malate- and NADH-dehydrogenases and other proteins following fragmentation of Micrococcus lysodeikticus membranes]. PMID- 4336098 TI - Factors affecting the retention of calcium by the chick. PMID- 4336099 TI - [Regulation of monoamine oxidase activity by glucocorticoids]. PMID- 4336100 TI - [Origin of the form of potentials recorded by a surface electrode placed on an entire nerve]. PMID- 4336101 TI - [Action of vitamin A on the transformation in vitro of 16 hydroxydehydroepiandrosterone into 16 hydroxyandrostenedione by the placental tissue]. PMID- 4336102 TI - [Determination of the number of cellular sites binding concanavalin A, using a consumption test]. PMID- 4336105 TI - [Clinical aspects, epidemiological and serological studies on epidemic mumps in a day nursery. A contribution on the question of clinically inapparent mumps]. PMID- 4336106 TI - A method for the separation of fiber types from skeletal muscle. PMID- 4336103 TI - Hormonal steroid contraceptives. IV. Adverse reactions and management of the patient. PMID- 4336104 TI - Diazoxide: a review of its pharmacological properties and therapeutic use in hypertensive crises. PMID- 4336107 TI - Identification of products of the uridinediphospho-N-acetyl-D-glucosamine oxidoreductase system from Citrobacter freundii ATCC 10053. AB - Uridinediphospho-N-acetyl glucosamine is converted to one or more uridine diphospho-4-keto-6-deoxy-2-acetamidohexose derivatives by an enzyme from Citrobacter freundii ATCC 10053. Borohydride reduction of reaction products followed by acid hydrolysis yielded several amino sugars. Two of these were identified as fucosamine and quinovosamine by chromatography and ninhydrin degradation. PMID- 4336108 TI - cis-terpin hydrate metabolism by a Brevibacterium: patterns of enzyme induction, and accumulation of -terpineol in growth. AB - A brevibacterium, strain TH-4, previously isolated by aerobic enrichment on the monocyclic monoterpenoid cis-terpin hydrate as a sole carbon and energy source, was found to grow on alpha-terpineol and on a number of common sugars and organic acids. Oxidation of these terpenoids was shown to occur via an induced enzyme system, as measured manometrically by oxygen uptake and prevention of protein synthesis with chloramphenicol or puromycin. Oxidation of terpin hydrate by cell suspensions appeared to be coincidentally induced by growth on alpha-terpineol, and oxidation of alpha-terpineol similarly appeared to be induced by growth on terpin hydrate. Culture fluids in which the TH-4 organism was grown at the expense of cis-terpin hydrate were found to contain (-)-alpha-terpineol in combined butanol-ether extracts. The isolated compound was shown to be chromatographically and spectrophotometrically identical to an authentic sample of alpha-terpineol. The stereospecificity of an enzymatic dehydration of terpin hydrate to alpha-terpineol is considered. PMID- 4336109 TI - Isolation and characterization of Microsporum gypseum lysosomes: role of lysosomes in macroconidia germination. AB - Three types of lysosomes containing either acid protease, alkaline protease, or phosphodiesterase were isolated from a Microsporum gypseum macroconidial homogenate on Ficoll gradients. The acid protease was contained in an assimilative lysosome since its activity was affected by the complexity of the exogenous nitrogen source. Ultracentrifugation and electron microscopy revealed that the alkaline protease-containing vesicles were associated with the spore coat material prior to macroconidial germination. During macroconidial germination, zones of spore coat hydrolysis were seen surrounding these vesicles. Other larger vesicles, believed to contain the phosphodiesterase, were also observed in the spore coat during macroconidial germination. PMID- 4336110 TI - Sporulation and enterotoxin production by mutants of Clostridium perfringens. AB - The ability of Clostridium perfringens type A to produce an enterotoxin active in human food poisoning has been shown to be directly related to the ability of the organism to sporulate. Enterotoxin was produced only in a sporulation medium and not in a growth medium in which sporulation was repressed. Mutants with an altered ability to sporulate were isolated from an sp(+) ent(+) strain either as spontaneous mutants or after mutagenesis with acridine orange or nitrosoguanidine. All sp(0) (-) mutants were ent(-). Except for one isolate, these mutants were not disturbed in other toxic functions characteristic of the wild type and unrelated to sporulation. A total of four of seven osp(0) mutants retained the ability to produce detectable levels of enterotoxin. None of the ent(-) mutants produced gene products serologically homologous to enterotoxin. A total of three sp(-) mutants, blocked at intermediate stages of sporulation, produced enterotoxin. Of these mutants, one was blocked at stage III, one probably at late stage IV, and one probably at stage V. A total of three sp(+) revertants isolated from an sp(-) ent(-) mutant regained not only the ability to sporulate but also the ability to produce enterotoxin. The enterotoxin appears to be a sporulation-specific gene product; however, the function of the enterotoxin in sporulation is unknown. PMID- 4336111 TI - Electron transport systems of Nitrosomonas: isolation of a membrane-envelope fraction. AB - Freezing and thawing of Nitrosomonas, followed by centrifugation of the homogenate at 3,000 x g, resulted in a fraction which appeared to consist of an intact membrane-envelope complex and contained approximately 50% of the cell protein and more than 90% of the ubiquinone and cytochrome A-type mammalian cytochrome c oxidase activity. The supernatant fraction, resulting from subsequent centrifugation of the extract at 100,000 x g, contained approximately 50% of the cell protein and more than 80% of the B- and C-type cytochrome and P 463 and the enzymes glutamate dehydrogenase; hydroxylamine dehydrogenase; nitrite synthetase; nitrite reductase; and 2,6-dichlorophenolindophenol-, p phenylenediamine-, pyrogallol-, and hydroquinone-oxidase. Data on the concentration of electron transport components in Nitrosomonas are presented. PMID- 4336113 TI - Biochemical and structural variations in the flight muscle mitochondria of ageing blowflies, Calliphora erythrocephala. PMID- 4336112 TI - Specific repression of phosphoribosylpyrophosphate synthetase by uridine compounds in Salmonella typhimurium. AB - Mutants of Salmonella typhimurium with specific pyrimidine requirements were used to demonstrate that only uridine compounds exert repressive control over synthesis of phosphoribosylpyrophosphate synthetase. PMID- 4336114 TI - Premature chromosome condensation: a mechanism for the elimination of chromosomes in virus-fused cells. PMID- 4336115 TI - Foot-and-mouth disease and the African buffalo (Syncerus caffer). PMID- 4336116 TI - Pathogenicity for cattle of Allerton-type herpesvirus isolated from a Tanzanian Buffalo (Syncerus caffer). PMID- 4336117 TI - The effects of hypophysectomy on the metabolism of adrenal steroids in the pigeon (Columba livia). PMID- 4336118 TI - The development of a radioimmunoassay for bovine neurophysin. PMID- 4336119 TI - The effect of metyrapone on corticotrophin secretion. PMID- 4336120 TI - Corticotrophin-induced differentiation of mitochondria in rat adrenal cortical cells grown in primary tissue culture: effects of ethidium bromide. PMID- 4336121 TI - The chemical composition of flushings from rat uteri with and without intra uterine devices. PMID- 4336122 TI - Cyclic AMP and hormone action. PMID- 4336124 TI - [Central dizziness and peripheral vertigo]. PMID- 4336123 TI - Granulation tissue as a contractile organ. A study of structure and function. AB - CONTRACTING GRANULATION TISSUES CONTAIN FIBROBLASTS THAT DEVELOP CHARACTERISTICS TYPICAL OF SMOOTH MUSCLE: (a) They contain an extensive cytoplasmic fibrillar system. (b) They show immunofluorescent labeling of their cytoplasm with human anti-smooth muscle serum. (c) The nuclei show complicated folds and indentations, indicative of cellular contraction. (d) There are cell-to-cell and cell-to-stroma attachments. (e) It is possible to extract similar quantities of actomyosin (having the same adenosine triphosphatase activity) from granulation tissue and from pregnant rat uterus. (f) Strips of granulation tissue, when tested pharmacologically in vitro, behave similarly to smooth muscle. All these data support the view that, under certain conditions, fibroblasts can differentiate into a cell type structurally and functionally similar to smooth muscle and that this cell, the "myo-fibroblast," plays an important role in connective tissue contraction. PMID- 4336126 TI - Entrapment neuropathy of radial nerve: a review of 4 cases. PMID- 4336125 TI - [Role of radiation treatment in cylindroma of the salivary glands]. PMID- 4336127 TI - Experimental induction of placental tumor in the guinea pig. PMID- 4336128 TI - [Polyneuropathy developing during vinblastine treatment for Hodgkin's disease]. PMID- 4336129 TI - [Electromyographic findings in cases of peripheral nerve lesions]. PMID- 4336130 TI - [Differential diagnosis of central and peripheral facial nerve palsy in children]. PMID- 4336131 TI - [Early and late results of treatment of supratentorial gliomas]. PMID- 4336132 TI - [Malignant islet cell tumor of the pancreas]. PMID- 4336133 TI - [Effects on health of atmospheric pollution with asbestos or other fibrous particles]. PMID- 4336134 TI - A preliminary report on the possible biosynthesis in vitro of estrogen phosphates by liver, ovary and uterus of adult rabbits. PMID- 4336135 TI - Pathological changes in the brain associated with fits in dogs. PMID- 4336137 TI - Crystalline bodies in parathyroid gland cells of Rana temporaria L. PMID- 4336136 TI - [Fine structure of the merozoites of Babesia ovis in the salivary glands of female ticks]. PMID- 4336138 TI - [Fine structure of the labial cephalic kidney of Campodea chardardi Conde (Diplura, Insecta)]. PMID- 4336140 TI - [Radiographic measurement of the fetal length]. PMID- 4336139 TI - [Structural changes of the salivary gland in Drosophila melanogaster larvae. Contribution concerning the problem of the influence of active genes on the cytoplasm]. PMID- 4336142 TI - [Preparation and chemical characteristics of an agglutinogen with properties of factor 3]. PMID- 4336141 TI - [Studies on tissue reaction and tolerance in hysterosalpingography]. PMID- 4336143 TI - [STudy of the arginine deiminase system of Cl. perfringens]. PMID- 4336144 TI - [Origin of antibodies of different specificity in the sera of premature infants in the 1st weeks of life]. PMID- 4336145 TI - Effect of tri-O-cresyl phosphate (TOCP) poisoning on sensory nerve terminations of slow loris (Nycticebus coucang coucang). PMID- 4336147 TI - Further trials of metronidazole in amoebic dysentery and amoebic liver abscess. PMID- 4336146 TI - [Atypical mitoses in human brain tumours (medulloblastoma, glioblastoma)]. PMID- 4336148 TI - Penetrating grafts using herpes convalescent cornea. PMID- 4336149 TI - Facial nerve paralysis. A criterion of malignancy in parotid tumors. PMID- 4336150 TI - Experimental facial nerve paralysis. PMID- 4336151 TI - Experimental facial nerve paralysis. An evaluation of surgical and medical therapy. PMID- 4336153 TI - [Virus-like inclusions in chronic neuromuscular disorders. Electronmicroscopic findings of 2 cases]. PMID- 4336152 TI - Varicella-Zoster virus in idiopathic facial palsy. PMID- 4336154 TI - [A hypothesis for the physiological basis of size perception: a study of information transmission for length and orientation with endpoints and lines]. PMID- 4336155 TI - Structure-activity relationship of synthetic corticotrophin peptides. PMID- 4336156 TI - 1-24-adrenocorticotrophin diazotized to polyacrylamide: effects on isolated adrenal cells. PMID- 4336157 TI - Effect of vasopressin on the uptake of calcium ions by kidney mitochondria and on the concentration of adenosine 3':5'-cyclic monophosphate in toad bladder. PMID- 4336158 TI - Poly(adenosine diphosphate ribose) polymerase in Physarum polycephalum nuclei. PMID- 4336159 TI - Factors regulating L-alanine-glyoxylate aminotransferase development in neonatal rat liver. PMID- 4336160 TI - The complete hydrolysis of peptides by a mixture of sepharose-bound peptidases. PMID- 4336161 TI - Mossbauer studies of adrenodoxin. The mechanism of electron transfer in a hydroxylase iron-sulphur protein. AB - 1. Mossbauer spectra were measured of adrenodoxin purified from porcine adrenal glands. They show similarities to the spectra of the plant ferredoxins. All of these proteins contain two atoms of iron and two of inorganic sulphide per molecule, and on reduction accept one electron. 2. As with the plant ferredoxins the adrenodoxin for these measurements was enriched with (57)Fe by reconstitution of the apo-protein, and subsequently was carefully purified and checked by a number of methods to ensure that it was in the same conformation as the native protein and contained no extraneous iron. 3. The Mossbauer spectra of oxidized adrenodoxin at temperatures from 4.2 degrees K to 197 degrees K show that the iron atoms are probably high-spin Fe(3+), and in similar environments, and experience little or no magnetic field from the electrons. 4. Mossbauer spectra of reduced adrenodoxin showed magnetic hyperfine structure at all temperatures from 1.7 degrees K to 244 degrees K, in contrast with the reduced plant ferredoxins, which showed it only at lower temperatures. This is a consequence of a longer electron-spin relaxation time in reduced adrenodoxin. 5. At 4.2 degrees K in a small magnetic field the spectrum of reduced adrenodoxin shows a sixline Zeeman pattern due to Fe(3+) superimposed upon a combined magnetic and quadrupole spectrum due to Fe(2+). 6. In a large magnetic field (30kG) each hyperfine pattern is further split into two. Analysis of these spectra at 4.2 degrees K and 1.7 degrees K shows that the effective fields at the Fe(3+) and Fe(2+) nuclei are in opposite directions. This agrees with the proposal, first made for the ferredoxins, that the iron atoms are antiferromagnetically coupled. 7. In accord with the model for the ferredoxins, it is proposed that the oxidized adrenodoxin contains two high-spin Fe(3+) atoms which are antiferromagnetically coupled; on reduction one iron atom becomes high-spin Fe(2+). PMID- 4336162 TI - Deiodination of L-thyroxine and its activity on the oxidation in vitro of reduced nicotinamide-adenine dinucleotide by peroxidase plus hydrogen peroxide. AB - When l-thyroxine activates the oxidation of NADH by peroxidase+H(2)O(2), little removal of phenolic-ring iodine atoms becomes apparent until most of the NADH has been oxidized, after which it increases markedly. This extensive deiodination is accompanied by loss of the ability of thyroxine to catalyse the oxidation of NADH by peroxidase+H(2)O(2). The slight deiodination observed before the appearance of extensive deiodination is somewhat higher when the effect of thyroxine on NADH oxidation is greater, and lower when thyroxine has exerted a slighter effect. ICN (but not I(2) or thyronine) catalyses NADH oxidation, in both the presence and the absence of peroxidase+H(2)O(2): thyroxine+peroxidase+H(2)O(2) are thus comparable with ICN alone in their effects on NADH oxidation. The obvious conclusion from the above observation, namely that the active moiety is the halogen liberated from thyroxine (or ICN) is, however, not directly supported by some of the results obtained by measuring the degree of deiodination of thyroxine in the system. In an attempt to reconcile some apparently contradictory conclusions, it is suggested that, when thyroxine activates oxidation of NADH by peroxidase+H(2)O(2), the diphenyl ether structure is undergoing cyclic deiodination and iodination. This would be accompanied by the maintenance in the reaction medium of an oxidized form of iodine, similar to that liberated by ICN, which would be the actual active moiety, until the NADH concentration becomes so low that the diphenyl ether structure is ruptured oxidatively. An alternative explanation is that thyroxine is oxidized to a form that either oxidizes NADH or loses iodine in competing reactions. PMID- 4336163 TI - Metabolism of [8-L-[14C] phenylalanine]-angiotensin I in the pulmonary circulation. PMID- 4336164 TI - Isolation and some properties of ribonuclease from Fusarium moniliforme. PMID- 4336165 TI - Steric, chiral and conformational aspects of the 3-hydroxy- and 20-hydroxysteroid dehydrogenase activities of cortisone reductase preparations. PMID- 4336166 TI - Effect of fluoride on liver phosphorylase phosphatase. PMID- 4336167 TI - Purification and properties of cyclic AMP phosphodiesterase from rat brain. PMID- 4336168 TI - Common properties of D-glucuronolactone and aldehyde dehydrogenase from the soluble fraction of rat liver. PMID- 4336169 TI - Kinetic studies with muscle acylphosphatase. PMID- 4336170 TI - Regulation of microsomal enzymes by phospholipids. IV. Species differences in the properties of microsomal UDP-glucuronyltransferase. PMID- 4336171 TI - Kinetic studies of inhibition of adenine phosphoribosyltransferase by guanylate. PMID- 4336172 TI - Adenosine 3':5'-monophosphate dependent protein kinase in the lacrymal gland. PMID- 4336173 TI - Neuroclinical-pathology conference. Progressive central nervous system disease in the course of chronic myelocytic leukemia. PMID- 4336174 TI - [Variation of free nucleotide and phosphocreatine levels in brains of sensitive mice during audiogenic seizures]. PMID- 4336175 TI - [Formation of vitelline plaquettes without intervention of cytoplasmic organelles in the ovocyte of Triturus marmoratus Latr]. PMID- 4336176 TI - [Loss of cellular sensitivity to endogenous interferon induced with the murine sarcoma virus]. PMID- 4336178 TI - Mural and valvular endocarditis of mice infected with encephalomyocarditis (EMC) virus. PMID- 4336179 TI - Further studies of the viruses of the chimpanzee. 3. Infection and excretion patterns in imported chimpanzees. PMID- 4336177 TI - Initial dentin formation in human deciduous teeth. An electron microscope study. PMID- 4336180 TI - [Myelographic differential diagnosis of intramedullary space requiring processes]. PMID- 4336181 TI - [Radicular and subdural cysts in the peridurographic picture]. PMID- 4336182 TI - [Use and significance of technical diagnostic methods in the examination of intracranial tumors in infancy]. PMID- 4336183 TI - [Differential diagnosis brain neoplasms--brain infarct. Angiographic problems in the differentiation of a cerebro-vascular attack due to an intracranial tumor]. PMID- 4336184 TI - [Diagnostic significance of brain scanning]. PMID- 4336185 TI - [Scanning in comparison with angiography and encephalography in brain tumors]. PMID- 4336186 TI - [Diagnosis of Lindau's tumors in retrograde brachial angiography]. PMID- 4336187 TI - [Influence of hydrocephalic increase of intracranial pressure on structure and growth of the infantile skull]. PMID- 4336188 TI - [Radiographic panoramic demonstration of the middle face using central focus]. PMID- 4336189 TI - [Physical stress and spondylosis deformans]. PMID- 4336191 TI - [Metaphysial dysplasia--Pyle's disease]. PMID- 4336190 TI - [A case for diagnosis. (Bone tuberculosis? BCG sarcoidosis? Rheumatoid arthritis? Cryptogenic osteolysis? Mucopolysaccharidosis?)]. PMID- 4336192 TI - [Dorsal contrast media leak in ankle joint arthrography]. PMID- 4336194 TI - [Lymphographic studies on recurring erysipelas]. PMID- 4336193 TI - [Rare lymphographic findings in a mixed angiodysplasia]. PMID- 4336195 TI - [Clinical and therapeutical problems in metastases of the cervical lymph nodes]. PMID- 4336197 TI - [Unusual big hour-glass neurinoma]. PMID- 4336196 TI - [Picture construction in tomography using uni- and multidimensional blurring]. PMID- 4336198 TI - [Hemispheric angioma in childhood]. PMID- 4336199 TI - [Localised Pierre Marie-Bamberger paraneoplastic pneumonic hypertrohpic osteoarthropathy]. PMID- 4336200 TI - [Diagnosis of cervix carcinoma using hysterography]. PMID- 4336202 TI - Simian Virus Reference Center. PMID- 4336203 TI - A striking therapeutic result. A case report of poison ivy. PMID- 4336201 TI - Infectious mononucleosis: appearance of neutralizing antibody to Epstein-Barr virus measured by inhibition of formation of lymphoblastoid cell lines. PMID- 4336205 TI - [Determination of lymphocytosis-promoting factor]. PMID- 4336204 TI - Beta cell adenoma in a child with hypoglycemia controlled with diazoxide. PMID- 4336206 TI - [Megagrisevit for treatment of multiple sclerosis]. PMID- 4336207 TI - [Congenital aplastic anemia of the Joseph-Diamond-Blakfan type. Case report]. PMID- 4336208 TI - Metabolic regulation in plants. PMID- 4336209 TI - Specific origin in SV40 DNA replication. PMID- 4336210 TI - Schistosoma mansoni: in vitro transformation of cercariae into schistosomula. PMID- 4336211 TI - Biochemical and histochemical studies on the non-specific phosphomonoesterases of Fasciola gigantica Cobbold 1855. PMID- 4336212 TI - Cell coat, worm-like structures, and labyrinths in guinea pig resident and exudate peritoneal macrophages, as demonstrated by an abbreviated fixation procedure for electron microscopy. PMID- 4336213 TI - Ultrastructure of the hypodermis during cuticle formation in the third molt of the nematode Nippostrongylus brasiliensis. PMID- 4336214 TI - Cytodifferentiation in the Rana pipiens oocyte. IV. Ultrastructural localization of thiamine pyrophosphatase and horseradish peroxidase. PMID- 4336215 TI - Ultrastructure of sympathetic ganglion cells and granule-containing cells in the paracervical (Frankenhauser) ganglion of the newborn rat. PMID- 4336216 TI - [Ultrastructural study and development of the neuroepithelial cells of regenerating epidermic arm cells in Asterina gibbosa Penn]. PMID- 4336217 TI - Electron microscopy of severed motor fibers in the crayfish. PMID- 4336218 TI - Quantitative electron microscopic autoradiography on the mouse thyroid gland after administration of 3 H-L-DOPA. PMID- 4336219 TI - [The forms of synapses and the occurrence of acetylcholinesterase in the pineal organ of Bombina variegata (L.), (Anura)]. PMID- 4336220 TI - II. Ultrastructure of duct cell granules in mammalian submaxillary glands. PMID- 4336221 TI - Ultrastructural localization of monoamines in the central nervous system of Lumbricus terrestris (L.) with remarks on neurosecretory vesicles. PMID- 4336222 TI - [Mucinous adenocarcinoma in diverticulum of the bladder in female]. PMID- 4336223 TI - [Sarcoma of the prostate with extensive metastases: report of a case]. PMID- 4336224 TI - Sleep-wake cycle of an unrestrained isolated chimpanzee under entrained and free running conditions. PMID- 4336225 TI - Influence of exposure to compulsive locomotion and of hyperbaric oxygenation to gamma-aminobutyric acid levels in mice. PMID- 4336226 TI - The mode of action of hormones. PMID- 4336227 TI - Lack of significant oncogenicity of biological products in hamsters. AB - A variety of biological products which included live and inactivated viral vaccines, inactivated rickettsial and bacterial vaccines, toxoids, and a multiple bacterial antigen product did not appear to be oncogenic for newborn hamsters following a single subcutaneous inoculation. The incidence of spontaneous tumors was approximately 4.7%, and this figure was not significantly altered by the inoculation of any of the test materials. PMID- 4336228 TI - Coagulase and deoxyribonuclease activities of staphylococci isolated from clinical sources. AB - A total of 504 clinical isolates of the family Micrococcaceae were tested for coagulase, deoxyribonuclease, clumping factor, and phosphatase to determine whether there is a correlation between the results of these tests and the pathogenicity of staphylococci. In the tests for coagulase production, it was found that either human or rabbit plasma could be used with broth cultures, whereas rabbit but not human plasma was satisfactory when microorganisms removed from solid culture medium were used. Deoxyribonuclease production correlated better than the fermentation of mannitol with coagulase production. The use of methyl green, Toluidine Blue O, or acridine orange offered no advantage over the use of HCl for detecting the production of deoxyribonuclease. Neither the presence of clumping factor nor the production of phosphatase correlated well with coagulase production. Strains of staphylococci that did not produce coagulase and deoxyribonuclease were isolated as frequently as, and from a greater variety of clinical sources than, strains which produced these substances. It is concluded that the production of coagulase and deoxyribonuclease are properties of staphylococci which are not necessarily indicative of potential pathogenicity of the organisms for man. PMID- 4336230 TI - Pediatric electrodiagnosis. PMID- 4336229 TI - Microculture plaque assay for human and simian cytomegaloviruses. AB - The plaque assay for human and simian cytomegaloviruses routinely carried out in 60-mm petri dishes (macrocultures) has been adapted for use in microcultures in flat-bottom 16-mm circular wells of disposable plastic trays. Virus titrations and serum neutralization assays carried out in microcultures yielded reproducible results that were identical to those obtained in macrocultures. PMID- 4336231 TI - Adrenal response to tetracosactrin in newborn infants. PMID- 4336232 TI - Ketosis in hepatic glycogenosis. PMID- 4336234 TI - Functional tests of adrenal axis in children with measurement of plasma cortisol by competitive protein binding. PMID- 4336233 TI - Diagnosis of congenital adrenal hyperplasia by measurement of plasma 17 hydroxyprogesterone. PMID- 4336235 TI - The b-type cytochromes of beef heart mitochondria. PMID- 4336237 TI - [Determination of the plasma renin activity by micromethod in the peripheral blood in man]. PMID- 4336236 TI - Effects of amphetamine, chlorpromazine and reserpine on cyclic GMP and cyclic AMP levels in mouse cerebellum. PMID- 4336238 TI - Interferon inhibition of DNA synthesis and cell division. PMID- 4336239 TI - Fine structure of the thermophilic blue-green alga Synechococcus lividus Copeland. A study of frozen-fractured-etched cells. PMID- 4336240 TI - Properties of polyoma virus-transformed cells. II. Characteristics of the virus specific RNA. PMID- 4336241 TI - Mutations that affect antibiotic synthesis by Cephalosporium acremonium. PMID- 4336242 TI - [L2 and L1 radicular syndromes caused by disk hernia. 1st anatomo-clinical and diagnostic contribution]. PMID- 4336243 TI - [Virology, serology and pathomorphology of male genitalia following natural and experimental infection with IBR-IPV-virus]. PMID- 4336244 TI - [Content of quartz, hydroxyproline and lipids in pulmonary tissue and lymph nodes in patients with silicosis and silicotuberculosis]. PMID- 4336245 TI - The influence of age on organ-size changes due to tumour growth in rats. PMID- 4336246 TI - Growth of bone in school children: comparison of radiographic morphometry and photon absorptiometry. PMID- 4336248 TI - [Chemodectomas of the retroperitoneal region and the stomach]. PMID- 4336249 TI - Spontaneous mammary tumours in SPF C3H-A vy mice: formation of virus structures. PMID- 4336247 TI - Shortcomings of 99m Tc-pertechnetate as a tracer for brain tumor detection as shown by well counting of human brain tumors and a mouse ependymoblastoma. PMID- 4336250 TI - [Solubilization of isolated muscle membrane]. PMID- 4336252 TI - Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 20-1972. PMID- 4336251 TI - Acetylcholine--current status in physiology, pharmacology and medicine. PMID- 4336253 TI - [G monosomies]. PMID- 4336254 TI - [Sero-epidemiological research on the incidence of infections caused by para influenzal viruses of type 1, 2 and 3 in the Roman population]. PMID- 4336255 TI - Primary carcinoma of Bartholin's gland. A report of 24 patients. PMID- 4336256 TI - Arrhenoblastoma: three case reports. PMID- 4336257 TI - Bilateral luteomas of pregnancy with virilization. A case report. PMID- 4336258 TI - [Some features of intra- and peri-articular neoplasms]. PMID- 4336259 TI - Cyclic AMP. PMID- 4336260 TI - [Determination of plasmatic renin activity]. PMID- 4336261 TI - Effect of miscleron on serum lipid parameters in atherosclerosis induced by cholesterol. PMID- 4336262 TI - Adrenal cytomegaly. PMID- 4336263 TI - Catch-up in height and skeletal maturity in children on long-term treatment for hypothyroidism. PMID- 4336264 TI - [Blood glucose, growth hormone and plasma 11-hydroxycortico-steroids following insulin administration. Persistent hypoglycemia in patients with growth hormone deficiency]. PMID- 4336265 TI - [The oro-facial-digital syndrome. Symptoms and prognosis]. PMID- 4336266 TI - The role of viruses in the production of heart disease. PMID- 4336267 TI - Oligodeoxyribonucleotides from pulse-labeled bacterial cells. PMID- 4336268 TI - Dissociating activity of purified colicin E 2 on the isolated DNA-membrane complex of Escherichia coli. PMID- 4336269 TI - Uptake of polynucleotides by intact mammalian cells. XI. pH-dependent permeability changes for synthetic ribopolymers. PMID- 4336270 TI - Aminoacyl transfer RNA formation. II. Comparison of the mechanisms of aminoacylations stimulated by polyamines and Mg 2+ . PMID- 4336271 TI - [New synthesis of nucleotide analogues of 5'-amino-5'-desoxy-nucleosides]. PMID- 4336272 TI - Nucleotide separation on alumina. PMID- 4336273 TI - [Exanthema in herpesvirus infected horses]. PMID- 4336274 TI - Enzymic differentiation between different types of Tay-Sachs disease of similar clinical appearance. PMID- 4336275 TI - [Mechanisms of action of adrenocorticotrophic hormone]. PMID- 4336276 TI - Application of a shift reagent in nuclear magnetic resonance spectroscopy. 3. A simple identification and simultaneous determination of geometrical isomers of vitamin A. PMID- 4336277 TI - A separation of purine derivatives by thin-layer chromatography on silica gel plates suitable for metabolic studies. PMID- 4336278 TI - Liquid-solid extraction of lyophilized biological materials for forensic analysis. II. Application to bile samples for the detection of drugs. PMID- 4336279 TI - Carbon dioxide uptake during anaerobic metabolism of bovine spermatozoa. PMID- 4336280 TI - A 6 A crystallographic study of a spin-labeled inhibitor complex with lysozyme. PMID- 4336281 TI - The sense of the helix of paramyxovirus nucleocapsids. PMID- 4336282 TI - Fine structure of hepatocellular carcinoma in swine. PMID- 4336283 TI - Influence of mode of disintegration on the fibrogenetic power of quartz particles. PMID- 4336284 TI - [A case of multiple primary tumors]. PMID- 4336285 TI - [Endocrinological observation on 7 cases of Sheehan's syndrome]. PMID- 4336286 TI - [Myocarditis and primary myocardiopathies in tropical environments]. PMID- 4336287 TI - [Prostaglandins and cellular metabolism]. PMID- 4336288 TI - Chromosomes of condyloma acuminatum, Paget's disease, in situ carcinoma, invasive squamous cell carcinoma and malignant melanoma of the human vulva. PMID- 4336289 TI - [Determination of virus polluted waters from city sewage and from urban and rural purification stations]. PMID- 4336290 TI - [Kinetic studies on liver xanthinedehydrogenase. I. Activity with purine substrates]. PMID- 4336291 TI - [Total parotidectomy with conservation of the facial nerve]. PMID- 4336292 TI - [Hemarthrosis and chondrocalcinosis]. PMID- 4336293 TI - [Paraneoplastic hypercorticism. Apropos of 5 cases]. PMID- 4336294 TI - [The lymphatics of the breast and pectoral muscles]. PMID- 4336295 TI - [Adrenal hypercorticism and reticulosarcoma]. PMID- 4336296 TI - [Collection of hospital bills. (Report of the audit office)]. PMID- 4336297 TI - Management of intra-ocular infection. PMID- 4336298 TI - [Influence of temperature on complement fixation activity of the foot-and-mouth disease virus]. PMID- 4336299 TI - [The saphenous nerve syndrome in differential diagnosis of tibial meniscus injury]. PMID- 4336300 TI - [Electron microscopic studies of the renal tubules (Malpighian tubules) in Drosophila melanogaster. 3. Intracellular storage of the amino-acid 3 hydroxykynurenin]. PMID- 4336301 TI - Ultrastructural localization of acid phosphatase in the posterior pituitary of the dehydrated rat. PMID- 4336302 TI - [The ultrastructure of the adenohypophysis in the toad, Bufo bufo L. 3. Cell differentiation in the pars distalis during larval growth]. PMID- 4336303 TI - Albuminglutamate and its use in the production of pure crystalline albumin. PMID- 4336304 TI - Two haemagglutinating components of vesicular stomatitis virus. PMID- 4336305 TI - Persistent fetal tachycardia in utero prior to labor in an infant with congenital cytomegalic inclusion disease: case report. PMID- 4336306 TI - Extragenital type 2 herpesvirus infection. PMID- 4336307 TI - [Aspartokinase of Bacillus polymyxa var. Ross and its role in the synthesis of polymyxin M]. PMID- 4336308 TI - Pseudohypoparathyroidism. A disease of the second messenger (3',5'-cyclic AMP). PMID- 4336310 TI - Oxidation-reduction potential dependence of pyrophosphate-induced cytochrome and bacteriochlorophyll reactions in Rhodospirillum rubrum. PMID- 4336309 TI - Recurrent Cushing's disease following "total" adrenalectomy. PMID- 4336311 TI - On the nature of the energy-linked guantum yield change in anilino-naphthalene sulphonate fluorescence in submitochondrial particles. PMID- 4336312 TI - Biochemical and biophysical studies on cytochrome aa 3 . VII. The effect of cytochrome c on the oxidation-reduction potential of isolated cytochrome aa 3 . PMID- 4336313 TI - Identification of an electron acceptor in reaction centers of Rhodopseudomonas spheroides by EPR spectroscopy. PMID- 4336314 TI - Studies on stabilization of the oxidative phosphorylation system. II. Electron transfer-dependent resistance of succinate oxidase and NADH oxidase systems of submitochondrial particles to proteinases and cobra venom phospholipase. PMID- 4336315 TI - Transient induced oscillations in the level of ATP in Chlorella fusca. PMID- 4336316 TI - Quantization of molecular motion at the synapse and its consequences as contrasted with the generalized Turing machine. PMID- 4336317 TI - [Electroencephalographic analysis of relationships between the posterior hypothalamus and other forebrain and midbrain structures]. PMID- 4336319 TI - "Congenital pigmented epulis," "melanotic progonoma" or retinal anlage tumour. A case report. PMID- 4336318 TI - [The influence of the pituitary-adrenal system on the motor-evacuatory function of the digestive organs]. PMID- 4336320 TI - Two classes of factors affecting dream recall. PMID- 4336321 TI - Central nervous system, antidiuretic, and some other activities of pyrazoles. PMID- 4336322 TI - The multicentric origin of breast cancer. A case report of three separate primary breast carcinomas in a single patient. PMID- 4336323 TI - Thiamine in neural membranes. enzymic hydrolysis of thiamine diphosphate. PMID- 4336324 TI - Isolation of an acid-soluble protein with low molecular weight from monkey brain. PMID- 4336325 TI - The effect of neonatal thyroidectomy on the development of the adenosine 3',5' monophosphate system in the rat brain. PMID- 4336326 TI - [Treatment of amebic abscesses of the liver]. PMID- 4336327 TI - [Urinary excretion of aldosterone in experimental saturnism]. PMID- 4336328 TI - Management of the thoracic-outlet syndrome. PMID- 4336329 TI - [Immunobiological properties of Bordetella pertussis]. PMID- 4336330 TI - Surgical treatment of organic hyperinsulinism with a report of 11 cases. PMID- 4336331 TI - Isolation of lipoprotein-acid mucopolysaccharide complexes from fatty streaks of human aorta. PMID- 4336332 TI - Reliability of sleep measures. PMID- 4336333 TI - [Epidemiologic study of Staphylococcus aureus by serotyping in a hospital unit for infants]. PMID- 4336335 TI - [Electronystagmography in oculomotor paralysis]. PMID- 4336334 TI - [Functional and morphological exploration of kidneys by means of radioisotopes. (New technical possibilities)]. PMID- 4336336 TI - [Surgical forms of cerebral tuberculosis. Apropos of 3 cases, including a tuberculous abscess]. PMID- 4336337 TI - [Bilateral and primary lymphosarcoma of the adrenal glands]. PMID- 4336338 TI - [The premonitory signs of severe cerebrovascular accidents]. PMID- 4336339 TI - [Cytopenias with dyshematopoiesis after hypoglycemic sulfamide treatment. Apropos of 3 cases]. PMID- 4336340 TI - [Intermittent assisted respiration of long duration in severe respiratory failure: indications and conditions of home respirator efficacy]. PMID- 4336341 TI - [Narcotic addiction: a new social scourage in Europe]. PMID- 4336342 TI - [Uropepsin in viral hepatitis]. PMID- 4336343 TI - [The biochemical nature of the process of excitation and the development of convulsions]. PMID- 4336344 TI - [The nature of epileptic neurons]. PMID- 4336345 TI - [A microphysiologic study of neuronal phenomena in experimental photogenic epilepsy]. PMID- 4336346 TI - [Electrophysiologic, histochemical and immunologic correlates in the central mechanism of audiogenic epilepsy]. PMID- 4336347 TI - Fat metabolism in higher plants. I. The biosynthesis of polyunsaturated fatty acids by isolated spinach chloroplasts. PMID- 4336348 TI - Proteins and glycoproteins of the erythrocyte membrane. PMID- 4336349 TI - Biosynthesis of uridine diphosphate D-xylose. V. UDP-D-glucuronate and UDP-D galacturonate carboxy-lyase of Ampullariella digitata. PMID- 4336350 TI - Regulation of glycogen metabolism in the adrenal gland. II. Glycogen synthetase interconversions and their regulation bby metabolites. PMID- 4336351 TI - Interaction of spin-labeled analogues of 1, 10-phenanthroline and iodoacetamides with horse liver alcohol dehydrogenase. PMID- 4336352 TI - Limited discriminability of REM and sleep onset reports and its psychiatric implications. PMID- 4336353 TI - Human sleep after leucotomy. A case study. PMID- 4336354 TI - [Characteristics of the functional state of the thyroid gland in hyperthermia]. PMID- 4336355 TI - [Experimental studies of the mechanism of action of reserpine]. PMID- 4336357 TI - [Epidemiological studies on viruses associated with acute respiratory diseases. IV. Results of serological tests carried out in children hospitalized for acute diseases of the air ways]. PMID- 4336356 TI - Chemical characteristics of the erythrocyte receptors for picodnaviruses RV, H-1 and X 14 (brief report). PMID- 4336358 TI - [Changes in sleep stages (especially in lower mammals)]. PMID- 4336359 TI - Anterior intervertebral discectomy and arthrodesis for treatment of low back pain with or without radiculopathy. PMID- 4336360 TI - Growth retardation in steroid dependent asthma corrected by corticotrophin (ACTH). Case reports with comments. PMID- 4336361 TI - Stimulation of adenyl cyclase in pupal wing epidermis by -ecdysone. PMID- 4336362 TI - [Inhibitors of hepatic gluconeogenesis and their significance in medicine]. PMID- 4336363 TI - [The mechanism of discharge activity in the neurons of the frog primordium hippocampi]. PMID- 4336364 TI - [Localization of the 1st informational neurons of the frontal nerve in rabbits]. PMID- 4336365 TI - The glyceraldehyde 3-phosphate dehydrogenases of liver and muscle. Cooperative interactions and conditions for functional reversibility. PMID- 4336366 TI - Gene 6 exonuclease of bacteriophage T7. I. Purification and properties of the enzyme. PMID- 4336367 TI - Mechanisms of enzyme and substrate activation by lipoprotein lipase cofactors. I. A specific requirement of physiological concentrations of calcium for enzyme activity. PMID- 4336368 TI - Studies on cytochrome c peroxidase. 18. Recombination of apoenzyme with protoporphyrin and protoheme monomethyl esters. PMID- 4336369 TI - Purification and characteristics of aspartate transcarbamylase from Pseudomonas fluorescens. PMID- 4336370 TI - The metabolism of vitamin D 3 in the chick. PMID- 4336371 TI - Purification and properties of a new coupling factor required for oxidative phosphorylation in silicotungstate-treated submitochondrial particles. PMID- 4336372 TI - Studies of a flavoprotein, salicylate hydroxylse. I. Enzyme mechanism. PMID- 4336373 TI - The effects of pH and temperature on hydrogen transfer in the liver alcohol dehydrogenase mechanism. PMID- 4336374 TI - The regulation of purine utilization in bacteria. IV. Roles of membrane-localized and pericytoplasmic enzymes in the mechanism of purine nucleoside transport across isolated Escherichia coli membranes. PMID- 4336375 TI - Electromagnetic properties of hemoproteins. V. Optical and electron paramagnetic resonance characteristics of nitric oxide derivatives of metalloporphyrin apohemoprotein complexes. PMID- 4336376 TI - Changes in phospholipid turnover following growth of 3T3 mouse cells to confluency. PMID- 4336377 TI - Modifications of hydrolytic and synthetic activities of liver microsomal glucose 6-phosphatase. PMID- 4336378 TI - The specificity of glucose 6-phosphatase of intact liver microsomes. PMID- 4336379 TI - The influence of lipid on the conformation of human plasma high density apolipoproteins. PMID- 4336380 TI - The interaction between human plasma lipoproteins and connective tissue glycosaminoglycans. PMID- 4336381 TI - The behaviour of DNA on columns of histone kieselguhr. PMID- 4336382 TI - Application of column and thin-layer chromatography to the detection of artificial sweeteners in foods. PMID- 4336383 TI - Fluorigenic labelling of carbamates using dansyl chloride. 3. Thin-layer chromatographic properties of the derivatives. PMID- 4336384 TI - Analysis of phospholipids by thin-layer chromatography and X-ray emission spectrometry. PMID- 4336385 TI - A study of the chromatographic behaviour of tryptophan metabolites and related compounds by chromatography on thin layers of silica gel. I. Qualitative separation. PMID- 4336386 TI - -lactam antibiotics: their physicochemical properties and biological activities in relation to structure. PMID- 4336387 TI - [Treatment of psoriasis]. PMID- 4336388 TI - [Insulin hypoglycemia and its effect on the stomach]. PMID- 4336389 TI - Alcohol dehydrogenase in Mucorales. PMID- 4336390 TI - [Respiratory organs]. PMID- 4336391 TI - Induction of group-specific interspecies antibody in a cat by immunization with disrupted feline leukaemia virus. PMID- 4336393 TI - Molecular conformation of adenosine 3',5'-monophosphonate monohydrate. PMID- 4336392 TI - Mechanism of kasugamycin resistance in Escherichia coli. PMID- 4336394 TI - Difference in the cyclic adenosine 3',5'-monophosphate levels in normal and transformed cells. PMID- 4336395 TI - Membrane changes associated with malignancy. PMID- 4336396 TI - Nerve stump length and membrane changes in denervated skeletal muscle. PMID- 4336397 TI - Lateral dominance in tachistoscopic word recognition performances obtained with simultaneous bilateral input. PMID- 4336398 TI - [On the study of taste. Electrogustometry]. PMID- 4336399 TI - [The effect of sodium chloride on the renin-angiotensin-aldosterone systems of rats of different ages and sex]. PMID- 4336400 TI - Regulation of gene expression in Escherichia coli by cyclic AMP. PMID- 4336401 TI - On the mechanism of action of ACTH. PMID- 4336402 TI - A study of some related fields in biology. PMID- 4336403 TI - Current concepts of thyroid physiology. PMID- 4336404 TI - [Effect of actinomycin D on the activity of some enzymes of L-cells in culture]. PMID- 4336405 TI - [Antiviral and antineoplastic effect of histones]. PMID- 4336406 TI - [Goiter-cell cultures in Enterovirus and Adenovirus diagnostics]. PMID- 4336407 TI - [Multiplication of Poliomyelitis virus in oxaloacetate acid media]. PMID- 4336408 TI - [Quantitative determination of quartz in dusts using infrared spectroscopy. Application to the loam]. PMID- 4336409 TI - [Branching venous angioma and varicose veins of the spinal cord]. PMID- 4336410 TI - Active transport of Na + and K + through animal cell membranes. PMID- 4336411 TI - [Forensic veterinary evaluation of infection with equine herpes virus 1]. PMID- 4336412 TI - [Phosphatases in murine kidneys following damage by folic acid]. PMID- 4336414 TI - Changes in the molecular structure of axonal and red blood cell membranes following treatment with phospholipase A2. PMID- 4336413 TI - Identification of the sites of modification of bovine liver glutamate dehydrogenase reacted with trinitrobenzenesulfonate. PMID- 4336415 TI - Multiple forms of hepatic adenosine 3':5'-monophosphate dependent protein kinase. PMID- 4336416 TI - Preparation of fat cell membrane with high sensitivity to lipolytic hormones. PMID- 4336417 TI - Studies on the mechanism of serum stimulation of uridine uptake in serum-less mouse cells. PMID- 4336418 TI - Cholinesterase activities in subcellular fractions of rat liver. Association of acetylcholinesterase with the surface membrane and other properties of the enzyme. PMID- 4336419 TI - Studies on plasma membranes from liver cells. Separation and characterization of lipoprotein subunits of the isolated plasma membranes. PMID- 4336420 TI - Lysolecithin-casein interactions. I. Nuclear magnetic resonance and spin label studies. PMID- 4336421 TI - Extraction and purification of 1 H, 2 H, and isotope hybrid algal cytochrome, ferredoxin and flavoprotein. PMID- 4336422 TI - Cytochrome c interaction with the mitochondrial membrane: a spin label study. PMID- 4336423 TI - The problem of viral carcinogenesis: present aspects and perspectives. PMID- 4336425 TI - [Antilymphocyte globulins and neoplastic disease]. PMID- 4336426 TI - Relationship between tumor doubling time and anatomoclinical features in 50 measurable pulmonary cancers. PMID- 4336427 TI - Right lower lobe abscess in a Nigerian. PMID- 4336428 TI - Studies of the kinetics of competitive protein binding assays of cholecalciferol and 25-hydroxycholecalciferol. PMID- 4336429 TI - Circulating levels of angiotensin in man measured by radioimmunoassay. PMID- 4336430 TI - Analysis of changes in the renin-angiotensin system during pregnancy. PMID- 4336431 TI - The response of blood pressure to infusion of angiotensin II: relation to plasma concentrations of renin and angiotensin II. PMID- 4336432 TI - [Induction of tumors by Rous sarcoma virus in mice tolerant to chick antigens]. PMID- 4336433 TI - A technique for the isolation of bovine luteal cells and its application to metabolic studies of luteal cells in vitro. PMID- 4336434 TI - Effects of Na + and K + on secretion in vitro by mouse thyroid glands. PMID- 4336435 TI - Effects of Ca ++ and Mg ++ on secretion in vitro by mouse thyroid glands. PMID- 4336436 TI - Effect of triiodothyronine in the metabolism of collagen in cultured embryonic bones. PMID- 4336437 TI - Adenyl-cyclase in a transplantable thyroid tumor: loss of ability to respond to TSH. PMID- 4336438 TI - Continuance of diurnal rhythmicity of CRF activity in hypophysectomized rats. PMID- 4336439 TI - Effect of thyroxine and 5,5-diphenyl-2-thiohydantoin on enzyme activities of rat liver and kidney. PMID- 4336440 TI - Stimulatory effects of LH, FSH and prostaglandins upon cyclic 3',5'-AMP levels in porcine granulosa cells. PMID- 4336441 TI - The inability of infusions of angiotensin to elevate the plasma vasopressin in the anesthetized dog. PMID- 4336442 TI - Effect of proteolytic enzyme inhibitors on steroidogenic action of corticotropin and its synthetic analogues. PMID- 4336443 TI - [Enzyme histochemical and histological changes in the myocardium following experimental telecobalt-irradiation]. PMID- 4336444 TI - Acute lymphoblastic leukemia: virus-like particles in lymphatic cell inclusions from bone marrow and peripheral blood. PMID- 4336445 TI - Cleavage of active peptides by a lung enzyme. PMID- 4336446 TI - The effect of polyphloretin phosphate, polyoestradiol phosphate, a diphosphonate and a polyphosphate on calcification induced by dihydrotachysterol in skin, aorta and kidney of rats. PMID- 4336448 TI - Inhibitory effect of bile acids on renin angiotensinogen reaction system. PMID- 4336449 TI - The effect of neonatal thymectomy in the induction of experimental autoimmune thyroiditis in the rat. PMID- 4336450 TI - Simultaneous determination of antibody to Epstein-Barr virus in prenatal mothers and new-born infants. PMID- 4336453 TI - Developing an extended program on an inpatient service. PMID- 4336452 TI - On the use of peptidase inhibitor (Trasylol) for storage of I 125 -labelled peptide hormones (HGH, TSH, ACTH, insulin, glucagon, PTH). PMID- 4336451 TI - In vivo perfusion of human thyroid tissue with 4- 14 C-dehydroepiandrosterone and 7 - 3 H-dehydroepiandrosterone sulfate. Metabolism of steroid conjugates. X. PMID- 4336454 TI - Boarding home operators participate in workshop. PMID- 4336455 TI - Evidence for the existence of a sensitizing factor to pressor agents in the plasma of hypertensive patients. PMID- 4336456 TI - Plasma desoxycorticosterone levels in man with simultaneous measurement of aldosterone, corticosterone, cortisol and 11-deoxycortisol. PMID- 4336457 TI - Plasma renin concentration, activity and substrate in hypertension caused by oral contraceptives. PMID- 4336459 TI - Renin reactivity in normal, hypertensive, and uremic plasma. PMID- 4336458 TI - A challenge to the concept that ACTH affects growth hormone secretion in man. PMID- 4336460 TI - Viral hepatitis in Lebanon. With a review of recent advances. PMID- 4336462 TI - Portal vein blood flow determination in the unanesthetized human by umbilicoportal cannulation. PMID- 4336461 TI - The changing picture in primary carcinoma of the lung. PMID- 4336463 TI - Operative morbidity among 40 living kidney donors. PMID- 4336464 TI - Analysis of cyclic 3',5'-adenosine monophosphate and cyclic 3',5'-guanosine monophosphate. PMID- 4336465 TI - The determination of phytate and inositol phosphates. PMID- 4336466 TI - [Diagnosis and differential diagnosis of Marek's disease. 2. Pathological and histological criteria]. PMID- 4336467 TI - Spin immunoassay technique for determination of morphine. PMID- 4336468 TI - Subjective estimation of the duration of time periods in night sleep. PMID- 4336469 TI - [Local peripheral nerve lesions due to multiple causes]. PMID- 4336470 TI - [Pathogenesis of acute, non-inflammatory renal failure in the light of current experimental and clinical data]. PMID- 4336472 TI - Synovial sarcoma. A review and analysis of treated cases. PMID- 4336471 TI - Disorders of ganglioside metabolism. PMID- 4336473 TI - The biologic behavior of lung cancer according to histologic type. PMID- 4336474 TI - Surgical disease in adolescent gynecology. PMID- 4336475 TI - Insulin-secreting tumors of the pancreas: a diagnostic and therapeutic challenge. PMID- 4336476 TI - Unusual presentations in otolaryngology. PMID- 4336477 TI - [Extramitochondrial oxidative systems]. PMID- 4336478 TI - [Activity of rat liver and kidney enzymes during D2-hypervitaminosis and experimental rickets]. PMID- 4336479 TI - Sir Henry Hallett Dale and acetylcholine story. PMID- 4336480 TI - ABO blood groups and viral diseases. PMID- 4336481 TI - [Breast carcinoma treatment from the viewpoint of a small hospital]. PMID- 4336482 TI - Nuclear periphery of human glioma and meningioma cells. PMID- 4336483 TI - The contribution of fluphenazine enanthate and decanoate in the prevention of readmission of schizophrenic patients. PMID- 4336484 TI - The reticuloendothelial system in chronic bronchitis. I. Quantitative sputum cell populations during stable, acute bacterial infection, and recovery phases. PMID- 4336485 TI - Male mammary cancer: an analysis of 32 cases. PMID- 4336486 TI - Tumor associated antigen with pulmonary neoplasms. PMID- 4336487 TI - Granular cell myoblastoma: a comprehensive review of 15-years experience. PMID- 4336488 TI - Titrations of viruses on cell cultures. Pharmacology or single particle hypothesis. PMID- 4336489 TI - Kinetics of virus production in cells doubly infected with the virus of bovine diarrhea and a bovine enterovirus. PMID- 4336490 TI - Incorporation of 3 H-uridine into bovine cells doubly infected with the virus of bovine viral diarrhea and a bovine enterovirus. PMID- 4336491 TI - Influence of divinyl ether-maleic anhydride (pyran) on foot-and-mouth disease virus infection: effect on adsorption and multiplication in mouse tissues. PMID- 4336492 TI - Studies on equine herpesviruses. II. Development of a complement fixation test antigen of cell culture origin for equine herpes-l (rhinopneumonitis) virus and use in a microtitre system. PMID- 4336493 TI - Experiments on vaccination of pigs with ethyl-ethyleneimine (EEI) diethylaminoethyl dextran (DEAE-D) foot-and-mouth disease vaccines. Influence of route of inoculation and dose of antigen on the duration of immunity. PMID- 4336495 TI - Studies with a rhinovirus of bovine origin. 3. The pathogenesis and pathology of infection with strain RS 3x in calves. PMID- 4336494 TI - Spermidine stimulation of foot-and-mouth disease virus RNA-dependent RNA polymerase activity. PMID- 4336496 TI - Studies with a rhinovirus of bovine origin. IV. Neutralizing activity against strain RS 3x in bovine sera. PMID- 4336497 TI - Further characterization of an attenuated western equine encephalitis virus: search for in vitro markers. PMID- 4336498 TI - Studies of infectious bovine rhinotracheitis virus. 3. Amino acid requirements for viral replication. PMID- 4336500 TI - [Changes in the articular cartilage after hydrocortisone treatment]. PMID- 4336499 TI - On the nature of the SV 40 viral antigen induced in BSC 1 transformed cells. Brief report. PMID- 4336501 TI - Chemotherapy in malignant trophoblastic disease. PMID- 4336502 TI - A review of 31 cases of malignant trophoblastic tumours. PMID- 4336503 TI - The value of lower limb ossification centres in the radiological estimation of fetal maturity. PMID- 4336504 TI - Digital-computer-analyzed all-night sleep EEG patterns (sleep prints) in schizophrenics. PMID- 4336505 TI - Changes in ribonucleic acid degrading enzymes in ehrlich ascites cells during growth and after actinomycin D treatment. PMID- 4336506 TI - The effect of single and repeated injections of adrenocorticotropin on lipids in rat adrenals. PMID- 4336507 TI - The specific chemical cleavage of pyrophosphate diesters. PMID- 4336508 TI - The precipitation of polymerized silicic acid by urine protein: a possible mechanism in the etiology of silica urolithiasis. PMID- 4336509 TI - Streptozotocin-induced diabetes and regulation of hepatic glucose metabolism. PMID- 4336511 TI - Accumulation of adenosine 3',5'-monophosphate and relaxation in the rat uterus in vitro. PMID- 4336510 TI - Effect of - and -adrenergic stimulation on the uterine motility and adenosine 3'5'-monophosphate level. PMID- 4336512 TI - [Neurological diagnosis and course of glioblastoma]. PMID- 4336513 TI - Paresthesias, weakness, seizures, and hypophosphatemia in patients receiving hyperalimentation. PMID- 4336514 TI - Cytoplasmic crystalline inclusions in the hepatocytes of alcoholics. PMID- 4336516 TI - [Growth and puberty]. PMID- 4336515 TI - Ectopic adrenocorticotropin syndrome associated with carcinoma of the colon. PMID- 4336517 TI - Local determinants of sweating and the assessment of the "set point". PMID- 4336518 TI - General characteristics of enhanced plague formation by poliovirus in poxvirus infected cells. PMID- 4336519 TI - Mechanism of enhanced plaque formation by poliovirus in poxvirus-infected cells. PMID- 4336521 TI - An electron microscopic study of melanin in the hair and hair follicles. PMID- 4336522 TI - Collagenase and connective tissue metabolism in epidermolysis bullosa. PMID- 4336520 TI - Inhibition of the multiplication of enveloped RNA-viruses by glucosamine and 2 deoxy-D-glucose. PMID- 4336523 TI - Differences in sensitivity to vasoconstrictor drugs within the wall of the sheep carotid artery. AB - 1. Controlled heat damage was used to separate the responses of the outer innervated smooth muscle from those of the inner nerve-free smooth muscle of the sheep carotid artery.2. Preparations of smooth muscle from the inner part of the media gave 50% maximal contractions in response to approximately 1/15 the concentration of noradrenaline needed to produce similar responses from outer smooth muscle. The difference in sensitivity was greater in the lower than the upper parts of the dose-response curves.3. Much of the difference in sensitivity was still seen in the presence of Desipramine and after chronic denervation, and so could not be attributed to uptake of noradrenaline by the nerve fibres in the outer smooth muscle; disappearance of the fibres after denervation was confirmed by fluorescence microscopy.4. Similar but generally smaller differences in sensitivity between inner and outer smooth muscle were seen with respect to histamine, angiotensin II and 5-hydroxytryptamine.5. Sympathetic denervation 10 14 days previously increased the sensitivity of outer strips to noradrenaline; it usually also increased their sensitivity to histamine, suggesting that the change largely represented non-specific denervation super-sensitivity.6. The high sensitivity of the inner smooth muscle is likely to be of value in enabling it to respond to the relatively low concentration of noradrenaline reaching it in life. PMID- 4336524 TI - Control of ACh sensitivity by muscle activity in the rat. AB - 1. Rat soleus and extensor digitorum longus (EDL) muscles were examined following complete blockade of sciatic nerve impulses with anaesthetics or diphtheria toxin for periods up to 14 days.2. Muscles showed atrophy equivalent to that seen after similar periods of denervation.3. Nerve blockade appeared to have little or no effect on neuromuscular transmission when tested by stimulation beyond the block. Normal spontaneous miniature end-plate potentials were present.4. Nerve impulse blockade caused the entire muscle membrane to become sensitive to iontophoretically applied acetylcholine.5. The increase in sensitivity in soleus could be prevented by chronic nerve stimulation distal to the region of block.6. Tenotomy, of 5-12 days duration, which produced atrophy, had no effect on the sensitivity of soleus to acetylcholine.7. Chronic direct stimulation of denervated soleus or EDL muscles could prevent the usual denervation supersensitivity, or cause it to decline towards normal once it had appeared. However, the sensitivity of the end-plate region remained normal. PMID- 4336526 TI - [Osteochondromatosis of the knee in an 18-month-old child]. PMID- 4336525 TI - [Arteriography of malignant retroperitoneal tumors in children]. PMID- 4336527 TI - Survey of wild mammals in a Chesapeake Bay area for selected zoonoses. PMID- 4336528 TI - Pathogenicity for a buffalo (Syncerus caffer) of Allerton-type herpes virus isolated from a Tanzanian buffalo. PMID- 4336529 TI - Sealpox questionnaire survey. PMID- 4336530 TI - Sealpox field survey. PMID- 4336531 TI - Natural pox infection in a Golden Eagle. PMID- 4336533 TI - On a response characteristic of a mathematical neuron model. PMID- 4336532 TI - A mathematical model of the effects of spatio-temporal patterns of dendritic input potentials on neuronal somatic potentials. PMID- 4336534 TI - Mathematical model of memory trace and forgetfulness. PMID- 4336535 TI - Alterations in renal cortex following ischemic injury. 3. Ultrastructure of proximal tubules after ischemia or autolysis. PMID- 4336536 TI - The development of ultrastructural glomerular alterations in Praomys (Mastomys) natalensis. An electron microscopic study. PMID- 4336537 TI - Electron microscopy of zosteriform herpes simplex infection in the mouse. PMID- 4336538 TI - Ultrastructure of intestinal mitochondria. 3. Qualitative and quantitative changes in fasted and nonfasted suckling rats. PMID- 4336539 TI - Spontaneous stem cell leukemia in young Sprague-Dawley rats. PMID- 4336540 TI - The role of perisinusoidal cells in hepatic fibrogenesis. An electron microscopic study of acute carbon tetrachloride liver injury. PMID- 4336541 TI - Alteration of cellular and acellular alveolar and bronchiolar walls produced by hypocholesteremic drug AY9944. PMID- 4336542 TI - Further experiments on vestibular compensation. PMID- 4336543 TI - [Mononucleosis syndrome]. PMID- 4336544 TI - Radicular sensory neuropathy. PMID- 4336545 TI - [The reactivity of the mandibular joint cartilage to orthodontic stimulation during the phase of growth]. PMID- 4336546 TI - [Effect of fatty acids (linolenic, linoleic and oleic) on the growth of 2 acetylaminofluorene-induced tumors in rats]. PMID- 4336547 TI - Separation of beating cardiac myocytes from suspensions of heart cells. AB - Heart cells were obtained in suspension after incubation with collagenase and hyaluronidase in Saline A. Cardiac myocytes were separated by isopycnic centrifugation in 88.6 to 92.4% purity from other heart cells with different densities, and by velocity or rate-zonal sedimentation, in 92.8 to 97.4% purity from heart cells with different diameters. A previously described computer integration of the differential sedimentation equation was used to determine the centrifugal force, duration of centrifugation and gradient design, which would permit the separation of cardiac myocytes from other heart cells by velocity sedimentation. The myocytes continued to contract rhythmically after being recovered from the density gradients. Velocity sedimentation was superior to isopycnic sedimentation for the separation of cardiac myocytes from heart cell suspensions because it gave the most highly purified myocytes, resulted in recovery of the largest proportion of myocytes in purified fractions from the gradient and required lower centrifugal forces for shorter periods of time. The potential significance of the availability of pure cardiac myocytes is discsused. PMID- 4336550 TI - Dictyosomes in the yeast Schizosaccharomyces pombe. PMID- 4336551 TI - Automatic analysis of continuous EEG. PMID- 4336549 TI - Ultrastructural characteristics of the "hairy cells" of leukemic reticuloendotheliosis. AB - The pathognomonic neoplastic reticulum cells, or "hairy cells" of leukemic reticuloendotheliosis from 6 patients were studied with the electron microscope. These cells demonstrated characteristic ultrastructural features which were distinctly different from those of lymphocytes, monocytes, or histiocytes. In 3 patients a distinctive ribosome-lamella complex was found. The biologic significance of this unusual cytoplasmic inclusion is still unknown. Its frequent presence in leukemic reticuloendotheliosis and its rarity in other neoplastic diseases suggest a substantial yet unexplained relationship between this complex and leukemic reticuloendotheliosis. PMID- 4336548 TI - Morphologic and functional characteristics of long-term cultures of murine myeloma cells. AB - Murine myeloma cells proliferate well in cell culture even after up to 5 years in vitro and the globulin synthesized, as well as the ultrastructure, continues to be comparable to that of original tumor cells. Globulin synthesis by cultured cells from the C3H mouse tumor (x5563) ranged from 6 to 12.2 mg/g/48 hr and by cultured cells from Balb/c mouse plasmacytomas MOPC 21, 31C and 315 up to 40 mg/g/48 hr. This production is greater and occurs over a more prolonged period than those reported in other known published observations on globulin synthesis by normal or neoplastic cells from mice or other sources. However, both rate and quantity of globulin synthesis tend to decrease with time in vitro and this is inversely related to growth rate, which tends to increase with time in vitro. No evidence was found for increased globulin breakdown either intra- or extracellularly in these cultures. PMID- 4336552 TI - Paralytic poliomyelitis in Norway since the introduction of trivalent oral vaccine: an epidemiological and virological study. AB - Inactivated poliovirus vaccine was replaced by oral vaccine in Norway in the autumn of 1965. This was followed by a further decrease in the number of cases of paralytic poliomyelitis. The present study was undertaken to investigate whether the few and sporadic cases observed were caused by naturally occurring (wild) poliovirus or by vaccine virus. Trivalent oral vaccine from the same manufacturer was used throughout the campaign, whereas other similar studies have mainly been concerned with monovalent oral vaccine. Altogether 6 vaccine-associated cases were observed, giving a higher rate of paralytic cases per million doses of trivalent vaccine than reported by most authors. Epidemiological and virological findings suggest that wild poliovirus has not been circulating in the Norwegian population during recent years. PMID- 4336553 TI - [Pyrophosphate and its homologs. Role in the phospho-calcic metabolism and bone physiology]. PMID- 4336554 TI - Vaginitis in adolescent girls. PMID- 4336555 TI - A study of pyruvate metabolism in peripheral neuropathy and response to vitamin B 1 therapy. PMID- 4336556 TI - Hepatic abscess in pregnant women. PMID- 4336557 TI - Cytological and cytochemical studies of centrifuged eggs of the slug Arion ater rufus L. PMID- 4336558 TI - Aspects of spinal cord induction of chondrogenesis in chick embryo somites. PMID- 4336559 TI - Calcitonin-like activity in the circulation of osteopetrotic grey-lethal mice. PMID- 4336560 TI - Phosphodiesterase activity of rat and human adipose tissue. PMID- 4336561 TI - Contact-inhibited revertant cell lines isolated from simian virus 40-transformed cells. 3. Concanavalin A-selected revertant cells. AB - Contact-inhibited variants have been isolated by treatment of simian virus 40 (SV40)-transformed Balb/c 3T3 cells (SVT2) with the plant lectin concanavalin A. These con A revertant cells exhibit the following properties: (i) they resemble 3T3 cells morphologically and grow to saturation densities which are similar to that of 3T3 cells; (ii) they synthesize the SV40-specific T antigen and yield infectious virus after fusion with permissive monkey cells; (iii) they contain a high sialic acid content similar to that of 3T3 cells and not to that of SVT2 cells; sialic acid composition was found to be independent of serum concentration; (iv) they contain more chromosomes with the average number in the tetraploid range than the SVT2 cells from which they were derived; and (v) SVT2 and revertant cells, confluent or subconfluent, produce more collagen than Balb/3T3 cells. The relationship of surface membrane properties to contact inhibition of growth and the mechanisms for generating revertant cells are discussed. PMID- 4336562 TI - In vitro translation of cardiovirus ribonucleic acid by mammalian cell-free extracts. AB - Cell-free extracts prepared from Ehrlich ascites and mouse L cells synthesize viral proteins in response to encephalomyocarditis virus, mouse Elberfeld virus, and mengovirus ribonucleic acid. Although HeLa cell extracts are inactive, their ribosomes are functional in the presence of heterologous supernatant fractions. Synthesis depends upon the addition of adenosine triphosphate, guanosine triphosphate, an energy-generating system, and 4 mm Mg(2+). Initiation is completed during the first 10 to 20 min of incubation, but chain elongation continues for 1 hr or more. The products are of higher molecular weight than virion structural proteins and resemble polypeptides formed in virus-infected cells during a short pulse. Tryptic peptides of virion proteins and in vitro products are similar for all three cardioviruses. PMID- 4336564 TI - Comparison of murine sarcoma viruses in nonproducer and S + L - -transformed cells. AB - The biologic properties of murine sarcoma viruses in nonproducer and S(+)L(-) cells were compared. Each virus was found to be genetically stable through at least two cycles of rescue and transmission to new cells. There was no evidence for production of a defective murine leukemia virus by S(+)L(-) cells. The results are most consistent with the hypothesis that the sarcoma genome in S(+)L( ) cells contains information for replication functions which the virus in nonproducer cells either lacks or does not express. PMID- 4336563 TI - Cytoplasmic compartmentalization of the protein and ribonucleic acid species of vesicular stomatitis virus. AB - The cytoplasmic sites of synthesis in L cells of the protein and ribonucleic acid species of vesicular stomatitis virus were studied by polyacrylamide gel electrophoresis after fractionation of membrane and other cytoplasmic components by the Caliguiri-Tamm technique. The viral spike protein (glycoprotein G) was found primarily associated with a smooth membrane fraction which is rich in plasma membrane; the G protein was also present in fractions containing rough endoplasmic reticulum. The nonglycosylated envelope protein S (also called M) was found in the smooth membrane fractions but was more abundant in endoplasmic reticulum-enriched fractions. Longer labeling resulted in detection of nucleoprotein N, as well as other minor nucleocapsid proteins L and NS(1), in the cellular membrane fractions. The N protein appeared to be made in membrane-free cytoplasm along with progeny ribonucleic acid and later became associated with membrane containing G and S viral proteins. PMID- 4336565 TI - Integration of simian virus 40 deoxyribonucleic acid into the deoxyribonucleic acid of permissive monkey kidney cells. AB - Integration of simian virus 40 (SV40) deoxyribonucleic acid (DNA) into cellular DNA occurred when permissive African green monkey kidney (CV-1) cells were infected at a low multiplicity of SV40 in the presence of cytosine arabinoside. PMID- 4336566 TI - Replication of viral deoxyribonucleic acid and breakdown of cellular deoxyribonucleic acid in Epstein-Barr virus infection. AB - Infection of Raji cells with Epstein-Barr virus (EBV) causes suppression of cellular deoxyribonucleic acid (DNA) synthesis and fragmentation of the cellular DNA. About 1,000 copies of EBV DNA of normal size (about 5 x 10(7) daltons in a single strand, as shown in an alkaline gradient) are synthesized per cell. PMID- 4336567 TI - Isolation of simian virus 40 recombinants from cells infected with oligomeric forms of simian virus 40 deoxyribonucleic acid. AB - Oligomeric forms of simian virus 40 (SV40) deoxyribonucleic acid (DNA) were isolated from monkey kidney cells infected with two plaque morphology mutants of SV40. Recombinant, large clear-plaque-type SV40 was produced in cells productively infected with oligomeric forms of SV40 DNA. PMID- 4336568 TI - The fine structure of peripheral nerve lesions in a virus-induced demyelinating disease in fowl (Marek's disease). PMID- 4336569 TI - The lipid composition of microsomal preparations from lactating bovine mammary tissue. PMID- 4336570 TI - Subfractionation of S f 4-10 5 , S f 4-20 and high density lipoproteins. PMID- 4336572 TI - Antibodies to EB virus in cases of Crohn's disease. PMID- 4336573 TI - Selective effects of cholera toxin on the adrenaline responsive component of hepatic adenyl cyclase. PMID- 4336571 TI - Lipid composition of further purified bovine liver nuclear membranes. PMID- 4336574 TI - Cellular interactions in mass cultures of human diploid fibroblasts. PMID- 4336575 TI - Suppression of feeding by intracranial injections of angiotensin. PMID- 4336577 TI - [Insulinoma]. PMID- 4336576 TI - Thirst. PMID- 4336578 TI - Pheochromocytoma and recurrent chemodectomas over a twenty-five-year period. PMID- 4336580 TI - [Immunological analysis of lipoproteins]. PMID- 4336581 TI - [Structure of lipoproteins]. PMID- 4336582 TI - [Metabolism of serum lipoprotein--with special reference to metabolism of endogenous triglycerides]. PMID- 4336579 TI - [Precipitation methods for the analysis of lipoproteins]. PMID- 4336583 TI - [Lipoprotein disorders in obesity]. PMID- 4336584 TI - [Parinaud's syndrome--historical review of vertical gaze paralysis]. PMID- 4336585 TI - Incidence of cytomegalovirus infections in early childhood. PMID- 4336586 TI - Herpes zoster in childhood. PMID- 4336587 TI - Fatal cytomegalovirus infection in a previously healthy boy with myocarditis and consumption coagulopathy as presenting signs. PMID- 4336588 TI - Fatal cytomegalovirus disease in a previously healthy adult. PMID- 4336589 TI - Pneumonia as a clinical manifestation of cytomegalovirus infection in previously healthy adults. PMID- 4336590 TI - [Genital herpes simplex. A survey and description of the cytological findings]. PMID- 4336591 TI - Poly-2-vinylpyridine N-oxide reverses the immunosuppressive effects of silica and carrageenan. PMID- 4336592 TI - [The inner structure of crystallin inclusion bodies in synapses of the outer plexiform layer of the retina in the dog]. PMID- 4336594 TI - [Effect of a copper-deficient diet on the exorbital gland of the white rat]. PMID- 4336593 TI - [Enzyme-histochemical comparison between cultured pulsating and non-pulsating heart muscle cells]. PMID- 4336595 TI - [Taste buds of the dwarf catfish, Amiurus nebulosus (Lesueur). Electron microscopic and histochemical studies]. PMID- 4336596 TI - [Light and electron-microscopic changes resulting from the effects of cold on thyroid gland capillaries]. PMID- 4336597 TI - Electrophysiology of the heart: the key to understanding and management of ECG abnormalities. PMID- 4336598 TI - An experience in providing mental health care in a comprehensive prepaid group practice plan. PMID- 4336599 TI - Distribution of women physicians, 1970. PMID- 4336600 TI - [Globular cells in the connective tissue of the pharyngeal ring of Cepaea nemoralis L. (Gastropoda, Stylommatophora). I. Cellular ultrastructure]. PMID- 4336601 TI - The relation of the microglia with the pericytes in the cat cerebral cortex. PMID- 4336602 TI - [Ultrastructure of the hypophysial aminergic nerves in the teleost Gasterosteus aculeatus degenerating after application of 6 hydroxydopamine]. PMID- 4336603 TI - [Plurisecretory bronchial neoplasms with consumption coagulopathy]. PMID- 4336604 TI - [Incidence and distribution of antibodies inhibiting hemagglutination by virus parainfluenza-3 in the sera of cattle in the province of Caserta]. PMID- 4336605 TI - Effect of the kidney on angiotensinogen concentration and renin activity in plasma. PMID- 4336606 TI - Contrast filling of the pulmonary lymphatic system in the dog. PMID- 4336607 TI - [Regulation in the endocrine system: the corticotrophic partialfunction]. PMID- 4336608 TI - Ketamine anaesthesia for radiotherapy in small children. PMID- 4336609 TI - Intraendothelial inclusions in systemic lupus erythematosus. PMID- 4336610 TI - Hepatoma and HAA. PMID- 4336611 TI - An improved apparatus for the maintenance of Schistosoma mansoni and Plasmodium knowlesi or other blood protozoa in a continuous flow medium. PMID- 4336612 TI - [Genetics of skin tumours. II. Multiple cutaneous leiomyoma, multiple glomus tumours, and blue rubber-bleb nevus syndrome]. PMID- 4336613 TI - [Morphologic criteria for distinguishing between neurosecretory inclusions and lipofuscin]. PMID- 4336615 TI - [Differential diagnosis of various tumor forms in lung cytology]. PMID- 4336614 TI - Histochemical changes in rat kidney after bile duct obstruction. PMID- 4336616 TI - Interaction of some centrally active drugs with caeruloplasmin. PMID- 4336618 TI - Isolation of nuclei and characterization of ribonucleic acid synthesized in vitro from swine aortic tissue. PMID- 4336619 TI - Studies on heart phosphofructokinase. Binding of cyclic adenosine 3',5' monophosphate, adenosine monophosphate, and of hexose phosphates to the enzyme. PMID- 4336617 TI - Comparative studies of the carbohydrate-containing components of 3T3 and simian virus 40 transformed 3T3 mouse fibroblasts. PMID- 4336620 TI - Catalytic steps during the single-turnover reduction of aldehydes by alcohol dehydrogenase. PMID- 4336622 TI - [Modifications of the intermediate lobe of the hypophysis after administration of metopirone]. PMID- 4336621 TI - Diphosphopyridine nucleotide dependent isocitrate dehydrogenase from pig heart. Charactgerization of the active substrate and modes of regulation. PMID- 4336623 TI - [Transauricular hypophysectomy in the golden hamster. Its technic and control]. PMID- 4336624 TI - [Hydrolase activity in the aorta of young and mature rabbits]. PMID- 4336625 TI - [Enzymatic activity of the myoblasts isolated from the heart of chick embryos and cultivated in vitro]. PMID- 4336626 TI - [Metabolism of certain components of bone]. PMID- 4336627 TI - [Histochemical and biochemical studies of glucose-6-phosphatase in the pancreas of certain mammals]. PMID- 4336628 TI - [Comparative study of the in vitro action of dexamethasone phosphate and adenosine cyclic 3,5 monophosphate]. PMID- 4336629 TI - Adenoid cystic carcinoma of the head and neck. PMID- 4336630 TI - Histologic types of gastric carcinoma among Koreans. PMID- 4336631 TI - Family cancers among cases of primary liver cancer. PMID- 4336633 TI - Study of the tumor cell-lymphocyte interaction in patients with breast cancer. PMID- 4336632 TI - Metastatic tumors of the skin. PMID- 4336635 TI - A cytoplasmic membranous complex in histiocytosis X. PMID- 4336636 TI - Analysis of histopathologic and electron microscopic determinants of keratoacnthoma and squamous cell carcinoma. PMID- 4336634 TI - Breast cancer risk following a major salivary gland carcinoma. PMID- 4336637 TI - [Morphology, diagnosis, differential diagnosis, and early diagnosis of malignant and potentially malignant skin neoplasms. I. Basalioma, carcinoma, sarcoma of the skin]. PMID- 4336638 TI - Elimination of severe height growth suppression caused by treatment with betamethasone after switching to ACTH-depot in chronic bronchial asthma. PMID- 4336639 TI - Immunodeficiencies in chronic muco-cutaneous candidosis. PMID- 4336640 TI - Effect of protein deficiency on the response of rat uterus to intrauterine contraceptive suture. PMID- 4336641 TI - Giant cell tumour of the larynx. PMID- 4336642 TI - RNA tumor viruses, DNA polymerases, and oncogenesis: some selective effects of rifampicin derivatives. PMID- 4336643 TI - Poly I:C, an inducer of interferon and interference against virus infections. PMID- 4336644 TI - Inhibition of MSV viral function by rifampicin derivatives. PMID- 4336645 TI - [Current studies of epidemic keratoconjunctivitis, with special reference to hospital infections]. PMID- 4336646 TI - [Air pollution and ocular disorders, with special reference to photochemical smog]. PMID- 4336647 TI - Pharmacologically active peptides and their effects upon the human colon in vitro. PMID- 4336648 TI - Etiology of colonic anastomotic leaks. PMID- 4336649 TI - [Anatomo-patological criteria in the development of nephroblastoma]. PMID- 4336650 TI - [The integrative mechanism of regulation of ACTH secretion]. PMID- 4336651 TI - [Enzymatic hydrolysis of nucleic acids]. PMID- 4336652 TI - Free radicals formed in uracil and dihydrouracil by hydrogen atoms. PMID- 4336653 TI - Formation of malonate-semialdehyde: nicotinamide adenine dinucleotide (NAD) oxidoreductase in Pseudomonas fluorescens P-2. PMID- 4336655 TI - Herpesvirus type 2 in a prostitute population. PMID- 4336654 TI - Preparation of 131 I-labeled fat emulsions and distribution of the label in serum lipoproteins and lipid classes following intravenous infusion to normal and hyperlipemic subjects. PMID- 4336656 TI - [Study of phosphatase activity by continuous flow fluorometry]. PMID- 4336657 TI - [Present aspects of witchcraft in its relations with psychiatry. (May one speak of witchcraft delirium?)]. PMID- 4336658 TI - [Witchcraft delirium]. PMID- 4336659 TI - Comparison of indirect hemagglutination and immunodiffusion tests for detecting type II leukosis (Marek'ine. AB - The indirect hemagglutination and immunodiffusion tests were compared for detection of antigen and antibody to JM strain of leukosis virus infection between S- and K-line chickens. The indirect hemagglutination test was more sensitive than the immunodiffusion test for detecting the smallest amount of viral antigen and corresponding antibody in the plasma of infected chickens. The Cornell S-line had higher levels of antigen and antibody as compared with the Cornell K-line during the 20-week experimental period. PMID- 4336660 TI - Enterovirus concentration on cellulose membranes. AB - Cellulose nitrate membranes were used as one of the adsorbents in concentrating viruses from water. For adsorption to occur, salts were required. With increase in valency of salt, less salt was necessary for enhanced virus adsorption to membranes. Trivalent salts were more effective because they could be used at only 1% the concentration required for divalent salts. Thus, 0.5 mM AlCl(3) was as effective as 50 mM MgCl(2). For testing 500 gal of water, only 0.24 kg of AlCl(3) was required in contrast to 20 kg of MgCl(2). Virus could then be eluted from such membranes, having an area of 486 cm(2), with 250 ml of pH 11.5 buffer. Lowering the pH of the eluate and adding AlCl(3) permitted the virus to be quickly readsorbed on a smaller cellulose membrane, i.e., 4 cm(2). Virus for assay was eluted from the small membrane in 1 ml. This procedure has provided the basis for concentrating minute amounts of virus from large volumes of water. PMID- 4336661 TI - Evaluation of gentamicin for use in virology and tissue culture. AB - Data are presented comparing gentamicin to penicillin and streptomycin (Pen Strep) in tissue culture medium with respect to a number of parameters associated with virology and tissue culture. Unlike Pen-Strep, gentamicin was stable at pH 2 to 10 for 15 days at 37 C in tissue culture medium, and its activity was unaffected by the presence of serum. Moreover, it was stable to autoclaving. Twenty cell types replicated normally at the suggested concentration of 50 mug/ml, and all cells were unaffected by 20 times this concentration. Evidence for its practical use in virus studies was demonstrated in that (i) it was not viricidal to ribonucleic acid or deoxyribonucleic acid viruses at 40 times the suggested concentration at 37 C, (ii) the size and number of plaques were not affected by 20 times the suggested concentration, (iii) interferon assays and production were unaffected by 20 times the suggested concentrations. Gentamicin may be uniquely useful for shipment of clinical specimens and long-term tissue culture and virus studies. PMID- 4336662 TI - Preparation of poliovirus labeled with phosphorus-33. AB - Phosphorus-33 ((33)P), a weak (0.25 Mev) beta-emitting isotope of phosphorus with a half-life of 25 days, has been used to label poliovirus in cell culture. HeLa cell monolayers were depleted of phosphate and then labeled by incubating at 37 C in a medium (LM) containing about 10 muCi of (33)P as orthophosphate per ml. Labeled cells were infected at a high multiplicity with poliovirus type 1 and incubated for 8 hr in LM medium. Virus from infected cells was then concentrated and purified. Virus purity was confirmed by comparison of virus infectivity and radioactivity after CsCl density gradient centrifugation and by observing purified virus preparations with electron microscopy. With the method described, yields of about 10(10) to 5 x 10(10) plaque-forming units (PFU) of highly purified poliovirus with specific activities of about 3 x 10(-4) to 10(-3) disintegrations per min per PFU have been obtained from 1.5 x 10(8) to 3.0 x 10(8) HeLa cells. PMID- 4336663 TI - Cytopathogenic test for feline leukemia virus infections. AB - A mixed culture cytopathogenic effect with the development of multinucleated giant cells in feline leukemia virus-infected cultures after cocultivation with XC cells is described. This cytopathogenic effect has been utilized as a convenient visual marker for the detection and assay of feline leukemia virus in feline and canine embryo fibroblasts as well as in a canine tumor cell line, M 132-1. Comparison of the cytopathogenic reaction in the three cell lines indicates that the reaction is more rapid and pronounced in M-132-1 cells than in the embryo fibroblast cultures. PMID- 4336664 TI - Inhibition of thyroid secretion by sodium fluoride in vitro. PMID- 4336665 TI - Glutathione. VII. Differentiation among substrates by the thiol-oxidizing agent, diamide. PMID- 4336666 TI - The uptake and incorporation of purines by wild-type Saccharomyces cerevisiae and a mutant resistant to 4-aminopyrazolo (3,4-d) pyrimidine. PMID- 4336667 TI - Lung dust and lung iron contents of coal workers in different coalfields in Great Britain. PMID- 4336669 TI - Trapped nerves. PMID- 4336668 TI - Cytomegalovirus oesophagitis. PMID- 4336670 TI - Large-scale production of peripheral human lymphocytes for viral studies: the influence of viability and P.H.A. transformation on the growth of vesicular stomatitis virus. PMID- 4336671 TI - Bridging services from hospital to home. PMID- 4336672 TI - [Isolation and characterization of a plasma membrane fraction from the proximal tubules of human kidney]. PMID- 4336673 TI - A spectrophotometric micro-method for the enzymatic determination of beta hydroxybutyrate. PMID- 4336674 TI - [Automatic measurement of bile salts in bile with 3 -hydroxysteroid dehydrogenase]. PMID- 4336675 TI - Vitamin B 6 enzymes in normal and pre-eclamptic human placentae. PMID- 4336676 TI - A chromatographic method for aldosterone determination in human urine. PMID- 4336677 TI - Recovery cycle of the evoked heart rate response in sleeping humans. PMID- 4336678 TI - Some important occupational lung diseases. PMID- 4336679 TI - Properties of granules that contain kallikrein and renin. PMID- 4336680 TI - [Histochemical study of the action of acetylsalicylic acid on pseudocholinesterases in the rat brain]. PMID- 4336682 TI - Genetic and allied effects of certain esters of inorganic acids in Aspergillus nidulans. PMID- 4336681 TI - ACTH: differential effects of avoidance and discrimination. PMID- 4336683 TI - [Microdetermination of phosphorus in organic compounds]. PMID- 4336684 TI - [The parabasal and parachorial zones of the human placenta. II. Histochemical differences in the villi]. PMID- 4336685 TI - [The renin-angiotensin-aldosterone system during the menstrual cycle and pregnancy. Its role in pregnancy toxemia]. PMID- 4336686 TI - The nuclear localization of cyclic AMP in neonatal rat hepatocytes. PMID- 4336687 TI - Effects of chloramphenicol isomers and erythromycin on enzyme and lipid synthesis induced by oxygen in wild-type and petite yeast. AB - The synthesis of mitochondrial enzymes induced by exposure of anaerobically grown, lipid-depleted Saccharomyces cerevisiae to oxygen is inhibited by d(-) threo-chloramphenicol and erythromycin. The concentration of these antibiotics required to cause 50% inhibition of this synthesis is less than 1 mm; this is also approximately the concentration required to inhibit by the same amount mitochondrial protein synthesis in situ. The synthesis of unsaturated fatty acids, ergosterol, and phospholipid induced by aeration is inhibited by d(-) threo-chloramphenicol at high concentrations (12 mm) but is unaffected by erythromycin. l(+)-threo-Chloramphenicol affects neither enzyme nor lipid synthesis and is without effect on mitochondrial protein synthesis in situ. All three compounds inhibit the oxidative activity of isolated mitochondria; the chloramphenicol isomers also inhibit phosphorylation. In a euflavine-derived petite mutant, lacking mitochondrial protein synthesis and respiration, aeration results in the normal development of lipid in the cells, but no synthesis of mitochondrial enzymes. d(-)-threo-Chloramphenicol does not inhibit lipid synthesis in these cells. Thus inhibition of mitochondrial protein synthesis with erythromycin or genetic deletion of mitochondrial protein synthesis results in loss of the capacity to synthesize enzymes during aeration. d(-)-threo Chloramphenicol, as well as inhibiting induced enzyme formation, inhibits lipid synthesis induced by oxygen. It is unlikely that the latter effect of chloramphenicol is due to inhibition of energy production and transformation, to direct effects on lipid synthesis, or to an inhibition of mitochondrial protein synthesis. It is, however, an effect not shared with the l isomer. PMID- 4336688 TI - Effect of unsaturated fatty acids on the development of respiration and on protein synthesis in an unsaturated fatty acid mutant of Saccharomyces cerevisiae. AB - The extent of development of respiratory function induced by aeration of an anaerobically grown unsaturated fatty acid auxotroph of Saccharomyces cerevisiae is determined by the availability, endogenous or externally supplied, of unsaturated fatty acid. The synthesis of mitochondrial and cytoplasmic enzymes during aeration appears to have a similar basis of regulation by available unsaturated fatty acid. Levels of unsaturated fatty acid that permit the synthesis of mitochondrial enzymes also result in a substantial stimulation of cellular protein synthesis. PMID- 4336689 TI - Properties of a R factor which originated in Pseudomonas aeruginosa 1822. AB - RP1, a group of genes specifying resistance to carbenicillin, neomycin, kanamycin, and tetracycline and originating in a strain of Pseudomonas aeruginosa, was freely transmissible between strains of P. aeruginosa, Escherichia coli, and Proteus mirabilis. Acquisition of the multiple drug resistance specified by RP1 by these strains was accompanied by acquisition of an extrachromosomal satellite of covalently closed circular deoxyribonucleic acid of molecular weight about 40 million daltons and of buoyant density 1.719 g/cm(3) (60% guanine plus cytosine). PMID- 4336690 TI - Metabolism of nicotinamide adenine dinucleotide in human and bovine strainsof Mycobacterium tuberculosis. AB - A marked difference was found to exist between the nicotinamide adenine dinucleotide (NAD) glycohydrolase activity of human strains of Mycobacterium tuberculosis as compared with bovine strains. Human strains had from 6- to 20 fold higher NAD glycohydrolase activity than bovine strains. This finding explains the accumulation of free nicotinic acid in the culture medium by human strains and not by bovine strains. The biosynthetic intermediates nicotinic acid mononucleotide and deamido-NAD were not degraded by either human or bovine strains of M. tuberculosis; hence these nucleotides do not represent a source of the nicotinic acid accumulated by the human strains. PMID- 4336691 TI - Fructose-1,6-diphosphate-dependent lactate dehydrogenase from a cariogenic streptococcus: purification and regulatory properties. AB - The lactate dehydrogenase (LDH) from Streptococcus mutans NCTC 10449 is under stringent metabolic control. The partially purified enzyme was specifically activated by high concentrations of fructose-1,6-diphosphate (FDP) and was inhibited by adenosine triphosphate. There appeared to be at least two binding sites for the activator which interacted in a cooperative manner. The interaction between the FDP sites was independent of the pH of the assay system, although the relative affinity of the enzyme for the activator was influenced by pH. There also appeared to be at least two pyruvate binding sites on the S. mutans LDH with some cooperative interaction between them, and the interaction between these sites was also independent of the hydrogen ion concentration. Two pyruvate analogues had different effects on the interaction of pyruvate with the LDH. One of the analogues, alpha-ketobutyrate, stimulated enzyme activity at limiting pyruvate concentrations, but had no significant effect at saturating concentrations of the substrate. The net effect of alpha-ketobutyrate was to shift the pyruvate saturation curve from sigmoidal to hyperbolic and to decrease the Hill coefficient from about 2.0 to 1.0. The other pyruvate analogue, oxamate, inhibited enzyme activity at all pyruvate concentrations but had no effect on the sigmoidal nature of the pyruvate saturation curve or on the apparent kinetic order of the reaction with respect to substrate. These results suggested that there may be two types of pyruvate binding sites on the LDH from S. mutans. Other kinetic properties of the S. mutans NCTC 10449 enzyme were studied and compared with those exhibited by the LDH from several other strains of the organism. PMID- 4336693 TI - Nature of Col E 1 plasmid replication in Escherichia coli in the presence of the chloramphenicol. AB - The colicinogenic factor E(1) (Col E(1)) in Escherichia coli continues to replicate by a semiconservative mechanism in the presence of chloramphenicol (CAP) for 10 to 15 hr, long after chromosomal deoxyribonucleic acid (DNA) synthesis has terminated. Following CAP addition, the rate of synthesis of plasmid DNA gradually increases to an extent dependent on the medium employed. Within 2 to 4 hr after the addition of CAP, replication in a glucose-Casamino Acids medium approaches a maximum rate representing approximately eight times an average rate which would be required for a net doubling of DNA per cell in one generation. The number of copies of Col E(1) DNA molecules that accumulate under these conditions approaches about 3,000 copies per cell, representing a 125-fold increase over the normal level of 24 copies per cell. The system is particularly convenient for studying the mechanism of DNA replication. PMID- 4336692 TI - Mode of action of oxathiin systemic fungicides. V. Effect on electron transport system of Ustilago maydis and Saccharomyces cerevisiae. AB - The systemic fungicide carboxin (5,6-dihydro-2-methyl-1,4-oxathiin-3 carboxanilide) at 100 mum inhibited succinate cytochrome c reductase in mitochondria from Ustilago maydis and Saccharomyces cerevisiae. It did not have any effect on reduced nicotinamide adenine dinucleotide (NADH) cytochrome c reductase. Succinate coenzyme Q reductase was also inhibited, but NADH coenzyme Q reductase was not. When dichlorophenolindophenol (DCIP) was used as the terminal acceptor of electrons from the oxidation of succinate, carboxin was very effective in inhibiting succinate-DCIP reductase. Carboxin was inhibitory to succinic dehydrogenase assayed with phenazine methosulfate plus DCIP when intact mitochondria were used as the enzyme source but not when solubilized enzyme was used. The main site of action of carboxin, therefore, appears to lie between succinate and coenzyme Q. The dioxide analogue of carboxin was also effective in inhibiting succinate-cytochrome c reductase, succinate-coenzyme Q reductase, or succinate-DCIP reductase, whereas the monoxide analogue was less effective in inhibiting these enzymes. PMID- 4336695 TI - Kinetic and morphological observations on the yeast phase of Histoplasma capsulatum during protoplast formation. AB - Protoplast formation by Histoplasma capsulatum yeasts using high concentrations of MgSO(4) occurs either by lysis of the bud or lysis of the entire cell wall. Both mechanisms may also occur simultaneously. Neither the protoplast emerging through a hole in the cell wall nor the freshly released protoplast has a recognizable cell wall or the remnant of such. The protoplast contains all the organelles of the normal cell except for mesosomes. During protoplast formation the nucleus increases in size and produces several nuclear masses by the invaginations of the internal layer of the nuclear membrane. All these nuclear masses are surrounded by the external layer of the nuclear membrane. Several nuclei with a normal nuclear membrane are formed later. PMID- 4336696 TI - Demonstration of two cryptic plasmids in Salmonella pullorum MS53. AB - Two cryptic plasmids designated PO-1 and PO-2 that had molecular weights of 1.5 x 10(6) and 45 x 10(6) daltons, respectively, were isolated from Salmonella pullorum MS53. A 150 to 1 ratio of PO-1 to PO-2 plasmids was estimated to occur. PMID- 4336694 TI - Interaction of L cells and Chlamydia psittaci: entry of the parasite and host responses to its development. AB - The entry and development of Chlamydia psittaci in the L cell was studied by using purified, infectious parasites at high multiplicity. Entry of the parasite was accomplished by an act of phagocytosis by the host which was independent of an adsorption stage but was temperature-dependent. Kinetic studies of phagocytosis performed with (14)C-amino acid-labeled, purified parasites indicated that the rate of phagocytosis was directly proportional to the multiplicity of inoculation. Electron microscopy of cells infected at high multiplicity with purified infectious C. psittaci showed that phagocytosed chlamydiae were segregated in a host phagocytic vacuole throughout their developmental cycle which consisted of the transition of infecting elementary bodies to reticulate bodies dividing by binary fission, followed by the reemergence of a population of elementary bodies. The process of the transition was examined and a proposed sequence of intermediate bodies is presented. In isopycnic gradients of fractionated, infected L cells, chlamydial phagocytic vacuoles were apparent as a dense band distinct from lysosome and mitochondrion peaks, as indicated by acid phosphatase and cytochrome oxidase activities. Chlamydiae inactivated by heat or neutralized by antiserum were phagocytosed and appeared in lysosomes within 12 hr after infection according to electron microscopy; however, chlamydiae which were continuously inhibited in their development by chloramphenicol were retained intact in the cell for 24 hr without lysosomal response. The possibility of a lysosomal inhibitor on the native parasite is discussed. PMID- 4336697 TI - Incorporation of water oxygens into intracellular nucleotides and RNA. I. Predominantly non-hydrolytic RNA turnover in Bacillus subtilis. PMID- 4336698 TI - Fatty acid synthesizing systems in chick liver: influences of biotin deficiency nd dietary fat. PMID- 4336699 TI - [Transformation of mammalian cells in vitro by Rous sarcoma virus]. PMID- 4336700 TI - [Treatment of cancer and mixed tumors of the parotid salivary glands]. PMID- 4336701 TI - [Differential diagnosis of spindle-cell neoplasms in man on the basis of their ultrastructure. II. Some spindle-cell neoplasms of soft tissues (leiomyoma, leiomyosarcoma, histiocytoma and dermatofibrosarcoma protuberanus)]. PMID- 4336702 TI - [Removal of tracheal adenoid cystic carcinoma under hypothermia]. PMID- 4336703 TI - [Cytochemical methods in hematology]. PMID- 4336704 TI - [Contemporary concepts on the pathogenesis and clinical picture of diabetic neuropathy]. PMID- 4336705 TI - [Experiences with a synthetic adrenocortical hormone in the treatment of rheumatoid diseases]. PMID- 4336706 TI - [Cold-antibodies in rat serum against Yoshida-hepatom ascites cells]. PMID- 4336708 TI - Adrenalectomy in Cushing's disease. A long-term follow-up. PMID- 4336707 TI - [Early histological and histochemical changes during experimental production of liver carcinoma by diethylnitrosamine]. PMID- 4336710 TI - Relation of renal hemodynamics to angiotensin II in renal hilar lymph of the dog. PMID- 4336709 TI - Collagenolytic enzymes. PMID- 4336711 TI - Electrophysiological effects of glucagon on the normal canine heart. PMID- 4336712 TI - Effects of epinephrine and cyclic 3',5'-AMP on perfused rat hearts. PMID- 4336713 TI - Effect of hemorrhage and vasopressor agents on distribution of renal blood flow. PMID- 4336714 TI - Effect of quaternary ammonium compounds on radiocalcium movements in nerve. PMID- 4336715 TI - Extraction and excretion of renin by the isolated canine liver. PMID- 4336716 TI - Infectious bovine rhinotracheitis (Herpesvirus bovis) infection in swine. PMID- 4336717 TI - [General presentation and classification of antibiotics]. PMID- 4336718 TI - The mammalian type cytochrome c of Ustilago sphaerogena. PMID- 4336719 TI - Lactoferrin and transferrin: a comparative study. PMID- 4336720 TI - The isolation of anionic phosphoproteins from bovine cortical bone via the periodate solubilization of bone collagen. PMID- 4336721 TI - Further study on the properties of the rat liver protein involved in a paramagnetic complex in the livers of carcinogen-treated rats. PMID- 4336722 TI - [Photochemical reactions of Mg-etioporphyrin in the presence of nitric acid radical. Production of the cation-radical of Mg-etioporphyrin]. PMID- 4336723 TI - An electronic model of the neuron. PMID- 4336724 TI - The enzymatic degradation of angiotensin II analogues by proteolytic enzyme in vitro. PMID- 4336725 TI - Suppression by corticosterone of adrenocorticotropin release from adenohypophyses incubated in Krebs-Ringer bicarbonate ultrafiltered plasma. PMID- 4336726 TI - Changes in function of the neuromusclar junction occurring in tick paralysis. PMID- 4336727 TI - The pressor and myotropic effects and the antagonistic properties of several analogues of angiotensin II. PMID- 4336728 TI - Morphological parameters for assessing the functional activity of rat adrenocortical cells. PMID- 4336729 TI - Isozyme variations in human cells grown in vitro. V. Alterations in amino acid naphthylamidase isozymes in neoplastic cells and cells transformed by SV 40. PMID- 4336730 TI - [Renin-angiotensin-adiuretin system]. PMID- 4336731 TI - Relation between cancer and congenital malformations. The value of small series, with a note on pineal tumors in native and migrant Japanese. PMID- 4336733 TI - Effects of humidity and temperature on porcine plasma adrenal corticoids, ACTH and growth hormone levels. PMID- 4336732 TI - Relationship of selected cations to mucosal amino acid absorption and phosphatase activity by isolated bovine jejunal segments. PMID- 4336734 TI - Effects of "soluble silica" upon growth of lambs. PMID- 4336735 TI - [Functional analysis of the human wrist joint--servoanalysis in several peripheral nerve diseases]. PMID- 4336736 TI - An electron-microscope study of intracerebral infection of mice with low virulence Bordetella pertussis. PMID- 4336737 TI - Effects of taurocholate and cholate on strains of Clostridium welchii. PMID- 4336739 TI - Enhanced resistance of Corynebacterium parvum-treated mice to infection by bacteria. PMID- 4336738 TI - Morphological transformation of human embryo fibroblasts in vitro by EB virus. PMID- 4336740 TI - An analogue computing system for simulation of absorption, circular dichroism and ESR spectra. PMID- 4336741 TI - Pigments and signals in colour vision. PMID- 4336742 TI - The laboratory basis for the clinical treatment of Wilms tumor. PMID- 4336743 TI - [Enzymochemical studies of snake venoms. 1. Changes in biologic and enzymatic activities of various snake venoms during long-term preservation at a constant temperature]. PMID- 4336745 TI - The renin angiotensin system of amphibians. I. Determination of the renin content of amphibian kidneys. PMID- 4336744 TI - [Surgery of polysyndactylia of the toes]. PMID- 4336746 TI - The fate of radioiodinated sheep-growth hormone in intact and nephrectomized sheep. PMID- 4336747 TI - An on-ward follow-up program. PMID- 4336749 TI - A clinical and polygraphic study of the effect of a new imidazo-quinazoline derivative in narcolepsy-cataplexy. The relationship between the antidepressant and anticataplectic effects of the drug. PMID- 4336750 TI - Impairment and facilitation of memory consolidation. PMID- 4336748 TI - [Struma medicamentosa--a survey]. PMID- 4336751 TI - [Clinical study of renal diseases in childhood. 3. Clinical observations on nephrotic syndrome with special reference to its treatment and prognosis]. PMID- 4336752 TI - Dynamics of adrenal response to sustained local ACTH infusions in conscious sheep. PMID- 4336753 TI - Effect of renal medullary solutes on vasopressin-sensitive adenyl cyclase. PMID- 4336754 TI - Lung cancer: perspectives and prospects. PMID- 4336755 TI - Evoked sensory potentials in peripheral neuropathy. PMID- 4336756 TI - [Histochemical characteristics of the activity of redox enzymes and sulfhydryl groups in the cerebral cortex during sensitization and anaphylactic shock]. PMID- 4336757 TI - [Drug-induced pathomorphosis of skin lesions in leprosy]. PMID- 4336758 TI - Comparison of chromatographic patterns of low molecular weight RNA from Burkitt lymphoma, infectious mononucleosis, EB-virus transformed, and normal human lymphoblasts. PMID- 4336760 TI - Studies on human erythrocyte nucleotide metabolism. I. Monisotopic methodologies. PMID- 4336759 TI - Factor IX deficiency and bleeding in a patient with Sheehan's syndrome. PMID- 4336761 TI - [Selection of giant cells with incubation at high temperatures (41 degrees C) from a hamster cell line transformed by polyoma virus]. PMID- 4336762 TI - Condylomata acuminata. PMID- 4336763 TI - Histological evidence of tumour rejection after active immunotherapy in human malignant disease. AB - Active immunotherapy with multiple doses of tumour homogenate incorporated in complete Freund adjuvant was used to treat 12 patients with advanced malignant disease. Evidence of some tumour destruction was observed in 10. Improvement in general clinical condition and the disappearance of symptoms referable to tumour occurred in seven of the patients. The duration of improvement varied considerably. Histological evidence of lymphocytic infiltration, necrosis, and fibrous replacement of tumour tissue is presented. PMID- 4336765 TI - [Retroperitoneal tumors. Clinico-therapeutic study of 29 treated cases]. PMID- 4336764 TI - Recovery of adrenocortical function during long-term treatment with corticosteroids. AB - The recovery of adrenocortical function during long-term corticosteroid treatment in a group of patients with asthmatic bronchitis was compared with that in a group of patients with sarcoidosis. At corresponding dosages of prednisone basal adrenocortical function as well as adrenocortical response to tetracosactrin stimulation was higher in the asthma patients than in those with sarcoidosis.The rate of recovery of adrenocortical function seems mainly to be determined by the dosage of corticosteroids during the initial stages of treatment rather than by the nature of the disease. PMID- 4336767 TI - [Efforts of the World Health Organization in the field of communicable diseases]. PMID- 4336766 TI - [Intestinal parasites in citizens of the GDR travelling abroad]. PMID- 4336768 TI - [Adrenocortical function on depot-corticosteroids]. PMID- 4336769 TI - Ultrastructural changes in rat lung during long-term exposure to oxygen. PMID- 4336770 TI - Effects on serum proteins of stimulation of olfactory bulbs in spinal rats. PMID- 4336771 TI - Maintained activity of lateral geniculate nucleus neurons as a function of background luminance. PMID- 4336772 TI - The effects of 5-hydroxytryptamine and cyclic AMP on the potential profile across isolated salivary glands. PMID- 4336773 TI - New bioassay system for evaluating per cent survival of entamoeba histolytica cysts. PMID- 4336774 TI - Effects of marihuana on sleeping states. PMID- 4336775 TI - Sensory perception thresholds in patients with juvenile diabetes and their close relatives. PMID- 4336776 TI - Diabetic neuropathy. PMID- 4336777 TI - [Growth retardation]. PMID- 4336778 TI - Psychiatric outpatients. Some observations of a follow-up group. PMID- 4336779 TI - [Chemodectoma (paraganglioma, nonchromaffin) of the superior glomus laryngeus]. PMID- 4336780 TI - [Cylindroma of the accessory glandular tissue of the upper respiratory-digestive ways. (14 case reports)]. PMID- 4336781 TI - Progestin therapy for cancer of the uterine corpus. PMID- 4336782 TI - Surgical and radio-iodine therapy in thyroid carcinoma. PMID- 4336783 TI - Phasic changes in heart rate and respiration correlated with PGO-spike activity during REM sleep. PMID- 4336784 TI - Renal handling of 3'-5'-cyclic AMP in the rat. The possible role of luminal 3'-5' cyclic AMP in the tubular reabsorption of phosphate. PMID- 4336785 TI - [Clinical picture and radiotherapy of cylindromas]. PMID- 4336786 TI - Anaplastic carcinoma involving the mediastinum. PMID- 4336787 TI - Opacification of hepatic veins during celiac and hepatic angiography. PMID- 4336788 TI - [Change in adhesiveness of Zajdela rat hepatoma cells following xenotransplantation]. PMID- 4336789 TI - [Unusual cases. Congenital hallux valgus]. PMID- 4336790 TI - Ultrastructural studies of oogenesis in some european amphibians. I. Rana esculenta and rana temporaria. PMID- 4336791 TI - Long-term cell culture of two differentiated cell types from the liver of larval and adult Xenopus laevis. PMID- 4336792 TI - [Management of patients with amenorrhea and anovulatory cycle using transcerebral electrostimulation]. PMID- 4336793 TI - [Enzyme and electron microscopy studies on the preparation of membranes from rat liver mitochondria]. PMID- 4336794 TI - [Demonstration of Graffi virus-induced and species specific surface antigens in rat Graffi leukemia cells using immune-electron microscopic technics]. PMID- 4336795 TI - [Enzymatic and ultrastructural renal damage from continuous hypothermic perfusion of the isolated organ]. PMID- 4336796 TI - [Nocturnal enuresis: further elements of instrumental diagnosis]. PMID- 4336797 TI - Lithium: EEG aspects. Experimental study on the cat. PMID- 4336798 TI - [Experimental study of herpesvirus infection (effects of administration of cyclophosphamide in mice)]. PMID- 4336799 TI - Bluetongue virus in pronghorn antelope. PMID- 4336800 TI - [Blood levels of antibiotics in their combined use with heparin]. PMID- 4336802 TI - Breast reduction: is it an aid to cancer detection? PMID- 4336801 TI - [The fractionation and morphogenesis of the membrane system of Rhodopseudomonas capsulata]. PMID- 4336803 TI - [Changes in the afferent signalization of atrophying muscles]. PMID- 4336804 TI - [Virological proof of a denovirus infections in the syndrome of aspetic meningitis]. PMID- 4336805 TI - [Hepatospecific enzymes and extrahepatic pathology]. PMID- 4336806 TI - Isolation of poliomyelitis virus from a contaminated well. PMID- 4336807 TI - [Conversion of penicillins into cephalosporins]. PMID- 4336808 TI - The effect of some factors on the histochemical demonstration of liver glycogen phosphorylase activity. PMID- 4336809 TI - Cytochemical localization of peroxidase activity in Saccharomyces cerevisiae. PMID- 4336810 TI - A vertical microsystem for discontinuous electrophoresis of insect tissue proteins using thin sheets of polyacrylamide gel. PMID- 4336811 TI - [Hemagglutination inhibition antibody against Japanese encephalitis virus and the effects of vaccination on inhabitants of Fukuoka City and its environs]. PMID- 4336812 TI - Studies of SV40 DNA. 3. Differences in DNA from various strains of SV40. PMID- 4336813 TI - Neuropathological and immunofluorescence studies of experimental vesicular stomatitis virus encephalitis in mice. PMID- 4336814 TI - [Surgical treatment of insulinoma]. PMID- 4336815 TI - En bloc ethmoidectomy for cancer. (A progress report.). PMID- 4336816 TI - Chemodectomata of the glomus laryngicum superior. PMID- 4336817 TI - The biochemical properties and antibiotic susceptibility of Bacteroides melaninogenicus. PMID- 4336818 TI - [Cyclic adenosin-3',5'-monophosphate and stomach secretion. Experiments in rats]. PMID- 4336820 TI - The origin and significance of vulvar Paget's disease. PMID- 4336819 TI - Fever and bacteremia associated with hypertonic saline abortion. PMID- 4336821 TI - Carcinoma of the urachus. A case report and review. PMID- 4336822 TI - Polycystic ovarian syndrome with unilateral cystic teratoma. PMID- 4336824 TI - A quantitative procedure for the study of cells in experimentally induced granulomas. PMID- 4336823 TI - [Case of hemangiosarcoma of the nasal cavity in an infant]. PMID- 4336825 TI - Reversed polarity in transmembrane potentials of cells infected with herpesviruses. PMID- 4336826 TI - Monkeypox virus: responses of infection in chick embryos. PMID- 4336827 TI - Isolated adrenal cells: the partial agonists (Trp(Nps) 9 )ACTH 1-39 and (Trp(Nps) 9 )ACTH 1-24 (nitrophenyl sulfenyl derivatives of ACTH). PMID- 4336828 TI - Amantadine hydrochloride: inhibitory effect on murine sarcoma virus infection in cell cultures. PMID- 4336829 TI - Studies on the mechanism of the angiotensin pressor effect and of its inhibition by neotetrazolium. PMID- 4336830 TI - Effect of poly I:C on transformation by Rous sarcoma virus. PMID- 4336831 TI - The influence of mycoplasma infection on the induction of the antiviral state by polyincsinic:polycytidilic acid. PMID- 4336832 TI - Transplantation of allogeneic tumors in rats and mice treated with azathioprine, prednisone and antilymphocyte serum. PMID- 4336833 TI - RNA and protein synthesis in rhinovirus infected HeLa cells. PMID- 4336834 TI - [Rehabilitation of patients with chronic occupational dermatoses]. PMID- 4336835 TI - [New web formation method for congenital syndactylia]. PMID- 4336836 TI - Activation of water mocassin venom hemolysis of human erythrocytes by pathological and artificially altered human serum. PMID- 4336837 TI - [Prostaglandins]. PMID- 4336838 TI - [Current state of the problem of adenoviruses and their etiological role in otorhinolaryngology]. PMID- 4336839 TI - A system of periventricular glia in brain characterized by large peroxisome-like cell organelles. PMID- 4336840 TI - Morpho-topochemical studies of Golgi apparatus and Vitamin C in normal mammary gland cells of agent free C3Hf and agent carrying the MTV in C3H mouse strain. PMID- 4336841 TI - Cytochemistry of nucleotproteins in mammary gland cells of agent free C3Hf and agent carrying the MTV in C3H mouse strain. PMID- 4336842 TI - [Histochemistry of the domestic chicken kidney (Gallus domesticus L.)]. PMID- 4336843 TI - [Histochemical reaction of intermediary and exportable enzymes of the exocrine mouse pancreas modified by testosterone]. PMID- 4336844 TI - Serum cortisol in chronic schizophrenia. Changes in the response to intravenously administered insulin and ACTH on withdrawal of drugs. PMID- 4336845 TI - ACTH vs. corticosteroids in therapy-utilize one and-or the other? PMID- 4336846 TI - Trimethoprim-sulphamethoxazole in pertussis: comparison with tetracycline. PMID- 4336847 TI - Antilymphocyte serum and lymphoid cell-virus carrier culture: cell kinetics, morphology, EB virus replication, interferon. PMID- 4336848 TI - [Regulatory mechanism of the diencephalic-pituitary-adrenal system]. PMID- 4336849 TI - [Case of ectopic ACTH syndrome caused by pulmonary cancer]. PMID- 4336850 TI - Some effects of ring-A structure on the interaction of 3-oxo-steroids of the androstane series with cortisone reductase. PMID- 4336852 TI - Isoleucyl-transfer ribonucleic acid synthetase from Bacillus stearothermophilus. 2. Dynamics of the enzyme-substrate interactions. PMID- 4336851 TI - Isoleucyl-transfer ribonucleic acid synthetase from Bacillus stearothermophilus. I. Properties of the enzyme. PMID- 4336854 TI - Differences in quaternary structure and constitutive chains between two homologous forms of cytochrome b 2 (L-lactate: cytochrome c oxidoreductase). PMID- 4336853 TI - Heterotropic allosterism of monomeric haemoglobins of Chironomus thummi thummi. PMID- 4336855 TI - [Two molecular species of cytochrome b 2 from Saccharomyces cerevisiae]. PMID- 4336856 TI - Cylindrical bodies derived from endoplasmic reticulum in Leydig's cell of the rat testis. PMID- 4336857 TI - Electron microscopy in the rapid diagnosis of cytomegalovirus: ultrastructural observation and comparison of methods of diagnosis. PMID- 4336858 TI - Fatal encephalitis due to Herpesvirus hominis: use of intact brain cells for isolation of virus. PMID- 4336859 TI - Propagation of varicella-zoster virus in a diploid strain of embryonic thyroid cells from the rhesus monkey. PMID- 4336860 TI - Inhibition of cytomegalovirus by rifampin. PMID- 4336861 TI - Workshop on viral infection and diabetes mellitus in man. PMID- 4336862 TI - Effect of dimethyl sulfoxide and ficoll on rat skin. Cytochrome oxidase activity. PMID- 4336863 TI - Optical studies of a conformational change in DNA before melting. PMID- 4336864 TI - Mechanisms of resistance to mammary tumor development in C57BL and I strains of mice. I. Noduligenesis, tumorigenesis, and characteristics of nodules and tumors. PMID- 4336865 TI - Symposium on Mammary Neoplasia. Introductory remarks. PMID- 4336866 TI - Epidemiology of breast cancer in India. PMID- 4336867 TI - Considerations for epidemiologic studies to test the hypothesis of viral causation of human breast cancer. PMID- 4336868 TI - Ultrastructure of human mammary carcinoma cells in vivo and in vitro. PMID- 4336869 TI - Possible etiological role of virus particles detected in rat and monkey mammary tumors. PMID- 4336870 TI - Transformation of rat mammary cell cultures by R-35 virus isolated from spontaneous rat mammary adenocarcinoma. PMID- 4336871 TI - Cell-associated mammary tumor virus in blood of BALB-cfC3H mice. PMID- 4336872 TI - Interactions between viral and genetic factors in the origin of mammary tumors in mice. PMID- 4336873 TI - Further analysis of the detailed structure of type B and C particles. PMID- 4336874 TI - Pitfalls in the isolation of a human breast carcinoma virus in tissue culture. PMID- 4336875 TI - Primary tissue culture explants of human breast cancer. PMID- 4336876 TI - Immunologic aspects of tumor induction by mammary tumor virus. PMID- 4336877 TI - Immunization studies with mammary tumor virus. PMID- 4336878 TI - Immunological studies on human breast carcinoma and mouse mammary tumors. PMID- 4336879 TI - Effect of exogenous interferon treatment on mouse mammary tumors. PMID- 4336880 TI - Serologic and structural studies of mouse mammary tumor virus. PMID- 4336881 TI - Antigens of murine mammary tumor virus: applications to human breast cancer. PMID- 4336882 TI - RNA-directed DNA polymerase systems: not necessarily transforming Rous viruses. PMID- 4336883 TI - Reverse transciptase from Mason-Pfizer monkey tumor virus, avian myeloblastosis virus, and Rauscher leukemia virus and its response to rifamycin derivatives. PMID- 4336884 TI - Polymerase and RNA studies on milk virions from women of the Parsi community. PMID- 4336886 TI - Symposium on Mammary Neoplasia. Epilogue: quo vadis? PMID- 4336885 TI - Virus-related RNA in human and mouse mammary tumors. PMID- 4336887 TI - Maternal modification of self-recognition in ova-transfer substrains of C3H mice. PMID- 4336888 TI - The current status of mediastinoscopy. PMID- 4336889 TI - [Hypertension and hypertensive syndromes]. PMID- 4336890 TI - Frequency of occurrence of hepatocellular carcinoma in patients with porphyria cutanea tarda in long-term follow-up. PMID- 4336891 TI - [Comparative study of erythrocyte and plasma enzymes in pernicious anemia]. PMID- 4336892 TI - [Nephroblastoma in adult age and pregnancy]. PMID- 4336893 TI - Bleeding and plasma renin activity in the rat: the role of ACTH, glucocorticoids and the sympathetic nervous system. PMID- 4336894 TI - A new method for the assay of tissue collagenase. PMID- 4336895 TI - Predictability of quantitation of small virions by electron microscopy. PMID- 4336896 TI - Microcrystaline collagen (Avitene) film as a substrate for outgrowth of primary rabbit kidney fibroblasts. PMID- 4336897 TI - Effect of ultraviolet irradiation on infectivity and deoxythymidine kinase activity of herpes simplex viruses. PMID- 4336898 TI - Calcium-mediated effects of cyclic GMP on the stimulation of thymocyte proliferation by prostaglandin E 1 . PMID- 4336899 TI - Parenteral inactivated rhinovirus vaccine: minimal protective effect. PMID- 4336901 TI - In vitro growth characteristics of monkeypox virus. PMID- 4336900 TI - Incidence of herpesvirus antibody among leukemic and nasopharyngeal carcinoma patients. PMID- 4336902 TI - The effect of ACTH, group caging, and adrenalectomy in Peromyscus leucopus with emphasis on suppression of reproductive function. PMID- 4336903 TI - Experimental Herpesvirus hominis type 2 infection in nonhuman primates. PMID- 4336905 TI - Chemodectomas of the middle ear. PMID- 4336904 TI - The half-life of endogenous immunoreactive ACTH in rat plasma. PMID- 4336906 TI - Aluminium and rat lungs. The in vivo effect of small doses on the cytochrome c oxidase activity and total fibrosis produced by quartz dust. PMID- 4336908 TI - [Malignant tumor in children]. PMID- 4336907 TI - [Progress in diagnostic methods in pediatric surgery]. PMID- 4336909 TI - [Case of malignant cystosarcoma phyllodes]. PMID- 4336910 TI - Syndactyly in a rhesus monkey- a case report. PMID- 4336911 TI - Effects of transitory maternal pteroylglutamic acid (PGA) deficiency on respiratory control ratios, phosphorylative capacity, and cytochrome oxidase activities of mitochondria from rat embryos. PMID- 4336912 TI - [Healers and quacks from the spirit world. Therapeutic methods within the scope of Brazilian Umbanda]. PMID- 4336913 TI - [Cryosurgical treatment of malignant tumors of the deep regions of the brain in combination with chemotherapy]. PMID- 4336914 TI - [Distribution of succinate dehydrogenase in tumors of the astrocyte series]. PMID- 4336915 TI - [Cytological characteristics of hypophyseal adenomas]. PMID- 4336916 TI - [Immunoglobulin synthesis in the human fetus]. PMID- 4336917 TI - [Spontaneous nephroblastoma in rats]. PMID- 4336918 TI - Para-aminophenol metabolism in an established cell line with liver-like functions. PMID- 4336919 TI - Effect of denervation on the phospholipid classes in tonic and tetanic muscles. PMID- 4336920 TI - Human jejunal adenyl cyclase and phosphodiesterase. PMID- 4336921 TI - An improved micromethod for the determination of L-lactate 14 C in blood. PMID- 4336922 TI - Propagated subthreshold oscillatory response and classical electrotonic response of squid giant axon. PMID- 4336923 TI - Radiation biophysics--still of topical interest? PMID- 4336924 TI - Studies in the stability theory of complex homogeneous kinetics. I. Fundamental formalism. PMID- 4336925 TI - Ankylosing spondylitis. PMID- 4336926 TI - [Aldosterone]. PMID- 4336927 TI - [Prolactin]. PMID- 4336928 TI - [Growth hormone]. PMID- 4336929 TI - [Calcitonin]. PMID- 4336930 TI - [Insulin]. PMID- 4336931 TI - [Glucagon]. PMID- 4336932 TI - [Antidiuretic hormone (ADH)]. PMID- 4336933 TI - Syndactyly in a pig. PMID- 4336934 TI - Congenital dactylous malformations in sheep. PMID- 4336936 TI - [Comparative studies on the effectiveness of Marek vaccines in simulated field conditions]. PMID- 4336935 TI - [Possibilities of control of the Marek's disease]. PMID- 4336937 TI - [Demonstration of the vertical transmission of goose hepatitis virus]. PMID- 4336938 TI - Effect of administered mineralocorticoids or ACTH in pregnant women. Attenuation of kaliuretic influence of mineralocorticoids during pregnancy. AB - The role of augmented aldosterone production in pregnancy is poorly understood. Whereas some consider aldosterone secretion in pregnancy excessive, others suggest that this is a compensatory phenomenon. According to yet another view, mechanisms other than the renin-angiotensin-aldosterone system control sodium homeostasis in pregnancy. Metabolic balance studies were performed on 14 3rd trimester women. Mineralocorticoid activity was experimentally increased by administering desoxycorticosterone acetate, 9alpha-fluorocortisol acetate, or ACTH for 4-12 days. Administration of mineralocorticoid or ACTH consistently caused sodium retention. During this mineralocorticoid-induced volume expansion, aldosterone excretion decreased markedly. Natriuresis, which followed discontinuance of the drug, continued while aldosterone excretion, although greatly diminished compared to control values, was greater than that found in normal, nonpregnant individuals. This saline diuresis did not subside until aldosterone excretion returned to its previously high control values. These observations support the concept of the physiological role of increased aldosterone production in pregnancy. Results further revealed a marked dissociation between antinatriuretic and kaliuretic effects of corticoids. Potassium balance was virtually unaltered during continued mineralocorticoid or ACTH administration, despite initially high or abruptly increased sodium intakes. Finally, mineralocorticoid escape was induced by continued desoxycorticosterone acetate therapy in two male volunteers. Kaliuresis occurred which was subsequently abolished when progresterone was administered. Sodium excretion, however, was virtually unaltered. These data, mimicking results observed in gravidas, suggest that progesterone is an important determinant of potassium homeostasis in pregnant women. PMID- 4336939 TI - Site of stimulation of aldosterone biosynthesis by angiotensin and potassium. AB - Studies were undertaken to determine what part of the aldosterone biosynthetic pathway is stimulated by angiotensin and potassium. The availability of a method for isolating the early portion of the aldosterone pathway and a new method for measuring plasma deoxycorticosterone permitted the design of experiments to determine whether angiotensin and potassium stimulate the pathway before deoxycorticosterone. To eliminate ACTH-dependent steroid synthesis, the experiments were performed in subjects receiving constant dosage of dexamethasone. To minimize the intra-adrenal conversion of deoxycorticosterone to corticosterone, all subjects also received constant dosage of metyrapone. Plasma deoxycortisol was measured as an index of the activity of the zona fasciculata. In the absence of changes in plasma deoxycortisol, one may infer that changes in plasma deoxycorticosterone represent changes in function of zona glomerulosa, the site of aldosterone formation. Under these conditions, human subjects responded both to angiotensin and to potassium with significant increases in plasma deoxycorticosterone but without significant increases in plasma deoxycortisol. In contrast, small doses of ACTH given under similar conditions never induced increases in plasma deoxycorticosterone without simultaneously inducing large increases in plasma deoxycortisol. It is concluded that the aldosterone stimulating effects of angiotensin and potassium are, at least in part, consequences of stimulation of the biosynthetic pathway at some point before the formation of deoxycorticosterone so as to increase the availability of aldosterone precursors. PMID- 4336940 TI - Effects of adrenergic stimulation on ventilation in man. AB - The mechanism by which catecholamines affect ventilation in man is not known. Ventilatory responses to catecholamines were observed in normal subjects before and after adrenergic receptor blockade. Intravenous infusions of norepinephrine and isoproterenol caused significant increases in minute volume and decreases in end-tidal P(Co2) which were blocked by the administration of propranolol, a beta adrenergic receptor blocker. The hyperventilatory response to hypoxia was not altered by propranolol. Intravenous infusion of phenylephrine caused a small but significant decrease in minute volume which was antagonized by phentolamine, an alpha adrenergic receptor blocker. Angiotensin, a nonadrenergic pressor agent, also decreased minute volume significantly.100% oxygen was administered to suppress arterial chemoreceptors. Increases in minute volume and decreases in arterial P(Co2) in response to norepinephrine and isoproterenol were blocked by breathing 100% oxygen. The decrease in minute volume during phenylephrine was not altered by 100% oxygen. THE RESULTS INDICATE THAT: (a) beta adrenergic receptors mediate the hyperventilatory response to norepinephrine and isoproterenol but not to hypoxia. (b) the pressor agents phenylephrine and angiotensin decrease ventilation, and (c) suppression of chemoreceptors blocks the ventilatory response to norepinephrine and isoproterenol but not to phenylephrine. Implications concerning the interaction of adrenergic receptors and chemoreceptors with respect to the hyperventilatory response to catecholamines are discussed. PMID- 4336941 TI - Studies on the secretion of newly synthesized proinsulin and insulin from isolated rat islets of Langerhans. AB - Islets of Langerhans isolated from rat pancreas were incubated at 37 degrees C(95% O(2)/5% CO(2)) in buffered medium containing 1.0 mg/ml glucose and leucine (3)H for 1 hr (1st hr), washed, and incubated for an additional hr (2nd hr) in low glucose medium (0.5-1.0 mg/ml) containing unlabeled leucine. A portion of the islets was then extracted with acid-ethanol and the remainder were transferred to medium containing 3.0 mg/ml glucose and incubated for 2 hr (3rd and 4th hr) at 37 degrees C. The medium was exchanged at 30-min intervals and portions of the islets were extracted at the 3rd and 4th hr. The total amounts and specific activities of the proinsulin and insulin in the islet extracts and medium samples were determined after fractionation on Biogel P-30 columns in 3 M acetic acid. Maximal release of newly synthesized insulin occurred between the 3rd and 4th hr of incubation, confirming the results of Howell and Taylor (Biochem. J.102: 922. 1967). The high glucose medium increased the secretion of insulin approximately three to fourfold. The ratio of the specific activities of the insulin in the medium to that in the islets was about 1/1 during incubation in low glucose, but it increased to 2.5/1 during incubation with high glucose. The peak occurred at the 3rd hr, i.e., 1 hr after exposure to high glucose. The ratio of labeled proinsulin to insulin was slightly lower in the medium than in the islets. Addition of sufficient cycloheximide after the 1st hr to inhibit protein synthesis did not inhibit these responses. The specific activity of the proinsulin in the medium was about the same as that in the islets, and both were about 10-fold higher than the specific activity of the insulin. High glucose did not alter the proinsulin specific activity, which tended to decline throughout the period of observation. With cycloheximide present, the concentration of proinsulin in the islets steadily declined while the specific activity of proinsulin remained high, indicating that the proinsulin pool is small and is turning over rapidly. In terms both of amount and radioactivity proinsulin amounted to 6-7% on a molar basis of the insulin in both the medium and the islets. Addition of dibutyryl cyclic 3',5'-adenosine monophosphate (DBCAMP) (0.002 M) with high glucose during the postlabeling period slightly increased the rate of insulin secretion (133% of control) but did not significantly alter the other parameters. The results suggest that while newly synthesized insulin and proinsulin may be preferentially secreted to a slight degree, about 90% of the insulin released during 3 hr in response to glucose, or to glucose and DBCAMP, is derived from pre-existing granule stores. There were no indications of the existence of independent or nongranule pathways of insulin or proinsulin secretion. PMID- 4336942 TI - Evidence for the identity of the major apoprotein in low density and very low density lipoproteins in normal subjects and patients with familial hyperlipoproteinemia. AB - The major apoprotein(s) from human plasma low density lipoproteins was isolated and compared with a major protein fraction (fraction I) from very low density lipoproteins (VLDL). Fraction I had been previously found to comprise approximately 40% of the total protein of VLDL. Fraction I from VLDL and apoLDL from normal subjects were indistinguishable in amino acid compositions and circular dichroic spectra. They yielded indistinguishable displacement curves of LDL-(125)I by radioimmunoassay and formed immunoprecipitin lines of complete identity. Fraction I from VLDL of normal subjects was compared with the fraction isolated from patients with familial types II, III, IV, and V hyperlipoproteinemia. There were no detectable differences between any of these fractions in amino acid compositions, circular dichroic spectra, and immunochemical properties. It was, therefore, concluded that short of peptide mapping or determination of amino acid sequence, fraction I from VLDL of each subject with familial hyperlipoproteinemia appears to be identical with fraction I and apoLDL from normal individuals.A new convenient method of preparation of soluble apoLDL, modified from a procedure previously described from this laboratory, is presented. PMID- 4336943 TI - The metabolism of low density lipoprotein in familial type II hyperlipoproteinemia. AB - The metabolism of low density lipoprotein (LDL, beta lipoprotein) was studied in 10 normal individuals and 10 patients with familial type II hyperlipoproteinemia using purified radioiodinated LDL. Over 97% of the label was bound to the protein moiety of LDL and therefore the turnover data reflect the fate and distribution of LDL-apoprotein. Comparison of the metabolic behavior of biologically screened and unscreened labeled LDL preparations in dogs as well as the analysis of the urinary excretion of radioiodide derived from labeled LDL degradation in humans indicated that no significant denaturation resulted from the isolation, purification, and labeling techniques. The plasma concentration of LDL cholesterol in normals was 105+/-21 mg/100 ml (mean +/-1 SD) in contrast to 254+/ 47 mg/100 mg in patients with type II hyperlipoproteinemia; these values corresponded to LDL-apoprotein concentrations of 63+/-13 mg/100 ml and 153+/-30 mg/100 ml, respectively. Despite these differences in concentration, the synthetic rate of LDL-apoprotein in both groups was not significantly different (14.43+/-1.75 mg/kg per day in normals vs. 15.01+/-1.71 mg/kg per day in type II) nor was there any difference in the fraction of the total exchangeable LDL which was in the intravascular space (68.4+/-4.3% vs. 73.3+/-5.2%). However, the fractional catabolic rate of LDL in normal individuals differed significantly from that of patients with type II hyperlipoproteinemia (0.462+/-0.077/day in normals vs. 0.237+/-0.044/day in type II) and correspondingly the biological half life of LDL was significantly prolonged (3.08+/-0.35 days normals vs. 4.68+/-0.44 days in type II). These data indicate that the pathologic elevation of plasma LDL concentration in the individuals with type II hyperlipoproteinemia studied here is due to a decreased fractional rate of LDL degradation rather than to an abnormality of LDL synthesis. This defect of catabolism may be the primary defect in type II hyperlipoproteinemia or, alternatively, may be secondary to an underlying abnormality in lipid metabolism. PMID- 4336944 TI - Solubilized myocardial adenylate cyclase. Restoration of histamine responsiveness by phosphatidylserine. AB - We have recently described the preparation of a solubilized cat myocardial adenylate cyclase which is unresponsive to histamine, norepinephrine, glucagon, and thyroxine, the hormones which activate the particulate enzyme. Since hormone receptors may consist of proteins and phospholipids, we determined the effect of several phospholipids on restoring the responsiveness of the solubilized adenylate cyclase to histamine. The addition of phosphatidylserine completely restored the histamine-mediated activation of the solubilized enzyme in contrast to phosphatidylethanolamine and phosphatidylinositol which were without effect. The concentration of histamine producing half-maximal activation of adenylate cyclase, 2 x 10(-5) M, was virtually identical with that observed in the particulate preparation. The antihistamine, diphenhydramine, 8 x 10(-5) M, abolished activation of adenylate cyclase by histamine in both the solubilized and particulate preparations. Phosphatidylserine also restored glucagon responsiveness, but did not restore norepinephrine responsiveness. It would appear that phosphatidylserine produced the necessary molecular configuration of the adenylate cyclase for histamine binding and activation of the enzyme. PMID- 4336945 TI - Unstable variant of NADH methemoglobin reductase in Puerto Ricans with hereditary methemoglobinemia. AB - The electrophoretic mobility of erythrocyte NADH methemoglobin reductase in five hereditary methemoglobinemia patients from three Puerto Rican kindreds was 118% of normal at pH 8.6. The methemoglobin ferrocyanide reductase activity of the enzyme in erythrocyte hemolysates was 3.2-6.4% of normal. Electrophoresis of hemolysates prepared from the blood of patients from two different families at six pH values between 4.6 and 9.3 did not differentiate between the variant enzymes. Examination of the deficient enzymes extracted from the erythrocytes of one patient from each kindred revealed altered affinity for NADH and dichloroindophenol dye and decreased thermal stability. The quantitative similarity of the abnormal findings, together with the Puerto Rican origin of the kindreds, suggested that the cyanotic patients possessed the same abnormal enzyme and were thus homozygous for the same rare mutant gene. Consanguinity of the kindreds could not be established. The rates of decline of the normal and variant NADH methemoglobin reductase enzymes in vivo were measured in erythrocyte fractions of increasing cell age. The rate of decline of the variant enzyme was increased 20-fold by comparison with the normal enzyme. The methemoglobin percentage in erythrocyte fractions of increasing cell age correlated inversely with the activity of the variant. The variant enzyme averaged 37% of normal mean activity in young cells and 1% in old cells. The normal enzyme, on the other hand, lost only one-sixth of its activity as the cells aged, and the methemoglobin content in old normal cells did not rise. These observations support the hypothesis that the deficient activity and the heterogeneous pattern of methemoglobin accumulation in vivo arise principally from the accelerated inactivation of variant NADH methemoglobin reductase during the life-span of the red blood cell. PMID- 4336946 TI - Selective uptake of radioactivity by the adrenal cortex of dexamethasone-treated guinea-pigs after the administration of 131 I-labelled 1-24 adrenocorticotrophin. PMID- 4336947 TI - [Studies on air pollution in Kumamoto City]. PMID- 4336948 TI - [Mechanism of neuromuscular transmission--relationship between respiratory muscles and 2 types of skeletal muscles on development of phase II block induced by succinylcholine chloride]. PMID- 4336949 TI - Macrophage migration inhibition test: experimental and clinical studies. PMID- 4336950 TI - [Bronchiolo-alveolar carcinoma of the lung (alveolar cell carcinoma)]. PMID- 4336951 TI - Description and evaluation of a psychiatric home visiting service. PMID- 4336952 TI - Mixed tumours of the parotid gland. PMID- 4336953 TI - An unusual case of acrodystrophic neuropathy. PMID- 4336954 TI - Congenital nystagmus and sleep: a replication. PMID- 4336955 TI - The effects of continuous, high intensity, white noise on the human sleep cycle. PMID- 4336956 TI - [Spores of microorganisms. XXIV. Effect of derivatives of basic antibiotic peptides on the postgerminative development of bacterial spores]. PMID- 4336957 TI - Radioimmunochemical corticotropin determination. PMID- 4336958 TI - Input-output relation in the stretch reflex. PMID- 4336959 TI - Plaque production by carrier strains of foot-and-mouth disease virus in BHK monolayers incubated at different temperatures. PMID- 4336960 TI - Determination of different cytomegalovirus immunoglobulins (IgG, IgA, IgM) by immunofluorescence. PMID- 4336961 TI - Variable interferon productivity of Vero cells. Brief report. PMID- 4336962 TI - Investigations of the attenuation induced in foot-and-mouth disease virus by a chemical mutagen. PMID- 4336963 TI - Study of interferonogenic activity of herpes simplex virus. PMID- 4336964 TI - The development of CV-1 cells resistant to SV 40. PMID- 4336966 TI - An intersecting anti-serum pool system for the immunofluorescent identification of respiratory viruses. PMID- 4336965 TI - Inability of rubella virus interference to reverse the inhibition of cellular protein synthetis caused by poliovirus. PMID- 4336967 TI - Transformation of sheep cells by simian virus 40. PMID- 4336968 TI - The epizootiological importance of foot-and-mouth disease carriers. 3. Exposure of pigs to bovine carriers. PMID- 4336970 TI - Isolation of infectious bovine rhinotracheitis virus from the prepuce of water buffalo bulls in Australia. PMID- 4336969 TI - Protection of guinea-pigs against foot-and-mouth disease by simultaneous inoculation of sendai virus and inactivated foot-and-mouth disease vaccine. PMID- 4336971 TI - Studies on equine herpesviruses. 4. Infection of horses with a herpesvirus recovered from equine coital exanthema. PMID- 4336972 TI - [Progress in diagnosis of endocrine diseases]. PMID- 4336973 TI - [Anterior pituitary gland function test]. PMID- 4336975 TI - [Localized dysplastic odontogenesis (odontodysplasia)]. PMID- 4336974 TI - [Re-evaluation of the diagnostic value of insulin stimulation test in anterior pituitary gland function tests]. PMID- 4336976 TI - [A case of idiopathic hypoplasia of the deciduous and permanent teeth associated with eruption disorders]. PMID- 4336977 TI - [Hypothalamo-pituitary-adrenocortical function in nephrotic syndrome during synthetic corticoid treatment]. PMID- 4336978 TI - Paper chromatography combined with phosphodiesterase treatment in the determination of radioactively labelled cyclic 3',5'-adenosine monophosphate. PMID- 4336979 TI - Degradation of ( 14 C)DDT on silica gel G chromatograms under laboratory conditions. PMID- 4336980 TI - Chromatographic differentiation of erythromycin and its esters. PMID- 4336981 TI - Quantitative liquid scintillation radioassay of phospholipids from thin-layer chromatograms. PMID- 4336982 TI - Separation of histidyl-peptides by thin-layer chromatography and microspectrofluorometric characterization of their o-phthalaldehyde-induced fluorescence. PMID- 4336984 TI - Collection, storage, and insemination of canine semen. PMID- 4336983 TI - Fluorigenic labelling of carbamates with dansyl chloride. IV. In situ quantitation of N-methyl carbamate insecticides on thin-layer chromatograms. PMID- 4336985 TI - Characteristics of common helminths of the Virginia opossum (Didelphis virginiana) from North Carolina. PMID- 4336986 TI - A cytomegalovirus isolated from an owl monkey. PMID- 4336987 TI - Application of isotopic methods for measuring post-transfusion survival of stored blood in dogs. PMID- 4336988 TI - Breeding the greater bushbaby, Galago crassicaudatus, in a laboratory environment. PMID- 4336989 TI - A method for hand rearing of Saimuri sciureus. PMID- 4336990 TI - Continuous recording of erythrocyte counts and hemoglobin concentrations in the dog. PMID- 4336991 TI - Cutaneous neoplasms in the leopard frog (Rana pipiens). PMID- 4336992 TI - A device for restraining and intravenous injection of mice. PMID- 4336993 TI - The effect of paracetic acid as a disinfectant on worm eggs. PMID- 4336994 TI - Baseline hematology and blood chemistry of the South American woolly opossum, Caluromys derbianus. PMID- 4336995 TI - Amino acid levels and L-asparaginase and histaminase activities in plasma of the armadillo, Dasypus novemcinctus. PMID- 4336996 TI - Polyostotic osteophytosis in a rhesus monkey. PMID- 4336997 TI - Preliminary observations concerning antibody response to infleunza virus and sheep erythrocytes of mice infected with Plasmodium berghei. PMID- 4336998 TI - Diabetes mellitus in two rhesus monkeys. PMID- 4337000 TI - A model of renal insufficiency in the chick. PMID- 4336999 TI - Normal values for blood constituents of the baboon. II. PMID- 4337001 TI - Electrodes for recording cortical electroencephalograms in ponies. PMID- 4337002 TI - Subcutaneous relocation of carotid arteries to facilitate puncture in the conscious dog. PMID- 4337003 TI - Repeated blood sampling of Mystromys albicaudatus (white-tailed rat). PMID- 4337004 TI - Maternal deprivation: no effect on behavior and reproduction in Caw: CF No. 1 SPF mice. PMID- 4337005 TI - Animal Models and Genetic Stocks Program. PMID- 4337006 TI - The neurocalometer. A survey to assess its value as a diagnostic instrument. PMID- 4337007 TI - Severe reaction from tetracosactrin. PMID- 4337008 TI - Locally advanced breast cancer and preoperative radiotherapy. PMID- 4337009 TI - Hetacillin in childhood gastro-enteritis. PMID- 4337010 TI - [Pain in upper abdomen. I]. PMID- 4337011 TI - [Effect of S-adenosylmethionine (SAM) on platelet aggregation. In vitro and in vivo study]. PMID- 4337012 TI - Fatal pneumonia associated with adenovirus type 7 in three military trainees. PMID- 4337013 TI - Untoward effects of anticonvulsants. PMID- 4337014 TI - [Cytomegalovirus infection following kidney transplantation]. PMID- 4337015 TI - [Nobel Prize for Medicine 1971: the physiological significance of cyclic AMP]. PMID- 4337017 TI - [Crystalloid inclusions in cells of the lacrimal gland of dogs. Electron microscopic findings]. PMID- 4337016 TI - Epicillin (Dexacillin): a new semisynthetic penicillin: report of clinical experience. PMID- 4337018 TI - Multiple tumors in ophthalmology. PMID- 4337019 TI - [Changes in the activity of glucose-6-phosphate dehydrogenase, transketolase and glucose-6-phosphatase in the erythrocytes and serum of patients with different forms of retarded growth]. PMID- 4337020 TI - [Influence of the thymus gland on glucose-6-phosphatase, fructose-1,6 diphosphatase, succinate dehydrogenase, catalase, and beta-glucuronidase in thymectomized, irradiated or tumor-bearing animals]. PMID- 4337021 TI - [Effect of climatic conditions of the arid zone (Turkmenia) on corticosteroid metabolism]. PMID- 4337022 TI - [Variational character of glucocorticoid reactions in rats in response to ACTH administration and other stimuli]. PMID- 4337023 TI - [Recent advances in the study of active forms of vitamin D]. PMID- 4337024 TI - [Idiopathic cholecystogastric fistula]. PMID- 4337025 TI - Radiotherapy for extensive glomus jugulare tumors. PMID- 4337026 TI - Mastoid obliteration using homogenous bone chips and autogenous bone paste. PMID- 4337027 TI - DNA replication in SV40-infected cells. VI. The effect of cycloheximide on the formation of SV40 oligomeric DNA. PMID- 4337028 TI - Nucleotides at the RNA-DNA covalent bonds formed in the endogenous reaction by the avian myeloblastosis virus DNA polymerase. PMID- 4337029 TI - Quantitative aspects of interferon-induced plaque reduction: kinetics of interferon action. PMID- 4337030 TI - The effects of arginine starvation on macromolecular synthesis in infection with type 2 adenovirus. I. Synthesis and utilization of structural proteins. PMID- 4337031 TI - Effect of arginine starvation on macromolecular synthesis in infection with type 2 adenovirus. II. Synthesis of virus-specific RNA and DNA. PMID- 4337032 TI - Metabolic requirements for infection by Rous sarcoma virus. 3. The synthesis on viral DNA. PMID- 4337033 TI - Metabolic requirements for infection by Rous sarcoma virus. IV. Virus reproduction and cellular transformation without cellular division. PMID- 4337034 TI - The antiviral activity of certain thiophosphate and 2'-chloro substituted polynucleotide homopolymer duplexes. PMID- 4337035 TI - Alteration of DNA metabolism in fowlpox-infected chick embryo monolayers. PMID- 4337036 TI - New polypeptides in poliovirus. PMID- 4337037 TI - Equine abortion (herpes) virus: purification and concentration of enveloped and deenveloped virus and envelope material by density gradient centrifugation in colloidal silica. PMID- 4337038 TI - Identification and localization of avian leukosis group-specific antigen within "leukosis-free" chick embryos. PMID- 4337040 TI - Women in medicine: past, present and future. PMID- 4337039 TI - Early pregnancy detection using Pregnosis. PMID- 4337041 TI - The personality and family background of a sample of women medical students at the University of California. PMID- 4337042 TI - [Several x-ray and pathomorphologic correlations in tumors of the optic thalamus and subcortical brain ganglia]. PMID- 4337044 TI - [Pathologic inclusions in the mitochondria of neurons undergoing retrograde degeneration (electron microscope study)]. PMID- 4337043 TI - [The venous systems of the vertebral canal and their clinical significance in compression of the spinal cord and its roots]. PMID- 4337045 TI - Fractionation of trinucleotides from partial micrococcal nuclease digests of calf thymus DNA. PMID- 4337046 TI - Nucleotide sequence in fourteen dinucleotides, modified by 2'-O-methylation, from yeast ribonucleic acid, determined by periodate degradation and by pentose analysis. PMID- 4337048 TI - A reliable and simple method for simultaneous determination of DOPA and 3-O methyldopa in plasma and brain. PMID- 4337047 TI - Determination of ATP and ADP in blood platelets: a modification of the firefly luciferase assay for plasma. PMID- 4337049 TI - Fluorometric enzyme assay for choline and acetylcholine. PMID- 4337050 TI - Enzymic method for determining the specific activity of glucose. PMID- 4337051 TI - Pattern of dissolution of deoxyribonucleic acid in trichloroacetic acid in the presence of protein. PMID- 4337052 TI - Ultrastructure of the granular cell myoblastoma. So-called Abrikossoff's tumor. PMID- 4337053 TI - The interaction of salicylate with phospholipids. PMID- 4337054 TI - Ultrastructure of Nitrosomonas europaea cells as revealed by freeze-etching. PMID- 4337055 TI - Drug modification of digital vascular reactivity to vasoactive substances. PMID- 4337056 TI - Pattern of local purpura in man: a study of lysosomal enzymes, kinins and fibrinolysis. PMID- 4337057 TI - Mesenteric microcirculation in rats with experimental hypertension. PMID- 4337058 TI - Prostaglandin E 1 inhibition of aggregation of hamster platelets. PMID- 4337059 TI - [Fluorescence of nicotinamide-adenine dinucleotides during transport of Ca+2 ions in liver mitochondria]. PMID- 4337060 TI - [Cleavage of angiotensin II analogs by human plasma enzyme systems]. PMID- 4337061 TI - [Order of substrate binding in the ATP-P32-pyrophosphate exchange reaction, catalyzed by tryptophan: tRNA-ligase from bovine pancreas]. PMID- 4337062 TI - The submicroscopic pathologic anatomy of leprosy. PMID- 4337063 TI - Investigations on the physiopathology of the nerve in leprosy. PMID- 4337064 TI - Study of spermatic-lymphatic circulation in leprous patients with gynecomastia. PMID- 4337065 TI - Unusual presentations of leprosy. PMID- 4337066 TI - Pattern of leprosy reactions in Uganda. PMID- 4337067 TI - Juvenile angiofibroma. 2. PMID- 4337068 TI - Perchlorate blocking of 99m TcO 4 -uptake by simultaneous intravenous injection in dogs. PMID- 4337069 TI - Changes in serum proteins associated with the immunosuppressive effects of acute leucosis (Marek's disease). PMID- 4337071 TI - [Features of the clinical picture of primary cancer of the liver]. PMID- 4337070 TI - [Feminizing neoplasms of the adrenal cortex]. PMID- 4337072 TI - "Atypical" Ramsay Hunt syndrome. PMID- 4337073 TI - The hyperlipoproteinaemias: a review. PMID- 4337074 TI - Antibiotic resistance in Pseudomonas aeruginosa from infections of the ear, nose and throat. PMID- 4337075 TI - [The present status of the question of the mechanism of action of sulfanilamide hypoglycemic preparations and several aspects of their use in the treatment of diabetes mellitus]. PMID- 4337076 TI - [The effect of ACTH on pyruvic acid turnover in the brain and liver]. PMID- 4337078 TI - [Further contribution to the long roots syndrome]. PMID- 4337077 TI - [Cell components of Bordetella pertussis and their biological activities]. PMID- 4337079 TI - [ACTH in the treatment of viral hepatitis in a patient with a history of duodenal ulcer hemorrhage]. PMID- 4337080 TI - The effect of Bordetella pertussis vaccine on protease sensitivity and on the anaphylactic protease production in rats. PMID- 4337082 TI - [Studies on the soluble and particular hexokinase in Ehrlich ascites tumor cells]. PMID- 4337081 TI - [Mitochondria from rabbit reticulocytes. I. Preparation and cell criteria of purity based on cell physiology]. PMID- 4337083 TI - Bronchial oat-cell cancer producing ACTH, serotonin and catecholamine. PMID- 4337084 TI - Electron microscopic studies on the specificity of the PA-silver reaction. PMID- 4337085 TI - Serum cortisol in chronic schizophrenia. A study of the adrenocortical response to intravenously administered insulin and ACTH. PMID- 4337086 TI - Intestinal mucosae enzymatic and histochemical changes during infectious diarrhea in calves. PMID- 4337087 TI - Acute toxic dilatation limited to the ileum in Crohn's disease. PMID- 4337088 TI - Cirrhosis: morphologic dynamics for the nonmorphologist. PMID- 4337089 TI - The interaction of particulate material and dissolved foodstuffs in food uptake by Tetrahymena pyriformis. PMID- 4337090 TI - Cytomegalovirus inclusion bodies in the gastrointestinal tract. PMID- 4337091 TI - Type D Niemann-Pick disease (Nova Scotia variant). Ultrastructure of blood, skin fibroblasts, and bone marrow. PMID- 4337092 TI - [Adenosine triphosphatase activity in the plasmatic membranes of cancer cells]. PMID- 4337093 TI - [Cytologic characteristics of several histological forms of cancer of the rectum]. PMID- 4337094 TI - [Classification of soft tissue tumors in the light of general data concerning the principles of classification of blastomatous processes]. PMID- 4337095 TI - [The pathologic histology and classification of cancer of the prostate gland]. PMID- 4337096 TI - [Sex chromatin in breast tumors]. PMID- 4337097 TI - Electrolytes and behaviour in man. PMID- 4337098 TI - Why a damaged baby? PMID- 4337099 TI - Effect of adenosine 3',5'-monophosphate analogues on the activity of the cyclic adenosine 3',5'-monophosphate receptor in Escherichia coli. PMID- 4337100 TI - Localization of sialidase in the plasma membrane of rat liver cells. PMID- 4337101 TI - Tryptic conversion of cytochrome b 5 reductase to an active derivative containing two peptide chains. PMID- 4337102 TI - Characterization of the pro- 1 chain of procollagen. PMID- 4337103 TI - Effect of phospholipase C hydrolysis of membrane phospholipids on membranous enzymes. PMID- 4337104 TI - Regulation of ribosomal and transfer ribonucleic acid synthesis in Escherichia coli B-r. PMID- 4337105 TI - An adenosine triphosphate-dependent deoxyribonuclease from Hemophilus influenzae Rd. 3. Substrate specificity. PMID- 4337106 TI - Methylation of mammalian deoxyribonucleic acid. 3. Terminal versus internal location of 5-methylcytosine in oligodeoxyribonucleotides from Novikoff hepatoma cell deoxyribonucleic acid. PMID- 4337107 TI - Characterization of the ribosome-dependent guanosine triphosphatase activity of polypeptide chain initiation factor IF 2. PMID- 4337108 TI - Adenylate cyclase in skeletal muscle. Kinetic properties and hormonal stimulation. PMID- 4337109 TI - Cytochalasin A and B. Inhibition of sugar uptake in cultured cells. PMID- 4337110 TI - Stimulation of the neutral activity of rabbit liver fructose 1,6-diphosphatase by fatty acids. PMID- 4337112 TI - A preliminary survey of the epidemiology of bluetongue in Kenya. AB - A survey of the species composition and distribution of the Culicoides midge populations at a range of sites where bluetongue is enzootic isolated a group of dominant species: C. cornutus, C. grahamii, C. magnus, C. milnei, C. pallidipennis and C. 23. dagger Monthly light-trap sampling of Culicoides showed that the population densities of the dominant species greatly increased after the rain seasons and that these species concentrated around flocks of sheep and cattle. The larval habitats of C. cornutus and C. pallidipennis were found associated with stock pens. Precipitin tests on blood-fed Culicoides showed that most of the dominant species regularly feed on sheep and cattle. Bluetongue virus was isolated from C. milnei, C. pallidipennis and C. 23. Serological surveys of wild and domestic bovids from the enzootic area showed a high proportion with antibody to bluetongue virus. The colonization of C. cornutus, a potential vector, is described briefly. A causal relationship between peak rainfall in April-May, peak numbers of Culicoides in May-June and peak bluetongue incidence in June-July is postulated. The vector status of the above species and C. austeni was evaluated. PMID- 4337111 TI - A biochemical and radioautographic analysis of protein secretion by thyroid lobes incubated in vitro. AB - In this study we analyzed several aspects of protein secretion by thyroid follicular cells. The study was carried out on intact thyroid lobes obtained from newborn rats and incubated in vitro. The fate of leucine-(3)H incorporated into protein within follicular cells of untreated and thyrotropic hormone (TSH) treated lobes was traced by quantitative electron microscope radioautography. Our findings indicate that protein synthesized by the rough-surfaced endoplasmic reticulum during a pulse exposure to leucine-(3)H is released relatively slowly by this organelle. Approximately 1 hr after onset of the pulse, a peak of radioactive protein appears in the Golgi region. The significance of this peak is not clear. Newly synthesized secretory protein passes through the apex of follicular cells without being concentrated or temporarily stored there in the form of large secretory droplets. Passage probably takes place via small vesicles which are intermingled among diverse small vesicles at the apex of the cells as well as in the Golgi region. Exposure of the lobes to TSH in the incubation medium for 45 or 90 min does not stimulate incorporation of leucine-(3)H into protein. Acute stimulation with TSH does, however, modify the movement of secretory protein within the exocrine secretory apparatus of the follicular cell. It accelerates the arrival of the protein at the apex of follicular cells, and it accelerates the release of the protein into the follicular lumen. PMID- 4337113 TI - Prevalence of cytomegalovirus in France. AB - Between October 1968 and February 1970, 30 strains of cytomegalovirus were isolated from the urine of children admitted to hospitals in Lyon. Three groups of children up to the age of 14 years have been investigated.The first group consisted of 304 newborns and infants up to the age of 1 year; cytomegalovirus was grown from five of these (1.6%). Among these five children, two had cerebral disorders. None of them had ever shown any sign of typical CMV infection.The second group comprised 102 children between the ages of 1 and 14 years, from a special service for neurological and mental diseases. Cytomegalovirus was grown from 19 (18.6%).The third group was 27 children also between 1 and 14 years of age, admitted to hospital for miscellaneous diseases excluding cerebral disorders; cytomegalovirus was grown from six (22.2%).It appears that cytomegalovirus has a very low incidence in neonatal disease. The virus spreads at a higher rate in children 1-14 years old. No difference has so far been shown in the excretion rates of two groups of children, one with cerebral disorders and one with other diseases, but the number of children in the last group is too small to allow definite conclusions to be drawn. PMID- 4337116 TI - Phospholipid labelling by ( 32 P)-orthophosphate and ( 3 H)-myo-inositol in the stimulated goldfish brain in vivo. PMID- 4337115 TI - Cation modulation of synaptosomal respiration. PMID- 4337117 TI - [Therapy of autoimmune hemolytic anemias]. PMID- 4337118 TI - Cooperative care center will reduce cost of diagnosis, recuperation and education. PMID- 4337114 TI - An investigation of the possible role of phosphoinositides as regulators of action potentials by studying the effect of electrical stimulation, tetrodotoxin and cinchocaine on phosphoinositide labelling by 32 P in rabbit vagus. PMID- 4337119 TI - Prostaglandin controls neuromuscular transmission in guinea-pig vas deferens. PMID- 4337120 TI - Peripheral neuropathy and experimental myeloma in the mouse. PMID- 4337121 TI - Stimulation of adenyl cyclase by Escherichia coli enterotoxin. PMID- 4337122 TI - Progesterone facilitates implantation of xenogenic cultured cells in hamster uterus. PMID- 4337123 TI - Rapid eye movements in paradoxical sleep in infants. PMID- 4337124 TI - 1. Wilms' tumour. PMID- 4337125 TI - [Neoplasms from viruses]. PMID- 4337126 TI - Free radicals in pyrimidines. An ESR-study of electron-irradiated single crystals of 5-nitro-6-methyluracil at 77K. PMID- 4337127 TI - Alterations in growth properties and virus sensitivity of L-M cells following continuous low-level gamma irradiation. PMID- 4337128 TI - [Dose to the lung district following endolymphatic radiotherapy with Lipiodol F 131 I]. PMID- 4337129 TI - Scintigraphic studies of space-occupying liver disease. PMID- 4337130 TI - Blood pool scanning in investigating hepatic mass lesions. PMID- 4337131 TI - Dynamic vascular scintiphotography of the liver. PMID- 4337132 TI - Effects of estrogen therapy on plasma MAO activity and EEG driving responses of depressed women. PMID- 4337133 TI - Osteogenesis imperfecta: psychological function. PMID- 4337134 TI - [A Clostridium perfringens mutant producing coatless spores by lysozyme-dependent germination]. PMID- 4337135 TI - [Calculation tables of D 50 titres of viral suspensions and their accuracy]. PMID- 4337136 TI - Selective hypoaldosteronism with hyperkalemia. PMID- 4337137 TI - [Radio-clinical study of bone metastases in nephroblastoma. Apropos of 19 cases]. PMID- 4337138 TI - [Umbilico-portography with lipiodol]. PMID- 4337139 TI - Remembering dreams through autosuggestion: relationship of menstruation and ovulation to the autosuggestion dream recall cycle. PMID- 4337140 TI - Skin reactivity and infectious bovine rhinotracheitis. PMID- 4337141 TI - Reliability of acid-fast inclusions in the kidneys of cattle as an indication of lead poisoning. PMID- 4337142 TI - Hemopoietic stem cell proliferation and migration following Bordetella pertussis vaccine. PMID- 4337143 TI - Urinary excretion of endogenous and exogenous ACTH in man. PMID- 4337144 TI - Differential effects of ethidium bromide on mitochondrial and nuclear DNA synthesis in vivo in cultured mammalian cells. PMID- 4337145 TI - Enzymatic DNA modifications in isolated nuclei from developing sea urchin embryos. PMID- 4337146 TI - Pattern of birefringence in the giant amoeba, Chaos carolinensis. PMID- 4337147 TI - Activation of an Na + -dependent amino acid transport system upon fertilization of sea urchin eggs. PMID- 4337148 TI - E.P.R. of radiation-induced radicals in A- and Se-amino acids. PMID- 4337149 TI - Subcellular localization of copper in the liver of copper-deficient rats. PMID- 4337150 TI - Collagenolytic activity of cured hide bacteria. PMID- 4337151 TI - A note on the development of a polymyxin-mannitol-phenolphthalein diphosphate agar for the selective enumeration of coagulase positive staphylococci in foods. PMID- 4337152 TI - Simpler method for the determination of 5-phosphoribosyl-1-pyrophosphate in red blood cells. PMID- 4337153 TI - Interrelationship between rat serum very low density and high density lipoproteins. AB - An exchange of phospholipids and certain peptides among various classes of rat serum lipoproteins has been demonstrated and its nature has been investigated. [(32)P]-Phospholipid from isolated VLDL, prepared in vivo, was transferred to HDL, and to a much lesser extent to LDL, in vivo and in vitro. This difference between HDL and LDL can be abolished by ultracentrifugation of the serum at d 1.21. Unlabeled VLDL acquired [(32)P]phospholipid from HDL of serum. Phospholipid associated with the alpha-lipoprotein component of VLDL exchanged more readily than that associated with the beta-lipoprotein component of VLDL. Generally, the phospholipid species exchange in proportion to their distribution in the lipoproteins. Radioactivity from (3)H-labeled protein of VLDL was transferred to HDL while HDL (3)H-labeled protein in serum was transferred to VLDL during a 20 min incubation. LDL was not involved in the transfer of protein. Protein associated with the alpha-lipoprotein component of VLDL exchanged more readily than that associated with beta-lipoprotein component. Analysis of tritiated apoproteins of VLDL and HDL by polyacrylamide gel electrophoresis revealed that three of the six peptide bands of apo-VLDL exchanged between VLDL and HDL. The data raise the possibility that intact subunits of the VLDL and HDL are being exchanged. PMID- 4337154 TI - Extraction and recombination studies of the interaction of retinol with human plasma retinol-binding protein. AB - Methods have been developed for the removal of retinol from human plasma retinol binding protein (RBP), so as to form the retinol-free apoprotein, and for the recombination of apo-RBP with retinol to again form the holoprotein. Retinol is removed from RBP by gently shaking a solution of RBP with heptane under controlled conditions. During the shaking, retinol is gradually extracted from the RBP and into the heptane phase. The reassociation of apo-RBP with retinol is achieved by exposing a solution of apo-RBP to Celite coated with a thin film of retinol, followed by isolation of the RBP by gel filtration on Sephadex G-100. This procedure results in the recombination of apo-RBP with an amount of retinol almost identical with that previously removed by extraction. The two-phase extraction procedure was used to explore some of the factors which affect the interaction of retinol with RBP. The retinol-RBP complex was most stable in the lower portion of the pH range 5.6 to 10. The rate of removal of retinol from the RBP-prealbumin complex (the form in which RBP normally circulates in plasma) was markedly less than the rate of its removal from RBP alone. The interaction of retinol with RBP appears to be stabilized by the formation of the RBP-prealbumin complex. The recombination procedure was employed to examine the specificity of the binding of retinol to RBP, by determining whether compounds other than all trans-retinol would effectively bind to apo-RBP. Apo-RBP did not bind cholesterol, but displayed a slight affinity for phytol. The affinity of RBP for beta-carotene was minimal, whereas both retinyl acetate and retinal were bound about one-third as effectively as all-trans-retinol. In contrast, retinoic acid bound to apo-RBP almost as effectively as did retinol. Each of two isomers of retinol, 13-cis and 11,13-di-cis-retinol, bound to apo-RBP to some extent. The 13 cis isomer appeared to bind somewhat less effectively than did the 11,13-di-cis isomer. The binding of retinol to RBP is highly but not absolutely specific. PMID- 4337156 TI - Comparison of the triglyceride lipase of liver, adipose tissue, and postheparin plasma. AB - Heparin-released triglyceride lipase from three sources, adipose tissue, liver, and postheparin plasma, was compared. Heparin-released triglyceride lipase from liver differed in several major respects from that in adipose tissue. These differences included response to inhibitors and to high density lipoprotein in the incubation media. Heparin-released triglyceride lipase from liver, when compared with that from adipose tissue, was relatively inactive against lipoprotein substrates. The triglyceride lipase from postheparin plasma exhibited properties more like those of liver. These studies raise the possibility that triglyceride lipase in postheparin plasma may be heterogeneous and that levels of the enzyme in postheparin plasma may not accurately reflect the capacity for clearance of triglyceride from the plasma. PMID- 4337155 TI - Characterization of glycerophosphorylcholine, -ethanolamine, -serine, -inositol, and -glycerol hydrolytic activity in housefly larvae. AB - Homogenates of Musca domestica (housefly) larvae contain glycerophosphodiesterase activity, which is found in the supernatant fluid after centrifugation at 88,000 g. The phosphodiesterase is inhibited by EDTA and is stimulated by Mg(2+), Ni(2+), Co(2+), and Mn(2+). The pH optimum is 7.2. The enzyme is stable to heating at 50 degrees C for 15 min and is insensitive to sulfhydryl inhibitors. Glycerophosphoryl diesters of choline, ethanolamine, inositol, serine, glycerol, and beta-methylcholine are hydrolyzed to the common product, l-alpha glycerophosphate, and the appropriate free alcohol. The rate of glycerophosphorylcholine hydrolysis is 70% greater than the rate of hydrolysis of the other glycerophosphodiesters. Apparent K(m) values for glycerophosphorylcholine, glycerophosphorylethanolamine, and glycerophosphoryl beta-methylcholine are 2-4 x 10(-4) m, and for glycerophosphorylinositol, 2 x 10( 3) m. Competitive studies using various pairs of substrates, as well as the exchange of free choline into both glycerophosphorylcholine and glycerophosphorylinositol, suggest that a single enzyme cleaves all substrates. Product inhibition and reversal of the reaction were not detected. Choline, but not l-alpha-glycerophosphate, exchanges into glycerophosphorylcholine and glycerophosphorylinositol. PMID- 4337157 TI - Physiological fatty liver and hyperlipemia in the fetal guinea pig: chemical and ultrastructural characterization. AB - During its prolonged period of gestation, the fetal guinea pig gradually develops a striking hyperlipemia (plasma triglycerides ca. 500-1500 mg/dl) and fatty liver (hepatic triglycerides ca. 25% of wet weight). The parenchymal cells of the liver contain not only many fat droplets in the cytoplasm, but also large numbers of osmiophilic particles, interpreted as precursors of plasma lipoproteins, within profiles of the cisternae and secretory vesicles of the Golgi apparatus. Similar particles are found in intercellular spaces, in the space of Disse, and in the hepatic sinusoids. Near the end of gestation, these particles enlarge to the size range characteristic of chylomicrons secreted from the intestinal mucosa after ingestion of fat. At the same time, the hyperlipemia increases and is characterized by the accumulation of particles resembling chylomicrons morphologically and chemically. The results are interpreted as evidence of intense hepatic synthesis and secretion of very low density lipoproteins which may be related to the extensive transplacental transport of free fatty acids known to occur in this species. After birth, the hyperlipemia subsides rapidly and the hepatic steatosis more gradually. The blood plasma of the guinea pig fetus also contains moderate amounts of low density and high density lipoproteins. The latter decrease to barely detectable levels during the first 2 wk of postnatal life. Comparably low levels of high density lipoproteins are found in nonpregnant and pregnant adults. PMID- 4337158 TI - Hyperlipoproteinemia in fasting ponies. AB - Ponies fasted for up to 8 days showed, both by agarose electrophoresis and preparative ultracentrifugation, the appearance of a pre-beta-migrating, very low density lipoprotein fraction in plasma. This lipoprotein differs from the very low density lipoprotein found in humans and rats in that it contains a relatively smaller amount of total cholesterol, 85% of which is present in the unesterified form. By the 8th day of fasting, plasma triglyceride concentrations had increased from a prefasting level of 20 mg/dl to as high as 1000 mg/dl. The increase in plasma lipid concentrations as a result of fasting was highly variable. Accumulation of plasma cholesterol and triglyceride after injection of Triton WR 1339 was not related to the degree of fasting hyperlipidemia. This suggests that the hyperlipoproteinemia of fasting may result from an impaired utilization of very low density lipoproteins. PMID- 4337159 TI - Rapid assay for hormone-sensitive lipase activity of adipose tissue. AB - A highly specific and rapid assay for hormone-sensitive lipase activity of rat adipose tissue is described. The method employs emulsified 2,3-di-O-oleyl-[9,10 (3)H(2)]oleoyl glycerol as a substrate; it is very sensitive and is suitable for serial sampling. PMID- 4337161 TI - Genetic relatedness of type 1 and type 2 herpes simplex viruses. AB - The extent of homology between herpes simplex virus(1) and(2) (HSV-1 and HSV-2) deoxyribonucleic acid (DNA) was measured in two ways: (i) by determination of the relative rate of hybridization of labeled HSV-1 and HSV-2 DNA to excess unlabeled HSV-1 or HSV-2 DNA immobilized on filters and (ii) by determination of the rate of hybridization of labeled HSV-1 and HSV-2 DNA to excess unlabeled HSV-1 or HSV 2 DNA in solution. Approximately 40% of HSV-1 and HSV-2 DNA is homologous at hybridization temperatures 25 C below the melting temperature (T(m)) of HSV DNA (liquid-filter annealing). Lowering the temperature to 34 C below the T(m) increased the extent of homology to 46% (liquid annealing). The extent of base pairing in HSV-1-HSV-2 heteroduplex DNA was determined by thermal chromatography on hydroxyapatite. Heteroduplexes of HSV-1 and HSV-2 DNA eluted in a single peak whose midpoint (Te(50)) was 10 C below that of the homoduplex. Conspicuously absent were heteroduplexes that eluted at more than 15 C below the Te(50) of the homoduplex. The data indicate the existence of a variable region of DNA (54%) with very little, if any, homology and an invariable region (46%) with relatively good (85%) matching of base pairs. PMID- 4337160 TI - Mechanism of the antiviral activity resulting from sequential administration of complementary homopolyribonucleotides to cell cultures. AB - The antiviral activity of the double-stranded complex poly(rI) . poly(rC) in cell culture was restored or even surpassed if the constituent homopolymers were administered separately. Poly(rI) primed the cells for the antiviral activity of poly(rC) and poly(rC) primed for poly(rI), but neither poly(rI) nor poly(rC) primed the cells for the antiviral activity of noncomplementary homopolynucleotides. The priming effect of poly(rI) was significantly reduced if the poly(rI)-primed cells were treated with either T(1) ribonuclease or diethylaminoethyl (DEAE)-dextran before addition of poly(rC), and the priming effect of poly(rC) was significantly reduced if the poly(rC)-primed cells were treated with either pancreatic ribonuclease or DEAE-dextran before addition of poly(rI). (3)H-labeled poly(rC) bound more rapidly to poly(rI)-treated cells than to control cells. Cell-associated poly(rC) was markedly more resistant to pancreatic ribonuclease treatment if the cells had been incubated with poly(rI) before exposure to poly(rC). Our results clearly indicate that poly(rI) and poly(rC) added successively to cell cultures do not act independently but reunite at the cellular level, most likely at the outer cell membrane. PMID- 4337162 TI - Pattern of protein synthesis in monkey cells infected by simian virus 40. AB - After infection of several permanent monkey cell lines by simian virus 40 (SV40), four additional protein bands can be detected by simple sodium dodecyl sulfate polyacrylamide gel electrophoresis of whole-cell extracts. These bands appear only after the onset of viral deoxyribonucleic acid (DNA) synthesis, and inhibitors of DNA synthesis prevent their appearance. Three of them correspond to three previously identified capsid components, VP1, VP2, and VP3. The fourth protein band, which does not correspond to a previously identified virion component, is induced by SV40 infection of CV-1 and BSC-1 cultures but not by infection of MA-134 cultures. PMID- 4337163 TI - Hybridization of Rous sarcoma virus deoxyribonucleic acid polymerase product and ribonucleic acids from chicken and rat cells infected with Rous sarcoma virus. AB - Rous sarcoma virus (RSV)-specific ribonucleic acid (RNA) in virus-producing chicken cells and non-virus-producing rat cells infected with RSV was studied by hybridization with the endogenous deoxyribonucleic acid (DNA) product of the RSV virion DNA polymerase system. By hybridizing the total DNA product with excess virion RNA, the product DNA was separated into hybridized ("minus") and nonhybridized ("plus") DNA. The "minus" DNA was complementary to at least 20% of the RNA from RSV which remained of high molecular weight after denaturation. A maximum of approximately 65% hybridization was observed between "minus" DNA and RSV RNA or RSV-infected chicken cell RNA. A maximum of about 60% hybridization was observed between "minus" DNA and RSV-infected rat cell RNA. RSV-infected chicken cells contained RSV-specific RNA equivalent to about 6,000 virions per cell. RSV-infected rat cells contained RSV-specific RNA equivalent to approximately 400 virions per cell. Neither cell type contained detectable RNA complementary to virion RNA. The RSV-specific RNA in RSV-infected rat cells did not appear to be qualitatively different from that in RSV-infected chicken cells. PMID- 4337164 TI - Selective association of Sindbis virion proteins with different membrane fractions of infected cells. AB - Plasma and smooth membranes obtained from chicken embryo cells infected with Sindbis virus were solubilized and subjected to electrophoresis on acrylamide gels. The electrophoretic patterns showed that (i) the major proteins synthesized and associated with plasma membranes from infected cells are virion proteins and (ii) at 4 hr after infection virion proteins are not present at detectable levels in the smooth membranes of the cell. PMID- 4337165 TI - Endonuclease activity associated with purified simian virus 40 virions. AB - Purified simian virus 40 has associated with it an endonuclease activity which converts form I (double-stranded, circular) simian virus 40 deoxyribonucleic acid to a nicked form that sediments as a homogeneous peak in alkaline sucrose gradients. The enzyme is dependent on magnesium ions for activity and is completely inhibited by ethylenediaminetetraacetic acid (0.02 m) or heat (80 C for 10 min). In tris(hydroxymethyl)aminomethane-hydrochloride buffer it exhibits optimal activity between pH 6.7 and 7.1 at 37 C. Gel electrophoretic analysis of purified, disrupted virus indicates the absence of detectable host cell protein contamination. PMID- 4337166 TI - Effect of Sendai virus infection on lipid metabolism in chick embryo fibroblasts. AB - Lipid metabolism in the "abortive" system, Sendai virus-infected primary chick embryo fibroblasts, was examined by using (32)P-orthophosphate, (14)C-glucose, and (14)C-glycerol as precursors. Incorporation of radioactivity from (32)P orthophosphate and (14)C-glucose into lipid was increased in infected cells. Synthesis of all individual phospholipids was about equally stimulated. There was also evidence for increased lipid synthesis in more productively infected monkey kidney cells. Incorporation of (14)C-glycerol when at a high level in the medium was also increased. However, when this precursor was supplied in minute quantities of high specific activity, incorporation was inhibited. Even though incorporation of radioactivity from (14)C-glucose was stimulated during long labeling periods, the uptake of this precursor during short pulses was inhibited in infected cells. The phenomenon of increased labeling of triglyceride in infected chick cells under certain conditions is discussed, in conjunction with the other effects, in terms of related changes in other virus-infected systems. PMID- 4337167 TI - Gene order of encephalomyocarditis virus as determined by studies with pactamycin. AB - Previous work has shown that translation of the encephalomyocarditis (EMC) viral ribonucleic acid (RNA) generates at least three primary products, polypeptides A, F, and C. The A and C polypeptides then undergo post-translational cleavages to complete the production of the stable viral polypeptides (delta, beta, gamma, alpha, G, I, F, H, and E). In this communication we show that A, F, and C are produced in equimolar amounts giving further support to the theory that the RNA of picornaviruses has only a single site for the initiation of protein synthesis. The biosynthesis of viral proteins in EMC virus-infected HeLa cells was studied in the presence of pactamycin at concentrations which preferentially inhibit the initiation of protein synthesis. The amount of each polypeptide formed during the residual period of protein synthesis observed after the addition of pactamycin was used as a criterion for ordering the genes on the viral RNA. The results obtained indicate that the primary gene products are ordered on the EMC viral RNA 5' --> 3' A-F-C and that the stable products are ordered delta-beta-gamma-alpha-G I-F-H-E. Moreover, the intermediate chains B and epsilon map in the capsid region, whereas the intermediate chain D maps in the E region. This order is largely consistent with previously established relationships of the viral polypeptides and thus indicates that pactamycin is a valid tool for "genetic" mapping of polycistronic RNA molecules with single initiation sites. PMID- 4337168 TI - Trypsin action on the growth of Sendai virus in tissue culture cells. II. Restoration of the hemolytic activity if L cell-borne Sendai virus by trypsin. AB - Sendai virus grown in L cells (L Sendai) caused little hemolysis, whereas the one grown in fertile eggs (egg Sendai) induced distinct hemolysis. Enzymatic treatment with trypsin at low concentrations markedly enhanced the hemolytic activity of L Sendai but not that of egg Sendai. Both sonic treatment and freezing and thawing greatly enhanced the hemolytic activity of egg Sendai, but they gave little enhancing effect on that of L Sendai which could, however, be greatly increased by successive treatment with trypsin. Dose response and kinetic experiments on the trypsin effect have suggested that a similarity exists in the inhibitory mechanism of infectivity for L cells and hemolytic activity of L Sendai. Treatment of L cells with trypsin at later stages of infection released a highly hemolytic L Sendai from those cells. The present study, by reference to the density centrifugation studies in a previous report (4), has shown that a variation in infectivity for L cells and in the hemolytic activity of L Sendai is a type of host-controlled modification distinguishable from the density variation. PMID- 4337169 TI - Solubilization of envelopes of HVJ (Sendai virus) with alkali-emasol treatment and reassembly of envelope particles with removal of the detergent. AB - The envelopes of HVJ (Sendai virus) virions were solubilized with alkali-Emasol treatment. The solubilized envelope subunit(s) associated with hemagglutination inhibiting antibody blocking, neuraminidase, and low hemagglutinating (HA) activities had a sedimentation coefficient of 8.8S. Envelope fragment-like structures were assembled from the solubilized subunits after Emasol was removed by gel filtration. These reassembled envelope particles with HA activity had cell fusion activity as well as hemolytic activity. Sodium dodecyl sulfate polyacrylamide gel electrophoresis of the reassembled particles revealed that they mainly consisted of two kinds of polypeptides. PMID- 4337171 TI - [Bronchial asthma and infection. 1. Role of influenza virus in bronchial asthma]. PMID- 4337170 TI - The coronary drug project. Findings leading to further modifications of its protocol with respect to dextrothyroxine. The coronary drug project research group. PMID- 4337172 TI - [The mechanism of action of antibiotics]. PMID- 4337173 TI - Effects of a single administration of L-asparaginase on serum lipids. PMID- 4337174 TI - [Transport in blood and mode of action of a hypolipodemic agent related to clofibrate: G P 45.699. Presence in low density serum lipoproteins]. PMID- 4337175 TI - [Determination of penicillanic acid in solutions of penicillins using dithionitrobenzoic acid]. PMID- 4337176 TI - Effects of cutting nervi conarii and tentorium cerebelli on pineal composition and activity shifting following reversal of photoperiod. PMID- 4337177 TI - Effects of estrogen and progesterone on sleep patterns of female rats. PMID- 4337178 TI - The present status of corticotrophin therapy. PMID- 4337179 TI - [Value of synoviorthesis by intra-articular injection of osmic acid in rheumatoid polyarthritis]. PMID- 4337181 TI - [Dubin-Johnson syndrome: ultrastructural data]. PMID- 4337180 TI - [Pulmonary artery thromboses or thromboemboli observed in chronic respiratory insufficiency. Circumstances of the diagnosis]. PMID- 4337182 TI - [Rectoscopic aspects of bilharziasis and parasitologic correlations]. PMID- 4337184 TI - [Professional secrecy and abused children]. PMID- 4337183 TI - [Liver abscess caused by gallbladder rupture during pyocholecystitis]. PMID- 4337185 TI - Meningoencephalocele with associated rare anomalies. PMID- 4337186 TI - [Effect of various types of anesthesia on the cytochrome oxidase of blood leukocytes]. PMID- 4337187 TI - [Malignization of so-called mixed tumors of the parotid gland]. PMID- 4337188 TI - Attentive arousal and excitability of lateral geniculate body in free behaving cats. PMID- 4337189 TI - Psammoma bodies in diffuse toxic goiter. PMID- 4337190 TI - Ultrastructural alterations of endocrine glands in Tay-Sachs disease. PMID- 4337191 TI - Variability at the 5' ends of two plant viruses. PMID- 4337192 TI - Regulation of a thermostable pyrimidine ribonucleoside kinase by cytidine triphosphate. PMID- 4337194 TI - Isolation of the peptide core of costal cartilage chondroitin 4-sulfate proteoglycan. PMID- 4337193 TI - Selective alteration of the regulatory properties of fructose 1,6-diphosphatase by modification with pyridoxal 5'-phosphate. PMID- 4337195 TI - Some effects of environment on the folding of nicotinamide-adenine dinucleotides in aqueous solutions. PMID- 4337197 TI - Cellular localization and characterization of bovine liver branched-chain -keto acid dehydrogenases. PMID- 4337196 TI - Energy-dependent effects on the oxidation-reduction midpoint potentials of the b and c cytochromes in phosphorylating submitochondrial particles from pigeon heart. PMID- 4337199 TI - Synaptic potential summation and repetitive firing mechanisms: input-output theory for the recruitment of neurons into epileptic bursting firing patterns. PMID- 4337198 TI - Arousal effects on cochlear potentials: investigation of a two-factor hypothesis. PMID- 4337200 TI - The synthesis of protein by mammalian RNA viruses. In: strategy of the viral genome. PMID- 4337202 TI - Strategy of simian virus 40. In: strategy of the viral genome. PMID- 4337201 TI - The translation and processing of poliovirus proteins. In: strategy of the viral genome. PMID- 4337203 TI - Enzymes specified by DNA-containing animal viruses. In: strategy of the viral genome. PMID- 4337204 TI - Polyoma gene functions required for cell transformation. In: strategy of the viral genome. PMID- 4337205 TI - Virus-specified proteins and their breakdown products. In: strategy of the viral genome. PMID- 4337206 TI - Adenovirus-specified proteins. In: strategy of the viral genome. PMID- 4337207 TI - Herpes virus-specified proteins. In: strategy of the viral genome. PMID- 4337208 TI - Some enzymes specified by DNA phages. In: strategy of the viral genome. PMID- 4337209 TI - Further characterization of the genetic map of poliovirus temperature-sensitive mutants. In: strategy of the viral genome. PMID- 4337211 TI - Sorbitol dehydrogenase of rat testis: changes of activity during development, after hypophysectomy and following gonadotrophic hormone administration. PMID- 4337210 TI - A steady-state control analysis of the renin-angiotensin-aldosterone system. PMID- 4337212 TI - Studies on luteinization of transplanted rabbit follicles exposed to LH, actinomycin D, or adenosine 3'5'-cyclic-monophosphate in vitro. PMID- 4337213 TI - TSH and ACTH secretion after intrapituitary injection of synthetic TRF. PMID- 4337214 TI - Bromacetyl-oxytocin, an irreversible inhibitor of neurohypophyseal hormone stimulated adenylate cyclase, and a possible affinity label for hormone receptors. PMID- 4337215 TI - The binding of iodinated hCG to porcine granulosa cells. PMID- 4337216 TI - The aerosol stability of a strain of foot-and-mouth disease virus and the effects on stability of precipitation with ammonium sulphate, methanol or polyethylene glycol. PMID- 4337217 TI - The influence of relative humidity on the aerosol stability of different strains of foot-and-mouth disease virus suspended in saliva. PMID- 4337218 TI - Maturation of infectious simian virus 40 in the presence of ethidium bromide. PMID- 4337219 TI - The morphogenesis of pigeonpox virus. PMID- 4337220 TI - The effect of priming with interferon on interferon production by two lines of L cells. PMID- 4337221 TI - Interferon induction: rate of cellular attachment of poly IC. PMID- 4337223 TI - Preparative resolution and identification of synaptic components of rat neocortex. PMID- 4337222 TI - Detection of early cell surface changes in herpes simplex virus infected cells by agglutination with concanavalin A. PMID- 4337224 TI - [A study of the etiology of "Tsuwari" (emesis gravidarum) with special reference to fluctuations of urinary 17-KS fractions in pregnant women with Tsuwari]. PMID- 4337226 TI - [Importance of the association of Nivaline and vitamins of the B group in the treatment of neuropathies]. PMID- 4337225 TI - [Double immunization of rabbits with adenoviruses of subgroups I and 3]. PMID- 4337227 TI - RN's and pharmacists join in fight against drug abuse. PMID- 4337228 TI - "Tertiary" hyperparathyroidism and apparent "cure" of vitamin-D-resistant rickets after removal of an ossifying mesenchymal tumor of the pharynx. PMID- 4337229 TI - Role of hypothalamic monoaminergic neurones in the gonadotrophin release regulating mechanisms. PMID- 4337230 TI - Prostaglandin-induced neurotransmission failure in the field-stimulated, isolated vas deferens. PMID- 4337231 TI - The effect of dexamethasone blockade of ACTH release on avoidance learning. PMID- 4337232 TI - Sleep and wakefulness in female rats during pregnancy. PMID- 4337233 TI - The RNA tumor viruses--background and foreground. AB - The members of the RNA tumor virus (or leukovirus) group of animal viruses replicate via a DNA intermediate and transmit their information stably in cells as DNA. Although some of these viruses are capable of inducing neoplastic transformation, others are not. These viruses may be related to spontaneous neoplasia, but the relationship is that of analogy rather than etiology. The relationship of these viruses to human disease is unknown. Two models of spontaneous neoplasia that involve either activation of the information of a transforming RNA tumor virus or the creation of information for neoplastic transformation by recombination involving information transfer from RNA to DNA are being tested in model systems. PMID- 4337234 TI - Some implications of the activation of murine leukemia virus by halogenated pyrimidines. AB - Genetic information of murine leukemia viruses is known to be present in essentially all mice. Delineation of the biological effects of the expression of this genetic information is complicated by the difficulty in determining whether the presence of a viral antigen in a tissue is the result of gene activation that occurs independently in a large number of cells, proliferation of antigen positive cells, or of spread of infectious virus from a few cells. This problem is further complicated by the difficulty in determining whether activation of virus genetic material is the cause or result of a biological phenomenon, such as malignancy. Further understanding of the activation of virus genes in normal cells is of great importance in answering these questions. In vitro techniques were used for the study of induction of virus. Virus-negative cell lines were established from embryos of AKR mice, which in vivo produce high titers of infectious murine leukemia virus. It was found that 5-iododeoxyuridine and 5 bromodeoxyuridine were potent inducers of virus synthesis in all clones and subclones of the AKR cells tested. In addition to establishing that the complete viral genome is a heritable component of all cells of the AKR mouse, these studies of virus activation provide novel approaches to a number of important problems in the biology of leukemia viruses. PMID- 4337235 TI - Herpesviruses and oncogenesis. AB - Herpesviruses have been implicated in oncogenesis. They have been found to be etiologic agents in certain chicken, primate, and frog neoplasms. There is suggestive evidence that herpesviruses may contribute to the genesis of certain human lymphomas. PMID- 4337236 TI - The question of the primary electron acceptor in bacterial photosynthesis. AB - An electrophoretic purification of Rhodospirillum rubrum photoreceptor subunits prepared by alkaline urea-detergent disruption is described. Completely active photoreceptor subunits with less than 0.30 eq of iron (or any other transition metal) per phototrap can routinely be prepared. A new photoproduced electron paramagnetic resonance (EPR) signal has been detected in these preparations; it was shown to be due to a photoreduced species. It has a g-value of 2.0050 +/- 0.0003, a peak-peak width of 7.0 +/- 0.3 G, and a nearly Gaussian shape. The response of the new signal to microwave power is different from that of the EPR signal of the photoproduced primary electron donor of chromatophores. Quantum yield measurements of spin production show that the new signal is very efficiently formed (varphi = 0.6) simultaneously with the electron donor radical. No hyperfine structure (down to 0.1 G modulation amplitude) was observed in the new signal, either at room temperature or at the temperature of liquid nitrogen. The possible identity of this molecule is discussed. PMID- 4337237 TI - The genome of RNA tumor viruses contains polyadenylic acid sequences. AB - The 70S genome of two RNA tumor viruses, murine sarcoma virus and avian myeloblastosis virus, binds to Millipore filters in buffer with high salt concentration and to glass fiber filters containing poly(U). These observations suggest that 70S RNA contains adenylic acid-rich sequences. When digested by pancreatic RNase, 70S RNA of murine sarcoma virus yielded poly(A) sequences that contain 91% adenylic acid. These poly(A) sequences sedimented as a relatively homogenous peak in sucrose gradients with a sedimentation coefficient of 4-5 S, but had a mobility during polyacrylamide gel electrophoresis that corresponds to molecules that sediment at 6-7 S. If we estimate a molecular weight for each sequence of 30,000-60,000 (100-200 nucleotides) and a molecular weight for viral 70S RNA of 3-12 million, each viral genome could contain 1-8 poly(A) sequences. Possible functions of poly(A) in the infecting viral RNA may include a role in the initiation of viral DNA or RNA synthesis, in protein maturation, or in the assembly of the viral genome. PMID- 4337238 TI - Glucagon-stimulated phosphorylation of mitochondrial and lysosomal membranes of rat liver in vivo. AB - The pancreatic hormone, glucagon, stimulates the net uptake of inorganic (32)P in vivo into rat liver and its incorporation into proteins of microsomes, mitochondrial membranes, and lysosomes. Incorporation into cytosolic proteins was enhanced only slightly by glucagon. More than 95% of the protein-bound phosphate is present as phosphoserine. Both the radioactivity and the total amount of protein-bound phosphate are increased after injection of glucagon. Glucagon treatment enhanced (32)P incorporation into the alcohol-ether soluble lipids of mitochondria but did not alter the relative distribution of (32)P in various phospholipid species. PMID- 4337239 TI - The effect of aldosterone on the accumulation of adenosine 3':5'-cyclic monophosphate in toad bladder epithelial cells in response to vasopressin and theophylline. AB - Vasopressin and theophylline both increase the content of adenosine 3':5'-cyclic monophosphate (cAMP) in epithelial cells of the urinary bladder of toads (Bufo marinus). Incubation of the tissue with 0.2 muM aldosterone markedly increases this response to the two agents; incubation for a similar time without steroid reduces the response. The permeability responses (sodium transport and water flow) of the intact tissue to vasopressin, theophylline, and exogenous cAMP are also considerably greater in bladders incubated with aldosterone than without. The results are interpreted as indicating that the foregoing permissive effects of aldosterone on the permeability responses to vasopressin and theophylline are mediated by a steroid-dependent increase in the accumulation of cAMP in the pertinent epithelial cells, probably as a consequence of a diminution in the rate of degradation of the intracellular nucleotide. PMID- 4337240 TI - Stimulation of release of adrenal catecholamine by adenosine 3':5'-cyclic monophosphate and theophylline in the absence of extracellular Ca 2+ . AB - Stimulation of catecholamine release was studied in the isolated adrenal of the cat during retrograde perfusion. Theophylline, adenosine 3':5'-cyclic monophosphate (cyclic AMP), and dibutyryl-cyclic AMP stimulated catecholamine release in adrenal chromaffin tissue; adenosine, 2'-AMP, 3'-AMP, and 5'-AMP were ineffective. Addition of theophylline for 5-15 min had no effect on catecholamine release induced by KCl or nicotine, but it significantly increased the responses to cyclic AMP and its dibutyryl derivative. Glands perfused with Ca(2+)-free Locke's solution for 30-180 min rapidly lost their responsiveness to KCl or nicotine. In contrast, exposure to Ca(2+)-free medium for 180 min had no effect on secretory responses to either the cyclic nucleotides, themselves, or to methylxanthine-induced potentiation of cyclic AMP responses. Thus, dibutyryl cyclic AMP, cyclic AMP, and theophylline do not require extracellular Ca(2+) to release adrenal catecholamines. They may act by translocating intracellular bound Ca(2+) or by a mechanism independent of calcium. PMID- 4337243 TI - Nitrogen ligands at the active site of alkaline phosphatase. AB - The two Zn(II) ions of native Escherichia coli alkaline phosphatase (EC 3.1.3.1) that are necessary for activity have been replaced by (63)Cu(II). Titration of apoenzyme with up to 2 eq of Cu(II) gives a homogeneous species with an electron spin resonance typical for Cu(II) in an axially symmetric environment, with A(z) = 496 MHz, g(z) = g = 2.27, and g(x) = g(y) = 2.05. At least seven nitrogen hyperfine lines, spaced 11 G apart, are clearly resolved on the M = +[unk] Cu(II) hyperfine peak in the parallel region. When more than 2 eq of Cu(II) are added, the electron spin resonance spectrum shows at least two types of Cu(II) binding sites; the additional site, or sites, are characterized by lower g and higher A(z) values. When Cu(II) is added to native Zn(II) alkaline phosphatase or to apoenzyme incubated with 2 eq of Zn(II), the electron spin resonance spectrum shows little or no trace of the species with higher g values and nitrogen splitting. These results indicate that the species with higher g represents copper bound at the site normally occupied by the 2 Zn (II) ions necessary for enzyme activity, and that the metal ion at this site has at least 3 equivalent nitrogen ligands, probably histidyl side chains. PMID- 4337242 TI - Biological study of a nontoxic, water-soluble immunoadjuvant from mycobacterial cell walls. AB - Whole mycobacterial cells, which are used in Freund's complete adjuvant, besides inducing hypersensitivity to tuberculoprotein, also can elicit hyperreactivity to endotoxins, lymphoid hyperplasia, and allergic polyarthritis in rats. The data reported here demonstrate that a potent water-soluble adjuvant obtained from mycobacterial cell walls is also effective in increasing the immune response to viruses, and that it is free of the toxic effects observed with whole mycobacterial cells. PMID- 4337241 TI - Antiviral activity and side effects of polyriboinosinic-cytidylic acid complexes as affected by molecular size. AB - The decrease of the molecular size of poly(I.C) to less than 10(6) decreases its ability to induce interferon, protect mice against virus, or enhance the immune response. Immune adjuvant activity appeared more sensitive to molecular weight than the other protective activities. The composition of the complex-the molecular size of the individual homopolymers when one was large and the other small-did not affect antiviral activity; the activity of a complex made from large poly(I) and small poly(C) was similar to one made from small poly(I) and large poly(C). Molecular size of the complex did not profoundly alter the side effects of poly(I.C). At 2 mg/kg, none of the complexes markedly altered phagocytic function. Only the largest complex sensitized the mouse to endotoxin. However, all of the complexes studied profoundly inhibited drug metabolism by the liver microsomal enzymes between 24 and 72 hr after their inoculation. Decreasing the molecular weight did not alter this inhibition. PMID- 4337244 TI - Glycolipid synthesis in normal and virus-transformed hamster cell lines. AB - Studies have been continued on the synthesis of glycolipids by the NIL 2 line of hamster cells. Several clones were isolated from this line. These clones vary in morphology, saturation density, and glycolipid composition. Contrary to expectation there was no correlation between saturation density and complexity of the glycolipid pattern. In fact, the clone with the highest saturation density was the only one to show the complete set of glycolipids found previously in NIL 2 cells. All untransformed NIL clones show an increase in the level of "higher" (more than two saccharides/ceramide) glycolipids as the cells approach confluence. In the line containing all three "higher" neutral glycolipids, all three increased as cells approached saturation density. In the line containing only hematoside, this compound increased at confluence. Cells transformed by hamster sarcoma virus or polyoma virus showed no density-dependent glycolipid synthesis. PMID- 4337245 TI - Translation of avian myeloblastosis virus RNA in a cell-free lysate of Escherichia coli. AB - In a cell-free extract of E. coli, RNA from avian myeloblastosis virus directs the synthesis of a protein that is antigenically identical with the group specific antigen 4, and other proteins, three of which correspond in molecular weight to group-specific antigens 1-3. PMID- 4337246 TI - Biochemical physiology of a respiration-deficient mutant of the photosynthetic bacterium Rhodopseudomonas capsulata. AB - Nonsulfur purple photosynthetic bacteria generally possess the adaptive capacity to grow anaerobically (photosynthetically) and aerobically in darkness (energy obtained by respiratory phosphorylation). To develop a test system for study of interactions between the photosynthetic energy-conversion and dark respiration systems and the mechanism by which O(2) inhibits bacteriochlorophyll synthesis, we have isolated a mutant of Rhodopseudomonas capsulata that is incapable of dark aerobic growth. Both the parent strain and the mutant strain Z-1 (aer-13) grow readily anaerobically in the light with either malate or succinate as the source of carbon and reducing power. They differ, however, in that membrane fragments ("chromatophores") from the mutant show severely impaired ability to use reduced nicotinamideadenine dinucleotide (NADH) as a source of electrons for respiration, oxidative phosphorylation, or "redox buffering" of the photophosphorylation system. The results presented indicate that the genetic lesion responsible for greatly diminished capacity to oxidize NADH can account for inability of Rps. capsulata Z-1 (aer-13) to grow aerobically in darkness. PMID- 4337247 TI - Protein synthesis in Simian virus 40-infected monkey cells. AB - The proteins of purified Simian virus 40 (SV40) were examined by sodium dodecyl sulfate-acrylamide gel electrophoresis and compared with the polypeptides synthesized in SV40-infected monkey cells. Purified virions contain two major components, with molecular weights of 44,000 and 31,000. Together they make up 83% of the total virion proteins. In addition, the virus contains 12 minor polypeptides, which are believed to be cellular proteins, or peptides derived from proteolytic degradation of the 44,000 molecular weight polypeptide. Pulse label experiments show that about 90% of the polypeptides synthesized after SV40 infection are host-cell proteins; 10% represent the two major structural components of the virion. A small fraction (about 0.5%) consists of three polypeptides (molecular weights 70,000, 60,000, and 8,000) that are neither part of the virion nor detectable in uninfected cells. They are either virus-induced cellular proteins or, more likely, proteins coded for by the SV40 genome. PMID- 4337248 TI - Neoplastic transformation in vitro of a clone of adult liver epithelial cells into differentiated hepatoma-like cells under conditions of nutritional stress. AB - Differentiated epithelial cells in contact-inhibited monolayers derived from adult rat liver have been transformed in vitro into epithelioid neoplastic cells under conditions of nutritional stress. The transformed cells maintain their differentiated quality and manufacture serum proteins. They differ from control cultures in the following properties: They are aneuploid, can be agglutinated by wheat-germ agglutinin and concanavalin A, can grow in suspension, and are able to form colonies in semisoft agar. There is no intercellular communication at permeable junctions between the cells; this is demonstrable by electrical measurement or by injection of fluorescein. The cells show invasiveness in culture, and are not inhibited by contact with normal cells. The characteristics of the hepatocytes after transformation in vitro resemble those of epithelioid cells derived from a transplantable hepatoma. PMID- 4337249 TI - Study of adrenocorticotropic hormone conformation by evaluation of intramolecular resonance energy transfer in N -dansyllysine 21 -ACTH-(1-24)-tetrakosipeptide. AB - The solution conformation of ACTH was studied by intramolecular resonance energy transfer and fluorescence depolarization with the synthetic, biologically active, derivative N(epsilon)-dansyllysine(21)-ACTH-(1-24)-tetrakosipeptide. The Forster parameters involved in energy transfer from the donor Trp(9) to the dansyl acceptor attached to the side chain of Lys(21) were determined from measurements with ACTH fragments containing either the donor or the acceptor alone. From determinations of the fluorescence quantum yields of the donor in the derivative and in the native ACTH-(1-24)-tetrakosipeptide, it was shown that besides energy transfer no additional quenching of the donor fluorescence is introduced by the presence of the acceptor. The short measured rotational relaxation time of the dansyl chromophore reflects the flexibility of the lysine side chain and justifies the use of an average value for the orientation factor in the distance calculations. The calculated intramolecular distance is remarkably independent of solvent, indicating a "random coil" situation with regard to residues 9-21. PMID- 4337251 TI - Management of headache by the family physician. PMID- 4337250 TI - Schizophrenics anonymous: a treatment adjunct. PMID- 4337252 TI - [Evolution of corticotropic formation, in the green frog, Rana esculenta L., after ectopic transplantation of the distal lobe of the hypophysis]. PMID- 4337253 TI - [Electron microscope study of the Leydig cell in the normal man]. PMID- 4337254 TI - [Electron microscope study of the Leydig cell in Klinefelter's disease in pre, per- and post-pubertal periods]. PMID- 4337255 TI - [Idiopathic hypophyseal insufficiency in the child. Study of 30 cases]. PMID- 4337257 TI - Polymyxin B. NMR evidence for a peptide antibiotic with folded structure in water. PMID- 4337256 TI - Comparative polyacrylamide electrophoresis of periplasmic proteins released from gram-negative bacteria by polymyxin B. PMID- 4337258 TI - Experience with plastic lower extremity orthoses. PMID- 4337259 TI - Poland's syndrome. Report of seven cases and review of the literature. PMID- 4337260 TI - Glucosamine 6-phosphate synthesis in normal and neoplastic rat tissues. PMID- 4337261 TI - Occurrence and particle character of aminoacyl-tRNA synthetases in the post microsomal fraction from rat liver. PMID- 4337262 TI - The oxidation of malate by isolated plant mitochondria. PMID- 4337263 TI - [The kinetics of marking nucleolar proteins. Demonostration of a rapidly marked fraction]. PMID- 4337264 TI - Study of the interaction of soluble and particle-bound nicotinamide adenine dinucleotide pyrophosphorylase with cytoplasmic ribosomes. PMID- 4337265 TI - Cyclic 3':5' AMP and cell proliferation in cultures of embryonic rat cells. PMID- 4337266 TI - Synthesis of coagulation factors by a clonal strain of rat hepatoma cells. PMID- 4337267 TI - [Action of phytohemagglutinins on normal and tumour cell growth]. PMID- 4337269 TI - The effects of technical chlordane on energy metabolism of Bacillus subtilis. PMID- 4337268 TI - Inactivation of glucagon by plasma membranes of rat liver. PMID- 4337270 TI - The effects of technical chlordane on growth and energy metabolism of Streptococcus faecalis and Mycobacterium phlei: a comparison with Bacillus subtilis. PMID- 4337271 TI - Peripheral neuropathy in chronic liver disease: clinical, electrodiagnostic, and nerve biopsy findings. AB - In a prospective study of 70 unselected patients with chronic liver disease, clinical signs of a peripheral neuropathy were observed in 13 patients. Abnormal nerve conduction was demonstrated in nine of these and in one further patient who had no abnormal neurological signs. The occurrence of a neuropathy (in patients with cryptogenic cirrhosis, haemochromatosis, active chronic hepatitis as well as in alcoholic cirrhosis) could not be related to liver function, although it was associated with higher IgA and IgM values. Clinical diabetes was present in six of the 14 patients with neuropathy but there was no relation in the non-diabetic patients between neuropathy and minor impairment of carbohydrate tolerance. Those with neuropathy had a significantly higher incidence of oesophageal varices and there was also a relationship to a history of previous encephalopathy. Sural nerve biopsy was carried out on 14 patients, eight of whom had clinical or electrodiagnostic evidence of neuropathy. Single nerve fibres were examined by teasing and in all nerves histological evidence was found of an indolent process which had damaged whole Schwann cells and which resulted in demyelination and remyelination. Diabetic angiopathy was not seen and axonal degeneration, which was never severe, was found in all disease groups equally. PMID- 4337273 TI - Melanotic progonoma of the skull. AB - A case of progonoma of the skull in a 7 month old boy is described. The various theories as to the histogenesis of this rare tumour are reviewed. PMID- 4337272 TI - Transmission block in terminal nerve twigs: a single fibre electromyographic finding in man. AB - Single fibre electromyography has been performed in patients with partial nerve lesions, amyotrophic lateral sclerosis, progressive spinal muscle atrophy, muscular dystrophy, and distal hereditary myopathy. The recorded action potentials were often more complex than in the normal muscle due to increased fibre density in the motor unit and the individual spike components showed a large jitter and occasional blockings. Sometimes two or more spikes in a complex disappeared and reappeared simultaneously upon successive discharges. This phenomenon, called 'paired blocking', has been further investigated. The jitter of the blocking potentials in relation to the rest of the complex was large, up to 500 MUsec. The degree of blocking increased with increasing innervation frequency until it eventually proceeded to total block during continuous activity. Sometimes a slight effect on blocking was seen after edrophonium. This type of block is probably localized in the terminal nerve twigs, perhaps in newly formed sprouts. The phenomenon of neurogenic blocking may contribute to the fatigue clinically experienced in different denervation-reinnervation cases. PMID- 4337274 TI - Neuropathologic study of fourteen cases of malignant brain tumor treated by boron 10 slow neutron capture radiation. PMID- 4337275 TI - Cytoplasmic inclusions in a child affected with Krabbe's disease (globoid leucodystrophy) and in the rabbit injected with galactocerebrosides. PMID- 4337276 TI - Epstein-Barr virus in infancy. PMID- 4337277 TI - Prospective study of Epstein-Barr virus infections in acute lymphoblastic leukemia of childhood. PMID- 4337278 TI - A study of the renin-angiotensin system in newborn infants. PMID- 4337279 TI - Correlation of performance in track and field events with bone age. PMID- 4337280 TI - Thyroid in the treatment of short stature. PMID- 4337282 TI - [Experiences with transantro-sphenoidal pituitary surgery in acromegaly]. PMID- 4337281 TI - [Neurosurgical and rhinologic co-operation in surgery of the skull basis]. PMID- 4337283 TI - [Standard for bone age determination based on x-ray findings of the hand]. PMID- 4337284 TI - [Management of so-called cubital tunnel syndrome. 2]. PMID- 4337285 TI - [Cases of peripheral nerve paralysis due to pressure--contusion of the elbow joint region]. PMID- 4337286 TI - Disruptive effects of rapid eye movement sleep deprivation on long-term memory. PMID- 4337287 TI - Effects of hypovolemia and-or caval ligation on water and NaCl solution drinking by rats. PMID- 4337288 TI - Long-stay psychiatric inpatients: a study based on the Camberwell register. PMID- 4337289 TI - Thalamocortical relay neurons: antidromic invasion of spikes from a cortical epileptogenic focus. AB - Thalamocortical relay neurons whose axons project into a penicillininduced cortical epileptogenic focus generate bursts of action potentials during spontaneous interictal epileptiform discharges. These bursts originate in intracortical axons and propagate antidromically into thalamic neurons. Repetitive spike generation in cortical axons and presynaptic terminals could produce a potent excitatory drive and contribute to the generation of the large depolarization shifts which are seen in cortical elements during focal epileptogenesis. PMID- 4337290 TI - Management of infections in patients with leukemia and lymphoma: current concepts and experimental approaches. PMID- 4337292 TI - [Tumors of the parotid gland in children]. PMID- 4337293 TI - [Melanoameloblastoma]. PMID- 4337291 TI - Experience in liver transplantation. PMID- 4337294 TI - [The morphology of pancreatic islet cells following experimentally induced blood pressure dysregulation in rats]. PMID- 4337295 TI - Brush biopsy of bronchial carcinoid--a source of cytologic error. PMID- 4337296 TI - Nursing neuropathy. An easily remedied problem of the nursing mother. PMID- 4337297 TI - Goltz's syndrome. PMID- 4337299 TI - Fulminant hepatitis due to herpes hominis in an adult human. PMID- 4337298 TI - Acromegaly in a 9 and one-half-year-old boy. Pituitary function studies before and after surgery. PMID- 4337301 TI - A method for the culture of Lichen thalli under controlled conditions. PMID- 4337300 TI - Watery diarrhea and hypokalemia due to nonbeta-islet cell hyperplasia of the pancreas. PMID- 4337302 TI - Binding of 14 C-penicillin G to Proteus mirabilis. PMID- 4337303 TI - Seizure occurrence and interspike interval. Telemetered electroencephalogram studies. PMID- 4337304 TI - Thallium poisoning. PMID- 4337305 TI - Prognosis of idiopathic Bell's palsy. PMID- 4337306 TI - [Effect of oxazepam on day sleep disturbed by night work]. PMID- 4337307 TI - Control of Marek's disease in the Netherlands. I. Isolation of an avirulent Marek's disease virus (strain CVI 988) and its use in laboratory vaccination trials. PMID- 4337308 TI - Selection for resistance to Marek's disease and its expected effects on other important traits in white leghorn strain crosses. PMID- 4337309 TI - Control of Marek's disease in the Netherlands. II. Field trials on vaccination with an avirulent strain (CVI 988) of Marek's disease virus. PMID- 4337311 TI - The use of blood from selected chickens as an immunizing agent for Marek's disease. PMID- 4337310 TI - Maternal transfer of resistance against development of Marek's disease tumors. PMID- 4337313 TI - Future research on the control of Marek's disease. PMID- 4337312 TI - Commercial applications of present alternatives for control of Marek's disease. PMID- 4337314 TI - Marek's disease vaccine: its implications in biology and medicine. PMID- 4337315 TI - Preliminary observations on egg transmission of turkey herpesvirus (HVT) in turkeys. PMID- 4337316 TI - Selection for resistance to Marek's disease in conjunction with other economic traits in chickens. PMID- 4337317 TI - Experimental infection of turkeys and chickens with a herpesvirus of turkeys (HVT). PMID- 4337318 TI - Long-term field trials with the herpesvirus of turkeys vaccine against Marek's disease. PMID- 4337319 TI - Prophylactic efficacy of a Marek's disease vaccine in broiler and replacement layer chickens. PMID- 4337320 TI - Attenuated Marek's disease herpesvirus: protection conferred on strains of chickens varying in genetic resistance. PMID- 4337321 TI - ATP(Mg 2+ ) induced inhibition of cyclic AMP reactivity with a skeletal muscle protein kinase. PMID- 4337322 TI - Premature induction of pepsinogen in developing rat gastric mucosa by hormones. PMID- 4337323 TI - Non-participation of aminoacyl adenylates in the spermine catalyzed aminoacylation of transfer-RNA. PMID- 4337324 TI - Na + -dependent amino acid transport in isolated membrane vesicles of a marine pseudomonad energized by electron donors. PMID- 4337325 TI - Magnetic resonance studies of the anomeric distribution and manganese binding properties of fructose phosphates. PMID- 4337326 TI - Isolation and characterization of two acidic proteins from the 50S subunit required for GTPase activities of both EF G and EF T. PMID- 4337327 TI - Interaction between proflavine and deoxyribonucleic acid influence of DNA base composition. PMID- 4337328 TI - Colorimetric determination of ACTH. PMID- 4337329 TI - Some thermodynamic data on D-glyceraldehyde-3-phosphate dehydrogenase action under optimal conditions. PMID- 4337330 TI - Preparation and physicochemical properties of green pea superoxide dismutase. PMID- 4337331 TI - Purification and properties of D-pantothenate kinase from rat liver. PMID- 4337332 TI - Properties of polyphosphate kinase prepared from mycobacterium smegmatis. PMID- 4337333 TI - Polyguanylic acid-inhibited ribonuclease of Klebsiella. I. Purification and general properties. PMID- 4337334 TI - Phytase and alkaline phosphatase activities in intestinal mucosae of rat, chicken, calf, and man. PMID- 4337335 TI - Avian fructose-1,6-diphosphatases. I. Purification and comparison of physical and immunological properties of the liver and breast muscle enzymes from chicken (Gallus domesticus). PMID- 4337336 TI - Uridine diphosphate N-acetyl-D-glucosamine-2-epimerase from rat liver. I. Catalytic and regulatory properties. PMID- 4337337 TI - Subcellular localization of acid hydrolases in rat lungs. PMID- 4337338 TI - Dissociation of nuclear DNA replication from concomitant protein synthesis in synchronous cultures of Chlorella. PMID- 4337339 TI - A quantitative study of binding of glycine-arginine rich histone to DNA. PMID- 4337340 TI - Rat liver nuclear ribonucleoprotein particles: reassociation of residues with various types of RNA. PMID- 4337341 TI - Endoribonuclease activity associated with nucleolar ribonucleoprotein particles from Novikoff hepatoma. PMID- 4337342 TI - A screening procedure for detecting and characterizing hyperlipoproteinemia. PMID- 4337344 TI - A method for the quantitative determination of the abnormal lipoprotein (LP X) of obstructive jaundice. PMID- 4337343 TI - An association of very low density lipoproteins with type II hyperlipoproteinaemia. PMID- 4337345 TI - St 1 -anti-st 1 : a new human autoimmune system. PMID- 4337346 TI - Delta-9-tetrahydrocannabinol and synhexl: effects on human sleep patterns. PMID- 4337347 TI - [Odontodysplasia. A case of asymmetric hypoplasia of the left maxillary quadrant in both dentitions]. PMID- 4337348 TI - Effect of depolarizing agents on accumulation of cyclic adenosine 3',5' monophosphate in cerebral cortical slices. PMID- 4337349 TI - 6-Hydroxydopamine, a new oxidation mechanism. PMID- 4337350 TI - Intracellular study of seizure-like afterdischarges elicited in thin hippocampal sections in vitro. PMID- 4337352 TI - Relationship of spontaneous vagal activity to wakefulness and sleep in the cat. PMID- 4337351 TI - The effects of bicuculline on the isolated spinal cord of the frog. PMID- 4337353 TI - Erythrocyte NADH-methemoglobin reductase activity in experimental riboflavin deficiency. PMID- 4337355 TI - Spontaneous transmitter release from nerve endings and contractile properties in the soleus and diaphragm muscles of senile rats. PMID- 4337354 TI - The interaction of angiotensin with a binding factor in plasma. PMID- 4337356 TI - The effect of cyclic N-2-O-dibutyryl-adenosine-3',5'-monophosphate on neuromuscular transmission and concentration of glycogen in the isolated phrenic nerve-diaphragm preparation of the rat. PMID- 4337357 TI - Pancreatic islet cell damage in mice produced by coxsackie B 1 and encephalomyocarditis viruses. PMID- 4337358 TI - Crystalloid inclusions in the connective tissue of spider venom gland. PMID- 4337359 TI - Collagenase associated with macrophage and giant cell activity. PMID- 4337360 TI - Expression of differentiated functions in hepatoma cell hybrids. II. Aldolase. PMID- 4337361 TI - Induction of erythroblast increase in rabbit marrow cells by extracts of leukocytes and certain metabolic compounds. IV. Studies on erythropoiesis. PMID- 4337362 TI - Cerebellopontine angle myelography. PMID- 4337363 TI - [Cyclic AMP. Method of study. Activity level. Mechanism of action]. PMID- 4337364 TI - [Electrogustometry]. PMID- 4337365 TI - [Low temperature storage of transplantable tumor cells]. PMID- 4337366 TI - [Circadian rhythm of the hypothalamo-pituitary-adrenal system]. PMID- 4337367 TI - [Decidual reaction of the cervix muscosal stroma during pregnancy]. PMID- 4337368 TI - Effect of interferon treatment on the tumour-specific antibody response of BALB-c mice infected with Rauscher virus. PMID- 4337369 TI - Future shock--a present reality in pathology. Ward Burdick Award address. PMID- 4337370 TI - Adenoviruses. PMID- 4337371 TI - Practical considerations in the diagnosis of myxovirus infections. PMID- 4337372 TI - Tissue culture in the laboratory diagnosis of viral infections. PMID- 4337373 TI - Application of the immunofluorescent technic to the study of pathogenesis and rapid diagnosis of viral infections. PMID- 4337374 TI - Panel discussion: laboratory diagnosis of viral infections--recent advances and their clinical application. PMID- 4337375 TI - Early observations on cytopathogenicity of poliovirus. PMID- 4337376 TI - Decreased cyclic AMP in the epidermis of lesions of psoriasis. PMID- 4337377 TI - Xanthomatosis and lymphedema. PMID- 4337378 TI - Familial reticuloendotheliosis with eosinophilia and follicular mucinosis. PMID- 4337379 TI - Action of glucagon on -amylase and some other enzymes involved in glycogen breakdown. PMID- 4337380 TI - Comparison of adrenergic mechanisms in an elastic and a muscular artery of the rabbit. PMID- 4337381 TI - Quantification of intermediate steps in the renin-angiotensin-vasoconstrictor feedback loop in the dog. PMID- 4337382 TI - Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. PMID- 4337383 TI - Optimal conditions for the kinetic assay of serum glutamate dehydrogenase activity at 37 degrees C. PMID- 4337384 TI - Radioimmunoassay of angiotensin I: comparison of two renin activity methods and use for other measurements of the renin system. PMID- 4337385 TI - Characterization of electrophoretic lipoprotein fractions: immunochemical and electron microscopic studies. PMID- 4337386 TI - Differential diagnosis of nonspecific and amebic ulcerative colitis: survey of 100 patients. PMID- 4337387 TI - Submicroscopic cytodifferentiation. PMID- 4337388 TI - Detection of chicken sarcoma virus after transfection of chicken fibroblasts with DNA isolated from mammalian cells transformed with Rous Virus. PMID- 4337389 TI - Induction of mouse tumours by means of virogenic rat tumour cells contining non infectious Rous sarcoma virus genome. PMID- 4337390 TI - Synopsis of mammo-renal syndromes. PMID- 4337391 TI - Distamycin A inhibition of Epstein-Barr virus replication in arginine-deprived Burkitt lymphoblasts. PMID- 4337392 TI - Metabolism of 1,2 H 3 -4-C 14 -cholecalciferol in normal, uremic and anephric subjects. PMID- 4337393 TI - Oxido-reduction of glyoxylate from crystalline lactate dehydrogenase from rabbit muscle. PMID- 4337394 TI - Phospholipase C from Clostridium perfringens: purification by electrophoresis on acrylamide-agarose gel. PMID- 4337395 TI - Reversible resolution of glutamate decarboxylase from Clostridium perfringens. PMID- 4337396 TI - A cancer challenge--the will to conquer. A case report. PMID- 4337397 TI - Ultrastructural effects of calcitonin on osteoclasts in tissue culture. PMID- 4337398 TI - Ultrastructure of rat ovarian interstitial cells. I. Normal structure and regressive changes following hypophysectomy. PMID- 4337399 TI - Ultrastructure of rat ovarian interstitial cells. II. Response to gonadotropin. PMID- 4337401 TI - Stomatal structure in corn leaves. PMID- 4337400 TI - Phagocytosis of latex beads by epidermal keratinocytes in vivo. PMID- 4337402 TI - Maxillary sinus malignancy. PMID- 4337403 TI - Nasopharyngeal malignancies in children. PMID- 4337405 TI - [Pair-grouping of patients suffering from chronic nonspecific lung disease, receiving or not receiving social medical after-care]. PMID- 4337404 TI - Acute mastoiditis following pseudomonas maltophilia infection: case report. PMID- 4337406 TI - The partial hospital as a transition from inpatient treatment: a controlled follow-up study. PMID- 4337407 TI - Paget's carcinoma of the breast. PMID- 4337408 TI - Appetitive acquisition and extinction effects with exogenous ACTH. PMID- 4337409 TI - Hypothalamic sensitivity to 2-deoxy-D-glucose and glucose: effects on feeding behavior. PMID- 4337410 TI - [Calcium absorption from the intestinal tract]. PMID- 4337412 TI - 1971 Nobel Prize for physiology and medicine. PMID- 4337411 TI - Modification by psychotropic drugs of the cyclic AMP response to norepinephrine in the rat brain in vitro. PMID- 4337413 TI - [Role of scintigraphy in the diagnosis of pancreatic diseases]. PMID- 4337415 TI - [Development of freshly isolated shigellae and salmonellae in a cell culture]. PMID- 4337414 TI - [Determination of collagen peptidases in animal tissues]. PMID- 4337416 TI - [The presence of a substance complementary to the agglutinogen of B. pertussis in the serum of normal mice]. PMID- 4337417 TI - [The kinetics of the formation and morphology of B. pertussis spheroplasts]. PMID- 4337418 TI - [The phagocytic activity and some cytochemical changes in leukocytes in infectious diseases]. PMID- 4337419 TI - Relation of bicarbonate to sodium reabsorption in dog kidney. PMID- 4337420 TI - On drug use as a coping strategy: a reply by Gove. PMID- 4337421 TI - 'Integration' of polyoma virus DNA into mammalian genomes. PMID- 4337423 TI - Binding of triphosphate spin labels to hemoglobin Kempsey. PMID- 4337422 TI - Auxin and cyclic 3',5'-adenosine monophosphate during the isolation of chromatin from Avena coleoptiles: effects on cell free RNA synthesis. PMID- 4337424 TI - Regulation of the UDP-glucose-4-epimerase activity in Chinese hamster cells. PMID- 4337425 TI - High and low molecular weight forms of pancreatic cholesterol esterase. PMID- 4337426 TI - Uncoupling of photophosphorylation by ATP: removal of coupling factor. PMID- 4337427 TI - The fraction of the lipid in a biological membrane that is in a fluid state: a spin label assay. PMID- 4337428 TI - Evidence for and some properties of a 3', 5'-cyclic AMP phosphodiesterase inhibitor in potato. PMID- 4337429 TI - Purification of 15-hydroxy prostaglandin dehydrogenase from bovine lung. PMID- 4337430 TI - Kinetic determination of malate dehydrogenase activity eliminating problems due to spontaneous conversion of oxaloacetate to pyruvate. PMID- 4337432 TI - Isoelectric heterogeneity of human serum high-density of lipoproteins. PMID- 4337431 TI - Automatic extraction and analysis of serum triglycerides. PMID- 4337433 TI - Survival, growth and the metabolic response to cold in prematurely delivered lambs. PMID- 4337434 TI - A contribution to the evolutionary theory of dreaming: an hypothesis on the role of the pineal in species and specimen protection. PMID- 4337435 TI - Norepinephrine mediated cerebellar synapses: a model system for neuropsychopharmacology. PMID- 4337436 TI - Glutamate decarboxylase in the rat hippocampal region after lesions of the afferent fibre systems. Evidence that the enzyme is localized in intrinsic neurones. PMID- 4337437 TI - On the catecholamine innervation of the hypothalamus, with special reference to the median eminence. PMID- 4337438 TI - A test of sleep staging systems in the unrestrained chimpanzee. PMID- 4337439 TI - Strychnine-sensitive inhibition in the medullary reticular formation: evidence for glycine as an inhibitory transmitter. PMID- 4337441 TI - Ontogenic changes in cerebral concentration of homovanillic acid in response to haloperidol treatment. PMID- 4337440 TI - 2',3'-cyclic nucleotide 3'-phosphodiesterase in the nervous system. Electrophoretic properties and developmental studies. PMID- 4337442 TI - A light and electron microscopic study of rat anterior pituitary in organotypic tissue culture. PMID- 4337443 TI - The long-lasting effects of cutaneous and high threshold muscle afferent volleys on semitendinosus -motoneurones. PMID- 4337444 TI - Sleep during perceptual deprivation. PMID- 4337445 TI - Effects of a fungus tremorgenic toxin (penitrem A) on transmission in rat phrenic nerve-diaphragm preparations. PMID- 4337446 TI - On the control of brain serotonin turnover rate by end product inhibition. PMID- 4337447 TI - Microelectrophoresis of 5-hydroxytryptamine: a clarification of its action on cerebral cortical neurones. PMID- 4337449 TI - [Significance of the nature of increase in physical loading for adaptation to intensive muscular activity]. PMID- 4337448 TI - Enzymehistochemical studies on the pancreatic islets in mice injected with anti insulin serum. PMID- 4337450 TI - The effects of chronic denervation on spindle discharge patterns and morphology in isolated costocutaneous muscles of garter snakes. PMID- 4337451 TI - Aphasia therapy: a new look. PMID- 4337452 TI - [Malignant tumors in infancy and childhood]. PMID- 4337453 TI - Increased specificity of liver scanning with the use of 67 gallium citrate. PMID- 4337455 TI - [Hypocalcemic effect of glucagon in a 17-month-old child with hypercalcemia]. PMID- 4337456 TI - [Total reconstruction of the breast after the removal of a bilateral giant fibroadenoma]. PMID- 4337454 TI - Further concepts in gustatory sweating. PMID- 4337457 TI - Cystosarcoma phyllodes metastasizing as a mixed mesenchymal sarcoma. PMID- 4337458 TI - Plasma testosterone level in cocks and hens. PMID- 4337459 TI - Ultrastructural changes in heart muscle associated with anaphylaxis in the guinea pig. PMID- 4337460 TI - Effect of hemorrhage-induced hypotension on adrenocortical responsiveness to adrenocorticotrophin. PMID- 4337461 TI - [Neoplasms in canine mammary glands]. PMID- 4337462 TI - [Sensitivity of the vascular system to angiotensin II and 1-norepinephrine before and after hemodialysis]. PMID- 4337463 TI - Attempt to produce animals devoid of mast cells. PMID- 4337464 TI - [Neurotically induced hypertensive blood pressure reactions and the effect of additional interventions into the intermeshed regulatory system of blood pressure homeostasis in albino rats]. PMID- 4337465 TI - [The influence of intraventricularly administered angiotensin II, bradykinin and eledoisin on arterial blood pressure, respiration and electrocardiogram]. PMID- 4337466 TI - Neonatal hepatitis and cytomegalovirus. PMID- 4337467 TI - Etiologic factors in neonatal hepatitis. A preliminary report of a regional survey. PMID- 4337468 TI - Electron microscopy of the liver in infectious mononucleosis hepatitis and cytomegalovirus hepatitis. PMID- 4337469 TI - Electron microscopy studies of severe virus hepatitis. Cytoplasmic inclusions, virus-like particles, Australia antigen. PMID- 4337470 TI - Virus-like particles in the cytoplasm of the livers of Australia antigen carriers. PMID- 4337471 TI - The large particle of Australia antigen. PMID- 4337472 TI - Frequency of Australia antigen in Chinese patients in Singapore with hepatocellular carcinoma. PMID- 4337473 TI - Australia antigen in urine and feces. PMID- 4337475 TI - A viewpoint concerning the enigma of hypertension. PMID- 4337474 TI - Arterial pressure regulation. Overriding dominance of the kidneys in long-term regulation and in hypertension. PMID- 4337476 TI - Physiologic characteristics of hypertension. PMID- 4337479 TI - Inclusion bodies of the epithelium of the urinary bladder in the rhesus monkey. PMID- 4337477 TI - Renin, angiotensin and aldosterone system in pathogenesis and management of hypertensive vascular disease. PMID- 4337478 TI - Renin in anephric man. Case report with physiologic studies. PMID- 4337480 TI - Lymphocyte inclusions. PMID- 4337481 TI - First- and second-degree A-V heart block with rapid eye movement sleep. PMID- 4337483 TI - [Possibilities and limits of vaccination with turkey herpes virus against Marek's disease]. PMID- 4337482 TI - Immunopathologic study of sural nerves in rheumatoid arthritis. PMID- 4337484 TI - Influence of the furanose on the conformation of adenine dinucleoside monophosphates in solution. PMID- 4337485 TI - Translation of satellite tobacco necrosis virus ribonucleic acid. II. Initiation of in vitro translation in procaryotic and eucaryotic systems. PMID- 4337486 TI - Synthesis and turnover of Euglena gracilis nuclear and chlorplast deoxyribonucleic acid. PMID- 4337487 TI - Determination of the h-protein in transformable and transformed cells in culture. PMID- 4337488 TI - Biosynthesis of echinulin. Isoprenylation of cyclo-L-alanyl-L-tryptophanyl. PMID- 4337490 TI - Properties of the apoprotein and role of copper and zinc in protein conformation and enzyme activity of bovine superoxide dismutase. PMID- 4337489 TI - Release of macromolecules from BALB-c mouse cell lines treated with chelating agents. PMID- 4337491 TI - Studies of the metal sites of copper proteins. Symmetry of copper in bovine superoxide dismutase and its functional significance. PMID- 4337492 TI - Use of gas chromatography in periodate oxidation studies of glycopeptides and related materials. PMID- 4337493 TI - Regulation of rat placental phosphorylase. PMID- 4337494 TI - The specificity of aquocobalamin-binding to bovine serum albumin. PMID- 4337495 TI - Effects of chlorpromazine and filipin on the synthesis of corticosterone and stability of lysosomes and mitochondria in the rat adrenal. PMID- 4337496 TI - A neural circuit which exhibits some features of epileptic attacks. PMID- 4337497 TI - [Comparative studies on plasma catecholamine levels in local anesthesia with and without addition of sympathomimetics]. PMID- 4337499 TI - [Unusual aspects of the audiometric curve in liver disease patients and their interpretation]. PMID- 4337500 TI - Endogenous and exogenous smiling systems in early infancy. PMID- 4337498 TI - [Regulatory action of thyroid hormone in protein synthesis]. PMID- 4337501 TI - Regulation of the gal operon of Escherichia coli by the capR gene. PMID- 4337502 TI - Studies on microsomal nucleoside diphosphatase of rat hepatocytes. Its purification, intramembranous localization, and turnover. PMID- 4337503 TI - Histidine regulation in Salmonella typhimurium. 13. Nucleotide sequence of histidine transfer ribonucleic acid. PMID- 4337504 TI - The effects of fasting, refeeding, and time of day on the levels of enzymes effecting the conversion of -hydroxy- -methylglutaryl-coenzyme A to squalene. PMID- 4337505 TI - Structural changes induced by substrates and anions at the active site of creatine kinase. Electron paramagnetic resonance and nuclear magnetic relaxation rate studies of the manganous complexes. PMID- 4337507 TI - Adenylate cyclase activity in adrenocorticotropic hormone-sensitive and mutant adrenocortical tumor cell lines. PMID- 4337506 TI - Sodium-potassium-activated adenosine triphosphatase. VII. Concurrent inhibition of NA + -K + -adenosine triphosphatase and activation K + -nitrophenylphosphatase activities. PMID- 4337508 TI - Nucleotide sequence of 4.5 S ribonucleic acid of Novikoff hepatoma cell nuclei. PMID- 4337510 TI - Phosphoprotein phosphatases from rat cerebral cortex. Subcellular distribution and characterization. PMID- 4337509 TI - The regulation of gluconeogenesis in isolated rat liver cells by glucagon, insulin, dibutyryl cyclic adenosine monophosphate, and fatty acids. PMID- 4337511 TI - Steroid estrogen glycosides. Formation of glucosides and galactosides by human liver and kidney. PMID- 4337512 TI - Deoxyribonucleic acid synthesis in cell-free extracts. 3. Catalytic properties of deoxyribonucleic acid polymerase II. PMID- 4337513 TI - Structural analysis of nucleolar precursors of ribosomal ribonucleic acids. Sequence analysis of long oligonucleotides produced by T 1 ribonuclease digestion of nucleolar and ribosomal 28 S ribonucleic acid of Novikoff hepatoma ascites cells. PMID- 4337514 TI - A comparison of the x-ray diffraction patterns of crystals of reconstituted nuclease-T and of native staphylococcal nuclease. PMID- 4337515 TI - The Senograph: new tool for cancer detection. PMID- 4337516 TI - Aspects in renal physiology. PMID- 4337517 TI - Severe reaction from tetracosactrin. PMID- 4337518 TI - Hypoglycemia presenting with neuropsychiatric symptoms. PMID- 4337519 TI - [Burkitt's tumors]. PMID- 4337521 TI - [Ossification characteristics of the wrist and distal part of the forearm and their significance in the determination of age]. PMID- 4337520 TI - [Swelling of the parotid region, its surgical treatment. Report of 56 cases]. PMID- 4337522 TI - [Treatment of malignant synovioma]. PMID- 4337523 TI - [Experimental adenovirus infection in cricetine hamsters. I. Virological study of course of infection]. PMID- 4337524 TI - [Mechanisms of formation and penetration into the cell of mouse leukemia viruses]. PMID- 4337525 TI - [Use of synthetic inhibitors of neuraminidase and hemagglutinin for studying the functional role of active subunits of membranes of myxo- and paramyxoviruses]. PMID- 4337526 TI - [Localization of transcriptive and replicative intermediate forms of Sendai virus RNA in cell structures]. PMID- 4337527 TI - Ms. and M.D. PMID- 4337528 TI - Audiologic evaluation in cochlear versus retrocochlear lesions. PMID- 4337529 TI - Studies of diabetic glomerulosclerosis using an immunofluorescent technique. PMID- 4337530 TI - The ultrastructure of human and murine astrocytes and of human fibroblasts in culture. PMID- 4337532 TI - Preparation of transfer ribonucleic acid with silicic acid. PMID- 4337533 TI - Studies of oxidative energy deficiency. I. Achondroplasia in the rabbit. PMID- 4337531 TI - Release of monoamines evoked by field stimulation--studies on some ionic and metabolic requirements. PMID- 4337534 TI - Heme-heme interaction in cytochrome c oxidase in situ as measured by EPR spectroscopy. PMID- 4337536 TI - Function and properties of aminoacyl transferase II. II. Subcellular distribution during asynchronous and synchronous growth. PMID- 4337535 TI - The binding of Cu 2+ to actin without loss of polymerizability: the involvement of the rapidly reacting -SH group. PMID- 4337537 TI - Study RNA extracted from HeLa cell polysomes. Isopycnic centrifugation of cytoplasmic particles extracted from normal, poliovirus-infected HeLa cells and mouse A9 cells. PMID- 4337539 TI - Redox properties of liver cytochrome P-450. PMID- 4337538 TI - Effect of (NH 4 ) SO 4 and glycerol on the preservation of the "NAD + independent" activity of D-glucose-6-phosphate, L-myo-inositol-1-phosphate cycloaldolase from Neurospora crassa. PMID- 4337541 TI - The localization of latent brain hexokinase on synaptosomal mitochondria. PMID- 4337542 TI - The growth of foot-and-mouth disease virus in organ cultures of bovine tissues. PMID- 4337540 TI - Modification of 4-thiouridine and phenylalanine transfer RNA with parachlormercuribenzoate. PMID- 4337543 TI - The effect of certain amino acids on reproduction of encephalomyocarditis virus. I. Investigation of the inhibiting effect of L-lysine. PMID- 4337544 TI - RNA polymerase activity in virions of parainfluenza 1 virus (Sendai). PMID- 4337545 TI - Yellow fever vaccine. 3. Antibody response in monkeys inoculated with a vaccine free from contaminating avian leukosis viruses. PMID- 4337546 TI - Isolation of the SV40 induced tumor ("T") antigen from transformed hamster kidney cells. PMID- 4337547 TI - Studies with a rhinovirus of bovine origin. V. Serological relationships between the RS3x and other bovine rhinovirus strains. PMID- 4337548 TI - The protective effect of the interferon inducers tilorone hydrochloride and Poly I:C on experimental tick-borne encephalitis in mice. PMID- 4337549 TI - Alterations of L-cell cultures infected by influenza viruses. Brief report. PMID- 4337550 TI - Antigenic relationship between the virus of epizootic haemorrhagic disease of deer and bluetongue virus. Brief report. PMID- 4337551 TI - A comparative study of fibril formation from Coxsackie B 1 and other picornaviruses. Brief report. PMID- 4337552 TI - Isolation of glucanase-containing vesicles from budding yeast. PMID- 4337553 TI - [Decomposition of tartrate by lactobacilli]. PMID- 4337554 TI - Transfer ribonucleic acid synthetase catalyzed deacylation of aminoacyl transfer ribonucleic acid in the absence of adenosine monophosphate and pyrophosphate. PMID- 4337555 TI - Complex formation and energy transfer from photoexcited thiopyronine to deoxyribonucleic acid. PMID- 4337556 TI - A spin-label study of hemoglobin-haptoglobin complexes. PMID- 4337558 TI - Homonuclear indor spectroscopy as a means of simplifying and analyzing proton magnetic resonance spectra of peptides and as a basis for determining secondary and tertiary conformations of complex peptides. PMID- 4337557 TI - Studies on the enzymatic synthesis of the cyclic trimer of 2,3-dihydroxy-N benzoyl-L-serine in Escherichia coli. PMID- 4337559 TI - A simple biochemical method for the preparation of high specific activity ( 14 C) acyl-labelled phosphatidylcholine and other phospholipids. PMID- 4337560 TI - Uptake of rac-glycerol i-oleate and its utilization for glycerolipid synthesis by strain L fibroblasts. PMID- 4337561 TI - Lipids associated with cytochrome oxidase derived from yeast mitochondria. PMID- 4337562 TI - Structural studies on lipids of Tetrahymena pyriformis W. PMID- 4337564 TI - Studies on the composition and structure of plasma lipoproteins. Distribution of lipoprotein families in major density classes of normal human plasma lipoproteins. PMID- 4337565 TI - Formation of the -lactone of 3,5-dihydroxydecanoic acid by the fungus Cephalosporium recifei. PMID- 4337563 TI - A comparison of the intestinal absorption, lymph and plasma transport, and tissue uptake of -and -tocopherols in the rat. PMID- 4337566 TI - Evidence for biosynthetical equivalence of the epimeric isoleucine residues in angolide. PMID- 4337567 TI - Isolation and characterization of glycogen from Streptococcus salivarius. PMID- 4337568 TI - Pyridine-adenine dinucleotide transhydrogenase activity in cells cultured from rat hepatoma. PMID- 4337570 TI - Synthesis of uridine 5'-(L-arabinofuranosyl pyrophosphate) and the structure of the UDP-L-arabinose formed in plants from UDP- -D-xylopyranose. PMID- 4337571 TI - [Isolation and crystallisation of glycerol-3-phosphate dehydrogenase from rabbit liver]. PMID- 4337572 TI - [Semidehydro-D(-)-ascorbic acid as a substrate of microsomal NADH: semidehydroascorbate oxidoreductase (EC 1.6.5.4)]. PMID- 4337569 TI - Effect of estrogens on rat serum lipoproteins. PMID- 4337574 TI - The effect of adrenocorticotrophic hormone on glycerokinase activity in the rat adrenal gland. PMID- 4337573 TI - Developmental changes of glycolytic and gluconeogenic enzymes in fetal and neonatal rat liver. PMID- 4337575 TI - The in vitro 14 C-cyclic AMP production by normal human adipose tissue in response to some hormones and in uncontrolled and controlled diabetic adipose tissue. PMID- 4337576 TI - Complications associated with the administration of succinylcholine. PMID- 4337577 TI - Variations in tight and gap junctions in mammalian tissues. AB - The fine structure and distribution of tight (zonula occludens) and gap junctions in epithelia of the rat pancreas, liver, adrenal cortex, epididymis, and duodenum, and in smooth muscle were examined in paraformaldehyde-glutaraldehyde fixed, tracer-permeated (K-pyroantimonate and lanthanum), and freeze-fractured tissue preparations. While many pentalaminar and septilaminar foci seen in thin section and tracer preparations can be recognized as corresponding to well characterized freeze-fracture images of tight and gap junction membrane modifications, many others cannot be unequivocally categorized-nor can all freeze etched aggregates of membrane particles. Generally, epithelia of exocrine glands (pancreas and liver) have moderate-sized tight junctions and large gap junctions, with many of their gap junctions basal to the junctional complex. In contrast, the adrenal cortex, a ductless gland, may not have a tight junction but does possess large gap junctions. Mucosal epithelia (epididymis and intestine) have extensive tight junctions, but their gap junctions are not as well developed as those of glandular tissue. Smooth muscle contains numerous small gap junctions The incidence, size, and configuration of the junctions we observed correlate well with the known functions of the junctions and of the tissues where they are found. PMID- 4337579 TI - Reduction of malathion penetration in house flies pretreated with silicic acid. PMID- 4337578 TI - Epithelial-mesenchymal interactions during odontogenesis. 3. A simple method for the isolation of matrix vesicles. PMID- 4337580 TI - [Effect of nitrate reduction on carbon metabolism. 1. Changes in several enzyme activities in carbon metabolism in Escherichia coli by nitrate reduction]. PMID- 4337581 TI - [Plasma and urinary 17-KS and 17-OHCS in the field of pediatrics: interpretation of the test results]. PMID- 4337582 TI - [Characteristics of the morbidity among workers at Beocin cement factory based on cases selected at random]. PMID- 4337583 TI - Effect of hypothalamic preparations on human omental adipose tissue in vitro. PMID- 4337584 TI - Intestinal alkaline phosphatase: qualitative changes produced by deficient diet in rats. PMID- 4337585 TI - Responsiveness of bone to parathyroid extract in siblings with pseudohypoparathyroidism. PMID- 4337586 TI - "Big" insulin and the treatment of an islet cell carcinoma with streptozotocin. PMID- 4337588 TI - Mechanism of ACTH action. PMID- 4337587 TI - Effect of growth hormone on urinary 17-ketosteroids in childhood. PMID- 4337590 TI - [Trial of cytostatic therapy of malignant brain tumors in adults]. PMID- 4337589 TI - [Biological effect and importance of inorganic and organic silica compounds]. PMID- 4337591 TI - Heredofamilial aspects of narcolepsy and hypersomnia. PMID- 4337592 TI - Chronic alcoholic myopathy: an entity difficult to diagnose. PMID- 4337593 TI - Pericarditis due to Entamoeba histolytica. PMID- 4337595 TI - [Herpes simplex meningoencephalitis]. PMID- 4337594 TI - Effect of 15-azasteroid analogues on cell culture growth. PMID- 4337596 TI - [Diagnostic value of angiography in gastric cancer]. PMID- 4337597 TI - [Neutralizing antibodies to herpesvirus type 2 in the blood of women with genital cancer]. PMID- 4337598 TI - [Oncogenic activity of DNA preparations isolated from mouse tumors and organs]. PMID- 4337599 TI - [Combined and complex treatment of diffuse-infiltrative forms of breast cancer]. PMID- 4337600 TI - [Pathomorphological and histochemical changes caused by Cl. histolyticum collagenase in guinea pigs]. PMID- 4337601 TI - [Submicroscopic organization of Mycobacterium tuberculosis]. PMID- 4337602 TI - Effect of cooling on synaptic transmission through the cuneate nucleus. PMID- 4337603 TI - Effects of cooling on inhibitory processes in the cuneate nucleus. PMID- 4337604 TI - Convergence of large muscle spindle (Ia) afferents at interneuronal level in the reciprocal Ia inhibitory pathway to motoneurones. PMID- 4337605 TI - Prostaglandin induced inhibition of neurotransmission in the isolated guinea pig seminal vesicle. PMID- 4337606 TI - [Experimental studies on the development of the primary and secondary antibody forming potential in the early life. I. Development of the hemolysin-forming capacity after primary immunization of infantile NMRI mice]. PMID- 4337607 TI - Catalytic sites in rabbit muscle glyceraldehyde-3-phosphate dehydrogenase. Their number and their kinetic and spectral properties. PMID- 4337608 TI - Inactivation of lactate dehydrogenase by butanedione. PMID- 4337609 TI - Pyruvate-glyoxylate carboligase activity of the pyruvate dehydrogenase complex of Escherichia coli. PMID- 4337610 TI - Monoglucosyloxyoctadecenoic acid--a glycolipid from Aspergillus niger. PMID- 4337611 TI - Biosynthesis and chemistry of 9 ,15(S)-dihydroxy-11-oxo-13-trans-prostenoic acid. PMID- 4337612 TI - Arsenate and phosphate as modifiers of adenosine triphosphate driven energy linked reduction. Kinetic study of the effects of modifiers on inhibition by adenosine diphosphate. PMID- 4337613 TI - Mechanistic studies on horse liver alcohol dehydrogenase. The influence of the different premixings on the transient kinetics of aldehyde reductions. PMID- 4337614 TI - Purification and characterization of the deoxyribonucleic acid polymerase associated with Rous sarcoma virus. PMID- 4337615 TI - Ribonucleic acid directed deoxyribonucleic acid synthesis by the purified deoxyribonucleic acid polymerase of Rous sarcoma virus. Characterization of the enzymatic product. PMID- 4337617 TI - Uptake and metabolism of 3',5' -cyclic adenosine monophosphate and N 6 ,O 2' dibutyryl 3',5' -cyclic adenosine monophosphate in isolated bovine thyroid cells. PMID- 4337616 TI - Solvent and specificity. Binding and isoleucylation of phenylalanine transfer ribonucleic acid (Escherichia coli) by isoleucyl transfer ribonucleic acid synthetase from Escherichia coli. PMID- 4337618 TI - Effect of I,I,3 -tricyano- 2 -amino- I -propene on 2',3' -cyclic AMP 3' phosphohydrolase in the sciatic nerve of the chick embryo. PMID- 4337619 TI - Studies on the biosynthesis of NAD in Escherichia coli. 3. Precursors of quinolinic acid in vitro. PMID- 4337620 TI - Elevated glycosidases and proteolytic enzymes in cells transformed by RNA tumor virus. PMID- 4337621 TI - Time lag in the secretion of collagen by matrix-free tendon cells and inhibition of the secretory process by colchicine and vinblastine. PMID- 4337623 TI - Hemichromes in single inclusion bodies in red cells of beta thalassemia. PMID- 4337622 TI - Fatalities during remission of childhood leukemia. PMID- 4337624 TI - Intraerythrocytic crystalloid bodies in cats. PMID- 4337625 TI - Periodicity within sleep and operant performance in the cat. PMID- 4337626 TI - GABA-depolarization of a sensory ganglion: antagonism by picrotoxin and bicuculline. PMID- 4337627 TI - Electronic coupling between teleost oculomotor neurons; restriction to somatic regions and relation to function of somatic and dendritic sites of impulse initiation. PMID- 4337628 TI - Assay of neutralizing antibody against variola virus by the degree of focus reduction on HeLa cell cultures and its application to revaccination with smallpox vaccines of various potencies. AB - A method for assaying neutralizing antibody against variola virus was established by focus counting on HeLa cell cultures. The ND(50) titre, i.e., the serum dilution endpoint to give a 50% reduction in the number of foci, was determined with excellent reproducibility.Groups of students 19-20 years of age were revaccinated by the multiple pressure method with serial 10-fold dilutions of a smallpox vaccine and their neutralizing antibody response was assayed by the focus counting assay system and was related to the local skin reactions on the seventh day after inoculation and to the potency of the vaccine administered. There was a significant rise in the antibody level even after inoculation with a vaccine whose potency was as low as 1.3 x 10(5) pock-forming units/ml. In general, the rise in the log antibody level was proportional to the diameter of the reddening, but a significant rise was found among individuals who had no detectable skin reaction. The skin reaction was greater among individuals with a lower initial antibody level when the vaccine administered had a potency lower than 1.3 x 10(6) pock-forming units/ml. PMID- 4337630 TI - [Receptors and drugs. Enzyme activity and structure of effectors]. PMID- 4337629 TI - Study of the adrenocortical reserve function in paediatric cholera patients. AB - The adrenocortical reserve function of 20 cases of paediatric cholera was studied by intravenous ACTH tests. The findings indicate the presence of adrenocortical hyperactivity, and the poor response to ACTH stimulation shows that the adrenocortical reserve in these cases had been already stimulated to the maximum extent by salt depletion at the time of admission. These findings do not support the value of adrenocortical hormone treatment in cholera. PMID- 4337631 TI - [Physiology and pathophysiology of cortico-subcortical synchronization mechanisms]. PMID- 4337632 TI - Virus isolates from children with febrile convulsions in Nigeria. A correlation study of clinical and laboratory observations. PMID- 4337633 TI - Linitis plastica of the colon and rectum: report of two cases. PMID- 4337634 TI - [Variations of ocular tension during paradoxical sleep]. PMID- 4337635 TI - The morphology and pathogenesis of "Marburg virus" hepatitis. PMID- 4337636 TI - Necrotizing tracheobronchitis and bronchopneumonia consistent with herpetic infection. PMID- 4337637 TI - Relations among climbing fiber responses of nearby Purkinje Cells. PMID- 4337638 TI - Collagen synthesis in human skin fibroblasts: effects of ascorbate, ketoglutarate and ferrous ion on proline hydroxylation. PMID- 4337639 TI - Incorporation and distribution of dietary elaidate in the major lipid classes of rat heart and plasma lipoproteins. PMID- 4337640 TI - The effect of anesthetic method upon the results of bronchial washing cytology. An analysis of 1,886 cases. PMID- 4337641 TI - [Experience with the diagnostic and therapeutic use of herpetic polyvaccine]. PMID- 4337642 TI - Some pathological aspects of the spontaneous lymphoid tumour in Xenopus laevis. PMID- 4337643 TI - [Ultrastructure of phagocytizing granulocytes in childhood chronic granulomatous disease]. PMID- 4337645 TI - ESR studies of the low temperature irradiation of keratin and its component amino acids. PMID- 4337644 TI - Time relationships between injection of antigen and adjuvant. II. Immunosuppression induced by Bordetella pertussis vaccine when given before secondary antigenic stimulation. PMID- 4337646 TI - Human enteroviruses in animals and arthropods in the central Philippines. PMID- 4337647 TI - 3 -Hydroxy- 5 -C 19 -and C 21 -steroid oxidoreductase activity in rat liver. PMID- 4337648 TI - Determination of estrogens by radioimmunoassay with antibodies to estrogen-C6 conjugates. I. Synthesis of estrone-, estradiol-17 -, and estriol-6-albumin conjugates. PMID- 4337650 TI - The metabolism of estrone-6,7- 3 H by sheep fetal liver in vitro. PMID- 4337649 TI - Pattern of estetrol conjugation in the human. PMID- 4337651 TI - [Therapy with cortisone, cortisonoids and ACTH]. PMID- 4337652 TI - [Neuromuscular disorders, especially myasthenia]. PMID- 4337653 TI - [Pathogenesis of Balkan endemic nephropathy]. PMID- 4337654 TI - [Pseudotabes diabetica in the light of a personal case]. PMID- 4337655 TI - Hepatic lipogenesis in two cases with insulin-producing tumor of the pancreas. PMID- 4337657 TI - Depression of the click action potential by attenuation, cooling, and masking. PMID- 4337656 TI - Antagonism between glucose and epinephrine regarding insulin secretion. A dose response study in man. PMID- 4337658 TI - [Effect of ACTH on carotene utilization at varying dietary protein levels]. PMID- 4337659 TI - [Spinal reflex during natural sleep in the kitten]. PMID- 4337660 TI - [Effects of angiotensin administration on renin secretion]. PMID- 4337661 TI - [Reports and prospects: neuromuscular diseases and manic-depressive psychoses]. PMID- 4337662 TI - Enzyme studies in perinatal tissues of normal, hypothermic, hypotrophic, and hypoxic rabbits. PMID- 4337663 TI - A hybrid computer system for unsupervised scoring of sleep records. PMID- 4337664 TI - Arteriography in Wilms' tumour--the results of 13 cases and comparison to renal dysplasia. PMID- 4337666 TI - [The importance of lymphography for diagnostics of some oncological diseases]. PMID- 4337667 TI - [Contribution to the problems of physiological application of oil contrast substances in lymphography]. PMID- 4337665 TI - Prediction of adrenal hypofunction in anaesthesia. PMID- 4337669 TI - Incorporation of Se75 selenomethionine into a protein component of plasma very low-density lipoprotein in man. PMID- 4337668 TI - Biosynthesis and reactivity of the glucuronide of N-hydroxy-4 acetylaminobiphenyl. PMID- 4337670 TI - [Presidential address. Health is harmony]. PMID- 4337671 TI - Formation of antibody in rabbit spleen cell cultures stimulated with immunogenic RNA. PMID- 4337672 TI - The influence of calcium, magnesium and cyclic adenosine 3',5'-monophosphate on the mixed lymphocyte reaction. PMID- 4337673 TI - Effects of pyran copolymer on oncogenic virus infections in immunosuppressed hosts. PMID- 4337675 TI - [Medical therapy of rheumatic disease in the acute phase]. PMID- 4337674 TI - [Bacteriological studies of carbenicillin]. PMID- 4337676 TI - [Cylindromas localized in the salivary glands]. PMID- 4337677 TI - Hepatocellular carcinoma, diagnosed following metastasis to the mandible. Report of a case. PMID- 4337678 TI - [Effect of metopyrone on the levels of ACTH and 11-HCS in the plasma and the excretion of individual 17-HCS and 17-KS in Itsenko-Cushing disease]. PMID- 4337679 TI - Radiology of the orbit in infancy and childhood. PMID- 4337681 TI - On chemistry and biology of mycobacterial lipid fractions. PMID- 4337680 TI - Neural ventilatory drive during arm and leg exercise. PMID- 4337682 TI - [Excretion of Clostridium perfringens by black flies]. PMID- 4337683 TI - Organization and ultrastructural identification of the catecholamine nerve terminals in the neural lobe and pars intermedia of the rat pituitary. PMID- 4337684 TI - [Fine structure of the so called micro calcification in breast tumors]. PMID- 4337685 TI - [Electron microscopic studies on experimental brain tumors in rats]. PMID- 4337686 TI - [Tumors of the nervous system in rats following intraperitoneal injections of methylnitrosourea]. PMID- 4337687 TI - [Activities of glutamate dehydrogenase and aspartate aminotransferase in human brain tumors]. PMID- 4337689 TI - [Differential diagnosis of chemolectoma and alveolar soft tissue sarcoma]. PMID- 4337688 TI - [Incidence of hypophyseal metastases. Pathological and anatomical study]. PMID- 4337690 TI - [Post- and prenatal induction of nervous system tumors in rats by phenyl-dimethyl triazene]. PMID- 4337691 TI - [Differential diagnosis of glomus tumors]. PMID- 4337692 TI - [Comparative microbiological studies of contaminated soils. II. Qualitative changes of microbial species]. PMID- 4337693 TI - Bilateral adenoma of nipple. Report of a case. PMID- 4337694 TI - Supraspinal control of monosynaptically activated group Ia interneurones in the ventral horn. PMID- 4337695 TI - Convergence in the reciprocal Ia inhibitory pathway of excitation from descending pathways and inhibition from motor axon collaterals. PMID- 4337696 TI - Perspective. Chlorpropamide hyponatremia. PMID- 4337697 TI - Effect of angiotensin II on urinary magnesium, calcium, and sodium excretion in normal subjects. PMID- 4337698 TI - [Value of cytophotometry in the detection of precancerous lesions]. PMID- 4337699 TI - Experimental studies by tissue culture of a new murine leukosis virus (ML. V). PMID- 4337700 TI - Effects of renal transplantation on motor nerve conduction velocity. PMID- 4337701 TI - Structure and function of gas vacuoles. PMID- 4337703 TI - Increased hepatic phosphoprotein phosphatase activity induced by phenobarbital and its supression by cycloheximide and SKF 525-A. PMID- 4337702 TI - Assay of glycogen phosphorylase in isolated fat cells of the rat. PMID- 4337704 TI - Increased heart adenylcyclase activity in the hypothyroid rat. PMID- 4337705 TI - Manganous ion as a spin label in studies of mitochondrial uptake of manganese. AB - Manganous ion (Mn(2+)) has been used as a spin label for studies of divalent cation uptake by rat liver mitochondria. Spin exchange, observed in the electron paramagnetic resonance (EPR) spectrum of a fraction of the transported Mn(2+), shows that this fraction is bound in regions of high local concentration within the mitochondria. The average separation of manganese ions in that fraction is estimated to be 4.0 +/-0.6 A at the time of greatest concentration. PMID- 4337706 TI - [Effect of thyroidectomy on the functional state of the hypothalamo-hypophyseco adrenal system]. PMID- 4337707 TI - The cellular localization of lactate dehydrogenase in skeletal muscle of eel (Anguilla anguilla). PMID- 4337708 TI - [Existence of an intracellular pool of soluble amylase in the pigeon pancreas]. PMID- 4337709 TI - Lysosomal enzymes in aquatic species. II. Distribution and particle properties of thermally acclimated muscle lysosomes of rainbow trout, Salmo gairdneri. PMID- 4337710 TI - Lysosomal enzymes in aquatic species. 3. Zonal centrifugation studies of thermally acclimated skeletal muscle lysosomes of rainbow trout, Salmo gairdneri. PMID- 4337711 TI - Biogenesis of mitochondria during Xenopus laevis development. PMID- 4337712 TI - Control of development: the cellular slime molds. PMID- 4337713 TI - [Malignant tumors of the mesopharynx]. PMID- 4337715 TI - Rous sarcomas in mice: the chromosomal progression during early in vivo transplantation. PMID- 4337714 TI - [Cytology of the anterior pituitary in adrenocortical hypoplasia with hypoglycaemia]. PMID- 4337716 TI - [Colloquium: episome and plasmid]. PMID- 4337717 TI - [Computer scintigraphy in diagnosis of tumors]. PMID- 4337718 TI - [Clinical observation of neck swelling--metastatic cancer of the neck without detectable primary site]. PMID- 4337719 TI - [Effects of selective administration of anticancer agents in massive dosage combined with fibrolytic enzyme (urokinase) in hepatic cancer]. PMID- 4337721 TI - [Phyllodes type tumor of the breast]. PMID- 4337720 TI - [Metastasis to the axillary lymph nodes as the first clinical sign of cancer of the breast]. PMID- 4337722 TI - [Clinico-cytological parallels in the diagnosis of malignant melanomas of the skin]. PMID- 4337723 TI - [Evaluation of methods of treating patients with malignant tumors of soft tissue]. PMID- 4337724 TI - Digestion and the distribution of acid phosphatase in the myxamoebae of Physarum flavicomum. PMID- 4337725 TI - Apical vesicles in germinating conidia of Aspergillus parasiticus. PMID- 4337726 TI - Assay of phosphodiesterase with radioactively labeled cyclic 3',5'-AMP as substrate. PMID- 4337727 TI - [Fibrocystic pancreatitis and cytomegaly]. PMID- 4337728 TI - [Wiskett-Aldrich syndrome (report of a case)]. PMID- 4337729 TI - Septal unit activity and hippocampal EEG during the sleep-wakefulness cycle of the rat. PMID- 4337730 TI - [Features of specific immunological reactions in acute respiratory diseases in children during their first year of life]. PMID- 4337731 TI - [Adrenocorticotropic function of the hypophisis in postabortive sepsis]. PMID- 4337732 TI - [Age-associated changes in the peripheral nerve trunks]. PMID- 4337733 TI - [Effect of large doses of drug compounds on changes in the blood indices of patients with malignant neoplasms of the extremities]. PMID- 4337734 TI - Ultrastructure of the developing thymus of the leopard frog (Rana pipiens). PMID- 4337735 TI - [The fine structure of the complex eye of the ant Formica polyctena (Hymenoptera, Formicidae)]. PMID- 4337736 TI - [Size of fat particles in muscle fibres rich in mitochondria (rat) and its relation to nourishment]. PMID- 4337737 TI - Selective angiography in surgical management of pancreatic insulomas. PMID- 4337739 TI - Specific associations between complement-fixing antibodies to herpesviruses and those to some serotypes of adenovirus-associated viruses. PMID- 4337738 TI - Carcinoma of the colon. A review of 554 patients. PMID- 4337741 TI - Inhibition of DNA synthesis in hamster cheek pouch tissue in organ culture by dibutyryl cyclic AMP and a homologous extract. PMID- 4337740 TI - Functioning beta cell tumors (insulinomas) of the pancreas. PMID- 4337742 TI - The role of the mitochondria in rat liver mixed function oxidation reactions. PMID- 4337743 TI - A non-functional arginine biosynthetic pathway in polyoma infected-mouse embryo cells. PMID- 4337744 TI - Mitochondrial proliferation during neonatal renal compensatory growth. PMID- 4337745 TI - Application of laser beat frequency spectroscopy to the detection and characterization of an oncogenic RNA virus. PMID- 4337747 TI - Function of energy-dependent transhydrogenase in Escherichia coli. PMID- 4337746 TI - Gladiolic acid and related aromatic ortho-dialdehydes, a novel class of mitochondrial inhibitors. Inactivation of cytochrome c. PMID- 4337748 TI - The inhibition of cytochrome oxidase by lysosomal cationic proteins of rabbit polymorphonuclear leukocytes. PMID- 4337749 TI - Antamanide and analogs. Studies on selectivity and stability of complexes. PMID- 4337750 TI - Effects of nicotinic acid on human fibroblast purine biosynthesis. PMID- 4337751 TI - Elution of human satellite DNAs on a methylated albumin kieselguhr chromatographic column: isolation of satellite DNA. IV. PMID- 4337752 TI - Heterologous charging of Neurospora crassa phenylalanine tRNA by Escherichia coli valyl-tRNA synthetase. PMID- 4337754 TI - Motor and sensory conduction in infancy and childhood: reappraisal. PMID- 4337753 TI - Low molecular weight chromatin-associated RNA from rat liver. PMID- 4337755 TI - Enzymes in rat urine: alkaline phosphatase. PMID- 4337756 TI - Action of ethionine, methionine, ATP, adenine, albumin and Ca 2+ on protein synthesis of normal and tumor cells. PMID- 4337757 TI - The aortic tunica intima in young and aging rats. PMID- 4337758 TI - Pathogenicity of Bacillus cereus for insects. I. Production of phospholipase C. PMID- 4337759 TI - Pathogenicity of Bacillus cereus for insects. II. Toxicity of phospholipase C for Galleria mellonella. PMID- 4337760 TI - [Malignant tumors of the nasal septum]. PMID- 4337761 TI - Carcinoma of the breast and Klinefelter's syndrome. PMID- 4337762 TI - Nature of synaptic events in cat abducens motoneurons at slow and quick phase of vestibular nystagmus. PMID- 4337763 TI - Steps in production of motoneuron spikes during rhythmic firing. PMID- 4337764 TI - Membrane-potential trajectories between spikes underlying motoneuron firing rates. PMID- 4337765 TI - Transformations of discharges of neurons of parietal association cortex during sleep and wakefulness in monkey. PMID- 4337766 TI - Central nervous control of presynaptic inhibition in the crayfish claw. PMID- 4337767 TI - Repetitive firing behavior of mammalian muscle spindle. PMID- 4337768 TI - Presynaptic and postsynaptic inhibition of spinal motoneurons. PMID- 4337769 TI - Urinary excretion of adenosine 3',5'-monophosphate and guanosine 3',5' monophosphate. PMID- 4337771 TI - An ESR study of pyrimidine, pyrimidine nucleoside and halopyrimidine anions. PMID- 4337770 TI - Concerning the production of free radicals in proteins by ultraviolet light. PMID- 4337772 TI - Effects of hypophysectomy and ACTH 1-10 on responsiveness to electric shock in rats. PMID- 4337773 TI - An improved push-pull cannula system for perfusing an isolated region of the brain. PMID- 4337774 TI - Radiation protection of heparin in the solid state. PMID- 4337775 TI - [Cyclophosphamide in the therapy of multiple sclerosis]. PMID- 4337776 TI - [Pickwickian-narcoleptic disorders after brain concussion]. PMID- 4337777 TI - [Electrolyte changes and mental disorders]. PMID- 4337778 TI - Gas chromatographic quantitation of steroids in health and disease. 4. Determination of conjugated cortisol metabolites in urine. PMID- 4337779 TI - Pemoline: review of performance. PMID- 4337780 TI - [Therapy of bladder tumors. After care and control]. PMID- 4337781 TI - [Effect of ACTH on ascorbic acid concentration in adrenal glands and liver during piglet development]. PMID- 4337782 TI - [Role of the autonomic nervous system in the pathogenesis of allergy, with special reference to organ vagotony]. PMID- 4337784 TI - Effects of theophylline on myocardial mechanics. PMID- 4337783 TI - Secondary malignant tumors of the parathyroid glands. Report of two cases with associated hypoparathyroidism. PMID- 4337785 TI - Effect of hyperbaric oxygen and norepinephrine on the level of lung ascorbic acid. PMID- 4337786 TI - Effects of chronic ACTH stimulation on adrenocortical function in young and aged rats. PMID- 4337787 TI - Increased oxidative metabolism in the fetal and newborn lamb heart. PMID- 4337788 TI - Adrenal response to experimental arthritis in the rat. PMID- 4337789 TI - Cobalt chloride-induced hyperlipemia in the rat: effects on intermediary metabolism. PMID- 4337790 TI - Postocclusive vascular responses in isolated perfused kidney of rabbits. PMID- 4337791 TI - Strength of the nervous system as a function of personality type and level of arousal. PMID- 4337792 TI - The organization of cholinesterase-containing systems of the monkey spinal cord. PMID- 4337793 TI - Effects of experimentally induced diapause on the electrophysiology and protein synthesis patterns of identified molluscan neurons. PMID- 4337794 TI - The subcellular distribution of acetylcholine, cholinesterases and choline acetyltransferase in optic lobes of the squid Loligo pealei. PMID- 4337795 TI - Two components of the antidromic IPSPs in the pyramidal tract cells. PMID- 4337796 TI - Evaluation of the number and distribution of synaptic vesicles at cholinergic nerve-endings after sustained stimulation. PMID- 4337797 TI - Further information on the survival of modified foot-and-mouth disease virus in cattle. PMID- 4337799 TI - Further studies on markers of foot-and-mouth disease virus. PMID- 4337798 TI - Experimental inoculation of sheep with foot-and-mouth disease virus. PMID- 4337800 TI - [Results of vasopressin and post-insulin hypoglycemia tests based on the determination of plasma 11-hydroxycorticosteroids level in healthy persons]. PMID- 4337801 TI - [Radiological findings in primary vascular hypertension]. PMID- 4337802 TI - [Coronary circulation after vascular occlusion. 3. Contraction insufficiency of ventricular myocardium after acute coronary occlusion]. PMID- 4337803 TI - Selective coronary arteriography and aortocoronary venous bypass grafts. PMID- 4337804 TI - [Tumor-simulating stomach diseases and their differential diagnosis. II. Differential diagnosis of pyloric stenosis]. PMID- 4337805 TI - [Indirect (arterial) spleno-portography in the diagnosis of portal hypertension]. PMID- 4337806 TI - [Angio-scintigraphy of the kidneys]. PMID- 4337808 TI - [Data processing in the radio-iodine test]. PMID- 4337807 TI - [Comparative examinations of liver blood flow using 198 Au micro-particles and 99m Tc-S colloid]. PMID- 4337809 TI - [A dosimeter for radioactive isotopes]. PMID- 4337810 TI - [Evaluation of production rates for medico-technical assistants in nuclear medicine facilities]. PMID- 4337811 TI - [Diagnosis of carcinoma of the breast by infra-red thermography]. PMID- 4337812 TI - [Post-operative lympho-scintigraphy for carcinoma of the breast]. PMID- 4337813 TI - [Results of preventive irradiation of the lymphatic drainage in the neck]. PMID- 4337815 TI - [The occurrence of pseudo-sharpness in the centre of x-ray beams]. PMID- 4337814 TI - [Tomographic diagnosis of the petrus bone with spiral blurring]. PMID- 4337816 TI - [Radiation dose to the ovaries during hysterosalpingopelvigraphy]. PMID- 4337817 TI - ["Anemic" pulmonary infarction]. PMID- 4337818 TI - [Thoracic wall edema in subclavian thrombosis simulating a diffusely growing carcinoma of the breast with peau d'orange]. PMID- 4337819 TI - [The angiographic picture of pheochromocytoma in the organs of Zuckerkandl]. PMID- 4337820 TI - [Angiographic demonstration of an adrenal gland cyst]. PMID- 4337821 TI - [A case of choledochal diverticulum with secondary calculus formation]. PMID- 4337822 TI - [Cinematographic demonstration of a bilio-pancreatic collateral circulation of the major duodenal papilla]. PMID- 4337823 TI - [Clinical significance of skin tests in respiratory hypersensitivity]. PMID- 4337824 TI - [Rhinitis and it's therapy with Co-Tylenol]. PMID- 4337826 TI - [Isolation of Enterovirus from cattle with respiratory and enteric diseases]. PMID- 4337825 TI - [Detection of antibodies against infectious bovine viral rhinotracheitis (IBR) and infectious pustular vulvovaginitis (IPV) in cattle]. PMID- 4337827 TI - [Androgenic tumor in a 23-year-old woman. Clinical, biological and radiological study]. PMID- 4337828 TI - Studies of mammary carcinoma induced by 7,12-dimethylbenz(a)anthracene administration. PMID- 4337830 TI - Studies on the mechanism of glycogen storage in ascites hepatomas. PMID- 4337829 TI - Stress and murine sarcoma virus (Moloney)-induced tumors. PMID- 4337831 TI - Electrophoretic analysis of the RNA from a mouse leukemia virus. PMID- 4337832 TI - Increased susceptibility of cells from cancer patients with XY-gonadal dysgenesis to simian papovavirus 40 transformation. PMID- 4337833 TI - Ether-lipids, -glycerol phosphate dehydrogenase, and growth rate in tumors and cultured cells. PMID- 4337834 TI - On the correlation between the hepatocarcinogenicity of the carcinogen, N-2 fluorenylacetamide, and its metabolic activation by the rat. PMID- 4337835 TI - Type C viruses in the pancreas of normal C57BL mice. PMID- 4337836 TI - [Morphology and classification of symbrachydactylia]. PMID- 4337837 TI - Electron-microscopic observations on Sendai virus-induced chromosome pulverization in HeLa cells. PMID- 4337838 TI - Chromosomal analysis of primary and metastatic Rous sarcomas in the rat. PMID- 4337839 TI - Meiotic aneuploidy in a mouse strain with latent ectromelia infection. PMID- 4337840 TI - Immunology of foot-and-mouth disease in swine: experimental inactivated-virus vaccines. PMID- 4337841 TI - Comments on immunology of foot-and-mouth disease in swine. PMID- 4337842 TI - Pathogenesis and immunity of Clostridium perfringens type C enteritis in swine. PMID- 4337843 TI - Comments on clostridia and enteric diseases in swine. PMID- 4337844 TI - Immune response to porcine enteroviruses: effect of antigenic variations on classification. PMID- 4337846 TI - Comments on WHO swine viral reagents. PMID- 4337845 TI - The need and requirements for WHO swine viral reagents. PMID- 4337847 TI - Summary of the colloquium on immunity to selected diseases of swine. PMID- 4337848 TI - Yeast membrane vesicles: isolation and general characteristics. AB - Yeast membrane vesicles are formed when packed yeast are ground manually in a porcelain mortar and pestle with glass beads (0.2 mm diameter). These vesicles can be separated from the other components of the grinding mixture by a combination of centrifugation steps and elution from a column of the same glass beads (0.2 mm diameter). Isolated vesicles are osmotically sensitive, contain cytoplasmic components, and have energy-independent transport function. They are unable to metabolize glucose, but have respiratory function which is thought to be associated with intravesicular mitochondria. Invertase and oligomycin insensitive adenosine triphosphatase are present in lysed vesicle preparations, and the appropriateness of these enzyme activities as membrane markers is discussed. PMID- 4337849 TI - Serine biosynthesis and its regulation in Bacillus subtilis. AB - Cell-free extracts of Bacillus subtilis strains GSY and 168 convert (14)C phosphoglycerate to (14)C-serine phosphate and (14)C-serine. These reactions indicate a functional phosphorylated pathway for serine biosynthesis in these cells. The addition of serine to the incubation mixture inhibited the formation of both radioactive products. Extracts of mutant strains that require serine for growth lacked the capacity to synthesize serine phosphate, confirming that the phosphorylated pathway was the only functional pathway available for serine synthesis. Serine phosphate phosphatase and phosphoglycerate dehydrogenase activity were demonstrated in cell extracts, and the phosphoglycerate dehydrogenase was shown to be inhibited specifically by l-serine. The extent of serine inhibition increased when the temperature was raised from 25 to 37 C, and the thermal stability of the enzyme was enhanced by the presence of the inhibitor serine or the coenzyme reduced nicotinamide adenine dinucleotide. At 37 C the curve representing the relationship between phosphoglycerate concentration and enzyme velocity was biphasic, and the serine inhibition which was competitive at low substrate concentrations became noncompetitive at higher concentrations. PMID- 4337850 TI - Development of a membrane-bound resiratory system prior to and during sporulation in Bacillus cereus and its relationship to membrane structure. AB - Bulk membrane fragments were prepared from cells of Bacillus cereus ATCC 4342 harvested at different stages of growth and sporulation and examined for enzymes involved in electron transport functions. The presence of succinate: DCPIP oxidoreductase (EC 1.3.99.1), succinate: cytochrome c oxidoreductase (EC 1.3.2.1), NADH:DCPIP oxidoreductase (EC 1.6.99.1), NADH:cytochrome c oxidoreductase (EC 1.6.2.1), succinate oxidase [succinate: (O(2)) oxidoreductase, EC 1.3.3.1], and NADH oxidase [NADH:(O(2)) oxidoreductase, EC 1.6.3.1] were demonstrated in membrane fragments from vegetative cells, early and late stationary-phase cells, and in cells undergoing sporulation. During the transition from a vegetative cell to a spore, there was a significant increase in the levels of enzymes associated with energy production via the electron transport system. Cytochromes of the a, b, and c type were detected in all membrane preparations; however, there was a marked increase in the level of cytochromes by the end of vegetative growth which remained throughout sporulation; there were no qualitative changes in the cytochromes throughout growth and sporulation. Sporulation was inhibited by cyanide, stressing the significance of the electron transport system. Enzyme activities were partially masked in washed membrane fragments; however, unmasking (stimulation) was achieved by sodium deoxycholate, sodium dodecyl sulfate, or Triton X-100. The degree of enzyme masking was less in vegetative cell membrane fragments than in membranes prepared from stationary-phase or sporulating cells. Results indicate the development of a membrane-bound electron transport system in B. cereus by the end of growth and prior to sporulation, which results in an increased masking of a number of enzymes associated with the terminal respiratory system of the cell. PMID- 4337851 TI - The size and number of polypeptide chains in human serum low density lipoprotein. PMID- 4337852 TI - Enzymatic phosphorylation of serine. PMID- 4337853 TI - The purification and properties of superoxide dismutase from Neurospora crassa. PMID- 4337855 TI - The mechanism of aconitase action. 3. Detection and properties of enzyme-metal substrate and enzyme-metal-inhibitor bridge complexes with manganese(II) and iron(II). PMID- 4337854 TI - Affinity labeling of steroid binding sites. Synthesis of 16 bromoacetoxyprogesterone and its use for affinity labeling of 20 -hydroxysteroid dehydrogenase. PMID- 4337856 TI - Artificial substrates in squalene and sterol biosynthesis. PMID- 4337857 TI - Electron spin resonance of the iron-containing protein B2 from ribonucleotide reductase. PMID- 4337858 TI - The biosynthesis of basement membrane collagen in embryonic chick lens. I. Delay between the synthesis of polypeptide chains and the secretion of collagen by matrix-free cells. PMID- 4337859 TI - Interaction of glucocorticoids with glucagon and epinephrine in the control of gluconeogenesis and glycogenolysis in liver and of lipolysis in adipose tissue. PMID- 4337860 TI - Enzymatic reduction of spin-labeled ferrihemoglobin. PMID- 4337862 TI - The effects of dorsal root lesions on Clarke neurons in cats of different ages. PMID- 4337861 TI - Ultrastructure of developing Xenopus retina before and after ganglion cell specification. PMID- 4337863 TI - Attempted transmission of warts from man, cattle, and horses and of deer fibroma, to selected hosts. PMID- 4337864 TI - Changes in kidney cortex gluconeogenic enzymes induced by 1,1,1-trichloro-2,2-bis (p-chlorophenyl)ethane (DDT). PMID- 4337865 TI - Effect of reserpine, phenoxybenzamine and cocaine on neuromuscular transmission in the vas deferens of the guinea pig. PMID- 4337866 TI - Interactions of bretylium and drugs that inhibit the neuronal membrane transport of norepinephrine in isolated rabbit atria and aortae. PMID- 4337868 TI - Electron microscopic studies on substrate specificity of T4 excision repair endonuclease. PMID- 4337867 TI - [Evaluation of 2 phases of corticotropin activity, "impulsive" and "basal," in obesity of the flaccid type]. PMID- 4337869 TI - [Biochemical and clinical aspects of collagen metabolism]. PMID- 4337870 TI - [Effect of anticholinesterase compounds on neuromuscular transmission]. PMID- 4337871 TI - Correlations between protein and serotonin synthesis during various activities of the central nervous system (slow and desynchronized sleep, learning and memory, sexual activity, morphine tolerance, aggressiveness, and pharmacological action of sodium gamma-hydroxybutyrate). PMID- 4337872 TI - Skeletal metastasis in primary carcinoma of the liver. PMID- 4337875 TI - [The so-called granular cell myoblastoma: Differential diagnosis in breast carcinomas]. PMID- 4337873 TI - [Cytomorphologic and morphometric investigations of hepatocarcinogenesis. I. Reversible and irreversible cytoplasmic alterations of hepatocytes in nitrosomorpholine-intoxicated rats]. PMID- 4337874 TI - [Cytomorphologic and morphometric studies on hepatocarcinogenesis. II. Reversibility of cell-nucleus changes in nitrosomorpholine poisoned rat liver]. PMID- 4337877 TI - [Hetacillin: microbiological activity in vitro]. PMID- 4337876 TI - Analysis of 115 patients with tumors of the submandibular gland. PMID- 4337878 TI - [Improvement of technological processes in the production of 6-aminopenicillanic acid (6-APA)]. PMID- 4337879 TI - [Experimental studies on lincomycin in anaerobic (gaseous) infection]. PMID- 4337881 TI - [Effect of generalized staphylococcal infection on permeability of placenta barrier and distribution of ristomycin sulphate in blood and organs of albino rats]. PMID- 4337882 TI - Tumor-inhibitory effect of a streptococcal preparation (NSC-B116209). PMID- 4337880 TI - [Comparative analysis of the effect of polymyxin and monomycin on dysentery bacteria and enteropathogenic Coli bacteria in experiments and clinical cases]. PMID- 4337883 TI - RNA tumor virus gs antigen and tumor induction by various doses of 3 methylcholanthrene in various strains of mice treated as weanlings. PMID- 4337884 TI - Intratumor therapy in rodents with aqueous clam extracts. PMID- 4337885 TI - Differential effects of infection with herpes simplex virus on the chromosomes of human hematopoietic cell lines. PMID- 4337886 TI - Comparison of the specificity and extent of in vitro methylation by guanylate residue-specific transfer RNA methylases isolated from ascites hepatoma, 3' methyl-4-dimethylaminoazobenzene-induced hepatoma, and normal rat liver. PMID- 4337887 TI - Isozyme patterns of branched-chain amino acid transaminase in various rat hepatomas. PMID- 4337888 TI - Phytosterols in normal and tumor-bearing rats. PMID- 4337889 TI - Aldolase C in cultured mouse glioblastoma cells. PMID- 4337890 TI - Morphological studies on Herpesvirus sylvilagus in rabbit kidney cell cultures. PMID- 4337891 TI - [Gonadotropin]. PMID- 4337892 TI - [Thyroid gland hormones]. PMID- 4337893 TI - [Parathyroid hormone]. PMID- 4337894 TI - Three-dimensional computerized display of physiologic models and data. PMID- 4337895 TI - Electrophysiology of pelvic and pudendal nerves in the cat. PMID- 4337897 TI - [A study on kinetics of thin-layer chromatography of amino acids on silica gel]. PMID- 4337896 TI - Regulation of the corpus luteum during the menstrual cycle and early pregnancy. PMID- 4337898 TI - Identification of dansyl amino acids using a single solvent and a layer composed of three sorbents. PMID- 4337899 TI - [Application of ethyl silicate amine method to dental investments for higher temperature casting]. PMID- 4337900 TI - [Binderless silica investments for dental casting]. PMID- 4337901 TI - Solid-phase synthesis of (6-arginine)-, (4-histidine, 6-tyrosine)-, and (8 isoleucine)angiotensins II. PMID- 4337902 TI - Bisbenzimidazoles. Potent inhibitors of rhinoviruses. PMID- 4337903 TI - Fluorinated pyrimidines. 41. Syntheses of 5-trifluoromethyl-3'-deoxyuridine and 5 fluoro-3'-deoxyuridine. PMID- 4337904 TI - Increase of Epstein-Barr-virus-positive cells in EB3 cultures after treatment with cis-dichloro-diammine-platinum. PMID- 4337906 TI - Morphologic studies of a cytomegalovirus isolated from an owl monkey. PMID- 4337905 TI - Hyperplastic and early neoplastic changes in the ovaries of mice after genic deletion of germ cells. PMID- 4337907 TI - Effects of dimethylsulfoxide on expression of differentiated functions in mouse neuroblastoma. PMID- 4337908 TI - Serial transplantation of urethan-treated mammary nodule outgrowth line D1. PMID- 4337909 TI - Role of 3',5'-adenosine monophosphate in regulation of morphology and growth of transformed and normal fibroblasts. PMID- 4337911 TI - Effect of normal serum and antithymocyte serum on Friend disease in mice. PMID- 4337910 TI - -Glutamyl transpeptidase in transplantable, chemically induced rat hepatomas and "spontaneous" mouse hepatomas. PMID- 4337912 TI - Histopathology of tumor regression after intralesional injection of Mycobacterium bovis. I. Tumor growth and metastasis. PMID- 4337913 TI - Isolation of Herpesvirus saimiri from blood of squirrel monkeys (Saimiri sciureus). PMID- 4337914 TI - Marek's disease herpesvirus particles in tissues from chickens free of precipitating antibodies. PMID- 4337915 TI - Hepatomas induced by aflatoxin in the sockeye salmon (Oncorhynchus nerka). PMID- 4337916 TI - Proteolytic activity and basic protein loss in and around multiple sclerosis plaques: combined biochemical and histochemical observations. PMID- 4337917 TI - Isolation and some chemical properties of oligodendroglia from calf brain. PMID- 4337918 TI - Separation of catecholamine storing synaptosomes in colloidal silica density gradients. PMID- 4337919 TI - [Metabolic heterogeneity of rat brain sphingomyelins]. PMID- 4337920 TI - The presence of 2',3'-cyclic AMP 3'-phosphohydrolase in glial cells in tissue culture. PMID- 4337921 TI - [Importance of genetic structure in the spread and ecology of enteroviruses]. PMID- 4337922 TI - Prebiotic phosphorylation of thymidine at 65 degrees C in simulated desert conditions. PMID- 4337923 TI - Paleocortical excitability and sensory filtering during REM sleep deprivation. PMID- 4337924 TI - Individual differences in hippocampal EEG during rhombencephalic sleep and arousal. PMID- 4337925 TI - Intracranial reward and the forebrain's serotonergic mechanism: studies employing para-chlorophenylalanine and para-chloroamphetamine. PMID- 4337926 TI - [Polygraphic and behavioral study of the states of vigilance in the premature guinea pig]. PMID- 4337928 TI - Concentration of virus from water by electro-osmosis and forced-flow electrophoresis. II. Improvement of methodology and application to tap water. PMID- 4337927 TI - Salivary secretion of electrolytes. PMID- 4337929 TI - Electron microscopic examination and quantitation of rhapidosomes, viruses and bacteria concentrated at an aqueous-air interface. PMID- 4337931 TI - La Malinconia: final movement of Beethoven's Quartet Op. 18, No. 6--a musical account of manic depressive states. PMID- 4337930 TI - [Regulation of anaerobic glycolysis in liver slices of diabetic rats]. PMID- 4337932 TI - Fluorescence and electron microscopic observations of the general visceral, efferent innervation of the inner ear. PMID- 4337933 TI - Improved quantitative assay procedures for lipopolysaccharide and peptidoglycan components of Escherichia coli. PMID- 4337934 TI - Rapid assay for purine phosphoribosyltransferases. PMID- 4337935 TI - Radiochemical assay for UDP-glucose dehydrogenase. PMID- 4337937 TI - [Hetacillin: protective action and serum and tissue levels]. PMID- 4337936 TI - Simple chromatographic method for determination of 14 C-labeled lysine, hydroxylysine, and hydroxylysine glycosides. PMID- 4337939 TI - Phenylephrine effects on cardiac contractility adenyl cyclase, and phosphorylase. PMID- 4337938 TI - Treatment of chronic mucocutaneous candidiasis of children (Candida Granuloma) with Clotrimazole. PMID- 4337940 TI - Potentiation of the bradykinin response by cysteine: mechanism of action. PMID- 4337941 TI - Response to sympathetic stimulation during angiotensin tachyphylaxis in dog's paw. PMID- 4337942 TI - Variable sulfhydryl activity toward silver nitrate by reduced glutathione and alcohol, glutamate and lactate dehydrogenases. PMID- 4337943 TI - Studies on proteolipid proteins from cerebral cortex. I. Preparation and some properties. PMID- 4337945 TI - Electron nuclear double resonance studies on heme proteins: determination of the interaction of Fe 3+ with its ligand nitrogens in metmyoglobin. PMID- 4337944 TI - The synthesis of underhydroxylated collagen by 3 T6 mouse fibroblasts in culture. PMID- 4337946 TI - [Immunity and tumors]. PMID- 4337947 TI - Carcinoma of colon simulating Crohn's disease. PMID- 4337948 TI - Reported influenza in pregnancy and subsequent cancer in the child. AB - A longitudinal study of 1,959 infants born in the first week of March 1958 to mothers who were reported to have had influenza during pregnancy revealed an incidence of cancer of 4.1 per 1,000 compared with only 0.8 per 1,000 among the 14,791 infants of mothers who had not had influenza.This increase was caused by cases of leukaemia and other neoplasms of lymphatic and haematopoietic tissue (I.C.D. 200-209) (P <0.0001).Data from the reports of the Registrar General for England and Wales were used to estimate the number of infants born in each year from 1955 to 1964 who subsequently died of cancer before 5 years of age. The rates for each year were compared with an estimate of the prevalence of influenza during the preceding winter. After allowing for the overall trend in the cancer death rate, a highly significant correlation was shown with deaths attributed to causes classified as I.C.D. 200-209 (P <0.005), but not with deaths attributed to other cancers. The increase in the risk of developing these neoplasms among children whose mothers had influenza is estimated to be not less than fourfold. Even so the risk remains small (3 to 4 per 1,000). PMID- 4337949 TI - Neuromuscular involvement in pituitary gigantism. AB - Investigation of two pituitary giants complaining of severe muscular weakness showed a peripheral neuropathy in both cases. Histological appearances suggestive of myopathy were also present in one case. PMID- 4337950 TI - Ultrastructure of perianal Paget's disease. PMID- 4337951 TI - Lung cancer: a transmission and scanning electron microscopic study. PMID- 4337952 TI - Infiltrating lobular carcinoma without lobular carcinoma in situ. PMID- 4337953 TI - Aspects of lung cancer in Jamaica. PMID- 4337954 TI - Ultrastructural aspects of papillary and sclerosing carcinomas of the thyroid. PMID- 4337955 TI - Microscopic patterns as a guide to prognosis of neuroblastoma in childhood. PMID- 4337956 TI - Cancers metastatic to the breast. PMID- 4337957 TI - Metastatic bone disease developing in patients with potentially curable breast cancer. PMID- 4337958 TI - An ultrastructural comparison of endometrial adenocarcinoma and normal endometrium. PMID- 4337959 TI - Biologically active circulating proinsulin-like materials from an islet cell carcinoma patient. PMID- 4337962 TI - Activity of dipeptidyl carboxypeptidase (angiotensin converting enzyme) in lungs of different animal species. PMID- 4337961 TI - Interactions of angiotensin, phenoxybenzamine and propranolol on noradrenaline release during sympathetic nerve stimulation. PMID- 4337960 TI - Effects of norepinephrine, theophylline and dibutyryl cyclic AMP on in vitro lipolysis of human adipose tissue in obesity. PMID- 4337963 TI - [With reference to the article by N.G. Kemaikina and G.I. Meerov: On the question of indicating the potency of ACTH in different units]. PMID- 4337964 TI - [Significance of cyclic AMP for hormone effects]. PMID- 4337965 TI - Development of tissue viral resistance in chickens following administration of interferon inducers. PMID- 4337966 TI - The role of cyclic 3',5' adenosine monophosphate in the specific cytolytic activity of lymphocytes. PMID- 4337967 TI - Kinetics and mechanism of the hydrolysis of guanosine and 7-methylguanosine nucleosides in perchloric acid. PMID- 4337968 TI - Peripheral nerve autografts. PMID- 4337969 TI - Chemical degradation of the intima from normal canine and atherosclerotic human vessels. PMID- 4337970 TI - Experimental studies on hormonal regulation of heme synthesis in bone marrow. 3. Heme synthesis in bone marrow of Wistar rats deprived of the endocrine glands simultaneously and the effects of their hormones and pituitary hormones upon the decreased heme synthesis in hypophysectomized rats. PMID- 4337971 TI - [A study of radiation hypophysectomy for prostatic cancer. 2. Endocrine function and clinical effect after raiation hypophysectomy]. PMID- 4337972 TI - The ultrastructure of herpesvirus saimiri-induced lymphoma in cotton-topped marmosets (Saguinus oedipus). PMID- 4337973 TI - Immunologically mediated glomerulitis of horses. I. Pathogenesis in persistent infection by equine infectious anemia virus. PMID- 4337974 TI - Specific enhancement of hepatoma growth using methylated bovine serum albumin and pertussis vaccine. PMID- 4337975 TI - Cardiac failure in the hamster. A biochemical and electron microscopic study. PMID- 4337976 TI - Inhibition of 3 -hydroxysteroid dehydrogenase in the rat adrenal cortex. A metabolic and morphologic study. PMID- 4337977 TI - [Virus of the "kiss disease" discovered. The hope of gaining a vaccine]. PMID- 4337978 TI - Miniature end-plate potentials at mammalian neuromuscular junctions poisoned by botulinum toxin. PMID- 4337979 TI - Direct inhibition of Col E 1 plasmid DNA replication in Escherichia coli by rifampicin. PMID- 4337980 TI - Iminoxyle radical with isocyanide as a spin label for haemoproteins. PMID- 4337981 TI - Agglutination of cells transformed by Rous sarcoma virus by wheat germ agglutinin and concanavalin A. PMID- 4337983 TI - Reflex activity of single sympathetic fibres to skeletal muscle produced by electrical stimulation of somatic and vago-depressor afferent nerves in the cat. PMID- 4337982 TI - Factors affecting the yeild of urinary estriol. PMID- 4337984 TI - The isolated frog skin epithelium: permeability characteristics and responsiveness to oxytocin, cyclic AMP and theophylline. PMID- 4337986 TI - The relative involvement of different reflex pathways in somato-sympathetic reflexes, analyzed in spontaneously active single preganglionic sympathetic units. PMID- 4337985 TI - [Negative inotropic effects of endogenous acetylcholine on ventricular myocardium of cat and chicken]. PMID- 4337987 TI - [Extensive hepatectomy (over 40 percent). 5 personal cases]. PMID- 4337988 TI - Hepatic collagen metabolism: effect of alcohol consumption in rats and baboons. AB - Long-term ethanol feeding causes collagen accumulation in livers of rats and baboons. Activity of collagen proline hydroxylase in the liver is also stimulated, and incorporation of proline into collagen hydroxyproline in rat liver slices is significantly enhanced, a result indicating that increased synthesis is responsible, in part, for the collagen accumulation. PMID- 4337989 TI - Depressed cardiac performance in sepsis. PMID- 4337990 TI - Studies on the nonneutralizable fraction of poliovirus. PMID- 4337991 TI - Isolation of temperature-sensitive mutants of murine leukemia virus. PMID- 4337992 TI - Transformation of guinea pig embryo cells by a murine sarcoma virus. PMID- 4337993 TI - Isolation of the minus strand of encephalomyocarditis virus RNA. PMID- 4337994 TI - The effect of luteinizing hormone on the ultrastructure of the Leydig cell of the chick. PMID- 4337995 TI - [Electron microscopic study of the striated muscle fibers in the pineal body of Wistar rats]. PMID- 4337996 TI - Plasma corticosteroids in primary and secondary adrenocortical insufficiency. PMID- 4337997 TI - Determination of plasma renin activity by radio-immunoassay for angiotensin II. A modification of the method of Boucher et al. PMID- 4337998 TI - Plasma lipid and lipoprotein levels in a Danish population. PMID- 4337999 TI - Changes in the lipoprotein pattern during two years following myocardial infarction. PMID- 4338000 TI - Rare tumors of the ear, nose, and throat. Third series: uncommon malignant tumors of the head and neck. PMID- 4338001 TI - Cold air temperature. Its effect on the human peripheral auditory system. PMID- 4338002 TI - Chemodectoma of the lower mediastinum. Report of a case. PMID- 4338003 TI - Correlation of DNA base composition and metabolism of Pseudomonas putrefaciens isolates from food, human clinical specimens, and other sources. PMID- 4338004 TI - A quantitative microbiological determination of 6-aminopenicillanic acid. PMID- 4338005 TI - Virus in water. II. Evaluation of membrane cartridge filters for recovering low multiplicities of poliovirus from water. AB - The efficiency of a Millitube MF cartridge filter, a membrane filter, for recovery of poliovirus from 100-gal volumes of both fresh (tap) and estuarine water was determined. In the high multiplicity of virus input-output experiments, recovery of 97% or greater of input virus was achieved in both types of water when the final concentration of divalent cation as Mg(2+) was 1,200 mug/ml and the pH was 4.5. Virus was effectively eluted from the membrane cartridge with 5x nutrient broth in 0.05 M carbonate-bicarbonate buffer at pH 9.0. Four elutions of 250 ml each were used. In the low multiplicity of virus input-output experiments under the same cationic and pH conditions, up to 67% of the input virus was recovered when the virus was further concentrated from the eluates by the aqueous polymer two-phase separation technique. The volume reduction was 126,000-190,000 to 1. The use of the combined techniques, i.e., membrane adsorption followed by aqueous polymer two-phase separation, provided a highly sensitive, simple, and remarkably reliable sequential methodology for the quantitative recovery of poliovirus occurring at multiplicities as low as 1 to 2 plaque-forming units per 5 gal of water. PMID- 4338006 TI - Radial immunodiffusion: a simple and rapid method for detection of Marek's disease antigen(s). AB - A qualitative radial immunodiffusion technique is described which detects antigen(s) in feathers from live or dead chickens infected with Marek's disease herpesvirus. Antiserum, which is incorporated into a support medium, reacts with antigen(s) in the feather tip producing a radial precipitin ring. Antigen(s) was detected in 93.3% of experimentally inoculated chickens 21 days postinoculation and in 100% of infected birds subsequently tested through 6 weeks. No antigen was detectable in the feathers of uninoculated control chickens. The technique is simple and rapid to perform. Positive tests could be detected after 1 to 2 hours of incubation. Antigen detection by the radial immunodiffusion test correlated well with other criteria of infection. This technique should have application as a laboratory research tool and as an adjunct for a rapid flock diagnosis of Marek's disease. PMID- 4338007 TI - Influence of ozone on pulmonary defense mechanisms of silicotic mice. PMID- 4338009 TI - Intussusception complicating the treatment of malignancy in childhood. PMID- 4338008 TI - Studies on histamine in the thyroid gland. PMID- 4338010 TI - Hyperparathyroidism in the Zollinger-Ellison syndrome. Influence of hypercalcemia on clinical course. PMID- 4338011 TI - Virus antibody levels in systemic lupus erythematosus. PMID- 4338013 TI - [Somatosensory transmission during voluntary movement. II. Inhibitory mechanisms in the cuneate nucleus]. PMID- 4338012 TI - Alterations in the permeability of articular cartilage by proteolytic enzymes. PMID- 4338014 TI - [Structural factors in inhibition of adenosine-3',5'monophosphate-cyclic phosphodiesterase]. PMID- 4338015 TI - [Somatosensory transmission during voluntary movement. I. Relation between lemniscal depression and functional parameters of movement]. PMID- 4338017 TI - Steroid drugs in chest disease. PMID- 4338016 TI - Viral epidemiology: the hidden universality of infection. PMID- 4338018 TI - Trapped nerves. PMID- 4338019 TI - Peripheral neuropathy and chronic liver diseases. PMID- 4338020 TI - Herpes encephalitis revisited. PMID- 4338021 TI - Bronchiolar carcinoma (alveolar cell), another great imitator; a review of 41 cases. PMID- 4338022 TI - [Immunochemical study and analytical isoelectric focusing of serum of a case of Tangier disease]. PMID- 4338023 TI - [Estimation of oxosteroids with 2,4-dinitrophenylhydrazine]. PMID- 4338024 TI - A modification of the serum glucose-6-phosphatase assay. PMID- 4338025 TI - Fructose 1,6-diphosphatase in normal and diseased human muscle. PMID- 4338026 TI - Synapse formation between dissociated nerve and muscle cells in low density cell cultures. PMID- 4338027 TI - The action of 5-bromodeoxyuridine on differentiation. PMID- 4338028 TI - [Pathogenicity of para-influenza viruses in men]. PMID- 4338029 TI - Some comments on the PAS reaction of glycogen. PMID- 4338030 TI - A new, rapid method of preparing Schiff's reagent. PMID- 4338031 TI - Lysosomes and acid phosphatases during growth and differentiation in mice: a light and electron microscope study. PMID- 4338032 TI - Rat liver 5'-nucleotidase. PMID- 4338033 TI - Phosphatase activities in rat liver before and after birth. PMID- 4338035 TI - Subungual glomus tumor: a cause of pain beneath the finger nail. PMID- 4338036 TI - [Treatment of lumbar radicular irritation syndrome using sacral epidural Novocaine and Volon A 40 injections]. PMID- 4338034 TI - Proteolysis and myelin breakdown: a review of recent histochemical and biochemical studies. PMID- 4338037 TI - Perithelial sarcoma (?) glioblastoma (?). PMID- 4338038 TI - Monstrocellular sarcoma vs giant cell glioblastoma. PMID- 4338040 TI - Magnetic resonance of isotope hybrid flavoprotein 2 H-flavoprotein ( 1 H-flavin mononucleotide). PMID- 4338039 TI - Phenotypic characterization of fi- R factors determining the restriction and modification hsp II specificity. PMID- 4338041 TI - Virus recovery in chicken cells tested with Rous sarcoma cell DNA. PMID- 4338042 TI - Inhibitor of the DNA-dependent DNA polymerase of some RNA tumour viruses in feline sera. PMID- 4338043 TI - Regulation of metabolism of 25-hydroxycholecalciferol by kidney tissue in vitro by dietary calcium. PMID- 4338045 TI - Uptake of radioactive phosphate into rat liver lysine-rich histones and phosphoproteins. PMID- 4338044 TI - Pharmacology and mechanisms of action of diphenylhydantoin. PMID- 4338046 TI - Pulmonary activation and degradation of angiotensin I: a dual enzyme system. PMID- 4338047 TI - Proton nuclear magnetic resonance and fluorescence studies of the interaction between inhibitors and horse liver alcohol dehydrogenase-reduced pyridine coenzyme binary complex. PMID- 4338048 TI - Augmentation of erythrocyte iron uptake in post-hypoxic mice by the administration of N 6 , O 2 '- -dibutyryl cyclic adenosine 3',5'-monophosphate (dBcAMP) 1,2,3. PMID- 4338049 TI - Lipolysis in human adipose tissue: comparison of human pituitary hormones with other lipolytic agents. PMID- 4338051 TI - Free urinary cortisol as a representative steroid of the urinary Porter-Silber chromogens. PMID- 4338050 TI - Studies of the changes in adrenal corticosterone in mice treated with dexamethasone, chlorpromazine, morphine and codeine: development of an assay for corticotrophin-releasing factor. PMID- 4338053 TI - Responses from isolated individual semicircular canal ampullae in frog. PMID- 4338052 TI - Effect of 3':5'-cyclic AMP on nuclear and mitochondrial RNA synthesis of rat adrenocortical cells. PMID- 4338054 TI - Dual effects of adrenomimetic amines at the neuromuscular junction. PMID- 4338055 TI - Corrosive injury of the stomach and esophagus by nonphosphate detergents. An experimental study. PMID- 4338056 TI - Cystosarcoma phylloides. Treatment by subcutaneous mastectomy with immediate prosthetic implantation. PMID- 4338057 TI - [Effect of polymyxin M on transduction of drug resistance factors in Staphylococcus aureus]. PMID- 4338058 TI - [Presence of nuclear inclusions in the cells of the human placenta]. PMID- 4338059 TI - Immunity to influenza in ferrets. II. Influence of adjuvants on immunization. PMID- 4338060 TI - The fibrogenic effects of mineral dusts injected into the pleural cavity of mice. PMID- 4338061 TI - Polykaryocytosis and replication of mouse hepatitis virus in peritoneal macrophages. PMID- 4338062 TI - The release of vesicles from platelets following adhesion to vessel walls in vitro. PMID- 4338063 TI - Reovirus pathogenesis and the identity of REO3MH. PMID- 4338064 TI - Assay of the immune inhibitor in classic haemophilia: application of virus antibody reaction kinetics. PMID- 4338065 TI - Late discharges in dog's sympathetic ganglia. PMID- 4338066 TI - The relationship between pH and aerobic glycolysis in human and canine erythrocytes. PMID- 4338067 TI - Relationship of duodenal calcium-binding protein to calcium absorption in the laying fowl. PMID- 4338068 TI - Changes in the activity of the limbic-hypothalamic neural pathways under the repeated immobilization stress. PMID- 4338069 TI - Hypotriglycedemic action of synthetic ACTH. PMID- 4338070 TI - [Metastasizing islet cell carcinoma. II. Studies on insulin secretion in vitro]. PMID- 4338071 TI - [On the gastrostimulating mechanism of insulin]. PMID- 4338072 TI - Color-coded cells in goldfish, cat, and rhesus monkey. PMID- 4338073 TI - Processing of intensity and wavelength information by the visual system. PMID- 4338075 TI - The retinal input to the superior colliculus in the cat. PMID- 4338074 TI - Color opponency from fovea to striate cortex. PMID- 4338076 TI - Spatial aftereffects. PMID- 4338077 TI - Membranes of mammary gland. II. 5'-Nucleotidase activity of bovine mammary plasma membranes. PMID- 4338078 TI - A selective oleic acid albumin agar medium for tubercle bacilli. PMID- 4338079 TI - [Study on the neurohumoral mechanism of the thermoregulation: effects of ACTH and 5-hydroxytryptamine upon the body temperature]. PMID- 4338080 TI - The effect of diphenylamine on terminal respiration in bloodstream and culture forms of Trypanosoma brucei. PMID- 4338081 TI - The induction of endocytosis in starved Tetrahymena pyriformis. PMID- 4338082 TI - [Experimental studies on the uterine muscular actomyosin-ATPase activity of the rat under various endocrinological environments]. PMID- 4338083 TI - [Enzymatic activity of appendicular tissues in acute appendicitis]. PMID- 4338084 TI - The role of inhibition and adaptation in sensory information processing. PMID- 4338085 TI - Holographic aspects of temporal memory and optomotor responses. PMID- 4338088 TI - [Attempt at treating multiple sclerosis with delayed-action corticotropin]. PMID- 4338086 TI - Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 29-1972. PMID- 4338090 TI - [Polyneuropathy in Hodgkin's disease]. PMID- 4338089 TI - [Comparison of results of echoencephalography, angiography and pneumoencephalography]. PMID- 4338091 TI - [Arteriovenous angioma of the brain as a cause of migraine-like headaches of many years duration]. PMID- 4338092 TI - [Coexistence of various neurological peripheral syndromes in a patient with diabetes and syphilis]. PMID- 4338093 TI - [Electron spin resonance spectra intensity of the human hair--studies on the characteristics of E.S.R. spectra intensity of the human hair, especially the individualities of radiation effects]. PMID- 4338094 TI - Malignant mixed tumor of the lacrimal gland. Case report. PMID- 4338095 TI - [Zinc and experimental caries in the rat]. PMID- 4338096 TI - Iodine-125-labeled antibody to viral antigens: binding to the surface of virus infected cells. AB - The specific binding of iodine-125-labeled antibody to viral antigens can be used to detect newly synthesized viral antigens and determine the time of appearance of these antigens on the surface of infected cells. Incubation of infected cells with unlabeled antibody to viral antigens specifically blocks the attachment of labeled antibody, and by this inhibition technique the titer of unlabeled antibody to viral antigens can be calculated. The attachment of the labeled antibody to virus-infected cells offers an objective and sensitive method of detecting viral antigens and measuring antibody to virus. PMID- 4338097 TI - Polyadenylic acid sequences in the virion RNA of poliovirus and Eastern Equine Encephalitis virus. AB - Poliovirus virion RNA contains a single covalently bound sequence of polyadenylic acid which is approximately 49 nucleotides long. A single, slightly longer polyadenylic acid sequence is contained in Eastern Equine Encephalitis virus RNA. Since these viruses are otherwise dissimilar these sequences may play a common role in viral replication, possibly in translation of the viral RNA. PMID- 4338098 TI - Cicatricial stricture in intestinal amebiasis: a review of 121 cases of intestinal amebiasis. PMID- 4338099 TI - Cylindromas of the head and neck. PMID- 4338100 TI - [Experimental pathogenicity in mice of poliovirus 2 strains]. PMID- 4338101 TI - Carcinoma of the male breast. PMID- 4338102 TI - The effects of continuous-flow washing on stored red blood cells. PMID- 4338104 TI - [Acute polyuria--reaction on hemodynamic constriction situations]. PMID- 4338105 TI - Antibodies to the Epstein-Barr virus in kidney transplant recipients. PMID- 4338103 TI - Anti- -lipoprotein activity of human monoclonal immunoglobulins. PMID- 4338106 TI - Antibody levels to parainfluenza, herpes simplex, varicella-zoster, cytomegalo virus, and measles virus in patients with connective tissue diseases. PMID- 4338107 TI - Calcium pyrophosphate deposits in synovial membrane. PMID- 4338108 TI - [Application of infrared absorption spectroscopy to examination of drugs and their preparations. XXI. Determination of the mixture of polymorphic forms of silicon dioxide (cristobalite and quartz) by potassium bromide disc method]. PMID- 4338109 TI - Dipeptidyl aminopeptidase I: application in sequencing of peptides. PMID- 4338110 TI - The mode of action of batrachotoxin. PMID- 4338111 TI - Drugs having a toxic effect on the optic nerve. PMID- 4338112 TI - Prephytoene pyrophosphate. A new intermediate in the biosynthesis of carotenoids. PMID- 4338113 TI - Viomycin. II. The structure of the chromophore. PMID- 4338114 TI - Studies related to penicillins. VII. The structure of the epimers derived from 6 substituted penicillanic acids. PMID- 4338115 TI - Deficient renal cyclic adenosine 3'-5' monophosphate production in nephrogenic diabetes insipidus. PMID- 4338116 TI - Effects of metyrapone and corticotropin infusion on cortisol disappearance rate in man. PMID- 4338118 TI - Short- and long-term effects of estrogen and synthetic anabolic hormone in postmenopausal osteoporosis. AB - In 29 women with postmenopausal osteoporosis, the proportion of total bone surface undergoing resorption or formation was evaluated by microradiography of iliac crest biopsy samples before and after short-term (2(1/2)-4 months) and long term (26-42 months for estrogen and 9-15 months for anabolic hormone) treatment. After estrogen administration, values for bone-resorbing surfaces decreased, although less prominently after long-term than after short-term therapy. The magnitude of this decrease was positively correlated with the pretreatment value for bone-resorbing surfaces (P < 0.001). When the pretreatment value for bone resorbing surfaces was used as a covariable, estrogen and anabolic hormone appeared to be equally effective. For bone-forming surfaces, short-term therapy with either hormone had no effect but long-term therapy significantly decreased the values. Serum immunoreactive parathyroid hormone (IPTH) increased significantly after estrogen therapy; the change in IPTH was inversely related to the change in serum calcium (P < 0.001, sign test). We conclude that the primary effect of sex hormones in postmenopausal osteoporosis is to decrease the increased level of bone resorption, perhaps by decreasing the responsiveness of bone to endogenous parathyroid hormone. However, this favorable effect, at least in part, is negated after long-term treatment by a secondary decrease in bone formation. Our data are consistent with the concept that the maximal benefit that can be derived from sex hormone therapy in postmenopausal osteoporosis is arrest or slowing of the progession of bone loss. PMID- 4338117 TI - Effect of clofibrate on lipoprotein metabolism in hyperlipidemic rats. AB - The effects of clofibrate administration were studied in rats made hyperlipidemic by the feeding of diets high in sucrose. Within 12 hr of administration of clofibrate, there was a marked decrease in the concentration of serum high density lipoproteins but no change in the concentrations of the low and very low density lipoproteins. Between 2-4 days of treatment, the concentration of the very low density lipoproteins decreased whereas that of the low density lipoproteins was unchanged. In addition, the composition of the very low density lipoproteins was altered by clofibrate administration with a decrease in triglyceride and an increase in phospholipid content. The synthesis of high density lipoproteins, as measured by the incorporation of labeled amino acids, decreased within 12 hr of treatment. The synthesis of the very low density lipoproteins was increased during the first 2 days and then decreased slightly. The synthesis of low density lipoproteins did not change. The rate of removal of very low density lipoproteins was measured at various times from 0.5 to 8 days of treatment and was found to be elevated. It was concluded that in the hyperlipidemic sucrose-fed rat, administration of clofibrate results in a reduced level of very low density lipoproteins which may be due in part to enhancement of the rate of removal of this fraction. PMID- 4338119 TI - Metabolism of adrenal cholesterol in man. I. In vivo studies. AB - The kinetics of plasma and adrenal cholesteral equilibration were analyzed in patients undergoing bilateral adrenalectomy for generalized mammary carcinoma. A biological model is proposed to help in the understanding of adrenal cholesterol physiology. It comprises two intracellular compartments: (1) A compartment of free adrenal cholesterol which is small (of the order of 17 mg) but turns over very fast; it is renewed approximately 8 times per day: 3 times by the inflow of free plasma cholesterol, and 5 times by the hydrolysis of esterified adrenal cholesterol, the contribution of adrenal cholesterol synthesis appearing to be relatively small. (2) A compartment of esterified adrenal cholesterol which is 20 times larger; it is constantly renewed by in situ esterification and hydrolysis with a daily fractional turnover rate of the order of 0.25. The direct and selective accumulation of plasma cholesteryl esters is practically absent. Only free adrenal cholesterol returns to plasma, mostly after conversion into steroid "hormones."However small the synthesis of adrenal cholesterol may be, it seems more important in the zona "reticularis." On the other hand, the inflow of plasma cholesterol and the turnover of the free adrenal compartment tend to be faster in the zona "fasciculata." The equilibration of plasma and adrenal cholesterol can proceed unmodified under conditions of ACTH suppression. In one patient with Cushing's disease the size of the two adrenal compartments was clearly increased but their equilibration with plasma cholesterol proceeded normally. In another patient the kinetics of hydrocortisone corresponded to those of free adrenal cholesterol in the control studies. PMID- 4338120 TI - Metabolism of adrenal cholesterol in man. II. In vitro studies including a comparison of adrenal cholesterol synthesis with the synthesis of the clucocorticosteroid hormones. AB - The synthesis of adrenal cholesterol, its esterification and the synthesis of the glucocorticosteroid hormones were studied in vitro on human adrenal tissue. It was found that the synthesis of adrenal cholesterol may normally be small in the zona "fasciculata," particularly when compared with the synthesis of the glucocorticosteroid hormones, that it is several times higher in the zona "reticularis" where esterified cholesterol is less abundant, and that under ACTH stimulation it increases strikingly and proportionally to the degree of esterified adrenal cholesterol depletion. ON THE OTHER HAND, THE RELATIVE RATE OF ESTERIFICATION AS WELL AS THE CONCENTRATION OF FREE ADRENAL CHOLESTEROL ARE REMARKABLY STABLE: they do not differ according to the adrenal zonation and are unaffected by ACTH. Furthermore, from a qualitative point of view, the relative proportions of Delta(1) and Delta(2) cholesteryl esters formed in situ are similar to those anticipated from their relative concentrations, suggesting that the characteristic fatty acid distribution of the adrenal cholesteryl esters results from an in situ esterification rather than from a selective uptake of the plasma cholesteryl esters. Besides, the in vitro esterification reveals a propensity to the formation of the most unsaturated cholesteryl esters. Regarding hydrocortisone and corticosterone, their synthesis tends to be more elevated in the zona "fasciculata." Despite its higher cholesterol concentration the zona "fasciculata" should not therefore be viewed as a quiescent functional complement to the zona "reticularis" and the cortical distribution of glucocorticosteroid hormone synthesis is quite distinct from that of adrenal cholesterol synthesis. PMID- 4338121 TI - Studies of the control of plasma aldosterone concentration in normal man. I. Response to posture, acute and chronic volume depletion, and sodium loading. AB - The peripheral plasma levels of aldosterone, renin activity (PRA), potassium, corticosterone, cortisol, and in some cases angiotensin II, were measured in normal subjects undergoing postural changes, acute diuretic-induced volume depletion, and alterations in dietary sodium. On a 10 mEq sodium/100 mEq potassium intake, subjects supine for 3 consecutive days had identical diurnal patterns of PRA, angiotensin II, aldosterone, cortisol, and corticosterone, with peaks at 8 a.m. and nadirs at 11 p.m. With an increase in sodium intake to 200 mEq, plasma levels of aldosterone and PRA fell to one-third their previous levels but the diurnal pattern in supine subjects was unchanged and again parallel to that of cortisol and corticosterone. There was no diurnal variation of plasma potassium on either sodium intake in the supine subjects. On a 10 mEq sodium/100 mEq potassium intake, supine 8 a.m. plasma aldosterone (55+/-7 ng/100 ml) and PRA (886+/-121 ng/100 ml per 3 hr) increased by 150-200% after subjects were upright for 3 hr. However, even though the patients maintained an upright activity pattern, there was a significant fall in plasma aldosterone to 33+/-5 ng/100 ml at 11 p.m. Potassium levels varied in a fashion parallel to aldosterone and PRA. Plasma cortisol and corticosterone had a diurnal pattern similar to that found in supine subjects. In response to acute diuretic-induced volume depletion, the nocturnal fall in aldosterone levels did not occur. The 11 p.m. value (102+/-20 ng/100 ml) and the 8 a.m. value postdiuresis (86+/-15 ng/100 ml) were both significantly greater than the prediuresis levels. PRA showed a similar altered pattern while potassium levels fell throughout the day. In some but not all studies, changes in plasma aldosterone coincided with changes in plasma cortisol, corticosterone, and/or potassium. However, in all studies, changes in plasma aldosterone were invariably associated with parallel changes in plasma renin activity and/or angiotensin II levels. These findings support the concept that PRA is the dominant factor in the control of aldosterone when volume and/or dietary sodium is altered in normal man. PMID- 4338123 TI - The interactions of thiazide diuretics with parathyroid hormone and vitamin D. Studies in patients with hypoparathyroidism. AB - In order to clarify the mechanisms of thiazide diuretic-induced hypocalciuria, the effect of a thiazide was studied for 7 days in seven patients with hypoparathyroidism on Vitamin D and one on calcium infusion, and seven euparathyroid patients with hypercalciuria. In the control group, calcium excretion (mg/24 hr) fell by 44% from 415 to 232 within 4 days and remained at this level. Plasma total calcium corrected for total protein did not change. In the hypoparathyroid group, calcium excretion fell by 11% from 351 to 311 and then returned to the base line level. Plasma total calcium (mg/100 ml) increased from 10.09 to 10.88, 11.29 and 10.77 at the end of the 2nd, 4th, and 7th day of thiazide administration. In the patient having i.v. calcium and no Vitamin D, neither plasma nor urinary calcium changed significantly. In both groups sodium excretion increased on the first 2 days and fell to or below base line level thereafter. Urinary phosphate, magnesium, and potassium increased, plasma phosphate rose, and magnesium and potassium fell. It is concluded that: (a) The hypocalciuric effect of thiazides requires the presence of parathyroid hormone and is not solely a result of sodium depletion. (b) The hypercalcemic effect of thiazides in hypoparathyroidism is due to increased release of calcium from bone and requires the presence of a pharmacologic dose of Vitamin D. (c) Thiazides enhane the action of parathyroid hormone on bone and kidney; Vitamin D can replace parathyroid hormone in this interaction in bone but not in kidney. PMID- 4338122 TI - Studies on the interaction between collagen and a plasma kallikrein-like activity. Evidence for a surface-active enzyme system. AB - This study has demonstrated that collagen particles, after exposure to platelet poor human plasma and subsequent washing, generate a kinin-like agent when incubated with prekinin substrate. The binding of kinin-generating activity to collagen in the plasma collagen incubation mixture occurs rapidly, whereas the loss of this activity in the incubation mixture occurs relatively slowly. The Hageman factor appeared to be necessary for the surface-bound kinin-generating activity, as this activity was absent in collagen exposed to Hageman factor deficient plasma. These studies have partially characterized the plasma-derived enzymatic activity bound to collagen. Incubation of collagen with plasma caused a concentration-dependent reduction in the kinin-producing activity which was generated by the addition of ellagic acid, a known activator of plasma kallikrein. The kinin-inducing activity bound to collagen is inhibited by soybean trypsin inhibitor, Trasylol, serum C1 inactivator and the plasma alpha(2) macroglobulin, but not by lima bean trypsin inhibitor. An eluate prepared from plasma-treated collagen, when compared with purified plasma kallikrein, shared a similar inhibitor profile. Selective chemical blockage of the free carboxyl groups on the collagen molecule, or heat denaturation, inactivated the ability of the collagen to generate kinin-like activity after incubation with plasma. Removal of the collagen telopeptides or blockage of the free amino groups failed to affect the collagen-plasma interaction. The binding of partially purified plasma kallikrein to collagen was found to have similar structural and chemical requirements. These data indicate that there is a structural and chemical specificity for the activation and binding of plasma kallikrein-like activity by collagen. These studies suggest that a plasma kallikrein may function as a surface-bound enzyme system. PMID- 4338125 TI - Dihydrotachysterol: a calcium active steroid not dependent upon kidney metabolism. AB - The activity of dihydrotachysterol and cholecalciferol was determined in nephrectomized or sham-operated vitamin D-depleted rats using in vitro transport of calcium and phosphate by everted intestinal preparations as the index of physiologic response. The activity of dihydrotachysterol was not reduced by absence of the kidneys whereas that of cholecalciferol was markedly inhibited so that at least a 10-fold greater dose of the latter was necessary to produce an equivalent effect in the nephrectomized rat as in the control. Dihydrotachysterol is therefore equipotent with cholecalciferol in the anephric rat although much less active in the intact animal. PMID- 4338124 TI - The appearance of lecithin- 32 P, synthesized from lysolecithin- 32 P, in phagosomes of polymorphonuclear leukocytes. AB - Rabbit polymorphonuclear leukocytes ingesting paraffin oil particles stabilized with albumin, converted more lysolecithin-(32)P (added to the medium as an albumin complex) to cellular lecithin than did control cells. Almost all of the increment in leukocyte lecithin-(32)P is found in association with the isolated phagocytic vacuoles. About half of lecithin-(32)P of granulocytes incubated first with lysolecithin-(32)P and then reincubated with paraffin particles in a nonradioactive medium is transferred from a sedimentable (presumably membrane) fraction to the phagosomes. Isolated phagosomes or granules by themselves are capable of acylating lysolecithin. The main source of lysolecithin-(32)P for synthesis of cellular lecithin-(32)P, however, appears to be extracellular rather than lysolecithin-(32)P within the cytoplasm or the phagocytic vacuole. We interpret our findings therefore as indicating that lecithin-(32)P in the phagosomes derives chiefly from the outer membrane. PMID- 4338126 TI - Secretion by ependymal cells of the neurohypophysis and saccus vasculosus of Polypterus ornatipinnis (Osteichthyes). PMID- 4338127 TI - Ultrastructural observations on oogenesis in Drosophila. PMID- 4338128 TI - The mucigenous glandular mucosa in the comples stomach of two new-world camelids, the llama and guanaco. PMID- 4338130 TI - The clinical specialist: a role model for students during their psychiatric experience. PMID- 4338129 TI - The token economy: a challenge to nursing. PMID- 4338131 TI - Contact vs contract; the process of taming. PMID- 4338132 TI - Coalition attempts in group therapy--indicators of inclusion and group cohesion problems. PMID- 4338133 TI - Ward environment and the severely regressed patient. PMID- 4338134 TI - The right to old age. PMID- 4338135 TI - Speaking out on: the right to care and treatment--an action turning point in Alabama. PMID- 4338136 TI - Enzyme lack--cause of schizophrenia? PMID- 4338137 TI - Negative attitudes in caring for the aged. PMID- 4338138 TI - Disturbance in language and thought. PMID- 4338140 TI - [Diagnosis and differential diagnosis of Marek's disease in chickens. 1. Problems, etiology and manifestations]. PMID- 4338139 TI - Further studies on induced respiratory viral infection of vervet monkeys (Cercopithecus aethiops). PMID- 4338141 TI - [Concentration and relation of plasma 11-hydroxycorticosteroids and eosinophilic granulocytes following procortane injections in calves]. PMID- 4338142 TI - Poliovirus replication during HeLa cell life cycle. PMID- 4338143 TI - An antigen in human breast cancer sera related to the murine mammary tumour virus. PMID- 4338144 TI - [Clinical morphological changes in radiotherapy of juvenile angiofibroma of the skull base]. PMID- 4338145 TI - Breast lesions in blacks. PMID- 4338146 TI - Effect of drugs on carcinoma of the breast in tissue culture. PMID- 4338147 TI - [Characteristics of the physiological action of ionized air]. PMID- 4338148 TI - [Treatment of peripheral nerve injuries]. PMID- 4338149 TI - [Arteriographic radiodiagnostics in surgical emergency situations]. PMID- 4338150 TI - Changes in muscle characteristics in growing pigs: histochemical and electron microscopic study. PMID- 4338152 TI - [Radiological aspects of synovial sarcoma. Analysis of 41 cases]. PMID- 4338151 TI - Proliferation of the retinal pigment epithelium over malignant choroidal tumors. A light and electron microscopic study. PMID- 4338154 TI - [Effect of acoustic stimulation on behavior of hematic cortisol in man]. PMID- 4338153 TI - Psychiatric aspects of disseminated lupus erythematosus in Hong Kong Chinese- report of three cases. PMID- 4338155 TI - Carcinoma of the cervix and herpesvirus. PMID- 4338156 TI - Isolation of herpes virus from erythema multiforme. PMID- 4338157 TI - Psychrotrophic properties of Listeria monocytogenes. PMID- 4338158 TI - Cell-fusion properties of Sendai virus prepared by polyethylene-glycol precipitation. PMID- 4338160 TI - Isolated analdosteronism with deficiency of renin and angiotensin. PMID- 4338159 TI - Rotational tomography of hilar and mediastinal masses including vascular abnormalities. PMID- 4338161 TI - A city-wide, community-based aftercare program. PMID- 4338163 TI - Stability predictions for pharmaceutical preparations. PMID- 4338162 TI - [Titration of kava-kava extracts]. PMID- 4338164 TI - The yolk of Latimeria chalumnae Smith. PMID- 4338165 TI - The biological role of melanin. I. New concepts and methodical approaches. PMID- 4338166 TI - Hemagglutination inhibiting activity of human serum protein fractions towards Reovirus type 2. PMID- 4338167 TI - Isozyme variations in human cells grown in vitro. VII. Subcellular distribution of amino acid naphthylamidases. PMID- 4338169 TI - Management of brain tumors. PMID- 4338168 TI - Inoculation of hamsters with a temperature sensitive (ts) mutant of parainfluenza 3 virus. AB - The multiplication pattern of a temperature-sensitive (ts) mutant of bovine parainfluenza 3 virus was studied in hamsters and compared with that of a virulent virus strain. The ts mutant was recovered regularly from the nasal mucosa and not from the lungs, whereas the virulent virus multiplied in the lungs as well as in the nasal mucosa.The serological response induced by the mutant was comparable to that obtained after inoculation of the virulent virus.This ts mutant may be a potential candidate for a live intranasal vaccine against bovine parainfluenza 3 infection. PMID- 4338170 TI - Phospholipid and cholesterol content of ventricular tissue from the cardiomyopathic Syrian hamster. PMID- 4338171 TI - Phospholipids, adenylate cyclase, and the heart. PMID- 4338172 TI - Plasma cortisol and adrenocorticotrophic hormone in normal men and non-pregnant women, normal pregnant women and women with pre-eclampsia. PMID- 4338173 TI - The prevention of isoproterenol desensitization and isoproterenol reversal. PMID- 4338174 TI - Potentiation of adrenal medullary responses to angiotensin by (4,4' biphenylenebis-(2-oxoethylene)) bis((2,2-diethoxyethyl)-dimethylammonium bromide) (DMAE) in vitro. PMID- 4338176 TI - Metastatic cystosarcoma phyllodes: a case report and review of the literature. PMID- 4338177 TI - Occurrence of simian virus 40 (SV40)-reacting antibodies in sera of some patients with prostatic cancer. PMID- 4338175 TI - The onset and development of transmission in the chick ciliary ganglion. AB - 1. The onset and development of transmission has been studied electro physiologically in the isolated chick ciliary ganglion from Stage 25 (Hamburger & Hamilton, 1951) until 28 days after hatching. Ultrastructure of the synapses was concomitantly investigated.2. Synaptic transmission began at Stage 26(1/2) and was 100% in both cell groups, ciliary and choroid, by Stage 33. It was initially chemical until Stage 41 when effective electrical coupling first appeared in the ciliary population. The proportion of electrically transmitting synapses increased to 80% by 1-2 days post-hatching.3. Few morphological synapses were present at Stage 33(1/2) when all ganglion cells were transmitting. A scarcity of synaptic vesicles persisted until late in embryonic development when all ciliary cells possessed calyces. At hatching the calyces were filled with synaptic vesicles.4. Initial synaptic contacts were by fine terminal branches often on the intricate processes of early ganglion cells. Calyces formed from Stage 36(1/2) and there was a concomitant retraction of ganglion cell processes, so that by Stage 40 all ciliary cells had simple calyces. The calyx was a transitory structure, which from the first week post-hatching began to break up into a cluster of boutons.5. Chemical post-synaptic potentials (PSPs) were at Stage 40 long (30 x the membrane time constant) and further prolonged by eserine. By Stage 43, PSPs had become markedly shortened and were unaffected by eserine. No simple explanation can be offered for the changes in PSP time course and sensitivity to anticholinesterases during development.6. Intracellular records from Stage 40 ciliary cells, which all possess calyces, showed 1-2 mV amplitude, diphasic, fast decaying electrical coupling potentials (CPs). Later in development the CPs became 20-40 mV amplitude, more slowly decaying and monophasic. This seemed to be correlated with faster presynaptic conduction velocities and myelination of the cell soma. Such changes in CPs may reflect a shift from capacitative to more resistive coupling and point to several factors contributing in varying degrees to the electrical transmission.7. Presynaptic fibres innervating ciliary cells were from the start of lower threshold and faster conduction velocity than those innervating ciliary cells, as occurred in the adult. It is concluded that these preganglionic fibres were probably specified by the time transmission starts and that they selectively innervated the proper post-synaptic cells. PMID- 4338178 TI - Possible role of cyclic-3', 5'-adenosine monophosphate in the release of catecholamines from the adrenal medulla. PMID- 4338180 TI - [Experimental studies on the opacification of the organs by Popiodol Suspension]. PMID- 4338179 TI - Proteins synthesized by a non-induced bacteriocinogenic factor in minicells of Escherichia coli. PMID- 4338181 TI - Neuroblastoma clones: prostaglandin versus dibutyryl cyclic AMP, 8-benzylthio cyclic AMP, phosphodiesterase inhibitors and x-rays. PMID- 4338182 TI - Inhibition of angiotensin I-initiated hemodynamic changes in anesthetized dogs by a synthetic nonapeptide. PMID- 4338183 TI - Inhibition of pressor effects of angiotensin I and augmentation of depressor effects of bradykinin by synthetic peptides. PMID- 4338184 TI - Liver microsomal glucose-6-phosphatase: protection by inhibitors and substrates against thermal inactivation. PMID- 4338185 TI - The effect of medroxyprogesterone on cells of the pituitary pars distalis. PMID- 4338186 TI - On a possible relationship of cyclic AMP to the mechanism of action of nerve growth factor. PMID- 4338187 TI - Prophylactic and therapeutic use of poly(I)-poly(C) (poly-D-lysine) against herpesvirus encephalitis in mice. PMID- 4338188 TI - Immunodepression by oncogenic viruses. PMID- 4338189 TI - Clinical significance of the EB herpesvirus infection in man. PMID- 4338190 TI - Parainfluenza-5 virus. Infection of man and animal. PMID- 4338191 TI - The distribution and significance of multiploid virus particles. PMID- 4338192 TI - Preface: progress in virology, 1972. PMID- 4338193 TI - [The significance of renin-angiotensin-aldosterone system (RAA) in pathophysiology and diagnosis]. PMID- 4338194 TI - The effect of small amounts of aluminium, carbon and carborundum on the development of silicosis and asbestosis. PMID- 4338195 TI - [The liver in chronic progressive polyarthritis]. PMID- 4338196 TI - Reversion of murine sarcoma virus transformed mouse cells: variants without a rescuable sarcoma virus. AB - Murine sarcoma virus transformed mouse 3T3 cells, which are negative for murine leukemia virus and which yield sarcoma virus after superinfection with murine leukenmia virus, spotaneously give rise to flat variants front which murine sarcoma virus can no longer be rescued. The revertants support leukemia viruis growth and show an enhanced sensitivity to murine sarcoma superinfection and, like normal cells, do not release RNA-dependent DNA polymerase activity. Because revertants could be obtained with high frequency from progeny of single transformed cells, each cell that containts the sarconma virus genome seems to have the capacity to suppress or eliminate an RNA tumor virus native to its species of origin. PMID- 4338198 TI - The treatment of optic neuritis. PMID- 4338197 TI - Gamma-aminobutyric acid: role in primary afferent depolarization. AB - The effects of putative transmitters on the primary afferent terminals were studied in the magnesium-treated, isolated spinal cord of the frog. Gamma aminobutyric acid and glutamic acid reversibly depolarized primary afferent terminals and increased their excitability, whereas glycine produced weak and variable effects. Bicuculline and picrotoxin, which reduce primary afferent depolarization, reversibly antagonized the gamma-aminobutyric acid-mediated responses but had little effect on those produced by either glutamic acid or glycine. The glutamic acid- and the gamma-aminobutyric acid-induced depolarizations remained in the absence of external chloride but disappeared in the absence of external sodium. These results support the hypotheses that gamma aminobutyric acid is the transmitter mediating the synaptic depolarization of primary afferent terminals and that sodium is the predominant ion involved. PMID- 4338199 TI - Calcium challenge in the Zollinger-Ellison syndrome. PMID- 4338200 TI - The role of the microbial flora in acute gastric stress ulceration. PMID- 4338201 TI - Horizons in gastrointestinal research. PMID- 4338202 TI - Autoradiographic studies on cell proliferation during splenomegaly induced by Bordetella pertussis in mice. PMID- 4338203 TI - Ultrastructure of gallbladder with cholesterolosis. PMID- 4338204 TI - [Transsphenoidal microsurgery technic in the small adenoma and microadenomas of the pituitary gland]. PMID- 4338205 TI - Ontogenetic alterations of vitamin B 6 metabolism in rat brain--evidence of acceleration of its turnover rate. PMID- 4338206 TI - Wilms' tumor associated with venous thrombosis and consumption coagulopathy. PMID- 4338207 TI - Microbodies in experimentally altered cells. IX. The fate of microbodies. AB - Male rats were given 0.25% CPIB (ethyl chlorophenoxyisobutyrate) for 4 weeks at which time their liver cells showed the typical increase in number of microbodies (peroxisomes). During the first week after withdrawal of CPIB and simultaneous injection of allylisopropylacetamide (AIA), an inhibitor of catalase synthesis, the microbody matrix, in peroxidase preparations, showed marked decrease in electron opacity. In liver cells of rats from which CPIB was withdrawn but which were not given AIA, there were interruption in the limiting membrane and almost total loss of microbody matrix within 3 days. Simultaneous with the loss of matrix content, the hepatic catalase activity decreased from an average 80 units/mg protein to less than 10 units/mg protein. In liver cells of Mastomys natalensis, a multimammate rodent, withdrawal of CPIB was associated with the frequent occurrence of bare microbody nucleoids situated free in the hyaloplasm. The ultrastructural observations and the associated decrease in catalase activity suggest that one means of disposal of microbodies is by rather rapid dissolution or leakage of their matrix enzymes into the surrounding hyaloplasm. PMID- 4338208 TI - Squamous metaplasia of the opening of bronchial glands. AB - The major bronchi of swine, a dog and rabbits were examined with a scanning electron microscope and the fine structure of the openings of bronchial glands were studied three-dimensionally. The smallest areas of squamous metaplasia involved the duct openings. By examining serial sections with the light and transmission electron microscopes these early lesions were found localized at the opening of the bronchial gland duct. Cells intermediate to goblet and squamous cells were present in these lesions. Squamous metaplasia starting at this particular location is probably common and metaplasia can be an intracellular process. PMID- 4338209 TI - [Diabetic necrobiosis lipoidica. Histochemical and ultrastructural study of a case]. PMID- 4338212 TI - Factors affecting survival of patients with gallbladder neoplasms. PMID- 4338210 TI - [Insulin-secreting pancreatic tumor with amyloid stroma associated with A cell adenomas. Histology and ultrastructure]. PMID- 4338211 TI - Treatment of vitamin D-resistant rickets with 25-hydroxycholecalciferol. PMID- 4338213 TI - [Mixed tumors of the minor salivary glands. Histochemical studies]. PMID- 4338214 TI - The cellular analysis of liver carcinogenesis. VI. Growth and ultrastructural characteristics of n-2-fluorenylacetamide hyperplastic liver nodule cells grown in vitro. PMID- 4338215 TI - Arterial thrombosis induced by hypertension and fatty acid mobilization. PMID- 4338216 TI - Lipid and cholesterol metabolism in Alaskan Arctic Eskimos. PMID- 4338217 TI - Extramammary Paget's disease. Enzyme histochemical and electron microscopic study. PMID- 4338218 TI - Laminated mitochondrial inclusions in hepatocytes of liver biopsies. PMID- 4338219 TI - Malacoplakia of the gastrointestinal tract. PMID- 4338220 TI - Comparative ultrastructural studies on the cores of herpes simplex and varicella zoster viruses. PMID- 4338221 TI - A survey of drug resistance in salmonellae isolated from animals in England and Wales. PMID- 4338223 TI - Transformation of cells in culture from children with chromosomal and immune deficiency disorders. PMID- 4338222 TI - The levels of the nicotinamide-adenine dinucleotides in the tissues of rabbits and rats after chronic exposure to carbon disulphide. PMID- 4338224 TI - Simultaneous bilateral primary breast carcinoma in the male. PMID- 4338225 TI - Stimulation of leukocyte adenyl cyclase by hydrocortisone and isoproterenol in asthmatic and nonasthmatic subjects. PMID- 4338226 TI - Multiplicity of adenosine 3',5'-monophosphate-dependent protein kinases from rat liver and mode of action of nucleoside 3',5'-monophosphate. PMID- 4338227 TI - Adenosine 3',5'-monophosphate-dependent protein kinase from adipose tissue. PMID- 4338228 TI - Human -fetoprotein. Isolation, characterization, and demonstration of microheterogeneity. PMID- 4338229 TI - Biosynthesis of chondroitin sulfate proteoglycan. Xylosyl transfer to Smith degraded cartilage proteoglycan and other exogenous acceptors. PMID- 4338230 TI - Reversible inhibition by histidinol of protein synthesis in human cells at the activation of histidine. PMID- 4338231 TI - Conversion of exposed cytidine residues to uridine residues in Escherichia coli formylmethionine transfer ribonucleic acid. PMID- 4338232 TI - Xanthomonas sinensis cell wall lipopolysaccharide. I. Isolation of 4,7-anhydro- and 4,8-anhydro-3-deoxy-octulosonic acid following acid hydrolysis of Xanthomonas sinensis lipopolysaccharide. PMID- 4338233 TI - 3-Polyprenyl-4-hydroxybenzoate synthesis in the inner membrane of mitochondria from p-hydroxybenzoate and isopentenylpyrophosphate. A demonstration of isoprenoid synthesis in rat liver mitochondria. PMID- 4338234 TI - Fluorescence studies of nucleotides and polynucleotides. 3. Diphosphopyridine nucleotide analogues which contain fluorescent purines. PMID- 4338236 TI - Mammalian -keto acid dehydrogenase complexes. VII. Resolution and reconstitution of the pig heart 2-oxoglutarate dehydrogenase complex. PMID- 4338235 TI - The mechanism of cell fusion. I. Energy requirements for virus-induced fusion of Ehrlich ascites tumor cells. PMID- 4338237 TI - Chemical modification of the inner mitochondrial membrane. PMID- 4338238 TI - Inhibition of the transport of several hexoses in mammalian cells by cytochalasin B. PMID- 4338239 TI - Changes in neuromuscular transmission in slow and fast skeletal muscles of the mouse after local injection of tetanus toxin. PMID- 4338240 TI - Electromyography as a diagnostic aid in lumbo-sacral nerve root irritation. PMID- 4338241 TI - Tumors of the liver in early infancy: hepatoblastoma. PMID- 4338242 TI - Cytomegalovirus in human milk. PMID- 4338243 TI - Ascending myelitis in association with herpes-simplex virus. PMID- 4338244 TI - Microtubules. PMID- 4338245 TI - Effect of glucagon on protein and RNA synthesis by spheroplasts of Escherichia coli. PMID- 4338246 TI - Ultrasonic evaluation of the kidneys. PMID- 4338247 TI - Results of small-field irradiation of apparent solitary metastasis from Wilms's tumor. PMID- 4338248 TI - Radiation effects on plasma electron-spin-resonance (ESR) spectra of cancer patients. PMID- 4338249 TI - Arteriography in diagnosis and management of acquired peripheral soft-tissue masses. PMID- 4338251 TI - The angiographic delineation of sellar and parasellar masses. PMID- 4338250 TI - Multiple cystic cavitary alveolar-cell carcinoma. PMID- 4338252 TI - Hybridization of Burkitt lymphoblastoid cells. AB - Burkitt lymphoblastoid cell lines have been fused to mouse and human cell lines with the use of inactivated Sendai virus. The heterokaryons have developed into somatic cell hybrids of both parental cell types. Chromosome analyses confirm that cells now growing in selective medium are hybrids. Initial observations of preparations of the hybrid cells reveal that 5'-iododeoxyuridine can induce continued synthesis of Epstein-Barr virus antigens by these hybrid cells. PMID- 4338253 TI - 5,6-Trans-25-hydroxycholecalciferol: vitamin D analog effective on intestine of anephric rats. AB - A new compound, 5,6-trans-25-hydroxycholecalciferol, has been synthesized and tested for its biological activity. Like 1,25-dihydroxycholecalciferol, it stimulates intestinal calcium transport in anephric rats, whereas 25 hydroxycholecalciferol does not. But this analog has little if any activity in stimulating mobilization of calcium from the bone of anephric rats. PMID- 4338254 TI - Viral RNA subunits in cells transformed by RNA tumor viruses. AB - Single-stranded 35S and 20S viral RNA species are synthesized in virus-producing mouse and rat cells transformed by the murine sarcoma virus. A transformed hamster cell line that does not produce virus synthesizes 35S, but not 20S viral RNA. PMID- 4338255 TI - Different serum insulin patterns in portal, hepatic and peripheral venous blood in two cases of insuloma. PMID- 4338256 TI - Experimental myocardial ischemia and infarction. Production of diffuse myocardial lesions in unanesthetized calves. PMID- 4338258 TI - Adrenergic and cholinergic nerve terminals in the rat parotid gland. Electron microscopic observations on permanganate-fixed glands. PMID- 4338257 TI - Role of isozymes in metabolic control. PMID- 4338259 TI - Inhibition of afferent transmission in cuneate nucleus during voluntary movement in the cat. PMID- 4338260 TI - Static and dynamic fusimotor activity during locomotor movements in the cat. PMID- 4338261 TI - Brain mechanisms in reaction time. PMID- 4338262 TI - Relationship of the discharges of cortical neurones to movement in free-to-move monkeys. PMID- 4338263 TI - The properties of the cerebello-pontine reverberating circuit. PMID- 4338264 TI - Mode of operation of the cerebellum in the dynamic loop control of movement. PMID- 4338265 TI - Neural design of the cerebellar motor control system. PMID- 4338266 TI - Pathogenesis of arterial hypertension after the constriction of the renal artery leaving the opposite kidney intact both in the anaesthetized and in the conscious dog. PMID- 4338267 TI - Elevation of alcohol dehydrogenase activity in the subclinically scorbutic guinea pig. PMID- 4338268 TI - Role of inhibition in the development of motor co-ordination in early childhood. PMID- 4338269 TI - Bovine herpes mammillitis in New York. PMID- 4338271 TI - Photooxidation of adenine and its nucleotides in the presence of riboflavin. IV. Photochemical reaction and photoproducts of NAD. PMID- 4338272 TI - Studies on cytochrome a. XX. Preparation and some properties of proteinase treated cytochrome a. PMID- 4338273 TI - Occurrence of different types of cytochrome b 5 -like hemoprotein in liver mitochondria and their intramitochondrial localization. PMID- 4338270 TI - Membrane-bound adenosine triphosphatase of Escherichia coli. I. Partial purification and properties. PMID- 4338274 TI - Problems in surgical management of renovascular hypertension. PMID- 4338275 TI - Cyclisation of -acylamino-acids in the presence of perchloric acid to give 5-oxo 2 -oxazolinium perchlorates. PMID- 4338276 TI - Rivanol precipitation technique for the detection of alpha-feto-protein. PMID- 4338277 TI - Rapid sequential liver imaging. PMID- 4338279 TI - Combined therapy in breast cancer. PMID- 4338280 TI - Chemodectoma of the lung. PMID- 4338281 TI - Malignant fibrous histiocytoma: an unusual inguinal tumor. PMID- 4338278 TI - Uptake of 75 Se-selenomethionine by hepatoma. PMID- 4338282 TI - Induction and threatment of Wilms tumor by transplantation of renal blastema in a new experimental model. PMID- 4338283 TI - Generalizations about hepatoma metastasis. PMID- 4338284 TI - Progress in the pathogenesis of adrenal hyperactivity. PMID- 4338285 TI - [Regulation of ACTH secretion and its anomaly]. PMID- 4338286 TI - [Synthetic ACTH: ACTH test]. PMID- 4338287 TI - [Synthetic ACTH: therapeutic application]. PMID- 4338289 TI - [Spectrum of antineoplastic agents in ascites hepatoma--hypothesis on application of the results of animal experiments to human cancer in screening of antineoplastic agents]. PMID- 4338288 TI - [Metabolism of vasoactive peptide in the lung]. PMID- 4338290 TI - Effect of papain on the carcinogenesis by P-dimethylaminoazobenzene (DAB). PMID- 4338291 TI - Guidelines for the use of steroids and ACTH. PMID- 4338292 TI - The Framingham study of coronary disease in women. PMID- 4338293 TI - Tryptophan and sleep in young adults. PMID- 4338294 TI - An ultradian biologic rhythm associated with perceptual deprivation and REM sleep. PMID- 4338296 TI - [Alpha-feto proteins in clinical medical practice]. PMID- 4338295 TI - The effect of dream (stage REM) deprivation on adaptation to stress. PMID- 4338297 TI - Retrobulbar neuritis as an early symptom of Guillain-Barre syndrome. Report of a case. PMID- 4338298 TI - Antigen-free medium for cultivation of Haemophilus influenzae, AFH-medium. PMID- 4338299 TI - Association of methicillin resistance to production of enterotoxin B and other factors in coagulase-positive and coagulase-negative staphylococci. PMID- 4338300 TI - Pieces in the puzzle. PMID- 4338301 TI - Action of drugs on sensory nerve endings. PMID- 4338302 TI - The lipids of bovine skin collagen. PMID- 4338303 TI - Fusobacterial infection: enhancement by cell free extracts of Bacteroides melaninogenicus possessing collagenolytic activity. PMID- 4338304 TI - Studies on the hypoglycaemic compound cyclopropanecarboxylic acid. Effects on gluconeogenesis in vitro. PMID- 4338305 TI - 1,4-Butanediol--a substrate for rat liver and horse liver alcohol dehydrogenases. PMID- 4338306 TI - Effects of amphetamine and fenfluramine on the net release of triglycerides of very low density lipoproteins by slices of rat liver. PMID- 4338307 TI - Effects of halothane and methoxyflurane on rat skeletal muscle mitochondria. PMID- 4338308 TI - Ethanol and the metabolic interrelations of carbohydrates and amino acids in brain preparations. PMID- 4338309 TI - Electron paramagnetic resonance studies of monomeric ferric Glycera hemoglobin. PMID- 4338310 TI - Entrapment of collagen in a polyacrylamide matrix and its application in the purification of animal collagenases. PMID- 4338311 TI - Thermostable glyceraldehyde-3-phosphate dehydrogenase from Bacillus stearothermophilus. I. Immunochemical studies. PMID- 4338312 TI - Cobalt erythrocuprein: preparation and properties. PMID- 4338313 TI - Bunyamwera virus replication in mosquitoes. PMID- 4338314 TI - Effect of guanidine on the growth of LSc poliovirus. PMID- 4338315 TI - Further studies on tumor-specific immunity induced by nontumorigenic mouse ascites tissue-culture cells. PMID- 4338316 TI - Comparison of the immunological properties of two canine adenoviruses. PMID- 4338317 TI - Alpha-ketoglutarate as an intermediate in glutamate metabolism by Peptococcus aerogenes. PMID- 4338318 TI - Purification and characterization of glutamic acid dehydrogenase and ketoglutaric acid reductase from Peptococcus aerogenes. PMID- 4338319 TI - [Effect of D-3 hypervitaminosis in female rats on the skeletal development of their fetuses]. PMID- 4338320 TI - [Primary tumors of the small intestine]. PMID- 4338321 TI - Glycopeptides of human immunoglobulins. 3. The use and preparation of specific glycosidases. PMID- 4338323 TI - An easy method for labelling polysaccharides with radioactive iodine. PMID- 4338322 TI - Angiotensin-antibody interaction. I. Induction of the antibody response. PMID- 4338324 TI - A comparison between materials used for liquid scintillation counting vials. PMID- 4338325 TI - Life cycle of diabetes in youth. 50th anniversary of the discovery of insulin (1921-1971). PMID- 4338326 TI - The ethics and sociology of peer review. PMID- 4338327 TI - Special report of the Medical Education and Research Committee of the American Medical Women's Association. Results of pilot survey of household help problems of women physicians in the United States. PMID- 4338328 TI - Differential renal effects of angiotensin after unilateral renal artery constriction. PMID- 4338329 TI - Potential over-diagnosis of pancreatic islet cell adenomas. PMID- 4338330 TI - Studies related to penicillins. 8. The rearrangement of penicillanic acid derivatives to 1,3-thiazines. PMID- 4338331 TI - The effect of interferon, interferon inducers or interferon induced virus resistance on subsequent interferon production. PMID- 4338332 TI - Characterization of interferon-associated proteins. PMID- 4338333 TI - A model for foot-and-mouth disease virus. PMID- 4338334 TI - Hybridization studies with subtypes and mutants of foot-and-mouth disease virus type O. PMID- 4338335 TI - Spread of pertussis by hospital staff. PMID- 4338336 TI - Parainfluenza pneumonia in adults. PMID- 4338337 TI - Glycogen mobilization after partial hepatectomy. Biochemical and ultrastructural studies. PMID- 4338338 TI - Transplantable luteoma of the mouse. An ultrastructural and biochemical study. PMID- 4338339 TI - Ultrastructure of lipid inclusions and dense bodies in the human sweat gland. PMID- 4338340 TI - [Determination of polymyxin with Escherichia coli]. PMID- 4338341 TI - Inhibition of rat liver mitochondria electron transport flow by aflatoxin B 1 . PMID- 4338342 TI - [Vitamin D metabolism and antiepileptics]. PMID- 4338343 TI - [Hypophysoadrenal effects of prolonged corticotherapy in small doses in asthmatic patients]. PMID- 4338345 TI - Tumor etiology and chromosome pattern. AB - Fibrosarcomas induced in Chinese hamsters and rats by Rous sarcomla virus and 7,12-dimethylbenz(a)anthracene are associated with nonrandom chromosome variation. Although histologically indistinguishable, the tumors induced by the virus or chemical in each host species are characterized by completely different karyotypic patterns. PMID- 4338344 TI - Interferon administered orally: protection of neonatal mice from lethal virus challenge. AB - Interferon was identified in the milk of mice injected with an interferon inducer. The kinetics of interferon appearance in serum and in milk were similar, but maximum concentrations in milk were 10 to 20 percent of those in serum. Interferon administered orally to neonatal mice was detected in their serums. Significantly more newborns survived an oral challenge with vesicular stomatitis virus when interferon had been induced in the lactating mothers. PMID- 4338346 TI - [Major hyperaldosteronisms secondary to unilateral nephropathy and surgically curable]. PMID- 4338347 TI - [Effects of lysine vasopressin on anterior pituitary secretions]. PMID- 4338348 TI - [Cushing's disease with spontaneous recovery lasting 30 years and then relapsing]. PMID- 4338350 TI - [Ocular determinations of Besnier-Boeck-Schaumann disease]. PMID- 4338349 TI - [Hormonotherapy of so-called solid tumors]. PMID- 4338351 TI - [2 observations of synovial sarcoma of the leg]. PMID- 4338352 TI - [Histochemistry of granular cell neurons in the hippocampus of the rat]. PMID- 4338353 TI - Sarcoma of the prostate gland. PMID- 4338354 TI - Adenoid cystic (cylindromatous) carcinoma of the uterine cervix: report of two cases. PMID- 4338355 TI - [Electric burns and neurologic manifestations]. PMID- 4338356 TI - Rapid test paper methods for hydrogen cyanide in the atmosphere. PMID- 4338357 TI - Environmental conditions in sanitary whiteware casting shops. PMID- 4338358 TI - Cytomegalovirus infection presenting as acute haemolytic anaemia in an infant. PMID- 4338359 TI - Effects of 1-(o-chlorophenyl)-1-(p-chloro-phenyl)-2,2-dichloroethane and puromycin on adrenocorticotropic hormone-induced steroidogenesis and on amino acid incorporation in slices of dog adrenal cortex. PMID- 4338360 TI - Biological activity of diazonium compounds. Studies on the mechanism of action of 4 (or 5)-diazoimidazole-5 (or 4)-carboxamide on 5-hydroxytryptamine release from rabbit platelets. II. Comparative studies with N-ethylmaleimide in vitro. PMID- 4338361 TI - Biochemical study of the anti-inflammatory activity of and -amyrin acetate. PMID- 4338362 TI - In vivo effects of carbon tetrachloride and chloroform on liver and kidney glucose-6-phosphatase in mice. PMID- 4338363 TI - The treatment of bronchial asthma. PMID- 4338364 TI - Binderless silica investments for dental casting. PMID- 4338366 TI - Extradural metastasis from a presumed carotid-body tumour producing paraplegia: a case report. PMID- 4338365 TI - Widespread extracranial metastases of glioblastoma multiforme. Report of case and clinicopathological review of cases in literature. PMID- 4338368 TI - Amotivational syndrome: the real management problem of schizophrenia. AB - Impaired insight is a prominent feature of the schizophrenic syndrome, and failure to take major tranquillizers by the oral route has resulted in many relapses. The introduction of the long-acting phenothiazine fluphenazine enanthate (Moditen Enanthate) has greatly facilitated the control of the florid symptoms of this disorder by transferring most of the responsibility for phenothiazine administration from the patients to the clinic or family physician. The educational maturing process, to enable these patients to cope with the challenges of adult life and the reality of their condition, can be handled more effectively through a therapeutic team approach, operating within the framework of a structured program, than by the traditional psychiatrist/patient relationship alone. PMID- 4338369 TI - [Compensatory hypertrophy in denervated muscle]. PMID- 4338367 TI - Glucagon: a "contaminant" comes of age. PMID- 4338370 TI - Inhibitory effect of N-phenyl-N'-aryl or alkylthiourea derivatives on poliovirus multiplication in cell cultures. PMID- 4338371 TI - Isolation of aortic cells of rabbits of various age. PMID- 4338372 TI - Morphology and biological properties of transplantable tumours induced by polyoma virus. PMID- 4338373 TI - Effect of adenosine 3',5'-monophosphate on melanin dispersion in the shore crab Carcinus maenas (L). PMID- 4338374 TI - Quantitative and experimental studies on the interrenal tissues of the upstream migrant stage of the river lamprey, Lampetra fluviatilis L. PMID- 4338375 TI - Hormonal effects on liver glycogen and blood sugar level in the iguanid lizard Dipsosaurus dorsalis. PMID- 4338377 TI - Clinical spectrum of male pseudohermaphroditism. PMID- 4338376 TI - Hepatocytic alterations induced by phenobarbitone--an ultrastructural study and histochemical assessment of glucose-6-phosphatase and lipid in the rat and rhesus monkey. PMID- 4338378 TI - Edemic nephropathy and cancer of the upper urinary tract urothelium in Yugoslavia. PMID- 4338379 TI - Stimulation of kanamycin phosphotransferase synthesis in Escherichia coli by 3',5'-cyclic AMP. PMID- 4338380 TI - Intracellular collagen in experimental arthritis in rats. PMID- 4338381 TI - [A malignant reticulosis with fatal cytomegalic inclusion disease--autopsy report of late Prof. Naotane Yoshinaga]. PMID- 4338383 TI - Congenital nephroma of infancy. PMID- 4338382 TI - Osteomalacia and spontaneous fractures in twins with congenital cytomegalic inclusion disease. PMID- 4338384 TI - Familial moniliasis, defective delayed hypersensitivity, and ACTH deficiency. PMID- 4338385 TI - Growth characteristics and factors influencing growth in Bartter's syndrome. PMID- 4338386 TI - The myopathic variety of arthrogryposis multiplex congenita: a disorder with autosomal recessive inheritance. PMID- 4338388 TI - A radical cation produced in a -irradiated single crystal of DL-methionine as studied by electron spin resonance and optical absorption spectroscopy. PMID- 4338387 TI - Syndrome of inappropriate secretion of antidiuretic hormone produced by vincristine toxicity (with bioassay of ADH level). PMID- 4338389 TI - Ultrathin frozen sections of yeast cells. PMID- 4338390 TI - Developmental pathway of granular and beaded nuclear bodies from nucleoli. PMID- 4338391 TI - The treatment of multiple sclerosis. PMID- 4338392 TI - [Epilepsy in childhood]. PMID- 4338393 TI - [Electroencephalography in the diagnosis of brain neoplasms. Case reports]. PMID- 4338394 TI - Inhibition by papaverine and eupaverin of 3', 5'-cyclic AMP phosphodiesterase from rabbit skeletal muscle. PMID- 4338395 TI - Decreased toxicity of d-tubocurarine after pretreatment with drugs elevating the intracellular level of c-AMP in mice. PMID- 4338396 TI - Activation and inhibition of lipolysis in isolated fat cells by various inhibitors of cyclic AMP phosphodiesterase. PMID- 4338397 TI - [Alcohol dehydrogenase activity of the gastric mucosa following various ethanolic treatments in rats]. PMID- 4338398 TI - Effects of nicotinic acid and some of its homologues on lipolysis, adenyl cyclase, phosphodiesterase and cyclic AMP accumulation in isolated fat cells. PMID- 4338399 TI - Comparison of the effects of cyclazocine and imipramine on the circadian sleep waking cycle of the cat. PMID- 4338400 TI - [The lumbo-sacral radicular irritation syndrome as a psychosomatic problem]. PMID- 4338401 TI - Effects of morphine on sleep in the cat. PMID- 4338402 TI - The ultrastructure of the liver in human symptomatic porphyria. A preliminary communication. PMID- 4338404 TI - [Injury of the pancreas. Value of selective arteriography]. PMID- 4338403 TI - Primary carcinoma of the liver (hepatoma) in Rhodesia: a clinical study. PMID- 4338405 TI - [Accidental hypothermia in toxic comas (apropos of 36 cases)]. PMID- 4338406 TI - [Lyell's syndrome or acute epidermal necrosis (apropos of 2 cases)]. PMID- 4338407 TI - [Botulism]. PMID- 4338409 TI - [Fetal death in utero due to Moraxella Lwoffi placental infection]. PMID- 4338408 TI - [Acute heart failure after a moderate dose of rubidomycin]. PMID- 4338410 TI - Summary of recent abstracts. II. Amoebiasis and intestinal protozoal infections. PMID- 4338412 TI - Continuous prolonged intrahepatic infusion of 5-fluorouracil in the treatment of hepatoma in Ibadan. PMID- 4338411 TI - [Complications following lymphography]. PMID- 4338413 TI - Monkey-pox in a four-year old girl: case report. PMID- 4338414 TI - Methyl xantines in the inhibition of platelet aggregation. PMID- 4338415 TI - Inhibition of platelet aggregation by chemicals and drugs. PMID- 4338417 TI - Discussion paper: membrane proteins in Neurospora and yeast. PMID- 4338416 TI - [Preeminence of intravenous urography in the detection of surgically curable renovascular hypertension]. PMID- 4338418 TI - Membrane proteins: a perspective. PMID- 4338419 TI - The flexibility gradient in biological membranes. PMID- 4338420 TI - Monolayer studies of 3-nitroxide cholestane. PMID- 4338421 TI - Structure of human serum lipoproteins. PMID- 4338422 TI - Immune damage to a lipid model membrane. PMID- 4338423 TI - Molecular architecture of biological membranes. PMID- 4338424 TI - Posterior interosseus branch of the radial nerve: conduction velocities. PMID- 4338425 TI - [Research on the causes of death among calves on the sub-Sudan savannahs of the northern Ivory Coast]. PMID- 4338426 TI - Increased prothrombin time and metabolic changes with high serum aluminum levels following long-term exposure to Bayer-process alumina. AB - Serum aluminum levels twice to three times those in controls were found in 30 of 36 workers in a factory in an atmosphere of alumina dust. Inorganic phosphate and total alkaline phosphatase levels were within normal range, with no clinical evidence of phosphate depletion syndrome. Serum intestinal alkaline phosphatase, acid phosphatase and adenosine triphosphate levels were significantly reduced in the group with high levels of aluminum. The finding that the mean prothrombin time was significantly prolonged is of particular interest with respect to beneficial antithrombogenic effect. PMID- 4338427 TI - Projections of the cochlea to the dorsal cochlear nucleus in the cat. PMID- 4338428 TI - Esophago-pleural fistulae secondary to perforated esophageal ulcer. PMID- 4338429 TI - Male pattern alopecia and/or androgenic hirsutism in females. 3. Definition and etiology. PMID- 4338430 TI - Increasing consumer participation in professional goal setting: contraception and therapeutic abortion. PMID- 4338431 TI - The separation of N- -trifluoroacetyl-DL-lysine from potassium trifluoroactate by liquid chromatography. PMID- 4338433 TI - A rapid low voltage ionophoretic separation of 3',5'-cyclic adenosine monophosphate. PMID- 4338432 TI - Direct fluorometric microdetermination of phospholipids on thin-layer chromatograms. PMID- 4338434 TI - Radioautographic study on activities of multinucleated cells induced by Sendai virus. PMID- 4338435 TI - Multiple chemodectomas: concurrent left carotid body tumor and right glomus jugulare tumor. PMID- 4338436 TI - Ultrastructural development of stalk-producing cells in dictyostelium discoideum, a cellular slime mould. PMID- 4338437 TI - Immunochemical studies on chlamydial group antigen (presence of a 2-keto-3 deoxycarbohydrate as immunodominant group). PMID- 4338438 TI - Rapid micro-radioimmunoassay for the measurement of antiviral antibody. PMID- 4338440 TI - Enzyme histochemistry of the rat hypothalamus during early development. PMID- 4338439 TI - The incorporation of labelled acetate into cerebroside and other lipids of the developing mouse brain. PMID- 4338441 TI - Effect of probenecid on levels of cyclic AMP in human cerebrospinal fluid. PMID- 4338442 TI - Activation of insect nerve cord phosphorylase by octopamine and adenosine 3',5' monophosphate. PMID- 4338443 TI - Neurogenic muscle atrophy in myasthenia gravis. AB - Two cases of severe myasthenia gravis are described, with histological findings. Both cases showed severe neurogenic atrophy of the muscles of the tongue, with fatty pseudohypertrophy and a remarkable proliferation of terminal nerve fibres. Similar, but less severe, changes were present in other bulbar muscles. The findings are in keeping with the view that functional interruption at the neuromuscular junctions results first in failure to transmit the contractile impulse, and at a later stage in denervation atrophy. Terminal proliferation of axons is regarded as an attempt, on the part of motor fibres, to compensate for the breakdown of normal neuromuscular interaction. PMID- 4338444 TI - Neuropathy after alcohol withdrawal. AB - Three probable cases of neuropathy in alcoholics are described. They are very atypical for three reasons. First, each developed an acute asymmetrical neuropathy for the first time well after ceasing to drink, and after routine saturation with the vitamin B group. Secondly, none had previously suffered from neuropathy while still drinking. If this puzzling reversal of the usual order of clinical events has been noticed before, no record has been found in the literature. Further study by psychiatrists treating alcoholics aided by their neurological colleagues is suggested. PMID- 4338445 TI - Electrophysiological studies in alcoholism. AB - Using a range of electrophysiological techniques, it has been possible to demonstrate impaired function in smaller calibre motor fibres and in distal large cutaneous sensory nerve fibres in both alcoholic patients without neuropathy and in those alcoholics with clinical manifestations of peripheral nerve disease. Evidence of more proximal involvement of Ia sensory fibres was obtained, but in the majority of our patients, large motor fibres functioned normally. The nature of the underlying pathological process is discussed. PMID- 4338446 TI - Effect of magnesium on nerve conduction velocity during regular dialysis treatment. AB - Serial nerve conduction velocities in the peroneal and ulnar nerves have been measured in 10 patients on regular dialysis treatment over a three year period. Each patient alternated between phases on dialysis with magnesium-containing dialysate (1.5-1.7 m-equiv/l.) and phases on 'magnesium-free' dialysate (0.2 m equiv/l.). Plasma magnesium concentrations were high both pre- and post-dialysis during magnesium-containing dialysis, and normal to low on magnesium-free dialysis. All patients had defects in nerve conduction, mainly asymptomatic. Increases in nerve conduction velocity coincided with magnesium-free dialysis, and decreases occurred when the patients reverted to magnesium-containing dialysate. The significance of the correlation by the sign test was P<0.0005. It is concluded that extracellular magnesium levels can influence the rate of nerve conduction in vivo. PMID- 4338447 TI - A preclinical case of late adult metachromatic leukodystrophy? Manifestation only with lipid abnormalities in urine, enzyme deficiency and decrease of nerve conduction velocity. AB - In a clinically unremarkable 39 year old sister of a patient afflicted with late adult metachromatic leukodystrophy, metachromatic deposits in the epithelial cells of the urine sediment, a high sulphatide excretion in the urine, and a deficiency of arylsulphatase A in urine and leucocytes were found. The motor nerve conduction velocity of the peripheral nerves in upper and lower extremities was distinctly decreased. Cerebral disturbances were not evident. It is surmised that this patient is a case of late adult metachromatic leukodystrophy in an early stage of the disease without obvious clinical signs. The peripheral neuropathy found by neurophysiological examination is interpreted as an early symptom of the disease. PMID- 4338448 TI - Multiple sclerosis associated with defects in neuromuscular transmission. AB - Three patients with multiple sclerosis characterized by exacerbations and remissions of nervous system signs and symptoms disseminated in time and space also had the kind of easy fatiguability seen in myasthenia gravis. In each case abnormal decrements to repetitive stimulation were electromyographically demonstrated and treatment with ephedrine or anticholinesterase drugs increased the patient's functional capacity while improving the electromyographic abnormality. The suggestion is that these patients represent an overlap syndrome, analogous to the overlap syndrome existing between systemic lupus erythematosus and rheumatoid arthritis where clinical and laboratory features of two diseases coexist in the same patient at the same time. Presumably some patients with multiple sclerosis have deficient production of acetylcholine, just like patients with myasthenia, and treatment with agents useful in myasthenia is able partially to correct the symptoms caused by the deficiency. The cases illustrate how in neurology greater attention to the more immediate cause of clinical symptoms, in the absence of a known aetiology, may result in benefit to the patients. PMID- 4338449 TI - Inactivation of yeast alcohol dehydrogenase by dehydroascorbic acid and D arabinosone. PMID- 4338451 TI - Effect of riboflavin tetrabutyrate on degradation of -lipoprotein by fatty acid peroxide. PMID- 4338450 TI - Identification of riboflavinyl -D-glucoside in cat liver. PMID- 4338452 TI - Eczema herpeticum: presenting as hand, foot and mouth syndrome. PMID- 4338453 TI - [ -Fetoprotein in liver diseases and extrahepatic tumors. Case review]. PMID- 4338454 TI - [Lupus type inclusions in the skin. Diagnostic value]. PMID- 4338455 TI - [Primary carcinoma of the liver in adults. Surgical treatment by partial hepatectomy]. PMID- 4338456 TI - [Tubular inclusions. Discovery in endothelial cells of a subcutaneous myxoma]. PMID- 4338457 TI - [Infantile hepatology. Bilirubin metabolism. Physiologic jaundice. Nuclear jaundice]. PMID- 4338458 TI - The small-for-date infant. I. Later growth patterns. PMID- 4338459 TI - Symposium: behavior modification by drugs. I. Pharmacology of the amphetamines. PMID- 4338460 TI - Hypoglycemia and leukemia. PMID- 4338461 TI - Calcium transient in presynaptic terminal of squid giant synapse: detection with aequorin. AB - Microinjection of aequorin, a bioluminescent protein sensitive tocalcium, into the presynaptic terminal of the squid giant synapse demnonstrated an increase in intracellular calcium ion concentration during repetitive synaptic transmission. Although no light flashes synchronous with individual presynaptic : tion potentials were detected, the results are considered consistent with the hypothesis that entry of calcium into the presynaptic terminal triggers release of e synaptic transmitter substance. PMID- 4338462 TI - 1,25-dihydroxycholecalciferol: metabolite of vitamin D3 active on bone in anephric rats. AB - Nephrectomy prevents completely the bone calcium mobilization response to 25 hydroxycholecalciferol. In contrast it does not prevent this response to 1,25 dihydroxycholecalciferol. Because it is known that the kidney is the site of 1,25 dihydroxycholecalciferol formation, these results provide evidence that 1,25 dihydroxycholecalciferol or a further metabolite thereof and not 25 hydroxycholecalciferol is the metabolically active form of vitamin D(3) responsible for bone calcium mobilization. PMID- 4338463 TI - [Inductors and repressors of the genetic and protein-synthesizing systems of mitochondria]. PMID- 4338464 TI - [Determination of N-acetylneuraminic acid in proteolytic fission products in tumor cell membranes]. PMID- 4338465 TI - [An early case of scaphocephaly from southern Hessen]. PMID- 4338466 TI - [Relationship between osmotic reactivity of the thirst mechanism and the angiotensin and aldosterone blood levels in dogs]. PMID- 4338468 TI - Lung cancer in young adults. PMID- 4338467 TI - [Optimal dehydration of the corneal lamellae for lamellar corneal grafts]. PMID- 4338469 TI - The value of mediastinoscopy in assessing operability in carcinoma of the lung. PMID- 4338470 TI - [Experiences in the breeding of work animals in the sub-Sudan savannahs of the northern Ivory Coast]. PMID- 4338472 TI - Enhancement of cardiovascular effects of glucagon by aminophylline. PMID- 4338471 TI - A comparison of the cardiovascular actions of indoramin, propranolol, lignocaine, and quinidine. PMID- 4338473 TI - Variable effect of angiotensin infusion on left ventricular function. PMID- 4338474 TI - [Endocytosis of the thyroid gland]. PMID- 4338475 TI - Epicillin in the treatment of shigellosis and salmonellosis. PMID- 4338476 TI - Inhibition of norepinephrine-, angiotensin II-, and vasopressin-induced contractions of smooth muscle by acyl derivatives of adenosine-3',5' monophosphate. PMID- 4338478 TI - Effects of ketamine (CI 581) on cell responses to cutaneous stimulations in laminae IV and V in the cat's dorsal horn. PMID- 4338477 TI - A potent competitive antagonist of angiotensin II. PMID- 4338479 TI - Effects of ADH and dibutyryl cyclic amp on submaxillary secretion in the dog. PMID- 4338480 TI - Extramammary Paget's disease of the anus. PMID- 4338481 TI - Enrichment of bis-(monoacylglyceryl) phosphate in lysosomes from rat liver. PMID- 4338482 TI - Competing methyltransferase systems. PMID- 4338483 TI - The binding of cyclic adenosine monophosphate receptor to deoxyribonucleic acid. PMID- 4338484 TI - Allosteric changes of p-nitrophenylphosphatase from rat erythrocytes in fat deficiency. PMID- 4338485 TI - Histidine regulation in salmonella typhimurium. XIV. Interaction of the histidyl transfer ribonucleic acid synthetase with histidine transfer ribonucleic acid. PMID- 4338486 TI - The mechanism of action of ethanolamine ammonia lyase, a B 12 -dependent enzyme. X. A study of the reaction by electron spin resonance spectrometry. PMID- 4338487 TI - In vitro metabolism of 25-hydroxycholecalciferol by chick intestinal and renal cell preparations. Identification of a metabolic product as 1,25 dihydroxycholecalciferol and delineation of its metabolic fate in intestinal cells. PMID- 4338488 TI - The in vitro metabolism of 25-hydroxycholecalciferol to 1,25 dihydroxycholecalciferol by chick renal tubules. Effect of actinomycin D, puromycin, calcium, and parathyroid hormone. PMID- 4338490 TI - Hodgkin's disease, failing immunity and varicella-zoster. PMID- 4338489 TI - Protocatechuate 3,4-dioxygenase. II. Electron spin resonance and spectral studies on interaction of substrates and enzyme. PMID- 4338491 TI - Primary carcinoma of the liver in Uganda. PMID- 4338492 TI - Cellular events in the adrenal cortex following ACTH deprivation. PMID- 4338493 TI - Studies on tubular degeneration of the adrenal cortex. PMID- 4338494 TI - Foetal-type antigen on the surface of hepatoma cells--evidence from cell electrophoresis. PMID- 4338495 TI - Morphological transformation of human embryo fibroblasts in vitro by EB virus. PMID- 4338497 TI - Comparative stabilities of ampicillin and hetacillin in aqueous solution. PMID- 4338496 TI - Influence of solvents on adsorption of ionic surfactants on highly dispersed silicas. PMID- 4338498 TI - Ultrastructural and cytochemical changes in cultured human lung cells. PMID- 4338499 TI - Intranuclear filamentous inclusions in neurons of the rabbit hypothalamus. PMID- 4338500 TI - Insect neurometamorphosis. V. Fine structure of axons and neuroglia in the transforming interganglionic connectives of Galleria mellonella (L.) (Lepid optera). PMID- 4338501 TI - Coal and coal mine drainage. PMID- 4338502 TI - [The spinal cord, peripheral nerves and kinetic ataxia]. PMID- 4338503 TI - [Ataxia associated with sensory disturbances]. PMID- 4338504 TI - [Ataxia associated with malignant tumors]. PMID- 4338505 TI - [Von Recklinghausen's disease and glioma of the brain--appendix: malignant neurinoma]. PMID- 4338506 TI - [Case of lung cancer in coal miner's pneumoconiosis]. PMID- 4338507 TI - [Autopsy case of polymyeloradiculitis showing small inclusion-like bodies in the hepatic cell nuclei]. PMID- 4338508 TI - Incorporation of 32 P into phospholipids of the adrenal medulla during and after stimulation by secretogogues. PMID- 4338509 TI - Effect of noradrenaline on non-adrenergic inhibitory response of guinea-pig taenia coli. PMID- 4338510 TI - Effect of N 6 , 2'-O-dibutyryl 3'5'-cyclic adenosine monophosphate, 3', 5', cyclic adenosine monophosphate and adenosine triphosphate on acetylcholine output from cholinergic nerves in guinea pig ileum. PMID- 4338512 TI - [Effect of sodium salicylate on some viruses]. PMID- 4338511 TI - [Production of RS virus antigens during growth in HEp-2 culture. I. Fluorescent antibody assay]. PMID- 4338513 TI - [Studies on the effect of pyrazine derivatives on some DNA and RNA viruses. I. Effect of pyrazine amidrazone and products of its condensation with aldehydes and ketones on adsorption and replication of polio, WEE and vaccinia viruses]. PMID- 4338514 TI - [Clinical significance of alpha-fetoprotein--with special reference to surgical cases of liver cell carcinoma]. PMID- 4338516 TI - [Autopsy case of multiple myeloma associated with dermatomyositis, polyneuropathy and diabetes mellitus]. PMID- 4338515 TI - [Autopsy case of primary hepatoma with Budd-Chiari syndrome caused by cancerous embolism]. PMID- 4338517 TI - Proposed models for angiotensin II in aqueous solution and conclusions about receptor topography. PMID- 4338518 TI - Specific labelling of virus proteins by quantitative reaction of cysteine residues with 35 S-sulphite. PMID- 4338519 TI - Expression of polyoma-induced transplantation antigen in hybrid cell lines. PMID- 4338520 TI - Intracellular free Ca 2+ and membrane properties of motoneurones. PMID- 4338521 TI - Occurrence of Epstein-Barr virus genomes in human lymphoblastoid cell lines. PMID- 4338522 TI - Unlearned and learned effects of intrahypothalamic cyclic AMP injection on feeding. PMID- 4338523 TI - Mechanism of nerve block. PMID- 4338524 TI - [A patient with behavior disorders]. PMID- 4338525 TI - [Demonstration of varicella-zoster virus in the trigeminal nerve ganglion]. PMID- 4338526 TI - [Continuous assay of blood sugar during surgery of Langerhans adenoma]. PMID- 4338528 TI - Relationship between left ventricular and aortic dP-dt (max). PMID- 4338527 TI - The differential diagnosis of sciatica. PMID- 4338529 TI - [Central facial paralysis caused by a unilateral subcortical lesion]. PMID- 4338530 TI - [Gamma-encephalography in subtentorial arterio-venous aneurysms]. PMID- 4338532 TI - [Significance of coordinated therapy in outpatient and inpatient clinics for the length of preoperative stay and length of work disability]. PMID- 4338531 TI - Total haemolytic complement after liver transplantation and in liver disease. PMID- 4338533 TI - Chitinase activity and substrate specificity of three bacteriolytic endo-beta-N endo-beta-N-acetylglucosaminidase. PMID- 4338535 TI - [Removable partial prostheses in children]. PMID- 4338534 TI - Ethnic distribution of cytologically diagnosed herpes simplex genital infections in a cervical cancer screening program. PMID- 4338536 TI - [Anaerobic sepsis following abortion]. PMID- 4338537 TI - [Respiratory viral infections in pregnant women and neonates]. PMID- 4338538 TI - [The course of labor and the puerperal period in acute respiratory viral infections]. PMID- 4338539 TI - Epstein-Barr virus (herpes-type virus) antibodies in connective tissue diseases. PMID- 4338541 TI - Pathology of testis tumours. PMID- 4338540 TI - Cortisol production by testicular tumors in adrenogenital syndrome. PMID- 4338542 TI - The place of radiotherapy in testicular tumours. PMID- 4338543 TI - Strychnine-resistant mutual inhibition of Renshaw cells. PMID- 4338544 TI - The early phase of adaptation in repetitive impulse discharges of cat spinal motoneurones. PMID- 4338545 TI - Selective suppression of REM sleep by probenecid. PMID- 4338546 TI - [Effect of age and preceding elevated adrenal-cortex activity in calves on the production of 17-hydroxycorticosteroids in vitro]. PMID- 4338547 TI - [A case of congenital epulis]. PMID- 4338550 TI - [Developmental disorders in cytomegaly]. PMID- 4338551 TI - Views on the current role of psychiatric hospitalization. PMID- 4338548 TI - The role of the sympathetic nervous system in hypoglycaemia-stimulated gastric secretion. AB - The gastric secretory response to insulin is mediated predominantly by the vagus. The associated hypoglycaemia stress response is mediated by the sympathetic nervous system. Inhibition of the sympathetic response by simultaneous alpha and beta receptor blockade was studied in five healthy young adults. No appreciable modification of gastric secretory output resulted. PMID- 4338549 TI - Radioimmunoassay of carcinoembryonic antigen in serum of normal subjects and patients with colonic carcinoma. AB - Sera from 14 normal subjects and 43 patients with colonic carcinoma were evaluated for the presence of carcinoembryonic antigen (CEA). Inhibiting material which behaved in the assay in a similar manner to CEA was found in normal serum at concentrations below 2.8 ng/ml. Its nature has not so far been established. Thirty-eight of the 43 patients with colonic carcinoma showed levels of serum CEA in excess of 2.8 ng/ml. The concentration of CEA in serum was correlated with the extent of the disease as classified by a staging procedure similar to that of Dukes (1932). Examination of a small number of specimens of colonic carcinoma and normal colonic mucosa suggested that the concentration of CEA in different adenocarcinomata may vary, and that traces of cross-reacting material may be found in some normal mucosae. PMID- 4338552 TI - Anti-cholesterol activity in antisera against human serum lipoproteins. PMID- 4338553 TI - Lateral diffusion in spin-labeled phosphatidylcholine multilayers. PMID- 4338554 TI - Studies of the crystalline-liquid crystalline phase transition of lipid model membranes. I. Use of spin labels and optical probes as indicators of the phase transition. PMID- 4338556 TI - Studies of the crystalline-liquid crystalline phase transition of lipid model membranes. 3. Structure of a steroid-lecithin system below and above the lipid phase transition. PMID- 4338555 TI - Studies of the crystalline-liquid crystalline phase transition of lipid model membranes. II. Analysis of electron spin resonance spectra of steroid labels incorporated into lipid membranes. PMID- 4338557 TI - Characterization of a d iron system. Tetraphenylporphineiron (I) anion. PMID- 4338558 TI - Failure sequence in solid-phase peptide synthesis due to the presence of an N alkylamino acid. PMID- 4338559 TI - Effect of vaccination time on morbidity, mortality, and weight gains of feeder calves. PMID- 4338560 TI - Effect of ACTH and selected glucocorticoids on circulating blood cells in horses. PMID- 4338561 TI - Effect of estrogens on tissue plasminogen activators and their inhibitors. PMID- 4338562 TI - Mitochondrial respiratory chain of carotid body and chemoreceptor response to changes in oxygen tension. PMID- 4338563 TI - Tectal and tegmental influences on cat forelimb and hindlimb motoneurons. PMID- 4338564 TI - Intracellular redox changes preceding onset of epileptiform activity in intact cat hippocampus. PMID- 4338565 TI - A chloride-dependent inhibitory postsynaptic potential in cat trochlear motoneurons. PMID- 4338566 TI - Relay of receptive-field properties in dorsal lateral geniculate nucleus of the cat. PMID- 4338567 TI - Adrenalinogenic secretion of nonchromaffin paraganglioma. PMID- 4338568 TI - Juvenile nasopharyngeal angiofibroma. PMID- 4338569 TI - Mammary noduligenic activity of the sperm from various high mammary tumor strain mice in histocompatible recipients of different ages. PMID- 4338570 TI - [Breast carcinoma in young women]. PMID- 4338571 TI - [Effect of 3'- 5' -cyclic AMP on the blood sugar level in rabbits]. PMID- 4338572 TI - [Appearance of peripheral nerve lesions]. PMID- 4338573 TI - After-care and rehabilitation following coronary thrombosis. PMID- 4338574 TI - Lateral pharyngeal abscess secondary to herpetic gingivostomatitis. Report of a case. PMID- 4338575 TI - Congenital gingival granular-cell myoblastoma. PMID- 4338576 TI - [Relation of smallpox vaccination complications with infections caused by respiratory viruses]. PMID- 4338577 TI - [Clinical and morphological signs of adenovirus and mixed influenza-adenovirus infections with lethal outcomes in children]. PMID- 4338578 TI - [Pathomorphology of the respiratory organs in RS-virus infections (sectional and experimental data)]. PMID- 4338579 TI - [Effect of 6-azauridine on the reproduction of adenoviruses and effectiveness of its use for adenovirus infections in children]. PMID- 4338580 TI - [Clinico-virological study of neuroinfectious diseases in children]. PMID- 4338581 TI - Catabolite repression of bacterial bioluminescence: functional implications. AB - The synthesis of the bioluminescent system of the marine luminous bacterium Photobacterium fischeri (strain MAV) is subject to both transient and catabolite repression by glucose, and this repression can be reversed by adenosine 3':5' cyclic monophosphate. Catabolite repression is a mechanism that characteristically controls the synthesis of inducible enzymes involved in energy metabolism. The fact that luciferase synthesis is subject to this control suggests that whatever its role(s) may be, it cannot be considered a nonfunctional or vestigial enzyme system as previously hypothesized, and may actually have some more direct role in metabolic processes. PMID- 4338582 TI - Detection and isolation of the repressor protein for the tryptophan operon of Escherichia coli. AB - DNA from a transducing bacteriophage carrying a fusion of the tryptophan and lactose operons of E. coli (lambdadtrp-lac) has been used to direct cell-free synthesis of beta-galactosidase (EC 3.2.1.23). Whereas normal lac operon (lambdadlac) DNA requires adenosine-3':5'-cyclic monophosphate (cAMP) for beta galactosidase synthesis, trp-lac DNA is unaffected by cAMP. This difference in cAMP dependence verifies the presence of a cAMP-requiring promoter in the lac operon that has been removed from the trp-lac DNA. Synthesis with trp-lac DNA is controlled by the protein product of the tryptophan repressor gene (trpR). Synthesis in extracts of trpR(-) (repressor-negative) cells is progressively reduced by increased additions of extract from trpR(+) cells. No trpR(-) product repression is seen when beta-galactosidase synthesis is programmed by normal lac DNA. This highly sensitive and specific assay has facilitated quantitation and partial purification of the trp repressor. PMID- 4338583 TI - Biologically active catecholamines covalentyly bound to glass beads. AB - Catecholamines bound covalently to glass beads have been found to have biological activity in several systems. Experimental evidence has been found that immobilized epinephrine and isoproterenol accelerate the heart rate in dogs, chick embryo, and chick heart cells grown in culture, whereas immobilized propranolol results in a decrease in heart rate. Isoproterenol bound to glass beads has also been shown to markedly increase the level of adenosine 3':5' cyclic monophosphoric acid in glial cells. The effects of the immobilized catecholamines are of longer duration than when the compounds are administered in solution. The present data indicate that the compounds are exerting their action when bound to the beads. PMID- 4338584 TI - The 3'-terminal nucleosides of the high molecular weight RNA of avian myeloblastosis virus. AB - The RNA isolated from avian myeloblastosis virus was fractionated by sucrose density gradient centrifugation. The 3'-OH terminal nucleosides of various fractions were determined by periodate oxidation followed by tritiated borohydride reduction. The 60-70S fraction and the 35S RNA derived from it by heating both have adenosine as the major terminal nucleoside, with cytidine as the next most frequent terminal. Control samples of tRNA(met) (f. coli) and 28S ribosomal RNA from mouse ascites tumor cells gave the expected terminal residues and molecular weights. PMID- 4338585 TI - Effect of dibutyryladenosine 3':5'-cyclic monophosphate on growth and differentiation in Caulobacter crescentus. AB - Caulobacter crescentus goes through a series of morphological changes during its life cycle, including the coincident expression of synthesis of flagella, pili, and receptor sites for DNA bacteriophage. Upon transfer of a mixed population of cells to medium containing lactose as the sole carbon source, these changes were blocked for about 20 hr until beta-galactosidase activity became apparent. The addition of dibutyryl cyclic AMP to the blocked cultures brought about the resumption of cell differentiation, growth, and the appearance of beta galactosidase activity within 1 hr. Unlike Escherichia coli, the intracellular and extracellular concentrations of cyclic AMP in C. crescentus did not vary under several growth conditions, including catabolite repression. It would appear, therefore, that although there is an effect of cyclic AMP on the induction of beta-galactosidase and differentiation in C. crescentus, regulation of these processes occurs without consistent changes in the cellular level of this nucleotide. PMID- 4338586 TI - Accumulation of adenosine 3':5'-cyclic monophosphate in clonal glial cells: labeling of intracellular adenine nucleotides with radioactive adenine. AB - The accumulation of endogenous adenosine 3':5'-cyclic phosphate (cAMP) and of [(14)C]cAMP, derived from nucleotides labeled by prior incubation of cells with [(14)C]adenine, has been investigated in four glial cell lines from rats. The following results are similar to data reported for brain slices: (i) rat glial cells contain a system that readily incorporates [(14)C]adenine into nucleotides that serve as precursors for cAMP. (ii) norepinephrine stimulates accumulation of both [(14)C]cAMP and endogenous cAMP, and (iii) the phosphodiesterase inhibitors, papaverine and isobutylmethylxanthine, are effective in enhancing the stimulatory effect of norepinephrine. In contrast to results reported for brain slices, histamine, veratridine, and adenosine, the purine either alone or with a biogenic amine, do not cause an enhanced accumulation of cAMP in rat glial cells, and repetitive accumulations of cAMP can be elicited during a series of restimulations of the cells with norepinephrine. The magnitude of the accumulation of cAMP elicited by the catecholamine decreases markedly by the fifth restimulation in the absence of, but only slightly in the presence of, papaverine. In glial cells, a large portion of the [(14)C]adenine is incorporated into intracellular compounds that do not serve as precursors of [(14)C]cAMP. PMID- 4338587 TI - Inhibition of sterol biosynthesis by bacitracin. AB - Bacitracin is an inhibitor of the biosynthesis of squalene and sterols from mevalonic acid, C(5)-isopentenyl pyrophosphate, or C(15)-farnesyl pyrophosphate catalyzed by preparations from rat liver. The antibiotic is active at extremely low ratios of antibiotic to substrate. The mechanism of inhibition appears to be the formation of a complex between bacitracin, divalent cation, and C(15) farnesyl pyrophosphate and other isoprenyl pyrophosphates. It is similar to the formation of the complex with C(55)-isopropenyl pyrophosphate in microbial systems. The toxicity of bacitracin for animal cells could be due in part to the formation of these complexes. PMID- 4338588 TI - Activation of the viral genome in Simian Virus 40-transformed nonpermissive cells by permissive cell extracts. AB - Simian virus 40-transformed nonpermissive cells in which neither infectious viral DNA nor virions had previously been detected reproducibly yield low levels of infectious simian virus-40 DNA after treatment with extracts of normal permissive cells. Virions were obtained in one out of 37 experiments. Activation of the viral genome is detected only with normal permissive cell extracts and only in simian virus 40-transformed cell lines that are rescuable by heterokaryon formation or by treatment with chemicals. The activating factor(s) is insensitive to deoxyribonuclease and ribonuclease, but is sensitive to heat at 56 degrees and to proteolytic enzymes. PMID- 4338589 TI - 3-Cyclic amine derivatives of rifamycin: strong inhibitors of the DNA polymerase activity of RNA tumor viruses. AB - Derivatives of rifamycin-SV with substituted cyclic-amine side chains in position 3 of the ansa ring are strong inhibitors of RNA-directed DNA and DNA-directed DNA polymerase activity of RNA tumor viruses of murine, feline, and avian origin. Among 37 3-amine derivatives of rifamycin-SV that were tested, 29 3-cyclic amine derivatives were good inhibitors of the viral polymerases. Especially active were 3-piperidyl derivatives of rifamycin-SV with cyclohexyl and cyclohexylalkyl substituents. Derivatives that were effective against the viral polymerase also blocked cell transformation by the murine sarcoma virus. A DNA-directed DNA polymerase preparation from human KB cells was less sensitive to inhibition by these derivatives than the virion polymerase. PMID- 4338590 TI - Increased efficiency of exogenous messenger RNA translation in a Krebs ascites cell lysate. AB - Addition of a 0.5 M KCl wash fraction from rabbit reticulocyte ribosomes causes a 3- to 10-fold increase in the extent of translation of natural mRNAs by Krebs cell lysates. In the presence of the wash fraction, 1 pmol of rabbit or mouse 10S RNA directs the incorporation of 80 pmol of leucine into rabbit globin. The addition of human 10S RNA results in the synthesis of equal amounts of human alpha and beta chains, identified by column chromatography. The stimulation by the wash fraction is almost completely dependent on added mammalian tRNA. In contrast to the wash fraction from rabbit reticulocytes, the wash fraction isolated from Krebs-cell ribosomes is inhibitory to both endogenous and exogenous mRNA translation. The stimulation by the wash fraction from rabbit ribosomes is not specific for globin mRNAs, but also increases endogenous, phage Qbeta, and viral RNA-directed protein synthesis. PMID- 4338591 TI - Amino acid sequence of human apoLp-Gln-II (apoA-II), an apolipoprotein isolated from the high-density lipoprotein complex. AB - An apolipoprotein, designated by its carboxyl-terminal residue as apoLp-Gln-II, has been isolated from the human high-density lipoprotein family, and its complete aminoacid sequence was determined. The apoprotein, one of the two major apoproteins of this family, is composed of two identical polypeptide chains, each containing 77 amino acids. The two polypeptide chains are connected by a single disulfide bridge at position 6 in the sequence. The minimum molecular weight of the intact apoprotein is 17,380. The amino-terminal residue of each chain is pyrrolidone carboxylic acid, and the carboxyl-terminal residue is glutamine. PMID- 4338592 TI - Spin-label studies of dynamics of lipid alkyl chains in biological membranes: role of unsaturated sites. AB - Cultures of a yeast mutant, deficient in the synthesis of unsaturated fatty acids, were supplemented with either stearolic acid or with any one of three octadecanoic acids having a cis double bond 6, 9, or 11 carbons away from the acyl group. The resulting cells, with lipid alkyl chains well defined with respect to the position and nature of unsaturated sites, were then studied with spin-labeled stearic acids having a N-oxyloxazolidine ring located at 4, 6, 9, or 12 carbons away from the acyl group, and added in vitro to the cellular preparations. Differences in the molecular motion of each spin label were observed, as a function of the unsaturated site, in the intact yeast cells. Characteristic order to disorder phase transitions are inferred from data of temperature dependence. The results also indicate that triple bonds and cis double bonds inhibit a relatively ordered packing of lipid alkyl chains in the region between unsaturated sites and terminal methyl groups, leaving the hydrophobic region bounded by acyl groups and unsaturated sites unaffected. PMID- 4338593 TI - Cytochalasin B: inhibition of glucose and glucosamine transport. AB - Cytochalasin B has been shown to potently inhibit the transport of glucose, deoxyglucose, and glucosamine by Novikoff hepatoma cells in suspension culture without affecting their intracellular phosphorylation and metabolism. Deoxyglucose transport is inhibited by cytochalasin B in a simple competitive manner. Although this inhibition is not sufficient to explain the biological action of the drug on cytokinesis, it does explain earlier observations on inhibition by cytochalasin B of the incorporation of glucose and glucosamine, and probably of other extracellular precursors, into macromolecules by various types of cells. PMID- 4338594 TI - Measurement of transmembrane potentials in phospholipid vesicles. AB - Phosphatidylcholine vesicles are permeable to tempotartrate, a spin-label derivative of tartaric acid. The inside-outside distribution of tempotartrate is coupled to the inside-outside distribution of H(+), so it must be a measure of the transmembrane electrical potential difference in vesicles permeable to H(+). This prediction is borne out by the finding that the inside-outside distribution of tempotartrate is the reciprocal of the inside-outside distribution of K(+) in vesicles prepared in the presence of valinomycin. The inside-outside distribution of tempotartrate is, by contrast, equal to the inside-outside distribution of Cl( ) in vesicles without valinomycin. This is evidence that an inside-outside Cl(-) concentration gradient induces an H(+) gradient, which must be due to HCl permeation. PMID- 4338595 TI - Correlation of messenger RNA function with adenylate-rich segments in the genomes of single-stranded RNA viruses. AB - Oligonucleotides enriched in adenylate residues have been demonstrated in the genomes of two positive-strand RNA viruses, Sindbis and Columbia SK. Such oligonucleotides were not found in the genome of vesicular stomatitis virus, a negative-strand virus. The adenylate-rich oligonucleotides from Sindbis and Columbia SK viruses appeared similar when analyzed by zonal sedimentation in sucrose-sodium dodecyl sulfate. PMID- 4338596 TI - Strand orientation of simian virus 40 transcription in productively infected cells. AB - Strand orientation of transcription in BSC-1 cells infected by simian virus 40 (SV40) was investigated by annealing RNAs extracted from infected cells with asymmetric complementary RNA from SV40 DNA synthesized in vitro by RNA polymerase from Escherichia coli. The results suggest that the early viral RNA sequences (those made before replication of viral DNA) and the late RNA sequences (those synthesized concurrently with replication of viral DNA) are transcribed from opposite strands of the SV40 DNA. The RNA synthesized in vitro is of the same polarity as the early in vivo RNA and is complementary to the late in vivo RNA. Knowledge of strand selection in lytic infection is a step towards understanding the regulation of transcription of this viral DNA. PMID- 4338597 TI - Endogenous RNA-directed DNA polymerase activity in uninfected chicken embryos. AB - Early chicken embryos that are either positive or negative for group-specific antigens of avian leukosis viruses contained endogenous RNA-directed DNA polymerase activity. This endogenous DNA polymerase activity was not increased after mixture of soluble DNA polymerases isolated from chicken embryos with disrupted chicken embryo cells. The endogenous activity was resistant to treatment with deoxyribonuclease, and the initial rate of DNA synthesis was partially resistant to actinomycin D. In contrast, over 90% of the endogenous polymerase activity was destroyed by ribonuclease in medium with high salt concentration. The DNA product of the endogenous DNA polymerase activity from chicken embryos did not hybridize with RNA of Rous sarcoma virus or reticuloendotheliosis virus, whereas about 40% of this DNA product hybridized with the RNA from the same chicken-cell fraction. Antibody against DNA polymerase of avian myeloblastosis virus did not neutralize the chicken endogenous DNA polymerase activity. These results demonstrate that uninfected chicken embryo cells contain endogenous RNA-directed DNA polymerase activity that is not derived from avian leukosis or reticuloendotheliosis viruses. PMID- 4338598 TI - RNA-primed DNA synthesis in vitro. AB - In vitro DNA synthesis on single-stranded circular DNA can be initiated by RNA primers. RNA chains are covalently extended by DNA polymerase II from KB cells and DNA polymerase I from Micrococcus luteus, but not by an RNA-dependent DNA polymerase from avian myeloblastosis virus. The reaction product consists of DNA chains with a piece of RNA at their 5'-ends, hydrogen bonded to the template DNA. The primer RNA is linked to the product DNA via a 3':5'-phosphodiester bond, and can be specifically removed by ribonuclease H. The possible role of ribonuclease H in RNA-primed DNA synthesis in vivo is discussed. PMID- 4338599 TI - Canine herpesvirus respiratory infection. PMID- 4338600 TI - Effect of starvation on enzymes, glycogen and neutral fat in livers of sheep and cattle: a histochemical study. PMID- 4338601 TI - Canine adenovirus in organ cultures. PMID- 4338602 TI - Periodate--an inhibitor of the scrapie agent? PMID- 4338603 TI - Action of an alcoholic solution of iodine on the scrapie agent. PMID- 4338604 TI - [3 cases of gastrointestinal colloid adenocarcinoma: esophagus (Dawson's syndrome), stomach and colon]. PMID- 4338605 TI - [Viral oncolysis. A therapeutic essay]. PMID- 4338607 TI - [The role of electron microscopy in the differential diagnosis of neoplasms of vascular origin]. PMID- 4338606 TI - [Utilization of cascade superfusion technic for the determination of renin in the plasma]. PMID- 4338608 TI - Bronchiolo-alveolar carcinoma of the lung. PMID- 4338609 TI - Hepatocellular carcinoma in Nigerians: a study of 144 autopsy proven cases (1958 1968). PMID- 4338610 TI - Pancreatic tumour with diarrhoea, hypokalemia and hypochlorhydria. Report of a case, with clinical, radiological and histopathological studies. PMID- 4338611 TI - Herpes zoster ophthalmicus with nasociliary nerve involvement. PMID- 4338612 TI - A double blind clinical study of adenine arabinoside therapy of viral keratoconjunctivitis. PMID- 4338614 TI - An automatic high-precision acrylamide gel fractionator. PMID- 4338613 TI - Difference in interferon response and protection from ocular virus infection in rabbits and monkeys. PMID- 4338615 TI - Gas chromatographic method for determination of 2'-O-methylation in RNA. PMID- 4338616 TI - Isolation of ribonucleic acid from animal tissue by use of chaotropic agents. PMID- 4338617 TI - Identification of phenylthiohydantoins of amino acids by thin-layer chromatography on a plastic-backed silica-gel plate. PMID- 4338618 TI - Fluorometric assay of serum 5'-nucleotide phosphodiesterase in normal humans and cancer patients. PMID- 4338619 TI - Determination of phospholipid composition of RNA tumor viruses by 32 P labeling of infected cell cultures. PMID- 4338620 TI - Interactions of mineral fiber surfaces with cells in vitro. PMID- 4338621 TI - [Secreting langerhansian insulinoma. Clinical, biological, arteriographical and ultrastructural study of a case]. PMID- 4338622 TI - Activity of mitochondrial oxidative enzymes in tissues from young mice infected with Coxsackie A 10 virus. PMID- 4338623 TI - Regulation of iodine metabolism in human leukocytes by adenosine 3',5' monophosphate. PMID- 4338624 TI - Comparative studies of serums of mice inoculated with B. pertussis. PMID- 4338626 TI - [A simple thin-layer chromatographic method to determine the triglycerid cholesterol content of skin tumors]. PMID- 4338625 TI - Paraneoplastic syndromes resulting from elaboration of ectopic hormones, antigens and bizarre toxins. PMID- 4338627 TI - A rapid diagnostic aid for herpesvirus hominis infections in dermatology. PMID- 4338628 TI - [The increased activity of microbial neuramidase in low hydrogen peroxide concentrations]. PMID- 4338630 TI - [Synthesis of the human adrenal cortex hormone ( h ACTH) with a revised amino acid sequence]. PMID- 4338631 TI - A study of the reduced species of cobalt and nickel complexes analogous to vitamin B 12 . PMID- 4338629 TI - A messenger RNA from the lactose operon of Escherichia coli that can not direct the production of functional -galactosidase in absence of exogenous adenosine 3',5-cyclic monophosphate. AB - In a temperature-sensitive mutant of Escherichia coli, beta-galactosidase cannot be induced at the nonpermissive temperature (43 degrees C) without the addition of exogenous 3', 5'-cyclic AMP (cAMP), although the intracellular concentration of this nucleotide is normal. This specific effect of cAMP is probably general in this strain for those operons which are controlled by the cAMP receptor protein and cAMP, but not for other parts of the chromosome. The lac mRNA produced at 43 degrees C in absence of cAMP is transcribed from the correct DNA strand and it directs the synthesis of enzymatically inactive material cross-reacting with beta galactosidase. Experiments separating transcription from translation by using rifampicin, suggest that cAMP exerts its effect during initiation of transcription or translation of lac mRNA, but does not affect the propagation of either the messenger or of the beta-galactosidase polypeptide chain. PMID- 4338632 TI - Chloroperoxidase. IX. The structure of compound I. PMID- 4338633 TI - Newer concepts in the diagnosis and therapy of malignant trophoblastic disease. PMID- 4338634 TI - The fine structure of the ependymal tanycytes at the level of the arcuate nucleus. PMID- 4338635 TI - Immunological reactivity of antisera prepared against the sodium dodecyl sulfate treated structural polypeptides of adenovirus-associated virus. AB - The preparation of antisera to the three purified sodium dodecyl sulfate (SDS) treated polypeptide components (VP1, VP2, VP3) of adenovirus-associated virus (AAV) type 3H is described. In immunofluorescence tests (FA), these antisera stained heat-stable antigens with distinct morphologies in cells co-infected with either adenovirus or herpes simplex virus. Kinetic studies of antigen formation showed that VP1 antiserum first stained the cytoplasm (14 hr) and later (by 18 hr) stained both cytoplasmic and intranuclear areas. VP2 antiserum stained only discrete intranuclear areas, and VP3 antiserum stained nearly the entire nucleus. All three VP antigens appeared at about the 14th hr postinfection, about 2 hr prior to the appearance of whole virion antigen. The VP antisera cross-reacted in FA with AAV types 1 and 2 (all at one-eighth of the homologous titer), but did not react with other parvoviruses, i.e., rat virus, hemadsorbing enteric virus of calves, minute virus of mice, or H-1 virus. These non-neutralizing antisera reacted specifically with SDS-treated AAV virion antigens in complement fixation and immunodiffusion tests, and antiserum prepared against SDS-treated helper adenovirus structural polypeptides reacted with adenovirus polypeptide antigens. All antisera to SDS-treated polypeptides were specific for new antigens revealed on the dissociated peptides and did not react with whole virions, whereas whole virion antisera did not cross-react with the polypeptide antigens. These findings suggest that antigens unique to the polypeptides of AAV are revealed by SDS treatment and that these antigens can be detected in cells prior to the folding of the polypeptides into the molecular configuration they possess as virion subunits. These results also indicate that at least one AAV polypeptide component is synthesized in the cell cytoplasm. PMID- 4338636 TI - Incorporation of L cell sterols into vesicular stomatitis virus. AB - The incorporation of host cell sterol into vesicular stomatitis virus can be effectively studied in an L cell system. The end product of de novo sterol synthesis in the L cell is desmosterol, and as the concentration of cholesterol in the medium is increased the cells incorporate the exogenous cholesterol and the synthesis of desmosterol decreases. L cells which contained desmosterol as their sole sterol produced virus whose sterol content was similarly composed of only desmosterol. Virus grown in L cells which had a constantly changing sterol ratio also contained a mixture of cholesterol and desmosterol, but the virus was found to be more enriched in cholesterol than in the L cells in which it was grown. Viral stability, growth, and plaquing efficiency were tested and found not to be affected by the alteration of its sterol composition, i.e., by partially or completely replacing cholesterol with desmosterol. PMID- 4338637 TI - Virus-specific ribonucleic acid in cells producing rous sarcoma virus: detection and characterization. AB - Cells producing Rous sarcoma virus contain virus-specific ribonucleic acid (RNA) which can be identified by hybridization to single-stranded deoxyribonucleic acid (DNA) synthesized with RNA-directed DNA polymerase. Hybridization was detected by either fractionation on hydroxyapatite or hydrolysis with single strand-specific nucleases. Similar results were obtained with both procedures. The hybrids formed between enzymatically synthesized DNA and viral RNA have a high order of thermal stability, with only minor evidence of mismatched nucleotide sequences. Virus specific RNA is present in both nuclei and cytoplasm of infected cells. This RNA is remarkably heterogeneous in size, including molecules which are probably restricted to the nucleus and which sediment in their native state more rapidly than the viral genome. The nature of the RNA found in cytoplasmic fractions varies from preparation to preparation, but heterogeneous RNA (ca. 4-50S), smaller than the viral genome, is always present in substantial amounts. PMID- 4338638 TI - Ribonucleic acid synthesis of vesicular stomatitis virus. IV. Transcription by standard virus in the presence of defective interfering particles. AB - Exposure of vesicular stomatitis virus-infected Chinese hamster ovary cells to cycloheximide results in the complete transcription of virion ribonucleic acid (RNA) into only 28S and 13 to 15S viral-specific RNA species. These RNA are identical to viral messenger RNA by the following criteria: size, single strandedness, complementarity to virion RNA, and formation of messenger ribonucleoproteins. This transcription represents the intracellular enzymatic activity of the virion-associated polymerase and is shown to be dependent on input multiplicity. Intracellular transcription differs from in vitro polymerase activity in having a temperature optimum of 34 to 37 C and in synthesizing 28S as well as 13 to 15S messenger RNA species. Addition of interfering quantities of defective T particles to these cycloheximide-treated cells, either an hour before or at the same time as standard B particles of vesicular stomatitis virus, does not alter the rate of transcription nor does it change the sucrose gradient pattern of the viral RNA species. From these results it is concluded that the RNA of defective T particles does not serve a transcriptive function and probably interferes through the replicative mechanism for virion RNA synthesis. PMID- 4338639 TI - Structure and function of the polypeptides in simian virus 40. II. Transcription of subviral deoxynucleoprotein complexes in vitro. AB - A deoxynucleoprotein complex (DNP-1) isolated from simian virus 40 (SV40) after disruption of the virus in an alkaline buffer contains the viral deoxyribonucleic acid (DNA) and four minor structural polypeptides. Dissociation of DNP-I by equilibrium centrifugation in CsCl yields a complex (DNP-II) that contains a small amount of polypeptide tightly bound to the viral DNA. Studies of the template activity of these deoxynucleoprotein complexes in vitro with Escherichia coli transcriptase show that the rate of transcription of DNP-I and DNP-II is 30 and 80%, respectively, compared with that of deproteinized SV40 DNA component I. In dimethyl sulfoxide gradients, the complementary ribonucleic acid (cRNA) synthesized from DNP-I is one-third to one-half the size of the cRNA species from DNA-I and DNP-II. Competition hybridization experiments show that with the E. coli transcriptase only a portion (about one-half) of the SV40 genome is transcribed with DNP-I as template, whereas most or all of the genome is transcribed with DNP-II as template. The template activity of the deoxynucleoprotein complexes with a highly active form II ribonucleic acid polymerase prepared from SV40-infected permissive cells follows similar transcription kinetics. The results indicate that structural nucleoproteins of SV40 bind nonrandomly to the viral DNA and effect the transcription of some subset of its sequences in vitro. PMID- 4338640 TI - Genome homology of vesicular stomatitis virus and defective T particles and evidence for the sequential transcription of the virion ribonucleic acid. AB - The small defective T particle of vesicular stomatitis virus (VSV-111) has no detectable enzyme activity when assayed at 31 C, although qualitatively it possesses all the virion proteins found in complete VSV-1 virions. With VSV-1 transcription product ribonucleic acid (RNA), it is shown that the VSV-111 RNA is identical to part of the VSV-1 genome. Evidence is also presented to support the idea that in vitro VSV-1 transcription is sequential. PMID- 4338642 TI - Genetic analysis of simian virus 40. IV. Inhibited transformation of Balb-3T3 cells by a temperature-sensitive early mutant. AB - The temperature-sensitive early mutant, ts(*)101, was characterized during productive infection in monkey cells, and the results are presented in an accompanying paper. This paper demonstrates that although 101 mutant virions adsorb normally to confluent Balb/3T3 mouse cells at both permissive (33 C) and restrictive (38.5 C) temperatures, T antigen synthesis and transformation, abortive and stable, are inhibited at both temperatures (host-range inhibition). T antigen synthesis is temperature sensitive, whereas abortive and stable transformation are not. Clones of 101-transformed Balb/3T3 cells were isolated, and virus was rescued from all clones at both permissive and restrictive temperatures. The rescued virus was as temperature sensitive as the original transforming 101 virions. PMID- 4338641 TI - Genetic analysis of simian virus 40. 3. Characterization of a temperature sensitive mutant blocked at an early stage of productive infection in monkey cells. AB - A temperature-sensitive mutant of simian virus 40 (SV40), ts(*)101, has been characterized during productive infection in monkey kidney cells. The mutant virion can adsorb to and penetrate the cell normally at the restrictive temperature, but cannot induce the synthesis of cellular deoxyribonucleic acid (DNA) nor initiate the synthesis of SV40-specific tumor, virion, or U antigens or viral DNA. First-cycle infection with purified ts(*)101 DNA is normal at the restrictive temperature, but the resulting progeny virions are still temperature sensitive. The mutant neither complements nor inhibits other temperature sensitive SV40 mutants or wild-type virions. The affected protein in the ts(*)101 mutant may be a regulatory structural protein, possibly a core protein, that is interacting with the viral DNA. PMID- 4338643 TI - [Hepatic extraction and clearance of renin in liver cirrhosis]. PMID- 4338645 TI - [Determination of plasma renin activity using the radioimmunoassay for angiotensin I]. PMID- 4338647 TI - [Inclusional cytomegalia]. PMID- 4338644 TI - [Regulation of the renin-angiotensin system in congestive heart failure: indications for a total body sodium-dependent regulation of the renin secretion]. PMID- 4338646 TI - [Solubility of collagen in fibrinolytic agents]. PMID- 4338648 TI - [Potential malignancy of the pleomorphic adenoma of the parotid gland]. PMID- 4338649 TI - [Intramucosal gastric neoplasm. Case in a 25-year-old woman]. PMID- 4338650 TI - Utilization of niacin and niacinamide for NAD formation in rat liver. PMID- 4338651 TI - [Influence of aflatoxin B 1 on the glucose-6-phosphatase activity of the rat liver (Rattus norvegicus albinus)]. PMID- 4338652 TI - [Symptomatologic study of plasma ACTH]. PMID- 4338653 TI - [Cutaneous forms of breast cancer: Paget's disease and erysipeloid carcinoma]. PMID- 4338655 TI - [Function of paradoxical sleep in the retention of memory]. PMID- 4338654 TI - Canine adenovirus respiratory disease: isolation of infectious canine hepatitis virus from natural cases and the experimental production of the disease. PMID- 4338657 TI - Effects of hyperbaric oxygenation and reduced barometric pressure on the nucleic acid contents of healing fractures. A biochemical study with rats. PMID- 4338656 TI - [Diagnostic and clinical problems in the congenital adrenogenital syndrome]. PMID- 4338658 TI - The healing pattern of the drum membrane. PMID- 4338659 TI - [Transmembrane ionic currents in heart cells: applications to pharmacology]. PMID- 4338660 TI - [The pharmacological modifications of synaptic transmission at the level of the encephalon]. PMID- 4338661 TI - [Premature interruption of pregnancy in acute respiratory viral diseases]. PMID- 4338662 TI - Recurrent respiratory failure associated with the absence of ventilatory response to hypercapnia and hypoxemia. PMID- 4338663 TI - In vitro studies of the foamy macrophage of postobstructive endogenous lipoid pneumonia in man. PMID- 4338664 TI - I-Anilino-8-naphthalene sulfonate as a coenzyme-competitive inhibitor of yeast glyceraldehyde-3-phosphate dehydrogenase: multiple inhibition studies. PMID- 4338665 TI - Glycogen synthetase of rat skeletal muscle and hepatomas and its comparison with the enzyme of rat liver. PMID- 4338666 TI - Photoinactivation of microsomal glucose-6-phosphatase. PMID- 4338667 TI - Protein-bound phosphoryl histidine: a probable intermediate in the microsomal glucose-6-phosphatase-inorganic pyrophosphatase reaction. PMID- 4338669 TI - [In vivo action of a curare on adenylcyclase activity]. PMID- 4338668 TI - Comparison of surgery and prolonged spironolactone therapy in patients with hypertension, aldosterone excess, and low plasma renin. AB - The effect of prolonged preoperative treatment with spironolactone has been studied in a series of 67 patients with hypertension, aldosterone excess, and low plasma renin. In the series as a whole a highly significant reduction in both systolic and diastolic pressures was achieved, with no evidence of escape from control during therapy lasting several years in some cases. The drug was equally effective in controlling blood pressure in patients with and without adrenocortical adenomata. Occasional unresponsive patients were encountered in both groups; pretreatment blood urea levels in these were significantly higher than in the responsive patients. The hypotensive effect of spironolactone usually predicted the subsequent response to adrenal surgery.Spironolactone in all cases corrected plasma electrolyte abnormalities; significant increases in total exchangeable (or total body) potassium and significant reductions in total exchangeable sodium, total body water, extracellular fluid, and plasma volumes were seen. Plasma urea rose during treatment and there was a slight fall in mean body weight. Significant increases in peripheral venous plasma renin and angiotensin II concentrations occurred during treatment.In two patients no increase in aldosterone secretion rate was found during treatment, although plasma aldosterone rose in three of four subjects studied.Severe side effects were rare; in only two of the 67 patients did the drug have to be stopped.In addition to its routine preoperative use, spironolactone can now be advised as long-term therapy in selected patients. PMID- 4338671 TI - [Isolation of "minus" chain of ribonucleic acid of the murine encephalomyocarditis virus and study of its infectivity]. PMID- 4338670 TI - [Seasonal variations and metabolic orientation of some biochemical constituents of carbohydrate metabolism of the active dormouse, Glis-glis (L.)]. PMID- 4338672 TI - Antigenic relationships of equine herpesvirus strains demonstrated by the plaque reduction and neutralization kinetics tests. AB - The antigenic relationships among 50 strains of equine herpesvirus (EHV) were studied by neutralization tests using antisera prepared in rabbits against four EHV reference strains: types 2 and 3, cytomegalo-like virus 82-A, and our leukocyte isolant H-40. No distinctive antigenic differences among reference strains were demonstrated in reciprocal neutralization tests but each antiserum neutralized its homologous virus more rapidly than any heterologous strain. Forty six EHV strains isolated from peripheral blood leukocytes of apparently healthy horses were antigenically indistinguishable from each other and from the four reference strains. Their high degree of antigenic relatedness suggests that these viruses are isolants of a single, widely distributed serotype of which type 2 (LK) strain is a typical representative. PMID- 4338673 TI - A micro-passive hemagglutination test for the rapid detection of antibodies to infectious bovine rhinotracheitis virus. AB - Serum antibodies to infectious bovine rhinotracheitis virus are most commonly detected using the serum-virus-neutralization test, a time-consuming and expensive procedure. A passive hemagglutination test was developed for the rapid detection of antibodies using the Microtiter System. Two cloned strains of the virus were used in the investigation, namely the BF strain and the Los Angeles strain. Erythrocytes from several species were used. The best results were obtained using the Los Angeles strain of virus adsorbed to sheep cells treated with formalin and tannic acid. Sera from field cases of the disease as well as hyperimmune bovine and rabbit sera were tested using both the micro-passive hemagglutination test and the standard plaque-neutralization procedures. Comparable titers were obtained in the two tests. The micro-passive hemagglutination test is rapid, accurate and economical. PMID- 4338674 TI - Angiography in synovial disease. PMID- 4338675 TI - Unusual diagnostic problems of the foot. PMID- 4338677 TI - [Studies of the pattern of free fatty acids in the blood plasma of rabbits in experimental nephrogenic hypertension and following administration of angiotensin II]. PMID- 4338676 TI - Surgery in liver tumors. PMID- 4338678 TI - [Enzyme patterns in the nephron. Quantitative histochemical results]. PMID- 4338679 TI - Multiple phases in the reduction of xanthine oxidase by substrates. PMID- 4338680 TI - F1-histone modification at metaphase in Chinese hamster cells. PMID- 4338682 TI - Study of the growth response of normal and SV40-transformed 3T3 mouse fibroblasts with serum fractions obtained by use of organic solvents. PMID- 4338681 TI - Accumulation of calcium in the intramitochondrial dense bodies in mice. PMID- 4338683 TI - Secretion of RNA by normal and transformed cells. PMID- 4338684 TI - Antigenicity of phosphatidyl inositomannosides of Mycobacterium tuberculosis. PMID- 4338685 TI - Cytophagia in cell cultures infected with cytomegalovirus. PMID- 4338686 TI - Effects of hyperkalaemia on the excitability of peripheral nerve. AB - An experimental animal model has been developed for the study of excitability change in peripheral nerve during limb ischaemia. This model has been used to investigate the effects of hyperkalaemia on the sequence of excitability change that occurs during cuff-induced limb ischaemia and in the post-ischaemic recovery period. The results lend support to the hypothesis that the dynamics of K ion concentration in the periaxonal space play a critical role in determining these excitability changes and that the polyanionic mucopolysaccharide gap substance of the node of Ranvier is likely to constitute the diffusion barrier that defines the periaxonal space. PMID- 4338688 TI - Familial gliomas. Report of four cases. PMID- 4338687 TI - Conduction in unmyelinated fibres in experimental neuropathy. AB - Conduction velocity of autonomic unmyelinated fibres has been measured in the cervical sympathetic trunk of normal rats, and in rats intoxicated by acrylamide or by isoniazid. The mean maximal conduction velocity in nerves from normal rats is 2.0 m/sec. There is no significant reduction in velocity of the unmyelinated fibres in nerves from intoxicated rats, although histological studies of the sural nerve confirmed severe degeneration of myelinated fibres in the same animals. It is shown that the amplitude of the compound nerve action potential is proportional to the resistance between the recording electrodes. If this is taken into account, there is no reduction in the amplitude of the monophasic action potential of unmyelinated fibres recorded from the cervical sympathetic trunk of intoxicated rats. The amplitude of the A component of the sural nerve compound action potential is markedly reduced in rats intoxicated by acrylamide or by isoniazid, but there is no significant reduction in the amplitude of the C component in the same nerve. It is concluded that in the rat an insignificant number of unmyelinated fibres of autonomic or dorsal root origin are affected in the neuropathy produced by acrylamide or isoniazid. The relevance of these findings to human neuropathies is discussed. PMID- 4338689 TI - Cell kinetics of human gliomas. PMID- 4338690 TI - Lack of correlation between clinical and angiographic findings in patients with brain tumors under BCNU chemotherapy. PMID- 4338692 TI - Potentiation and depression of synaptic transmission in the olfactory cortex of the guinea-pig. AB - 1. The extracellular field potentials of the olfactory cortex evoked by stimulation of the lateral olfactory tract (l.o.t.) were studied in in vitro preparations from the olfactory cortex. The field potentials comprised an initial diphasic wave - the l.o.t. compound action potential - followed by a negative wave of about 10 msec duration which in turn was followed by a low amplitude positive wave of long duration (100 msec or more). In this paper, the size of the negative field potential (extracellularly recorded EPSP) has been studied during and after periods of repetitive stimulation of the l.o.t.2. If two identical volleys were delivered to the l.o.t. the second evoked EPSP was not the same size as the conditioning EPSP. At brief conditioning intervals (up to 10 msec) the second (test) EPSP was smaller than the control. For conditioning intervals between 10 and 200 msec, the test EPSP was potentiated over the control. For long conditioning intervals (300 msec up to 5 sec) the test EPSP was again slightly smaller than the control EPSP. After a brief conditioning train, the depression of a test EPSP (elicited 300 msec or more after the conditioning train) was more pronounced and lasted longer. These changes of test EPSP size were attributed to the presence of two opposing processes: an initial potentiation superimposed on a more prolonged but less pronounced depression.3. During prolonged repetitive stimulation the final steady amplitude of an EPSP varied with the frequency of stimulation. At low frequencies (0.5-2/sec) the steady EPSP amplitude was 90-95% of the initial control amplitude. At moderate frequencies (5-20/sec) the steady EPSP amplitude was greater than the initial control. At high frequencies (above 20/sec) the steady amplitude of the EPSPs declined with increasing frequency of stimulation. Potentiation of EPSPs was observed early in a train of impulses when the stimulation frequency was 5-70/sec.4. After a large number of stimuli at frequencies from 20 to 100/sec the amplitude of individual, infrequently evoked, EPSPs passed through a phase of depression that lasted about 30 sec. This depression was followed by a phase of potentiation (post-tetanic potentiation). The amplitude and duration of post-tetanic potentiation appeared to depend on the characteristics of the conditioning train.5. The discussion compares the results obtained with those obtained for other mammalian synapses. It is suggested that the transmitter in the presynaptic terminals could be in three parts, (a) immediately available transmitter (b) conditionally available transmitter requiring a single nerve impulse for its availability and (c) main depot transmitter which replenishes the other two stores. Potentiation and depression of evoked EPSPs were interpreted in terms of changes in the amount of transmitter released by the test volley. According to this analysis, a fixed proportion (about 10%) of the immediately available transmitter is released by each nerve impulse. PMID- 4338691 TI - Reflex discharge patterns of cardiac vagal efferent fibres. AB - 1. Unit activity was recorded from single and few fibre preparations in a cardiac branch of the right vagus nerve of the cat.2. Increases in blood pressure mediated solely by the right carotid sinus nerve produced bradycardia when all other nerves to the heart had been cut. Myelinated fibres in the cardiac branch of the right vagus nerve were reflexly activated by the same procedure.3. The fibres were silent when blood pressure was below 140-150 mm Hg. As the pressure began to rise, they discharged phasically with the cardiac cycle. At pressures greater than 180 mm Hg, the discharge was continuous attaining maximum rates of 40/sec.4. Stimulation of carotid body chemoreceptors also reflexly excited these fibres, as did stimulation of baroreceptors in both the left carotid sinus and aortic arch. Afferent fibres in the left vagus discharging in response to changes in blood pressure reflexly excited the cardiac efferent fibres. Increases in phrenic motoneurone discharge coincided with inhibition of these fibres. Electrical stimulation of the glossopharyngeal nerve also produced inhibition. PMID- 4338694 TI - The measurement of blood concentrations of angiotensin I in man. PMID- 4338693 TI - The effects of drugs on noradrenaline and dense-cored vesicles in ligated post ganglionic sympathetic nerves in vitro. PMID- 4338695 TI - Cultural diagnosis of Bordetella pertussis infection. PMID- 4338696 TI - Spontaneous heritable hydronephrosis in inbred mice. 1. Description, incidence, and distribution of lesions. PMID- 4338697 TI - Microbial flora of imported marmosets: viruses and enteric bacteria. PMID- 4338698 TI - Incidence of cardiac and other soft tissue mineralized lesions in DNA-2 mice. PMID- 4338699 TI - Osteoarthritis in guinea pigs. PMID- 4338700 TI - Effect of protein-calorie malnutrition on food consumption, weight gain, serum proteins, and activity in the developing rhesus monkey (Macaca mulatta). PMID- 4338701 TI - Tetanus in a free-ranging colony of Macaca mulatta: a clinical and epizootiologic study. PMID- 4338702 TI - Prothrombin time stability of avian and mammalian plasma: effect of anticoagulant. PMID- 4338703 TI - Penetrating thorns in the head and neck of Saimiri sciureus. PMID- 4338705 TI - The kinetics of sulfobromophthalein clearance in the rhesus monkey. PMID- 4338706 TI - Use of tracheostomized dogs in chronic metabolic assessments of treatmill work. PMID- 4338704 TI - Hematologic values for five northern microtines. PMID- 4338707 TI - A low-cost electronic cardiac auscultation device for monitoring rabbits under general anesthesia. PMID- 4338708 TI - A technic for massive skin grafting in rats. PMID- 4338710 TI - An improved method for monitoring oyster valve movement. PMID- 4338709 TI - Spontaneous neoplasms in aging gerbillinae. PMID- 4338711 TI - A new restraining device for testing antiradiation drugs in monkeys. PMID- 4338712 TI - An anesthetic unit for small laboratory animals. PMID- 4338713 TI - A technic for implanting a radioactive particle in a rodent lung. PMID- 4338714 TI - A protective device for mouse tail skin grafts. PMID- 4338715 TI - Effective sedation of laboratory animals using Innovar-Vet. PMID- 4338717 TI - Angora goat as an artificial ventilation model. PMID- 4338716 TI - Mammary gland tumors in collared lemmings (Dicrostonyx groenlandicus). PMID- 4338718 TI - Simian virus reference center and laboratory. PMID- 4338719 TI - [Presence of C-particle group-specific antigens in the liquid phase of mouse ascitic tumors]. PMID- 4338720 TI - An internally-controlled double blind trial of thalidomide in severe erythema nodosum leprosum. PMID- 4338721 TI - Lipids of Echinococcus granulosus protoscolices. PMID- 4338722 TI - Stearyl CoA as a precursor of oleic acid and glycerolipids in mammary microsomes from lactating bovine: possible regulatory step in milk triglyceride synthesis. PMID- 4338723 TI - [Effect of intramuscular, high-dose administered crystalline Vitamin D 3 in dissolved form, on serum calcium, phosphorus and magnesium levels in cows susceptible to hypocalcemic puerperal paresis (paresispuerperalis hypocalcaemica)]. PMID- 4338725 TI - N 6 ,O 2 '-dibutyryl adenosine 3',5'-monophosphate induces pigment production in melanoma cells. PMID- 4338724 TI - Structure and subunit interaction of haemoglobin M Milwaukee. PMID- 4338727 TI - Quantitative histological changes in the rat hypothalamus following bilateral adrenalectomy. PMID- 4338726 TI - Effect of osmotic stress and hormone therapy on the hypothalamus of the duck (Anas platyrhynchos). PMID- 4338728 TI - Acetylcholine system and neural development. PMID- 4338729 TI - Serum lipids and lipoprotein following acute myocardial infarction in women. PMID- 4338730 TI - [Modification of the levels of adenine nucleotides (ATP, ADP, and AMP), by illumination from a red-clear (660 nm) light]. PMID- 4338731 TI - Antimony trichloride as a test reagent for steroids, especially diosgenin and yamogenin, in plant tissues. PMID- 4338732 TI - [Enzyme deficiencies in pathogenesis of hypertension]. PMID- 4338733 TI - [Australia antigen in hepatitis: technical and clinical aspects]. PMID- 4338735 TI - [Central regulation of the activity of the sympathetic-adrenergic system of the light of present-day data]. PMID- 4338734 TI - [Hormone determination with the radio-immunologic method]. PMID- 4338736 TI - On the possible relation between different pools of adrenergic transmitter and heterogeneity or amine storage granules in nerve terminals. PMID- 4338737 TI - [Present-day views on the formation and biological inactivation of endogenous catecholamines]. PMID- 4338738 TI - [The role of norepinephrine and dopamine in synaptic transmission of vegetative ganglions]. PMID- 4338739 TI - [Some aspects of the physiological role of dopamine as a synaptic transmitter in basal ganglia and caudate nucleus]. PMID- 4338740 TI - [IR-spectroscopic studies on the surface reactions of aerosil]. PMID- 4338741 TI - Partial glyceridase activity of a protein-kinase activatable triglyceride lipase from rat adipose tissue. PMID- 4338742 TI - The effect of tetracycline on the hepatic secretion of triglyceride. PMID- 4338743 TI - A second form of hormone-sensitive lipase from rat adipose tissue homogenates. PMID- 4338744 TI - Lipolysis in the adipose tissue of mice made obese with goldthioglucose. PMID- 4338745 TI - The fragments of the photosynthetic electron transfer chain in model systems. AB - In this paper the recent research from our laboratory is reviewed. Short fragments of the photochemical electron transfer chain of photosynthesis were reproduced in aqueous detergent solutions or in organic solvents. The function of photosystem I is reproduced in a ternary system of chlorophylls, electron donors (dienols, sulfhydryl compounds, hydrazine, etc.), and electron acceptors (viologens, nicotinamide-adenine dinucleotide [NAD], flavines, etc.). Chlorophyll photosensitized reduction of viologens in some cases is activated by oxygen at the expense of active reductants formed during the photosensitized oxidation of an initial electron donor (thiourea). Chlorophyll-photosensitized oxidoreduction of cytochromes is activated by flavines, viologens, vitamin K derivatives, and some other redox systems (cofactors of cyclic photophosphorylation). The primary mechanism of the reactions studied depends on the reversible chlorophyll photooxidoreduction. In binary systems, chlorophyll (monomeric or aggregated) and electron donor or electron acceptor, reversible photoreduction or photooxidation is observed. Irreversible bacteriochlorophyll oxidation leads to the formation of chlorophyll and protochlorophyll analogues; irreversible protochlorophyll photoreduction results in chlorophyll-like pigment appearance. The photodisaggregation of chlorophyll was observed. The models of photosystem II studied were the photochemical oxygen evolution in aqueous solutions of electron acceptors (ferric compounds, quinone), photosensitized in the near UV part of the spectrum by inorganic semiconductors (tungsten, titanium, and zinc oxides). All reactions described are based on electron (hydrogen) transfer photosensitized by pigment system. PMID- 4338747 TI - [Control of the extracellular fluid]. PMID- 4338746 TI - The photoreduction of nicotinamide-adenine dinucleotide by chromatophore fractions from Rhodospirillum rubrum. AB - The photoreduction of nicotinamide-adenine dinucleotide (NAD(+)), catalyzed by chromatophore fractions from young (1 day) and old (4-5 days) cultures of Rhodospirillum rubrum, was measured in the presence of either succinate or 2,6 dichlorophenol indophenol (DPIP) and an excess of ascorbate. The time-course of photoreduction in the succinate system suggested a "reversed electron flow" from the donor to NAD(+) mediated by a high energy intermediate produced by a light induced, cyclic electron transport in the chromatophore fractions. The effects of the uncoupler carbonyl cyanide [p-(trifluoromethoxy)phenyl]hydrazone (FCCP) and of the inhibitors antimycin A and 2-heptyl-4-hydroxyquinoline-N-oxide (HQNO) were consistent with this interpretation. The time-course of NAD(+) photoreduction in the presence of DPIP and ascorbate suggested a direct, light-induced electron transport from the donor to the acceptor. We cannot yet distinguish between a model in which the same reaction center is utilized in the photoreduction by both donor systems (the reaction center component P-870 may relate to two primary acceptors at different redox potential levels) and a model in which each photoreducing system is driven by its own reaction center component. PMID- 4338748 TI - [Lipid and fatty acid composition in brain tumors]. PMID- 4338749 TI - [Silicone oil (dimethylpolysiloxane) and nerve tissue damage--pathogenesis of silicone retinopathy as an example]. PMID- 4338750 TI - [Ultrastructure of the sural nerve in the convalescent stage of acute uremic neuropathy due to sodium bromate intoxication]. PMID- 4338751 TI - [Surgical forms of cancer in the African child in Dakar (apropos of 50 cases)]. PMID- 4338753 TI - [Evolution of endocytosis]. PMID- 4338752 TI - [Nasolabial secretions during paradoxical sleep in bovine animals]. PMID- 4338754 TI - [Malignant mixed tumors of the large and small salivary glands]. PMID- 4338755 TI - Enhancement of sympathetic neurotransmission by prostaglandin F 2 in the cutaneous vascular bed of the dog. PMID- 4338756 TI - Effect of various antibiotics on neuromuscular transmission. PMID- 4338757 TI - Actions of lidoflazine on neuromuscular transmission. PMID- 4338758 TI - Chloroquine-induced depression of neuromuscular transmission. PMID- 4338759 TI - Perinatal encephalopathies caused by maternal diseases during pregnancy. PMID- 4338760 TI - Pattern of neoplasia in children--Kerala. PMID- 4338761 TI - Utility of liver biopsy in the diagnosis of carcinoma of the liver. PMID- 4338762 TI - Microsomal and lysosomal acid phosphatase isoenzymes of mouse kidney. Characterization and separation. PMID- 4338763 TI - Elemental analysis of precipitates formed in nuclei by antimonate-osmium tetroxide fixation. PMID- 4338764 TI - The histochemical demonstration of polyadenylic acid hydrolases in rat liver during azo dye carcinogenesis. PMID- 4338765 TI - Quartz fiber ultramicrobalance. PMID- 4338766 TI - Immunogenicity of leukemia L1210 cells after neuraminidase treatment. PMID- 4338767 TI - Immunotherapy of cancer: regression of intradermal tumors and prevention of growth of lymph node metastases after intralesional injection of living Mycobacterium bovis. PMID- 4338768 TI - Cross protection in vivo against avian sarcoma virus subgroups A, B, and C induced by Rous-associated viruses. PMID- 4338769 TI - Herpes-like simian viruses: retrospective and prospective considerations. PMID- 4338771 TI - Herpesviruses from the owl monkey (Aotus trivirgatus). PMID- 4338770 TI - Burkitt's lymphoma and Herpesvirus saimiri lymphoma: comparative aspects. PMID- 4338772 TI - Recovery and characterization of a new simian herpesvirus from a fatally infected spider monkey. PMID- 4338773 TI - Two new herpesviruses from spider monkeys (Ateles geoffroyi). PMID- 4338774 TI - Plaque characterization of viruses from South American nonhuman primates. PMID- 4338775 TI - Serologic evidence of viral infection in South American Monkeys. PMID- 4338776 TI - Clinical, epidemiologic, and pathologic features of cytocidal and oncogenic herpesviruses in South American monkeys. PMID- 4338777 TI - Fluorescent antibody studies on herpesviruses from new-world primates. PMID- 4338779 TI - Cutaneous papillomas on an opossum. PMID- 4338778 TI - Viruses and renal carcinoma of Rana pipiens. 13. Transmission of the Lucke tumor by herpesvirus-containing ascitic fluid from a tumor-bearing frog. PMID- 4338780 TI - Immune response in the hamster. VI. Antibody response in polyoma oncogenesis. PMID- 4338781 TI - Use of an established cat cell line for investigation and quantitation of feline oncornaviruses. PMID- 4338782 TI - Lymphomas in the Wistar rat after intrapleural inoculation of silica. PMID- 4338783 TI - Corticotropin therapy in patients with myasthenia gravis: steroid metabolism, and histology of skeletal muscle and thymus. PMID- 4338784 TI - Isolation of cell nuclei from ischemic renal tissue: biochemical characteristics of these nuclei. PMID- 4338785 TI - On alkaloids. XXV. Minor alkaloids of poppy capsules. PMID- 4338786 TI - [Drug and physical therapy of primary chronic polyarthritis]. PMID- 4338788 TI - [The Bartter syndrome and the pseudo-Bartter syndrome]. PMID- 4338787 TI - [Iatrogenic inhibition of longitudinal growth]. PMID- 4338789 TI - Parathyroid hormone as a trophic hormone for 1,25-dihydroxyvitamin D3, the metabolically active form of vitamin D. PMID- 4338790 TI - Early increase in nuclear acidic protein synthesis after SV40 infection. PMID- 4338791 TI - Stimulation by dibutyryl cyclic AMP of serotonin synthesis and tryptophan transport in brain slices. PMID- 4338792 TI - Extraction of K + selective channels from excitable tissue. PMID- 4338793 TI - Effects of changes in maternal pituitary-adrenal function on behavior of rat offspring. PMID- 4338794 TI - Lack of interaction between Sendai virus and bacterial cells. PMID- 4338795 TI - Spontaneous transformation of rat cells after long-term in vitro cultivation and the "switch-on" of a new complement-fixing antigen. PMID- 4338796 TI - Differential inhibition of nuclear RNA polymerases in L cells infected with mengovirus. PMID- 4338798 TI - HL cells, a sensitive line for the isolation and propagation of respiratory syncytial virus. PMID- 4338797 TI - Production of crude human interferon with high specific activity. PMID- 4338800 TI - Glucuronidase activity in intestinal contents of rat and man and relationship to bacterial flora. PMID- 4338799 TI - Combined action of 6-mercaptopurine and antibiotics on gram-negative bacteria in vitro. PMID- 4338801 TI - Cyclic 3',5'-AMP-dependent protein kinase activity in toad bladder epithelium. PMID- 4338802 TI - MSH-release-inhibiting factor: inactivation by proteolytic enzymes. PMID- 4338803 TI - Plasma ACTH and cortisol concentration of coronary-prone subjects. PMID- 4338804 TI - Cellular control of interferon production and release after treatment with poly I:C inducer. PMID- 4338805 TI - The fine structure of the fibrous membrane forming region of the isthmus of the oviduct of Gallus domesticus. PMID- 4338806 TI - Radical ion saturation in some sulfur compounds x-irradiated at 4.2 degrees K. PMID- 4338807 TI - Electron spin resonance studies and INDO MO-calculations of electron irradiated peptides. A single crystal of N-acetylglycine. PMID- 4338808 TI - Temperature dependence of the direct action of ionizing radiation on beef heart lactate dehydrogenase: enzyme activity, substrate and coenzyme affinities. PMID- 4338809 TI - Sensitization of anoxic mammalian cells to radiation by triacetoneamine-N-oxyl. Effect of pre- and postirradiation treatment. PMID- 4338811 TI - [Nurses' attitude to suicidal patients]. PMID- 4338810 TI - [Treatment of suicidal patients in psychiatric hospitals-clinics]. PMID- 4338812 TI - [Treatment of suicidal patients in outpatient-aftercare departments]. PMID- 4338813 TI - Thymic hormones. PMID- 4338814 TI - Mortality from cholera and other diarrhoeal diseases at a cholera hospital. PMID- 4338815 TI - Viral antibodies among the Turkana people of Northern Kenya. PMID- 4338817 TI - The effect of live infectious bronchitis vaccine on the course of infectious laryngotracheitis. PMID- 4338816 TI - Prevention or cure? Use of toxic herbs and geographic pathology. PMID- 4338819 TI - [Activity of humoral factors on non-specific immunity in infectious hepatitis]. PMID- 4338818 TI - [Morphology of nervous system neoplasms caused by alkylating agents]. PMID- 4338820 TI - Current status of sialography. PMID- 4338821 TI - Femoral neuropathy and anticoagulants. PMID- 4338822 TI - The significance of enzyme histochemical results in different forms of oxygen deficiency. PMID- 4338823 TI - The application of the cytophotometer to the study of metabolic transitions of isolated rat heart. PMID- 4338824 TI - [Methods of prothetic restoration in loss of substance from the palate due to neoplasm exeresis]. PMID- 4338826 TI - DNA synthesis in heterokaryons formed by fusion of mammalian cells from different species. PMID- 4338825 TI - Changes in chromatin caused by aminoazo compounds. PMID- 4338827 TI - [An aggregation phenomenon of lens epithelial cells and the influence of purine derivatives]. PMID- 4338828 TI - Factors affecting acid phosphatase activity in exponential and synchronized L5178Y mouse leukemia cells. PMID- 4338829 TI - Effect of germanium upon development of siliceous spicules of some fresh-water sponges. PMID- 4338831 TI - [Roentgenologic proof of the corpus cavernosum recti]. PMID- 4338830 TI - Inhibition of cell fusion by local anaesthetics and tranquillizers. PMID- 4338832 TI - [Angiography in patients with abdominal murmurs]. PMID- 4338833 TI - [Angiographic studies on portal hypertension in childhood]. PMID- 4338834 TI - [Angiographic diagnosis of renal artery aneurysms]. PMID- 4338835 TI - [The value of isotope functional diagnosis (auto-fluoroscope) as compared with radiographic contrast demonstration of the kidney (vascular diseases and anomalies)]. PMID- 4338836 TI - [99m-Tc-Fe-DTPA--a new complex for renal scanning]. PMID- 4338837 TI - [Ureteral obstruction caused by the ovarian vein as a sequela of pregnancy]. PMID- 4338838 TI - [Effect of Diaphyllin on the angiogram of patients with Raynaud's phenomenon due to vibration]. PMID- 4338839 TI - [Contrast tolerance during angiography, with special reference to blood electrolyte changes]. PMID- 4338840 TI - [Contrast reaction--reaction to anaesthetic?]. PMID- 4338841 TI - [Findings of vertebral angiography in basilar impression]. PMID- 4338842 TI - [Measurements of the lateral phlebogram of carotid arteriograms in the presence of intracranial tumors]. PMID- 4338843 TI - [Pneumo-encephalographic tomography for mid-line intracranial tumours]. PMID- 4338844 TI - [The medichrome method in diagnostic radiology]. PMID- 4338845 TI - [The estimation of scatter during diagnostic radiological procedures using a model]. PMID- 4338846 TI - [Gastric motility during rest and physical stress]. PMID- 4338847 TI - [Calcified heart wall aneurysm]. PMID- 4338848 TI - [Left-sided occlusion of the vena anonyma simulating Paget-von-Schroetter syndrome]. PMID- 4338849 TI - [Angioplasic liver sarcoma in thorotrastosis]. PMID- 4338850 TI - [Arterioportal shunt as complication of a liver tumor]. PMID- 4338851 TI - [Extrahepatically developed liver hemangioma]. PMID- 4338852 TI - [Angiographic demonstration of a malignant islet-cell adenoma]. PMID- 4338853 TI - [Sciatic artery. A rare vessel variant]. PMID- 4338854 TI - [Oxalosis of the kidneys]. PMID- 4338855 TI - [On a case of multiple glomus tumor]. PMID- 4338856 TI - [Neurosurgery in pregnancy. Problems raised by explorations, medical treatments, anesthesia and resuscitation]. PMID- 4338857 TI - [Mulleroblastomas (apropos of 4 cases)]. PMID- 4338858 TI - Oral exfoliative cytology in the diagnosis of viral and bullous lesions. PMID- 4338859 TI - [Concentration of Enteroviruses from water by adsorption on insoluble electrolytes]. PMID- 4338860 TI - Newborn urinary cyclic AMP and developmental renal responsiveness to parathyroid hormone. PMID- 4338861 TI - Babies, hormones and kidneys--a new look at development. PMID- 4338862 TI - [Stability of amphetaminil in watery suspension]. PMID- 4338863 TI - Diurnal cycle and ACTH facilitation of shuttlebox avoidance. PMID- 4338864 TI - Ulceration in the rat's forestomach: its reduction by non-nutritive bulky substances. PMID- 4338865 TI - Neural excitation and sustained sinusoidal acoustic stimulation. PMID- 4338866 TI - The effects of various cure cycles upon the viability of Bacillus subtilis var. niger spores within solid propellant. PMID- 4338869 TI - Three suspected cases of herpes simplex virus encephalitis. PMID- 4338867 TI - Neuroinhibition in the regulation of emesis. PMID- 4338868 TI - Familial Addison's disease. Clinical studies on three cases of the same family. PMID- 4338870 TI - Single-dose and short course regimens of metronidazole in the treatment of amoebiasis in Malaysia. PMID- 4338871 TI - Laboratory evaluation of panidazole (1-(2'-( -pyridyl) ethyl-2-methyl)-5 nitroimidazole), a new amoebicide. PMID- 4338872 TI - Ultrastructure of Iodamoeba butschlii cysts. PMID- 4338873 TI - In vivo distribution and excretion of intravenously injected polyphosphates. PMID- 4338874 TI - Phospholipase A and lysophospholipase activities in isolated fat cells: effect of cyclic 3',5'-AMP. PMID- 4338876 TI - In vitro effects of serum proteins and lipids on lipid synthesis in human skin fibroblasts and leukocytes grown in culture. PMID- 4338875 TI - Some effects of diet on guinea pig serum lipoproteins. PMID- 4338877 TI - Lipid monolayers: surface potential of dipalmitoyllecithin with regard to ion sorption and Ca 2+ binding. PMID- 4338878 TI - The isolation and characterization of plasma membrane from cultured cells. IV. The carbohydrate composition of membranes isolated from oncogenic RNA virus converted chick embryo fibroblasts. PMID- 4338879 TI - Comparative studies on enzyme markers of liver plasma membranes. PMID- 4338880 TI - Characterization of the adenyl cyclase of rat kidney plasma membranes. PMID- 4338881 TI - The interaction of Ricinus communis agglutinin with normal and tumor cell surfaces. PMID- 4338882 TI - Gluconeogenesis in toad urinary bladder. PMID- 4338883 TI - [Changes in manifestations of experimental influenza when combined with para influenza]. PMID- 4338884 TI - [Convergence of signals on motor cortical neurons of the cat under chloralose anesthesia]. PMID- 4338885 TI - [Bone marrow interferon of mice]. PMID- 4338886 TI - [Line of transplantable cells obtained from a transplantable mouse hepatoma]. PMID- 4338887 TI - Ontogeny of bioelectric activity in the spinal cord of the chick embryo and its behavioral implications. PMID- 4338888 TI - The effect of electrical stimulation on the levels of free amino acids and related compounds in the snail brain. PMID- 4338889 TI - The action of selectively activated group II muscle afferent fibers on extensor motoneurons. PMID- 4338890 TI - [Value of a simultaneous association of several therapeutics in pemphigoid Duhring-Brocq disease. Apropos of 22 cases]. PMID- 4338891 TI - Thyrotropin (TSH) response to synthetic TSH-releasing factor following pharmacological blockade of adrenocorticotropin (ACTH) secretion. PMID- 4338893 TI - Synthesis of sucrose and of alpha-D-glucopyranosyl alpha-D-fructofuranoside through the use of 1,3,4,6-tetra-O-benzyl-D-fructofuranose. PMID- 4338892 TI - Determination of inososes with an alkaline solution of copper(II) oxalate tartrate complex (the Somogyi reagent) and reaction mechanisms involved. PMID- 4338894 TI - Polyoma pseudovirions: an experimental model for the development of DNA for gene therapy. PMID- 4338896 TI - Action of angiotensin on vascular adrenergic nerve endings: facilitation of norepinephrine release. PMID- 4338898 TI - [Gestational trophoblastic neoplasms]. PMID- 4338897 TI - Action of angiotensin on adrenergic nerve endings: enhancement of norepinephrine biosynthesis. PMID- 4338900 TI - The effect of media inhomogeneities upon intracranial electrical fields. PMID- 4338899 TI - [Direct breast lymphography--a possibility in the preoperative classification of breast carcinoma]. PMID- 4338895 TI - Actions of angiotensin on the adrenal medulla and autonomic ganglia. PMID- 4338901 TI - A theoretical neural integrator. PMID- 4338903 TI - Stereochemistry of nucleic acids and their constituents. XXVII. The crystal structure of 5'-methyleneadenosine 3',5'-cyclic monophosphonate monohydrate, a biologically active analog of the secondary hormonal messenger cyclic adenosine 3',5-monophosphate. Conformational "rigidity" of the furanose ring in cyclic nucleotides. PMID- 4338902 TI - Central cholinergic mechanism and behavior. PMID- 4338904 TI - The dogfish neuromuscular junction: dual innervation of vertebrate striated muscle fibres? PMID- 4338905 TI - The effect of neuraminidase on the aggregation of BHK21 cells and BHK21 cells transformed by polyoma virus. PMID- 4338906 TI - A clinical evaluation of epicillin (dexacillin) in the treatment of urinary tract infections. PMID- 4338907 TI - [Hepatography with lipiodol during lymphography]. PMID- 4338908 TI - [A new method of lipiodol hepatography using an intraarterial approach]. PMID- 4338909 TI - [Arteriography in liver tumors. Apropos of 39 cases]. PMID- 4338910 TI - [Cyclic AMP and calcium]. PMID- 4338911 TI - [Transport of calcium in the small intestine and active form of vitamin D]. PMID- 4338912 TI - [Proparathyroid hormone]. PMID- 4338913 TI - [Case of vitamin D resistant rickets causing spinal cord compression paralysis in an adult]. PMID- 4338914 TI - [Clinical application of dihydrotachysterol in various types of hypocalcemia]. PMID- 4338915 TI - Release of chylomicrons by isolated cells of rat intestinal mucosa. PMID- 4338917 TI - Properties of ultrasonically irradiated human serum lipoproteins. PMID- 4338916 TI - Biosynthesis of protein relative to the accumulation of fat in the liver of EFA deficient rats. PMID- 4338918 TI - Composition, particle size and role in dietary fat transport of two different lipoproteins of the intestinal lymph. PMID- 4338919 TI - Comparison of dialysis, thin layer and silicic acid column chromatography for prostaglandin isolation from biological material. PMID- 4338921 TI - [New therapeutic approach to the treatment of vitamin D resistant rachitis]. PMID- 4338920 TI - [Hidradenoma papilliferum vulvae--study of ultrastructure]. PMID- 4338922 TI - An early case of linitis plastica. Roentgenographic studies of the mucosa. PMID- 4338923 TI - Indication for surgery in very far advanced carcinoma of the stomach. (Linitis plastica). PMID- 4338924 TI - Active infection with cytomegalovirus and herpes group viruses in children receiving corticosteroid therapy. PMID- 4338925 TI - Pedigree analysis of growth inhibition of rat hepatoma cells, Culb TC, after gamma irradiation. PMID- 4338926 TI - Treatment of inoperable pulmonary tumours with high-energy electrons. PMID- 4338927 TI - Recent advances in the knowledge of Marek's disease. PMID- 4338928 TI - Epiphyseal displacement after metaphyseal fracture in renal osteodystrophy. PMID- 4338929 TI - Excessive development of the frontal bone and frontal sinuses secondary to overlying soft tissue angioma. PMID- 4338930 TI - Immunoglobulin changes in liver disease. PMID- 4338931 TI - Similarity between arthritis virus and Fahey-Crawley virus. PMID- 4338932 TI - Newcastle disease vaccination with beta-propiolactone-inactivated virus given intratracheally. PMID- 4338933 TI - Adenyl cyclase in Dictyostelium discoideum: a possible control element of the chemotactic system. PMID- 4338934 TI - Oxalacetate control of Krebs cycle oxidations in purified plant mitochondria. PMID- 4338935 TI - A possible error during assays for the enzymic phosphorylation of proteins and nucleic acids. PMID- 4338936 TI - The chemical basis for the mutagenicity of hydroxylamine and methoxyamine. PMID- 4338937 TI - Hydralazine-induced disturbances in collagen biosynthesis. PMID- 4338938 TI - Specificity of bacterial collagenase: studies with peptides newly synthesized using the solid-phase method. PMID- 4338939 TI - The interaction of some spin-labeled sulfonamides with bovine erythrocyte carbonic anhydrase B. PMID- 4338941 TI - [Distribution of adenylcyclase activity along the electric organs of Electrophorus electricus (L.)]. PMID- 4338940 TI - [Detection in the anterior lobe of the mammalian hypophysis of cells secreting intermedin using an anti-corticotropin immune serum]. PMID- 4338942 TI - [Effect of angiotensin, vasopressin and cyclic AMP on water and electrolytic transfers in the colic mucosa of the rat]. PMID- 4338943 TI - [Composition of the gases given off by Clostridium septicum, Clostridium chauvoei and Welchia perfringens cultured in a sodium thioglycolate medium under vacuum after alkalinization of the medium at the end of cultivation]. PMID- 4338944 TI - [Immunological study of RNA of the avian myeloblastosis virus]. PMID- 4338946 TI - Comparison of methods for iodinating plasma lipoproteins. PMID- 4338945 TI - Studies on renin. I. Purification of dog renin and micromethod for the determination of renin in dog serum and tissues. PMID- 4338948 TI - Measurement of angiotensin II in blood by radioimmunoassay. PMID- 4338947 TI - Serum lipid screening and typing of hyperlipaemias with special reference to cases with normal to moderately elevated total lipids. PMID- 4338949 TI - [Electro-immunodiffusion of the proteins of the cerebrospinal fluid: determination of 1 -lipoprotein, 1 -E(C'4) and 2 -glycoprotein I]. PMID- 4338950 TI - Antibody responses to herpesviruses (EBV, HSV and CMV) in cancer patients given cultured lymphoblastoid cells. PMID- 4338951 TI - Solubilization of tumour-specific antigen from plasma membrane of an aminoazo-dye induced rat hepatoma. PMID- 4338952 TI - Experimental chronic active hepatitis in rabbits following immunization with human liver proteins. PMID- 4338953 TI - [Physical therapy and pharmacology]. PMID- 4338954 TI - [Discharge coupling and axon motor reflex]. PMID- 4338955 TI - The metabolic fate of (26,27) 3 H-25-hydroxyvitamin d 3 in normal, uremic and rachitic rats. PMID- 4338956 TI - Enzyme response to thyrotoxicosis and hypothyroidism in human liver and muscle: comparative aspects. PMID- 4338957 TI - Nonchromaffin paraganglioma. 3. Glomus jugulare tumors. PMID- 4338958 TI - Carotid body tumor (chemodectoma). PMID- 4338959 TI - Carcinomatous meningitis, with special reference to low chloride concentration in the cerebrospinal fluid. PMID- 4338960 TI - Induction of prophase in interphase nuclei by fusion with metaphase cells. AB - Fusion of an interphase cell with a metaphase cell results in profound changes in the interphase chromatin that have been called "chromosome pulverization" or "premature chromosome condensation" In addition to the usual light microscopy, the nature of the changes has been investigated in the present study with electron microscopy and biochemical techniques Metaphase and interphase cells were mixed and fused at 37 degrees C by means of ultraviolet-inactivated Sendai virus. After cell fusion, morphological changes in interphase nuclei occurred only in binucleate cells which contained one intact set of metaphase chromosomes Irrespective of the nuclear stage at the time of cell fusion, the morphologic changes that occurred 5-20 min later simulated very closely a sequence of events that characterizes the normal G(2)-prophase transition. Radioautography revealed that, late in the process, substantial amounts of RNA and probably protein were transferred from the interphase nucleus into the cytoplasm of fused cells. Thus, the findings indicate the existence in metaphase cells of factor(s) which are capable of initiating biochemical and morphological events in interphase nuclei intrinsic to the normal mitotic process. PMID- 4338961 TI - Colchicine-binding protein and the secretion of thyroid hormone. AB - The role of microtubules in the thyrotropin- or adenosine 3',5' cyclic monophosphate (cyclic AMP)-stimulated accumulation of cytoplasmic colloid droplets and secretion of iodine from the mouse thyroid gland has been investigated by means of different classes of agents that affect the stability of microtubules. The onset of inhibition of secretion by colchicine, the uptake of colchicine-(3)H by thyroid lobes, and the binding of colchicine-(3)H to thyroidal soluble protein are shown to have similar time courses Colloid droplet accumulation is also inhibited and does not readily resume upon removal of colchicine from the medium. This appears to be due to the slow washout of the drug (t((1/2)) approximately hr). Thyroids contain a soluble colchicine-binding protein that resembles microtubule proteins of other tissues with respect to apparent K(m) for colchicine, pH optimum, and stability characteristics Colchicine analogues inhibit iodine secretion and colchicine binding in a parallel manner and as a function of their antimitotic potencies. Microtubule stabilizing agents such as hexylene glycol and D(2)O also inhibit secretion. Thus, inhibition of thyroid secretion by antimitotic agents appears to be mediated by an effect on microtubules. The inhibitory locus of colchicine inhibition occurs after the generation of cyclic AMP, since stimulation of secretion by this nucleotide is blocked by colchicine, whereas thyroid stimulating hormone-induced accumulation of cyclic AMP is not affected. Thus, the functioning microtubule appears to play a role in the induction of colloid endocytosis. PMID- 4338963 TI - The isolation and characterization of mutant strains of the blue-green alga anacystis nidulans. PMID- 4338962 TI - Depletion of vesicles from frog neuromuscular junctions by prolonged tetanic stimulation. AB - Curarized cutaneous pectoris nerve muscle preparations from frogs were subjected to prolonged indirect stimulation at 2/sec while recording from end plate regions. At the ends of the periods of stimulation, the curare was removed and the preparations were fixed for electron microscopy or treated with black widow spider venom to determine the degree to which their stores of transmitter had been depleted. After 6-8 hr of stimulation the nerve terminals were almost completely depleted of their stores of transmitter and of their population of vesicles. Most of the transmitter release occurred during the first 4 hr of stimulation, and after this time most (about 80%) of the fibers were depleted of about 80% of their transmitter. The organization of the nerve terminals in 4-hr preparations appeared normal and the terminals still contained many vesicles. When peroxidase was present in the bathing medium, terminals from stimulated preparations showed many vesicles that contained peroxidase, whereas the rested control preparations showed few such vesicles The fact that after 4 hr the total number of vesicles is not markedly changed while a large fraction (up to 45%) contained peroxidase suggests that in our experiments vesicles were continuously fusing with and reforming from the axolemma. PMID- 4338964 TI - On the role of menaguinone in the reduced nicotinamide adenine dinucleotide oxidative pathway of Bacillus brevis. PMID- 4338966 TI - Pyrrolidonyl peptidase activity: a simple test for differentiating staphylococci. PMID- 4338965 TI - The antigen of Bordetella pertussis that induces bactericidal antibody and its relationship to protection of mice. PMID- 4338967 TI - Haemolymph lipoprotein transport of juvenile hormone. PMID- 4338969 TI - [Concept of abdominal neurosis]. PMID- 4338968 TI - [Alveolar proteinosis]. PMID- 4338970 TI - [Encephalomyelitis--with special reference to viral infection]. PMID- 4338971 TI - [Hereditary muscular dystrophy in the mouse]. PMID- 4338972 TI - [Intramural nerve deficiency]. PMID- 4338973 TI - [Experimental pancreatic tumor]. PMID- 4338974 TI - [Autoimmune hemolytic anemia]. PMID- 4338975 TI - [Tumors with endocrine activities]. PMID- 4338976 TI - [Experimental neurogenic hypertension]. PMID- 4338977 TI - [Marek's disease (lymphomatosis of the chicken) and its virus--comparison with Epstein-Barr virus in man]. PMID- 4338978 TI - [Liver cancer]. PMID- 4338979 TI - Bioassay for -toxin of Clostridium perfrigens using survival time in mice. PMID- 4338981 TI - Immunogenicity of highly purified -toxoid of Clostridium perfringens. PMID- 4338980 TI - A comparison of micromethod and conventional tube method in detection of polio neutralizing antibody. PMID- 4338982 TI - Isolation of bovine papular stomatitis virus from humans. PMID- 4338983 TI - Tetracosactrin in the treatment of rheumatic diseases. PMID- 4338984 TI - Optimal conditions for the assay of lactate dehydrogenase. PMID- 4338985 TI - Stimulation of the medula oblongata of normal and hypertensive rats. PMID- 4338987 TI - [Stevens-Johnson syndrome]. PMID- 4338986 TI - [Effect of angiotensin on cardiac inotropism]. PMID- 4338988 TI - Lipoid cell tumour of the ovary. PMID- 4338989 TI - Fine structure of plant cells infected with bean pod mottle virus. PMID- 4338990 TI - Induction of virus synthesis in polyoma-transformed cells by DNA antimetabolites and by irradiation after pretreatment with 5-bromodeoxyuridine. PMID- 4338991 TI - Common tumor-specific surface antigens on cells of different species transformed by avian RNA tumor viruses. PMID- 4338992 TI - Polyadenylate rich RNA in the 70 S RNA of murine leukemia-sarcoma virus. PMID- 4338993 TI - Complementation of functions required for cell transformation by double infection with RSV mutants. PMID- 4338994 TI - Recovery of the temperature-sensitive mutant of Rous sarcoma virus from chicken cells exposed to DNA extracted from hamster cells transformed by the mutant. PMID- 4338996 TI - Genetic recombination with avian tumor virus. PMID- 4338995 TI - Agglutinability by plant lectins increases after RNA virus transformation. PMID- 4338997 TI - Studies on the relatedness of herpesviruses through DNA-DNA hybridization. PMID- 4338998 TI - [The value of oily lymphography in Hodgkin's disease]. PMID- 4338999 TI - [Evaluation of the consequences of renal ischemia in monoephrectomized animals]. PMID- 4339000 TI - [Renal enzymatic changes during hemorrhagic shock]. PMID- 4339001 TI - Refractoriness of toad bladder to stimulation of sodium transport. PMID- 4339002 TI - Potassium dependence of base-line and ADH-stimulated sodium transport in toad bladder. PMID- 4339003 TI - Kinetics of mitochondrial flavoprotein and pyridine nucleotide in perfused heart. PMID- 4339004 TI - Pulmonary fate of vasoactive peptides in fetal, newborn, and adult sheep. PMID- 4339005 TI - Alterations in the fine structure of the rat epididymis after vasectomy. PMID- 4339006 TI - The influence of some infectious diseases on the conceptus in northern Finland. A study based on routine serological investigation. PMID- 4339007 TI - [Hibernation and hypophyseal corticotropic secretion in the hedgehog (Erinaceus europaeus L.)]. PMID- 4339008 TI - [Cushing's syndrome due to bilateral adrenal hyperplasia and a single secreting adenoma. Nosological discussion]. PMID- 4339009 TI - [Exploration of antehypophyseal insufficiencies with the T.S.H. releasing hormone (TRH)]. PMID- 4339010 TI - [Comparison of biological determination of A.C.T.H. with the clinical, biological and evolutive conditions in 10 cases of Cushing's syndrome]. PMID- 4339012 TI - [Plasmatic ACTH in hypocorticism]. PMID- 4339013 TI - [Treatment of an idiopathic hypoparathyroidism with 25-OH-cholecalciferol]. PMID- 4339011 TI - [Study of hypothalamo-hypophyseal functions in a case of olfacto-genital dysplasia]. PMID- 4339014 TI - LSD and CNS transmission. PMID- 4339015 TI - Adrenergic receptors. PMID- 4339016 TI - The autonomic pharmacology of the bladder. PMID- 4339017 TI - Isolation of acetylcholine receptors. PMID- 4339018 TI - Vasoactive peptides. PMID- 4339019 TI - Chemistry and pharmacology of polypeptide toxins in snake venoms. PMID- 4339020 TI - Effect of hormones on bone development. PMID- 4339022 TI - Use of cytarabine for herpesvirus infections. PMID- 4339021 TI - Pharmacology of the coronary circulation. PMID- 4339024 TI - Acquired hypertrichosis lanuginosa and malignancy. A clinical review and histopathologic evaluation with special attention to the "mantle" hair of Pinkus. PMID- 4339025 TI - [Determination of angiotensinases in plasma]. PMID- 4339023 TI - Macular amyloidosis. PMID- 4339027 TI - Photosensitized reactions in nucleic acids. Photosensitized formation and splitting of pyrimidine dimers. PMID- 4339026 TI - Conflicting results from the oral inoculation of a "cariogenic" streptococcus on caries incidence in the hooded rat. PMID- 4339028 TI - [Urinary elimination of cholecalciferol as sulfate ester in the rat]. PMID- 4339029 TI - Dapsone induced peripheral neuropathy. PMID- 4339030 TI - The role of chalones in epidermal homeostasis. PMID- 4339032 TI - [Particles of a Herpes type from Marek disease in lymphocytes infected and maintained in vitro]. PMID- 4339031 TI - [Activity of microsomal N-acetyl-glucosaminyl-transferases in animal carriers of a Myxovirus infection]. PMID- 4339033 TI - A five-year study of cytomegaloviruria in an adult. PMID- 4339034 TI - Spectral analysis of EEG activity in different sleep stages in normal adults. PMID- 4339036 TI - Phosphatidic acid posphatase activity in hamster lung using an ultrastructural technique. PMID- 4339035 TI - A cytochemical study of the granular pneumonocytes in hamster lung. PMID- 4339037 TI - In vitro culture of periodontal ligament cells. PMID- 4339038 TI - Differentiated function of rat adrenocortical cells in culture. PMID- 4339039 TI - The effects of ethidium bromide on the corticotrophin-induced transformation of mitochondria in rat adrenal cortical cells grown in tissue culture. PMID- 4339040 TI - Corticotrophin release induced by surgical trauma after transection of various afferent nervous pathways to the hypothalamus. PMID- 4339041 TI - Corticotrophin-like peptide concentrations in the intermediate lobe of rat and guinea-pig pituitaries. PMID- 4339042 TI - Glucagon stimulation of the anterior pituitary. PMID- 4339043 TI - Investigation of the hypothalamic-pituitary-adrenal axis in mesomorphic types of pig. PMID- 4339044 TI - Preliminary assessment of a highly sensitive bioassay in vitro for corticotrophin. PMID- 4339046 TI - Plasma cortisol and adrenocorticotrophic hormone in normal non-pregnant individuals and in normal and toxaemic pregnancies. PMID- 4339045 TI - Investigation into effects of corticotrophin given daily to rats over a long period. PMID- 4339047 TI - 17 -Hydroxyprogesterone and testosterone levels in congenital adrenal hyperplasia: effect of treatment with cortisone acetate, dexamethasone and corticotrophin. PMID- 4339048 TI - Intermediary metabolite levels in Escherichia coli. PMID- 4339049 TI - Are plastids derived from prokaryotic micro-organisms? Action of antibiotics on chloroplasts of Euglena gracilis. PMID- 4339050 TI - [Long-term study of insulin secretion in 3 cases of langerhansian adenoma]. PMID- 4339051 TI - [Particles in injectable solutes. 3. Influence of perfusion of massive solutes containing particles of known concentration and diameter, in rabbits]. PMID- 4339053 TI - Human sleep-electroencephalogram: a damped oscillatory phenomenon. PMID- 4339054 TI - Interferon-inducing activity of acidic polysaccharides. II. Induction of rabbit serum interferon by chemically phosphorylated polysaccharides. PMID- 4339052 TI - Potassium activated phosphatase from human red blood cells. The effects of p nitrophenylphosphate on carbon fluxes. AB - 1. When red cells are incubated in solutions containing p-nitrophenyl-phosphate (p-NPP), intracellular p-NPP quickly builds up reaching with a half-time of 3 min a concentration in cell water equal to one fourth the external concentration, which under the conditions used is the expected value for a divalent anion in Gibbs-Donnan equilibrium. Hence p-NPP added to the incubation media in red cells has quick access to the active centre of the membrane phosphatase which is located at the inner surface of the cell membrane.2. When p-NPP is added to the incubation media of ATP-free red cells or reconstituted ghosts, no ouabain sensitive cation movements are detectable, suggesting that hydrolysis of p-NPP by the active transport system is unable to energize active ion translocation.3. When p-NPP concentration in the incubation media of ATP-containing cells is progressively raised, both ouabain-sensitive Na loss and ouabain-sensitive Rb uptake tend to zero along rectangular hyperbolae. For both movements inhibition is half-maximal at 77 mM external p-NPP (i.e. 19 mM internal p-NPP).4. p-NPP inhibits with equal effectiveness the Na:K and the Na:Na exchanges catalysed by the Na pump.5. The inhibitory effect of p-NPP cannot be attributed to the products of its hydrolysis, is inversely related to the intracellular ATP concentration and seems to be exerted at the inner surface of the cell membrane with an apparent affinity similar to that of the membrane phosphatase. These facts suggest that inhibition is mediated by the combination of p-NPP with the active centre of the membrane phosphatase.6. Apart from affecting the ouabain sensitive cation movements, p-NPP increases the ouabain-resistant uptake and loss of both Na and Rb. This effect is about 4 times larger for Rb than for Na, and its kinetic analysis suggests that it is due to an increase in the passive permeability of the cell membrane.7. The increase in passive cation permeability upon addition of p-NPP cannot be attributed to the products of its hydrolysis. It seems to be due to the combination of p-NPP with a site which, like the active centre of the ouabain-resistant membrane phosphatase, faces the inner surface of the cell membrane, is unaffected by ATP and is half saturated by about 15 mM-p NPP. PMID- 4339055 TI - Superinfection of HVJ carrier HeLa cells with ultraviolet-irradiated Newcastle disease virus. PMID- 4339056 TI - Anti-vaccinia activity of -thiochromanone-1-thiosemicarbazone in vitro and in vivo. PMID- 4339057 TI - [Control systems of arterial pressure]. PMID- 4339058 TI - Pediatric vulvovaginitis. PMID- 4339059 TI - Gonadal dysgenesis and its variants. PMID- 4339060 TI - Antibodies produced by immunization of goats with 40S ribosomal subunits from Novikoff hepatoma ascites cells. PMID- 4339061 TI - Inhibition of synthesis of herpes simplex virus deoxyribonucleic acid by a carcinogenic polycyclic aromatic hydrocarbon. PMID- 4339062 TI - Pituitary-adrenal function in photic and olfactory deprived rats. PMID- 4339063 TI - Mouse cytomegalovirus: isolation from spleen and lymph nodes of chronically infected mice. PMID- 4339064 TI - Release of ACTH from isolated pituitary cells: an energy dependent process. PMID- 4339065 TI - Inhibition of RNA virus replication in vitro by 3-deazacytidine and 3 deazauridine. PMID- 4339066 TI - Carcinogenicity of diethylnitrosamine in Mystromys albicaudatus (African white tailed rat). PMID- 4339067 TI - Effects of removal of superior cervical ganglion or auriculotemporal nerve on course of postnatal change in rat parotid amylase. PMID- 4339068 TI - Gazdar strain of murine sarcoma virus. Biologic and antigenic interactions with the heterologous hamster host. PMID- 4339069 TI - Inhibitory effect of carcinogenic aromatic hydrocarbons on transformation of 3T3 cells by SV 40. PMID- 4339070 TI - Reactivation of a bovine herpesvirus after corticosteroid treatment. PMID- 4339071 TI - Increased kidney cyclic AMP levels and erythropoietin production following cobalt administration. PMID- 4339072 TI - [Parinaud's tabetic syndrome]. PMID- 4339073 TI - [2 cases of voluntary paralysis of verticality of gaze in a brother and sister. (Oculographic recordings)]. PMID- 4339074 TI - [Dynamic exploration of carbohydrate metabolism in liver cirrhosis. Determination of free fatty acids and insulin in the blood]. PMID- 4339075 TI - [Fatal anuria after oral cholecystography]. PMID- 4339076 TI - [Gougerot-Sjogren syndrome and glomerulonephritis]. PMID- 4339077 TI - [Radiological interpretation of small hiatal hernias and esophago cardiotuberosity abnormalities]. PMID- 4339078 TI - [Transient deafness and ethacrynic acid. Possible role of the changes in the composition of cochlear fluids]. PMID- 4339079 TI - [Epidemiology of septicemias due to Yersinia enterocolitica]. PMID- 4339080 TI - [Aflatoxicoses]. PMID- 4339082 TI - Response of chicks from vaccinated hens to inoculation with turkey herpes virus. PMID- 4339081 TI - [Maternal infections and pregnancy]. PMID- 4339083 TI - Observations on field trials with an experimental attenuated Marek's disease virus vaccine. PMID- 4339084 TI - Buoyant density of hemagglutinating encephalomyelitis virus of swine: comparison with avian infectious bronchitis virus. PMID- 4339086 TI - Action of cyclic 3':5'-AMP on phosphorylation of uridine in ovariectomised rat uterus. PMID- 4339085 TI - Polynucleotide ligase in mouse cells infected by polyoma virus. PMID- 4339087 TI - [Multiple systemic glomus tumor]. PMID- 4339088 TI - Quantitation of beta lipoprotein cholesterol. PMID- 4339089 TI - Bovine herpesvirus IBR-IPV. Strain differences. PMID- 4339090 TI - A study of weaning, acclimatization, and limited vaccination on the incidence of respiratory disease complex in cattle. PMID- 4339091 TI - [Analysis of the social situation of a group of patients discharged from the neuropsychiatric hospitals in Verona (preliminary note)]. PMID- 4339092 TI - Studies on the circulation of bordetella pertussis and bordetella parapertussis in populations of children. PMID- 4339093 TI - Providencia measuring in a well water sample. PMID- 4339095 TI - [Viral hepatitis--present-day problems]. PMID- 4339094 TI - Study of the distribution of M. para-influenzae in the child population by the serological survey method. PMID- 4339096 TI - Benign lesions of the oral cavity. PMID- 4339097 TI - Ulcerative lesions of the oral cavity. PMID- 4339098 TI - Minor salivary gland tumors of the oral cavity. PMID- 4339099 TI - The poly(dA-dT) of crab. PMID- 4339100 TI - The mechanism of aminoacylation of transfer RNA. PMID- 4339101 TI - [Molecular aspects of leukemogenesis]. PMID- 4339103 TI - [Congenital synovialoma of the knee]. PMID- 4339102 TI - [Relation of the nuclear membrane to cytoplasmic structurs and mechanisms of nuclear-cytoplasmic relations]. PMID- 4339105 TI - Properties of plaque variants of herpes virus hominis strains of genital origin. PMID- 4339104 TI - Fluid therapy in experimental hemorrhagic shock: ultrastructural effects in liver and muscle. PMID- 4339107 TI - System for an early identification of foot-and-mouth disease virus strains. PMID- 4339106 TI - IgM antibodies to Epstein-Barr virus in infectious mononucleosis. PMID- 4339108 TI - Biomathematical system of relationship and dominance for the classification of foot-and-mouth disease strains. PMID- 4339109 TI - Cytomegalovirus infections in organ transplantation and post transfusion. An hypothesis. PMID- 4339110 TI - Scopafungin, an inhibitor of oxidative phosphorylation in mitochondria. PMID- 4339111 TI - Eyes after renal transplantation. PMID- 4339112 TI - Incidence of ocular complications in patients undergoing renal transplantation. AB - The eyes of 39 patients who had received allogenic renal transplants were examined for signs of disease. Nine (23%) had early posterior subcapsular cataracts, two (5%) developed acute cytomegalovirus retinitis, and one developed steroid-induced glaucoma. The lesions which were found were all attributable to the immunosuppressive drug therapy. Thirty-five (87%) had detectable complement fixing antibodies to cytomegalovirus. PMID- 4339113 TI - Adenovirus demonstrated by immunofluorescence. PMID- 4339114 TI - Rickets in Glasgow Pakistanis. PMID- 4339115 TI - Pyridine nucleotide depletion in pancreatic islets associated with streptozotocin induced diabetes. PMID- 4339117 TI - Saccharopine dehydrogenase. Interaction with substrate analogues. PMID- 4339116 TI - Incorporation of 5-iodocytidine into yeast tRNAphe with tRNA nucleotidyl transferase in vitro. PMID- 4339118 TI - The synthesis of D-arabino-hexulosonic acid 6-phosphate and its stability in acid and alkaline medium. PMID- 4339119 TI - The effects of iodate on the blood-vitreous barrier. PMID- 4339120 TI - The mechanism of aqueous outflow in lower mammals. PMID- 4339121 TI - A rare case of Mauriac neuralgic genital herpes. PMID- 4339122 TI - The partial purification from calf serum of a fraction with multiplication stimulating activity for chicken fibroblasts in cell culture and with non suppressible insulin-like activity. PMID- 4339123 TI - The influence of calcium on the cyclic AMP-mediated stimulation of DNA synthesis and cell proliferation by prostaglandin E 1 . PMID- 4339126 TI - Thin-layer chromatography of amino acids with agar-agar as binder. PMID- 4339124 TI - Properties and cellular distribution of cyclic AMP-dependent protein kinase from thymus. PMID- 4339125 TI - Independent regulation of cytochromes and glycolytic enzymes in human fibroblasts. PMID- 4339127 TI - Thin-layer chromatographic separation of conjugated estrogens on silica gel G silver nitrate plates. PMID- 4339128 TI - Adenyl cyclase in normal and psoriatic skin. PMID- 4339129 TI - The cyclic AMP system in normal and psoriatic epidermis. PMID- 4339130 TI - Cell surface alterations in transformed tissue culture cells and their possible significance in growth control. PMID- 4339131 TI - Cellular replication and specialized function of fibroblasts. PMID- 4339133 TI - Tissue compartments of the skin lesion of psoriasis. PMID- 4339132 TI - Controls of connective tissue synthesis: collagen metabolism. PMID- 4339134 TI - Chalone inhibition of cellular proliferation. PMID- 4339135 TI - Control of keratinocyte division in vitro. PMID- 4339137 TI - Effects on transmission through the spinocervical tract evoked from the dorsal columns and the dorsal column nuclei. PMID- 4339136 TI - Studies on the mechanism of action of angiotensin on ion transport by kidney cortex slices. AB - 1. A study has been made of the effects of cyclic AMP, phosphodiesterase inhibitors and protein synthesis inhibitors on the response of rat kidney cortex slices to physiological doses of angiotensin.2. The additions of cyclic AMP, dibutyryl cyclic AMP and/or phosphodiesterase inhibitors to the incubation medium (conditions which would be expected to increase intracellular cyclic AMP levels) were without effect on sodium or potassium transport by kidney slices.3. Actinomycin D (an inhibitor of the transcription stage of protein synthesis), at concentrations which inhibit RNA synthesis by 75%, has no effect on either control or angiotensin stimulated sodium transport.4. Cycloheximide or puromycin (inhibitors of the translation stage of protein synthesis), at concentrations which inhibit protein synthesis by 70-80%, have no effect on control sodium and potassium transport by kidney slices, but completely block the angiotensin stimulation of these processes.5. These findings are discussed in relation to the possible involvement of cyclic AMP and protein synthesis in the mechanism of action of angiotensin on kidney sodium and potassium transport. PMID- 4339139 TI - The effects of bicuculline, picrotoxin and strychnine on neuromuscular inhibition in hermit crabs (Eupagurus bernhardus). PMID- 4339138 TI - The origin of the inhibitory nerve pathway to the rat anococcygeus muscle. PMID- 4339140 TI - Unscientific cultism: "dangerous to your health". PMID- 4339141 TI - [Prophylactic effect of cyclic AMP on alloxan diabetes in mice]. PMID- 4339143 TI - Tetracosactrin in the treatment of rheumatic diseases. PMID- 4339142 TI - [Effect of inosine, NAD and glycine or glucuronic acid lactone on acute toluene or xylene intoxications]. PMID- 4339144 TI - [Feelings of breathlessness]. PMID- 4339146 TI - [Method of infection and pathogenesis of human embryonic virus diseases]. PMID- 4339145 TI - Three-dimensional structure of tRNA. PMID- 4339147 TI - Corticosteroid secretion: responses to alpha1-24 corticotropin, metyrapone and dexamethasone. PMID- 4339148 TI - Phospholipid metabolism in human platelets. PMID- 4339149 TI - [Herpes virus encephalitis in a 3-year-old girl]. PMID- 4339150 TI - [Treatment of gas gangrene]. PMID- 4339151 TI - Effect of syntophyllin and caffeine on the level and uptake of serotonin by thrombocytes and their effect on the inhibition of thrombocyte aggregation. PMID- 4339152 TI - Effect of sodium fluoride on the uptake of serotonin by human thrombocytes and on the aggregation of human thrombocytes. PMID- 4339153 TI - [Clinical psychopharmacology in 1971]. PMID- 4339154 TI - [Radiculography in diagnosis of lumbosciatica (1,330 cases)]. PMID- 4339155 TI - [Aspects of radiculographic diagnosis in lumbago and lumbo-sciatica]. PMID- 4339156 TI - Root decompression as an essential part in lumbosacral fusion-technique. PMID- 4339157 TI - The distribution of osmiophilic lamellae within the alveolar and bronchiolar walls of the mammalian lungs as revealed by osmium-ethanol treatment. PMID- 4339158 TI - Early responses of testicular interstitial cells to stimulation by interstitial cell-stimulating hormone. PMID- 4339159 TI - [The maturation of Coxsackie virus. II. Intervention of a thermorestrictive nucleasic rupture]. PMID- 4339161 TI - [Epidemiology of human tuberculosis in West Africa. Results of five surveys carried out by means of tuberculin tests and random sample in different climatic zones of Upper Volta and the Ivory Coast]. PMID- 4339160 TI - [Study of inclusions produced by "Myxovirus parainfluenzae" 4A and 4B in cultures of Rhesus monkey kidney cells. (Optical microscopy, immunofluorescence and electron microscopy)]. PMID- 4339162 TI - Infected permanent cardiac pacemaker. Management without removal. PMID- 4339163 TI - Membrane phase (transitions) as a diagnostic tool for studying mitochondriogenesis. PMID- 4339164 TI - Evidence for a new biosynthetic pathway of sphingomyelin in SV 40 transformed mouse cells. PMID- 4339165 TI - p-Nitrostyrene: new alkylating agent for sulfhydryl groups in reduced soluble proteins and keratins. PMID- 4339166 TI - Thin-proteolipid films: a new approach to the reconstitution of biological membranes. PMID- 4339167 TI - Role of cyclic 3'5' adenosine monophosphate on corticosteroid synthesis and release from the intact adrenal gland. PMID- 4339168 TI - The effects of alcohols on lipid bilayers: a spin label study. PMID- 4339169 TI - The interrelationship of membrane and protein structure in the functioning of the (Na + = K + )-activated ATPase. PMID- 4339170 TI - Properties of ATPase of gastric mucosa. 3. Distribution of HCO 3 -stimulated ATPase in gastric mucosa. PMID- 4339171 TI - The lipid composition of adult rat brain synaptosomal plasma membranes. PMID- 4339172 TI - [Transfection of hen fibroblasts by denatured deoxyribonucleic acid of transformed Rous cells]. PMID- 4339173 TI - [An intermediary, infectious and transforming DNA of the Rous sarcoma virus in chicken cells transformed by this virus]. PMID- 4339174 TI - [Electron microscope study of the fixation of lectins labelled with Raifort peroxidase on human embryonic cells transformed in vitro by the Rous sarcoma virus (RSV), Bryan strain]. PMID- 4339176 TI - [Contribution to the angiographic diagnostics of tympanojugular chemodectom]. PMID- 4339175 TI - [Cerebral scintigram after administration of 99m Tc pertechnetate]. PMID- 4339177 TI - [The use of radioimmunoassay of angiotensin I and angiotensin II in the diagnostics of renovascular hypertension]. PMID- 4339178 TI - A second polymorphic trait of rabbit serum high density lipoprotein. PMID- 4339179 TI - The treatment of chronic amoebic infection with metronidazole (flagyl). PMID- 4339180 TI - The differential diagnosis of nerve compression syndromes in the arm and hand. The neurologist's approach. PMID- 4339181 TI - Nerve entrapment in the upper limb. PMID- 4339182 TI - Data processing for radial immunodiffusion. PMID- 4339183 TI - Pseudotypes of vesicular stomatitis virus with the coat of murine leukaemia and of avian myeloblastosis viruses. PMID- 4339184 TI - Glycolipid nature of the complement-fixing host cell antigen of vesicular stomatitis virus. PMID- 4339185 TI - Lactobacillus exonuclease mutants. II. Sensitivity toward ultraviolet irradiation and alkylating agents. PMID- 4339186 TI - Synthesis of high-molecular-weight cellular DNA in productive polyoma virus infection. PMID- 4339187 TI - Histidine regulation in Salmonella typhimurium. XI. The percentage of transfer RNA His charged in vivo and its relation to the repression of the histidine operon. PMID- 4339188 TI - Vinblastine and microtubules. II. Characterization of two protein subunits from the isolated crystals. PMID- 4339189 TI - Water of co-ordination in insulin. PMID- 4339190 TI - Structure of DNA in denaturing solvents. I. Bacteriophage PM2 DNA in aqueous sodium perchlorate. PMID- 4339191 TI - Electron paramagnetic resonance probing of macromolecules: a comparison of structure-function relationships in chymotrypsinogen, -chymotrypsin and anhydrochymotrypsin. PMID- 4339192 TI - Rescue of rous sarcoma virus from rous sarcoma virus-transformed mammalian cells. AB - Rat cells transformed by the B77 strain of avian sarcoma virus produce no virus like particles, yet B77 virus was rescued from these cells by Sendai virus mediated fusion with chicken cells. This virus rescue was not affected by treatment of the chicken cells with agents that rendered the cells incapable of dividing, although such treatment greatly reduced the ability of the chicken cells to plate as infectious centers after infection with B77 virus. Fusion of R(B77) cells with chicken erythrocytes also led to virus rescue, although with less efficiency than fusion with chicken fibroblasts. Therefore, virus rescue was probably due to a factor or factors contributed by chicken cells which aid in virus production. PMID- 4339193 TI - Adenovirus-associated virus multiplication. VII. Helper requirement for viral deoxyribonucleic acid and ribonucleic acid synthesis. AB - The adsorption of adenovirus-associated virus (AAV) type 2 by KB cells and the subsequent penetration of the AAV genome to the cell nucleus was measured with and without helper adenovirus type 2 (Ad2). It was found that the helper virus did not enhance either process. On the other hand, a synthesis of AAV deoxyribonucleic acid (DNA) or ribonucleic acid (RNA) was not detected by nucleic acid hybridization after KB cells were infected with AAV type 2 alone, whereas both AAV DNA and RNA synthesis were readily detected when cells were additionally infected with Ad2 or herpes simplex virus type 1, a partial helper of AAV replication. AAV RNA synthesis was initially observed 10 to 11 hr after simultaneous infection with Ad2, but the interval between AAV infection and AAV transcription could be reduced to 4 to 5 hr when cells were first infected with Ad2 for 10 hr. It was estimated that AAV DNA synthesis accounted for 3% of the total DNA in cells after a simultaneous infection with Ad2. These findings, together with the previous observation that adenovirus provides a helper function(s) after AAV uncoating, suggest that AAV are defective only subsequent to the uncoating process, and that helper viruses may provide a factor(s) needed for initiating synthesis of AAV DNA, RNA, or both. PMID- 4339194 TI - Role of subunits of 60 to 70S avian tumor virus ribonucleic acid in its template activity for the viral deoxyribonucleic acid polymerase. AB - Heating the 60 to 70S ribonucleic acid (RNA) of Rous sarcoma virus (RSV) destroys both its subunit structure and its high template activity for RSV deoxyribonucleic acid (DNA) polymerase. In comparative analyses, it was found that the template activity of the RNA has a thermal transition of 70 C, whereas the 60 to 70S structure dissociates into 30 to 40S and several distinct small subunits with a T(m) of 55 C. Analysis by velocity sedimentation and isopycnic centrifugation of the primary DNA product obtained by incubation of 60 to 70S RSV RNA with RSV DNA polymerase indicated that most, but perhaps not all, DNA was linked to small (<10S) RSV RNA primer. Sixty percent of the high template activity of 60 to 70S RSV RNA lost after heat dissociation could be recovered by incubation of the total RNA under annealing conditions. The template activity of purified 30 to 40S subunits isolated from 60 to 70S RSV RNA was not enhanced significantly by annealing. However, in the presence of small (<10S) subunits also isolated from 60 to 70S RNA, the template activity of 30 to 40S RNA subunits was increased to the same level as that of reannealed total 60 to 70S RNA. It was concluded that neither the 30 to 40S subunits nor most of the 4S subunits of 60 to 70S RSV RNA contribute much as primers to the template activity of 60 to 70S RSV RNA. The predominant primer molecule appears to be a minor component of the <10S subunit fraction of 60 to 70S RSV RNA. Its electrophoretic mobility is similar to, and its dissociation temperature from 60 to 70S RSV RNA is higher than that of the bulk of 60 to 70S RSV RNA-associated 4S RNA. The role of primers in DNA synthesis by RSV DNA polymerase is discussed. PMID- 4339196 TI - Properties of somatic cell hybrids between mouse cells and simian virus 40 transformed rat cells. AB - Hybrids between mouse cells and simian virus 40 (SV40)-transformed rat cells were made, and their properties and chromosome constitution were investigated over many generations. Their hybrid nature was confirmed by enzyme studies. During a period of 1 year a loss of 10 to 20% of the total number of chromosomes was observed. The SV40 tumor antigen was present and remained present in the hybrids. The parental and hybrid cells were studied for agglutination with concanavalin A, for growth in soft agar, and for serum requirement. These growth and surface characteristics of the transformed cells appeared in the hybrids. PMID- 4339195 TI - Biosynthetic properties of a polyoma nucleoprotein complex: evidence for replication sites. AB - Under normal growth conditions, all of the newly synthesized polyoma deoxyribonucleic acid (py DNA) that could be extracted from infected mouse cell cultures by the Triton procedure of Green, Miller, and Hendler was in the form of a 55S nucleoprotein complex. Inhibition of protein synthesis by cycloheximide reduced the sedimentation rate of the polyoma complex synthesized during the first hour after addition of the drug to 25 to 35S. Since the 55S and the 25 to 35S complexes each contain closed circular 20S py DNA, it is suggested that the slower complex contains less protein per DNA molecule and that there is normally a small or unstable pool of protein available for binding to newly replicated py DNA. In the presence of cycloheximide, the newly formed 25 to 35S complex was not derived from preexisting 55S complex. Thus, some py DNA which was not solubilized by the Triton method served as a template for replication. Further evidence for the existence of polyoma replication sites is provided by the demonstration that, during the inhibition of protein synthesis, a class of newly replicated py DNA can be solubilized by the sodium dodecyl sulfate procedure of Hirt, but not by the Triton method. It is postulated that continuous protein synthesis is required to release py DNA from replication sites in the form of a Triton-extractable nucleoprotein complex. PMID- 4339198 TI - Cell cycle-dependent activation of rous sarcoma virus-infected stationary chicken cells: avian leukosis virus group-specific antigens and ribonucleic acid. AB - Stationary chicken embryo fibroblasts exposed to Rous sarcoma virus (RSV) remained stably infected for at least 5 days, but they did not release infectious virus or become transformed until after cell division. These infected stationary cells did not contain avian leukosis virus group-specific antigens or ribonucleic acid (RNA) hybridizable to deoxyribonucleic acid (DNA) made by the RSV endogenous RNA-directed DNA polymerase activity. PMID- 4339199 TI - Stability of cytosine-containing deoxyribonucleic acid after infection by certain T4 rII-D deletion mutants. AB - When T-even phage infect Escherichia coli, synthesis of host deoxyribonucleic acid (DNA) rapidly ceases. If the phage carry a mutation in a gene essential for phage DNA synthesis, then the infected bacteria should make no DNA, either host DNA or phage DNA. However, we have found that infection with certain T4 gene 56 (deoxycytidine triphosphatase)-rII double mutants leads to substantial DNA synthesis. Only rII deletion mutations which extend into the middle third of the adjacent, nonessential D region lead to the anomalous DNA synthesis, when combined with a gene 56 mutation; the requirement probably is that the deletion extend into the D2a transcriptional unit identified by Sederoff et al. Genetic evidence indicates that the observed anomalous DNA synthesis is synthesis of phage DNA. We suggest that the D2a region controls, directly or indirectly, a nuclease involved in the breakdown of cytosine-containing DNA. In the absence of the D2a product, the cytosine-containing phage DNA made by the gene 56 mutant is stabilized. PMID- 4339197 TI - Characterization of the polypeptides formed in response to encephalomyocarditis virus ribonucleic acid in a cell-free system from mouse ascites tumor cells. AB - The polypeptide products synthesized at different times in a cell-free system from Krebs mouse ascites tumor cells in response to the addition of encephalomyocarditis (EMC) virus ribonucleic acid (RNA) were characterized by electrophoresis on polyacrylamide gels and fingerprint analysis of their tryptic peptides. Translation of the EMC RNA genome with time occurred in a nonrandom fashion in these systems, to yield products containing sequences characteristic of both virion capsid polypeptides and EMC-specific polypeptides present only in the infected cell. The molecular weights of the products fell in a series from 20,000 to 140,000 daltons, although occasionally traces of larger polypeptides were also observed. All of the major polypeptides appeared to arise from partial or complete translation of about 60% of the EMC RNA genome. They were not formed by cleavage of a large precursor molecule. It is suggested that they are artifacts generated by premature "termination" of nascent polypeptide chains at preferred sites. PMID- 4339200 TI - In vivo and in vitro synthesis of human rhinovirus type 2 ribonucleic acid. AB - HeLa cells infected with human rhinovirus type 2 synthesize a mixture of single and double-stranded ribonucleic acid (RNA). The RNA synthesized by the membrane bound RNA polymerase complex in vitro is also a mixture of single- and double stranded RNA, whereas the deoxycholate-treated RNA polymerase complex synthesized only double-stranded RNA. Although twice as much cell-associated viral RNA is synthesized in vivo at 34 C than at 37 C, there is no difference in the rate of RNA synthesized in vitro at 34 C and 37 C by the polymerase complex. The RNA polymerase complex, after treatment with deoxycholate, sediments as a broad peak with an average sedimentation value of 120S. PMID- 4339202 TI - Tubular cytoplasmic inclusion in dermatomyositis. PMID- 4339203 TI - [Primary liver carcinomas]. PMID- 4339201 TI - Adenovirus-associated virus multiplication. 8. Analysis of in vivo transcription induced by complete or partial helper viruses. AB - We have analyzed ribonucleic acid (RNA) synthesized in KB cells co-infected with adenovirus-associated virus (AAV) type 2 and either adenovirus type 2 (Ad2) or herpes simplex virus type 1 (HSV-1). With either type of helper virus, synthesis of AAV RNA was readily detected by deoxyribonucleic acid (DNA)-RNA hybridization. As is the case for AAV RNA synthesized with helper Ad2, the AAV RNA synthesized with HSV-1 as helper annealed only to the thymidine-rich (minus) AAV DNA strand. In addition, AAV RNA synthesized with either type of helper (i) contained similar nucleotide sequences as determined by hybridization inhibition tests and (ii) had a mean molecular weight of approximately 7.5 x 10(5) based on sedimentation in dimethylsulfoxide-sucrose gradients. These experiments suggest that the restricted helper function of HSV-1 is not due to abnormal transcription of the AAV genome. Since the mean molecular weight of AAV RNA is equivalent to 40 to 50% of the AAV genome, as few as two or three AAV RNA species may be transcribed in vivo. In contrast to adenovirus RNA, cleavage of AAV RNA after transcription was not observed. PMID- 4339204 TI - [Genetics of RNA animal viruses. Temperature-sensitive conditional lethal mutation]. PMID- 4339205 TI - Ultrastructure of adipose tissue in the normal hematopoietic marrow of the rabbit. PMID- 4339206 TI - [Ineffectiveness of rifomycin in the treatment of vaccinia pneumonia in the mouse]. PMID- 4339207 TI - [Presence of alpha-feto-protein during hepatic regeneration after left hepatectomy for hepatoma in a child]. PMID- 4339208 TI - Spontaneous REM behaviors in a microcephalic infant. PMID- 4339209 TI - [Hepatoma with severe hypoglycemic episodes]. PMID- 4339211 TI - The use of the Syrian golden hamster in chronic toxicity testing. PMID- 4339213 TI - Morphologic reflections of viral genome activity in viral oncogenesis of hamsters. PMID- 4339212 TI - Tumors and other lesions induced by murine sarcoma viruses. PMID- 4339214 TI - [Corticotherapy in rheumatoid polyarthritis]. PMID- 4339210 TI - Chemical carcinogenesis in Syrian hamsters. PMID- 4339215 TI - [Electron microscopic observation of cytomegalic inclusion disease]. PMID- 4339216 TI - [Action mechanism of releasing factors]. PMID- 4339217 TI - [Mechanism of action of ACTH]. PMID- 4339218 TI - [TSH and LATS]. PMID- 4339219 TI - [Vasopressin]. PMID- 4339220 TI - [Mechanism of action of parathormone and calcitonin]. PMID- 4339221 TI - [Physiologic role of glucagon--with special reference to its action on the liver]. PMID- 4339222 TI - [Action mechanism of angiotensin]. PMID- 4339224 TI - [Hormone receptors of the liver and fat cells]. PMID- 4339223 TI - [Adrenal cortex hormones]. PMID- 4339225 TI - [Mode of action of cyclic AMP]. PMID- 4339227 TI - [Feedback mechanism in ACTH secretion]. PMID- 4339226 TI - [Problems in cyclic AMP theory]. PMID- 4339228 TI - [Primary osteonecrosis of the knee in the aged. Apropos of 33 cases]. PMID- 4339229 TI - [The role of platelets in the pathogenesis of diabetic retinopathy]. PMID- 4339230 TI - [Scleroderma and alveolar cancer of the lung]. PMID- 4339232 TI - [Rectal lymphography in man. Technic and results in a case of Nicolas-Favre disease and 13 cases of cancer of the rectum]. PMID- 4339231 TI - [Radioclinical semiology of congenital stenosis of the cervical spinal canal]. PMID- 4339233 TI - [Dressler's syndrome relapsing during corticotherapy but cured with immunosuppressive agents]. PMID- 4339235 TI - Ascorbic acid: remission spectrum of L-ascorbic acid dissolved in water admixed barium sulfate and measured on frosted quartz. PMID- 4339234 TI - Formation of cyclic adenosine-3',5'-monophosphate (cyclic AMP) by a crude membraneous fraction of Ehrlich mouse ascites tumour cells. PMID- 4339237 TI - [Value of preparative thin-layer chromatography in the separation and study of the fatty acid composition of various lipid fractions]. PMID- 4339238 TI - [Human cancer antigens]. PMID- 4339239 TI - Natural history of brachial plexus neuropathy. Report on 99 patients. PMID- 4339236 TI - Mandibular growth at puberty. PMID- 4339240 TI - Meclizine and placebo in treating vertigo of vestibular origin. Relative efficacy in a double-blind study. PMID- 4339241 TI - Dapsone-induced peripheral neuropathy. PMID- 4339242 TI - Properties of dephosphorylated s1 -casein. Precipitation by calcium ions and micelle formation. PMID- 4339243 TI - Malate dehydrogenase. X. Fluorescence microtitration studies of D-malate, hydroxymalonate, nicotinamide dinucleotide, and dihydronicotinamide-adenine dinucleotide binding by mitochondrial and supernatant porcine heart enzymes. PMID- 4339244 TI - Phosphorylation of ribosomal proteins of Escherichia coli by protein kinase from rabbit skeletal muscle. PMID- 4339245 TI - Singlet energy-transfer studies on associating protein systems. Distance measurements on trypsin, -chymotrypsin, and their protein inhibitors. PMID- 4339246 TI - Reduction of flavins by molybdenum(V). PMID- 4339247 TI - Subpopulations of human serum very low density lipoproteins. PMID- 4339248 TI - Selective inhibition by glycine of some somatic reflexes in the cat. AB - 1. The effects of intracerebroventricular or intrathecal administration of glycine on some somatic reflexes in chloralosed cats were investigated.2. Glycine produced marked inhibition of the flexor reflex (FR) and crossed extensor reflex (CER) at low doses (2.5-5.0 mg) but even large doses (up to 40.0 mg) had no effect on the facilitation or inhibition of the patellar reflex produced by stimulation of either the reticular formation or the sciatic nerve. The linguomandibular reflex (LMR) could be blocked by 10-20 mg glycine.3. Glycine antagonized strychnine-induced facilitation of FR, CER and LMR and was 5-6 times as active as gamma-aminobutyric acid in this respect.4. The possibility of glycine being a transmitter in spinal pathways is discussed. PMID- 4339249 TI - Effects of a focal penicillin lesion on responses of rabbit cortical neurones to putative neurotransmitters. AB - 1. Epileptogenic foci were generated in rabbit cerebral cortex by the topical application of penicillin.2. Responses to iontophoretically applied putative neurotransmitters were compared in cortical neurones firing spontaneously with those driven by applied excitant substances, both before and after establishing the penicillin focus.3. In the presence of the spiking focus, currents of gamma aminobutyric acid, which normally produced 100% depression of neuronal firing, were ineffective.4. In the same situation, currents of (+/-)-homocysteic acid, glutamate and acetylcholine produced predominantly depolarization block responses, and hence depression of firing.5. It is concluded that an epileptogenic focus can alter the responses of rabbit cortical neurones to microiontophoretically applied neurotransmitter substances. Possible mechanisms for the spread of seizure activity are discussed. PMID- 4339250 TI - Atropine resistant excitation of the urinary bladder: the possibility of transmission via nerves releasing a purine nucleotide. AB - 1. The possibility that a purine nucleotide is involved in excitatory transmission to the urinary bladder has been tested. All the purine compounds tested which contained a pyrophosphate bond produced contraction, adenosine triphosphate (ATP) being the most potent. Adenosine and adenosine monophosphate caused relaxation.2. The response to ATP closely mimicked the nerve-mediated contraction, both being characterized by a rapid contraction which was not maintained. A lack of sensitivity to ATP was noted in some preparations of the rat urinary bladder.3. Both nerve-mediated contractions and contractions caused by ATP were blocked by quinidine, while the response to acetylcholine persisted.4. Nerve-mediated responses were depressed during tachyphylaxis produced by high concentrations of ATP. Tachyphylaxis did not occur when low concentrations were used. Possible explanations for these results are discussed.5. The results are consistent with the hypothesis that non-cholinergic excitatory nerves to the guinea-pig bladder release a purine nucleotide, but do not provide critical evidence for it. PMID- 4339251 TI - Evaluation of mechanisms controlling the release and inactivation of the adrenergic transmitter in the rabbit portal vein and vas deferens. AB - 1. A method is described for the detection and assay of picogramme quantities of noradrenaline. This involves transferring Krebs solution containing noradrenaline to a cascade system where the catecholamine may be bioassayed on superfused preparations of the rabbit aorta and iliac artery.2. Electrical field stimulation of the rabbit vas deferens and portal vein caused the release, into the bathing medium, of a material which was identified by pharmacological and chemical tests as noradrenaline.3. Cocaine (0.3-5 mug/ml) caused a marked increase in noradrenaline output after electrical stimulation of the portal vein and vas deferens. This effect appeared to be maximal at a concentration of 2.4 mug/ml; when the cocaine concentration was increased above 10 mug/ml the noradrenaline output was greatly reduced.4. Phenoxybenzamine (5 mug/ml) caused a 4-8 times greater increase in noradrenaline output than cocaine; however, the increase in output due to phenoxybenzamine was much smaller in tissues pretreated with cocaine.5. Corticosterone (20 mug/ml) increased noradrenaline output by 30-40% in untreated vas deferentia, but caused a 300% increase in output in tissues pretreated with cocaine. Cocaine also caused a much greater increase in output in tissues pretreated with corticosterone than in untreated tissues.6. Treatment with pargyline plus tropolone caused a 100-200% increase in noradrenaline output; this effect was not modified by cocaine, but was abolished when the tissues were pretreated with either phenoxybenzamine or corticosterone.7. When tissues were stimulated for 240 pulses at 1-16 Hz, the output per pulse of noradrenaline increased linearly with the logarithm of the frequency of stimulation. This relationship between frequency and output was seen in both untreated tissues, and in tissues treated with cocaine, phenoxybenzamine, corticosterone or pargyline plus tropolone.8. It is concluded that cocaine enhances output by blocking the neuronal reuptake of noradrenaline, and corticosterone by blocking the extraneuronal uptake and subsequent metabolism of noradrenaline. Phenoxybenzamine acts by blocking both neuronal and extraneuronal uptake mechanisms. There appears to be a dynamic balance in the distribution of noradrenaline between the two uptake mechanisms after the release of the transmission from the nerve endings.9. It is calculated that more than 90% of the noradrenaline released by nerve stimulation (240 pulses at 2-16 Hz) is inactivated by neuronal and extra neuronal uptake mechanisms.10. It is calculated that the fraction of the total noradrenaline store that is released by one pulse at 2 Hz is 6.6 x 10(-5) in the portal vein and 5.6 x 10(-5) in the vas deferens; the corresponding values at 16 Hz were 15.9 x 10(-5) and 16.2 x 10(-5). PMID- 4339252 TI - Salivation induced by prostaglandin F 2 and modification of the response by atropine and physostigmine. AB - 1. Administration of PGF(2alpha) to the anaesthetized dog produced dose-related salivation accompanied by weak pressor and negative cardiac chronotropic effects. Injection of PGE(1) did not produce salivation.2. Electrical stimulation of the chorda tympani nerve or injection of PGF(2alpha) produced salivary responses which were not affected by pretreatment with phentolamine, but were abolished by pretreatment with atropine. Treatment with hexamethonium reduced the response to nerve stimulation but did not alter the response to PGF(2alpha).3. Pretreatment with physostigmine augmented the salivary response to both nerve stimulation and PGF(2alpha).4. These experiments suggest that salivation produced by PGF(2alpha) is probably due in part, to liberation of acetylcholine from cholinergic nerve terminals. These results are consistent with previously proposed modulatory functions of prostaglandins on neurotransmission. PMID- 4339253 TI - Urinary excretion of cyclic AMP and manic-depressive psychosis. PMID- 4339255 TI - Atypical fibrous histiocytoma, malignant fibrous histiocytoma, malignant histiocytoma, and epithelioid sarcoma. A comparative study of 65 tumors. PMID- 4339256 TI - Hepatocellular carcinoma: presentation with vertebral metastases and radicular compression. PMID- 4339254 TI - Endocrine response to substitution of corticotrophin for oral prednisolone in asthmatic children. AB - The hypothalamo-pituitary-adrenal axis has been assessed in 17 asthmatic children before and after long-term prednisolone therapy was changed to daily corticotrophin. In 14 of the 17 children the plasma corticosteroid concentration exceeded 15 mug/100 ml within five days of starting corticotrophin. No exacerbation of asthmatic symptoms occurred during conversion. The plasma corticosteroid response to insulin-induced hypoglycaemia was normal in four children about six weeks after conversion to corticotrophin, took up to 36 months to become normal in nine, and remained abnormal in one child throughout the period of the trial. PMID- 4339257 TI - Basal cell adenoma of minor salivary gland origin. PMID- 4339259 TI - Mixed tumors of salivary glands. Long-term follow-up. PMID- 4339258 TI - Primary colonic plasmacytoma. PMID- 4339261 TI - Occurrence of herpes- and adenovirus antibodies in patients with carcinoma of the cervix uteri. Measurement of antibodies to herpesvirus hominis (types 1 and 2), cytomegalovirus, EB-virus, and adenovirus. PMID- 4339260 TI - Are some human lymphoblastoid cell lines established from leukemic tissues actually derived from normal leukocytes? PMID- 4339263 TI - The synthesis of D-glyceraldehyde-3,3-d 2 3-phosphate. PMID- 4339262 TI - Separation of L-lyxose and some of its furanose derivatives. PMID- 4339264 TI - Two benzylated hydroxyglycals derived from D-fructofuranose. PMID- 4339265 TI - In vitro effect of a variety of biologically active compounds on human cytomegalovirus. PMID- 4339266 TI - Acute renal failure in the rat: protection by passive immunisation against angiotensin II. PMID- 4339267 TI - Chylomicra and very-low density lipoproteins--are they functionally distinct? PMID- 4339269 TI - Sleep associated growth hormone (GH) release and the effect of corticotrophin injections. PMID- 4339268 TI - Effect of phenobarbitone-induction on the excretion of vitamin D metabolites in bile. PMID- 4339270 TI - [Acute inflammation of the marginal periodontium. Cytological characteristics of the acute gingivitis]. PMID- 4339271 TI - Electron microscope and optical diffraction studies on glycerol-extracted insect flight muscle fibres relaxed by pyrophosphate. PMID- 4339272 TI - 3'-5'-cAMP and lysosome membrane labilization. PMID- 4339273 TI - Choline acetyltransferase and acetylcholinesterase in spinal motor neurons cultured in vitro. PMID- 4339274 TI - Studies on the murine L-4946 ascitic leukemia in swiss albino mice. PMID- 4339275 TI - The L-4946 leukemia in the CF 1 mouse. PMID- 4339276 TI - Histochemistry of glutamic-oxaloacetic transaminase in mouse liver during MHV-3 infection. PMID- 4339277 TI - Overcoming of endotoxin--mediated immunosuppression by Bordetella pertussis. PMID- 4339278 TI - The biosynthesis and content of gamma-aminobutyric acid in the goldifsh retina. AB - Goldfish retinas incubated with L-glutamate-(14)C (UL) were found to synthesize gamma-aminobutyric acid-(14)C (GABA-(14)C) The accumulation of newly synthesized GABA was enhanced by physiological stimulation of the retina with flashing light; and this increase was directly proportional to the logarithm of the light intensity. The total GABA content was also higher in light-stimulated than in dark-adapted retinas, although the glutamate content remained unchanged No differences were found in the cell-free activities of glutamate decarboxylase (EC 4 1.1 15) and GABA-glutamate transaminase (EC 2.6.1.19) extracted from light stimulated and dark-adapted retinas. These findings, together with other physiological and morphologcal evidence, suggest that GABA plays a functional role in synaptic transmission in the goldfish retina PMID- 4339279 TI - Direct counting and sizing of mitochondria in solution. AB - Resistive particle counting has been developed for the accurate sizing and counting of mitochondria in solution. The normal detection limit with a 30 micro aperture is 0.48 micro diameter, or 0.056 micro(3) particle volume The mean volume of rat liver mitochondria was 0.42 micro(3) or 0.93 micro in diameter. The average value for numbers of particles per milligram of mitochondrial protein was 4.3 x 10(3), and per gram of rat liver was about 11 x 10(10). These values compare satisfactorily with those derived by light microscopy and electron microscopy. The mean volume for mitochondria from rat heart was 0 60 micro(3) and from rat kidney cortex, 0.23 micro(3). These values agree within 15% of those determined by electron microscopy of whole tissue. Mitochondrial fragility and contaminating subcellular organelles were shown to have little influence on the experimentally determined size distributions The technique may be applied to rapid swelling studies, as well as to estimations of the number and size of mitochondria from animals under different conditions such as liver regeneration and hormonal, pathological, or drug-induced states Mitochondrial DNA, RNA, cytochrome c-oxidase, cytochrome (a / a(3)), and iron were nearly constant per particle over large differences in particle size. Such data may be particularly valuable for biogenesis studies and support the hypothesis that the net amount per particle of certain mitochondrial constituents remains constant during mitochondrial growth and enlargement PMID- 4339280 TI - Serum albumin uptake in isolated perfused renal tubules. Quantitative and electron microscope radioautographic studies in three anatomical segments of the rabbit nephron. AB - Proximal convoluted, proximal straight, and cortical collecting tubular segments isolated from rabbit kidney were perfused with I 125-labeled rabbit serum albumin (RSA-I 125) in ultrafiltrate of serum for up to 3 hr After perfusion, the segments were fixed with glutaraldehyde, embedded in Epon, and either counted with a gamma spectrometer to quantitate protein accumulation or analyzed by electron microscope radioautography to sequentially localize radioactivity Proximal convoluted and proximal straight segments accumulate RSA-I 125 nearly linearly as a function of time whereas cortical collecting segments do not accumulate measurable amounts of protein. The rate of accumulation of RSA-I 125 in the proximal convoluted tubule is 2 6 times as great as that in the proximal straight tubule. Electron microscope radioautography of the isolated proximal tubule demonstrated that RSA-I 125 is taken up via small apical vesicles and tubular invaginations, released into large cytoplasmic vacuoles, and finally concentrated in membrane-bounded structures, some of which are acid phosphatase positive These results show that albumin is absorbed by proximal tubules and may be degraded intracellularly within lysosomes. In addition, less radioactivity was located at all times over the lateral intercellular and basilar labyrinthine spaces, suggesting that labeled albumin and/or its breakdown products may be transported across the peritubular cell membrane. PMID- 4339281 TI - A simple method for the preparation of renal brush borders. PMID- 4339282 TI - Avian adenovirus alone or followed by infectious bronchitis virus in laying hens. PMID- 4339283 TI - Experiments in border disease. VI. Lipid and enzyme histochemistry. PMID- 4339284 TI - [Cyclic idiopathic edema syndrome. II. Radiological study: lymphographic abnormalities]. PMID- 4339285 TI - [Pathological diagnosis of pancreatic cancer]. PMID- 4339286 TI - Composition and concentration of lipoproteins in the serum of normal rats and rats deficient in essential fatty acids. PMID- 4339287 TI - New member on the team. PMID- 4339288 TI - Life outside the hospital. A view from patients and relatives. PMID- 4339290 TI - Kinetic and template studies with 1- -D-arabinofuranosylcytosine 5'-triphosphate and mammalian deoxyribonucleic acid polymerase. PMID- 4339289 TI - Increase of hepatic L-phenylalanine: pyruvate aminotransferase by glucagon in rats. Possible role of adenosine cyclic 3',5'-monophosphate as a mediator. PMID- 4339292 TI - Acute effect of a glucocorticoid on normal human sleep. PMID- 4339291 TI - Inhibition of a cyclic nucleotide phosphodiesterase from beef heart by catecholamines and related compounds. PMID- 4339293 TI - Strain differences in thymus weight in mice with different predispositions to spontaneous mammary cancer. PMID- 4339294 TI - [Early diagnosis of chorion tumors]. PMID- 4339295 TI - [Latent persistent viral infections]. PMID- 4339296 TI - Sebaceous-like cells in the salivary glands and in their tumors. PMID- 4339297 TI - [Experimental studies of oxidation-reduction properties of alpha-lipoic acid]. PMID- 4339298 TI - [Effect of viomycin on the labyrinthine, sensory and retinal chronaxy in subjects with lung tuberculosis]. PMID- 4339300 TI - Colonic neoplasia: a late complication of ureterosigmoidostomy. PMID- 4339299 TI - Clostridial infection in the urinary tract. Report of a case of bladder infection due to Clostridium welchii. PMID- 4339301 TI - Intrarenal thrombosis in a case of carcinoma of the stomach. Radio-renographic findings. PMID- 4339303 TI - [Anesthesia and resuscitation in pheochromocytoma]. PMID- 4339302 TI - Fluorescent modification of adenosine 3',5'-monophosphate: spectroscopic properties and activity in enzyme systems. AB - The synthesis of a highly fluorescent analog of adenosine 3',5'-monophosphate, namely, 1,N(6)-ethenoadenosine 3',5'-monophosphate, has provided a powerful probe for systems involving adenosine 3',5'-monophosphate. The potential utility of this analog is indicated by its long fluorescent lifetime, detectability at low concentration, and relatively long wavelength of excitation (300 nanometers). In protein kinase systems it is a highly acceptable substitute for adenosine 3',5' monophosphate. PMID- 4339304 TI - [Immunologic disturbances during chronic rheumatismal polyarthritis]. PMID- 4339305 TI - [North African splenomegalies. (Apropos of 95 cases observed in the metropolis)]. PMID- 4339306 TI - [Aortic dissecting aneurysm. Apropos of 3 anatomoclinical cases]. PMID- 4339307 TI - [Primacy of preventive medicine]. PMID- 4339308 TI - [Portal hypertension after splenectomy for myeloid splenomegaly]. PMID- 4339309 TI - Lipid metabolism by phagocytes. PMID- 4339310 TI - [Circadian changes of ribosome quantity in liver cells and cells of Yoshida's ascitic hepatoma AH 130]. PMID- 4339311 TI - Ultrastructure of pancreatic acinar parenchyma in acute experimental pancreatitis of the pigeon. PMID- 4339312 TI - The fine structure of mast cells in the tumours of protecting organs of the eye. PMID- 4339313 TI - A case of malignant hepatoma with precocious puberty. PMID- 4339314 TI - Amine precursors, amines, and false neurotransmitters in depressed patients. PMID- 4339315 TI - Community mental health centers: coming to grips with big ideas. PMID- 4339316 TI - Interactions of mineral fiber surfaces with cells in vitro. PMID- 4339317 TI - The pH dependence of the effects of Na + , K + and ouabain on the ATPase activity of NaI-treated brain microsomes with Mg 2+ , Mn 2+ , Ca 2+ and Zn 2+ as divalent metal activators. PMID- 4339319 TI - Influence of pH and cholesterol on the structure of phosphatidylethanolamine multibilayers. PMID- 4339318 TI - Differential effects of digitonin on some enzyme activities of the sodium pump. PMID- 4339320 TI - A study of intact human erythrocytes and their ghosts using stearic acid spin labels. PMID- 4339321 TI - Phenylalanine and methionine transport in Tetrahymena pyriformis. Characteristics of a concentrating, inducible transport system. PMID- 4339322 TI - Characterization of the myoplasma membrane proteins. 3. Gel filtration and immunological characterization of Acholeplasma laidlawii membrane proteins. PMID- 4339323 TI - The effects of lithium on the permeability of an epithelial membrane, the toad urinary bladder. PMID- 4339324 TI - Calcium binding to retinal rod disk membranes. PMID- 4339325 TI - [Further observations on the adaptation to human cells, of a strain of cytomegalic virus from the field-mouse (Apodemus sylvaticus)]. PMID- 4339326 TI - Isoniazid: a review with emphasis on adverse effects. PMID- 4339327 TI - The use of tumors in the analysis of inductive tissue interactions. PMID- 4339328 TI - Cyclic AMP and adrenergic receptor control of rat liver glycogen metabolism. PMID- 4339329 TI - Highly specific testicular adenosine-3', 5'-monophosphate phosphodiesterase associated with sexual maturation. PMID- 4339330 TI - Cyclic AMP-dependent reversible phosphorylation of renal medullary plasma membrane protein. PMID- 4339332 TI - Simultaneous budding of "C-type" particles and rhabdoviruses from individual reptilian cells. PMID- 4339331 TI - Pituitary hormones affecting adrenal 5alpha-reductase activity: ACTH, growth hormone, and prolactin. PMID- 4339333 TI - Dientamoeba fragilis in human feces and bile. PMID- 4339335 TI - Hepatic metabolism of free fatty acids in experimental diabetes. PMID- 4339334 TI - Effect of rifamycin SV hydrazone derivative 18 on the synthesis of EBV-DNA in arginine-deprived Burkitt's lymphoblasts. PMID- 4339336 TI - Integrative action of insulin at the molecular level. PMID- 4339337 TI - Effect of insulin and epinephrine on cyclic AMP-dependent protein kinase in rat diaphragm. PMID- 4339338 TI - On substrate-accelerated death in Klebsiella aerogenes. PMID- 4339339 TI - Heterogeneity of human very low density lipoproteins by gel filtration chromatography. AB - Very low density lipoproteins were separated by gel filtration on Sepharose 4B. A decrease in mean particle diameter and flotation rate was seen with increasing elution volumes. The smaller lipoproteins had relatively more protein and phospholipid and less triglyceride than the larger ones. No differences were noted in the relative contents of the various phospholipids or partial glycerides between small and large lipoproteins. Fatty acid patterns of triglycerides and cholesteryl esters were also similar for the various lipoproteins. Relatively more lecithin containing linoleoyl acyl groups was found in smaller lipoproteins of some subjects. More of the protein of smaller lipoproteins was apo-LDL protein. Apo-HDL peptide was lost from the very low density lipoprotein as a consequence of the gel filtration. PMID- 4339340 TI - Plasma free fatty acid transport during prolonged glucose consumption and its relationship to plasma triglyceride fatty acids in man. AB - Plasma free fatty acid (FFA) transport in human subjects has been studied during the course of prolonged ingestion of different amounts of glucose. Compared with the fasting state, hypocaloric glucose intake resulted in marked suppression of net transport of FFA with no change in (fractional) turnover rate. There was no further suppression of net transport of FFA when the intake was increased to isocaloric or hypercaloric levels, but there was a significant increase in the (fractional) turnover rate, indicating an enhancement of clearance mechanisms. During the 20-24-hr period of fasting after isocaloric glucose consumption, the (fractional) turnover rate quickly fell to that found in the fasting individual, whereas net transport remained suppressed for much longer. This suggested that ingestion of glucose maintains an influence on lipolysis longer than on esterification. During this period of fasting after glucose administration, the contribution of plasma FFA to circulating triglyceride fatty acids increased with time and was positively and significantly correlated with the changes in the net transport of plasma FFA. PMID- 4339342 TI - Determination of acetyl coenzyme A. Interference by a contaminant in malate dehydrogenase. AB - Spectrophotometric determinations of acetyl CoA with malate dehydrogenase and citrate synthase are likely to overestimate the amount of acetyl CoA in solutions containing acetoacetyl CoA, since commercial preparations of malate dehydrogenase may contain thiolase. PMID- 4339341 TI - Influence of dietary fat on the concentration of long-chain unsaturated fatty acid families in rat tissues. AB - The relative concentration of long-chain unsaturated fatty acids (chain length C(20) and greater) of the (n - 6), (n - 7), and (n - 9) families in the cholesteryl esters and phospholipids of rat adrenals, liver, heart, and plasma lipoproteins was measured after the feeding of hydrogenated fat, milk fat, beef tallow, corn oil, and fat-free diets. Barely optimal levels of dietary linoleate were found to result in the same order of concentration of the (n - 6) series of fatty acids as was obtained with excess dietary linoleate. The linoleate-poor or deficient diets-hydrogenated fat and fat-free diets-gave almost identical levels and trends with respect to the concentration of the (n - 9) and (n - 7) series of acids. With these two diets, the concentrations of the total (n - 9) long-chain acids were several times greater than the amounts obtained by feeding either the linoleate-rich diet or the barely linoleate-adequate diets. It is concluded from the results that the linoleate-deficient nature of the hydrogenated fat, rather than its high content of trans acids, would explain the high tendency of this fat to induce the accumulation of long-chain (n - 9) fatty acids in the cholesteryl esters and phospholipids of the tissues studied. PMID- 4339343 TI - Separation of the proteins of egg white and egg yolk and a study of their interactions in whole egg. 3. Amino-acid composition of protein fractions. PMID- 4339345 TI - [Denaturation of canditoxin and phosphatase activation]. PMID- 4339344 TI - Separation of the proteins of egg white and egg yolk and a study of their interactions in whole egg. IV. Electrophoretic studies. PMID- 4339346 TI - [Rapid sleep and ocular movements. A new peculiar aspect of sleep polygraphic recording]. PMID- 4339348 TI - Case report: removal of Wilm's tumour. PMID- 4339347 TI - [Virus infections. Diffusion and epidemiology]. PMID- 4339349 TI - [Paget's carcinoma of the male mammary gland]. PMID- 4339350 TI - Giant axonal neuropathy. PMID- 4339351 TI - [Pathogenic mechanisms in renal hypertension]. PMID- 4339352 TI - Improved technique for radioimmunoassay of angiotensin II in plasma. PMID- 4339354 TI - Daily variation in concentration of cortisol in plasma in intact and hypophysectomized gulf killifish. AB - A daily variation in concentration of cortisol in plasma is synchronized by a 12 hour daily photoperiod in intact as well as in hypophysectomized fish. The daily rhythm in concentration of the adrenal steroid does not depend on a daily rhythm in the concentration of pituitary adrenocorticotropic hormone. PMID- 4339353 TI - Pitting function of the spleen in malaria: ultrastructural observations. AB - Ultrastructural studies of spleens from monkeys infected with Plasmodium knowlesi suggest that the spleen removes or "pits" malaria parasites from red cells. This function may explain the presence of nonparasitized spherocytic erythrocytes in the peripheral blood and may in part account for the discrepancy between the excessive hemolysis and the number of parasitized erythrocytes in animals with experimentally induced malaria. PMID- 4339355 TI - [Value of anticoagulant treatment during acute respiratory insufficiency attacks]. PMID- 4339356 TI - [Condylomatous form of Bowen's disease of the vulva]. PMID- 4339357 TI - [Obstructive cardiomyopathy and arterial hypertension. Apropos of 10 cases]. PMID- 4339358 TI - [Genetic counseling]. PMID- 4339359 TI - [Use of I 131 iodoquine in the diagnosis of lymph-node metastasis of a naevocarcinoma]. PMID- 4339360 TI - [Spleen and hemolysis]. PMID- 4339361 TI - The reversibility of increased rat liver weights and microsomal processing enzymes after feeding high levels of 2,2,4-trimethyl-1,3-pentanediol diisobutyrate. PMID- 4339362 TI - Pseudo-vitamin D deficiency rickets: a case report. PMID- 4339363 TI - Characterisation of a viral agent resembling bovine herpes mammillitis virus. PMID- 4339364 TI - [Glomus jugulare tumor: anatomoclinical study of 3 cases]. PMID- 4339365 TI - Cytomegalovirus infection anong infants admitted to a paediatric department. PMID- 4339366 TI - Ketotic hypoglycemia in a four-year-old boy with adrenal cortical insufficiency. PMID- 4339367 TI - Base analysis of ribopolynucleotides by chemical tritium labeling: a methodological study with model nucleosides and purified tRNA species. PMID- 4339368 TI - Effect of sucrose on continuous-flow analyzers. PMID- 4339369 TI - Electrophoretic characterization of ATP-sulfate adenylytransferase (ATP sulfurylase) using acrylamide gels. PMID- 4339370 TI - Interaction of Ca 2+ with endoplasmic reticulum of rat liver: a standardized procedure for the isolation of rat liver microsomes. PMID- 4339371 TI - Succinyl derivatives of adenosine 3',5'-cyclic monophosphate: synthesis and purification. PMID- 4339372 TI - Radial diffusion in gel for micro determination of enzymes. II. Plasminogen activator, elastase, and nonspecific proteases. PMID- 4339373 TI - [Psychophysiology of sleep]. PMID- 4339374 TI - [The function of paradoxical sleep: facts and theories]. PMID- 4339375 TI - [Changes of enzyme activities in the subepiphyseal tibial spongiosa of rats under parathyroid hormone effect]. PMID- 4339376 TI - [Congenital tibial pseudarthrosis from the biochemical viewpoint]. PMID- 4339377 TI - A search for esters of fatty acids and short-chain primary alcohols in human adipose tissue. PMID- 4339378 TI - Acetylcholine stimulation on phosphatidylinositolinositol phosphohydrolase of rat brain cortex. PMID- 4339379 TI - "Phospholipid effect" and secretion in the rat pancreas. PMID- 4339380 TI - The identification of large amounts of cerebroside and cholesterol sulfate in the sea star, Asterias rubens. PMID- 4339381 TI - Serum lipoproteins of the Pacific sardine (Sardinops caerulea Girard). PMID- 4339383 TI - A possible relation between phosphoinositides and the diglyceride pool in rat brain. PMID- 4339382 TI - Soluble and particulate forms of phosphoinositide phosphodiesterase in ox brain. PMID- 4339384 TI - Catabolism of human very-low-density lipoproteins in monkeys: the appearance of human very-low-density lipoprotein peptides in monkey high-density lipoproteins. PMID- 4339385 TI - Role of the -adrenoceptor in regulating noradrenaline overflow by nerve stimulation. AB - 1. A study of the actions of phenoxybenzamine on transmitter overflow, neuronal and extraneuronal uptake of noradrenaline and in causing alpha-adrenoceptor blockade was carried out using the isolated cat nictitating membrane preparation.2. Phenoxybenzamine increased transmitter overflow elicited by nerve stimulation at 10 Hz in a concentration dependent manner in the range 10(-8) to 10(-5) g/ml.3. Neuronal uptake of [(3)H]-noradrenaline was not inhibited by concentrations lower than 10(-6) g/ml of phenoxybenzamine. With 10(-7) g/ml of phenoxybenzamine a significant increase in transmitter overflow was obtained, although neuronal uptake of noradrenaline was not affected. Higher concentrations of phenoxybenzamine (10(-6) and 10(-5) g/ml) inhibited the neuronal uptake of noradrenaline and further increased transmitter overflow.4. Extraneuronal uptake of [(3)H]-noradrenaline was inhibited only with the highest concentration of phenoxybenzamine tested (10(-5) g/ml) and therefore appears to be unrelated to the effects on transmitter overflow.5. There was a significant correlation between the degree of alpha-adrenoceptor block produced by phenoxybenzamine and the increase in transmitter overflow obtained by nerve stimulation.6. These results indicate that phenoxybenzamine, in addition to increasing overflow by preventing reuptake of noradrenaline, may increase transmitter release.7. The possibility that phenoxybenzamine acts on alpha-adrenoceptors in the adrenergic nerve terminal is discussed. These receptors would be involved in a negative feedback mechanism regulating transmitter release. PMID- 4339386 TI - The actions of prostaglandins E 1 and F 2 on the on the perfused vessels of the isolated rabbit ear. AB - 1. In the isolated rabbit ear vascular bed, perfused with Krebs solution, prostaglandins E(1) and F(2alpha) produce dose-dependent, phentolamine-sensitive constrictions.2. These are absent if the animal is pre-treated with reserpine or if the ear is denervated in advance.3. If noradrenaline or vasopressin is added to the Krebs solution, vascular resistance is high and PGE(1) and PGF(2alpha) produce vasodilatation which is unaffected by hyoscine or propranolol.4. Perfusion with theophylline, with added ATP, ADP or 3'5'-AMP, or pre-treatment of the animal with stilboestrol antagonizes the dilator response to PGE(1) in the presence of noradrenaline, which may be reversed. Most of the responses to PGF(2alpha) are reversed. These treatments elevate the level of 3'5'-AMP in tissues.5. It is postulated that prostaglandins exert a regulatory action on 3'5' AMP levels through inhibition of adenyl cyclase and/or phosphodiesterase and that the resulting rising or falling level of 3'5'-AMP determines the nature of the response by the smooth muscle to the released noradrenaline. PMID- 4339387 TI - Action of some bisquaternary derivatives of phthalic acids and related substances on neuromuscular transmission. AB - 1. All the bisquaternary derivatives of terephthalic acid with three methyl groups on each nitrogen atom (PK-107, PK-95, PK-97 and PK-126) were depolarizing neuromuscular blocking agents. The most active was the compound PK-97, in which the two quaternary groups are separated by sixteen atoms and are about 20 A (2 nm) apart. Activity was reduced many fold either by decreasing the separation to twelve atoms or by increasing it to eighteen atoms. It was also reduced several hundred fold when one trimethylammonium group in PK-97 was replaced by a hydrogen atom (as in PK-119).2. The presence and position of the ester groups in these compounds is important; depolarizing activity is in most cases greatest when the ester groups are the same distance from the quaternary nitrogen atoms as in acetylcholine, that is, in carbolonium, sebacoyldicholine and PK-154. The monoquaternary analogues of carbolonium and sebacoyldicholine are appreciably active, having between about one-tenth to one-fifth of the activity of their bisquaternary analogues.3. The relationships between the structure and activity of these compounds are discussed, particular consideration being given to the structure of the chain separating the quaternary groups and the arrangement of acetylcholine receptors on cells and of esterbinding groups within these receptors. PMID- 4339389 TI - Effects of frusemide on cyclic AMP binding in the toad bladder. PMID- 4339388 TI - The central action of clonidine and its antagonism. AB - 1. We have examined the central actions of clonidine (2-(2-6-dichlorphenylamine) 2-imidazoline hydrochloride). It has been confirmed that when infused into the vertebral artery at 2 mug/min, it caused a decrease in blood pressure and a slight increase in heart rate. The same dose given intravenously or into the carotid artery had no effect.2. Intravertebral clonidine also greatly reduced the reflex response to carotid occlusion and the effects of an intravertebral infusion of angiotensin (1 ng/kg)/min.3. This central action of clonidine was antagonized by the adrenergic neurone blocking drug bethanidine (4-5 mg/kg intravenously) even after the cervical cord had been transected at C(4)-C(6) suggesting that bethanidine also has central actions.4. Other drugs which also antagonized the central effects of clonidine were guanethidine (4-5 mg/kg intravenously), bretylium (10 mg/kg intravenously) and phentolamine (0.2 mg/kg intravenously).5. It is suggested that there are central adrenergic neurones which inhibit cardiovascular autonomic reflexes and that the central autonomic effects of clonidine are due to stimulation of inhibitory adrenoceptors. The antagonism by adrenergic neurone blocking drugs of the effect of clonidine could therefore be due to blockade of these inhibitory pathways.6. The central action of clonidine could only be demonstrated when a high concentration was infused into the vertebral artery and could not be shown with oral doses of (20 mug/kg)/day for seven days. It is concluded that the hypotensive action of therapeutic doses is unlikely to be due to the central action of clonidine. PMID- 4339390 TI - Comparison of the phosphodiesterases in the submaxillary gland, brain and liver. PMID- 4339391 TI - Inhibition of prostaglandin synthesis and functional hyperaemia in rabbit adipose tissue. PMID- 4339392 TI - Transmission from intramural inhibitory neurones to circular smooth muscle of the rabbit caecum and the effects of catecholamines. PMID- 4339393 TI - A preliminary investigation into the metabolic requirements of the contractile response of guinea-pig ileum to angiotensin. PMID- 4339394 TI - Degradation of angiotensin II by plasmin. AB - 1. Synthetic angiotensin II (Hypertensin, Ciba, Basel) was incubated with a water insoluble preparation of plasmin (E.C. 3.4.4.14) and the resulting products analysed by paper chromatography and N-terminal amino-acid analysis.2. Only the N terminal asparagine was split off from the peptide. This indicates that plasmin attacks the Asn-Arg but not the Arg-Val in angiotensin II molecule. PMID- 4339395 TI - Mechanisms by which human blood platelets accumulate glycine, gaba and amino acid precursors of putative neurotransmitters. AB - 1. We have examined the accumulation by human blood platelets of amino acids that are believed to be involved in neurohumoral transmission in the central nervous system.2. Platelets were incubated in Ca(++)-free Krebs solution at 37 degrees C with radio-active amino acids for various times and then the platelets were analysed for the radioactive substance and its metabolites.3. L-Phenylalanine, L DOPA, L-tryptophan and L-tyrosine were rapidly accumulated, the equilibrium tissue/medium concentration ratio (C(i)/C(0)) being greater than 10:1 when the concentration of amino acid in the medium was 10(-7)M or lower. Glycine and gamma aminobutyric acid (GABA) accumulation was less, C(i)/C(0) being lower than 3:1 when C(0) was 10(-7)M.4. Uptake of L-phenylalanine, L-DOPA and L-tryptophan were all decreased or abolished by incubation at 4 degrees C, or with metabolic inhibitors or by disruption of the platelet membrane prior to incubation, while L tyrosine accumulation was not affected.5. It is considered that L-phenylalanine, L-DOPA and L-tryptophan are accumulated by saturable, energy-dependent processes; that glycine and GABA diffuse into the platelet, and L-tyrosine accumulates as a result of diffusion and intracellular binding.6. None of the amino acids examined showed any significant metabolism during a 20 min incubation. However, some evidence for tyrosine binding to soluble protein was obtained.7. Results are compared to reports of accumulation of these amino acids by the central nervous system. PMID- 4339396 TI - Analyses of the urethral pressure profile by means of electromyography and the administration of drugs. PMID- 4339397 TI - [Intracranial glioma in the black African]. PMID- 4339399 TI - [Bile-secreting cranial metastasis revealing an undiscovered primary liver cancer]. PMID- 4339398 TI - [Various determinations of the constituents of amniotic fluid of African women in Dakar]. PMID- 4339400 TI - [Glomus jugulare tumor (a case)]. PMID- 4339402 TI - [Estradiol, cyclic AMP, acid nuclear proteins and nucleoplasmic RNA polymerase in heifer endometrium]. PMID- 4339401 TI - [Cornea and Armstrong's virus. Apropos of a case of recurrent epithelial keratitis]. PMID- 4339403 TI - The mechanism of action of aflatoxin B 1 ; observations on virus-infected cells. PMID- 4339404 TI - Concentration effect of bisulfite on the inactivation of transforming activity of DNA. PMID- 4339405 TI - Chemical aspect of penicillin allergy: imidazole-catalyzed isomerization of benzylpenicillin into benzylpenicillenic acid. PMID- 4339406 TI - [Studies on lymphocyte transformation in recurrent aphthae]. PMID- 4339407 TI - [Prosthetic treatment of partial and total anodontia in childhood]. PMID- 4339408 TI - [The use of terracortril in the conservative treatment of acute periapical inflammations]. PMID- 4339409 TI - [Biological properties of human placental lactogen (HPL; human chorionic somatomammotropin)]. PMID- 4339410 TI - Properties of an SV40-transformed African green monkey kidney (BSC-1) cell line. PMID- 4339411 TI - The formation of variants with a reversion of properties of transformed cells. VI. Stability of the reverted state. PMID- 4339412 TI - EB-virus associated serology in malignant disease: antibody levels to viral capsid antigens (VCA), membrane antigens (MA) and early antigens(EA) in patients with various neoplastic conditions. PMID- 4339414 TI - Rescue of the genome of the defective murine sarcoma virus from a non-producer hamster tumor cell line, PM-1, with murine and feline leukemia viruses as helpers. PMID- 4339413 TI - [Immunochemical and immunological study of human brain tumors]. PMID- 4339415 TI - Progestin secretion in 3-methylcholanthrene-treated rats. PMID- 4339416 TI - In vitro study of cellular immunity against autochthonous human cancer. PMID- 4339417 TI - Tumors of the lower extremities. PMID- 4339418 TI - [Symposium; nervous system diseases and metabolism]. PMID- 4339419 TI - Granular cell myoblastoma of the larynx. PMID- 4339420 TI - [The relationships between the adrenal medulla and cortex. A study of the hormonal secretions of the regenerated adrenal gland after neonatal autograft in the rat]. PMID- 4339421 TI - [Study on the change of the serum lipids and lipoproteins in patients with arteriosclerosis due to aging]. PMID- 4339422 TI - Fingerprint body myopathy, a newly recognized congenital muscle disease. PMID- 4339424 TI - Nightmare behavior: a review. PMID- 4339423 TI - Low renin hypertension and the adrenal cortex. PMID- 4339425 TI - Inhibition of chemical carcinogenesis by viral vaccines. AB - The incidence of 3-methylcholanthrene-induced subcutaneous tumors was significantly reduced by a single injection of inactivated type C RNA viral vaccine. Rauscher leukemia virus vaccine reduced the incidence of sarcomas from 78 to 50 percent in the BALB/cCr mouse. Radiation leukemia virus vaccine and a vaccine from a wild murine leukemia virus derived from a 3-methylcholanthrene tumor reduced the incidence of sarcoma from 86 percent to 33 and 37 percents, respectively, in the C57BL/6 mouse. These reductions in tumor incidence by virus vaccines help support the concept that type C RNA viruses serve as determinants of chemically induced cancer; additional studies of vaccines made with more purified virus preparations are necessary. PMID- 4339426 TI - Collagenase: localization in polymorphonuclear leukocyte granules in the rabbit. AB - Polymorphonuclear leukocyte granules were submitted to zonal fractionation through a discontinuous sucrose gradient. Azurophilic and specific granules were enzymatically characterized by peroxidase and alkaline phosphatase activity, respectively. The enzymes formed modal distributions like those reported by others. Collagenase activity was consistently associated with the specific granules containing alkaline phosphatase. PMID- 4339427 TI - Yellow fever vaccination, avian leukosis virus, and cancer risk in man. AB - Comparison was made between 2659 veterans who died of cancer, during 1950 to 1954 or 1959 to 1963, and matched controls, based on the frequency of yellow fever immunization during World War II. The vaccine was produced from chick embryos that almost certainly contained avian leukosis-sarcoma viruses. Among the veterans, no relation was found between vaccination and leukemia, lymphoma, or other cancer. PMID- 4339428 TI - Infective agents and embryopathy in the west of Scotland 1966-1970. PMID- 4339429 TI - [Antagonism and competition between Parkinson's syndrome and the chorea and athetosis syndrome. Clinical cases of the association (including an anatomoclinical case). The abnormal movements provoked by levodopa in Parkinsonian patients]. PMID- 4339432 TI - [Non-atheromatous intimal stenosis of the renal artery. Reflections apropos of a case]. PMID- 4339431 TI - [Double-blind study of the action of sulpyride in post-concussion vertigo states due to cranial injuries. Objective elements]. PMID- 4339430 TI - [Pleural effusion in liver cirrhosis]. PMID- 4339433 TI - [Dynamic exploration of alcohol ingestion in alcoholics with mental diseases]. PMID- 4339434 TI - [Variations of postural tonic activity as a function of alcoholic intoxication]. PMID- 4339435 TI - [Study of diuresis in alcoholics with mental disorders]. PMID- 4339436 TI - [Clinical and therapeutic aspects of psychiatric alcoholism]. PMID- 4339438 TI - [Study of several psychometric aspects of mental deterioration in chronic alcoholics]. PMID- 4339437 TI - [Effects of alcoholic intoxication on the visual apparatus]. PMID- 4339439 TI - [Jean Lenegre, 1904-1972]. PMID- 4339440 TI - [Results of a mass screening of diabetics]. PMID- 4339441 TI - [The pathological role of the lymphatic vessels of nerves]. PMID- 4339442 TI - [Hand-Schuller-Christian disease and histiocytosis. X. (Apropos of a case with double diabetes)]. PMID- 4339444 TI - [Experimental research on the absence of addictive properties of a psychoactive drug: sulpyride]. PMID- 4339445 TI - [Myeloid leukemoid reaction in cancer of the pancreas: paraneoplastic syndrome or myeloid leukosis?]. PMID- 4339443 TI - [Research on blood lipid changes during hydrotherapy with sodium bicarbonate]. PMID- 4339446 TI - [Lichen planus, an often unrecognized dermatosis]. PMID- 4339447 TI - [Results of the routine search for diabetes in the occupational environment]. PMID- 4339448 TI - The effect of a rabbit ACTH preparation on adrenal steroid biosynthesis. PMID- 4339449 TI - [Anatomo-clinical criteria of malignancy in the mixed tumors of the parotid]. PMID- 4339451 TI - [Investigation of taste buds of barbels of Corydoras paletus Jenyus. I. Ultrastructure of the taste buds]. PMID- 4339452 TI - Pigmented villonodular synovitis of the hip-joint. PMID- 4339453 TI - Isolation of Herpesvirus hominis from Lemurs: a naturally occurring epizootic at a zoological garden in Nigeria. PMID- 4339454 TI - Platelets and thrombogenesis--current concepts. PMID- 4339455 TI - The EMC virus in valves of the heart. PMID- 4339456 TI - Sleep in the burrowing owl (Speotyto cunicularia hypugaea). PMID- 4339457 TI - Sleep in the domestic pigeon (Columba livia). PMID- 4339458 TI - Arousal threshold in the rat determined by "meaningful" stimuli. PMID- 4339460 TI - Depression of DNA polymerase activity in chromatin by incubation with NAD. PMID- 4339459 TI - Some mutants of Bacillus brevis deficient in gramicidin S formation. PMID- 4339461 TI - Identification of the 3' 5' - cyclic AMP phosphodiesterase inhibitor in potato: feed-back control by inorganic phosphate. PMID- 4339463 TI - Modification and introduction of a specific radioactive label into the erythrocyte membrane sialoglycoproteins. PMID- 4339462 TI - Effect of cytochalasin B and colchicine on the stimulation of -amylase release from rat parotid tissue slices. PMID- 4339464 TI - Ganglioside biosynthesis in mouse cells: glycosyltransferase activities in normal and virally-transformed lines. PMID- 4339465 TI - Inhibition of rat citrate synthase by acetoacetyl CoA and NADH. PMID- 4339466 TI - Inhibition of adenosine deaminase by alcohols derived from adenine nucleosides. PMID- 4339467 TI - Separation of a cyclic 3',5'-adenosine monophosphate binding protein from yeast. PMID- 4339468 TI - Content of cyclic 3',5'-adenosine monophosphate and adenylyl cyclase in yeast at various growth conditions. PMID- 4339469 TI - General kinetic mechanism of microsomal carbamyl phosphate: glucose phosphotransferase, glucose 6-phosphatase, and other associated activities. PMID- 4339470 TI - -Fluoroadenosine triphosphate. Synthesis, properties, and interaction with myosin and heavy meromyosin. PMID- 4339471 TI - 13 C and 1 H nuclear magnetic resonance relaxation measurements of the lipids of sarcoplasmic reticulum membranes. PMID- 4339472 TI - Premelting unwinding of the deoxyribonucleic acid duplex by aqueous magnesium perchlorate. PMID- 4339473 TI - Urea denaturation of active-site spin-labeled -chymotrypsin. PMID- 4339474 TI - Effect of adenosine di- and triphosphates on the stability of synthetic myosin filaments. PMID- 4339475 TI - Salt effects on histone IV conformation. PMID- 4339477 TI - Reaction of N-bromosuccinimide with reduced ring systems. Apparent protection of glutamate dehydrogenase by reduced nicotinamide-adenine dinucleotide. PMID- 4339476 TI - Angiotensin I converting enzyme of calf lung. Method of assay and partial purification. PMID- 4339479 TI - Membrane intercalated particles: the plasma membrane as a planar fluid domain. PMID- 4339478 TI - Purification of hepatic microsomal membranes. PMID- 4339480 TI - The molecular basis of fluidity in membranes. PMID- 4339481 TI - Spin labels in membranes. PMID- 4339482 TI - Erythrocyte membranes--some effects on sonication. PMID- 4339483 TI - Role of membranes in effector systems for hormone and drug action. PMID- 4339484 TI - What pediatricians should know about malabsorption, but are afraid to ask. PMID- 4339485 TI - [Effect of denaturating agents on the EPR signal parameters of copper-containing protein from erythrocytes]. PMID- 4339486 TI - Cardiovascular and renal effects of acute administration of a new hypotensive compound, guancydine. PMID- 4339487 TI - [Carcinoma in post-tuberculous scars in the lung]. PMID- 4339488 TI - Preliminary observations on a glucose-6-phosphate-hydrolyzing enzyme in secretory cells: a light microscopic study. PMID- 4339489 TI - On the specificity of a histochemical method for localizing dihydrofolate dehydrogenase. PMID- 4339490 TI - Ultrastructure of the alimentary tract of Aspidogaster conchicola (Trematoda: Aspidogastrea). PMID- 4339491 TI - Ultrastructural phosphohydrolase activities in Schistosoma mansoni sporocysts and cercariae. PMID- 4339492 TI - Eimeria tenella in monoflora and diflora chicks. PMID- 4339493 TI - Hypoderma lineatum (De Vill.) (Diptera: Oestridae): invasion of the bovine skin by newly hatched larvae. PMID- 4339494 TI - [Survival and physiological activity of yeast strains following prolonged storage in silica gel]. PMID- 4339495 TI - [Study of the germination of Actinomyces streptomycini B-6 spores by the hydrophobic spin-probe method]. PMID- 4339496 TI - [Field observations concerning airborne transmission of foot-and-mouth disease virus]. PMID- 4339497 TI - [Puncture-biopsy of the vertebral body]. PMID- 4339498 TI - [Ischemic colitis (Marston type). Anatomo-pathological study of 6 cases]. PMID- 4339499 TI - [Emergency esophageal and gastric fibroscopy in 150 cases of upper digestive tract hemorrhage]. PMID- 4339501 TI - [Giant cell arteritis and rheumatism]. PMID- 4339500 TI - [Tuberculosis of the cranial vault]. PMID- 4339502 TI - [Cardiac lung, this unknown disease]. PMID- 4339503 TI - [Permanent work disability in social security. (Report of the Audit Office)]. PMID- 4339504 TI - [Reasons for late diagnosis of stomach cancer]. PMID- 4339505 TI - [Rheumatoid arthritis: treatment in 1972]. PMID- 4339506 TI - Collagen formation--observations on its intracellular packaging and transport. PMID- 4339507 TI - [Immunofluorescence demonstration of glycoproteic hormone producing cells in the hypophysis of an Iranian rodent, (Ellobius lutescens (Th): gonadotropic and thyrotropic cells]. PMID- 4339508 TI - [Morphological aspects of infiltrating brain-stem tumors]. PMID- 4339509 TI - Equine abortion (herpes) virus: strain differences in susceptibility to inactivation by dithiothreitol. AB - The infectivity of equine abortion (herpes) virus (EAV) was inactivated by treatment with reduced dithiothreitol (DTT). According to their susceptibility to DTT, the EAV strains could be divided into three groups. The vaccine strain RAC-H (419) proved to be more resistant to DTT than all of the other 14 strains tested. The hemagglutinin of EAV was also inactivated by DTT; no strain differences were observed in this respect. PMID- 4339510 TI - [Morphological characteristics of the bone marrow in erythremia]. PMID- 4339512 TI - [Mathematical model of presynaptic inhibition]. PMID- 4339511 TI - [Etiology, epidemiology and pathology of leukemia]. PMID- 4339514 TI - [Study of the enzyme activity of myosin by the method of spin labels]. PMID- 4339513 TI - [Model of the process of peripheral inhibition in crustacean muscles]. PMID- 4339515 TI - [Free radical content in various parts of hybrid and inbred seeds]. PMID- 4339516 TI - The neuological hand. PMID- 4339518 TI - [Active metabolites of vitamin D]. PMID- 4339517 TI - [Stimulation of ADP polymerization by poly U with polynucleotide phosphorylase from Clostridium perfringens]. PMID- 4339519 TI - Collagen biosynthesis during connective tissue development in chick embryo. PMID- 4339520 TI - Correlation of cellulose synthesis in vivo and in vitro during the encystment of Acanthamoeba. PMID- 4339521 TI - Amino acid pools in developing oocytes of Xenopus laevis. PMID- 4339522 TI - [Convergence of rod and cone afferent systems on neurons of the primary visual cortex in the cat]. PMID- 4339523 TI - Smooth endoplasmic reticulum proliferation in mouse enterocytes induced by fructose feeding. PMID- 4339524 TI - Effect of corticotrophin on protein and phospholipid metabolism in subcellular fractions of adrenal glands. PMID- 4339525 TI - Inactivation of myosin ATPase by condensed polysilicic acid powders. PMID- 4339526 TI - Partial purification of NADH-cytochrome b 5 reductase from rabbit liver microsomes with detergents and its properties. PMID- 4339527 TI - Detection of arginine esterase of various kallikrein preparations on gellified electrophoretic media. PMID- 4339528 TI - Transepithelial potential changes during stimulation of isolated salivary glands with 5-hydroxytryptamine and cyclic AMP. PMID- 4339529 TI - Studies in prebiotic synthesis. VI. Synthesis of purine nucleosides. PMID- 4339530 TI - Studies on cerebral energy metabolism during the course of galactose neurotoxicity in chicks. PMID- 4339531 TI - Control of aerobic glycolysis in guinea-pig cerebral cortex slices. PMID- 4339532 TI - The partial purification and characterization of thiamine pyrophosphatase from rabbit brain. PMID- 4339533 TI - Long-term follow-up of children with steroid-responsive nephrotic syndrome. PMID- 4339534 TI - Hepatic dysfunction after renal transplantation in children. PMID- 4339536 TI - Nursery-acquired cytomegalovirus infection in two premature infants. PMID- 4339535 TI - Serum parathyroid hormone in hypophosphatemic vitamin D-resistant rickets. PMID- 4339537 TI - [Case of breast cancer with esophageal metastasis causing dysphagia]. PMID- 4339538 TI - [Case of polycystic liver associated with hepatoma and cirrhosis]. PMID- 4339539 TI - Thayer lectures. I. Principles of myopathology. II. Principles of clinical myology. PMID- 4339540 TI - [The experimental studies on antituberculous activity of lividomycin]. PMID- 4339542 TI - [Concentration of renin substrate (angiotensinogen) in maternal and fetal blood]. PMID- 4339543 TI - [Uremic neuropathy in relation duration of dialysis and dialyzer]. PMID- 4339544 TI - [Thymoleptic therapy of sleep disorders. Sleep registration following opipramol administration]. PMID- 4339541 TI - [Recent views on the biochemical aspects of the mode of action of analgesics acting like morphine in the central nervous system]. PMID- 4339545 TI - How to help your patients sleep better. PMID- 4339546 TI - Regeneration of protoplasts of Histoplasma capsulatum: a study by light microscopy. PMID- 4339547 TI - Taxonomic application of isozyme patterns produced with disc electrophoresis of some myxomycetes, order Physarales. PMID- 4339548 TI - Micro indirect hemagglutination test for detecting antibody against infectious bovine rhinotracheitis virus. PMID- 4339550 TI - Filtrability of equine infectious anemia virus. PMID- 4339549 TI - Histopathologic comparison of Marek's disease with avian lymphoid leukosis. PMID- 4339551 TI - [Metabolic processes in bone and muscle tissues during ontogenesis under the influence of 6-mercaptopurine]. PMID- 4339552 TI - [Multicentric reticulohistiocytosis and generalized eruptive histiocytoma]. PMID- 4339553 TI - [Perforating neurilemmoma of the jugular foramen]. PMID- 4339554 TI - [Results of dispenserization of convalescents recovering from infectious hepatitis]. PMID- 4339555 TI - [Indications for surgical treatment of cervical chemodectomas]. PMID- 4339556 TI - [Head trauma as a provoking factor in brain tumors with a latent course]. PMID- 4339557 TI - [The state of normal intestinal microflora in acute respiratory viral diseases in young children]. PMID- 4339558 TI - [Generalized cytomegaly with developmental anomaly of the kidneys and liver lesions]. PMID- 4339559 TI - [The possible blastomogenic effect of tubazid and phthivazid in experiments on animals]. PMID- 4339560 TI - [Interiliac-abdominal amputation in the treatment of malignant tumors of the pelvis and femur]. PMID- 4339561 TI - [Radioisotope scanning in the topical diagnosis of malignant neoplasms in children]. PMID- 4339562 TI - Development of the Mauthner cell in Xenopus laevis: a light and electron microscopic study of the Perikaryon. PMID- 4339563 TI - [Radiotherapy and surgery for maxillo ethmoidal cylindroma]. PMID- 4339564 TI - Electron microscopy of the paracervical (Frankenhauser) ganglion of the adult rat. PMID- 4339565 TI - Fine structure of the hamster Harderian gland. PMID- 4339566 TI - Ultrastructural changes in developing midgut epithelium of Calliphora erythrocephala Meigen. PMID- 4339567 TI - [Study of the pars intermedia of the hypophysis in normal and thyroidectomized mice: volumetry, histology and incorporation of various radioactive elements]. PMID- 4339569 TI - Ultrastructural study of cellular degeneration in the androgenic gland of the ghost crab, Ocypode quadrata (Fabr.). PMID- 4339568 TI - Cytophysiological features of hemocytes in cockroaches. PMID- 4339570 TI - [Myocardial contractility in coronary arteriosclerosis patients during repose, under auricular stimulation and under angiotensin perfusion]. PMID- 4339571 TI - [Relation between metabolism and contractility]. PMID- 4339572 TI - Effects of Herpesvirus hominis type 2 on human cervical epithelium: scanning electron microscopic observations. PMID- 4339573 TI - [Disodium cromoglycate in the treatment of asthma in childhood]. PMID- 4339574 TI - [Long term results of the treatment of hemochromatosis by repeated bloodletting. Apropos of the article of F. Darnis, A. Mosse and collaborators]. PMID- 4339575 TI - [Endocrine syndromes in hemochromatosis]. PMID- 4339576 TI - [Proteic hormones in the diabetes of hemochromatosis]. PMID- 4339577 TI - Catecholamines in the brain as mediators of amphetamine psychosis. PMID- 4339578 TI - The inhibition of L(--)-palmitylcarnitine oxidation by -ketoglutarate in rat liver mitochondria. PMID- 4339579 TI - One-electron transfer reactions in biochemical systems. VI. Changes in electron transfer mechanism of lipoamide dehydrogenase by modification of sulfhydryl groups. PMID- 4339580 TI - New sensitive method for the spectral analysis of respiratory-chain components in mitochondria. PMID- 4339581 TI - Cytochrome c reactivity in its complexes with mammalian cytochrome c oxidase and yeast peroxidase. PMID- 4339583 TI - Studies on spin-labeled polyriboadenylic acid. PMID- 4339582 TI - Characterization of primary reactants in bacterial photosynthesis. I. Comparison of the light-induced EPR signal (g=2.0026) with that of a bacteriochlorophyll radical. PMID- 4339584 TI - [Ultrastructure of lymph node plasmocytes appearing after irradiation]. PMID- 4339585 TI - Adrenal insufficiency in myasthenia gravis. A possible cause of adrenocorticotropic hormone (ACTH) treatment failure. PMID- 4339586 TI - [A common radioactive support for various titratable antigens, a future possibility for radioimmunology?]. PMID- 4339587 TI - Malate dehydrogenase in maize endosperm: the intracellular location and characterization of the two major particulate isozymes. PMID- 4339588 TI - Regulation by phosphoenolpyruvate of fructose-1,6-diphosphatase in skeletal muscle: evidence for an allosteric activator of the enzyme. PMID- 4339590 TI - Socialization program as part of aftercare planning. PMID- 4339589 TI - Idiopathic hypoparathyroidism with impaired vitamin B 12 absorption and neuropathy. AB - A 68-year-old man presenting with chronic intermittent diarrhea and progressive ataxia was found to have idiopathic hypoparathyroidism. Intrinsic factor resistant vitamin B(12) malabsorption was demonstrated. Both the diarrhea and vitamin malabsorption were reversed by correction of hypocalcemia.His neurological profile was a combination of peripheral nerve, posterior column and cerebellar deficits. He had calcifications in the dentate nuclei of the cerebellum. Possible etiological factors such as vitamin B(12) deficiency, folic acid deficiency and steatorrhea have been excluded. Posterior column and cerebellar abnormalities improved with treatment. It is postulated that hypocalcemia causes functional, reversible spinal cord and cerebellar dysfunction. PMID- 4339591 TI - Studies on dextrans and destranases. IX. Dextrans elaborated by cariogenic organisms. PMID- 4339592 TI - Wheat germ agglutinin titres of normal and transformed Chinese hamster cells and human and guinea pig erythrocytes: variations related to cell preparation. PMID- 4339593 TI - Studies on the role of the pituitary gland in biosynthesis of corticosteroid binding globulin in the male rat. PMID- 4339594 TI - Urinary lactic dehydrogenase activity. Posture dependent activity changes for the diagnosis of unilateral nephroptosis. PMID- 4339595 TI - [Role of thiamine in the nervous function]. PMID- 4339597 TI - Failure of corticosteroid implants in extrahypothalamic limbic structures to inhibit adrenocortical responses to stressful stimuli in the rat. PMID- 4339596 TI - [Effect of psychotropic drugs on the K + -dependent phosphatase activity in guinea pig brain microsomes]. PMID- 4339598 TI - Electron-donor-acceptor complexing reagents for the analysis of pesticides. I. Survey of reagents and instrumental techniques. PMID- 4339599 TI - Chromatography of crude aflatoxins on adsorbosil-5. PMID- 4339600 TI - Improvement of the AOAC kilogram sample method for the isolation of aflatoxin B 1 for chemical and biological conformation. PMID- 4339602 TI - Gas chromatographic determination of monitor (O,S-dimethyl phosphoramidothioate) residues in crops. PMID- 4339601 TI - Variations of florisil activity: method to increase retentive properties and improve recovery and elution patterns of insecticides. PMID- 4339603 TI - Simplified procedure for the purification of ochratoxin A from extracts of Penicillium viridicatum. PMID- 4339604 TI - Collagenase: a new assay. PMID- 4339605 TI - [The significance of fibrinolysis in cancer of the cervix uteri and trophoblastic neoplasias]. PMID- 4339606 TI - [Isolation of catabolite repressive anc cyclic AMP mutants]. PMID- 4339607 TI - Experimental infection of rabbits and monkeys with Herpesvirus cuniculi. PMID- 4339608 TI - Meningo-encephalitis in gnotobiotic pigs inoculated intransally and orally with porcine adenovirus 4. PMID- 4339609 TI - Meningo-encephalitis in two gnotobiotic calves infected intranasally and orally with infectious bovine rhinotracheitis virus. PMID- 4339610 TI - [A new class of welchicins]. PMID- 4339611 TI - Renal responses to saline load and to angiotensin in hypertensive rats. PMID- 4339612 TI - A tentative unifying view of bacteria. PMID- 4339613 TI - Effects of angiotensin on vesicles of sympathetic nerve endings in rabbit atria. PMID- 4339614 TI - Studies on the mechanism of hormone action. PMID- 4339615 TI - Adenosine 3',5'-monophosphate is localized in cerebellar neurons: immunofluorescence evidence. AB - Adenosine 3',5'-monophosphate is localized in specific cerebellar neurons, as shown by fluorescence immunocytochemistry with a specific rabbit immunoglobulin. Positive staining is exhibited by Purkinje neurons and granule cells. The increase in concentration of cyclic adenosine monophosphate in the cerebellum, which is known to follow decapitation, is represented by greatly increased fluorescence of Purkinje neurons only. These immunofluorescence data provide the first evidence for localization of cyclic adenosine monophosphate in specific neurons and may permit further exploration into the role of this cyclic nucleotide in neuronal function. PMID- 4339616 TI - Photoreception in a barnacle: electrophysiology of the shadow reflex pathway in Balanus cariosus. AB - The photoreceptors in the median ocellus of the rock barnacle depolarize when illuminated. This depolarization spreads passively to the axon terminals in the supraesophageal ganglion. A small number of cells in the supraesophageal ganglion hyperpolarize when the median ocellus is illuminated and depolarize when it is shadowed. Nerve impulses are superimposed on the slow depolarization of the ganglion cells. Impulse activity in response to shadowing the median ocellus is recorded in a few fibers of the circumesophageal connectives. Picrotoxin blocks this shadow-induced activity. A model of the shadow reflex pathway is presented. PMID- 4339618 TI - Treatment of corneal destruction with collagenase inhibitors. PMID- 4339617 TI - [Changes in blood leukocyte alkaline phosphatase, peroxidase, and cytochrome oxidase in pneumoconiosis patients]. PMID- 4339619 TI - Epidemic keratoconjunctivitis: a new approach. PMID- 4339621 TI - [Proteolytic enzymes of the larvae of Hypoderma bovis (De Geer) (Diptera, Hypodermatidae)]. PMID- 4339620 TI - Fine structural aspects of early development of Eimeria ninakohlyakimovae in cultured cells. PMID- 4339622 TI - [Freeze-preservation of pathogenic amoebae and trichomonads]. PMID- 4339624 TI - Breast cancers that kill. A pilot study. Cytological typing in infiltrating scirrhous, duct and adenocarcinomas of the breast. PMID- 4339623 TI - [Tar-induced acanthosis of the guinea pig nipple. II. Enzyme histochemical observations]. PMID- 4339625 TI - Stimulation of lipolysis and cyclic AMP accumulation in rabbit fat cells by human growth hormone. PMID- 4339626 TI - Effect of growth in vivo and in vitro on phenotype of hexokinase isozymes in hepatoma cells. PMID- 4339627 TI - Autonomous cholesterol and fatty acid synthesis in hepatomas: deletion of the adenosine 3',5'-cyclic monophosphate control mechanism of normal liver. PMID- 4339628 TI - Regulation of parathyroid hormone secretion by adrenyl cyclase. PMID- 4339629 TI - A review of the recent literature on diseases of the vulva. II. Vulvitis: infections. PMID- 4339630 TI - Changes during weeks in effects of tricyclic drugs on the human sleeping brain. PMID- 4339631 TI - On the slowness of action of tricyclic antidepressant drugs. PMID- 4339632 TI - [Viral complications of renal transplantation]. PMID- 4339633 TI - [Therapeutic use of antibiotic combinations]. PMID- 4339634 TI - Preliminary clinical trials of dichloromethotrexate (NSC-29630) in hepatocellular carcinoma. PMID- 4339635 TI - [Problem of salivary gland tumors]. PMID- 4339636 TI - [The use of autologous transplants in traumatic lesions of peripheral nerves]. PMID- 4339637 TI - Development of a miniature fast analyzer. PMID- 4339638 TI - Nonlinear regression analysis approach for determining "true" lactate dehydrogenase activity in serum with the centrifugal analyzer ("Rotochem"). PMID- 4339639 TI - [Inhibiting action of 1-adamantaneamine and alpha-methyl-1-adamantane-methylamine on the development of Rous sarcoma]. PMID- 4339640 TI - [Induction of protein synthesis by animal cell mitochondria due to cyclic 3',5' AMP]. PMID- 4339641 TI - Structural features of ring A and the interaction of 20-oxosteroids with cortisone reductase. PMID- 4339642 TI - RNA polymerase from eukaryotic cells. Isolation and purification of enzymes and factors from chromatin of coconut nuclei. PMID- 4339643 TI - Transcriptional control of tryptophanase synthesis by cyclic AMP in Escherichia coli. PMID- 4339644 TI - Light-absorption studies on neutral flavin radicals. PMID- 4339645 TI - Preparation and characterization of fragments from yeast tRNA phe . PMID- 4339646 TI - Purification and characterization of pyruvate-dehydrogenase phosphatase from pig heart muscle. PMID- 4339647 TI - Recent advances in molecular pathology. The state of the viral genome in cells transformed by simian virus 40: a review. PMID- 4339649 TI - Production of lymphomata following intrapleural inoculation of silica. PMID- 4339648 TI - Metabolic activities of thyroid gland from theophylline-treated rats. PMID- 4339651 TI - Disease hazard of pathogenic organisms in farm waste material. PMID- 4339652 TI - Treatment of moderately severe erythema nodosum leprosum with clofazimine--a controlled trial. PMID- 4339650 TI - Consumption of oxygen by the muscles of beef animals and related species. II. Consumption of oxygen by post-rigor muscle. PMID- 4339653 TI - [Effect of extracellular polarization on the neuronal activity of external geniculate bodies]. PMID- 4339654 TI - [Non-adrenergic inhibitory postsynaptic potentials of stomach smooth muscle cells]. PMID- 4339655 TI - Spinal arteriovenous malformation diagnosed by gas myelography. PMID- 4339656 TI - Tumours of the basal ganglia: an angiographic study. PMID- 4339658 TI - [The birth of French neurosurgery]. PMID- 4339657 TI - [Vitamin D. Current knowledge. Personal studies apropos of 25-OH-D3]. PMID- 4339660 TI - Temporal organization of night workers' sleep. PMID- 4339659 TI - Protective action of the aspartic acid on liver steroid dehydrogenases in experimental chronic intoxication with carbon tetrachloride. PMID- 4339661 TI - [Study of norepinephrine fixation on adrenergic nerve fibers]. PMID- 4339662 TI - Orbital tumours in Iraq. PMID- 4339663 TI - Survival in bronchial carcinoma. Tumour remaining in the bronchial stump following resection. PMID- 4339664 TI - Experimental induction of a new type of murine leukosis following ingestion of human neoplasms. PMID- 4339665 TI - Topical fluorouracil treatment of senile keratosis and mycosis fungoides. A clinical and ultrastructural study, with special reference to nucleolar structure. PMID- 4339666 TI - [Transplacental induction of nervous system tumors. Comparison of effectivity of methyl- and ethylnitrosourea]. PMID- 4339667 TI - [Renin and renin substrate in pregnancy]. PMID- 4339668 TI - [Androblastoma of the ovaries induced by penetrating radiation]. PMID- 4339670 TI - Model neural systems and strategies for the neurobiology of learning. PMID- 4339671 TI - Aging and sleep in the albino rat. PMID- 4339672 TI - Further studies on the translation of globin mRNA and encephalomyocarditis virus RNA in a cell-free system from Krebs II ascites cells. PMID- 4339673 TI - In vitro RNA synthesis from unique pieces of simian virus 40 DNA produced by a restriction endonuclease. PMID- 4339674 TI - Isolation of a lysine transfer ribonucleic acid species from Bacillus subtilis by use of chemical modification. PMID- 4339675 TI - On the arousal state-dependent recall of 'subconscious' experience: stateboundness. PMID- 4339676 TI - A qualitative spot test for cystinuria. PMID- 4339678 TI - [Importation of poliovirus into the Federal Republic of Germany from endemic areas]. PMID- 4339677 TI - The quantitative determination of fecal bile acids in children by the enzymatic method. PMID- 4339681 TI - [Mass screening of the hip joints in infants, and radiation protection (an expertise of the German Roentgen Society)]. PMID- 4339679 TI - [Function studies of the hypothalamus-anterior-pituitary-adrenal cortex system following surgery of cortisol-producing adrenal gland adenoma]. PMID- 4339680 TI - [Isoprinosine: evaluation of its virus inhibiting action in vivo and in vitro]. PMID- 4339682 TI - [Fibrous dysplasia of the bone in the region of the paranasal sinuses]. PMID- 4339683 TI - [The relationship between the width, depth and area of thoracic and lumbar vertebral bodies]. PMID- 4339684 TI - [Clefts of the vertebral arch (observation of a retrosomatic cleft)]. PMID- 4339685 TI - [Late spondyloepiphyseal dysplasia. 2 case reports]. PMID- 4339686 TI - [The radiological differentiation between psoriatic spondyloarthritis and spondyloarthritis ankylopoetica in patients with psoriasis]. PMID- 4339687 TI - [Shoulder arthrography in primary chronic polyarthritis]. PMID- 4339688 TI - [Findings following gracilis tendon plastic surgery for varicosis of the lower extremities, with special reference to results of phlebographic studies]. PMID- 4339689 TI - [The differential diagnosis of neoplastic processes in the duodenum]. PMID- 4339690 TI - [Value of evidence from hypotensive duodenography for the diagnosis and differential diagnosis of duodenal and pancreatic diseases]. PMID- 4339691 TI - [The technique of duodenoscopy with retrograde pancreato- and cholangiography]. PMID- 4339692 TI - [Extensive lymphatic hyperplasia in the gastro-intestinal tract in lymphosarcomatosis]. PMID- 4339694 TI - [Reduction in radiation dose. Pulmonary scanning with 99m-Tc-micro-spheres]. PMID- 4339693 TI - [Intensified roentgen diagnosis of the stomach using double contrast. Report on a new additive agent for contrast media examination]. PMID- 4339696 TI - [Changes in the density and thickness of the phalanges due to age and disease. Radiological measurements with 125 I profile scanner in 223 women]. PMID- 4339695 TI - [Computer scintigraphy of pulmonary circulation. 3. Perfusion pattern in obstructive syndrome and relations to lung function and hemodynamics of the pulmonary circulation]. PMID- 4339698 TI - [Myositis ossificans of the hip joint]. PMID- 4339697 TI - [Distension dislocation of the hip joint with proximal femoral epiphyseolysis due to birth injury]. PMID- 4339699 TI - [Osteoid osteoma in the parietal bone]. PMID- 4339700 TI - [Hemangioma of the rib]. PMID- 4339701 TI - [Destructive bone processes in early infancy]. PMID- 4339702 TI - [Interphalangeal dislocation of the big toe with interposition of a sesamoid bone]. PMID- 4339703 TI - [Neurofibroma of the small intestine]. PMID- 4339704 TI - [Giant lipoma of the colon]. PMID- 4339705 TI - [Detection of the virus after remission of human herpetic keratitis]. PMID- 4339706 TI - [Experimental study of the antiviral activity of distamycin A. (Preliminary note)]. PMID- 4339707 TI - Photoinduced phenoxy radical of 3,4-benzopyrene. PMID- 4339709 TI - Influence of blood transfusion on induction of hepatoma inrats fed 4 (dimethylamino) azobenzene. PMID- 4339708 TI - Peritoneal bleeding of the rat bearing ascites hepatoma, Ah-13. PMID- 4339710 TI - Spontaneous endocrine tumors in mastomys. PMID- 4339711 TI - Changes in the activities of glucose-6-phosphatase, aldolase, and alkaline phosphatase during azo-dye carcinogenesis. PMID- 4339713 TI - Impaired synthesis of liver catalase in tumor-bearing rats. PMID- 4339712 TI - Antibodies to a new antigen induced by Epstein-Barr virus in patients with nasopharyngeal carcinoma, leukemia, malignant lymphoma, and in control groups. PMID- 4339714 TI - Production of infective Epstein-Barr virus in a Burkitt lymphoma cell line, P3HR 1. PMID- 4339716 TI - [Local treatment of skin neoplasms with 5 per cent fluorouracil ointment (report of 6 cases)]. PMID- 4339715 TI - The reactivity of aged mice to Bordetella pertussis as an immunological adjuvant. PMID- 4339717 TI - [Skin lesions due to an anachronistic treatment]. PMID- 4339718 TI - Studies on succinate dehydrogenase. XX. Amino acid sequence around the flavin site. PMID- 4339720 TI - The examination of the presence of amide groups in glutamic acid and aspartic acid residues of staphylococcal nuclease (Foggi strain). PMID- 4339719 TI - Treatment of bovine nasal cartilage proteoglycan with chondroitinases from Flavobacterium heparinum and Proteus vulgaris. PMID- 4339721 TI - Binding of iron and copper to bovine heart mitochondria. II. Effect of mitochondrial metabolism. PMID- 4339722 TI - Adenoid cystic carcinoma of the mandible. PMID- 4339723 TI - [Secretion of insulin, with special reference to the secretory mechanism]. PMID- 4339724 TI - [Case of fibroadenoma phyllodes of the breast]. PMID- 4339725 TI - Exogenous fatty acids and triglyceride production in rat liver. PMID- 4339726 TI - Polyribosomes of normal and SV40(MK 2 ) virus-infected LLC-MK 2 cells. PMID- 4339727 TI - [Modern views on the role of adenyl cyclase and cyclic 3', 5', AMP in the heart]. PMID- 4339728 TI - [Glucocorticoid function of the adrenal cortex in tranplantable cerebellar glioblastoma multiforme against a background of experimental hyperthyroidism]. PMID- 4339730 TI - [Fusion of normal cells with different organ and tissue specificity, with each other or with tumor cells]. PMID- 4339729 TI - [Significance of hypoxia in the pathogenesis of neoplasms]. PMID- 4339731 TI - A comparative ultrastructural study on ultimobranchial glands of some Israeli anurans (Bufo viridis, Rana ridibunda and Hyla arborea). PMID- 4339733 TI - Germfree environment and adrenocortical function in the rat. PMID- 4339732 TI - Giganto-cellular glioblastoma of the lumbosacral spinal cord. PMID- 4339734 TI - Purification and characterization of the flavin prosthetic group of sarcosine dehydrogenase. PMID- 4339735 TI - Developmental changes in cyclic AMP, protein kinase, phosphorylase kinase, and phosphorylase in liver, heart, and skeletal muscle of the rat. PMID- 4339736 TI - Purification of a DFP-hydrolyzing enzyme from squid head ganglion. PMID- 4339737 TI - Evidence for a single macromolecular form of lactate dehydrogenase in Artemia salina. PMID- 4339738 TI - Electron paramagnetic resonance and temperature dependent spin state studies of ferric cytochrome P-450 from Rhizobium japonicum. PMID- 4339739 TI - Glucose formation by the 27,500g supernatant fraction of rat liver homogenate. PMID- 4339740 TI - The effect of divalent metal binding on the electron spin resonance spectra of spin-labeled actin. Evidence for spin-spin interactions involving manganese. II. PMID- 4339741 TI - Biochemistry of depression (a review of the literature). PMID- 4339742 TI - Effects of glucagon and cyclic AMP on ion fluxes in the perfused liver. PMID- 4339743 TI - Isolation and composition of human thymocyte plasma membrane. PMID- 4339745 TI - Erythrocyte membranes--compression of lipid phases by increased cholesterol content. PMID- 4339744 TI - Studies of the plasma membrane of normal and virus-transformed 3 T 3 mouse cells. PMID- 4339746 TI - Neurological disease in man following administration of suckling mouse brain antirabies vaccine. AB - In Latin America, suckling mouse brain (SMB) vaccine has become the most commonly used vaccine for immunization of both man and animals against rabies. This vaccine is highly immunogenic, is relatively economical and easy to produce, and is believed to be free of the immunoencephalitogenic factor. From 1964 to the end of 1969, there were 40 reported cases of neurological disease following administration of SMB vaccine, 32 of which met the criteria for inclusion in this report. These 32 cases occurred in 8 different countries. In contrast to neurological disease following the administration of other types of nervous tissue vaccine, the majority of the cases following vaccination with SMB vaccine had a Guillain-Barre-type syndrome with peripheral nervous system involvement and a higher case-fatality rate. The causative agent has not been demonstrated. Modifications in the production and handling of the vaccine may be producing changes that are responsible. PMID- 4339747 TI - The development of specific cellular and humoral immunity in mice infected with Rauscher leukemia virus as neonates or adults. PMID- 4339748 TI - Subcellular localization of surface adenosine triphosphatase activity in preneoplastic liver parenchyma. PMID- 4339750 TI - Studies on adrenocortical carcinoma of rat cyclic nucleotide phosphodiesterase activities. PMID- 4339749 TI - Immunoepidemiological and in vitro studies of possible relationships between Australia antigen and hepatocellular carcinoma. PMID- 4339751 TI - Association of exogenous RNA with Novikoff hepatoma ascites cells. PMID- 4339752 TI - A surface 3'-exonuclease of Novikoff hepatoma ascites cells. PMID- 4339753 TI - Aspartyl transfer RNA profiles in normal and cancer cells. PMID- 4339754 TI - Parenteral sodium epicillin in acute infections. PMID- 4339755 TI - [Metabolism of phospholipid fractions in rat brain during narcotic (thiopental) sleep]. PMID- 4339756 TI - [Experience in the sanitary-virological examination of waste waters]. PMID- 4339757 TI - Insulin levels in Nigerian adults, children and pregnant women. PMID- 4339758 TI - Glucose metabolism of pancreatic islets isolated from neonatal rats. PMID- 4339759 TI - Inhibition of lipid synthesis by epinephrine in isolated rat liver cells. PMID- 4339761 TI - Adenocortical responsiveness to physiological amounts of 1-24 ACTH. I. Effect of prior administration of dexamethasone. PMID- 4339762 TI - Hormonal dependence of cholesterol ester hydrolase in the corpus luteum and adrenal. PMID- 4339760 TI - Effects of adrenalectomy and resubstitution with moderate and high doses of cortisone acetate on lipolysis and 47 calcium uptake in rat adipose tissue in vivo. PMID- 4339763 TI - Pseudoangiotensin II in gastric juice. PMID- 4339764 TI - Cyclic 3',5'-AMP and gastric secretion in the rat: effect of adrenalectomy and glucocorticoids. PMID- 4339766 TI - Oculomotor coordination following REM and non-REM sleep periods. PMID- 4339765 TI - Cessation of drinking following intracranial injections of angiotensin in the rat. PMID- 4339767 TI - Isolation of parietal cells from glutaraldehyde-fixed rabbit stomach. PMID- 4339768 TI - Salivary gland tumours. PMID- 4339769 TI - Synthesis of some analogs of angiotensin II as specific antagonists of the parent hormone. PMID- 4339770 TI - cis- and trans-2-Mercaptocyclobutylamines. Synthesis and antilipolytic properties in vitro. PMID- 4339771 TI - Azapurine nucleosides. 3. Synthesis of 7-( -D-ribofuranosyl)imidazo(4,5-d)-v triazin-4-one(2-azainosine) and related derivatives. PMID- 4339772 TI - Anticonvulsant activity of nitrobenzamides and their inhibition of nicotinamide adenine dinucleotide dependent oxidations. PMID- 4339774 TI - Vaccination against pertussis. PMID- 4339773 TI - Synthesis of some spin-labeled analogs of drug molecules. PMID- 4339776 TI - Assessment of bone maturation--methods and pitfalls. PMID- 4339775 TI - Cirrhosis of the liver: principles of classification, histogenesis, and pathogenesis. PMID- 4339777 TI - The uses and abuses of abdominal and peripheral arteriography in children. PMID- 4339778 TI - Cyclic AMP. PMID- 4339779 TI - Behavioral symptoms with intracranial neoplasm. PMID- 4339780 TI - [Psychotherapy and progress. Psychological importance of cults and customs]. PMID- 4339781 TI - [Morphological studies of the liver and small intestine, as well as of serum lipid chemistry after ligation of the rat thoracic duct]. PMID- 4339783 TI - Isolation, cultivation and characterization of camel pox virus. PMID- 4339782 TI - [Mutual relations between adrenal gland hormones and lipid metabolism]. PMID- 4339784 TI - [Serological studies on the occurrence and spread of reovirus infections in Bavarian pig herds]. PMID- 4339785 TI - [Characterisation of a pox virus from quail]. PMID- 4339786 TI - Effects of the pineal gland in unilaterally adrenalectomized rats. PMID- 4339787 TI - [Investigation on tetrahydroaldosterone excretion in childhood using gas chromatography with an electron capture detector]. PMID- 4339789 TI - Allergic rhinitis and constitutional growth delay. PMID- 4339788 TI - Steroid excretion and biosynthesis, with special reference to 16-unsaturated C 19 steroids, in cases of testicular feminization and in a male pseudohermaphrodite. PMID- 4339790 TI - The properties of the mitochondrial succinate-cytochrome c reductase. PMID- 4339791 TI - The chemical properties of cytochrome c oxidase in intact mitochondria. PMID- 4339792 TI - The energy dependence of the chemical properties of cytochrome c oxidase. PMID- 4339793 TI - Interaction of viral RNA with Escherichia coli. 1. Polycation augmented adsorption of poliovirus-induced double-stranded RNA. PMID- 4339795 TI - 3-Hydroxy-N-acetylneuraminic acid: synthesis and inhibitory properties. PMID- 4339794 TI - N-acetylneuraminic acid aldolase of Clostridium perfringens: purification, properties and mechanism of action. PMID- 4339796 TI - Studies on the electron transport chain at subzero temperatures: electron transport at site 3. PMID- 4339797 TI - -Keto acid dehydrogenase complexes. XVII. Kinetic and regulatory properties of pyruvate dehydrogenase kinase and pyruvate dehydrogenase phosphatase from bovine kidney and heart. PMID- 4339798 TI - Correlation of chaotropic effects of haloacetates with the hydrophobic parameter . PMID- 4339799 TI - Effectors of purified adenyl cyclase from Streptococcus salivarius. PMID- 4339801 TI - Model pores of molecular dimension. The preparation and characterization of track etched membranes. AB - Extremely uniform pores of near molecular dimension can be formed by the irradiation-etching technique first demonstrated by Price and Walker. The technique has now been developed to the stage where it can be used to fabricate model membranes for examining the various steric, hydrodynamic, and electrodynamic phenomena encountered in transport through molecular-size pores. Methods for preparing and characterizing membranes with pores as small as 25 A (radius) are described in this paper. Results on pore size determination via Knudsen gas flow and electrolyte conduction are compared. Pore wall modification by monolayer deposition is also discussed. PMID- 4339800 TI - The redox-state in relation to ethanol metabolism by rat and guinea pig liver in vitro. PMID- 4339802 TI - Australia antigen and antibodies to Epstein Barr virus cytomegalovirus and rubella virus in dental personnel. PMID- 4339803 TI - Comparison of effects on macrophage cultures of glass fibre, glass powder, and chrysotile asbestos. PMID- 4339804 TI - Absorption of serum proteins by inorganic dusts. PMID- 4339806 TI - [Study of the specificity of the FSH assay method based on the counting of luteinic formations in the ovary of the immature rat]. PMID- 4339805 TI - [Diagnosis and therapy of circumscribed liver diseases]. PMID- 4339807 TI - [Fetal and neonatal sleep stages in cattle (Bos taurus)]. PMID- 4339808 TI - Blood and lymph vessel tumors. PMID- 4339809 TI - Unproven methods of cancer management. Issels combination therapy. PMID- 4339810 TI - [Changes in the protein content of neurons during inhibition of their activity]. PMID- 4339811 TI - [Medial eminence of the neurohypophysis in extreme conditions]. PMID- 4339812 TI - [Why intratypical differentiation of poliovirus strains?]. PMID- 4339813 TI - [Basic problems in industrial hygiene in the production of quartz glass]. PMID- 4339814 TI - Action of epinephrine and other cyclic AMP-mediated agents on the chloride transport of the frog cornea. PMID- 4339816 TI - Increasing consumer partcipation in professional goal setting: contraception and therapeutic abortion. PMID- 4339817 TI - Gas-liquid chromatographic determination of vitamins D 2 and D 3 in infant formulas and feeding preparations. PMID- 4339818 TI - Collagen substrata for studies on cell behavior. AB - A simple technique is described for the preparation of collagen substrata containing 0 1% of collagen by weight, in the form of native bundles with a 640 A period, the substrata are similar in these respects to soft-tissue matrices These substrate are hydrated collagen lattices (HCLs) in which the watery milieu is held within a fibrous collagen net mainly by capillary forces. HCLs have been characterized in terms of the course of collagen precipitation and aggregation, ultrastructure, and their stability under various conditions. The ways in which HCLs can be employed as both two- and three-dimensional substrata in cell behavioral studies are illustrated with some preliminary observations on the form, motility, adhesion, and growth of human diploid cells and two lines of malignant cells. PMID- 4339819 TI - The isolation of mouse hepatocyte gap junctions. Preliminary chemical characterization and x-ray diffraction. AB - A method is reported for isolating a preparation of hepatic gap junctions from the mouse. The method involves a collagenase digestion, treatment with the detergent Sarkosyl NL-97, and ultrasonication, followed by sucrose gradient ultracentrifugation. A run with 36 animals yields 0.1-0.5 mg protein. Electron microscopy with thin-sectioning and negative staining techniques reveals that the final pellet is a very pure preparation of gap junctions, accompanied by a small amount of amorphous contamination. Polyacrylamide-gel electrophoresis of sodium dodecyl sulfate (SDS)-solubilized material shows one major protein in the junction, with an apparent mol wt of 20,000, and two minor components. Thin-layer chromatography demonstrates one major and one minor phospholipid, and some neutral lipid. Low-angle X-ray diffraction of wet and dried specimens show reflections which index on an 86 A center-to-center hexagonal lattice, corresponding closely to electron microscope data. Dried specimens also show a lamellar diffraction, corresponding to the total profile thickness of the junction (150 A). PMID- 4339820 TI - Polymorphonuclear leukocyte motility in vitro. VI. Effect of purine and pyrimidine analogues: possible role of cyclic AMP. PMID- 4339821 TI - Evaluation of sickle hemoglobin and desickling agents by falling ball viscometry. PMID- 4339822 TI - Pigmented epulis of infancy. PMID- 4339823 TI - Mathematical approach to the study of the cerebral cortex. IV. The spread of excitation in the space and time domains. PMID- 4339824 TI - Infection of colostrum-deprived baby pigs with a porcine enterovirus (Kr 69TC strain) isolated from the lung. PMID- 4339825 TI - [Role of arterial ground substance in the pathogenesis of atherosclerosis]. PMID- 4339827 TI - Radioactive colloids in the treatment of stage I A ovarian cancer. PMID- 4339826 TI - [Interrelations of atherosclerosis and rheumatism (lipid metabolism data)]. PMID- 4339828 TI - Measurement of total cerebrospinal fluid formation proximal to an acute cisternal block. PMID- 4339829 TI - Angiographic diagnosis of insulinoma in a 6-year-old boy. PMID- 4339830 TI - Paradoxical splenic enlargement following radiation therapy. PMID- 4339831 TI - [Trance-mediumism as group therapy. An aspect of the Brazilian Umbanda]. PMID- 4339832 TI - A comparative study of several diagnostic tests of colour vision used for measuring types and degrees of congenital red-green defects. PMID- 4339833 TI - [Influence of tweens 60 and 80 on the incorporation of radioactive inorganic phosphate and on the level of adrenal ascorbic acid]. PMID- 4339834 TI - Renal embryoma in an adult. PMID- 4339835 TI - Polyneuropathy in a glue sniffer. PMID- 4339836 TI - Entrapment neuropathy of anterior branch of axillary nerve: report of case. PMID- 4339837 TI - [Mechanism of formation of enzyme-substrate complexes in a microsomal hydroxylating system]. PMID- 4339838 TI - [Tumor lipids. Phospholipid exchange between mitochondria and microsomes of Zajdela ascitic hepatoma]. PMID- 4339840 TI - Meralgia paresthetica. PMID- 4339839 TI - Neural leprosy. PMID- 4339841 TI - Some remarks on the central nervous system. PMID- 4339842 TI - Assay of cyclo-3',5'-adenosine monophosphate (cAMP) in sub-picomole quantities using a covalent protein-sepharose complex. PMID- 4339843 TI - Effects of known and suspected neurotransmitter substances and of some nucleotides on isolated mast cells. PMID- 4339845 TI - A note on the polytene nuclei in the fat body of Drosophila larvae. PMID- 4339844 TI - The effect of vitamin D 3 and 25-hydroxycholecalciferol on intestinal transport of calcium in vivo and in vitro. PMID- 4339846 TI - [Determination of human motor and sensory neural conduction speed (electroneurography)]. PMID- 4339847 TI - Analysis of immunoglobulins in chicken antibody to avian leucosis viruses. PMID- 4339849 TI - Psychophysical evidence for lateral inhibition in hearing. PMID- 4339848 TI - Evaluating aftercare for former day treatment centre patients. PMID- 4339850 TI - [Histochemical studies on salivary gland tumors of Koreans]. PMID- 4339851 TI - Semi-in vitro repair of radiation-induced damage in transforming DNA of Bacillus subtilis. PMID- 4339852 TI - 5'-Oligonucleotides as the acid-soluble products of the ATP-dependent DNase form Escherichia coli. PMID- 4339853 TI - [Possibilities of errors in the pathologic-anatomical diagnosis of breast neoplasms]. PMID- 4339856 TI - Radical right hepatic lobectomy for hepatoblastoma in infancy. Firve-year survival. PMID- 4339854 TI - [Errors in indications for surgery of the breast]. PMID- 4339857 TI - Sleep and its disorders in infants and children: a review. PMID- 4339858 TI - Anatomy and surgical treatment of syndactylism. PMID- 4339859 TI - Alcoholism among prisoners. PMID- 4339860 TI - [Tumors of the palate of salivary origin. Diagnosis and treatment]. PMID- 4339861 TI - [Idiopathic sino-atrial blocks]. PMID- 4339862 TI - [Secondary sino-atrial blocks]. PMID- 4339863 TI - [Value of radioisotopic scanning of the myocardium and cardiac cavities in the supervision of myocardial infarcts]. PMID- 4339864 TI - [Clinical and histological study (ultrastructure) of pigmentation due to aminodarone hydrochloride. (Interpretations and analogies)]. PMID- 4339865 TI - [Bacterial endocarditis of the pulmonary orifice without a tricuspid lesion]. PMID- 4339866 TI - [Uhl's syndrome. Papyraceous right ventricle. Apropos of a clinical case with hemodynamic, angiographic and isotopic control]. PMID- 4339867 TI - [Outline of gastric physiology]. PMID- 4339868 TI - Taenia hydatigena. IV. Ultrastructure study of the tegument. PMID- 4339870 TI - Measurement of biological activity in various growth hormone preparations using a modified tibia test. PMID- 4339869 TI - Electron microscope observations of the body wall of Trichuris suis, Schrank, 1788 (Nematoda: Trichuroidea). II. The hypodermis and somatic musculature. PMID- 4339872 TI - The origin of double-minutes in a Rous rat sarcoma. PMID- 4339871 TI - Renal microthrombosis. Incidence in 500 consecutive autopsies. Clinico pathological relations. PMID- 4339873 TI - Oxygen-modified collagen and its possible pathological significance. PMID- 4339874 TI - Optics and visual physiology. PMID- 4339875 TI - Chemical synthesis of pyrophosphodiesters of carbohydrates and isoprenoid alcohols. Lipid intermediates of bacterial cell wall and antigenic polysaccharide biosynthesis. PMID- 4339876 TI - Formation of adenosine triphosphate in the oxidation of a model for the reduced pyridine nucleotides. PMID- 4339877 TI - Definition of three classes of binding sites in isolated microtubule crystals. PMID- 4339878 TI - Proteins exposed on the surface of mammalian membranes. PMID- 4339879 TI - Ligase joining of oligodeoxythymidylates. PMID- 4339880 TI - Synthesis and biological activity of several 6-substituted 9- -D ribofuranosylpurine 3',5',-cyclic phosphates. PMID- 4339881 TI - 5,6-Trans isomers of cholecalciferol and 25-hydroxycholecalciferol. Substitutes for 1,25-dihydroxycholecalciferol in anephric animals. PMID- 4339883 TI - Lack of relationship between myocardial cyclic AMP concentrations and inotropic effects of sympathomimetic amines. AB - 1. Sympathomimetic amines which increase the contractility of the isolated heart were tested for effects on cyclic AMP concentrations in rabbit heart slices and on adenyl cyclase activity in rabbit heart homogenate.2. Noradrenaline, as expected, stimulated adenyl cyclase activity and increased cyclic AMP concentrations, but dopamine and phenylephrine were ineffective.3. This result does not support the concept that cyclic AMP plays an essential role in the inotropic effect of sympathomimetic amines. PMID- 4339884 TI - Modification by choline of adrenergic transmission in rat mesenteric arteries. AB - 1. The action of choline on the vasoconstrictor responses of the perfused mesenteric arteries of the rat to sympathetic nerve stimulation and to injected noradrenaline has been investigated.2. The infusion of choline (500 mug/ml), for periods of 15 s, increased the response to sympathetic nerve stimulation, whereas the infusion of the same concentration for 20 min greatly reduced the response to nerve stimulation. Choline (up to 500 mug/ml), infused either for short or long periods, did not alter the response to injected noradrenaline.3. The inhibitory action of choline on the response to nerve stimulation was abolished either by an increase in the calcium concentration from 1.8 to 5.4 mM or by simultaneous infusion of (+)-amphetamine or atropine.4. The results suggest that choline in concentrations of 500 mug/ml has the same effect on adrenergic transmission in mesenteric arteries as acetylcholine at concentrations of 5 ng/ml. PMID- 4339882 TI - A new dopamine- -hydroxylase inhibitor: effects on the noradrenaline concentration and on the action of L-DOPA in the spinal cord. AB - 1. The dopamine-beta-hydroxylase inhibitor bis(4-methyl-1-homopiperazinyl thiocarbonyl) disulphide (FLA-63; 25 mg/kg i.p.) caused within 4 h a 65% loss of noradrenaline throughout the intact rat spinal cord and also cranial to a transection of the cut spinal cord. Caudal to the lesion, there was only an insignificant depletion of 17% indicating the importance of nerve impulses for the disappearance of noradrenaline.2. Dopamine accumulated in the spinal cord after treatment with FLA-63 although the amounts were not sufficient to replace the missing noradrenaline. Even after treatment with L-3,4-dihydroxyphenylalanine (L-DOPA), the catecholamine store was incompletely replenished by dopamine.3. After a large depletion of the noradrenaline stores, induced by repeated doses of FLA-63 or by reserpine plus FLA-63, the L-DOPA-induced increase in flexor reflex activity of the hind limbs of spinal rats was inhibited much more than after pretreatment with alpha-methyl-tyrosine or reserpine. FLA-63 blocked the formation of noradrenaline but not of dopamine from L-DOPA.4. The increase in flexor reflex activity induced by the noradrenaline receptor stimulating agent clonidine was not changed by FLA-63, indicating that the noradrenaline receptor sensitivity was not influenced.5. After depletion of the noradrenaline stores, the small formation of noradrenaline from L-DOPA may be of greater functional significance for the noradrenaline receptor stimulation than the greater formation of dopamine, but the dopamine formed also has a slight action. With intact noradrenaline stores, displacement of endogenous noradrenaline by newly formed dopamine contributes, at least after monoamine oxidase inhibition, to the increase in the flexor reflex activity caused by L-DOPA. PMID- 4339885 TI - Interaction between prostaglandins and gonadotrophins in the rabbit ovary. AB - 1. It has been suggested that prostaglandins function as feedback modulators of hormonal actions which are mediated by adenosine 3',5'-monophosphate (cyclic AMP). This hypothesis has been tested on the rabbit ovary, whose steroidogenic response to luteinizing hormone (LH) is mediated by the cyclic nucleotide.2. Prostaglandin E(1) (1-100 mug/ml) reduced the production of progesterone by rabbit ovaries incubated in the presence of a submaximal concentration of LH, but had no effect on the formation of this steroid when exogenous cyclic AMP was used as the stimulating agent. The prostaglandin was without effect on the formation of 20alpha-hydroxypregn-4-en-3-one in the presence of either LH or cyclic AMP.3. Prostaglandin E(2) (1 mug/ml) was without effect on ovarian steroidogenesis in the presence of LH.4. There was no evidence that exogenous prostaglandin E(1) was inactivated during incubation with rabbit ovaries in the presence of LH.5. Prostaglandin E-like compounds were detected in homogenates of incubated rabbit ovaries. However, concentrations of LH sufficient to stimulate steroidogenesis did not stimulate the synthesis of these compounds by the ovary in vitro, nor their release from the ovary in vivo.6. It is concluded that the prostaglandin like compounds detected in the ovary are unlikely to play a role in the regulation of steroidogenesis. The results of this investigation do not support the hypothesis that prostaglandins function as general modulators of hormonal actions which are mediated by cyclic AMP. PMID- 4339887 TI - Monoamine oxidase in sympathetic nerves: a transmitter specific enzyme type. AB - 1. When rat brain or superior cervical ganglion monoamine oxidase was incubated with increasing concentrations of clorgyline, using tyramine as substrate, the inhibition of the enzyme could be represented by a pair of sigmoidal curves joined by a horizontal region where inhibition was constant. Tyramine appeared to be metabolized by two enzymes, one of which was highly sensitive to clorgyline, designated A, whereas the other enzyme, designated B, was less sensitive to clorgyline.2. The ratio of A/B activity for brain was 6/4 while in the ganglion it was 9/1.3. When the experiments were repeated using noradrenaline as the substrate, the inhibition of the enzyme followed a simple sigmoidal curve where deamination was inhibited by low concentrations of clorgyline as observed with enzyme A.4. We conclude that tyramine is deaminated by both A and B enzymes whereas noradrenaline is deaminated only by enzyme A, the enzyme which is most active in the ganglion. Our observations are consistent with the hypothesis that a specific intraneuronal monoamine oxidase plays an important role in the catabolism of noradrenaline in sympathetic nerves. PMID- 4339886 TI - Effect of prolonged treatment with tetracosactrin on hypothalamo-pituitary adrenal function in the rat. AB - 1. The functional integrity of the hypothalamo-pituitary adrenal (HPA) system was assessed in rats after prolonged treatment with tetracosactrin.2. Adrenal size and sensitivity to corticotrophin were increased.3. Both the circadian rhythm and the stress-induced increase in HPA activity were inhibited. The circadian rhythm recovered before the response to stress.4. Tetracosactrin given after betamethasone treatment delayed the return of a normal HPA response to stress.5. Suppression of HPA activity appeared to be the result of a direct action of tetracosactrin and not entirely due to the elevations in the plasma corticosterone concentration which it caused. PMID- 4339888 TI - Increased concentrations of cyclic 3',5'-adenosine monophosphate without a physiological response after antidiuretic hormone. AB - Treatment of the serosal surface of the isolated bladders of toads (Bufo marinus) with phospholipase C inhibited the hydro-osmotic response to ADH, but did not prevent the rise in cyclic AMP concentrations associated with hormone action. PMID- 4339889 TI - [Action of phosphodiesterase inhibitors on electric discharge of the electroplax isolated from Electrophorus electricus (L.)]. PMID- 4339890 TI - [Study of the transient ferriperoxidase-dihydrofumaric acid complex at low temperatures]. PMID- 4339891 TI - [Influence of quartz, carbon, titanium oxide and asbestos dusts on the experimental disease in mice induced with Chlamydia psittaci]. PMID- 4339892 TI - Adenyl cyclase activity in the perfused rat heart made to fail by substrate-lack. PMID- 4339893 TI - Left ventricular akinesis: experimental production, haemodynamic effects, and results of excision. PMID- 4339894 TI - Relationship between arterial pressure and the permeability of arterioles to carbon particles in acute hypertension in the rat. PMID- 4339895 TI - Scanning electron microscopy of cells in culture. PMID- 4339896 TI - Gap junctions in normal and transformed fibroblasts in culture. PMID- 4339897 TI - Polar lobe formation by embryos of Ilyanassa obsoleta. Effects of inhibitors of microtubule and microfilament function. PMID- 4339898 TI - Volume control. PMID- 4339899 TI - The effects of dieldrin on the subcellular structure and function of mammalian liver cells. PMID- 4339900 TI - The value of the mouse in carcinogenicity testing. PMID- 4339901 TI - The actions of dibutyryl cyclic adenosine 3',5'-monophosphate and methyl xanthines on pancreatic exocrine secretion. AB - 1. The effects of dibutyryl cyclic adenosine 3',5'-monophosphate (dibutyryl cyclic AMP) and theophylline have been tested in the stimulated and unstimulated perfused cat pancreas.2. Dibutyryl cyclic AMP (1.0 mM) elicited the secretion of water and electrolytes, but not of enzymes, from this preparation. The composition of this secretion was the same as that secreted in response to secretin. This response could be slightly potentiated by theophylline.3. Theophylline, theobromine and caffeine all markedly potentiated submaximal secretin stimulation, the relative effectiveness of these methyl xanthines being the same as that observed in the inhibition of pure phosphodiesterase prepared from beef heart.4. At high concentration, theophylline had two effects: it was capable of initiating electrolyte and water secretion alone (whilst having only a very small stimulatory effect on enzyme secretion); it also had an inhibitory effect on secretion stimulated maximally by secretin.5. Thus it was easy to mimic the action of secretin, but not pancreozymin, using dibutyryl cyclic AMP and theophylline. This suggests that the action of secretin, but not that of pancreozymin, may be mediated through cyclic AMP. Further evidence is, however, needed before these conclusions can be made with confidence. PMID- 4339902 TI - Cyclic adenosine 3',5'-monophosphate concentration in the pancreas following stimulation by secretin, cholecystokinin-pancreozymin and acetylcholine. AB - 1. Following an I.V. injection of secretin into anaesthetized cats, the pancreatic cyclic AMP concentration rose within 30 sec and reached near-maximal values within 1 min. Pancreatic secretion began only after 45 sec. As secretion declined, the cyclic AMP concentration also fell. However, after 40 min, when secretion had ceased, the concentration again rose, reaching a maximum after about 80 min and returned to basal values within 140 min.2. During secretin infusion the pattern of cyclic AMP changes was the same, except that the initial rise was maintained as long as secretin was infused.3. Following either pancreozymin or acetylcholine, alone or super-imposed on secretin stimulation, similar changes in cyclic AMP concentration were observed. However, the initial rise lasted only 30 sec, basal concentrations being approached within 1 min, and was accompanied by enzyme secretion. The concentration of cyclic AMP subsequently rose and fell again, in the absence of enzyme secretion, exactly as after secretin stimulation.4. Similar observations were made using an isolated, saline perfused preparation of the cat's pancreas.5. By using very low doses of pancreozymin it was possible to observe the first rise in cyclic AMP concentration in the absence of enzyme secretion. Similarly atropine, while blocking enzyme secretion, did not affect the rise in cyclic AMP concentration after acetylcholine. The second increase in concentration was never associated with secretion (it may have been connected with the synthesis of exportable enzymes by the gland).6. While these observations suggest that cyclic AMP may be involved in the response of the pancreas to secretin, pancreozymin and acetylcholine, no simple relation exists between cyclic AMP concentration and secretion. PMID- 4339903 TI - Heat production and fluorescence changes of toad sartorius muscle during aerobic recovery after a short tetanus. AB - 1. The time course of the aerobic recovery following a 0.5 sec tetanus at 20 degrees C of the sartorius muscle of the toad Bufo bufo, equilibrated in bicarbonate-CO(2) Ringer solution, has been followed by recording simultaneously the heat production and the fluorescence excited by ultra-violet light at 366 nm.2. The fluorescence light emitted in these conditions in the region of 450 nm monitors the state of oxidation-reduction of the nicotinamideadenine dinucleotides (NAD(+)-NADH). After a short tetanus, the cycle evoked consists of an initial increase of the fluorescence (reduction of NAD(+)) followed by a long lasting phase of decreased light emission. This includes an early period of oxidation of NADH succeeded by a slow reduction of the NAD(+) formed in excess over the resting state. After iodoacetate, the initial reduction is suppressed.3. The time course of both fluorescence and heat production may be analysed into a rapid and a slow component by a double exponential model.4. The time courses of the aerobic recovery heat and of the fluorescence changes are similar after five minutes, but differ in their fast components. IAA significantly increases the rate constants of the fast terms of both monitors.5. The slow component is mainly related to aerobic processes while the fast one is due to both oxidative and glycolytic reactions occurring simultaneously. PMID- 4339905 TI - [Specificity of -fetoprotein of primary hepatoma]. PMID- 4339904 TI - The uptake and hydrolysis of p-nitrophenyl phosphate by red cells in relation to ATP hydrolysis by the sodium pump. AB - 1. The hydrolysis of p-nitrophenyl phosphate has been studied in human red cells, ghosts and haemoglobin-free membranes to see whether hydrolysis was related to the functioning of the sodium pump.2. The cell membrane restricted p-nitrophenyl phosphate entry into cells and was rate-limiting for hydrolysis by the large amount of intracellular soluble phosphatase. The uptake was inversely proportional to the external chloride concentration, and inhibitors (phloretin and persantin) of inorganic phosphate uptake also reduced p-nitrophenyl phosphate uptake and hydrolysis. The entry mechanism of p-nitrophenyl phosphate appears to be similar to that of inorganic phosphate.3. p-Nitrophenyl phosphate was hydrolysed in cells almost entirely by ouabain-insensitive phosphatases, both soluble and membrane bound. In ghosts containing less soluble enzyme than cells there was still no component of p-nitrophenyl phosphate hydrolysis that was related to the sodium pump in being sensitive to external potassium or ouabain.4. Haemoglobin-free membranes lacking soluble p-nitrophenyl phosphatase required potassium for optimum p-nitrophenyl phosphate hydrolysis and this part was inhibited by ouabain as was also ATP hydrolysis by the sodium pump. The rates of potassium-dependent and potassium-independent hydrolysis were each increased about threefold on decreasing the electrolyte concentration from 150 to 25 mM. The response was found whether the main electrolyte was potassium chloride, sodium chloride, choline chloride or Tris chloride. In contrast, the changes were not found when the osmotic pressure was varied to the same extent with non electrolytes. p-Nitrophenyl phosphate hydrolysis was thus activated on lowering the ionic strength. The soluble enzyme was similarly affected and the effect was reversible.5. The membrane ATPase activity was unaffected by the changes in ionic strength which markedly altered p-nitrophenyl phosphate hydrolysis.6. These results with red cell membranes show that the ionic strength under physiological conditions largely prevents the hydrolysis of p-nitrophenyl phosphate, but not of ATP. A possible mechanism is discussed in terms of the effect of different structures of water in electrolyte and non-electrolyte solutions on the enzymic activity of the sodium pump. PMID- 4339906 TI - [Clinicopathological examination of -fetoprotein and hepatoma]. PMID- 4339907 TI - [Analysis of -fetoglobulin in early diagnosis and screening of liver cancer]. PMID- 4339908 TI - [Intra-arterial chemotherapy of primary hepatoma and changes in -fetoprotein levels]. PMID- 4339909 TI - [Future problems in the research of -fetoprotein]. PMID- 4339910 TI - [Detection of -fetoprotein and its clinical significance]. PMID- 4339911 TI - [3 cases of reticuloendothelial diseases with diagnostic difficulty]. PMID- 4339912 TI - The Synacthen test in depressive illness. PMID- 4339914 TI - [Role of adenoviruses in the etiology and pathogenesis of chronic tonsillitis and adenoiditis]. PMID- 4339913 TI - [60-Cobalt teletherapy of malignant tumors in childhood. Experiences and therapeutic results]. PMID- 4339915 TI - [Some neoplasms of otorhinolaryngological localization]. PMID- 4339917 TI - [Studies on uptake and metabolism of phosphate compounds by phosphate deficient cells of Candida utilis. II. Pyrophosphatase activity of the cells]. PMID- 4339916 TI - [Diazoxide treatment of infantile hypoglycaemia]. PMID- 4339918 TI - [Autofluorescent granules in the ependyma of the recessus inframamillaris of the yellow spiny mouse (Acomys cahirinus dimidiatus)]. PMID- 4339919 TI - Nature and significance of spontaneous degeneration of axons in the pyramidal tract. PMID- 4339920 TI - An electron microscopic study of the normal synaptic relationships and early degenerative changes in the rat olfactory tubercle. PMID- 4339921 TI - Ultrastructural features of the lateral preoptic area, median eminence and arcuate nucleus of the rat. PMID- 4339922 TI - [Ultrastructural equivalents of cellular autophagy. Electronmicroscopy observations on spermatids of Eisenia foetida during the cytoplasmic reduction]. PMID- 4339923 TI - Salivary gland adenomas of the palate. PMID- 4339924 TI - Transport of ferritin across Reissner's membrane. PMID- 4339925 TI - Convergence on interneurones in the reciprocal Ia inhibitory pathway to motoneurones. PMID- 4339926 TI - Animal model for human disease. Hydranencephaly, porencephaly, cerebral cysts, retinal dysplasia, CNS malformations. Animal model: bluetongue-vaccine-virus infection in fetal lambs. PMID- 4339927 TI - Bone scanning. Its value in the preoperative evaluation of patients with suspicious breast masses. PMID- 4339928 TI - Clinical role of serum gastrin measurements in the Zollinger-Ellison syndrome. PMID- 4339929 TI - [Structure of amino acids in ristomycin: amino acids B and C]. PMID- 4339930 TI - [Studies on free amino acids of Proact.fructiferi var. ristomycin-producing ristomycin]. PMID- 4339931 TI - The combustion of alcohol and its inhibition by 4-methyl-pyrazole in perfused rat livers. PMID- 4339932 TI - Turnover of inositol and phosphorus containing lipids in Saccharomyces cerevisiae; extracellular accumulation of glycerophosphorylinositol derived from phosphatidylinositol. PMID- 4339933 TI - Properties and use of an antiserum to cytochrome oxidase from baker's yeast. PMID- 4339934 TI - A mitochondrial phosphoenolpyruvate carboxykinase from rat brain. PMID- 4339935 TI - Energy-linked reactions in photosynthetic bacteria. VII. Inhibition of NAD + reduction by phenethylbiguanide. PMID- 4339936 TI - Isolation of ahighly active fructose diphosphatase from rabit muscle: its subunit structure and activation by monovalent cations. PMID- 4339937 TI - Activation of rabbit muscle fructose diphosphatase by EDTA and the effect of divalent cations. PMID- 4339938 TI - Manganese transfer into the bile in rats. PMID- 4339940 TI - Van Buchem's disease (hyperostosis corticalis generalisata familiaris). A case report. PMID- 4339939 TI - Malignant granuloma. PMID- 4339942 TI - The ultrastructure of the epiphyseal plate. II. The hypertrophic chondrocyte. PMID- 4339941 TI - The ultrastructure of the epiphyseal plate. I. The flattened chondrocyte. PMID- 4339943 TI - The hemicelluloses of bracken. II. A galactoglucomannan. PMID- 4339944 TI - Biosynthesis of alginate. 3. Tritium incorporation with polymannuronic acid 5 epimerase from Azotobacter vinelandii. PMID- 4339945 TI - Structures of the galactomannans from seeds of Annona muricata, Arenga saccharifera, Cocos nucifera, Convolvulus tricolor, and Sophora japonica. PMID- 4339946 TI - Pyrimidine nucleosides of the furanose form of 2-amino-2-deoxy-D-xylose. PMID- 4339947 TI - A paramagnetic resonance method for detection of copper in cellulose. PMID- 4339948 TI - Relationship between hormonal control and physical activity. I. Effect of corticotropin and dexamethasone on physical activity in rats. PMID- 4339949 TI - The binding of oxidized and reduced nicotinamide adenine-dinucleotide to yeast glyceraldehyde-3-phosphate dehydrogenase. PMID- 4339950 TI - Studies on succinate dehydrogenase. Site of attachment of the covalently-bound flavin to the peptide chain. PMID- 4339951 TI - Studies on succinate dehydrogenase. 8 -Histidyl-FAD as the active center of succinate dehydrogenase. PMID- 4339954 TI - Relative stability of hetacillin and ampicillin in solution. PMID- 4339952 TI - [Tuberculostatics. General adverse effects]. PMID- 4339953 TI - Virological studies of sudden, unexplained infant deaths in Glasgow 1967-70. AB - Virus isolation tests on 72 sudden unexplained infant deaths and 34 cases of explained death showed that 42 and 29% respectively had virus infections. A wide range of viruses was encountered, mainly enteroviruses and adenoviruses, mostly from bowel specimens. The findings did not suggest that overwhelming virus infection was a common feature of sudden death in infancy. PMID- 4339955 TI - Constrictor and compliance responses of some arteries to nerve or drug stimulation. AB - 1. The magnitude of the maximum constrictor response to nerve stimulation was measured in the saphenous, ear, inferior and superior mesenteric, renal and carotid arteries in the rabbit and corresponding arteries, except the ear and carotid, in the guinea-pig. The responses varied from an average rise of 350 mm Hg in the rabbit saphenous to almost no response in the rabbit carotid. The guinea-pig arteries gave consistently smaller responses than the rabbit. The response magnitude was unrelated to wall thickness or the presence of an active uptake mechanism for noradrenaline. The response did correlate with the density of adrenergic innervation, with the wall thickness to lumen ratio and with the function of the artery and the amount of connective tissue in its wall.2. The magnitude of the maximum constrictor response to noradrenaline and six other agonist drugs, acetylcholine, histamine, 5-HT, KCl, vasopressin and angiotensin II, was compared. In all arteries noradrenaline was the most powerful agonist. The maximum responses to nerve stimulation and to noradrenaline were compared. In the rabbit saphenous and ear arteries this ratio was almost 1, but in arteries such as the rabbit renal it fell below 0.5.3. Artery wall stiffness was measured from the pressure/volume relationship during distension of a closed length of artery. In a relaxed artery two components only were present, an early easily distended phase and a late relatively undistensible phase. Noradrenaline caused a third, early, very stiff phase to appear in the pressure/volume curves. This is probably due to contracted muscle. The increase in stiffness varied from 617% in the rabbit saphenous to 152% in the rabbit carotid. In conducting arteries such as the carotid the change in stiffness was a more sensitive index of noradrenaline action than vaso-constriction.4. During the measurement of wall stiffness stress relaxation was not noticeable in relaxed arteries but was prominent in arteries contracted by noradrenaline. Stress relaxation involved both the changes in wall stiffness and the ability to constrict and was reversible even in the continuing presence of agonist drugs.5. Nerve stimulation, even in arteries where its vasoconstrictor effects were equal to those of noradrenaline, gave only slight increases in artery wall stiffness, suggesting that even in these densely innervated arteries only a small fraction of the muscle is activated by nerve stimulation. PMID- 4339956 TI - Influence of nitrogen dioxide on the uptake of parainfluenza-3 virus by alveolar macrophages. PMID- 4339957 TI - [Humoral mechanisms governing pathogenesis of nephrogenic hypertension and the sympatico-adrenal system]. PMID- 4339958 TI - [Changes in the serum protein antigenic properties in Botkin's disease]. PMID- 4339959 TI - [Differential diagnosis significance of guanine deaminase test in Botkin's disease]. PMID- 4339960 TI - Poly A associated with SV40 messenger RNA. PMID- 4339961 TI - Cyclic AMP and calcium in relaxation in intestinal smooth muscle. PMID- 4339962 TI - Changes in interhemispheric amplitude relationships in the EEG during sleep. PMID- 4339963 TI - [Wound healing and collagen metabolism]. PMID- 4339964 TI - [Effect of collagenase on the necrolysis of burn wounds delayed by antibiotic therapy]. PMID- 4339965 TI - The preparation of amoebic extracts and their testing by complement fixation against clinically proved sera. PMID- 4339966 TI - Non-filarial elephantiasis in Ethiopia. Analytical study of inorganic material in lymph nodes. PMID- 4339967 TI - Virulence of Entamoeba histolytica. PMID- 4339968 TI - Results of pleoptic treatment. Primary results of 412 patients and late results of 375 patients. PMID- 4339969 TI - Older persons after hospitalization: a controlled study of home aide service. PMID- 4339970 TI - Streptococcal utilization of lactic acid and its effect on pH. PMID- 4339971 TI - Pathogenicity of human oral strains of haemophili: enzymes, anaerobiosis and effects on mice and rabbits. PMID- 4339972 TI - Entrapment neuropathy of the posterior interosseous nerve. A complication of rheumatoid arthritis. PMID- 4339974 TI - Hormonal responses to synthetic luteinizing hormone and follicle stimulating hormone-releasing hormone in man. AB - The effects of the gonadotrophin-releasing hormone, synthetic decapeptide luteinizing hormone/follicle stimulating hormone-releasing hormone (LH/FSH-RH), have been studied in 18 normal men and five women in the follicular phase of their menstrual cycle. Rapid and dose-dependent (25 to 100 mug) increases in serum immunoreactive LH were seen, which reached a peak 20 to 30 minutes after a rapid intravenous injection. Similar but much smaller increases in serum immunoreactive FSH were seen. These conclusions have been validated by using two different immunoassay systems for each hormone. The LH/FSH-RH therefore causes both LH and FSH release in man as in animals but does not affect growth hormone, thyrotrophin, or ACTH. The gonadotrophin responses were the same in the women as in the men but were insufficient in the men to cause statistically significant changes in the serum levels of the gonadal steroid hormones, testosterone or oestradiol, or in their precursors 17 alpha-hydroxyprogesterone or progesterone. In the women, however, there was a rise in oestradiol after the 100-mug doses. The use of LH/FSH-RH will provide an important test to define the level of the lesion in hypogonadal patients and also should be valuable in the treatment of some types of male and female infertility. A simple and clinically useful LH/FSH RH test of pituitary function is described (100 mug given intravenously), and the provisional normal responses of LH and FSH at 20 and 60 minutes are given. PMID- 4339973 TI - Role of vegetarianism, smoking, and hydroxocobalamin in optic neuritis. AB - Only 20 patients with optic neuritis of unknown aetiology could be collected in Bombay over a period of two and a half years. Only six of them were smokers and only three (one a non-smoker) had bilateral centrocaecal scotomata similar to those found in tobacco amblyopia. In 11 untreated patients the serum vitamin B(12) and plasma thiocyanate levels were estimated and found to show no significant differences from those in normal control subjects. Treatment with hydroxocobalamin in the majority of cases and with cyanocobalamin, corticotrophin, or prednisolone in the rest showed equally good results; spontaneous improvement was seen in one case.No significant role could be assigned to smoking (cyanide) or to vegetarianism in the production of optic neuritis in these patients; nor was there any evidence of depletion of total (cyanide-extracted) B(12) or of an increase in the proportion of non-cyanide extracted B(12) in the serum. PMID- 4339975 TI - Metastatic calcification and dialysis. PMID- 4339976 TI - Trapped nerves. PMID- 4339977 TI - Alpha-fetoprotein and gastric carcinoma. PMID- 4339978 TI - [Detection of avian myeloblastosis virus in chicken fibroblast cultures treated with DNA from virus-producing leukemic cells]. PMID- 4339979 TI - [Radioresistance of the murine mammary tumor virus subjected to gamma irradiation]. PMID- 4339980 TI - The radiological features of Wilms' tumour. PMID- 4339981 TI - Phlebo-arterio-urography in the diagnosis of abdominal masses in children. PMID- 4339982 TI - Calcitonin clearance in the pig and in the isolated perfused pig liver. PMID- 4339983 TI - Comparison of the effects of various agents on thyroidal adenyl cyclase activity with their effects on thyroid hormone release. PMID- 4339984 TI - Popliteal pterygium syndrome. Evidence for a severe autosomal recessive form. PMID- 4339985 TI - [Microphysiological data on heterosegmental and heterosensorial controls of the transmission of cutaneous afferences at the lumbar level in cats]. PMID- 4339986 TI - [Effect of adrenalectomy and A.C.T.H. or hydrocortisone on norepinephrine content in the rat hypothalamus]. PMID- 4339987 TI - [Study in utero, in chronic condition, of wakefulness in guinea-pigs]. PMID- 4339988 TI - [Effects on renal and femoral vascular resistances of simultaneous perfusions of angiotensin and catecholamines]. PMID- 4339989 TI - [Modifications of the unit activity of dorsal horn neurons of the spinal cord under the effect of intra-arterial injection of bradykinin at the level of the hindlimb in cats]. PMID- 4339990 TI - [Neuromuscular transmission after gangliectomy in crayfish]. PMID- 4339991 TI - [Study of a plasma factor binding angiotensin II]. PMID- 4339992 TI - [Hormonal regulation of lipolysis in ducks]. PMID- 4339993 TI - [Lipolytic action of ACTH, catecholamines and hydrocortisone on isolated adipose cells in normal and adrenalectomized rabbits]. PMID- 4339995 TI - [Unit activity of neurons of associative visual cortex during wakefulness and sleep in young Macaca speciosa]. PMID- 4339994 TI - [Control of hypophyseal corticotropic activity by the hypothalamus, in green frogs, Rana esculenta L]. PMID- 4339997 TI - [Electronic stimulation, a means of study of the behavior of neurons and their network]. PMID- 4339996 TI - [Study of a brief-latency response in the vestibulo-ocular pathways]. PMID- 4339998 TI - [Comparative study of nerve potentials and description of a method of discrimination]. PMID- 4339999 TI - [Persistence of vago-aortic sleep after surgical and pharmacological destruction of the raphe nuclei]. PMID- 4340000 TI - Uterine collagenase and collagen in young and ageing rabbits. PMID- 4340001 TI - The effect of maternal respiratory disease induced by para-influenza type 1 (Sendai) virus on foetal development and neonatal mortality in the rat. PMID- 4340002 TI - [Genetic material of herpesviruses. I. Biophysical-chemical characterization of herpesvirus DNAs]. PMID- 4340004 TI - Effect of polymyxin B on the replication of poliovirus in cell cultures. PMID- 4340005 TI - Importance of postherapeutic follow-up studies and supervision of cancer patients. PMID- 4340006 TI - [Granular cell myoblastoma of the oral cavity]. PMID- 4340003 TI - [Genetic material of herpesviruses. II. Genetic relatedness of various herpesviruses]. PMID- 4340007 TI - Disorders of the auditory apparatus caused by embryopathy or foetopathy: prophylaxis and treatment (a) deafness as a result of congenital malformations occurring during the first three months (b) deafness resulting from diseases of the foetus occurring after the fourth month. PMID- 4340008 TI - [Malignant abdominal tumors in pediatrics (with special reference to Wilms' tumor and neuroblastoma)]. PMID- 4340009 TI - A comparative study of the latex agglutination and gel diffusion precipitin test in the diagnosis of amebic liver abscess. PMID- 4340011 TI - Brainstem sites for activation of vagal cardioaccelerator fibers in the dog. PMID- 4340010 TI - Secretagogue-induced tachyphylaxis of gastric H + secretion and its reversal. PMID- 4340012 TI - Body temperature and adrenal function in cold-exposed hypothalamic-disconnected rats. PMID- 4340013 TI - Hepatic changes in renin substrate biosynthesis and alkaline phosphatase activity in the rat. PMID- 4340014 TI - Control of deoxycorticosterone secretion in the dog. PMID- 4340015 TI - Neurogenic hypercholesterolemia. II. Relationship to endocrine function. PMID- 4340016 TI - Heights, weights, and skeletal age of Jamaican adolescents with sickle cell anaemia. PMID- 4340017 TI - Effects of fetal exposure to diazoxide in man. PMID- 4340020 TI - Night and day growth hormone levels during treatment with corticosteroids and corticotrophin. PMID- 4340018 TI - Growth and bone age of juvenile diabetics. PMID- 4340021 TI - Cytomegalovirus mononucleosis in Chinese infants. PMID- 4340019 TI - Cushing's syndrome in childhood: postoperative management. PMID- 4340022 TI - Familial hypobetalipoproteinaemia. PMID- 4340023 TI - Metabolism of Spirochaeta aurantia. II. Aerobic oxidation oxidation of carbohydrates. PMID- 4340024 TI - Inorganic pyrophosphate in human parotid saliva and dental plaque. PMID- 4340025 TI - In-vitro effect of fluoride on lipid synthesis by rat calvaria. PMID- 4340026 TI - Degradation products from human serum high density lipoproteins following dehydration by rotary evaporation and solubilization. PMID- 4340027 TI - Studies of the metal sites of copper proteins. IV. Stellacyanin: preparation of apoprotein and involvement of sulfhydryl and tryptophan in the copper chromophore. PMID- 4340028 TI - Further purification and properties of Hageman factor cofactor. PMID- 4340030 TI - [Errors in after care of conservative fracture treatment]. PMID- 4340031 TI - [Fractures of the hand region--avoidance of failures]. PMID- 4340029 TI - Hypocalcemia, hypomagnesemia and hypokalemia during chemotherapy of pulmonary tuberculosis. PMID- 4340032 TI - Competition for receptors for immunoglobulin on cytotoxic lymphocytes. PMID- 4340033 TI - REM sleep inhibition by light in the albino rat. PMID- 4340034 TI - [Nonchromaffin paraganglioma in the peritoneum of the urinary bladder]. PMID- 4340036 TI - Hibernoma. An electron microscopic study. PMID- 4340035 TI - Ultrastructure of the adrenal zona glomerulosa in children with renovascular hypertension. PMID- 4340037 TI - Ultrastructural observations of a chordoma arising in the clivus. PMID- 4340038 TI - The vitamin K derivatives of some skin-mucins. 3. A route of oxygen transfer. PMID- 4340039 TI - Melkersson-Rosenthal syndrome: review of literature and report of case. PMID- 4340040 TI - [Brain tumors]. PMID- 4340042 TI - Some characteristics of nocturnal penile tumescence during puberty. PMID- 4340041 TI - [Subglottic cylindroma]. PMID- 4340043 TI - Vitamin D-dependent rickets: actions of parathyroid hormone and 25 hydroxycholecalciferol. PMID- 4340044 TI - The dizzy patient. PMID- 4340045 TI - On the presence of a variant form of instinctual regression. Oral drive cycles in obesity-bulimia. PMID- 4340046 TI - Essential myoclonus in infancy. PMID- 4340047 TI - Effects of corticosterone on nuclear and mitochondrial DNA-dependent protein synthesis of adrenocortical cells of hypophysectomized ACTH-treated rats. PMID- 4340048 TI - [Surgical technics in the treatment of breast carcinomas]. PMID- 4340049 TI - Brain tumors in irradiated monkeys. PMID- 4340051 TI - Neuropathologic effects of proton-beam irradiation in man. I. Dose-response relationships after treatment of intracranial neoplasms. PMID- 4340050 TI - [Permeability disorders in the central nervous system of the pig. Ultrastructure of cerebrospinal angiopathy]. PMID- 4340052 TI - Three variants of foot-and-mouth disease virus type O: cell culture characteristics and antigenic differences. PMID- 4340053 TI - Three variants of foot-and-mouth disease virus type O: agar gel diffusion reactions. PMID- 4340054 TI - Three variants of foot-and-mouth disease virus type O: exposure of cattle. PMID- 4340055 TI - Acute effect of endotoxin on selected enzymes in the guinea pig. PMID- 4340056 TI - Certain characteristics of herpesvirus saimiri cultured in subhuman primate culture cells. PMID- 4340057 TI - Tilting rack for cell cultures during replication of foot-and-mouth disease virus. PMID- 4340058 TI - Menadiol as an electron donor for reversed oxidative phosphorylation in submitochondrial particles. PMID- 4340059 TI - Relation of unsaturated fatty acid composition of rat liver mitochondria to oscillation period, spin label motion, permeability and oxidative phosphorylation. PMID- 4340060 TI - Evidence for the role of a bound ferredoxin as the primary electron acceptor of photosystem I in spinach chloroplasts. PMID- 4340061 TI - Properties of a nitrate reductase of Chlorella. PMID- 4340063 TI - A morphometric analysis of human breast carcinoma. AB - A method for determining the tumour cell content of breast neoplasms by morphometry is described.The mean total tumour cell volume of 10 scirrhous carcinomata was 287.6 mm(3), or 21.5% of the entire neoplasm. Two medullary lesions gave a mean tumour cell volume of 417 mm(3), 64.5% of the total volume of the neoplasm.A possible extension of this technique to monitor changes in the character of malignant tumours is discussed. PMID- 4340062 TI - A comparative study of the proteins of rat plasma, liver and hepatoma by agarose immunoelectrophoresis. AB - A convenient and selective microtechnique, agarose immunoelectrophoresis, was applied to a comparison of the antigens in rat liver and plasma, and in primary hepatoma induced in male Fischer strain rats with N-2-fluorenylacetamide or N hydroxy-N-2-fluorenylacetamide. Of the many soluble proteins antigenic in this system, 3 were singled out for detailed study. The albumin in liver and hepatoma had a higher mobility than that in plasma. Extraction of the soluble fraction of rat liver with ether, or treatment with absorbing charcoal, yielded an albumin band with a mobility identical to that in plasma, suggesting that liver albumin carries absorbed molecules with electronegative charges. The transferrin arc from liver, plasma and hepatoma had identical mobility. One protein with low mobility was present in higher concentration in the soluble liver fraction of male than of female rats, but it was reduced in hepatoma of male rats. The "h(2)" proteins of liver were found in the cathodic region as 5 arcs, some of which were reduced, while others were not detectable in hepatoma. PMID- 4340065 TI - Gene fusion. PMID- 4340064 TI - His4 a gene complex of Saccharomyces cerevisiae. PMID- 4340066 TI - The use of solid-medium cultures in chemotherapeutic experiments in vitro with Entamoeba histolytica. PMID- 4340067 TI - Inactivation rate of variola virus in the infected CAM exposed to some germicides. PMID- 4340068 TI - [Harmful effects of common drugs on the visual apparatus. Hormones. I. ACTH and glucocorticoids]. PMID- 4340070 TI - [Harmful effects of common drugs on the visual apparatus. Anthelmintics]. PMID- 4340069 TI - [Harmful effects of common drugs on the visual apparatus. Anti-infective drugs. B. Antibiotics]. PMID- 4340071 TI - A re-evaluation of the mode of action of 5-hydroxytryptamine on lateral geniculate neurones: comparison with catecholamines and LSD. PMID- 4340072 TI - Effects of strychnine, bicuculline and picrotoxin on labyrinthine-evoked inhibition in neck motoneurons of the cat. PMID- 4340073 TI - The time course of conduction failure during degeneration of a central tract. PMID- 4340075 TI - [Elimination of oily contrast media administered by different routes]. PMID- 4340076 TI - [Quantitative estimation of the kinetics of free-radical processes in the organs of animals subject to hypoxia]. PMID- 4340074 TI - [Electromyographic analysis of the mechanism governing the action of curare-like agents]. PMID- 4340078 TI - The ultrastructure of lobule boundary cells and Leydig cell homologs in the testis in a cichlid fish, Cichlasoma nigrofasciatum. PMID- 4340077 TI - Hormonal control of water and sodium movements in the urinary bladder of the starry flounder, Platichthys stellatus. PMID- 4340079 TI - Effects of stanniectomy and hypophysectomy on total plasma cortisol levels in the eel (Anguilla anguilla L.). PMID- 4340080 TI - Effects of mammalian ACTH on liver and muscle glycogen levels in the South American caiman (Caiman sclerops). PMID- 4340081 TI - Plasma corticosterone levels in the male iguanid lizard Sceloporus cyanogenys under various physiological conditions. PMID- 4340082 TI - Variations in the interrenal and corpuscles of Stannius of Mugil cephalus from the Colorado River and its estuary. PMID- 4340083 TI - Macrophage-bound antigens. II. Comparison of the immunogenicity of antigens bound to macrophages, lymphocytes, thymocytes and hepatoma cells. PMID- 4340084 TI - Differentiation of type 1 and type 2 herpes simplex virus by in vitro stimulation of immune lymphocytes. PMID- 4340085 TI - Primary signet ring cell carcinoma of the bladder: report of a case and review of the literature. PMID- 4340086 TI - Viral studies in patients with non-specific prostatourethritis. PMID- 4340087 TI - Endodermal sinus tumors of the testis in infants and children. PMID- 4340088 TI - [Sequels and complications of peripheral nerve lesions]. PMID- 4340089 TI - Partial suppression of tumour production by dibutyryl cyclic AMP and theophylline. PMID- 4340090 TI - Early stages of Rous virus action on sensitive and resistant cells. PMID- 4340091 TI - Assay of corticotrophin releasing factor (CRF) in ACTH-primed 'grafted' rats. PMID- 4340092 TI - Adrenocortical function and the glucocorticoids. PMID- 4340093 TI - The minimum protective dose of the herpesvirus turkeys vaccine against Marek's disease. PMID- 4340095 TI - [Krukenberg's tumor--metastatic ovarian carcinoma]. PMID- 4340094 TI - The uptake, metabolism and release of 14C-taurine by rat retina in vitro. PMID- 4340096 TI - Microglial reactions following thermal necrosis of the rat cortex: an electron microscope study. PMID- 4340097 TI - [Virus-like filaments and crystalloid inclusions in a case of "primary" reticuloendotheliosis of the brain]. PMID- 4340098 TI - Ultrastructure of Hirano bodies. PMID- 4340099 TI - A study of rod-like structures (Hirano bodies) in 240 normal and pathological brains. PMID- 4340100 TI - Cancer incidence in Finland, Iceland, Norway and Sweden. A comparative study. PMID- 4340101 TI - The concept of benign metastasizing hydatidiform moles. PMID- 4340103 TI - [Arteriography in Wilms' tumours and its relationship to renal dysplasia. A preliminary communication]. PMID- 4340102 TI - [Acute laryngotracheobronchitis (croup): correlation of clinical severity with radiologic and virologic findings]. PMID- 4340104 TI - [Determination of ampicillin, cephalexin and related compounds by formol titration. 7. Condensated acetidinones]. PMID- 4340105 TI - Multiple forms of phosphofructokinase in rat tissues and rat tumors. PMID- 4340106 TI - Thyroxine modulation of epinephrine stimulated secretion of rat parotid amylase. PMID- 4340107 TI - Changes in some biochemical parameters including cytochrome P-450 after hypophysectomy and their restoration by ACTH administration in rats four months post hypophysectomy. PMID- 4340109 TI - Non-linear relation between oxygen-binding and structural changes of hemoglobin. PMID- 4340108 TI - Effects of actinomycin D on hormone-induced steroidogenesis by superfused rat adrenal glands. PMID- 4340110 TI - Cell surface glycosyl transferases and acceptors in normal and RNA- and DNA-virus transformed fibroblasts. PMID- 4340111 TI - An ATP pool with rapid turnover within the cell membrane. PMID- 4340112 TI - A UV-specific endonucleolytic activity present in human cell extracts. PMID- 4340113 TI - The requirement for membrane integrity in the inhibition of hepatic glucose 6 phosphatase by sulfhydryl reagents and taurocholate. PMID- 4340114 TI - Human erythrocyte phosphofructokinase: its purification and some properties. PMID- 4340115 TI - Studies on 5'-nucleotidases of rat liver. PMID- 4340116 TI - Substrates for cytochemical demonstration of enzyme activity. V. Kinetics of the hydrolysis of thymidine 3'-(5-bromo-4-chloroindol-3-yl) phosphate by phosphodiesterase II. PMID- 4340117 TI - Angiotensin-converting enzyme and a second dipeptidyl carboxypeptidase from hog plasma. PMID- 4340118 TI - The isolation and kinetics of penicillin amidase from Escherichia coli. PMID- 4340119 TI - The effect of glass and silica surfaces on trypsin and -chymotrypsin kinetics. PMID- 4340120 TI - Water-insoluble enzymes for peptide sequencing: dipeptidyl aminopeptidase I (cathepsin C), an enzyme with subunit structure. PMID- 4340121 TI - Possible regulatory characteristics of the fructose diphosphatase- phosphoribulokinase complex from Rhodospirillum rubrum. PMID- 4340123 TI - [Fluorescent method of study of the respiratory metabolism of working organs]. PMID- 4340122 TI - Uridine diphosphoglucose dehydrogenase from rat liver: purification and effect of pH on regulatory properties. PMID- 4340124 TI - [Role of endocrine mechanisms in the development of atherosclerosis]. PMID- 4340125 TI - [Characteristics of fat-lipoid metabolism in experimental athyreosis and hypothyroidism in rats]. PMID- 4340127 TI - [Activity of monoamine oxidase and diamine oxidase in a culture of chick fibroblasts infected with Rous sarcoma virus]. PMID- 4340128 TI - [Enzymes interventing in the metabolism of fibrous proteins of connective tissue]. PMID- 4340126 TI - [Determination of free amino acid composition and enzyme activity of human nasal polyps in conditions of stimulation of serotonin biosynthesis]. PMID- 4340129 TI - Metabolic and pharmacologic interaction of ethanol and metronidazole in the rat. PMID- 4340130 TI - The effect of temperature changes on tachyphylaxis to angiotensin in vitro. PMID- 4340131 TI - Relation between drug-metabolizing activity and phospholipids in hepatic microsomes. I. Effects of phenobarbital, carbon tetrachloride, and actinomycin D. PMID- 4340132 TI - Structure of a -D-glucan from the mycelial wall of Basidiomycete QM 806. PMID- 4340133 TI - Mutations affecting meiosis in Podospora anserina. I. Cytological studies. PMID- 4340134 TI - Calcification of cartilage. PMID- 4340136 TI - [Fluorographic study on the influence of lacrimal gland tumors on the ocular fundus]. PMID- 4340135 TI - The hyperlipidemias and coronary artery disease. PMID- 4340137 TI - Metabolic evaluation of sexual dimorphism. 3. Effect of epinephrine, dibutyryl cyclic AMP and cyclic-AMP on the energy metabolism of mice submaxillary glands. PMID- 4340138 TI - The effects of propranolol and electrical stimulation on the cyclic 3',5'-AMP content of isolated cerebral tissue. PMID- 4340141 TI - Systemic mastocytosis and multiple carcinomas. PMID- 4340140 TI - The effect of antibiotics on the in vivo synthesis of messenger ribonucleic acid from the lactose operon of Escherichia coli. PMID- 4340142 TI - [Neurophysiologic models of epilepsy]. PMID- 4340139 TI - [Kidney and hypertension]. PMID- 4340143 TI - Cholinergic effects on adrenergic neurotransmitters in rabbit brain parts. PMID- 4340144 TI - An analysis of the effect of reserpine upon ponto-geniculo-ooccipital wave activity in the cat. PMID- 4340145 TI - Facilitation of spinal synaptic transmission by catechol. PMID- 4340147 TI - The role of the cellular factor in leukemogenesis after inoculation with the Graffi virus. PMID- 4340146 TI - Prolonged oviduct retention of iodized contrast medium. PMID- 4340148 TI - Changes in the peripheral blood of mice inoculated with cell-free filtrates of Graffi virus-induced leukemias. PMID- 4340149 TI - Graffi virus-induced reticular leukemia in mouse. I. Morphologic studies. PMID- 4340150 TI - Graffi virus-induced reticular leukemia in mouse. II. Activity of acid and alkaline phosphatase and nonspecific esterase in organs. PMID- 4340151 TI - The activity of neuroglial enzymes during myelination and demyelination. PMID- 4340152 TI - Expression of fetal antigens in tumor cells. AB - The activities of sera that reacted specifically with the specific cell-surface antigens of polyoma or simian virus 40 tumors could only be inhibited by absorption of the sera with tumor cells transformed by the specific virus, and could not be removed by the absorption with cells from various fetal tissues nor with cells from other tumors. In contrasts, the antisera produced in male C3H/HeN mice by inoculation of irradiated, syngeneic fetal tissue of 1- to 2-weeks gestation, reacted with various tumor cells. The activities of these sera, when tested against cells from tumors induced by polyoma virus or simian virus 40, could also be removed by absorption with cells from tumors induced by viruses other than polyoma or simian virus 40, including leukemia cells induced by Gross virus (C58NT)D, Rauscher virus (RBL-5), and by dimethylbenzanthrene (EL. 4), and cells from mammary tumors (MM102), plasma-cell tumors (MPC-113), and fetal tissues. These results indicated that fetal antigens may be expressed in tumor cells, but they are different from tumor-specific antigens that are specific for a particular tumor or for tumors induced by a particular virus. PMID- 4340153 TI - Control of 25-hydroxycholecalciferol metabolism by parathyroid glands. AB - Thyroparathyroidectomy of rats on a diet low in calcium reduces production of 1,25-dihydroxycholecalciferol from 25-hydroxycholecalciferol to negligible levels within 40 hr, and increases production of another metabolite, called Va. Parathyroid extract, at a dose of 20 units per day, prevents these changes. When 40 units per day of parathyroid extract is given 48 hr after thyroparathyroidectomy, 1,25-dihydroxycholecalciferol production is restored almost to control levels within 36 hr. The change brought about by parathyroid extract cannot be attributed to resulting changes in serum calcium or phosphorus concentration. It appears that the parathyroid hormone serves as a tropin for production of 1,25-dihydroxycholecalciferol, the hormonal form of vitamin D responsible for calcium mobilization from intestinal contents and bone. PMID- 4340154 TI - Effect of norepinephrine on glucose metabolism in glioblastoma and neuroblastoma cells in cell culture. AB - The addition of norepinephrine to cultured glioblastoma cells results in an inhibition of uptake of radioactivity from D-[2-(3)H]glucose, D-[1-(14)C]glucose, D-[2-(14)C]glucose, and D-[6-(14)C]glucose. In addition, if the glioblastoma cells are previously labeled with these substrates, norepinephrine causes an increase in the release of radioactivity. These effects were not observed with cultured neuroblastoma cells. It is suggested that the breakdown of glycogen is activated by norepinephrine as a result of an increase in 3':5'-cyclic AMP. PMID- 4340155 TI - 2'-O-methylation of adenosine, guanosine, uridine, and cytidine in RNA of isolated rat liver nuclei. AB - Nuclei isolated from rat liver, when incubated with methyl-labeled S adenosylmethionine, incorporated label into 2'-O-methyladenosine, 2'-O methylguanosine, 2'-O-methyluridine, and 2'-O-methylcytidine of endogenous nuclear RNA. Addition of ribosomal RNA from wheat germ to the reaction markedly stimulated 2'-O-methylation of total RNA. The relative incorporation of label into the four different 2'-O-methyl ribonucleosides was greatly changed by the addition of wheat germ RNA. There was much more 2'-O-methylation of the purine ribonucleosides, relative to the pyrimidine ribonucleosides, in the reaction stimulated by wheat germ RNA. PMID- 4340156 TI - Viral-related RNA in Hodgkins' disease and other human lymphomas. AB - Molecular hybridization with radioactively labeled DNA complementary to the RNA of the Rauscher leukemia virus was used to probe for homologous RNA in human lymphomas. 22 of 32 specimens contained RNA possessing homology to the RNA of the mouse leukemia virus, but not to that of the unrelated viruses causing mammary tumors in mice or myeloblastosis in chickens. Normal adult and fetal tissues failed to show significant levels of the leukemia-specific RNA. It appears that human lymphomas contain RNA sequences homologous to those found in a viral agent known to cause leukemia and lymphomas in an experimental animal. The fact that human leukemias and sarcomas also contain this type of RNA further emphasizes a remarkable similarity between the corresponding neoplasias of murine and human origin. PMID- 4340157 TI - Selective inhibition of nuclear DNA synthesis by 9- -D-arabinofuranosyl adenine in rat cells transformed by Rous sarcoma virus. AB - The drug, 9-beta-D-arabinofuranosyl adenine, selectively inhibits the synthesis of nuclear DNA without affecting extrachromosomal DNA synthesis in rat cells transformed by Rous sarcoma virus (B-mix K-44/6). The inhibition was linear with respect to drug concentration over the range of 37-600 muM. Mitosis and total synthesis of DNA per cell were also depressed. DNA synthesis was determined by measurement of [(3)H]thymidine incorporation into DNA. Covalently-closed circular DNA was extracted by the Hirt procedure and separated from residual chromosomal DNA by buoyant density gradient ultracentrifugation in CsCl-propidium diiodide. On the basis of buoyant density and sedimentation velocity centrifugation, the covalently-closed circular DNA formed in the presence of the drug was indistinguishable from that formed in its absence. PMID- 4340158 TI - Identification of lactate dehydrogenase isoenzymes by rapid kinetics. AB - Stopped-flow kinetics indicate that human and chicken heart-type(4) lactate dehydrogenases (LDH) become inhibited as DPNH is oxidized in the presence of high concentrations of pyruvate. This inhibition is much less marked with the human and chicken muscle-type(4) enzymes. The initial rates and the difference in inhibition between the two types of enzyme have made it possible to determine the amount of, as well as the ratio between, the two types of LDH that are present in a given sample by a single kinetic assay. The stopped-flow kinetic method has been used to analyze amounts of LDH isoenzyme in different tissues, as well as in serum. PMID- 4340159 TI - 3':5'-cyclic adenosine monophosphate phosphodiesterase: negative cooperativity. AB - Kinetic and chromatographic analysis of cyclic nucleotide phosphodiesterase (EC 3.1.4.c) obtained from rat tissue has revealed that this enzyme exists in at least two molecular forms. After chromatographic separation, one form (cyclic AMP phosphodiesterase) still exhibits kinetics suggestive of the action of either two enzymes or one enzyme under negative cooperative regulation. Computer model studies were undertaken to distinguish between these two possibilities. The matrix method was used to generate the partition functions for (a) the sum of two independent enzymes and (b) one enzyme exhibiting negative cooperative kinetics. The experimental data were fitted to the theoretical models by a nonlinear least squares computer program. The results show that, while both models can fit the data, the two-enzyme model would require contamination far in excess of what is detectable physically or by activity measurements. Thus, the negative cooperative model seems the more appropriate theoretical explanation of the observed kinetic behavior of this enzyme. The implication of negative cooperativity with respect to the regulation of cyclic AMP concentrations in physiological systems is discussed. PMID- 4340160 TI - Heart attacks: possible risk factor. AB - Evidence is assembled from the literature to support the argument that myocardial infarction and death results from narrowing of coronary arteries-a process that may result from various causes, as discussed in this paper. Angiotensin and hypertension are suggested as among the chief components of such processes. PMID- 4340161 TI - Surface glycoproteins of normal and transformed cells: a difference determined by sialic acid and a growth-dependent sialyl transferase. AB - The pattern of elution from a column of Sephadex G-50 of a fucose-labeled carbohydrate component derived from the surface glycoproteins of transformed cells can be altered to resemble that from untransformed cells by enzymatic removal of the sialic acid. These results indicate that the consistent differences found between control and virus-transformed cells may depend upon a relatively specific sialyl transferase that is found in greater amounts (2.5- to 11-times) in transformed cells than in control cells, and in dividing cells as compared to nondividing cells. PMID- 4340162 TI - Polyadenylic acid at the 3'-terminus of poliovirus RNA. AB - Poliovirus RNA that has been derivatized at the 3'-end with NaIO(4)-NaB(3)H(4) yields, after hydrolysis with alkali or RNase T2, predominantly labeled residues of modified adenosine; no labeled nucleoside derivative is produced by digestion with RNase A or RNase T1. The 3'-terminal bases of the RNA are, therefore,...ApA(OH). Hydrolyzates of poliovirus [(32)P]RNA, after exhaustive digestion with RNase T1 or RNase A, contain, besides internal oligonucleotides, polynucleotides resistant to further action of ribonucleases T1 and A, respectively; these polynucleotides were isolated by membrane-filter binding or ion-exchange chromatography. The sequence of the T1-resistant polynucleotide was determined to be (Ap)(n)A(OH), that of the RNase A-resistant polynucleotide was GpGp(Ap)(n)A(OH). The chain length (n) of the polyadenylic acid, as analyzed by different methods, averages 89 nucleotides. Gel electrophoresis revealed heterogeneity of the size of poly(A). Poliovirus RNA, when labeled in vitro at the 3'-end, contains [3'-(3)H]poly(A); when labeled in vivo with [(3)H]A, it contains [(3)H](Ap)(n)A(OH). The data establish that... YpGpGp(Ap)([unk])A(OH) is the 3'-terminal sequence of poliovirus RNA, Type 1 (Mahoney). Since this mammalian virus reproduces in the cell cytoplasm, these observations may modify prior interpretations of the function of polyadenylate ends on messenger RNAs. PMID- 4340163 TI - Activating and protective capacities of a purified electrophoretic fraction of murine leukemia virus for murine leukemia virus infectivity. AB - A highly purified gel electrophoretic fraction of murine leukemia virus (MuLV) can confer enhanced infectivity on MuLV derived from tissue culture and can protect MuLV from neutralization by specific antiserum. Of the known viral proteins tested, a purified electrophoretic fraction (14,000 daltons) is the only active fraction and seems to consist of the group-specific antigen I and an associated lipid moiety. The action of this fraction obtained from one type of MuLV is group-specific in that it can enhance and protect serologically different types of MuLV. The effect of this fraction is exerted on viruses and not on cells. MuLV derived from tumors was not enhanced by the fraction, but became amenable to its action after a single passage through tissue culture. Reconstruction experiments suggested that the fraction may consist of an exterior protein associated with some lipids. This complex, which apparently protrudes on the viral surface, is required for infectivity and shields the type-specific antigen containing the hemagglutinating site. PMID- 4340164 TI - Patterns of Simian Virus 40 DNA transcription after acute infection of permissive and nonpermissive cells. AB - Small amounts of fractionated, denatured, (32)P-labeled DNA from SV40 virus were incubated with a large excess of the complementary RNA of SV40 prepared in vitro with Escherichia coli RNA polymerase; the viral DNA strands were separated on hydroxyapatite columns. The RNA present in green monkey cells late in the lytic cycle reacted with 40-42% of the strand complementary to the in vitro complementary RNA (minus strand), and 60-64% of the opposite (plus) strand. "Early lytic" RNA failed to significantly interact with the plus strand, but formed stable duplex molecules with 35-39% of the minus strand. The RNA prepared from mouse embryo cells 24 hr after infection with SV40 combined with 35-38% of the minus strand and 60-62% of the plus strand. In all cases, the same regions of either the plus or minus strand appear to be transcribed in permissive and nonpermissive infections. PMID- 4340167 TI - Effect of environmental pH on the efficiency of cellular hybridization. AB - The hybridization of a human and mouse cell was strikingly pH-dependent, with a well defined optimum at (about) pH 7.6-8.0. The yield of hybrid cell colonies (1 per 500-2000 heterokaryocytes) was several hundred times greater than that obtained at pH 6.8-7.2. Although there was a significant effect on the efficiency of cell fusion, the critical time for the pH effect was in the first 4-8 days after fusion, presumably while viable hybrids were being formed from the multinucleated heterokaryocytes. PMID- 4340165 TI - Cell cycle changes and the ability of cells to undergo virus-induced fusion. AB - Synchronized cells of the mouse leukemic cell line, L5178Y, were examined for their ability to undergo virus-induced fusion. Fusion capacity (defined as the percentage of the original unicellular population that is induced by virus to participate in a fusion event) was measured in cells that were (i) arrested by colcemid, (ii) released from colcemid block, and (iii) released from thymidine block. The results show that fusion capacity is minimal during G1 phase (less than 10%), and rises to a maximum (69%) in arrested mitosis. Treatment of nonsynchronized cells with trypsin increased their fusion capacity to the level characteristic of cells arrested in mitosis. Colcemid-arrested cells produced twice as many hybrid clones as nonsynchronized cells after they were plated in selective medium. PMID- 4340166 TI - Membrane dynamics in the action of dibutyryl adenosine 3':5'-cyclic monophosphate and testosterone on mammalian cells. AB - The first manifestation of reverse transformation, in which a permanent epithelial-like cell is reversibly transformed into a fibroblast-like cell by dibutyryl adenosine cyclic 3':5'-monophosphate, is the disappearance of a set of violently extending and retracting knobbed structures on the cell membrane with consequent tranquilization of the membrane. The cell then elongates to assume a fibroblast-like morphology. Permanently fibroblast-like cells, which have smooth membranes, can be changed into knobbed epithelial-like cells by the addition of either colcemid or cytochalasin B, agents that disorganize one or the other component, respectively, of the microtubular-microfibrillar system. Permanently smoothmembraned, epithelial-like cells also become knobbed by such treatment. All of these knobbed epithelial-like cells can be converted into smooth-membraned fibroblast-like cells by dibutyryl cAMP alone or with the aid of supporting molecules like testosterone. It is proposed that these are general phenomena and that the knobbed epithelial-like forms and the more highly differentiated smooth membraned fibroblast-like cells represent extreme situations with respect to the degree of organization of the microtubular-microfibrillar system inside the cell. PMID- 4340169 TI - [Radiotherapy of brain tumors especially using pendulum irradiation with ultra hard x-rays]. PMID- 4340168 TI - Complex lipid requirements for detergent-solubilized phosphoacetylmuramyl pentapeptide translocase from Micrococcus luteus. AB - Phospho-MurNAc-pentapeptide translocase activity in the membrane of M. luteus was lost upon addition of the detergent, Triton X-100, but could be restored by addition of lipid fractions to the assay. By assay in the presence of lipid, the activity of the Triton-solubilized enzyme could be measured. The synthesis of C(55)-isoprenyl-P-P-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide required C(55)-isoprenyl-P, and was stimulated by a neutral lipid. The exchange reaction of UDP-MurNAc-pentapeptide with UMP required a polar lipid fraction, but the reaction was not affected by C(55)-isoprenyl-P or the neutral lipid. Thus, measurement of activity of the detergent-solubilized enzyme requires addition of three lipids, the lipid substrate (C(55)-isoprenyl-P), the neutral lipid, and a polar lipid. PMID- 4340171 TI - Correlation between strain virulence and evaluation of growth in monoxenic culture of Entamoeba histolytica. PMID- 4340170 TI - [Planning of cobalt 60 teletherapy in brain tumors]. PMID- 4340172 TI - Respiration in intra-erythrocytic Plasmodium berghei. PMID- 4340173 TI - [Enzymes of bone metabolism]. PMID- 4340174 TI - [Participation of the vestibular nuclei in the genesis of the paradoxical phase of sleep]. PMID- 4340176 TI - [Cardiovascular effects of angiotensin II implantates on the intact unanesthesized rat. A contribution to produce a medium-term experimental hypertension]. PMID- 4340175 TI - [Mitochondria from rabbit reticulocytes. 3. Cytochrome and phospholipid content]. PMID- 4340178 TI - [Electron microscopic studies of the crystalline inclusions in the myeloma cells and kidney of K-Bence Jones protein type myeloma]. PMID- 4340177 TI - [Studies on erythrocyte metabolism in various hemolytic anemias: with special reference to pyruvate kinase deficiency]. PMID- 4340180 TI - [Animal experiments on the development of primary and secondary antibody formation in early life. II. Formation of immunologic memory in young, as compared to, adult NMRI mice]. PMID- 4340179 TI - [Importance of transfrontal orbitotomy for operative treatment of space-occupying intraorbital lesions. Results of 61 cases]. PMID- 4340181 TI - Reaction of parathion and malathion with peroxytrifluoroacetic acid, a model system for the mixed function oxidases. PMID- 4340182 TI - Protein and carbohydrate composition of Lp(a)lipoprotein from human plasma. PMID- 4340183 TI - Synthesis of a linear gramicidin by a combination of biosynthetic and organic methods. PMID- 4340184 TI - The structural analysis and enzymic synthesis of a pentasaccharide alpha-limit dextrin formed from amylopectin by Bacillus subtilis alpha-amylase. PMID- 4340185 TI - Studies on dextrans and dextranases. X. Types and percentages of secondary linkages in the dextrans elaborated by Leuconostoc mesenteroides NRRL B-1299. PMID- 4340186 TI - The degradation of hyaluronic acid by ferrous ions. PMID- 4340187 TI - Arterial angiotensin II and venous immunoreactive material before and during angiotensin infusion in man. PMID- 4340188 TI - [Tumor diagnosis using radioactive drugs. Principles, possibilities and limitations]. PMID- 4340189 TI - [Herpes infection of the external genitalia]. PMID- 4340190 TI - Glucocorticoids and gastric secretion: the role of cyclic adenosine-3',5' monophosphate. PMID- 4340191 TI - A new syndrome associated with hepatocellular carcinoma. PMID- 4340192 TI - [Perioral dermatitis, vaccination reaction following smallpox vaccination, Paget's disease, metastasis of melanoma, varicella, scabies, verrucae vulgares]. PMID- 4340193 TI - [Comparison of several methods of treating pulmonary tuberculosis]. PMID- 4340194 TI - [Frequency and clinical features of prenatal retroperitoneal malignant tumours]. PMID- 4340195 TI - [First results in rickets prevention using 25-HCC in premature infants]. PMID- 4340196 TI - Activity and stability of microsomal mixed function oxidase and NAD glycohydrolase in isolated perfused rat liver. PMID- 4340197 TI - The influence of pyrazole on ethanol-induced changes in carbohydrate metabolism of the liver. PMID- 4340200 TI - Diazoxide and the secretion of insulin. PMID- 4340198 TI - [Inhibition of adenyl cyclase preparations from rat kidney by calcium ions and various diuretics]. PMID- 4340199 TI - Effects of glucocorticoids on adenyl cyclase and phosphodiesterase activity in fat cell homogenates and the accumulation of cyclic AMP in intact fat cells. PMID- 4340201 TI - [Use of interferon in the complex treatment of young children with cytomegalic inclusion disease]. PMID- 4340202 TI - Bacterial contamination of food. PMID- 4340203 TI - Physiological changes in metabolic disorders of bone and evaluation of agents used in their treatment. PMID- 4340204 TI - Treatment of osteoporosis with diphosphonates. PMID- 4340205 TI - [Myoglobulin and cytochrome oxidase in the masticatory muscles in case of opening the bite]. PMID- 4340206 TI - [Clinico-morphological parallels in different forms of vestibular disorders of peripheral origin]. PMID- 4340207 TI - [Alteration of the activity of monophosphoesterases in the auditory analyzer upon the effect of sound of diverse duration and a frequency of 4,000 cycles per second]. PMID- 4340208 TI - An ultrastructural study of the body wall muscles of the pentastomid Reighardia sternae Dies. 1864 parasitic on the herring gull Larus argentatus Pontopp. PMID- 4340209 TI - [Nature and origin of the vitelline reserves in the oocyte of Lithobius forficatus L. (Myriapoda Chilopoda)]. PMID- 4340210 TI - Morphologic observations on the summer cell of Stilling in the interrenal gland of the American bullfrog (Rana catesbeiana). PMID- 4340213 TI - [Angiofibroma of the cavum]. PMID- 4340211 TI - [Ultrastructure of vascular processes of ependymal and glial cells in the infundibulum of the rat]. PMID- 4340212 TI - Histochemistry and ultrastructure of the epidermis and the subepidermal gland cells of the freshwater snails Lymnaea stagnalis and biomphalaria pfeifferi. PMID- 4340214 TI - [Cerebrospinal rhinorrhea: topography, dignosis, etiology]. PMID- 4340215 TI - The nature of the positive inotropic response of the isolated frog heart to theophylline and to iminazole. AB - 1. The mechanism of the positive inotropic responses to theophylline and to iminazole has been examined in the frog heart.2. Both theophylline and iminazole caused positive inotropic effects which declined to control amplitude with time despite continued exposure to the drugs. The duration of the response to iminazole was always longer than that to theophylline.3. On washout of theophylline and iminazole the amplitude of heart beat slowly decreased to a value below that in the control period.4. The theophylline response was not prevented by phentolamine or by propranolol given separately or in combination.5. Theophylline potentiated the staircase and prolonged the post-stimulation potentiation phenomena when its own inotropic activity had subsided but iminazole reduced the staircase effect at this time.6. Theophylline, iminazole and 3 x [Ca(2+)](o) all increased the influx of (45)Ca into isolated ventricles. Theophylline increased but iminazole and 3 x [Ca(2+)](o) slightly reduced (45)Ca efflux.7. Total cell calcium changes were only detected in ventricles exposed for 15 min to 3 x [Ca(2+)](o) or theophylline (5 x 10(-3)M). After 60 min exposure to theophylline the total cell calcium was not significantly different from controls.8. It is concluded that the positive inotropic responses to theophylline and iminazole can be interpreted in terms of the increased calcium influx which they produce and that interpretation of effects in terms of their action on phosphodiesterase should be treated with reservation. PMID- 4340216 TI - Human monkeypox. AB - Between October 1970 and May 1971, six cases of human infection with monkeypox virus were identified in Liberia, Nigeria, and Sierra Leone. Four of the cases were confirmed by virus isolation and two were diagnosed on the basis of epidemiological and serological investigations. All the cases occurred in unvaccinated individuals.Post-infection serological studies showed high haemagglutination-inhibition and neutralizing titres to pox group virus in four of the cases. Repeated challenge vaccination of all cases with potent smallpox vaccine resulted in equivocal reactions.In all, 24 susceptible household contacts were exposed to the infected cases, but none developed disease. All the contacts subsequently responded to vaccination with a primary reaction, thus confirming their susceptibility and ruling out asymptomatic infection. PMID- 4340217 TI - "White" poxvirus strains from monkeys. PMID- 4340218 TI - A human infection caused by monkeypox virus in Basankusu Territory, Democratic Republic of the Congo. AB - This paper presents clinical and epidemiological information on a patient with smallpox-like disease, from whom a monkeypox-like virus was isolated. The patient was the first recognized human monkeypox case in medical history. PMID- 4340220 TI - Poxviruses isolated from clinically ill and asymptomatically infected monkeys and a chimpanzee. AB - Poxviruses were isolated from the kidneys of an outwardly healthy chimpanzee trapped in an area of the Democratic Republic of the Congo where a case of monkeypox had recently occurred in man, from the kidneys of clinically healthy cynomolgus monkeys in a colony in the Netherlands, and from monkeys suffering from monkeypox during outbreaks in colonies in the USA. It was established that two of the three viruses isolated from animals asymptomatically infected-namely, strain Chimp-9 from the chimpanzee and strain 64-7255 from the cynomolgus monkeys although similar to one another differed markedly from the classical Copenhagen strain of monkeypox virus. These two viruses were characterized by the formation of small, monomorphic, well-defined pocks without haemorrhages on infected chick embryo chorioallantoic membrane, by the small plaques of the proliferative type that they produced in cell cultures, by the absence of reactions when they were applied to scarified rabbit skin and the absence of marked necrosis when they were inoculated intradermally into rabbits, by their intensive replication in pig embryo kidney cell cultures, and by a number of other features. It is therefore possible to describe both the viruses as being very close to the variola virus. The Chimp-9 and 64-7255 strains differed from the variola virus only in their greater pathogenicity for white mice after intracerebral inoculation. The other virus isolated from a symptomless cynomolgus monkey-strain 64-9411-resembled the two viruses isolated from monkeys suffering from monkeypox and did not differ from the Copenhagen strain. PMID- 4340219 TI - Isolation and properties of the causal agent of a new variola-like disease (monkeypox) in man. AB - The causal agent of a case of disease in man occurring in the Democratic Republic of the Congo with a similar clinical picture to smallpox was isolated and studied. The agent was identified as monkeypox virus. A comparative study of the isolated strain (Congo-8) and of viruses isolated from similar cases of illness in Liberia (Liberia-1 and Liberia-2 strains) and Sierra Leone (V-70 1 266 strain) showed that they were identical. A number of local species of monkeys and apes were examined serologically in the Congo region to determine the probability of human infection with monkeypox virus. It was confirmed that the animals had had contact with an agent of the poxvirus group. In 2 of the 7 sera examined, antibodies of the variola-vaccinia group of poxviruses were discovered (virus neutralizing antibodies, precipitins, and antihaemagglutinins). In a chimpanzee, antihaemagglutinins were found in a titre of 1: 1 280, and in the same animal a variola-like virus was isolated from the kidneys. In the course of the investigation, it was shown conclusively that monkeypox virus and the strains under investigation could be distinguished from o dinary variola and vaccinia viruses on the basis of their behaviour in pig embryo kidney continuous cell line culture. PMID- 4340221 TI - An unusual poxvirus from Nigeria. AB - A poxvirus of the variola-vaccinia subgroup was isolated from the lesions of a female African refugee suffering from a smallpox-like illness. The virus is interesting because it is neither variola nor vaccinia but combines some properties of each. These properties are described and the possible origin of the virus is discussed. PMID- 4340222 TI - Outbreaks of monkeypox and serological surveys in nonhuman primates. AB - In connexion with the recent detection of cases of monkeypox in man in West and Central Africa, the frequency of monkeypox outbreaks in monkeys since 1958, when the disease was first recognized in captive animals, has been investigated. Special incidence surveys were made for this purpose. During the last 3 years, a serological survey has been conducted to find natural foci of monkeypox virus, and a total of 2 242 sera from monkeys of different species from various parts of Africa and Asia have been examined for poxvirus antibodies. The survey failed to detect any significant indication of poxvirus infections. The observations suggest that although a few human cases of monkeypox have been identified, monkeypox in the natural environment is not widespread and is perhaps localized in small areas. PMID- 4340223 TI - Human infection with monkeypox virus: laboratory investigation of six cases in West Africa. AB - Between September 1970 and May 1971 six cases of human infection with monkeypox virus were identified in three West African countries-Liberia, Sierra Leone, and Nigeria. Four of the cases were confirmed by viral isolation, and two were diagnosed on epidemiological and serological evidence. Poxvirus strains isolated from the four cases were indistinguishable from reference monkeypox strains (Copenhagen and Utrecht), and all were easily differentiated from variola and vaccinia viruses. The isolated strains produced small necrotic haemorrhagic pocks on CAM, grew well at 39.0 degrees C, formed large plaques in Vero cell cultures, showed markedly more virulence for chick embryos and mice than do variola strains, and produced large necrotic haemorrhagic local lesions with generalized illness and florid secondary exanthem when inoculated into rabbit skin.The finding of smallpox-like illness in humans resulting from infection with a poxvirus of lower animal origin serves to emphasize the importance of thorough epidemiological and laboratory evaluation of all suspect smallpox cases occurring in areas where smallpox has been or is about to be eradicated. PMID- 4340224 TI - Metabolic actions of tyramine and McNeil-A-343 in euthyroid and hyperthyroid rats. PMID- 4340225 TI - Effects of AMP and cyclic AMP on the mechanical and electrical activity of isolated mammalian atria. PMID- 4340226 TI - Cyclic nucleotide phosphodiesterase inhibition and vascular smooth muscle relaxation. PMID- 4340227 TI - The adenylcyclase complex: a model of its mechanism of action in relation to the - and -adrenergic receptors. PMID- 4340228 TI - 2-Halogenoethylamines and the role of Ca 2+ in adrenergic -receptor activation in the rat vas deferens. PMID- 4340229 TI - The effects on frog neuromuscular transmission of agents which act upon microtubules and microfilaments. PMID- 4340230 TI - Factors affecting turnover rates in mental hospitals. PMID- 4340231 TI - Providing comprehensive mental health services with local resources. PMID- 4340233 TI - [Formation of lipid peroxide in rat liver mitochondria. I]. PMID- 4340232 TI - The effect of anaerobiosis and uncouplers on the stimulation of -galactosidase synthesis by cyclic 3',5'-adenosine monophosphate in Escherichia coli. PMID- 4340234 TI - [Neurology. Side effects and complications of drug therapy]. PMID- 4340236 TI - Nature and etiology of the Poland anomaly. PMID- 4340235 TI - Use of phosphate and vitamin D to prevent dwarfism and rickets in X-linked hypophosphatemia. PMID- 4340237 TI - Etiology of congenital defects. PMID- 4340239 TI - Congenital epulis. PMID- 4340238 TI - Vincristine neurotoxicity. PMID- 4340240 TI - Catch-up growth in malnutrition, studied in celiac disease after institution of gluten-free diet. PMID- 4340241 TI - [Radiotherapy of cylindromas in the head and neck region]. PMID- 4340242 TI - [Experimental studies on the mode of action of substances promoting radioresistance]. PMID- 4340243 TI - [Biochemical studies on rabbit reticulocytes following administration of ionizing rays]. PMID- 4340245 TI - Changes in the concentration of lipids at different stages of growth in the blood trypomastigotes of T. brucei. PMID- 4340244 TI - Estrogenic therapy in men with ischemic cerebrovascular disease: effect on recurrent cerebral infarction and survival. Final report of the Veterans Administration cooperative study of atherosclerosis, neurology section. PMID- 4340246 TI - [Vinca alkaloids, a newer group of anti-neoplastic drugs]. PMID- 4340247 TI - [The infectivity of cattle with adenoviruses]. PMID- 4340248 TI - [Blood coagulation and anticoagulation system in Botkin's disease depending on the severity of the disease]. PMID- 4340249 TI - Cholinergic and adrenergic neural structures of the ventricular epicardium. PMID- 4340250 TI - Septomammillary projections in the squirrel monkey. PMID- 4340251 TI - Further studies on the ultrastructure of the pars distalis of the male mouse hypophysis. PMID- 4340252 TI - Infectious mononucleosis: epidemiologic patterns at United States colleges and universities. PMID- 4340253 TI - [Streptozotocin]. PMID- 4340255 TI - [Induction of malignomas in rats after transplacental exposure to N-isopropyl alpha-2-(methyl-hydrazino)-p-toluamide-HCl]. PMID- 4340254 TI - [Effect of aminoadamantane sulfate on night sleep in Parkinson's disease]. PMID- 4340257 TI - Inhibition of oxalate synthesis: in vitro studies using analogues of oxalate and glycolate. PMID- 4340256 TI - Accelerated erythrocyte 5-phosphoribosyl-1-pyrophosphate synthesis. A familial abnormality associated with excessive uric acid production and gout. PMID- 4340258 TI - Interactions of spin-labeled lipid molecules with natural lipids in monolayers at the air-water interface. PMID- 4340259 TI - Differential isolation of microvillous and basolateral plasma membranes from intestinal mucosa: mutually exclusive distribution of digestive enzymes and ouabain-sensitive ATPase. PMID- 4340260 TI - Correlations between fluorescence, x-ray diffraction, and physiological properties in cytoplasmic membrane vesicles isolated from Escherichia coli. PMID- 4340261 TI - Membranes from Myxococcus fulvus (Myxobacterales) containing carotenoid glucosides. I. Isolation and composition. PMID- 4340262 TI - Activation by phospholipids of particulate mitochondrial ATPase from rat liver. PMID- 4340263 TI - The effect of phospholipids on the apparent activation energy of (Na+-K+)-ATPase. PMID- 4340264 TI - Membrane transport as controlling pacemaker of glycolysis in Saccharomyces carlsbergensis. PMID- 4340265 TI - Plasma membranes from isolated liver cells. PMID- 4340266 TI - Ubiquinone and related compounds. XX. Coenzymatic activity of ubiquinone and related compounds. II. PMID- 4340267 TI - The permeability of Rhodospirillum rubrum chromatophores to thiocyanate and perchlorate as detected by light-induced fluorochrome fluorescence changes and by photophosphorylation. PMID- 4340268 TI - Evidence for the occurrence in submitochondrial particles of a dual respiratory chain containing different forms of cytochrome b. PMID- 4340269 TI - Soluble cytochrome b 5 from human erythrocytes. PMID- 4340270 TI - [Separation of internal and external mitochondrial membranes from the yeast Saccharomyces cerevisiae]. PMID- 4340271 TI - [New possibility of rapid diagnosis by photonic immunoperoxidase microscopy human cell infection by the Herpex simplex hominis virus]. PMID- 4340272 TI - [Theophylline inhibition of the immunologic stimulation induced by phenylimidothiazole]. PMID- 4340273 TI - [Net intestinal absorption of 25-hydroxychlecalciferol in children]. PMID- 4340274 TI - [Demonstration of 3'5'-cyclic AMP phosphodiesterase activity in the human placenta at term]. PMID- 4340275 TI - Dedifferentiation of the disaggregated slug cell of the cellular slime mold Dictyostelium discoideum. PMID- 4340276 TI - N 6 -monobutyryladenosine 3':5'-mono phosphate as the biologically active derivative of dibutyryladenosine 3':5'-monophosphate in HeLa S3 cells. PMID- 4340277 TI - Enhancement of ubiquinone-9 biosynthesis in rat-liver slices by exogenous mevalonate. PMID- 4340278 TI - [Polymorphism of red cell NADH-diaphorase in Western German population]. PMID- 4340279 TI - Electrical properties and excitation-contraction coupling in skeletal muscle treated with ethylene glycol. AB - The contractility of the frog sartorius muscle was suppressed after treatment with a Ringer solution added with ethylene glycol (EGR). No contraction was elicited by nerve stimulation when the muscle was brought back to normal Ringer solution after having been soaked in 876 mM EGR for 4 hr or in 1095 mM EGR for 2 hr. However, the action potential of normal amplitude was generated and followed by a depolarizing afterpotential. The resting membrane potential was slightly decreased from the mean normal value of -91.1 mv to -78.8 mv when 1095 mM EGR was used, and to -82.3 mv when 876 mM EGR was used, but remained almost constant for as long as 2 hr. The afterpotential that follows a train of impulses and a slow change in membrane potential produced by a step hyperpolarizing current (so called "creep") were suppressed after treatment with ethylene glycol. The specific membrane capacity decreased to about 50% of the control values while the specific membrane resistance increased to about twice the control values Therefore, the membrane time constant remained essentially unchanged. The water content of the muscle decreased by about 30% during a 2 hr immersion in 1095 mM EGR, and increased by about 30% beyond the original control level after bringing the muscle back to normal Ringer. The intracellular potassium content did not change significantly during these procedures. Some differences between the present results and those obtained with glycerol are discussed. PMID- 4340280 TI - Comparison of structural polypeptides from vesicular stomatitis virus (Indiana and New Jersey serotypes) and Cocal virus. PMID- 4340281 TI - Inhibition of virus-induced cell fusion by local anaesthetics and phenothiazine tranquilizers. PMID- 4340282 TI - Studies on the mechanism of cytoplasmic antigen accumulation following infection with a new variant of polyoma virus. PMID- 4340283 TI - Microelectrophoresis of enzyme and chemically treated viruses and cores of vaccinia, buffalopox, variola and alastrim. PMID- 4340284 TI - Virus infection as a function of the host cell life cycle: replication of poliovirus RNA. PMID- 4340285 TI - Receptors for immunoglobulin and complement on mouse leukemias and lymphomas. PMID- 4340286 TI - A model system for study of subcellular distribution of cell surface antigens. PMID- 4340287 TI - [A study on adrenocortical function test in pregnant women]. PMID- 4340288 TI - Critical bleeding and plasma volumes of the adult germfree rat. PMID- 4340289 TI - Parasites of marmosets. PMID- 4340290 TI - The relative efficiencies of ball-bearing-equipped drinking tubes and valveless drinking tubes. PMID- 4340291 TI - Corynebacterium ulcerans infections in monkeys. PMID- 4340293 TI - Natural Herpesvirus hominis infection of tree shrews (Tupaia glis). PMID- 4340292 TI - Induction of local electroanesthesia in dogs. PMID- 4340294 TI - Histopathologic study of the heads of circling mice infected with Pseudomonas aeruginosa. PMID- 4340297 TI - A simple, inexpensive diaphragma-type skin connector for implanted catheters. PMID- 4340295 TI - A purified soy protein diet for nutrition studies with germfree rats. PMID- 4340298 TI - A method for repeated sampling of testis tissue from small mammals. PMID- 4340296 TI - A comparison of hemoglobins of several laboratory animals. PMID- 4340299 TI - Hematology of the black-tailed jack rabbit, (Lepus californicus californicus). PMID- 4340300 TI - Two cases of torsion of the cecum and ileum in rats. PMID- 4340301 TI - Simultaneous intravenous infusion and arterial blood sampling in piglets. PMID- 4340303 TI - Sciatic cross-innervation of parabiotic mice. I. Surgical method and comments on animal care. PMID- 4340302 TI - A simple technic for the sexing of newborn rabbits. PMID- 4340304 TI - An automatic and self-adjusting photoperiod device for duplicating the external daylength. PMID- 4340305 TI - Growth of maturing Macaca mulatta. PMID- 4340306 TI - Premedication, tracheal intubation, and methoxyflurane anesthesia in the rabbit. PMID- 4340307 TI - A case of guinea pig conjoined twins. PMID- 4340308 TI - Weights and measurements of normal squirrel monkeys (Saimiri sciureus). PMID- 4340310 TI - Maternal deprivation in mice and rats. PMID- 4340309 TI - Generalized amyloidosis in a rhesus monkey. PMID- 4340311 TI - Parasites of the house mouse in Iran. PMID- 4340314 TI - Experience in laboratory diagnosis of enterovirus infections in routine medical practice. PMID- 4340313 TI - [Value of plasma renin activity determination in clinical practice]. PMID- 4340312 TI - [Hereditary skin diseases related to sex]. PMID- 4340315 TI - [Effects of heat-labile toxin of B. pertussis on mouse blood cells: the determination of LPF (leukocytosis-promoting factor)]. PMID- 4340317 TI - Case for diagnosis. PMID- 4340316 TI - Liver resection. PMID- 4340319 TI - [Cyclic adenosine phosphate in the caused chain of hormone activities]. PMID- 4340318 TI - [Regulation of tumor growth by adenosine-3',5'-monophosphate]. PMID- 4340320 TI - [Study of nocturnal sleep in epileptic children and adults]. PMID- 4340321 TI - [Myoclonic epilepsy with inclusion bodies (Lafora's disease)--(clinico-pathologic case report)]. PMID- 4340322 TI - [Our experiences with ACTH therapy in epilepsy]. PMID- 4340323 TI - Effect of cycloheximide on the rat adrenal cortex: a light and electron microscopic study. PMID- 4340324 TI - Influence of maturity on the vesicular population of the adrenergic nerve endings of guinea-pig seminal vesicles. PMID- 4340325 TI - Role of the cell factor in SV40 transformation. PMID- 4340327 TI - The non symbiotic origin of mitochondria. PMID- 4340326 TI - The effect of toluidine blue on ribonucleic acid synthesis in normal and poliovirus infected KB cells. PMID- 4340328 TI - [Lyophilised vein as a vascular prosthesis]. PMID- 4340329 TI - [Physiopathologic bases of diagnosis and treatment of primary hyperaldosteronism]. PMID- 4340330 TI - Gestational choriocarcinoma in Denmark 1940-1969. A reappraisal based on modern histologic criteria. PMID- 4340331 TI - Endodermal sinus tumour. PMID- 4340332 TI - Analysis of facial reflex facilitation and inhibition by microelectrode recording from the brain stem. PMID- 4340334 TI - Cell proliferation in rat kidneys after prolonged treatment with lead. AB - Effects of chronic lead intoxication on cellular proliferation in rat kidneys were investigated by autoradiography. The rats were given intraperitoneal injections of lead acetate in aqueous solution for 6 months. At the end of this period, the proliferative activity of proximal tubular epithelial cells was about 15 times greater in rats given lead than in untreated controls. In the leaded rats approximately 40% of the proximal tubular cells contained intranuclear inclusions, approximately 0.5% of proximal tubular epithelial cells were labeled and approximately 6% of labeled cells contained intranuclear inclusions. Thus, cells with intranuclear inclusions can replicate DNA. Effects of chronic lead poisoning on the replication of proximal tubular cells in rats subjected to left uninephretomy before inception of treatment with lead were substantially the same. No renal carcinomas were found after 6 months of treatment with lead, but there was epithelial hyperplasia in some proximal tubules, with occasional atypia. The presence of increased synthesis of DNA and epithelial hyperplasia in the kidneys of rats chronically poisoned with lead suggests that the renal carcinogenicity of lead, observed by others, is related to lead-induced stimulation of renal cell proliferation. PMID- 4340333 TI - Lysosome and phagosome stability in lethal cell injury. Morphologic tracer studies in cell injury due to inhibition of energy metabolism, immune cytolysis and photosensitization. AB - In two types of cell injury in a tissue culture system, the possibility was tested that lysosome rupture may be a lethal cellular reaction to injury, and thus an important general cause of irreversibility of damage in injured tissue. Prior labeling of secondary lysosomes with the fluorochrome acridine orange, or with ferritin, was used to trace changes in lysosomes after applying an injury. The metabolic inhibitors iodoacetate and cyanide were used together to block the cell's energy supply, or attachment of antiserum and subsequent complement attack were used to damage the surface membrane, producing rapid loss of cell volume control. Living cells were studied by time-lapse phase-contrast cinemicrography and fluorescence microscopy, and samples were fixed at intervals for electron microscopy. The cytolytic action of complement was lethal to sensitized cells within 2 hours, but results showed that lysosomes did not rupture for approximately 4 hours and in fact did not release the fluorescent dye until after reaching the postmortem necrotic phase of injury. Cells treated with metabolic inhibitors also showed irreversible alterations, while lysosomes remained intact and retained the ferritin marker. The fluorochrome marker, acridine orange, escaped from lysosomes early after metabolic injury, but the significance of this observation is not clear. The results are interpreted as evidence against the concept that lysosome rupture threatens the survival of injured cells. The original suicide bag mechanism of cell damage thus is apparently not operative in the systems studied. Lysosomes appear to be relatively stable organelles which, following injury of the types studied, burst only after cell death, acting then as scavengers which help to clear cellular debris. PMID- 4340335 TI - The variable prevalence of junctional-complex-associated bodies in the human sweat gland. AB - Sweat gland biopsies have been examined for their content of junctional-complex associated (JCA) bodies. These bodies have been observed at the lumen of the gland as well as the intercellular canaliculi. A JCA body was encountered in each of two dark cells with uncondensed secretory granules; one of these cells was from a specimen in which no other bodies could be found after an extensive search. All other JCA bodies occurred in either clear or undifferentiated cells. Junctional-complex-associated bodies occupied pairs of adjacent cells rather frequently, but no cell revealed more than one body. The prevalence of JCA bodies varied widely among specimens. Glands lacking morphologic abnormalities, and others with some atypical features, disclosed few or no such bodies. Some glands that contained JCA bodies also contained coil cells with extensive vacuolization, which occurred as a manifestation of Hurler's disease or on an unexplained basis. Glands from a patient with cystic fibrosis exhibited the highest prevalence of JCA bodies. Some of the coil profiles in glands near a scar in one specimen were composed of undifferentiated cells with rare mitotic figures and no identifiable clear or dark cells. Numerous JCA bodies, particularly at the lumen, were found in sweat glands in this and another specimen containing frequent undifferentiated cells. PMID- 4340337 TI - [Major hepatic resection]. PMID- 4340336 TI - Transmission of Marek's disease by shedder chickens: extraction of virus and soluble antigen from skin. PMID- 4340338 TI - [Immunofluorescent examination for adenovirus infection]. PMID- 4340339 TI - Experimental malignant tumors from retinal pigment epithelium. PMID- 4340340 TI - [Effect of xantinol-nicotinate on brain metabolism. Experimental animal study of the effect on glucose-C 14 permeation and pyridine and adenone nucleotides]. PMID- 4340341 TI - Action on fibrinolysis and platelet aggregation of a synthetic, heparin-like sulfated polyanion (SP 54) given orally and parenterally, as related to lipidic fractions. Trials on long-term prophylactic treatment under double-blind conditions. PMID- 4340342 TI - Fractions of Chinese hamster DNA differing in their content of guanine+cytosine and evidence for the presence of single-stranded DNA. PMID- 4340344 TI - The pattern of enteroviral infections in a herd of swine. AB - Twenty-six pigs from four litters in a healthy herd of swine were examined periodically for the fecal excretion of viruses by the use of porcine kidney cell cultures. Viruses were initially isolated from all pigs between 34 to 64 days of age. The pigs within each litter began shedding virus in their feces approximately at the same time, usually within one week, and the type of virus initially recovered was usually the same. Subsequently, waves of infection with different enteroviruses appeared to occur during the observation period of six months. At least six antigenically different viruses were isolated from this herd over a 26-month period. Most, if not all, of these viruses were considered to belong to the enterovirus group. No disease was associated with these enteroviral infections. The colostrum and milk of sows contained significant amounts of enteroviral antibodies. Prior to nursing, the serum of new-born pig contained no enteroviral antibodies but, shortly after nursing, high titers of such antibodies were present in the serum. Antibodies were detected in the feces of suckling pigs. PMID- 4340343 TI - Nuclear polyadenosine diphosphoribosylation during restricted macromolecular synthesis of HeLa cells. PMID- 4340345 TI - Swine interferon. I. Induction in porcine cell cultures with viral and synthetic inducers. AB - The production of interferon by porcine kidney (PK(15)) cell culture in response to viral and synthetic inducers was studied. The inducers used included a synthetic double-stranded polyribonucleotide, polyriboinosinic-polyribocytidylic acid (Poly I:C), swine influenza virus and three strains of pseudorabies virus. Following exposure to these inducers cell culture fluids were examined for interferon by the plaque-reduction method. The Poly I:C and the swine influenza virus induced production of interferon by PK(15) cell cultures, whereas, all three strains of pseudorabies virus at the two concentrations tested failed to induce production of interferon in vitro. The antiviral substance produced in PK(15) cells was identified as an interferon because it was pH stable, non dialyzable, sensitive to trypsin, non-sedimentable, relatively heat stable, host species specific and it possessed broad-spectrum antiviral activity. The latter was demonstrated by inhibition of vesicular stomatitis, vaccinia and pseudorabies viruses. Differences in interferon activity against the different viruses were observed. PMID- 4340348 TI - Endogenous regulation of the pulmonary response to isoproterenol. PMID- 4340346 TI - Swine interferon. II. Induction in pigs with viral and synthetic inducers. AB - The production of interferon by pigs in response to viral and synthetic inducers was studied. The inducers used included polyriboinosinic-polyribocytidylic acid (Poly I:C), swine influenza virus and pseudorabies virus. Following intravenous inoculation of pigs with the inducers, sera were examined for interferon by the plaque-reduction method in porcine kidney (PK(15)) cell cultures using vesicular stomatitis virus as the challenge inoculum. It was shown that pigs can produce interferon in response to each of these inducers. The pseudorabies virus used in this investigation was found to be a better interferon inducer than the swine influenza virus. The interferon produced in pigs was identified as an interferon because it was pH stable, non-dialyzable, sensitive to trypsin, non-sedimentable and possessed broad-spectrum antiviral activity as well as host-species specificity. PMID- 4340347 TI - Physical, chemical and biological characteristics of two bovine enterovirus plaque variants. AB - Large plaque (4LP) and small plaque (4SP) variants were derived from a parent bovine virus strain by serial plaque passage. Both 4LP and 4SP were resistant to chloroform and stabilized at 50 degrees C for one hour by 1.0 M magnesium chloride. Both 4LP and 4SP had buoyant densities in cesium chloride of 1.36 gm/ml. Antigenically, 4LP and 4SP were reciprocally cross neutralizable. The nucleic acid of 4LP was shown to be ribonucleic acid (RNA) by resistance of its infectivity to deoxynuclease (DNase) but not ribonuclease (RNase) and by increased incorporation of [(3)H]-uridine into cytoplasmic RNA in cells of virus infected cultures. In growth characteristics, both 4LP and 4SP had maximum adsorption times of 75 to 90 minutes but 4LP had more rapid replication and release rates and yielded nearly twice as many infectious units per cell as 4SP. The differences in growth properties correlated directly with the differential in plaque diameter which was 40-50%. PMID- 4340349 TI - Solitary primary chemodectomas of the lung. PMID- 4340350 TI - Distinctive ultrastructural findings in a case of idiopathic interstitial pneumonia. PMID- 4340351 TI - [Thyrocalcitonin in the picture of calcium homeostasis: physiopathological aspects and prospects of its therapeutic use]. PMID- 4340352 TI - The effect of cyclic AMP on morphogernesis and enzyme accumulation in Dictyostelium discoideum. PMID- 4340353 TI - [Determination of adenine, adenosine, adenosine-5'-monophosphoric acid, thymine and thymidine by gel filtration]. PMID- 4340354 TI - [Functioning tumors: insulinomas of the pancreas]. PMID- 4340355 TI - Analysis of the tissue constituents and enzymes of human liver by crossed immunoelectrophoresis--comparison of normal and cystic fibrosis liver. PMID- 4340356 TI - The effect of various adjuvant regimens and of nematode infection on the reaginic antibody response to egg-albumin in the rat. PMID- 4340357 TI - Spore formation and germination of Clostridium perfringens in the digestive tract of holoxenic and axenic mice. PMID- 4340358 TI - On the locus of action of Na + at site I of oxidative phosphorylation. PMID- 4340359 TI - Microwave charge carrier Hall mobility measurements on cytochrome-oxidase prepared from heavy beef heart mitochondria. PMID- 4340363 TI - The hospital care of East African children. Neonates--care and after care. PMID- 4340364 TI - Further studies on the lipolytic effect of excess potassium on rat brown adipose tissue. PMID- 4340365 TI - [Hemagglutination inhibiting substances in Japanese encephalitis infected frogs during and after hibernation]. PMID- 4340366 TI - [Testing of angiotensinamide]. PMID- 4340360 TI - Mitochondrial oxidative phosphorylation at site I involving a fatty aldehyde-acid couple. PMID- 4340367 TI - [Influence of auxillary substances on the release of hard-to-solve drugs from a hydrophobic tablet matrix]. PMID- 4340368 TI - [In vitro liberation from suspension ointments]. PMID- 4340369 TI - Rapid eye movements and visual imagery during sleep. PMID- 4340370 TI - Studies on the interaction of warfarin and clofibrate in man. PMID- 4340371 TI - Surgery of jaw tumours. PMID- 4340372 TI - From protozoa to bacteria and viruses. Fifty years with microbes (Andre Lwoff). PMID- 4340374 TI - Aggregation and differentiation in the cellular slime molds. PMID- 4340373 TI - The role of viruses as causes of congenital diseases. PMID- 4340375 TI - [Ovarian mulleroblastoma. Apropos of a case]. PMID- 4340376 TI - [Ultrastructural study of a case of amyloid neuropathy]. PMID- 4340377 TI - Late onset ataxia, rigidity, and peripheral neuropathy. A familial syndrome with variable therapeutic response to levodopa. PMID- 4340378 TI - Neuropsychiatric manifestations of typhoid fever in 959 patients. PMID- 4340379 TI - The Eaton-Lambert syndrome. Report of a case. PMID- 4340380 TI - [Histoenzymological study of the "salt" gland of the Sahara lizard, Uromastix acanthinurus Bell]. PMID- 4340381 TI - [Effects of vesicular stomatitis virus on ribonucleic acid metabolism in chick embryo cells: study in the presence of cycloheximide]. PMID- 4340382 TI - [Ultrastructure of medullary granulocytes in patas monkeys: periodic structures in neurophilic and basophilic granules]. PMID- 4340383 TI - [Effects of intraventricular injection of 6-hydroxydopamine on sleep states and cerebral monoamines in cats]. PMID- 4340384 TI - [Sequential analysis of eye movements during paradoxical sleep in humans]. PMID- 4340385 TI - [Effects of chronic heat exposure on the wakefulness-sleep cycle in the albino rat: 30 degrees C ambient temperature]. PMID- 4340387 TI - Structure of a (1 leads to 3)- -D-glucan (pseudonigeran) of Aspergillus niger NNRL 326 cell wall. PMID- 4340386 TI - Spontaneous AK leukemia (lymphoma) as a model for human leukemias and lymphomas. PMID- 4340388 TI - The isolation of 3-deoxy-D-erythro-hexos-2-ulose from beef livers. PMID- 4340390 TI - Reaction of the main proteolytic fraction of Schistosoma mansoni cercarial enzymes with synthetic substrates and inhibitors of proteolytic enzymes. PMID- 4340389 TI - Acute and chronic cardiovascular effects of 6-hydroxydopamine in dogs. PMID- 4340391 TI - [Intracranial calcifications in childhood]. PMID- 4340392 TI - [The radiological demonstration of intra-cranial masses with intra-ventricular iothalamate (Conray)]. PMID- 4340393 TI - [Peripheral, calvarial activity increase in the 99mc Tc-pertechnate brain scintigram]. PMID- 4340394 TI - [Comparative color scintigraphic studies using technetium 99m-pertechnate and indium 113m-EDTA in brain diseases]. PMID- 4340396 TI - [The growth of arterio-venous angiomas of cerebral vessels]. PMID- 4340395 TI - [Myelo-scintigraphy in the pre-operative evaluation of space-occupying lesions in the spinal canal]. PMID- 4340398 TI - [The scope of direct breast lymphography]. PMID- 4340397 TI - [A rare combined dysplasia in Recklinghausen's neurofibromatosis]. PMID- 4340399 TI - [A suggestion for the determination of lymph node volume from a lymphogram. 4. Determination of precision in a model study]. PMID- 4340400 TI - ["Primary essential phlebosclerosis". "Peri-venous calcinosis". "Sleeve-like venous obstructive ossification". An attempt at a new classification of phlebosclerosis]. PMID- 4340401 TI - [Measurements of flow velocity in the veins of the lower extremities using radio nucleides]. PMID- 4340402 TI - [Pharmacokinetics of a hepatotropic and a renotropic x-ray contrast medium during hemodialysis]. PMID- 4340403 TI - [Gonadal exposure during three standard radiological examinations (gastro intestinal tract, chest, urogram)]. PMID- 4340404 TI - [Roentgen spectrometric and roentgen dosimetric measurements of beam quality for soft tissue radiography]. PMID- 4340405 TI - [Traumatic prolapse of the liver into the chest]. PMID- 4340406 TI - [Cystic lymphangiomatosis of the spleen]. PMID- 4340407 TI - [Congenital intestinal atresia--hydramnion--"wet-lung disease"]. PMID- 4340409 TI - [Tomographic demonstration of unusual injury sequelae on the axis]. PMID- 4340408 TI - [Calcified brain abscess]. PMID- 4340410 TI - [Calcinosis of the posterior longitudinal ligament combined with vertebral body excavations]. PMID- 4340411 TI - [Clavicular lesions located on the caudal third of the sternum]. PMID- 4340412 TI - [Congenital aplasia of the symphysis]. PMID- 4340413 TI - [Rare ossification of a ligament in the area of the left foramen obturatum]. PMID- 4340414 TI - [Resection of the mandible in oral tumours]. PMID- 4340415 TI - Some considerations of the multiplicity of insulin action on adipose tissue. PMID- 4340416 TI - Insulin effector system of fat cells: its destruction with trypsin and subsequent restoration. PMID- 4340417 TI - Effects of insulin and substances having insulin-like activity on adipose cells: sugar utilization, lipolysis, adenyl cyclase-cyclic AMP system and cyclic AMP dependent protein kinase. PMID- 4340418 TI - Comparative study of hormonal regulation of adenyl cyclase activity in rat and rabbit fat cell membranes. PMID- 4340419 TI - Effect of insulin on the transport and metabolism of amino acids in isolated fat cells. PMID- 4340420 TI - Structural and chemical compartments in adipose cells. PMID- 4340421 TI - Hormonal control of human adipose tissue metabolism in vitro. PMID- 4340422 TI - Studies on the major pathways of hepatic lipid metabolism using the perfused liver. PMID- 4340423 TI - The fat cell in mid-term: its past and future. PMID- 4340425 TI - Pituitary-adrenal control of fat mobilization in rabbits. PMID- 4340424 TI - The involvement of RNA synthesis and cyclic AMP in the activation of fat cell lipolysis by growth hormone and glucocorticoids. PMID- 4340426 TI - Lipase activities in adipose tissue. PMID- 4340428 TI - Cations and lipolytic activity in rat adipose tissue. PMID- 4340427 TI - Electrolytes and the hormonal control of organic metabolism in adipocytes. PMID- 4340429 TI - The influence of lipolysis on energy metabolism of isolated fat cells. PMID- 4340430 TI - Dependence of hormone-stimulated lipolysis on ATP and cyclic AMP levels in fat cells. PMID- 4340431 TI - Mitochondrial energy production and hormone-stimulated lipolysis. PMID- 4340432 TI - Adrenocorticotropin alteration of bovine peripheral plasma concentrations of cortisol, corticosterone, and progesterone. PMID- 4340433 TI - Anterior interosseous nerve syndrome. A case report with neurophysiological investigation. AB - Details of a 23 year old patient who suffered the spontaneous onset of an anterior interosseous nerve palsy are recorded together with the results of a full neurophysiological investigation. PMID- 4340434 TI - Impairment of repetitive impulse conduction in experimentally demyelinated and pressure-injured nerves. AB - Repetitive impulse conduction was studied in segmentally demyelinated peripheral nerves in guinea-pigs with experimental allergic neuritis (EAN) and in pressure injured frog sciatic nerves. Normal guinea-pig sciatic-peroneal nerves maintained at 37 degrees C conducted compound action potentials with only minor amplitude decreases at stimulus frequencies up to 200/sec. In contrast, nerves in EAN guinea-pigs maintained at 37 degrees C demonstrated a rapidly progressive decrease in action potential amplitude when stimulated as slowly as 10-25/sec. The decrease is greater the higher the frequency of stimulation. At 100 stimuli/sec all EAN preparations showed more than a 50% reduction in action potential amplitude. These effects are reversible. In pressure-injured frog sciatic nerves similar effects occurred at stimulus frequencies as low as 50/sec. Normal frog nerves conducted up to 200 impulses/sec with little amplitude decrease. The probable mechanism and clinical significance of these results are discussed. PMID- 4340435 TI - Liver lysosomes in congenital osteopetrosis. A study of lysosomal function, calcitonin, parathyroid hormone, and 3',5'-adenosine monophosphate. PMID- 4340436 TI - Uncertain role of cytosine arabinoside in varicella infection of compromised hosts. PMID- 4340437 TI - [Effect of angiotensin on cirrhotics]. PMID- 4340438 TI - [Renin-angiotensin-aldosterone system in water-electrolyte homeostasis]. PMID- 4340439 TI - Genetic engineering and cancer chemotherapy. PMID- 4340441 TI - Study of plasticity of neurone populations in model situations. PMID- 4340440 TI - Integrated therapy in the treatment of ovarian cancer with surgery, radiation and chemotherapy. PMID- 4340442 TI - Gluconeogenesis in rat kidney after partial hepatectomy. PMID- 4340444 TI - [Biological research on certain parainfluenza viruses. Adaptation to chick embryo]. PMID- 4340443 TI - Cytomegalovirus infection and disease in children: present state of knowledge. PMID- 4340445 TI - Selective demonstration of the variant hepatic artery. PMID- 4340446 TI - Neoplasms of the minor and lesser major salivary glands. PMID- 4340447 TI - The effect of 5-ethyl-2-deoxyuridine (EDU) on the fine structure of rabbit corneal epithelium in herpetic keratitis. PMID- 4340448 TI - Community control of amebic disease by periodic mass treatment with metronidazole. PMID- 4340449 TI - Hepatitis-associated (Australia) antigen in Nigerians: an ultrastructural study. PMID- 4340450 TI - Experimental transmission of Japanese encephalitis virus by Culex fuscocephala. PMID- 4340451 TI - [Simultaneous determination of lead and cadmium in blood and urine by coupling of ion exchange resin chromatography and atomic absorption spectrophotometry]. PMID- 4340452 TI - Interspecies differences in the occurrence of theta. PMID- 4340453 TI - Fine structural events correlated with progestin secretion during luteinization of rhesus monkey granulosa cells in culture. PMID- 4340454 TI - Glycogen content in the vaginal tissue of normally cycling and estrogen and progesterone-treated rhesus monkeys. PMID- 4340455 TI - [Primary culture in monolayer of differentiated liver cells of the rat dispersed by means of trypsinization. II. Cytomorphology]. PMID- 4340456 TI - The in vivo neuropharmacology of amino-oxyacetic acid in the cerebral cortex of the cat. PMID- 4340457 TI - Inhibition of unit activity in the hypothalamic paraventricular nucleus following antidromic activation. PMID- 4340458 TI - High affinity uptake systems for glycine, glutamic and aspaspartic acids in synaptosomes of rat central nervous tissues. PMID- 4340460 TI - Selective accumulation of ( 3 H)GABA by stellate cells in rat cerebellar cortex in vivo. PMID- 4340459 TI - Cyclic AMP in brain areas: effects of amphetamine and norepinephrine assessed through the use of microwave radiation as a means of tissue fixation. PMID- 4340461 TI - The cyclic AMP (adenosine 3',5'-phosphate) content of sciatic nerve: changes after nerve crush. PMID- 4340462 TI - The influence of semicarbazide-induced depletion of -aminobutyric acid on presynaptic inhibition. PMID- 4340464 TI - The effect of the neuronal excitant N-methyl-D-aspartate on the metabolism of mouse brain amino acids labelled from ( 14 C)bicarbonate and L-(U- 14 C)aspartate. PMID- 4340463 TI - The effect of the GABA antagonists bicuculline and picrotoxin on primary afferent terminal excitability. PMID- 4340465 TI - Effects of picrotoxin and strychnine upon electrical activity of the proximal retina. PMID- 4340466 TI - Ipsilateral and contralateral inhibitory actions on transmission through the spinocervical tract. PMID- 4340467 TI - Effects of prolonged perceptual isolation on the human electroencephalogram. PMID- 4340469 TI - [Synovial basement membrane]. PMID- 4340468 TI - The regulation of phosphofructokinase in muscle. PMID- 4340470 TI - [Diurnal rhythm of ACTH releasing factor activity]. PMID- 4340472 TI - The morphogenesis of poliovirus. PMID- 4340471 TI - [Lysine-8-vasopressin test as a simple method of hypothalamo-pituitary adrenal function]. PMID- 4340473 TI - [Comparative studies on the action of Marek's vaccine under simulated field conditions]. PMID- 4340474 TI - [Comparative experiments on the action of Marek vaccine under simulated field conditions]. PMID- 4340475 TI - Kinetic studies of the interaction of pigeon-liver NAD kinase with adenine nucleotides and divalent cations. PMID- 4340476 TI - Membrane-bound cyclic AMP phosphodiesterase in chemotactically responding cells of Dictyostelium discoideum. PMID- 4340477 TI - The lysines in liver alcohol dehydrogenase. Chemical modification with pyridoxal 5'-phosphate and methyl picolinimidate. PMID- 4340478 TI - 3':5'-cyclic nucleotide phosphodiesterases in rat tissues. PMID- 4340479 TI - [Course of immunity in subjects repeatedly vaccinated with Sabin virus]. PMID- 4340480 TI - [Concentration of poliomyelitis and influenza viruses studied with insoluble polyelectrolytes. Preliminary note]. PMID- 4340481 TI - [Epidemiology of poliomyelitis among the school population of Genoa after introduction of Sabin vaccination. Virological and serological studies during the period 1967-70]. PMID- 4340482 TI - [Poliovirus circulation and the immunological status of school children in Alessandria after the introduction of Sabin vaccination]. PMID- 4340483 TI - [Cutaneous, disseminated herpes complicated by staphylococcal superinfecction: case report]. PMID- 4340484 TI - Peripheral polyneuropathy in bilharziasis. PMID- 4340485 TI - Intestinal schistosomiasis a comparative therapeutic trial. PMID- 4340486 TI - Glycogen synthetase (UDP glucose: -1,4-glucan -4-glucosyl transferase (EC 2.4.1.11) I and D interconversion in the normal human epidermis. PMID- 4340487 TI - The enzymes of glycogen metabolism in the various cell fractions from the normal human epidermis. PMID- 4340489 TI - The administration of quinestrol to postmenopausal women. PMID- 4340488 TI - Adenosine 3',5'-cyclic monophosphate-stimulated protein kinase from human skin. II. Isolation and properties of multiple forms. PMID- 4340490 TI - [My experience with birth of an abnormal infant and home visits of the patient]. PMID- 4340492 TI - An input-output relation at the synapse between hair cells and eighth nerve fibers in goldfish. PMID- 4340493 TI - [Japanese encephalitis vaccine]. PMID- 4340491 TI - Quantal nature of transmission at the synapse between hair cells and eighth nerve fibers. PMID- 4340495 TI - [Statistical assessment of bone age and other prenatal growth parameters]. PMID- 4340494 TI - [Temperature and activity of the smooth muscle--with special reference to effects of temperature on contraction and ion transfer]. PMID- 4340496 TI - Renal hypertension. PMID- 4340497 TI - ACTH VS. CRF-like secretion by tumors. PMID- 4340498 TI - Apomorphine and its effects on the spinal cord. PMID- 4340499 TI - Effects of -radiation on a silica-trypsin compound suspended in aqueous buffer. PMID- 4340500 TI - [Electron microscopic observation of phagocytosis by invagination in Entamoeba histolytica]. PMID- 4340501 TI - [Electron microscopic observations of phagocytosis of Crithidia spec. by Entamoeba histolytica]. PMID- 4340503 TI - Effects of hydrocortisone on murine hepatitis virus replication and cell injury in cultured liver cells and macrophages. PMID- 4340502 TI - [Effect of some hormones and various physical factors on the osmotic resistance of leukocytes]. PMID- 4340504 TI - [Acetylcholinesterase activity in the supraoptic and paraventricular nuclei of the hypothalamus in conditions of depression of the adrenocorticotropic function of the hypophysis]. PMID- 4340505 TI - [Study of limbic epileptic discharges during paradoxical sleep]. PMID- 4340506 TI - [Adrenocortical response to an acoustic neurotropic stress: influence of the frequency and repetition of the stimulus]. PMID- 4340507 TI - Angiotensin II: local renal effects of physiological increments in concentration. PMID- 4340508 TI - Human gastric mucosa. I. The preparation of a glycopolypeptide and some aspects of its structure. PMID- 4340509 TI - Creatine phosphokinase in cerebrospinal fluid. PMID- 4340510 TI - Peripheral sensory neuropathy in childhood. PMID- 4340511 TI - [Biochemical aspects of the pathogenesis of cholera]. PMID- 4340512 TI - Clostridium histolyticum collagenase. II. Partial characterization. PMID- 4340513 TI - The amino-acid and carbohydrate sequences of a short glycopeptide isolated from bovine kappa-casein. PMID- 4340514 TI - Stimulation of labeling of rat-liver nuclear ribonucleic acid by insulin. PMID- 4340515 TI - Models for the interpretation of allosteric inhibition of Candida utilis fructose bisphosphatase by adenosine monophosphate. PMID- 4340516 TI - The effect of diethylpyrocarbonate on some physical and chemical properties of ceruloplasmin. PMID- 4340518 TI - [In vitro-behaviour of clones of giant cell tumors experimentally induced in the central nervous system of dog and rat]. PMID- 4340517 TI - [Enzyme histochemical findings in repeatedly transplanted rat nerve tumors]. PMID- 4340519 TI - [Effect of mineral corticoid (desoxycorticosterone acetate) on exocrine pancreas activity]. PMID- 4340520 TI - [Serotherapy of the gas gangrene]. PMID- 4340521 TI - [Case of tracheal cylindroma. Note on surgical technic]. PMID- 4340523 TI - [The contraceptive pill and blood pressure]. PMID- 4340524 TI - The separation of purine and pyrimidine bases and nucleosides by thin-layer chromatography on Sephadex-cellulose and Sephadex-silica gel layers. PMID- 4340525 TI - The use of polyamide for thin-layer chromatographic separation of steroids. PMID- 4340526 TI - [Experimental studies on enzyme histochemical changes in the olfactory system of Ambystoma mexicanum following unilateral resection of the olfactory organ]. PMID- 4340527 TI - Effects of prolonged treatment with 25-hydroxycholecalciferol in hypophosphatemic (vitamin D refractory) rickets and osteomalacia. PMID- 4340528 TI - Inhibition of mineralization by hydrolysates of phytic acid. PMID- 4340529 TI - Comments on the episodic function of the pituitary gland. PMID- 4340522 TI - The demonstration and function of antibodies in the gastrointestinal tract. PMID- 4340530 TI - [Effect of reserpine on cardiac and renal changes in hypercalcemia]. PMID- 4340531 TI - Pelvic angiography and hysterosalpingography in diagnosis of trophoblastic neoplasia. PMID- 4340532 TI - [Particles on the membrane of contractile vacuoles in Porterioochromas stipitata]. PMID- 4340533 TI - Stimulation of aldosterone production in vitro and its inhibition by spironolactone. PMID- 4340534 TI - Rat adrenal cyclic nucleotide-phosphodiesterase; inhibition by drugs known to affect steroidogenesis. PMID- 4340535 TI - [Diagnosis of liver cancer by hepatic angiography]. PMID- 4340536 TI - [Diagnosis and ultrastructure of the tubular carcinoma of salivary gland ducts. Epithelial-myoepithelial carcinoma of the intercalated ducts]. PMID- 4340537 TI - Triple primary malignant neoplasms: uterus, caecum and stomach. PMID- 4340538 TI - [Occurrence of Salmonella R plasmides]. PMID- 4340539 TI - [The diagnostic value of the EGG during sleep in temporal lobe epilepsy. Comparative registration by scalp and deep electrodes]. PMID- 4340540 TI - [Pituitary tumors treated by stereotaxic surgery]. PMID- 4340542 TI - Immunosuppression and cancer. PMID- 4340541 TI - Effects of choline-deficient diets on the rat hepatocyte. Electron microscopic observations. PMID- 4340543 TI - Tumour specific and embryonic antigen expression of chemically induced rat tumours. PMID- 4340545 TI - [Antigenic systems of tumors and leukemias induced by oncornaviruses]. PMID- 4340544 TI - [Antigenic modifications induced by Papova viruses]. PMID- 4340546 TI - [Problems posed by the immunological properties common to Burkitt's lymphoma and cancer. Means of resolving them]. PMID- 4340547 TI - [Immunology of mammary tumors]. PMID- 4340548 TI - [Immunology of brain tumors: the glial carcino-fetal antigen]. PMID- 4340549 TI - [Study of alpha-fetoprotein in human pathology. Present status of the question]. PMID- 4340550 TI - [Study of the symptom of CO 2 sensitivity induced by the vesicular stomatitis virus in Drosophila melanogaster. II. VSV Indiana serotype]. PMID- 4340551 TI - [Inert gas narcosis in conditions of environmental hyperbarism: review of the most important aspects of the world literature]. PMID- 4340552 TI - Vestibular stimulation during sleep in young adults. PMID- 4340553 TI - The -glycerophosphate cycle in Drosophila melanogaster. I. Biochemical and developmental aspects. PMID- 4340554 TI - Codon-anticodon interaction studied with oligonucleotides containing 3 deazauridine, 4 -deoxyuridine or 3 -deaza- 4 -deoxyuridine. I. Synthesis by primer-dependent polynucleotide phosphorylase of oligonucleotides containing modofied nucleosides. PMID- 4340555 TI - A common change of aspartyl-tRNA in polyoma- and SV40 -transformed cells. PMID- 4340556 TI - Inhibition of labeling of messenger and nucleoplasmic RNA of HeLa cells by camptothecin. PMID- 4340557 TI - Tumor cell sap factor stimulating orotate incorporation into nucleic acids in ascites hepatoma cells. PMID- 4340558 TI - [Vascular effect of eledoisin and cerulein in man and animals]. PMID- 4340559 TI - Pancreatic-like ribonuclease activity in the ascites fluid of the Novikoff and Ehrlich tumors. PMID- 4340560 TI - [Electron microscopy studies on the viral pathogenesis of lupus erythematosus]. PMID- 4340561 TI - The effect of vasoactive agents on stress-induced gastric hemorrhage in the rat. PMID- 4340562 TI - [Study of transglobular effects in lysozyme by the method of spin labels]. PMID- 4340564 TI - State of oxidation-reduction and state of binding in the cytosolic NADH-system as disclosed by equilibration with extracellular lactate-pyruvate in hemoglobin-free perfused rat liver. PMID- 4340563 TI - Properties and function of the pyruvate-formate-lyase reaction in clostridiae. PMID- 4340565 TI - Mono- and divalent cationic parameters of foot-and-mouth disease virus replicase. PMID- 4340566 TI - [Physiopathological principles in the treatment of orthostatic hypotension using mineralocorticoids]. PMID- 4340568 TI - Preparation of 7-aminocephalosporanic acid and 6-aminopenicillanic acid. PMID- 4340567 TI - Studies on tuberactinomycin. 3. Isolation and characterization of two minor components, tuberactinomycin B and tuberactinomycin O. PMID- 4340569 TI - Synthesis and antiprotozoal activity of methylnitro derivatives of 2,2' biimidazole. PMID- 4340570 TI - [Features of the radiation pathomorphosis of mucoepidermoid tumors and cylindromas of the parotid gland]. PMID- 4340571 TI - [Rare benign vascular cutaneous tumors, semi-malignant and malignant. Clinical behavior, histological aspects and classification]. PMID- 4340572 TI - Separation of Epstein-Barr virus DNA from large chromosomal DNA in non-virus producing cells. PMID- 4340573 TI - Cyclic AMP affects macrophage migration. PMID- 4340574 TI - Blocking of lymphocyte-mediated cytotoxicity for rat hepatoma cells by tumour specific antigen-antibody complexes. PMID- 4340575 TI - Mammary tumour virus specific nucleotide sequences in mouse DNA. PMID- 4340576 TI - [Lower respiratory tract diseases, caused by Adenovirus, in a pediatric ward]. PMID- 4340577 TI - [Paget tumor of the breast]. PMID- 4340578 TI - [Use of 2 methods (thermoresistance and culture in hypotonic media) suitable for distinguishing the thermoadaptability of strains of Entamoeba histolytica]. PMID- 4340579 TI - [Isolation of a thermo-adaptable strain of Entamoeba histolytica]. PMID- 4340580 TI - [Synacthen depot in the treatment of some dermatological diseases]. PMID- 4340581 TI - [Krukenberg's tumor secondary to primary cancer of the breast]. PMID- 4340582 TI - [Possible x-ray manifestations of cancer of the greater curvature of the stomach]. PMID- 4340583 TI - [Early immunity stages following inoculation of pigs with a foot-and-mouth disease DEAE dextran vaccine]. PMID- 4340584 TI - [Causes of the resistance to Shope's fibroma and herpes viruses of the cells of carcinoma induced by Shope's papilloma virus in the domestic rabbit]. PMID- 4340585 TI - [Biosynthesis of glycoproteins in animals with a myxovirus infection. I. Study of liver and spleen microsomal glucosaminyl-transferases]. PMID- 4340586 TI - [Study of an African Capparidacease, Buchholzia coriacea Engler]. PMID- 4340587 TI - [Physicochemical properties of the degradation products of 6-aminopenicillanic acid. Penicieic acid]. PMID- 4340588 TI - [Physicochemical properties of degradation products of 6-aminopenicillanic acid. D-4-carboxy-5,5-dimethyl-2-aminomethylthiazolidine]. PMID- 4340589 TI - [Antibiotic sensitivity and transference of the R-factor to Pasteurella multocida]. PMID- 4340590 TI - [Synergistic and antagonistic effect of combinations of antibacterial drugs on typhoid bacteria sensitive and resistant to antibiotics]. PMID- 4340591 TI - [Long-acting synthetic ACTH in the treatment of skin diseases]. PMID- 4340592 TI - [Favorable course of 2 cases of nodular prurigo treated by synthetic ACTH and corticosteroids]. PMID- 4340593 TI - The severe toxic reactions of antimony treatment of bilharziasis. PMID- 4340594 TI - [Diurnal fluctuations of CRF (corticotropin releasing factor) activities in bilaterally adrenalectomized and hypophysectomized rats]. PMID- 4340595 TI - [Examination of the action mechanism of synthetic LH-RF (luteinzing hormone releasing factor) by radioimmunoassay of cyclic AMP]. PMID- 4340596 TI - [ACTH bioassay--effect of unilateral adrenalectomy and ligation of renal vessels]. PMID- 4340598 TI - [Treatment of peripheral neurogenic disorders by excitatory motor currents]. PMID- 4340599 TI - [Electrologic aspect of botulism: 5 cases]. PMID- 4340601 TI - [Electromyographic correlations in Morton's disease and sciatic radiculopathy]. PMID- 4340600 TI - [Electrophysiology of striated muscle]. PMID- 4340602 TI - [Value of sensitive electrologic exploration in Thomas Morton's disease]. PMID- 4340603 TI - Radioimmunoassay of ovine beta-lipotropic hormone. PMID- 4340604 TI - Evidence for autonomous pituitary-adrenal function in the near-term fetal rhesus (Macaca mulatta). PMID- 4340605 TI - Dietary and hormonal regulation of hepatic biosynthetic and catabolic enzymes of serine metabolism in rats. PMID- 4340606 TI - Blood pressure response and antibody formation in spontaneously hypertensive rats and normal albino rats after immunization against angiotensin II. PMID- 4340607 TI - Effect of hormones on accumulation of cyclic AMP-14C in isolated pancreatic islets of rats. PMID- 4340597 TI - Levodopa: a review of its pharmacological properties and therapeutic use with particular reference to Parkinsonism. PMID- 4340609 TI - Further studies on the relationship between cycl AMP levels and adrenocortical activity. PMID- 4340608 TI - The effect of adrenocorticotrophic hormone on sulfate metabolism in the rat adrenal gland. PMID- 4340610 TI - The effect of prostaglandins on ACTH secretion. PMID- 4340611 TI - The effect of medium composition and in vitro stimuli on the conversion of corticosterone to aldosterone in rat glomerulosa tissue. PMID- 4340612 TI - Corticosteroid feedback control of ACTH secretion: rapid effects of bilateral adrenalectomy on plasma ACTH in the rat. PMID- 4340613 TI - Steroidogenesis in isolated adrenal cells of rat. 3. Morphological and biochemical correlation of cholesterol and cholesterol ester content in ACTH and N6-2'-O-dibutyryl-adenosine-3',5'-monophosphate activated adrenal cells. PMID- 4340615 TI - [Genetic markers of local poliovirus strains isolated during 1966-1969]. PMID- 4340616 TI - Use of benzamidine as a proteolytic inhibitor in the radioimmunoassay of glucagon in plasma. PMID- 4340617 TI - The rapid production of antisera to ACTH, angiotensin II, and deoxycorticosterone with sufficient sensitivity for use in radioimmunoassays. PMID- 4340618 TI - [Biosynthesis of androgens by a virilizing adrenal tumor]. PMID- 4340619 TI - Response patterns in vasoconstrictors to the skin and muscles upon stimulation of skin receptors in chronically spinalized cats. PMID- 4340620 TI - Effects upon the somato-sympathetic reflex transmission in spinalized cats. PMID- 4340622 TI - [Resting and action potentials of Nitella mucronata (A. Braun) Miguel]. PMID- 4340621 TI - Reduction of the early inward sodium and calcium currents of Aplysia neurons by ethanol. PMID- 4340623 TI - [Muscle contraction cycles and changes in configuraion of the cross bridges using pyrophosphate instead of ATP?]. PMID- 4340624 TI - The interaction of segmental and central inputs on single human alpha motor neurons. PMID- 4340625 TI - [Firing pattern decerebration of single Renshaw cells before and after and following treatment with the antispastic drug lioresal]. PMID- 4340626 TI - Ions and the electrical activity of the rat cerebral cortex. PMID- 4340627 TI - [Time constants of feline retinal ganglion cells]. PMID- 4340628 TI - [Modifications of signal transmission in the feline corpus geniculatum lat. (CGL) following stimulation of the formatio retic. mesenc. (FR)]. PMID- 4340629 TI - Blocking of the efferent endings in the cat's cochlea. PMID- 4340630 TI - [The positive ionotropic effect of dibutyryl-3',5'-AMP on isolated rat atria]. PMID- 4340632 TI - [A new symptom enabling differential diagnosis between vascular and radicular pain in the lower limb]. PMID- 4340631 TI - A quantitative analysis of the motoneuronal depression produced by increasing the stimulus parameters of afferent tetanization. PMID- 4340634 TI - [Cyclic adenosine 3',5'-monophosphate]. PMID- 4340633 TI - [Adenosine-3',5'-monophosphate and control of gene activity in animals]. PMID- 4340635 TI - Viral infectivity or oncogenicity due to viruses in hamsters. PMID- 4340637 TI - [Malignant tumors of the submaxillary gland. Apropos of a new case]. PMID- 4340638 TI - [Humoral and neural control of adenyl cyclase]. PMID- 4340636 TI - Intra- and extraosseous malignant histiocytoma (malignant fibrous xanthoma). PMID- 4340640 TI - [Recent contributions to the understanding of congenital abnormalities of the cervico-occipital joint]. PMID- 4340641 TI - [Mixed tumor]. PMID- 4340639 TI - [Greenish blue man. Primary amyloidosis. Tyrosinuria]. PMID- 4340642 TI - Nature of the bond between partial-thickness skin and wound granulations. PMID- 4340643 TI - [The value of methods of increased sensitivity for detecting alpha-fetoprotein in the diagnosis of primary liver cancer]. PMID- 4340644 TI - [Tissue respiration enzymes, absorption and storage of iron in latent iron deficiency]. PMID- 4340645 TI - [Clinical characteristics and general principles of treatment of viral pneumonias]. PMID- 4340646 TI - [Features of lipolysis and several lipid and carbohydrate metabolism interrelationships under normal conditions, in atherosclerosis, and in diabetes mellitus]. PMID- 4340647 TI - The relationship of cholesterol biosynthesis to cancer. PMID- 4340648 TI - [Germ-free animals and experimental oncology]. PMID- 4340649 TI - [Neoantigens and virus-tumors: finding and localization of neoantigens in virus transformed fibrosarcoma cells of the golden hamster]. PMID- 4340650 TI - Effect of bilateral nephrectomy on the renin activity of blood vessel walls. PMID- 4340651 TI - Facilitation and inhibition of facial reflexes in the cat induced by peripheral stimulation. PMID- 4340652 TI - Reciprocal inhibition during the stretch reflex. PMID- 4340653 TI - Adrenergic and nonadrenergic axons of the rabbit uterus and oviduct. PMID- 4340654 TI - Recurrent depression from motor axon collaterals of supraspinal inhibition in motoneurones. PMID- 4340655 TI - Effects of colchicine, vinblastine and vincristine on degeneration transmitter release after sympathetic denervation studied in the conscious rat. PMID- 4340656 TI - The little league pitcher. PMID- 4340657 TI - Diethyl ether anesthesia for a patient with hyperinsulinism. PMID- 4340658 TI - The "switch process" in manic-depressive illness. II. Relationship to catecholamines, REM sleep, and drugs. PMID- 4340659 TI - REM activity as a correlate of mood changes throughout the night. Electroencephalographic sleep patterns in a patient with a 48-hour cyclic mood disorder. PMID- 4340660 TI - Hereditary muscular dystrophy of the chicken. Quantitative histopathological findings of the Pectoralis at 6 weeks of age. PMID- 4340661 TI - Salivary gland lesions in children. A survey of 430 cases. PMID- 4340662 TI - Epithelioid sarcoma. A light and electron microscopic study suggesting a synovial origin. PMID- 4340663 TI - Ultrastructure of a sclerosing hemangioma of the lung. PMID- 4340664 TI - The sleep-waking cycle. PMID- 4340665 TI - Immunohistological, ultrastructural and biochemical investigations of human insulinomas. PMID- 4340666 TI - Adrenocortical activity in complicated and uncomplicated diabetes. PMID- 4340667 TI - Insulin secretion in children with adrenogenital syndrome treated with low doses of oral hydrocortisone. PMID- 4340668 TI - Species differences in the regulation of gluconeogenesis by the isolated perfused liver. PMID- 4340669 TI - Growth hormone releasing effects of ACTH and -MSH in man. PMID- 4340670 TI - Hormonal and nutritional effects on protein kinase activity in normal and hypophysectomized rats. PMID- 4340671 TI - Hypoglycemia due to hyperinsulinism treated by streptozotocin and diazoxide. PMID- 4340672 TI - Stabilization of motor nerve terminal membranes by insulin. PMID- 4340673 TI - A comparison of the toxicity of ergocalciferol and cholecalciferol in rhesus monkeys (Macaca mulatta). PMID- 4340675 TI - Freeze-etch studies of protein bodies in wheat scutellum. PMID- 4340676 TI - An investigation of serum lipoprotein disc electrophoresis. II. A simple method of human serum lipoprotein disc electrophoresis and identification of the resolved lipoproteins. PMID- 4340674 TI - Developmental studies in Drosophila. VI. Ultrastructural analysis of the salivary glands of Drosophila pseudoobscura during the late larval period. PMID- 4340677 TI - A study of hypertension. The effects of angiotensin II on the MAO activity and roles of calcium ion on the catecholamine contents in the rat hypothalamus and striatum. PMID- 4340678 TI - [Adrenal gland secretion in hypoxia: simultaneous observation on the adrenal cortex and adrenal medulla]. PMID- 4340679 TI - Tissue culture of rat ascites hepatoma AH-601 cells. PMID- 4340680 TI - [Malignant mixed mesodermal tumor of the urogenital tract: report of a case developing in a patient with transitional cell carcinoma of the urinary bladder and discussion on its entity]. PMID- 4340681 TI - Isolation of a strain of infectious bovine rhinotracheitis virus from aborted fetuses. PMID- 4340682 TI - Detection of precipitating antibody in equine infectious anemia by concentrated virus antigen. PMID- 4340683 TI - Inclusion-body rhinitis of swine occurring in Japan. PMID- 4340684 TI - [The behavior and role of cyclic adenosine monophosphate in the myocardium during acute ischemia]. PMID- 4340686 TI - [Cataleptic attacks and minor hysterical crises in epileptics and psychoneurotics. Clinical and polyphysiographic study of 30 cases]. PMID- 4340687 TI - [Nocturnal sleep in Ramsay-Hunt syndrome]. PMID- 4340685 TI - [The biochemical basis of nerve trophics]. PMID- 4340689 TI - Evidence of cell damage in rat salivary glands after isoproterenol. PMID- 4340688 TI - [Care for rheumatic patients after discharge from hospital]. PMID- 4340691 TI - [Development of immunological response in children living in closed children communities to adenoviral nosocomial infection in their 1st years of life]. PMID- 4340692 TI - Automated vitamin C analysis. PMID- 4340690 TI - The effect of vaccination with a live attenuated strain of Japanese encephalitis virus on stillbirths in swine in Taiwan. AB - Since an excellent candidate strain (M) for live virus vaccination of swine against Japanese encephalitis was developed, a number of large vaccination programmes have been implemented in Japan with the aim of controlling Japanese encephalitis epidemics in man by reducing the population size of nonimmune swine. Encouraging results have been obtained but no studies have been made on the benefits of live-virus vaccination to the industry. In order to determine the effect of vaccination upon the number of stillbirths occurring in the Japanese encephalitis post-emergence season, a total of 74 vaccinated, and subsequently mated, gilts at a large breeding farm in subtropical Taiwan were subjected to follow-up observations in comparison with a control group. The total incidence of litter stillbirths in the vaccinated group (1/74) was significantly lower than that in the control group (21/68). Over 92% of the newborn piglets from the vaccinated gilts were healthy, while 31.6-54.1% of the newborn piglets in the control groups were stillborn. The litter size of vaccinated gilts was larger than that of the control gilts. The vaccine was shown by tests in 22 swine to have an adequate degree of safety. Four weeks after vaccination with either 10(5.6) or 10(8.0) smicLD(50) of virus, all the swine developed an adequate level of antibody. The results indicate that live virus vaccination could benefit the industry in addition to achieving the main aim of controlling Japanese encephalitis viraemia in swine. PMID- 4340693 TI - [Motor conduction rate of the median nerve from the fossa axillaris to the elbow]. PMID- 4340694 TI - [Electrologic aspect of infraclinical neuropathy associated with alcoholism]. PMID- 4340695 TI - Regional cerebral blood flow and intraventricular pressure in acute brain injuries. PMID- 4340696 TI - Determination of the transfer ratio of cat's geniculate neurons through quasi intracellular recordings and the relation with the level of alertness. PMID- 4340697 TI - Deafness and peripheral neuropathy following carbon monoxide intoxication--report of a case. PMID- 4340698 TI - Bovine infectious keratoconjunctivitis: Moraxella bovis as the sole etiologic agent in a winter epizootic. PMID- 4340699 TI - Purification and properties of yeast nicotinamide adenine dinucleotide synthetase. PMID- 4340701 TI - Purification of a complex of alkaline fructose 1,6-bisphosphatase and phosphoribulokinase from Rhodospirillum rubrum. PMID- 4340700 TI - Subcellular distribution of and epinephrine-induced changes in hormone-sensitive lipase, phosphorylase, and phosphorylase kinase in rat adipocytes. PMID- 4340702 TI - Electron transport in Neurospora mitochondria. Studies on wild type and poky. PMID- 4340703 TI - Oxidative phosphorylation in Neurospora mitochondria. Studies on wild type, poky, and chloramphenicol-induced wild type. PMID- 4340704 TI - Studies on polynucleotides. CI. Escherichia coli tyrosine and formylmethionine transfer ribonucleic acids: effect of chemical modification of 4-thiouridine to uridine on their biological properties. PMID- 4340705 TI - Evidence for regulatin of cholesterol and fatty acid synthesis in liver by cyclic adenosine 3',5'-monophosphate. PMID- 4340706 TI - Cholinergic transmission in the recurrent facilitatory pathway of the spinal motoneuron of the toad. PMID- 4340708 TI - Immunization of rats against the Yoshida ascites hepatoma with viable cells injected subcutaneously or intramuscularly. PMID- 4340707 TI - Calcium metabolism in tumors. Its relationship with chromium complex accumulation. II. Calcium, magnesium and phosphorus in human and animal tumors. PMID- 4340709 TI - [Inhibition of neural acetylcholine release in the human ventricle myocardium by graduated tetrodotoxin poisoning]. PMID- 4340710 TI - [Activity of spinal respiratory neurons at various CO 2 -tension levels]. PMID- 4340711 TI - [Effects on respiration of electrical stimulation of the lateral surface of the cervical spinal cord]. PMID- 4340712 TI - [Stimulation and suppression of sodium transport in the rat cecum]. PMID- 4340713 TI - Localization of action of cholera toxin in epithelial cells of rabbit intestine. PMID- 4340714 TI - [Activation of renin in the juxtaglomerular apparatus by tubular sodium in the macula densa segment]. PMID- 4340716 TI - [Afferent stimulation of canine myocardial nerves and its effect on the heart rate. Is the path of cardial afferent stimuli in the N. depressor?]. PMID- 4340715 TI - [Analysis and reaction behavior of localized angiotensinase (N) in the juxtaglomerular apparatus of the rat kidney]. PMID- 4340717 TI - [Virilizing ovarian tumors: arrhenoblastoma]. PMID- 4340718 TI - Sleep changes during chronic administration of parachlorophenylalanine. PMID- 4340719 TI - [Portocaval transposition in experimental nephrogenous hypertension]. PMID- 4340720 TI - [Arrhenoblastoma]. PMID- 4340721 TI - Virus antibody levels in rheumatoid arthritis and systemic lupus erythematosus. PMID- 4340722 TI - Plasma corticosteroids in Cushing's syndrome. PMID- 4340724 TI - Bacteriologically proved pertussis and adenovirus infection. Possible association. PMID- 4340723 TI - Correlation of liver function and structure of cirrhosis with and without hepatoma based on autopsy studies. PMID- 4340725 TI - Failure of catch-up growth after Cushing's syndrome in childhood. PMID- 4340726 TI - Hydroxyindole-producing tumors of the pancreas. Carcinoid-islet cell tumor and oat cell carcinoma. PMID- 4340727 TI - The clinical choice of sedative-hypnotics. PMID- 4340728 TI - The concept and significance of growth rates in human pulmonary tumors. PMID- 4340729 TI - Cyclic-AMP and noradrenaline iontophoretic release on rat cerebellar Purkinje neurons. PMID- 4340730 TI - Central effects of amines in adult fowls. PMID- 4340731 TI - Serotoninergic neurotransmission and morphine activity. PMID- 4340732 TI - In vitro stimulation of enzyme secretion and the synthesis of microsomal membranes in the pancreas of the guinea pig. PMID- 4340733 TI - Cholinergic neurotransmission in the central nervous system. PMID- 4340734 TI - Dopamine and lumbar ganglionic transmission in the dog. PMID- 4340736 TI - [Mechanisms of inhibition in the central nervous system]. PMID- 4340735 TI - [A recent case of aniridia-nephroblastoma association]. PMID- 4340737 TI - [Snail agglutinins in tumor immunology]. PMID- 4340738 TI - [Observations on a case of ectopic ACTH syndrome in the course of pulmonary microcytoma]. PMID- 4340740 TI - Secondary radical processes in conalbumin irradiated in the dry state. PMID- 4340741 TI - Host-cell reactivation in mammalian cells. II. Survival of herpes simplex virus and vaccinia virus in normal human and xeroderma pigmentosum cells. PMID- 4340742 TI - Host-cell reactivation in mammalian cells. 3. Effect of caffeine on herpes virus survival. PMID- 4340743 TI - Temperature dependence of the survival of U.V.-irradiated herpes virus. PMID- 4340739 TI - Electron microscopic localization of hydrolytic enzymes in osteoclasts. PMID- 4340744 TI - Radioprotective effect of prostaglandin and an inhibitor of cyclic nucleotide phosphodiesterase on mammalian cells in culture. PMID- 4340745 TI - Electron spin resonance study of radicals produced in irradiated aqueous solutions of 5-halouracils. PMID- 4340747 TI - Detection of RNA-instructed DNA polymerase and high molecular weight RNA in malignant tissue. AB - An experimental procedure is detailed that permits the detection of 70S RNA directed DNA synthesis in mouse mammary carcinomas. The DNA synthesized is complementary to the RNA of the mouse mammary tumor virus by molecular hybridization, thus, completing the proof that an RNA-instructed DNA polymerase has been identified. Further, RNA-instructed DNA polymerase and its 70S RNA template are physically associated in a particle that has a density characteristic of oncornaviruses. These experiments now provide the technology required to perform similar examinations of human neoplasias. PMID- 4340746 TI - Effect of cyclic AMP on morphine analgesia tolerance and physical dependence. PMID- 4340748 TI - A fluorescent analog of nicotinamide adenine dinucleotide. AB - Nicotinamide 1,N(6)-ethenoadenine dinucleotide, a fluorescent analog of the coenzyme nicotinamide adenine dinucleotide, has been synthesized by the reaction of chloroacetaldehyde with the coenzyme. The technical fluorescence emission maximum of the analog is 410 nm, upon excitation at 300 nm. Its fluorescence yield is about 8% of that of the 1,N(6)-ethenoadenine 5'-phosphate, and its fluorescence lifteime is shorter. Upon hydrolysis of the modified coenzyme analog with Neurospora crassa NADase or phosphodiesterase I at room temperature, the intensity of fluorescence was increased 10-fold, corresponding to separation of the nicotinamide and ethenoadenine rings. The spectroscopic results with nicotinamide 1,N(6)-ethenoadenine dinucleotide are consistent with the concept of an intramolecular interaction between the modified adenine and pyridine moieties of the dinucleotide that is disrupted by enzymatic hydrolysis. The fluorescent analog showed reasonable activity as a substitute for NAD(+) in four different dehydrogenase-catalyzed reactions. PMID- 4340749 TI - Loss of simian virus 40 DNA-RNA hybrids from nitrocellulose membranes; implications for the study of virus--host DNA interactions. AB - Complete hybrids of simian virus 40 (SV40)DNA and its complementary RNA (cRNA) are not retained on nitrocellulose membranes. At saturating cRNA concentrations, retention of the hybrids indicates incomplete homology between DNA and RNA, probably due to incorporation of host DNA in the viral DNA; this effect is most pronounced when DNA is produced in cells infected at high multiplicity. Hybrids between DNA of Chinese hamster cells transformed by SV40 and cRNA are retained if the DNA fragments are long, but they are lost if the DNA is sheared to less than the length of an SV40 DNA molecule. Hence, in cells examined with about six SV40 genomes per cell, each genome is individually integrated. The results may explain previous discrepancies in the estimation of the number of viral genomes in transformed cells. PMID- 4340750 TI - Spin-orbital probes of biomolecular structure. A model DNA-acridine system. AB - Heavy atoms, such as bromine or iodine, perturb the excited-state properties of aromatic chromophores through a spin-orbital coupling mechanism. In the present work the use of specifically directed spin-orbital probes to study subtle structural relationships in biopolymers is described. Heavy atoms are introduced into defined sites in biochemical systems and the emission spectrum of a ligand or intrinsic chromophore is monitored for perturbation by the bound heavy atom. This technique is illustrated by a study of acridine dye binding to the copolymer poly(dA-BrdU). The results are interpreted in terms of an "externally" bound dye fraction whose emission is perturbed by the heavy atom in the polymer and an intercalated dye component unperturbed by bromine. PMID- 4340751 TI - Activation of C-type RNA virus markers in mouse uterine tissue. AB - Synthetic estrogenic compounds, both steroidal and nonsteroidal, and radiation activate markers of C-type virus information in mouse uterine tissue. Both the group-specific viral antigen and the RNA-directed DNA polymerase can be detected within 4 days after stimulation. These observations strengthen the concept of host-modified control mechanisms for expression of C-type virus markers. PMID- 4340752 TI - Studies on the mechanism of action of nerve growth factor. AB - In this study, explanted chick-embryo sensory ganglia were treated with nerve growth factor, and cellular concentrations of neurotubule protein were measured chemically by a colchicine-binding assay. Even after brief time periods, ganglia treated with growth factor were enriched in neurotubule protein, as compared with untreated (control) ganglia. Furthermore, studies with ganglia treated with both vincristine and growth factor demonstrated that neurotubule protein synthesis can occur even though neurite outgrowth is abolished. Several lines of evidence indicate that the growth factor stimulates de novo synthesis of neurotubule subunit protein, and that this effect precedes neurite extension. Like nerve growth factor, dibutyryl cyclic AMP also stimulates neurite outgrowth from embryonic sensory ganglia, yet it does not increase neurotubule protein levels. Available information suggests that the ability of growth factor to elicit rapid neurite outgrowth is closely related to its ability to increase cellular neurotubule levels. Cyclic AMP appears to stimulate neurite outgrowth by a different mechanism. PMID- 4340754 TI - Isolation and characterization of a protein that stimulates DNA synthesis from avian myeloblastosis virus. AB - A protein has been isolated from avian myeloblastosis virus that stimulates the rate and yield of DNA synthesis primed by viral RNA with purified viral polymerase. It specifically affects the viral polymerase and does not stimulate other DNA polymerases under the conditions tested. The viral polymerase, in conjunction with this protein, transcribes extended single-stranded regions of DNA, and permits the enzyme to initiate synthesis from single-strand breaks in DNA. PMID- 4340756 TI - Metabolic actions in human bronchial muscle associated with ACTH induced relaxation. PMID- 4340755 TI - [Study of the effect of UV-radiation on the collagen of animal skin connective tissue using the ESR method]. PMID- 4340757 TI - A neural quantum in sensory discrimination. PMID- 4340753 TI - Control of transcription of RNA rich in polyadenylic acid in human lymphocytes. AB - Rapidly labeled polyribosomal RNA rich in poly(A) has been isolated from cultures of highly purified human peripheral blood lymphocytes. Messenger RNA function for this RNA is suggested by its ability to direct [3H]Met-tRNA binding to ribosomes and incorporation of amino acids into protein in a cell-free preparation. Phytohemagglutinin and low concentrations of dibutyryl cAMP (40 nM) increase poly(A)-rich RNA synthesis 40% within 2 hr, and 100-300% by 12 hr; the percent poly(A) content and the size of the poly(A)-rich portion remain constant. Higher concentrations of dibutyryl cAMP (1 nM), which prevent morphological transformation of lymphocytes by phytohemagglutinin, inhibit synthesis of poly(A) rich RNA in phytohemagglutinin-treated lymphocytes without damaging cells. Cortisol (0.1 mM), which also prevents lymphocyte transformation, inhibits poly(A)-rich RNA synthesis by 80%. Cycloheximide (5 micro/ml), which decreases protein synthesis by 90%, decreases poly(A)-rich RNA synthesis 80% in cells stimulated by phytohemagglutinin. These studies demonstrate that, as part of the early molecular events of their action, phytohemagglutinin and cortisol regulate transcription of adenylate-rich RNA in human lymphocytes, and that similar transcriptional effects can be produced by dibutyryl cAMP. PMID- 4340758 TI - Mouse leukemia: depression of serum interferon production. AB - Production of circulating interferon is significantly impaired in AKR/J mice after development of lymphoblastic leukemia and in Balb/c mice with clinical signs of Friend erythroblastic leukemia. This alteration has been observed with three interferon inducers, each one known to elicit an interferon response in different cells. PMID- 4340759 TI - Neuroblastoma: synchronization of neurite outgrowth in cultures grown on collagen. AB - Neurite outgrowth in cultured neuroblastoma cells is inhibited in cells grown on a collagen substratum as compared to those grown on glass. Rapid, synchronized initiation of neurite outgrowth occurs after hydrolysis of the underlying collagen with collagenase. Axonated cultures exhibit an increased RNA and protein content as compared to cultures grown on collagen. PMID- 4340760 TI - Dibutyryl cyclic adenosine monophosphate stimulation of colcemid-inhibited axonal elongation. AB - Adenosine 3',5'-monophosphate (cyclic AMP) and its dibutyryl derivative induce a variety of morphological changes, including those associated with in vitro axonal maturation. Established sensory ganglia treated with dibutyryl cyclic AMP show significant increases in average axonal length and number in comparison with controls; those treated with maintenance doses of Colcemid show no increases in either parameter; simultaneous treatment with both agents results in growth statistically similar to that produced by dibutyryl cyclic AMP alone. The data are consistent with our hypothesis that cyclic AMP promotes axonal elongation by stimulating microtubule assembly from a preexisting subunit pool. PMID- 4340761 TI - [Rat serum proteins typical of liver regeneration and hepatoma]. PMID- 4340762 TI - The effect of some inhibitors on the activities of some organisms, responsible for gassiness in soft cheese. PMID- 4340763 TI - The reflexive fighting in septal rats. PMID- 4340764 TI - [A contribution to the determination of pyrophosphatase activity in bones]. PMID- 4340765 TI - [Properties of a high molecular arylamidase phosphatase complex from rat kidney microsomes]. PMID- 4340766 TI - Acid phosphatase active fluoride sensitive neurons in the white matter of the spinal cord. PMID- 4340767 TI - Ultrastructural cytochemistry of enzymes associated with mouse mammary tumour virus (MTV). PMID- 4340768 TI - [Enzyme demonstration in semi-thin sections]. PMID- 4340769 TI - [Effect of potassium on histochemically detectable liver enzymes]. PMID- 4340771 TI - [Course and prognosis of gastric leiomyoblastoma (myoid tumors). Review of 5 cases]. PMID- 4340770 TI - [Quantitative histochemical studies on the DNA-content of facultative and obligatory precanceroses of the skin. The DNA-content of so-called obligatory precanceroses]. PMID- 4340772 TI - [Histology and histochemistry of the guinea pig cochlea following stapedectomy]. PMID- 4340773 TI - [Effect of ear glomangioma growth tendencies on their treatment]. PMID- 4340774 TI - [Chances in the dark cells of the Crista ampullaris following streptomycin medication of guinea pigs]. PMID- 4340775 TI - [Histochemical enzyme studies on the function of root cells]. PMID- 4340776 TI - D(-)-lactate dehydrogenase from Allomyces. Partial purification and allosteric properties. PMID- 4340777 TI - Nerve Root compression: correlation of electromyographic, myelographic, and surgical findings. PMID- 4340778 TI - Clinical evaluation of procarbazine and fluorouracil in advanced lung cancer. PMID- 4340779 TI - [Mulleroblastoma (apropos of 4 cases)]. PMID- 4340781 TI - Nuclear movement in Erysiphe graminis hordei. PMID- 4340780 TI - Isoprene-containing metabolites of Aspergillus amstelodami. PMID- 4340782 TI - Immuno-electron microscopy of herpes simplex virus. PMID- 4340783 TI - Lysosomes and the "toxicity" of rickettsiales. 3. Response of L cells infected with egg-attenuated C. psittaci 6BC strain. PMID- 4340784 TI - Electron spin resonance studies on living cells. 3. Development of single individuals in Triturus alpestris. PMID- 4340785 TI - The effect of ethanol on the activity of some oxidative enzymes and on the ultrastructure of liver cells in the dog. PMID- 4340786 TI - [Mechanism of sympathetic post-ganglionic transmission]. PMID- 4340787 TI - [Acquired rheumatic streptococcal and viral valvulitis]. PMID- 4340788 TI - Metabolism of sphingosine bases, 18. Degradation in vitro of phytosphingosine (4d hydroxysphinganine). PMID- 4340789 TI - Effects of thyroglobulin on thyroid function. PMID- 4340791 TI - [Clinical-statistical studies on the problem of ulcercarcinoma of the stomach]. PMID- 4340790 TI - The effect of ACTH administration on aldosterone production in non salt-losing congenital adrenal hyperplasia. PMID- 4340792 TI - [Serum gamma glutamyl transpeptidase in hepatobiliary diseases. Comparison with alkaline phosphatase and aryl amidase]. PMID- 4340793 TI - Synthesis of DNA from vaccinia messenger RNA templates. PMID- 4340794 TI - A role of cyclic AMP in a neurotrophic process. PMID- 4340795 TI - Degradation of poliovirus polypeptides in vivo. PMID- 4340796 TI - Radical accumulation in liver microsomal membranes during biotransformation of aromatic amines and nitro compounds. PMID- 4340797 TI - Blockade of central 5-hydroxytryptamine receptors by methiothepin. PMID- 4340798 TI - Failure of angiotensin II to inhibit the uptake of noradrenaline by the catecholamine-depleted vas deferens of the rat. PMID- 4340799 TI - The application of improved techniques to the identification of strains of bluetongue virus. PMID- 4340800 TI - Macromolecular synthesis in bluetongue virus infected cells. I. Virus-specific ribonucleic acid synthesis. PMID- 4340801 TI - Macromolecular synthesis in bluetongue virus infected cells. II. Host cell metabolism. PMID- 4340802 TI - Failure to demonstrate in vitro as opposed to in vivo transcription of the bluetongue virus genome. PMID- 4340803 TI - [Health resort treatment in some diseases and sequelae of injuries to the weight bearing locomotor apparatus]. PMID- 4340804 TI - [Modern technics for evaluation of acoustic impedance in otology]. PMID- 4340805 TI - [Lysosomal pigment deposits in the kidney of old Wistar rats]. PMID- 4340806 TI - Pseudocrystalline inclusions in muscular endothelial cells. PMID- 4340808 TI - Methylation of adenine residues in bacteriophage T2 DNA containing cytosine in place of 5-hydroxymethylcytosine. PMID- 4340807 TI - Isolation and characterization of temperature-sensitive mutants of simian virus 40. PMID- 4340810 TI - The role of adenosine 3',5'-cyclic monophosphate in the growth of bacteriophage lambda. PMID- 4340809 TI - Identification of the nucleotide sequences of the oligonucleotides present in reovirions. PMID- 4340811 TI - The effect of high temperature on biological functions of three strains of SV-40. PMID- 4340813 TI - [Differential diagnostic problems of granulomas in the region of the parotid]. PMID- 4340812 TI - Primary structure of turnip yellow mosaic virus coat protein. PMID- 4340814 TI - Incontinentia pigmenti, Bloch-Sulzbergers syndrome, associated with infantile spasms. PMID- 4340815 TI - Insulinoma. Diagnostic problems in a 12-year-old boy. PMID- 4340816 TI - Bluetongue virus in goats. PMID- 4340817 TI - Effects of hydroxyurea on replication of infectious bovine rhinotracheitis virus in bovine kidney cells: an electron microscopic study. PMID- 4340818 TI - Storage of bluetongue virus-infected Culicoides variipennis. PMID- 4340819 TI - Bovine bluetongue: viral isolation from placentome and serologic survey in pregnant cows. PMID- 4340820 TI - [Brain lesions in cytomegalic disease with generalized inclusions in infants. Ultrastructural study of the virocytes]. PMID- 4340821 TI - [Skin metabolism disorders in psoriasis in children. Histochemical and electron microscopic studies]. PMID- 4340822 TI - [Cytomeglaic inclusion disease in the newborn. Apropos of 4 cases]. PMID- 4340823 TI - [Loganiaceae of the Ivory Coast. IX. Alkaloids of Strychnos camptoneura Gilg]. PMID- 4340824 TI - [Oculo-cerebello-myoclonic syndrome and neuroblastoma. Apropos of 2 cases]. PMID- 4340825 TI - The ultrastructure of the ciliary muscle of an old crab-eating monkey, with special reference to specific inclusions. PMID- 4340826 TI - Electron microscopic studies on the anterior lobe cells of the frog hypophysis, with special regard to the identification of the ACTH-cell. PMID- 4340827 TI - The influence of drugs affecting cyclic AMP levels on methadone induced potentiation of adrenaline effects. PMID- 4340828 TI - Optic nerve hypoplasia with good visual acuity. PMID- 4340829 TI - A rare cause of the chiasmal syndrome. PMID- 4340830 TI - [Classification of hyperlipidemias and hyperlipoproteinemias]. PMID- 4340831 TI - Ventromedial hypothalamic control of food intake and satiety: a reappraisal. PMID- 4340832 TI - Convergence of labyrinthine influences on units in the vestibular nuclei of the cat. II. Electrical stimulation. PMID- 4340833 TI - Effects of ACTH on the synthesis of rapidly labelled RNA in the nervous system of mice. PMID- 4340834 TI - Some aspects of the morphology of Betz cells in the cerebral cortex of the cat. PMID- 4340835 TI - Heterogeneity of synaptic vesicles in the squid giant fibre system. PMID- 4340836 TI - Enhanced sensitivity of caudate neurones to microiontophoretic injections of dopamine in 6-hydroxydopamine treated cats. PMID- 4340838 TI - Intracellular analysis of antidromically and synaptically activated lateral reticular neurons. PMID- 4340837 TI - Are vestibular nuclei responsible for rapid eye movements of paradoxical sleep? PMID- 4340839 TI - Inhibition of cerebellar climbing fibre activity by stimulation of precruciate cortex. PMID- 4340840 TI - Activation of reciporcal Ia inhibitory pathway during voluntary motor performance in man. PMID- 4340841 TI - Single unit responses to frequency-modulated tones and possible relationship to inhibitory effect of two-tone stimuli. PMID- 4340842 TI - Action of bicuculline on presynaptic inhibition of various origins in the cat's spinal cord. PMID- 4340843 TI - The effect of barbiturate anaesthesia on the transmission to the cerebellar cortex. PMID- 4340846 TI - Electron microscopic observation on the paraffin or celloidin-paraffin embedded secetions from surgical and autopsy materials. PMID- 4340844 TI - Polygraphic sleep pattern in newly hatched chickens: effects of noradrenaline and 6-hydroxydopamine. PMID- 4340845 TI - Cirrhosis and primary hepatic cancer in Peshawar, Pakistan. A geographic pathological study. PMID- 4340847 TI - Immunological investigation on transplantable rabbit tumor. PMID- 4340848 TI - [The effect of preparations for neuroleptoanalgesia on tissue preparations]. PMID- 4340849 TI - Snail albumin gland: a new source of proteinase inhibitors. PMID- 4340851 TI - Activation of hippocampal neurons by mossy fiber stimulation in thin brain sections in vitro. PMID- 4340850 TI - Autoradiographic identification of cerebral and cerebellar cortical neurons accumulating labeled gamma-aminobutyric acid ( 3 H-GABA). PMID- 4340853 TI - Rhythmic potentials originating in rat retina. PMID- 4340852 TI - Excitatory and inhibitory influences of thalamic stimulation on pyramidal tract neurons. PMID- 4340854 TI - Superficial gastric carcinoma simulating polypoid hypertrophic gastritis. PMID- 4340856 TI - [Phagocytic activity and neutrophil metabolic indices in iodine deficiency]. PMID- 4340857 TI - [Pigeons as models for the study of food poisoning caused by Clostridium perfringens type A]. PMID- 4340855 TI - Iatrogenic gastrointestinal diseases in the aged. PMID- 4340858 TI - Extracellular NAD as a cytostatic agent. PMID- 4340859 TI - [Specific modification of the coenzyme binding site of dehydorgenases by inhibition with the NAD analogue (3-(4-bromoacetylpyridinio)propyl)-adenosine pyrophosphate]. PMID- 4340860 TI - Alkaline phosphatase patterns in Dieldrin-treated dogs. PMID- 4340861 TI - A phase-electron microscopic study of extraocular muscle dystrophy in the mouse. PMID- 4340862 TI - Purification of corneal collagenases. PMID- 4340863 TI - Purification and properties of nicotinamide adenine dinucleotide-dependent D- and L- lactate dehydrogenases in a group N streptococcus. AB - Streptococcus lactis strain 760, a group N streptococcus, was found to possess nicotinamide adenine dinucleotide-dependent dehydrogenase activities for both the l(+) and the d(-) isomers of lactic acid. The two enzymes were isolated and purified and were found to differ with respect to pH optima, activation by fructose-1,6-diphosphate, pH and heat stability, and the temperature at which each enzyme was formed in the organism during growth. The presence of a racemase for lactic acid was not detected by the methods used. PMID- 4340864 TI - Factors affecting the activity of the lactate dehydrognease of Streptococcus cremoris. AB - Studies with partially purified extracts of the nicotinamide adenine dinucleotide linked l(+)-lactate dehydrogenase of Streptococcus cremoris US3 showed that fructose-1,6-diphosphate (FDP) was essential for the catalytic reduction of pyruvate in the pH range 5.0 to 7.0, outside of which the organism does not grow. In the absence of FDP, enzyme activity was observed only in the region of pH 8.0. The optimal pH for the oxidation of lactate was approximately 8.0 in the presence and absence of FDP. The FDP-activated enzyme was markedly inhibited by inorganic phosphate. The enzyme lost activity on standing at 5 C in alkaline triethanolamine, was quite stable at pH 6.0 to 6.5, and underwent irreversible denaturation below pH 5.0. Inorganic phosphate or FDP increased the stability of the enzyme in alkaline buffers. Some distinguishing properties of individual lactate dehydrogenases, activated by FDP, are discussed. PMID- 4340865 TI - Isolation and some properties of cell envelope altered mutants of Escherichia coli. AB - Mutants of Escherichia coli which have a defect in their permeability barrier were selected. The technique used was to employ a strain of E. coli having a deletion in the gene for lactose permease and to select for mutants which can grow on lactose at 40 C. Twenty such mutants were isolated and six of these were found to be more sensitive to actinomycin D, sodium deoxycholate, and sodium dodecyl sulfate than was the parental strain. They were also more sensitive to the antibiotics vancomycin and bacitracin, which inhibit peptidoglycan biosynthesis. These mutants were no more sensitive to several different colicins or phages than was the wild-type strain. One of the mutants selected by this technique has an abnormal morphology when grown on certain carbon sources in minimal medium, and this mutant is more extensively studied in the accompanying paper. PMID- 4340866 TI - Effects of acetate and other short-chain fatty acids on sugar and amino acid uptake of Bacillus subtilis. AB - Acetate and other short chain n-fatty acids (C(1)-C(6)) inhibit strongly the uptake of l-serine or other l-amino acids but inhibit only weakly that of alpha methylglucoside or fructose, whether measured in whole cells of Bacillus subtilis or in membrane vesicles that have been energized with reduced nicotinamide adenine dinucleotide (NADH), l-alpha-glycerol phosphate, or ascorbate plus phenazine methosulfate. The acetate inhibition is noncompetitive, as was shown for l-alpha-aminoisobutyric acid uptake by whole cells and for l-serine uptake by membrane vesicles. In membrane preparations, neither NADH oxidation nor the reduction of cytochromes by NADH are affected by fatty acids. All of these effects are similar to those of 2, 4-dinitrophenol. It is concluded that the fatty acids "uncouple" the amino acid carrier proteins from the cytochrome-linked electron transport system (to which they may be coupled via protein interaction or via a cation gradient). PMID- 4340867 TI - Intrauterine infection of the rhesus monkey with mumps virus: abbreviated viral replication in the immature fetus as an explanation for split immunologic recognition after birth. PMID- 4340869 TI - Herpes genitalis. PMID- 4340868 TI - [Basic study on the leukemogenic mechanism]. PMID- 4340870 TI - Nonspecific urethritis. PMID- 4340871 TI - Spontaneous subarachnoid hemorrhage. Initial presentation of brain tumors. PMID- 4340872 TI - Catechol O-methyltransferase. IV. Factors affecting m- and p-methylation of substituted catechols. PMID- 4340873 TI - The amino acid sequence of cytotoxin II from the venom of the Indian cobra (Naja naja). PMID- 4340874 TI - [Viral profile of multiple sclerosis. Study of virus complement fixing antibodies]. PMID- 4340875 TI - Bluetongue virus-induced interferon synthesis. PMID- 4340876 TI - Sleep patterns of pubertal males. PMID- 4340877 TI - Effect of antibiotics on respiration in human cells. PMID- 4340878 TI - [Application of standing-position plaster in cerebral palsy (indication, reasons, and technique)]. PMID- 4340879 TI - Study of antivirus activity of mineral condensed polyanions. II. Effect on vesicular stomatitis virus. PMID- 4340881 TI - [Problems posed by knee osteoarthritis during the development of Hodgkin's disease. Spontaneous remission during 30 months of lymphogranulomatosis]. PMID- 4340880 TI - [Inclusions in endothelial cells and lymphocytes in the course of a case of dermatomyositis]. PMID- 4340883 TI - [Bronchial foreign bodies in adults. Apropos of 9 cases]. PMID- 4340882 TI - [Urogenital bilharziasis. Apropos of 33 cases observed in 10 months in a general medicine department]. PMID- 4340886 TI - [Examination and treatment of suicidal behavior observed in a general medical department. Indications for individual and group consultations]. PMID- 4340884 TI - [Methods of transfusional therapy of chronic thrombopenia]. PMID- 4340885 TI - [Role of the psychiatrist in a general medicine department]. PMID- 4340888 TI - [Practical diagnostic procedure with respect to a radiological image of diffuse miliary pulmonary disease]. PMID- 4340887 TI - [Uricoeliminating or urico-inhibiting agents? Reasons for a choice]. PMID- 4340889 TI - Comparison of methods for diagnosing equine rhinopneumonitis virus abortion. PMID- 4340891 TI - [The nature of methyl-hydroperoxide complex II in catalase]. PMID- 4340892 TI - Rat liver glycerolphosphate dehydrogenases: activity changes and induction by thyroid hormone of the mitochondrial enzyme in hepatomas and in precancerous and growing liver. PMID- 4340890 TI - Bovine rhinotracheitis-parainfluenza-3 vaccine with Pasteurella bacterin as the diluent. PMID- 4340893 TI - [Measurement of NADH fluorescence for determining the effectiveness of mechanical energy liberation in the hypoxic myocardium]. PMID- 4340894 TI - [Autopsy cases of congenital abnormalities of the brain]. PMID- 4340895 TI - [Autopsy case of progressive multifocal leukoencephalopathy]. PMID- 4340897 TI - Amphetamine withdrawal: affective state, sleep patterns, and MHPG excretion. PMID- 4340896 TI - Correlation of virology and clinical course of cytomegalovirus retinitis. PMID- 4340900 TI - Dependence on ACTH. PMID- 4340899 TI - Thrombocytopenia with sodium cephalothin therapy. PMID- 4340898 TI - Type II congenital dyserythropoietic anemia. PMID- 4340901 TI - [Linkage studies in man. II. Loci of autosomal pathologic characteristics and serologic tracers]. PMID- 4340902 TI - [Distribution isoenzymes of lactate dehydrogenase in human brain neoplasms]. PMID- 4340903 TI - [Galactography--a method for the early diagnosis of ductal cancer of the female breast]. PMID- 4340904 TI - Fluorescent modification of adenosine-containing coenzymes. Biological activities and spectroscopic properties. PMID- 4340905 TI - Stereochemistry of the transesterification step of ribonuclease T 1 . PMID- 4340906 TI - Conformation of oligoinosinates: chain-length dependence and comparison to other oligonucleotides. PMID- 4340907 TI - The submicrosomal distribution of radioactive proteins released by puromycin from the bound ribosomes of rat liver microsomes labelled in vitro. PMID- 4340908 TI - [Distribution of copper in hepatic subcellular fractions after subacute copper poisoning in rats]. PMID- 4340909 TI - [Innovation in electron microscopic observation using single-layer ultra thin section of tissue culture materials]. PMID- 4340911 TI - [Optic nerve compression due to a voluminous ethmoido-sphenoidal mucocele]. PMID- 4340912 TI - The actions of polymyxin B and histamine on ganglionic transmission. PMID- 4340910 TI - [Treatment of malignant brain tumors by the intrathecal administration of BAR (EUdR-antimetabolite-radiation)]. PMID- 4340913 TI - The effect of phentolamine and other drugs on rat brain phosphodiesterase. PMID- 4340914 TI - [Nuclear bodies of keratinocytes]. PMID- 4340915 TI - The effect of changes in the respiratory metabolism upon genome activity in Drosophila. I. The induction of gene activity. PMID- 4340916 TI - Effect of lithium on plasma cortisol and adrenal response to adrenocorticotropin in man. PMID- 4340917 TI - [Cytomegalovirus infection and pregnancy. Results of a serological survey]. PMID- 4340920 TI - The effect of retinol and ergocalciferol on the activity of enzymes and stability of membranes of mitochondria. PMID- 4340919 TI - Glucose metabolism in normal human thyroid tissue in vitro. PMID- 4340918 TI - Measurement of plasma 25-hydroxycholecalciferol in man. PMID- 4340921 TI - Substrate specificity of farnesyl pyrophosphate synthetase. PMID- 4340922 TI - Isolation of minicircular deoxyribonucleic acids from wild strains of Escherichia coli and their relationship to other bacterial plasmids. AB - Supercoiled minicircular deoxyribonucleic acid (DNA) molecules with molecular weights of 1.8 x 10(6) and 2.3 x 10(6) have been isolated from two wild strains of Escherichia coli. DNA-DNA hybridization experiments indicate that these DNA molecules share extended homologies with the minicircular DNA of E. coli 15. The DNA of the colicinogenic factor E1 (ColE1) also hybridizes to a large extent with minicircular DNA of E. coli 15. In contrast, no hybridization could be detected with various large extrachromosomal DNA elements such as the colicinogenic factor V (ColV), the beta-hemolytic factor (Hly), or the P1-like DNA of E. coli 15. Two different insertion DNA species of E. coli integrated into lambdadg-DNA (lambdadg UP(in) 128, lambdadg UP(in) 308) do not show any annealing with minicircular DNA of E. coli 15. PMID- 4340923 TI - 3',5'-cyclic adenosine monophosphate-requiring mutants of Escherichia coli. AB - Mutants that require exogenous 3',5'-cyclic adenosine monophosphate (cAMP) for exponential growth were isolated from strains deficient in adenyl cyclase. Studies of one strain showed that cAMP is not incorporated into macromolecules; instead, it seems to have a regulatory function, i.e., in media lacking cAMP, cells form ribonucleic acid (RNA) and protein at linear rather than exponential rates. The exact lesion is not known; ribosomes, messenger RNA, and the beta and beta' subunits of RNA polymerase continue to be made in absence of added cAMP. PMID- 4340924 TI - Radial tunnel syndrome: resistant tennis elbow as a nerve entrapment. PMID- 4340925 TI - Isoprinosine: lack of antiviral activity in experimental model infections. PMID- 4340926 TI - Factors affecting the stability of transmissible enteritis virus of turkeys. PMID- 4340927 TI - Increased antibody to herpes simplex virus in patients with nasopharyngeal cancer. PMID- 4340928 TI - Rapid diagnosis of varicella-zoster infections by agar-gel diffusion. PMID- 4340929 TI - Inflammation and viral infection: chemotactic activity resulting from the interaction of antiviral antibody and complement with cells infected with herpes simplex virus. PMID- 4340930 TI - [Pathological study of toxic polyneuropathy. 3. Light and electron microscopic observations on regeneration of rat peripheral nerves in methyl mercury poisoning]. PMID- 4340931 TI - Histochemical studies on normal and diseased human and chick muscle in tissue culture. PMID- 4340932 TI - Habituation of blink reflexes in parkinsonian patients under levodopa and amantadine treatment. PMID- 4340933 TI - Grey matter edema: the marginal zone of autochthonous virally-induced gliomas. PMID- 4340934 TI - Idiopathic orthostatic hypotension. Report of an autopsied case with histochemical and ultrastructural studies of the neuronal inclusions. PMID- 4340935 TI - An evaluation of routine diagnostic procedures in cancer of the lung. PMID- 4340936 TI - [Relation between sudoral excretion of sodium and potassium and the renin angiotensin-aldosterone system in arterial hypertension]. PMID- 4340937 TI - [Increased angiotensinogen levels in malignant hypertension]. PMID- 4340938 TI - [Modifications of diuresis during angiotensin perfusion in the dog: leading role of hemodynamic conditions]. PMID- 4340939 TI - [Effect of exogenous angiotensin on superficial and juxtamedullary glomeruli in the rat. Scanning electron microscope study]. PMID- 4340940 TI - Cristo ocular and cristo spinal reflexes: a review after 1,000 cases of vertigo. PMID- 4340942 TI - Nerve entrapment and electromyography. PMID- 4340941 TI - Presurgical internal maxillary artery embolization in juvenile angiofibroma. PMID- 4340943 TI - Evidence for central norepinephrine-mediated inhibition of ACTH secretion in the rat. PMID- 4340945 TI - Are the eye movements of dreaming sleep related to the visual images of the dreams? PMID- 4340944 TI - Cyclic 3',5'-AMP phosphodiesterase in isolated fat cells. Simple and sensitive methods for the assay of phosphodiesterase activity in fat cells and studies of the enzyme inhibition by theophylline. PMID- 4340946 TI - Neonatal muscle tone recorded from eye movement leads. PMID- 4340947 TI - [Orthostatic hypotension without change in pulse rate. Hemodynamic study of an amyloid neuropathy and of a transitory idiopathic form]. PMID- 4340948 TI - [Ultrastructural study of Pick's disease. Apropos of 3 cases]. PMID- 4340950 TI - [Results of treatment of 821 breast cancers]. PMID- 4340949 TI - Broad-spectrum antiviral activity of Virazole: 1-beta-D-ribofuranosyl-1,2,4 triazole-3-carboxamide. AB - Virazole is a synthetic nucleoside active in tissue culture against at least 16 DNA and RNA viruses. Applied topically, it inhibits herpetic keratitis in rabbits and tail lesions induced by herpes, vaccinia, and vesicular stomatitis viruses in mice. Injected intraperitoneally into mice, it inhibits splenomegaly and hepatomegaly induced by Friend leukemia virus and respiratory infections caused by influenza A(O), A(2), and B viruses and parainfluenza 1 virus. infections is also effective. PMID- 4340951 TI - [Neoplasms of the floor of the mouth. Analysis of 70 cases]. PMID- 4340952 TI - [A case of highly differentiated adenocarcinoma of the uterine cervix. (Malignant adenoma of Anglo-Saxon authors)]. PMID- 4340953 TI - [Value and limitations of cytochemical studies of leukocyte metabolism during chemotherapy in patients with malignant blood disorders and hemosarcomas]. PMID- 4340954 TI - [Essential obesity and aglucidic dietetics]. PMID- 4340955 TI - [Erythema nodosum and typhoid fever]. PMID- 4340956 TI - [Aspects of myocardia caused by B1 hypovitaminosis observed in Abidjan]. PMID- 4340957 TI - [Kartagener syndrome and cardiovascular abnormalities]. PMID- 4340958 TI - [Influence of oral contraceptives on carbohydrate metabolism. Hormonal contraception and diabetes mellitus]. PMID- 4340960 TI - [Ischemic colitis]. PMID- 4340959 TI - [Contribution to the electro-clinical study of the effect of diazepam in Creutzfeldt-Jakob disease]. PMID- 4340961 TI - [Cytodiagnosis of bronchial cancers and its value]. PMID- 4340962 TI - [Surgical diarrhea]. PMID- 4340964 TI - [Anatomo-pathological aspect of subacute myelo-monocytic leukemia]. PMID- 4340965 TI - [Subacute myelo-monocytic leukemia. Cyto- and biochemical study of granulocytic and monocytic lines]. PMID- 4340963 TI - [Subacute myelo-monocytic leukemia. Study of 27 cases and review of the literature]. PMID- 4340966 TI - [Platelet function study in subacute myelo-monocytic leukemia and refractory anemia]. PMID- 4340967 TI - [Myelo-monocytic leukemia with sideroblastic anemia]. PMID- 4340968 TI - [Procedure to follow in a bullous disease]. PMID- 4340969 TI - [Health evaluations in children at 10 months, 2 years, 4 years. A new experience of preventive medicine organized by the Caisse Primaire Centrale d'Assurance Maladie of Paris]. PMID- 4340970 TI - Manifestations and prognosis of carcinoma of the liver. PMID- 4340972 TI - [Study of herpes simplex skin test in herpetic keratitis. I]. PMID- 4340971 TI - Prevention of neural and muscular lesions during hyperthermic regional perfusion. PMID- 4340973 TI - On the mechanism of amine oxidation by diamine oxidases. PMID- 4340974 TI - Mutation and cancer: neuroblastoma and pheochromocytoma. PMID- 4340975 TI - Leukocytic proteases and the immunologic release of lysosomal enzymes. PMID- 4340977 TI - Influence of halothane anaesthesia on blood glucose, plasma free fatty acids and thermoregulation in rats. PMID- 4340976 TI - Role of granulocyte collagenase in collagen degradation. PMID- 4340978 TI - Effect of morphine and codeine on tissue responses and kinetics of labelled choline and acetylcholine in normal and reserpinized guinea-pig ileum. PMID- 4340979 TI - [Colony inhibition test (C.I.T.) and the cytotoxic adherence test (C.A.T.): some comparative data]. PMID- 4340980 TI - [Possible anticholinesterase activity of the tetanus toxin]. PMID- 4340981 TI - [Etiological studies in cases of anterior acute poliomyelitis (AAP) verified in Umbria and in the Marche since the year 1964]. PMID- 4340982 TI - [Antipoliomyelitic neutralizing antibodies in persons of the Milan region aged 14 to 25 years]. PMID- 4340983 TI - [Circulation of the wild polioviruses]. PMID- 4340984 TI - [Incidence of cytopathogenic enteric viruses in Lombardy 5 years after the introduction of antipoliomyelitic vaccination with the Sabin vaccine]. PMID- 4340985 TI - [Presence and epidemiological significance of polioviruses in sewer waters in Pisa]. PMID- 4340986 TI - [Immunitary defense against polioviruses in various population samples in several years following Sabin vaccination]. PMID- 4340987 TI - [Detection of poliovirus carriers in the school population of Genoa, Savona and Alessandria from 1965 to 1969]. PMID- 4340988 TI - Lipid composition of subcellular fractions from rat testis. PMID- 4340989 TI - Mulitiple effects of cycloheximide on the metabolism of triglycerides in the liver of male and female rats. PMID- 4340990 TI - The presence of unusually high levels of lysophosphati-dylethanolamine in a wax ester-synthesizing copepod (Calanus Plumchrus). PMID- 4340991 TI - Positional distribution and turnover of fatty acids in phosphatidic acid, phosphinositides, phosphatidylcholine and phosphatidylethanolamine in rat brain in vivo. PMID- 4340992 TI - Lecithin: cholesterol acyltransferase: effects of substrate composition upon enzyme activity. PMID- 4340993 TI - Separation of binding proteins for cholecalciferol and 25-hydroxycholecalciferol from chick serum. PMID- 4340994 TI - [Reactions of leech neurons to puncture of the somatic membrane]. PMID- 4340996 TI - Familial occurrence of mild hyperlipoproteinaemias. PMID- 4340995 TI - Familial polysyndactyly and craniofacial anomalies. PMID- 4340997 TI - Antilipolytic action of insulin on fat cells. PMID- 4340998 TI - Insulin and glycogen synthase. PMID- 4340999 TI - Relationship of some hepatic actions of insulin to the intracellular level of cyclic adenylate. PMID- 4341000 TI - Action of insulin: an attempt at a summary. PMID- 4341001 TI - Proinsulin and C-peptide in blood. PMID- 4341003 TI - Insulin action at the molecular level. Facts and speculations. PMID- 4341002 TI - The circulating proinsulin-like components. PMID- 4341004 TI - Enucleation of mammalian cells by cytochalasin B. II. Formation of hybrid cells and heterokaryons by fusion of anucleate and nucleated cells. PMID- 4341005 TI - Effects of adenosine 3',5'-cyclic monophosphate on membrane potential, nuclear volume, and puff size in Drosophila salivary gland in vitro. PMID- 4341006 TI - Changes in susceptibility of normal cells to agglutination by plant lectins following modification of cell coat material. PMID- 4341007 TI - Inhibitors of cyclic-nucleotide phosphodiesterase induce morphological differentiation of mouse neuroblastoma cell culture. PMID- 4341008 TI - Effect of pH and serum on phosphate transport in BHK 21 and BHK 21 -polyoma transformed cells. PMID- 4341009 TI - A new general method for the synthesis of phosphate-protected deoxyribooligonucleotides. IV. PMID- 4341010 TI - A carbon-13 and hydrogen-1 nuclear magnetic resonance study of the conformations of 3',5'- and 2',3'-cyclic nucleotides. A demonstration of the angular dependence of three-bond spin-spin couplings between carbon and phosphorus. PMID- 4341011 TI - Liquid crystalline lipid in the plasma of humans with biliary obstruction. AB - Plasma lipoprotein characteristics were evaluated in a group of patients with obstructed biliary tracts. A 1:1 molar lecithin-free cholesterol liquid crystal phase was observed in the low density flotation region of these patients. The smectic nature of this mesophase was confirmed by electron microscopy, polarized microscopy, and low angle X-ray scattering. A small amount of protein was associated with these liquid crystals, some of which appeared to be components of normal very low and high density lipoproteins. The composition and physical properties of the very low and high density lipoproteins from these obstructed patients differed from normal as well. Aberrant apoprotein patterns were observed for both obstructed very low and high density lipoproteins. A beta electrophoretic migration was observed for a component of these two lipoprotein groups. PMID- 4341012 TI - The effect of Sendai virus infection on bactericidal and transport mechanisms of the murine lung. AB - Pulmonary virus infections predispose to bacterial infections in the lung. The mechanism of this effect was studied by quantitative comparison of the effects of airborne acute viral infection on pulmonary transport vs. in situ bactericidal mechanisms in mice. Animals infected by aerosol with 10(4) TCID(50) of Sendai virus developed pathologic pulmonary changes of interstitial pneumonitis, bronchial epithelial desquamation, and peribronchial mononuclear cell infiltration 7 days later. At that time, the mice were challenged with an aerosol of viable (32)P-labeled Staphylococcus aureus. Pulmonary bactericidal activity and physical transport by the lung were determined by the determination of viable staphylococcal and (32)P radiotracer counts respectively at 4, 24, 48, and 72 hr after bacterial challenge. Infected mice showed a significant decrease from normal in the rate of reduction of viable bacterial counts in the first 4 hr after challenge followed by a proliferation of the staphylococci. By contrast, radiotracer removal rates at 4 and 24 hr were similar in infected and noninfected mice. There was a small but significant retention of (32)P in the lungs of the infected animals at the later periods. These data demonstrate that bacterial multiplication associated with virus infection of lungs is related to defects in in situ bactericidal (phagocytic) mechanisms rather than transport mechanisms of the lung, despite histologic evidence of extensive destruction of bronchial ciliated epithelium. PMID- 4341013 TI - Mitochondrial lesions in reversible erythropoietic depression due to chloramphenicol. AB - The mechanism underlying the reversible depression of erythropoiesis by chloramphenicol has been investigated in rabbits in which hemolytic anemia had been induced by phenylhydrazine so that the compensatory erythroid hyperplasia would provide a situation where abnormalities in the bone marrow cells reflected predominantly those of erythroid precursors. Maintenance of chloramphenicol in the serum of these animals at concentrations in the order of 15 mug/ml resulted in erythropoietic depression after several days. The onset of this depression corresponded to the development of a cellular respiratory defect in the erythroid precursors which was associated with an abnormality in the composition of the mitochondrial respiratory pathway. The abnormality took the form of a selective depletion of cytochromes a + a(3) and b which can be explained by an inhibitory effect of the antibiotic on their formation by the mitochondrial protein synthesizing system. The relationship between the mitochondrial lesion and the depression of proliferative activity was further indicated by the correlation between the restoration of the cytochrome deficit and the recovery of erythropoiesis after chloramphenicol administration was ceased. The features of the reversible depression of erythropoiesis corresponded closely to those in man, so that a specific action of chloramphenicol on mitochondrial formation provides a reasonable explanation for this important manifestation of chloramphenicol toxicity. PMID- 4341014 TI - Plasma triglyceride metabolism in thyroid disease. AB - Plasma endogenous triglyceride transport kinetics were determined in 16 hyperthyroid and in 12 hypothyroid patients and the results compared with those of euthyroid control subjects. In addition, the removal of exogenous particulate fat (Intralipid; Vitrum, Sweden) from the circulation and the postheparin plasma lipolytic activity (PHLA) were studied in these patients for further characterization of the alterations of plasma triglyceride metabolism in thyroid disease. In thyrotoxicosis the average plasma triglyceride level was slightly but significantly increased above that of control subjects. This change was associated with augmented production of triglycerides whereas the mean fractional removal rate was not different from normal. There was a significant linear correlation between the concentration and turnover rate of plasma triglycerides in both hyperthyroid and euthyroid subjects but the concentration/turnover rate ratio was less in the former group suggesting that the efficiency of removal of triglycerides from the circulation was improved in thyroid hyperfunction. The elimination of intravenously administered particulate fat occurred more rapidly in untreated hyperthyroid patients than in euthyroid control subjects. The mean PHLA was also above normal in thyrotoxicosis. Upon adequate treatment of the hyperthyroid state the fasting plasma triglyceride concentration was further increased. Hypothyroid patients showed another pattern of alteration of triglyceride kinetics. The synthesis of plasma triglycerides was normal but the fractional removal of both endogenous and exogenous triglycerides was markedly reduced and this change seems to account for the hypertriglyceridemia associated with thyroid hypofunction. The plasma PHLA was also clearly decreased in the hypothyroid state. Plasma FFA and glycerol levels were increased in hyperthyroidism and plasma FFA was slightly decreased in hypothyroid patients, but these variables were not significantly correlated with any parameter of triglyceride metabolism. Endogenous triglyceride turnover rate was significantly correlated with serum protein-bound iodine (PBI) and T3 uptake in thyrotoxicosis but not in hypothyroidism. Removal of exogenous fat was not related to postheparin plasma lipolytic activity but the fractional endogenous triglyceride transport showed a highly significant relationship to this lipase activity in a mixed group of hyper- and hypothyroid patients. The results suggest that thyroid hormones control both production and removal of plasma triglycerides. Different mechanisms for these interactions are considered. PMID- 4341015 TI - Hepatic fructose-1,6-diphosphatase deficiency. A cause of lactic acidosis and hypoglycemia in infancy. AB - An 8-month-old female, maintained on breast feeding for 6 months, experienced numerous attacks of hyperventilation when weaned to baby food and was admitted with severe lactic acidosis (20 mM) and hypoglycemia. Physical examination was negative except for hepatomegaly. Fasting (18 hr) after stabilization on a high carbohydrate diet resulted in hypoglycemia (plasma glucose 40 mg/100 ml), lactic acidosis (6-10 mM), and a rise in plasma alanine. Glucagon produced a glycemic response after 6 hr, but not after 18 hr fasting. Intravenous galactose increased plasma glucose (Delta 45 mg/100 ml) but intravenous fructose, glycerol, and alanine caused a 40-50% fall in plasma glucose and a significant rise in lactate (Delta 3-4 mM). Liver biopsy showed fatty infiltration. Liver slices incubated with galactose, lactate, fructose, alanine, or glycerol converted only galactose to glucose. Hepatic glycolytic intermediates were increased below the level of fructose-1,6-diphosphate and decreased above. Hepatic phosphorylase, glucose-6 phosphatase, amylo-1,6-glucosidase, phosphofructokinase, fructose-1-phosphate aldolase, and fructose-1,6-diphosphate aldolase levels were normal, but no fructose-1,6-diphosphatase (FDPase) activity was detected. Further studies on the liver homogenate of this patient revealed the presence of an acid-precipitable activator of FDPase. Normal plasma glucose and lactate levels were maintained on an 800 cal diet of 66% carbohydrate (sucrose and fructose excluded). 5% protein, and 20% fat. When carbohydrate was reduced to 35% and protein or fat increased to 23 and 53% respectively, lactic acidosis and hypoglycemia recurred. These studies show that a deficiency of FDPase produced infantile lactic acidosis and hypoglycemia and can be controlled by an appropriate diet. PMID- 4341016 TI - Adrenal-pituitary influence in reactivation of avoidance-learning memory in the rat after intermediate intervals. PMID- 4341017 TI - Comparative recovery following simultaneous- and successive-stage frontal brain damage in mice. PMID- 4341018 TI - [Paths opened to medicine by the discovery of the cyclic nucleotides]. PMID- 4341019 TI - Group- and type-specific antigens in mouse leukaemia induced by Friend, Mazurenko and Rauscher viruses. PMID- 4341021 TI - [Role of the hypothalamus in regulation of the interaction of the mammary glands and the sexual organs]. PMID- 4341020 TI - Notes on some peculiarities of enzymic processes in malignant tumours and tissues of the host. PMID- 4341022 TI - DNA estimations in cerebral tumours of man. PMID- 4341023 TI - [Comparative studies concerning the activity and isoenzyme pattern of lactate dehydrogenase in spontaneous as well as experimental glioma of the brain]. PMID- 4341024 TI - Enzyme histochemical investigations of repeatedly transplanted brain and nerve tumours of the rat. PMID- 4341025 TI - A comparative histochemical study on the functional groups iin proteins and some oxidizing-reducing enzymes in reactive glia and glial tumours. I. Glial tumours. PMID- 4341026 TI - Contribution of enzyme histochemistry as to the nature and differences among mantle cells (satellite cells), amphicytes, and Schwann cells in remak fiber bundles and of myelinated fibers in dorsal root ganglia, sympathetic ganglia and in peripheral nerves of various animals. PMID- 4341027 TI - A comparative histochemical study on functional protein groups and some oxidizing reducing enzymes in reactive glia and glial tumours. II. Reactive glia. PMID- 4341028 TI - Some aspects of the histochemistry of the reactive glia. PMID- 4341029 TI - Some aspects of histochemistry of glia and ganglion cells of hypothalamus in the age aspects. PMID- 4341030 TI - Enzyme histochemical alterations following intracranial penetration of a microneedle. PMID- 4341032 TI - [Infectivity period of varicella and zoster in the light of virological examinations]. PMID- 4341031 TI - [Histoenzymology of the liver in experimental carbon tetrachloride poisoning of the rat]. PMID- 4341033 TI - Documentation of hand function with the use of office copying equipment. PMID- 4341034 TI - [Chorioadenoma destruens]. PMID- 4341035 TI - [Does a renin-angiotensin-aldosterone system exist?]. PMID- 4341036 TI - [The oral metapiron test in children for the simultanous examination of ACTH and growth hormone secretion]. PMID- 4341037 TI - [Pathogenesis of acute non-infectious kidney failure in experimental and clinical studies]. PMID- 4341038 TI - [Significance of mammography and xeroradiography in the early diagnosis of breast carcinoma]. PMID- 4341039 TI - Erythrocytic enzyme activities in hypothyroid children. PMID- 4341040 TI - Zinc deficiency in man. The Shiraz experiment. PMID- 4341041 TI - Apparent cure of Cushing's disease by bilateral adrenalectomy and autotransplantation. PMID- 4341042 TI - [Virological research in acute respiratory diseases during 1969-70]. PMID- 4341043 TI - [Characterization of a cell strain derived from a hamster tumor induced with the hybrid PARA-adenovirus 7]. PMID- 4341044 TI - [Behavior of cell lines transformed by polyoma virus maintained at high incubation temperature (+41 degrees C)]. PMID- 4341045 TI - Depression of adrenergic transmission by a factor in renal venous blood: new evidence for an antihypertensive function of the kidney. PMID- 4341046 TI - Mechanism of hydroxylation of aromatic compounds: evidence for the involvement of superoxide anion in a model system. PMID- 4341048 TI - The ribosomal subunit requirements for GTP hydrolysis by reticulocyte polypeptide elongation factors EF-1 and EF-2. PMID- 4341049 TI - Squalene synthetase. I. Dissociation and reassociation of enzyme complex. PMID- 4341047 TI - Partial characterization of an -bungarotoxin-binding component of electroplax membranes. PMID- 4341050 TI - Aldehyde dehydrogenase activity in a rat hepatoma. PMID- 4341051 TI - A differential effect of adenosine 3', 5'-cyclic monophosphate on the synthesis of functional enzymes from two different cistrons of the LAC operon. PMID- 4341052 TI - Chemical and physical properties of foot-and-mouth disease virus: a comparison with Maus Elberfeld virus. PMID- 4341053 TI - Enzymatic epoxidation. I. Alkene epoxidation by the -hydroxylation system of Pseudomonas oleovorans. PMID- 4341054 TI - The role of polypeptide antibiotics on the bacterial differentiation. PMID- 4341055 TI - Collagenase in carcinoma cells. PMID- 4341056 TI - Isolation and identification of the virus-specified RNA species found on membrane bound polyribosomes of chick embryo cells infected with Semliki Forest virus. PMID- 4341057 TI - Heme-heme interactions in cytochrome c oxidase: effects of photodissociation of the CO compound. PMID- 4341058 TI - Polydeoxythymidylate inhibition of rabbit reticulocyte RNA dependent protein synthesis in a Krebs II ascites cell system. PMID- 4341059 TI - [Effect of amino acids on the growth of Bacillus polymyxa var. Ross and on the formation of polymyxin M]. PMID- 4341060 TI - [Is mammary cancer in mice a model for breast cancer in women?]. PMID- 4341061 TI - [Diagnosis of the nature of retroperitoneal tumors in children. Value of selective and complete renal arteriography]. PMID- 4341062 TI - Studies on inherited antigenic variation of human serum beta-lipoprotein by passive hemagglutination. VI. Screening for antibodies in sera from multiparous women and from normal individuals. PMID- 4341063 TI - Studies on the protein moiety of serum high density lipoprotein from patients with familial lecithin: cholesterol acyltransferase deficiency. PMID- 4341064 TI - Studies on inherited antigenic variation of human serum beta-lipoprotein by passive hemagglutination. VII. Isoantibodies in sera from children with thalassaemia. PMID- 4341065 TI - Cerebral blood flow and membrane ionic pump. PMID- 4341066 TI - The effect of hyperventilation on CBF. PMID- 4341067 TI - Hypertensive cerebral microinfarction and cerebrovascular reactivity. PMID- 4341068 TI - [Cell membrane function. 1. Effect of CC1-4 administration on NADH-cytochrome c reductase activity in rat liver cell membrane]. PMID- 4341069 TI - [Cell membrane function. 2. Contamination of the cell membrane fractions of the CC1-4 treat rat liver by subcellular particles]. PMID- 4341071 TI - [Cell membrane function. 5. Effect of sex hormones on NADH-cytochrome c reductase activity in rat liver cell membrane]. PMID- 4341070 TI - [Cell membrane function. 4. Enzymatic characterization of the NADH-cytochrome c reductase of the cell membrane from normal and CC1-4 treated rat liver]. PMID- 4341072 TI - [Cell membrane function. 6. Differences in solubility of electron transport enzymes in rat liver cell membranes and microsomes and the effect of CC1-4 administration]. PMID- 4341074 TI - [Nephroscintigraphy using a commercially prepared 99m-technetium-iron complex]. PMID- 4341073 TI - Determination of the age of wounds by histochemical and biochemical methods. PMID- 4341075 TI - [Functional nephrography]. PMID- 4341076 TI - [Studies on regional pulmonary function using 133xenon in patients with chronic bronchitis]. PMID- 4341077 TI - [99m-Tc microspheres for scintigraphic representation of the lungs]. PMID- 4341078 TI - [The scancamera--a new system for localization diagnosis in nuclear medicine]. PMID- 4341079 TI - [A positron camera with electronic data processing]. PMID- 4341080 TI - [Possibilities for activation analysis in medicine]. PMID- 4341081 TI - [Bases for the use of activatable indicators]. PMID- 4341082 TI - [Normal values of essential and nonessential trace elements in human serum in correlation with age factors and serum albumin concentration]. PMID- 4341083 TI - [Radiochemical separation methods in activation analysis of biologic material]. PMID- 4341084 TI - [Determination of 9 trace elements in female blood serum using neutron activation analysis]. PMID- 4341085 TI - [Influence of neoplasm growth on the plasma copper and ceruloplasmin levels in the rat]. PMID- 4341086 TI - [Influence of transplanted neoplasms of the rat on manganese concentration in the liver and on the distribution of 54Mn]. PMID- 4341087 TI - [Determination of age dependence of trace element concentrations in human cerebral cortex and basal ganglia]. PMID- 4341088 TI - [Experimental studies on the biopositive effect of laser rays]. PMID- 4341089 TI - [Studies on ozone treatment and radiosensitization of Crocker sarcoma 180 of mice]. PMID- 4341090 TI - [Animal experiments on the effect of an antiphlogistic agent in local radiation reactions]. PMID- 4341091 TI - [Varying influence of photons and fast electrons on human bone marrow in vitro]. PMID- 4341092 TI - [Experimental results in radiochemotherapy using L-asparaginase]. PMID- 4341093 TI - [Molecular basis of radiosensitization]. PMID- 4341095 TI - [Cellular aspects of radiosensitization]. PMID- 4341094 TI - [Biochemical effect of certain radiation-sensitizing agents]. PMID- 4341096 TI - [Dependence of cellular radiosensitivity on Ca ++ -ions]. PMID- 4341097 TI - [Radiosensitization of cells in vitro]. PMID- 4341098 TI - [Results of animal experiments on radiosensitization in partial or whole-body radiation]. PMID- 4341099 TI - [Effect of some radiosensitizing agents on the dynamics of 24 Na and 42 K in the dog]. PMID- 4341100 TI - [Experimental findings on the sensitization mechanism of riboflavin]. PMID- 4341102 TI - [Radiotherapy following synchronization and its theoretical prerequisites]. PMID- 4341101 TI - [Clinical and experimental results of interstitial Curie-therapy combined with radiosensitizing agents in DS carcinoma of the rat and in infiltrating brain neoplasms]. PMID- 4341103 TI - [Radiosensitization using spindle poisons in mycosis fungoides]. PMID- 4341104 TI - [Sensitization in radiobiology and in radiotherapy]. PMID- 4341105 TI - Demonstration of a direct hydrogen transfer between NADH and a deazaflavin. PMID- 4341106 TI - [Subtotal clamping of the vena cava during extended right hepatectomy]. PMID- 4341108 TI - The activity of microtubules and microfilaments in neurulation in the chick. PMID- 4341107 TI - The effect of lorazepam on sleep. PMID- 4341109 TI - Migration of follicle cells through the zona pellucida and their sequestration by human oocytes in vitro. PMID- 4341110 TI - Usefulness of computer scintigraphy for detecting liver tumor with 67 Ga-citrate and the scintillation camera. PMID- 4341111 TI - [Female pseudohermaphroditism. A propos of 2 cases]. PMID- 4341112 TI - Simultaneous microassays of adenosine and adenosine 3', 5'-cyclic monophosphate in biological samples. PMID- 4341113 TI - Systemic manifestations of hepatoma. PMID- 4341114 TI - Neuropathy associated with lymphoma. PMID- 4341115 TI - Ultrastructural changes in the peripheral nerves in experimental dying-back polyneuropathies. PMID- 4341116 TI - Onion bulb formations in chronic polyneuropathies. PMID- 4341118 TI - Memory. PMID- 4341117 TI - Different cerebral scan characteristics of different cerebral pathologies: double isotope scanning. PMID- 4341120 TI - Further observations on an outbreak of diphenylhydantoin intoxication. PMID- 4341121 TI - Oxidative enzyme activity in single neurones in relation to selective vulnerability to ischaemia. PMID- 4341119 TI - Histochemical and biochemical studies in pseudohypoparathyroidism. PMID- 4341122 TI - [New understanding of immunologic control mechanisms of tumor growth]. PMID- 4341123 TI - [Immunity and immunotherapy in patients with trophoblastic choriocarcinoma]. PMID- 4341124 TI - Tumor associated immune reactions in cancer patients. PMID- 4341125 TI - Inhibition of angiotensin conversion in experimental renovascular hypertension. AB - Constriction of the renal artery and controlled reduction of renal perfusion pressure is followed by a prompt increase in systemic renin activity and a concomitant rise in blood pressure in trained, unanesthetized dogs. The elevated blood pressure induced by the renal artery stenosis can be prevented by prior treatment with the nonapeptide Pyr-Trp-Pro-Arg-Pro-Gln-Ile-Pro-Pro, which blocks conversion of angiotensin I to angiotensin II. Further, the nonapeptide can restore systemic pressure to normnal in the early phase of renovascular hypertension. These results offer strong evidence that the renin-angiotensin system is responsible for the initiation of hypertension in the unilaterally nephrectomized dog with renal artery constriction. PMID- 4341126 TI - Relation between REM sleep and intracranial self-stimulation. AB - Depriving rats of rapid eye movement (REM) sleep was shown to lower their thresholds and raise their response rates for rewarding brain stimulation. Conversely, allowing rats to self-stimulate while they were being deprived of this sleep form reduced the amount of REM rebound during recovery from deprivation. These results demonstrate a reciprocal relation between rewarding brain stimulation and REM sleep. PMID- 4341129 TI - [Viral inclusion body in vaginal smears]. PMID- 4341127 TI - Disintegration of the junctional epithelium of human fetal hard palate. PMID- 4341131 TI - [Australia antigen and chronic hepatic diseases in the western African]. PMID- 4341130 TI - Adenyl cyclase activity in kidneys of rats with lithium-induced polyuria. PMID- 4341132 TI - Bilateral vocal cord paralysis of undetermined etiology. Clinical course and outcome. PMID- 4341133 TI - Radiographic findings in adenoid cystic carcinoma of the head and neck. PMID- 4341134 TI - Tanning without sunburn with aminobenzoic acid-type sunscreen. PMID- 4341135 TI - Herpetic sycosis. Report of two cases. PMID- 4341136 TI - Recurring digital fibrous tumor of childhood. PMID- 4341137 TI - The black keratinous cyst. A sign of hemochromatosis. PMID- 4341138 TI - I (Inclusion) cell disease, Leroy's syndrome (arly alveolar ridge hypertrophy, joint limitation, thick, tight skin in early infancy). PMID- 4341139 TI - Chondroid syringoma. PMID- 4341140 TI - [Lymphographic exploration of the thoracic duct (radiologic and physiopathological study)]. PMID- 4341141 TI - [Programmed radiological diagnosis as a basis for the use of computers]. PMID- 4341142 TI - [Heart catheterization with continuous recording using a digital printer]. PMID- 4341143 TI - [Status of automatization of heart catheterization and angiocardiography]. PMID- 4341144 TI - [Significance of conventional radiodiagnostic methods in the diagnosis of inflammatory and malignant pancreatic diseases]. PMID- 4341145 TI - [Interpretation of radiodiagnostic parameters with a computer using a biostatic programming system]. PMID- 4341146 TI - [Electron data processing in radiotherapy]. PMID- 4341147 TI - [Electronic data processing in radiotherapy. Medical-clinical aspects]. PMID- 4341148 TI - [Use of the computer in radiotherapy]. PMID- 4341149 TI - [Radiotherapy planning and radiotherapy technology using an owned electronic data processing installation]. PMID- 4341150 TI - [Computer controlled optimation in intracavital Gamma therapy]. PMID- 4341151 TI - [Electronic data processing in nuclear medicine]. PMID- 4341152 TI - [Data processing in nuclear medicine]. PMID- 4341153 TI - [Mathematical evaluation for digital scintiscans]. PMID- 4341154 TI - [Significance of digital data processing for localization diagnosis in nuclear medicine]. PMID- 4341156 TI - [Radiodiagnosis--planning, construction and organization of modern medical radiation institutes]. PMID- 4341155 TI - [Planning, construction and organization of modern medical radiation institutes]. PMID- 4341157 TI - [Pediatric radiology]. PMID- 4341158 TI - [Neuroradiology]. PMID- 4341159 TI - [Planning, construction, and organization of modern medical institutes for radiotherapy]. PMID- 4341160 TI - [Planning, construction and organization of modern institutes for nuclear medicine]. PMID- 4341163 TI - [Influence of planning on technology]. PMID- 4341161 TI - [Standpoint of the architect in relation to the central institute for radiotherapy]. PMID- 4341162 TI - [Standpoint of the architect]. PMID- 4341164 TI - [Influence of technology on planning]. PMID- 4341165 TI - [Adaptation of planning and organization to the size of the hospital]. PMID- 4341166 TI - [Organization of the supraregional collaboration of radiology departments in hospitals of different size]. PMID- 4341167 TI - [Physical basis of image enhancement]. PMID- 4341168 TI - [Technique of image enhancement]. PMID- 4341169 TI - [Image enhancement and fluoroscopy]. PMID- 4341172 TI - [Luminous powder applications for studying the influence of the crystal size on the light density and image clarity]. PMID- 4341171 TI - [Relations between quantum density, grain size and photolysis]. PMID- 4341170 TI - [Image amplifier and photography]. PMID- 4341173 TI - [Radiograph amplifiers with improved qualities]. PMID- 4341174 TI - [Transmission quality of radiograph amplifiers and their significance in quantitative radiologic density measurement]. PMID- 4341175 TI - [Optic systems for image amplifiers]. PMID- 4341177 TI - [Photos from image amplifiers and image orientation]. PMID- 4341176 TI - [Cinecoronarography: exposure techniques using film]. PMID- 4341178 TI - [X-ray examination in the operating room]. PMID- 4341179 TI - [Studies on intraparenchymatous arteriolar circulation using radiographic projection with high radiation intensities]. PMID- 4341180 TI - [Photographic technique of the 70 mm video amplifier and the status of current installations]. PMID- 4341181 TI - [Dependence of image contrast on thickness of the object, picture potential and blacking in a largely monochromatic radiation spectrum]. PMID- 4341182 TI - [Surgery of acquired heart valve defects]. PMID- 4341183 TI - [Discussion on the choice of radiation quality in soft tissue radiographs]. PMID- 4341185 TI - [Siemens AG, area of medical technology]. PMID- 4341184 TI - [New indirect methods for the production of colored radiographs in order to improve the detail contrast]. PMID- 4341186 TI - [Special tomography apparatus, "Stratomatic"]. PMID- 4341187 TI - [Development and technology of scintigraphy]. PMID- 4341188 TI - [Interactive analysis of scintiscans using a computer projection screen of a computer (sound film)]. PMID- 4341189 TI - [Application of scintillation cameras to investigations in nuclear medicine]. PMID- 4341190 TI - [Evaluation of the biologic significance of bone metastases using 87mSr]. PMID- 4341191 TI - [Animal experiments for studying the incorporation of (al 18 F 6 ) 3- ]. PMID- 4341192 TI - [Pancreatic scintigraphy. Comparison of various organ activities following application of 75 Se Selenomethionine and pancreozymin]. PMID- 4341193 TI - [Study of salivary gland function using serial scintigraphy]. PMID- 4341194 TI - [Studies on diaplacentar transfer of radiotechnetium and radioindium]. PMID- 4341195 TI - [Postoperative radiological findings in acquired heart valve defects]. PMID- 4341196 TI - [Measurement of heart volume following surgery for mitral valve stenosis]. PMID- 4341197 TI - [Radiographic peculiarities of acquired heart valve defects in the child]. PMID- 4341198 TI - [Isotope diagnosis of acquired heart failure and cardiac insufficiency]. PMID- 4341199 TI - [Studies on cardiac stress insufficiency using radiocardiographic function analysis]. PMID- 4341200 TI - [Ultrasonic diagnosis of heart diseases]. PMID- 4341201 TI - [Comparative study on the results of heart catheterization and echocardiography]. PMID- 4341202 TI - [Levoangiocardiography and echocardiography for judgment of mitral valve failure]. PMID- 4341204 TI - [Selective coronary angiography in acquired heart valve defects]. PMID- 4341203 TI - [Angiocardiographic results in the syndrome of mesosystolic click with late systolic heart murmur]. PMID- 4341205 TI - [Problems of radiographic measurement of the heart volume in mass screening]. PMID- 4341207 TI - [Radiodiagnosis of the acute abdomen in childhood]. PMID- 4341206 TI - [Acute abdomen]. PMID- 4341208 TI - [Radiodiagnosis of acute gastrointestinal hemorrhage]. PMID- 4341209 TI - [Diagnostic possibilities of angiography in acute abdomen]. PMID- 4341210 TI - [Angiography in abdominal injuries]. PMID- 4341211 TI - [Radiodiagnosis of segmental intestinal infarction]. PMID- 4341212 TI - [Incomplete mesenteric vascular occlusion as possible cause of Crohn's regional enteritis]. PMID- 4341213 TI - [Atypical radiological signs in gastrointestinal perforation]. PMID- 4341215 TI - [Diagnosis of retroperitoneal neoplasms as causes of acute abdomen]. PMID- 4341214 TI - [Acute abdomen in intestinal parasitic diseases]. PMID- 4341216 TI - [Pharmacoarteriography of the pancreas using secretin, trypsin and histamine]. PMID- 4341217 TI - [Diagnosis and differential diagnosis of bone neoplasms of the skull]. PMID- 4341218 TI - [Tumor induced unspecific reactions of compact bone (radiological-histological synopsis)]. PMID- 4341219 TI - [Parosteal osteoid sarcoma]. PMID- 4341221 TI - [Radioclinical aspects of a case of Mafucci-syndrome]. PMID- 4341220 TI - [Diagnosis and treatment of ameloblastomas]. PMID- 4341222 TI - [Difficulties in the diagnosis of multiple mycloma]. PMID- 4341223 TI - [Radioclinical considerations of giant-cell tumors of the bone]. PMID- 4341224 TI - [Diagnosis and therapy of the eosinophilic bone granuloma]. PMID- 4341225 TI - [Position of angiography in the diagnosis of bone neoplasms]. PMID- 4341226 TI - [Results of tomography of the orbit]. PMID- 4341227 TI - [Radiodiagnosis and clinical aspects of the malignant synovialioma. Studies on 31 patients]. PMID- 4341228 TI - [Differential diagnostic aspects in radiodiagnosis of specific spondylitis and of bone neoplasm of the spinal column]. PMID- 4341229 TI - [Value of "improved" radiographs for the recognition of bone metastases as compared with scintigraphy]. PMID- 4341230 TI - [Studies on rib neoplasms]. PMID- 4341231 TI - [Megavolt therapy of malignant bone diseases with special reference to fractionation with high single doses]. PMID- 4341232 TI - [Combined cytostatic and radiation treatment of advanced skeleton and skin manifestations in lymphogranulomatosis]. PMID- 4341234 TI - [Radiostrontium scintigraphy in plasmacytoma]. PMID- 4341233 TI - [Clinical results of combination therapy with 32 Phosphorus and anabolics agents in multiple bone metastasis]. PMID- 4341235 TI - [Scintigraphic results in malignant bone neoplasms]. PMID- 4341236 TI - [Short-lived radionucleides in the diagnosis of bone neoplasms]. PMID- 4341237 TI - [Kinetics of calcium metabolism in malignant bone neoplasms]. PMID- 4341239 TI - [New methods for early diagnosis of osteoporosis]. PMID- 4341238 TI - [Tin--a new radioisotope for bone scintigraphy]. PMID- 4341240 TI - [New procedures in the pharmacology of triiodinated angiographic contrast media]. PMID- 4341241 TI - [Clinical test of a new water-soluble contrast medium for lumbosacral myelography]. PMID- 4341242 TI - [Therapy of anaphylactic shock using high doses of corticoids]. PMID- 4341243 TI - [Pathology of radiation effects in intact nerve tissue and in central nervous system neoplasms]. PMID- 4341244 TI - [Pathogenesis of late radiation-induced necrosis by means of experimental and human pathological studies]. PMID- 4341246 TI - [Symptom limitation: surgical treatment or radiotherapy]. PMID- 4341247 TI - [Limitations and possibilities in radiotherapy]. PMID- 4341245 TI - [Radiation-induced alterations of brain tissue following radiotherapy of intracranial neoplasms]. PMID- 4341248 TI - [Late radiation-induced necrosis of the spinal cord with paraplegia--a misevaluation?]. PMID- 4341249 TI - [Planning of radiotherapy and evaluation of therapeutic effectiveness in brain neoplasms]. PMID- 4341250 TI - [Results of radiotherapy in glioblastoma]. PMID- 4341252 TI - [Radiotherapy of medulloblastomas]. PMID- 4341253 TI - [Results of radiotherapy of brain neoplasms]. PMID- 4341251 TI - [Radiotherapy of ependymoma]. PMID- 4341254 TI - [Standardization of radiotherapy of neoplasms located near to the base of the skull]. PMID- 4341255 TI - [Electronic data processing in radiology]. PMID- 4341256 TI - [A rational system for automatic data processing]. PMID- 4341257 TI - [Electronic data processing in radiodiagnosis]. PMID- 4341258 TI - [Principles of mechanical documentation of findings in radiodiagnosis]. PMID- 4341259 TI - [Documentation in the diagnosis of stomach and gallbladder diseases]. PMID- 4341261 TI - [Abbreviated key for radiodiagnosis]. PMID- 4341260 TI - [Computer compatible list of characteristics for the condition of the urinary organs]. PMID- 4341262 TI - [Planning and preparations for supplying the documentation of radiological systems with electronic data processing]. PMID- 4341263 TI - [Current status of technology for radiological data processing]. PMID- 4341264 TI - [Pathogenesis and pathological anatomy of acquired heart valve defects]. PMID- 4341265 TI - [Radiological aspects of acquired heart valve defects]. PMID- 4341266 TI - [Uses of occupational therapy in hand injuries]. PMID- 4341268 TI - Glomus tumors of the hand: review of the literature and report on twenty-eight cases. PMID- 4341267 TI - Prophylactic use of topical antibiotic irrigation in uninfected surgical wounds. A microbiological evaluation. PMID- 4341269 TI - Epitheiloid sarcoma: two case reports. PMID- 4341271 TI - The effects of aggregated immunoglobulins on human blood platelets in relation to their complement-fixing abilities. II. Structural requirements of the immunoglobulin. PMID- 4341270 TI - The role of immunological tests in routine synovial fluid analysis. PMID- 4341273 TI - Hypersensitivity to ascaris antigens. VII. Isolation and partial characterization of an allergen. PMID- 4341272 TI - Use of the 51 Cr release test to demonstrate patterns of antibody response in humans to herpesvirus types 1 and 2. PMID- 4341274 TI - Vitamin B 12 and methionine metabolism in the Buffalo rat liver and Morris 5123 hepatoma. PMID- 4341276 TI - Synchronization of augmented luteinizing hormone secretion with sleep during puberty. PMID- 4341275 TI - Isolated hypoaldosteronism in adults. A renin-deficiency syndrome. PMID- 4341277 TI - Recurrent oral ulcers. PMID- 4341278 TI - [Repeated sequences of DNA in eukaryotes--analysis of reassociation kinetics by so-called "cot curve"]. PMID- 4341280 TI - Inborn errors of lipid metabolism. XXVI. Two sub-fractions of pre-beta lipoproteins. PMID- 4341279 TI - [Spin label method--with special reference to the study on the cell membrane]. PMID- 4341281 TI - [Laboratory verifications of leptospirosis]. PMID- 4341282 TI - [Anatomoclinical study of a case of severe leptospirosis]. PMID- 4341283 TI - [Value of immunofluorescence in severe bullous dermatitis]. PMID- 4341284 TI - [Larva migans visceralis. Diagnosis by laparoscopy]. PMID- 4341285 TI - [Early mobilization in myocardial infarct]. PMID- 4341287 TI - [Urinary cortisol excretion in chronic hepatitis]. PMID- 4341288 TI - [Theoretical basis and experimental study of the bonding of dental ceramics and plastics by means of silanes]. PMID- 4341286 TI - [Clinical studies of primary hepatic carcinoma]. PMID- 4341289 TI - [Use of silanized mineral surfaces in the preparation of fixed dentures]. PMID- 4341291 TI - Extracranial metastasis of intracranial tumor--review of literatures and report of a case. PMID- 4341290 TI - Change of lipoprotein pattern by clofibrate in hyperglyceridaemia and mixed hyperlipidaemia. PMID- 4341293 TI - A study on the correlation between function and ultrastructure in the rat adrenal cortex. PMID- 4341292 TI - The electrophoretic changes of mammalian cells associated with malignant transformation. PMID- 4341295 TI - Effects of acidosis and alkalosis on 3',5'-GMP and 3',5'-AMP in renal cortex. PMID- 4341294 TI - Effect of running to exhaustion on skeletal muscle mitochondria: a biochemical study. PMID- 4341296 TI - Mitochondrial alterations in heart, liver, and kidney of altitude-acclimated rats. PMID- 4341297 TI - Heterogeneity of 3',5'-phosphodiesterase of gastric mucosa. PMID- 4341298 TI - [Specific antigenic extracts from Entamoeba histolytica. 2. Separation and analysis of specific fractions of the crude antigen extract]. PMID- 4341299 TI - Interaction of herpes simplex virus and rhinovirus in cell culture. Brief report. PMID- 4341300 TI - RNA polymerase complexes from mengovirus infected cells. PMID- 4341301 TI - Electron microscpic studies on replicating form of defective SV40 virus DNA. PMID- 4341302 TI - Thymidine-, uridine- and choline-kinase in rabbit kidney cells infected with herpesvirus hominis, type I and II. PMID- 4341303 TI - [Localization by immunoperoxidase of cytomegalovirus antigens in human fibroblast cell cultures. Light and electron microscopy]. PMID- 4341304 TI - Experimental foot-and-mouth disease in sheep and goats: an epizootiological model. PMID- 4341305 TI - Caffeine, calcium, and Eaton-Lambert syndrome. PMID- 4341306 TI - Sporadic juvenile amyotrophic lateral sclerosis. A clinicopathological study of a case with neuronal cytoplasmic inclusions containing RNA. PMID- 4341307 TI - Pseudomyotonia in cervical root lesions with myelopathy. A sign of the misdirection of regenerating nerve. PMID- 4341308 TI - Applicability of a microbiological technique to selection of HCR-mutants of mammalian cells. PMID- 4341309 TI - Abortive infection of LLC-MK2 cells by Herpes simplex virus. PMID- 4341310 TI - [Herpesvirus infection in Hodgkin's disease]. PMID- 4341311 TI - Intestinal absorption of vitamin D 3 in epileptic patients and phenobarbital treated rats. PMID- 4341312 TI - An experimental investigation on the mechanisms of interaction of asymmetrical acute epileptic foci. PMID- 4341314 TI - [Clinical and morphological studies of insulinoma]. PMID- 4341313 TI - RNA fractionation on Kieselguhr columns. PMID- 4341315 TI - Definition and use of renin reaction velocity in the study of human hypertension. PMID- 4341316 TI - [Reaction of naphthylamine with Marquis reagent]. PMID- 4341317 TI - Mechanism of negative temperature coefficient of nerve blocking action of allethrin. PMID- 4341318 TI - Spin immunoassay of opiate narcotics in urine and saliva. PMID- 4341319 TI - [Comparative study of immunobiological reactions under the effect of ACTH and prednisolone]. PMID- 4341320 TI - Drug therapy. Treatment of common parasitic infections of man encountered in the United States. 2. PMID- 4341321 TI - [Mechanism of hypervasopressinism in hypopituitary dwarfism. Research on the role of thyroid insufficiency]. PMID- 4341322 TI - [Osteoporosis]. PMID- 4341323 TI - Diagnostic features of colloid adenocarcinoma of anal ducts and colitis cystica profunda. PMID- 4341325 TI - Care of the burn wound with topical Neosporin. PMID- 4341324 TI - Studies of human growth hormone. PMID- 4341326 TI - Treatment of metastasis of Wilms' tumor. PMID- 4341327 TI - Management of vascular tumors of the head and neck. PMID- 4341328 TI - Carcinoma of lung metastatic to the testis. PMID- 4341329 TI - [Ganglioneuroma of the hypoglossal nerve]. PMID- 4341330 TI - Ectasia of cerebral arteries in acromegaly. PMID- 4341331 TI - Isolation of the cholinergic receptor protein of Torpedo electric tissue. PMID- 4341332 TI - Glutamic acid and primary afferent transmission. PMID- 4341333 TI - An approach to the study of the biochemical pharmacology of cholinergic function. PMID- 4341335 TI - Application of microchemical analysis and subcellular fractionation techniques to the study of neurotransmitters in discrete areas of mammalian brain. PMID- 4341334 TI - Hypophysectomy and rat brain metabolism: effects of synthetic ACTH analogs. PMID- 4341336 TI - Disposition and role of newly synthesized amines in central catecholaminergic neurons. PMID- 4341337 TI - The pathogenesis of hypertension in end-stage renal disease: the role of the renin- angiotensin system. PMID- 4341339 TI - The skin pressure time integral and number of impulses in sensory skin nerve fibres of the cat. PMID- 4341338 TI - Hypertension in patients on maintenance hemodialysis: evaluation of peripheral renin activity and bilateral nephrectomy. PMID- 4341340 TI - Growth of transplantable chrysoidine hepatoma after splenectomy in mice. PMID- 4341341 TI - The activity of some enzymes of carbohydrate metabolism in chrysoidine hepatoma of mice and Kirkman-Robbins hepatoma of hamsters. PMID- 4341342 TI - Role of lipolytic and glucocorticoid hormones in the development of diabetic ketosis. PMID- 4341343 TI - An overview of intestinal absorptive and secretory processes. PMID- 4341345 TI - Studies on calciferol metabolism. IV. Subcellular localization of 1,25-dihydroxy vitamin D 3 in intestinal mucosa and correlation with increased calcium transport. PMID- 4341344 TI - Highly purified synaptosomal membranes from rat brain. Preparation and characterization. PMID- 4341347 TI - Putrescine oxidase from Micrococcus rubens. Purification and properties of the enzyme. PMID- 4341346 TI - Rachitogenic activity of dietary strontium. I. Inhibition of intestinal calcium absorption and 1,25-dihydroxycholecalciferol synthesis. PMID- 4341348 TI - The purification and biochemical characterization of bovine liver nuclear membranes. PMID- 4341349 TI - Characterization of electron transport activity in bovine liver nuclear membranes. PMID- 4341350 TI - Adenosine 3',5-monophosphate-dependent phosphorylation of a specific protein in synaptic membrane fractions from rat cerebrum. PMID- 4341351 TI - The role of oxidized nicotinamide adenine dinucleotide in fluoride inhibition of active sodium transport in human erythrocytes. AB - The rate coefficient for (22)Na release from previously labeled human erythrocytes was determined in the presence of 0.1-10 mM sodium fluoride (F). The oxidized nicotinamide adenine dinucleotide (NAD(+)) level at the end of 2 hr of incubation in tris(hydroxymethyl)aminomethane (Tris)-Ringer medium was also measured. Both parameters decreased proportionately as F concentration was raised. Both F-induced changes were immediate and were reversed by 10 mM pyruvate. The decrease in NAD(+) concentration following enolase inhibition by F is attributed to a diminished rate of formation in the reaction catalyzed by lactic dehydrogenase (LDH) with undiminished continued utilization in the reaction catalyzed by glyceraldehyde-3-phosphate dehydrogenase (GAPDH). It is postulated that the NAD(+) lowering limited the GAPDH step, resulting in proportionate decreases in the rates of phosphoglycerate kinase (PGK) and Na,K dependent adenosine triphosphatase (Na,K-ATPase), a reaction sequence thought to link glycolysis with active Na extrusion. Adding pyruvate with F increased NAD(+) production at the LDH step, thus reactivating GAPDH, PGK, and Na,K-ATPase and leading to the observed restoration of (22)Na release. The results suggest, therefore, that F inhibits active Na transport in intact human erythrocytes indirectly through a lowering of NAD(+), although, direct inhibition of the Na,K ATPase by F may possibly occur simultaneously. PMID- 4341352 TI - Neurosecretory cells in the cerebral ganglion of adult tunicates: fine structure and distribution of phosphatases. PMID- 4341353 TI - Collagen diseases, hepatitis-associated antigen, and the Epstein-Barr virus. PMID- 4341354 TI - Effect of ultraviolet light and a potent carcinogen, 4-nitroquinoline 1-oxide, on mammalian cells and their Sendai virus carrier cultures. PMID- 4341355 TI - [Results of current experimental research of sleeping and dreaming]. PMID- 4341357 TI - [Relationship between caffeine and intermediate metabolism]. PMID- 4341356 TI - Uptake of blood triglyceride by various tissues. PMID- 4341358 TI - [Coffee in the diet of the sportsman]. PMID- 4341359 TI - [Effect of coffee on deposit lipids]. PMID- 4341360 TI - [Current results of the treatment of pseudoparalytic myasthenia gravis with immunosuppressive agents]. PMID- 4341361 TI - On malignant transformation in fibrous dysplasia of bone. PMID- 4341362 TI - Oral contraceptive hypertension. PMID- 4341363 TI - Adenosine 3',5'-monophosphate and N 6 -2'-O-dibutyryl-adenosine 3',5' monophosphate transport in cells. AB - Incubation of Strain L cells in 0.15 millimolar adenosine 3',5'-monophosphate (cyclic AMP) increase the intracellular level of cyclic AMP more than does incubation in dibutyryl cyclic AMP. The intracellular increase of cyclic AMP is greater with Strain L than with WI-38 cells. Similarly, cell division of Strain L cells is inhibited more by cyclic AMP. The experiments do not, support the belief that dibutyryl cyclic AMP is transported better than cyclic AMP. PMID- 4341364 TI - Umbilical portography using lipiodol. PMID- 4341365 TI - Growth of a fibrous duct around a teflon fistula after common duct injury. PMID- 4341366 TI - Studies on an extra pre-beta lipoprotein fraction. PMID- 4341369 TI - Studies of the distribution of cochlear potentials along the basilar membrane. PMID- 4341368 TI - The response of murine nerve tissue culture to murine cytomegalic virus. PMID- 4341367 TI - [Morphology of transplacentally induced neurogenic tumors in Syrian hamsters]. PMID- 4341370 TI - The assay of potassium 6-(L-(+)- -phenoxypropionamido)penicillanate and 6-(D-(+)- -phenoxypropionamido)penicillanate in phenethicillin potassium by circular dichroism spectrometry. PMID- 4341371 TI - Determination of alphachloralose. I. In stupefying bait. PMID- 4341372 TI - [Dwarfism caused by sporadic and idiopathic pituitary insufficiency. Study of a series of 31 cases]. PMID- 4341373 TI - Pleural origin of some of the supposed chemodectoid structures of the lung. PMID- 4341374 TI - Increased protein synthesis of spleen cells after injection of Bordetella pertussis into mice. PMID- 4341375 TI - Reactions of tetranitromethane. Mechanism of the reaction of tetranitromethane with pseudo acids. PMID- 4341376 TI - Studies of the composition and structure of plasma lipoproteins. Separation and quantification of the lipoprotein families occurring in the high density lipoproteins of human plasma. PMID- 4341377 TI - Adrenocorticotropin. Synthesis of (6-phenylalanine)- 1-19 -adrenocorticotropic hormone and its steroidogenic, melanocyte-stimulating, and lipolytic activity. PMID- 4341378 TI - Molecular weight and subunit structure of hagfish transferrin. PMID- 4341379 TI - "Increased-valence" formulas for the iron-ligand bonding of some ferrohaemoglobin compounds. PMID- 4341380 TI - The hydrolysis of poly (L-Prolyl-Glycyl-L-Prolyl) by bacterial collagenase. PMID- 4341381 TI - [Value of lympho-angio-adenography in establishing the degree of development of rectocolic cancer]. PMID- 4341382 TI - Rapid quantitative gas-chromatographic fractionation of the major urinary 17 oxosteroids and 17-oxogenic steroids. PMID- 4341383 TI - [Formation of anti-ACTH antibody]. PMID- 4341384 TI - [Effect of fetal adrenal stimulation and supression on estrogen concentration in the umbilical cord blood and maternal peripheral blood]. PMID- 4341385 TI - Spectrophotometric and fluorometric studies on the mechanism of chemoreception in the carotid body. PMID- 4341386 TI - Oxidative metabolism at low PO 2 . PMID- 4341387 TI - Occurrence of macrozamin in the seeds of Encephalartos hildebrandtii. PMID- 4341388 TI - Carcinogenicity of azoxymethane dependent on age in BD rats. PMID- 4341389 TI - Methylazoxymethanol acetate: induction of tumors and early effects of RNA synthesis. PMID- 4341390 TI - Carcinogenicity and neurotoxicity of cycasin with sepcial reference to species differences. PMID- 4341391 TI - Lipid composition of the cerebellum and spinal cord in postnatal cycasin-treated Swiss albino mice: preliminary observations. PMID- 4341392 TI - Rem sleep, depression, and nocturnal migraine. PMID- 4341393 TI - Effectiveness of filter caging in the prevention of viral diseases of cats. PMID- 4341394 TI - Pox in young, captive harbor seals. PMID- 4341395 TI - Parainfluenza-3 virus infection in Rocky Mountain bighorn sheep. PMID- 4341396 TI - Chickenpox in young anthropoid apes: clinical and laboratory findings. PMID- 4341397 TI - Endocrine responses of stress susceptible and stress resistant swine to environmental stressors. PMID- 4341398 TI - Isolation of renin granules from the dog kidney cortex. PMID- 4341399 TI - The effect of stimulus interval on the auditory evoked response during sleep in autistic children. PMID- 4341400 TI - Liquid scintillation measurement of radioactivity in hard tissue abrasion slurries. PMID- 4341401 TI - Hepatitis-associated antigen and antibody in hepatocellular carcinoma: results of a continuing study. PMID- 4341402 TI - Nature of virus-producing Rous sarcoma cells in hamsters treated with antilymphocyte serum: immunochemical, cytogenetical, and electron microsopic observations. PMID- 4341403 TI - Nitrosamine studies: neoplasms of liver and genital mesothelium in nitrosopyrrolidine-treated MRC rats. PMID- 4341405 TI - Tumor-specific vaccine containing Mycobacterium bovis and tumor cells: safety and efficacy. PMID- 4341404 TI - Histopathology of tumor regression after intralesional injection of Mycobacterium bovis., 2. Comparative effects of vaccinia virus, oxazolone, and turpentine. PMID- 4341406 TI - Basis for the serine requirement in leukemic and normal human leukocytes. Reduced levels of the enzymes in the phosphorylated pathway. PMID- 4341407 TI - [Influence of oxyphenbutazone on the propagation of poliomyelitis virus and herpes simplex virus in tissue cultures]. PMID- 4341408 TI - [The neuromuscular spindle]. PMID- 4341409 TI - EB virus and infectious mononucleosis. PMID- 4341410 TI - [Experimental diabetic retinopathy in the rat]. PMID- 4341411 TI - Photocoagulation of diabetic maculopathy. PMID- 4341412 TI - [Medroxyprogesterone acetate in the treatment of idiopathic precocious puberty]. PMID- 4341413 TI - [Influence of initial stretch on the dynamics of vascular smooth muscle]. PMID- 4341414 TI - [Problems posed by pulmonary aspergillosis]. PMID- 4341415 TI - [Action of bufotenin on synaptic transmission in the sympathetic vegetative ganglia]. PMID- 4341416 TI - The mental tonic effect of oestrogens administered to oophorectomized females. PMID- 4341417 TI - Cysts and neoplasms in the infant lung. PMID- 4341418 TI - [Karyokinesis and nuclear morphology during hepatocarcinogenesis. I. Mitoses and mitotic abnormalities in hepatocytes and hepatoma cells of the nitrosomorpholine intoxicated rat liver]. PMID- 4341419 TI - Comparative studies on the effects of aminoglutethimide, metopirone, ACTH and hydrocortisone on the adrenal cortex of adult male rats. I. Karyometric studies. PMID- 4341420 TI - [Plasma-11-hydroxycorticosteroid determinations following intramuscular glucagon administration]. PMID- 4341421 TI - [Influence of PVA-gel incubation on the topochemical demonstration of soluble NAD dependent lactate dehydrogenase]. PMID- 4341422 TI - Hepatocellular carcinoma. Clinical and laboratory observations. PMID- 4341423 TI - [Possibilities for the use of a gas-mass-spectrometer (varian MAT M3) in anaesthesia]. PMID- 4341424 TI - [Lipid balance in retinal vasculopathies]. PMID- 4341425 TI - Enhanced uptake of calcium by transforming lymphocytes. PMID- 4341426 TI - Carcinoma of the lung and anthracosilicosis. PMID- 4341427 TI - Primary tumors of the mediastinum. PMID- 4341428 TI - [Improved method of orthophosphate determination]. PMID- 4341429 TI - The indirect confirmation of hyperlipoproteinemia phenotypes II, 3 and IV. PMID- 4341430 TI - Urinary androgens under stimulation-suppression tests in children with gonadal dysgenesis. PMID- 4341431 TI - Acyl phosphatase in normal and diseased human muscle. PMID- 4341432 TI - Effect of neuraminic acid removal on the properties of a variant alkaline phosphatase in hepatoma. PMID- 4341434 TI - A rapid ultraviolet spectrophotometric lactic dehydrogenase assay. PMID- 4341433 TI - Studies on a variant alkaline phosphatase in sera of patients with hepatocellular carcinoma. PMID- 4341435 TI - Studies on the protein defect in Tangier disease. Isolation and characterization of an abnormal high density lipoprotein. AB - High density lipoproteins (d 1.063-1.210 g/ml) were isolated from the plasma of normal individuals (HDL) and seven homozygous patients with Tangier disease (HDLt). In Tangier patients, the concentration of protein in the high density region (HDLt) was only 0.5-4.5% of normal. Immunochemical studies, including mixing experiments conducted in vivo and in vitro, indicated that HDLt was different from HDL. HDLt was the only high density lipoprotein detectable in the plasma of Tangier homozygotes. In heterozygotes both HDL and HDLt were present. HDLt was not detected in the plasma of over 300 normal persons and 10 patients with secondary high density lipoprotein deficiency and appeared to be a unique marker for Tangier disease.ApoHDL contained two major apoproteins designated apoLp-Gln-I and apoLp-Gln-II; together they comprised 85-90% of the total protein content. Both of the major HDL apoproteins were present in apoHDLt; but apoLp-Gln I was disproportionately decreased with respect to apoLp-Gln-II, the ratio of their concentrations being 1: 12 in apoHDLt as compared with 3: 1 in apoHDL. Several minor apoprotein components which together comprise 5-15% of apoHDL were present in approximately normal proportions in apoHDLt. In the HDL of Tangier patients it was estimated that, compared with normal individuals, the concentration of apoLp-Gln-I was decreased about 600-fold and the concentration of apoLp-Gln-II about 17-fold. The decrease in these apoproteins was not due to preferential segregation with the lipoprotein fractions of d < 1.063 g/ml or with the plasma proteins of d > 1.21 g/ml. Tangier apoLp-Gln-I and apoLp-Gln-II appeared to be immunochemically identical with their normal counterparts, and no differences between the two sets of apoproteins were detected on polyacrylamide gel electrophoresis at pH 9.4 or 2.9. These results are most compatible with the hypothesis that the hereditary defect in Tangier disease is a mutation in an allele-regulating synthesis of apoLp-Gln-I. PMID- 4341436 TI - Studies on human platelet gangliosides. AB - Gangliosides, glycosphingolipids which contain sialic acid, were studied in human platelets. They represented 0.5% of the platelet lipids and accounted for 6% of the total neuraminic acid content of platelets. Three major ganglioside fractions were identified and characterized. Ganglioside I was hematoside (G(6)) and comprised 92% of the platelet gangliosides. It contained glucose, galactose, and sialic acid in molar ratios of 1:1:1 and no hexosamine. The major fatty acid was behenate (22:0). Ganglioside I was also identified in isolated platelet granules and membranes. Ganglioside II (5%) contained glucose, galactose, sialic acid, and hexosamines (molar ratios 1:2:1:1). The hexosamines were glucosamine (72%) and galactosamine (28%). It was therefore designated as ganglioside lacto-N neotetraose. Ganglioside III (2%) contained disialosyllactosyl ceramide (G(3A)) as well as two other gangliosides which could not be precisely characterized. Gangliosides I, II, and III were susceptible to the action of Clostridium perfringens neuraminidase as evidenced by full recovery of sialic acid in its free form after incubation. Neutral platelet glycolipids were qualitatively examined by thin-layer chromatography. The major component was lactosyl ceramide. Interactions of gangliosides I and III and serotonin-(14)C were examined in an equilibrium dialysis system at 4 degrees C. The gangliosides bound serotonin (14)C in relatively small quantities, whereas control lipids were negative. The binding was essentially unchanged by reverse dialysis, ultracentrifugation and subsequent thin-layer chromatography. The results are comparable to the previously observed nonmetabolic interactions between whole platelets and serotonin in the cold. It is suggested that the orientation and specific distribution of platelet membrane glycolipids may be important determinants of the unique surface properties of platelets. PMID- 4341437 TI - The transport of exogenous cholesterol in the rabbit. I. Role of cholesterol ester of lymph chylomicra and lymph very low density lipoproteins in absorption. AB - Thoracic lymph duct cannulations were performed shortly after a meal in rabbits trained to ingest a moderate fat, low cholesterol diet. A tracer dose of cholesterol-(3)H was administered to label exogenous (dietary) cholesterol during absorption. Sequential lymph samples were collected up to 24 hr postprandially, after which ultracentrifugal fractionation of lymph lipoproteins was carried out. The d < 1.006 lipoproteins were separated into two classes, chylomicra and very low density lipoproteins (VLDL).A comparison was made between chylomicra and VLDL of lymph in the transport of exogenous cholesterol after ingestion of a single meal. The per cent of exogenous cholesterol present in VLDL of sequential lymph collections progressively increased with time after a meal and by 18 hr had reached a value of 80% or greater. In chylomicra the per cent of exogenous cholesterol of sequential lymph collections progressively decreased. Therefore, exogenous cholesterol was preferentially transported in VLDL compared with chylomicra. Cholesterol ester specific activity (CESA) of lymph chylomicra and VLDL increased at a more rapid rate than free cholesterol specific activity (FCSA). CESA of VLDL was three times higher than FCSA at the maximum. Exogenous cholesterol which appeared in both chylomicra and VLDL was consistently 80% esterified. while the per cent of total cholesterol esterified decreased with time and was significantly lower than that for exogenous cholesterol from 6 to 24 hr postprandially. These results demonstrate preferential esterification of exogenous cholesterol during absorption and indicate that a mechanism exists within the intestinal mucosal cell to maintain both free and esterified exogenous cholesterol in a chemically distinct pool from endogenous cholesterol during incorporation into both chylomicra and VLDL. PMID- 4341438 TI - Critical role of the carbohydrate side chains of collagen in platelet aggregation. AB - The reaction between human platelet membrane glucosyl transferase and collagen has recently been proposed as the mechanism for pletelet-collagen adhesion. Collagen contains glucosyl-galactose and galactose side chains linked through the galactose to hydroxylysine. Oxidation of the 6-hydroxymethyl position of the galactosyl residue to aldehydes with galactose oxidase completely abolishes platelet aggregation. This enzymatic modification of collagen can be fully reversed by reduction of the aldehydes formed by NaBH(4) with complete restoration of platelet aggregating ability. Limited digestion with bacterial collagenase abolishes the ability of collagen to aggregate platelets. Removal of the N-terminal telopeptides from collagen with trypsin does not affect platelet aggregation. Tertiary structure of soluble collagen is essential for platelet aggregation. Normal collagen is less effective than lathyritic collagen, which contains only a small number of cross-links. The decreased number of aldehyde groups in the lathyritic collagen are not responsible for the increase in aggregating ability, since reduction with NaBH(4) does not alter platelet aggregation. These results suggest that integrity and accessibility of the galactose receptor site may be crucial for the formation of a ternary collagenenzyme-platelet membrane complex which must precede platelet aggregation. PMID- 4341439 TI - An effect of dexamethasone on adenosine 3',5'-monophosphate content and adenosine 3',5'-monophosphate phosphodiesterase activity of cultured hepatoma cells. AB - The effect of dexamethasone on adenosine 3',5'-monophosphate (cAMP) phosphodiesterase activity in cultured HTC hepatoma cells was investigated. Homogenates of these cells contain phosphodiesterase activity with two apparent Michaelis constants for cAMP (2-5 mum and 50 mum). At all substrate concentrations tested, phosphodiesterase activity was decreased 25-40% in cells incubated for 36 hr or more with 1 mum dexamethasone. Acid phosphatase activity in the same cells was not decreased. alpha-Methyl testosterone, 1 mum, was without effect on phosphodiesterase activity. Incubation for 10 min with epinephrine plus theophylline increased the cAMP content of the HTC cells 3- to 6 fold. In cells incubated for 72 hr with dexamethasone, the basal concentration of cAMP was slightly increased and the increment produced by epinephrine plus theophylline was markedly increased. We believe that in many cells the so-called permissive effects of steroid hormones on cAMP mediated processes may be due to an effect of these hormones on cAMP phosphodiesterase activity similar to that observed in HTC cells incubated with dexamethasone. PMID- 4341442 TI - Severe reaction from tetracosactrin. PMID- 4341440 TI - A classification of the murine leukemia viruses. Neutralization of pseudotypes of Friend spleen focus-forming virus by type-specific murine antisera. AB - Coinfection of neonatal BALB/c mice with helper-dependent Friend spleen focus forming virus (SFFV), as contained in the Friend virus (FV) complex, and antigenically distinct Moloney leukemia virus (MolLV) resulted in the recovery of a MolLV pseudotype of SFFV, abbreviated SFFV(MolLV). The antigenic alteration of SFFV was observed by following its neutralization kinetics in vitro by specific Friend or Moloney typing antiserum. Effective pseudotype production was accomplished only when N-tropic LLV-F (the natural helper virus in the FV complex) was inhibited in B-type mice coinfected with an NB-tropic MolLV or other murine leukemia virus (MuLV) preparation. SFFV pseudotypes could not be prepared by using murine viruses other than leukemia viruses. SFFV prepared after two serial passages in the presence of MolLV was effectively neutralized by Moloney antiserum, but not by Friend typing antiserum; therefore, the envelope of the pseudotype virus, SFFV(MolLV), is homogeneous. Pseudotype virus was antigenically stable in the absence of continued mixed infection of BALB/c mice with SFFV(MolLV) and MolLV. However, SFFV(MolLV) was easily converted back to the LLV F type after only one passage in BALB/c mice coinfected with NB-tropic LLV-F. The antigenic interconversion between LLV-F and MolLV types demonstrated that SFFV is defective with respect to the expression of neutralizable envelope antigens. Analysis of the neutralizable envelope antigens of nine SFFV(MuLV) pseudotypes by a panel of seven typing antisera made possible a "type-specific" SFFV(MuLV) envelope classification. Two major categories have been identified which correspond to the Gross (G) and Friend-Moloney-Rauscher (FMR) subgroups. Further, the FMR subgroup was divided into four types on the basis of distinct neutralization patterns. These results indicated that the specificity observed by cytotoxic G vs. FMR antisera is different from that observed by neutralization kinetics. We therefore suggest that the specific antigens revealed by virus neutralization tests be referred to as type specific. PMID- 4341441 TI - Pancreatic visualization with 75 Se-selenomethionine after surgery. PMID- 4341443 TI - Demonstration of cytomegalovirus in semen. PMID- 4341444 TI - Description of anomalous E.S.R. signals from normal rabbit liver. PMID- 4341445 TI - Ontogeny of memory. PMID- 4341446 TI - Electron paramagnetic resonance study of irradiated tooth enamel. PMID- 4341447 TI - [Relationship between bone age, functional anthropometric data and aerobic capacity]. PMID- 4341448 TI - [Treatment of herpetic diseases of the skin with interferon and inductors of its formation]. PMID- 4341449 TI - Mechanisms of azo reduction by Streptococcus faecalis. II. The role of soluble flavins. PMID- 4341451 TI - Quantitative determination of dehydrogenase activity in tissue sections and tissue homogenates. PMID- 4341450 TI - Enzyme studies in man with extra-hepatic biliary obstruction. PMID- 4341452 TI - [Influencing of the enzyme activity of collagenase by antibodies]. PMID- 4341453 TI - Diphtherial myocardiopathy. PMID- 4341455 TI - Malignant nonchromaffin paraganglioma of the stomach. PMID- 4341454 TI - "Ketotic hypoglycemia" due to hepatic fructose-1,6-diphosphatase deficiency: treatment with folic acid. PMID- 4341456 TI - The association of viral and mycoplasma infections with recurrence of wheezing in the asthmatic child. PMID- 4341458 TI - Chloramphenicol-induced vacuoles. Their ultrastructure in bone marrow pronormoblasts and immature myeloid cells. PMID- 4341457 TI - Histochemical localization of enzymes in cartilage in neonatal and adult rats. PMID- 4341460 TI - Effects of excitatory and inhibitory synaptic actions on RNA content of spinal motoneurones. PMID- 4341459 TI - The effect of membrane parameters on the properties of the nerve impulse. AB - The effect of varying membrane capacitance, conductance, and rate constants on the properties of the nerve impulse is considered in terms of the degree of regeneration in the Hodgkin-Huxley model for the squid giant axon. It is shown through computer simulation that reducing regeneration generally increases the duration of the action potential and decreases its amplitude, rate of rise, and conduction velocity. The threshold becomes much less sharp and the amplitude of the response of a patch of membrane grades with stimulus strength. A second stimulus, applied shortly after a first stimulus, considerably perturbs the membrane potential from its original time-course. Under certain conditions, the nerve signal can propagate with a small decrement. PMID- 4341461 TI - Analysis of neural unit-data: effect of threshold upon average response frequency. PMID- 4341462 TI - Depolarization of dorsal root ganglia in the cat by GABA and related amino acids: antagonism by picrotoxin and bicuculline. PMID- 4341463 TI - Inhibition of creatine phosphokinase activity and synaptic transmission by black widow spider venom. PMID- 4341464 TI - Vitamin C and the common cold. PMID- 4341465 TI - Diabetes mellitus: current concepts of the hormonal and metabolic defects. AB - In the last 50 years our conception of diabetes has changed considerably. It is no longer just a failure of the pancreas to release insulin. It may be a resistance to insulin, so that amounts which would ordinarily be normal are no longer adequate for the body. The relative deficiency of insulin may also represent the release of what would otherwise be normal amounts of insulin at the wrong time. Indeed diabetes may not only be insulin deficiency, but also glucagon excess. The consequences of this complex hormonal imbalance are not simply failure to metabolize glucose, but also excessive production of glucose and alteration of the body's capacity to handle the other nutrients - amino acids and fatty acids. Not only may these two hormones, insulin and glucagon, regulate the metabolism of more than glucose alone but they are, in turn, regulated by more than glucose. Furthermore, one consequence of inability to burn glucose along normal pathways may be that it is converted to substances such as sorbitol and glycoproteins and this conversion may give rise to many of the complications of diabetes. PMID- 4341466 TI - Excitation-contraction coupling of isolated cardiac fibers with disrupted or closed sarcolemmas. Calcium-dependent cyclic and tonic contractions. PMID- 4341467 TI - Incorporation of the terminal phosphate of ATP into membranal protein of rabbit cardiac sarcoplasmic reticulum. Correlation with active calcium transport and study of the effects of cyclic AMP. PMID- 4341468 TI - Mechanisms regulating renin release in dogs with thoracic caval constriction. PMID- 4341469 TI - Mechanism of enhancement by angiotensin II of sympathetic adrenergic transmission in the guinea pig. PMID- 4341470 TI - Purification and properties of angiotensin-converting enzyme from hog lung. PMID- 4341471 TI - Radioimmunoassay and clearance of circulating dopamine- -hydroxylase. PMID- 4341472 TI - Evidence that the renal pressor substance of Grollman is related to angiotensin I. PMID- 4341474 TI - Mechanism of action of angiotensin in smooth muscle cell. Biochemical changes following interaction of the hormone with its membrane receptors. PMID- 4341473 TI - Angiotensin II. Studies on the biologically active conformation. PMID- 4341475 TI - Increased fluid turnover and the activity of the renin-angiotensin system under various experimental conditions. PMID- 4341476 TI - Activation of renin in the single juxtaglomerular apparatus by sodium chloride in the tubular fluid at the macula densa. PMID- 4341477 TI - Studies on angiotensinogen formation in a liver perfusion system. PMID- 4341478 TI - Effect of prostaglandin A 1 on renal and adrenal function in man. PMID- 4341479 TI - Metabolism of angiotensin II in sodium depletion and hypertension in humans. PMID- 4341480 TI - Angiotensin I converting enzyme of the lung. PMID- 4341481 TI - Inhibition of the conversion of angiotensin I to II and potentiation of bradykinin by small peptides present in Bothrops jararaca venom. PMID- 4341482 TI - Converting enzyme and bradykininase in the lung. PMID- 4341483 TI - Aspidogaster conchicola: histochemical localization of carboxylic ester hydrolases. PMID- 4341484 TI - Cytochemical and biochemical observations on the digestive tracts of digenetic trematodes. IX. Megalodiscus temperatus. PMID- 4341485 TI - Delta 2 -isopentenylpyrophosphate: transfer ribonucleic acid 2 isopentenyltransferase from Escherichia coli. Purification and properties of the enzyme. PMID- 4341486 TI - Localization of an adrenocorticotropic hormone receptor on bovine adrenal cortical membranes. PMID- 4341487 TI - Studies on calciferol metabolism. V. The occurrence and biological activity of 1,25-dihydroxy-vitamin D 3 in bone. PMID- 4341488 TI - A common structural unit in asparagine-oligosaccharides of several glycoproteins from different sources. PMID- 4341489 TI - The effect of dibutyryl cyclic adenosine monophosphate on synthesis of sulfated acid mucopolysaccharides by transformed fibroblasts. PMID- 4341490 TI - Permeation of glucose by simple and facilitated diffusion by Novikoff rat hepatoma cells in suspension culture and its relationship to glucose metabolism. PMID- 4341491 TI - The role of putidaredoxin and P450 cam in methylene hydroxylation. PMID- 4341492 TI - A Bacillus ribonucleic acid phosphodiesterase with associated 5'-nucleotidase activity. PMID- 4341494 TI - On the subunit structure of the protein of human serum high density lipoprotein. I. A study of its major polypeptide component (Sephadex, fraction 3). PMID- 4341493 TI - Biosynthesis of acyl dihydroxyacetone phosphate in subcellular fractions of rat liver. PMID- 4341495 TI - On the subunit structure of the protein of human serum high density lipoprotein. II. A study of Sephadex fraction IV. PMID- 4341496 TI - Cleavage of replicative intermediates of simian virus 40 deoxyribonucleic acid by the restriction endonuclease of Escherichia coli B. PMID- 4341497 TI - Poly (adenosine diphosphate ribose) synthesis in soluble extracts of animal organs. PMID- 4341499 TI - Improved preparative dry-column chromatography. Analysis of resolution by puncture sampling. PMID- 4341498 TI - Biochemical studies on developing canine hip joints. PMID- 4341500 TI - Metabolic relationships among the plasma lipoproteins. Reciprocal changes in the concentrations of very low and low density lipoproteins in man. AB - The changes in other plasma lipoproteins which accompany alterations in very low density lipoproteins (VLDL) were studied in 31 normal and hyperlipidemic men and women who underwent weight reduction, carbohydrate induction, or clofibrate treatment. Plasma lipids and individual lipoprotein cholesterol concentrations were measured serially during control and treatment periods. Low density lipoprotein (LDL) protein was determined by radial immunodiffusion. Oppositely directed changes in VLDL and LDL were found with each of the three metabolic perturbations. Changes in high density lipoprotein (HDL) cholesterol generally paralleled those in LDL but were less consistent. Two patients with type III hyperlipoproteinemia failed to demonstrate reciprocal increases in LDL despite more than 40% reduction in plasma glycerides or VLDL with weight reduction or clofibrate therapy. After clofibrate therapy, LDL increased in proportion to the absolute decrease in VLDL cholesterol during treatment. LDL protein changed relatively less than did LDL cholesterol. The mechanism for the interdependency of plasma VLDL and LDL concentrations over the long term is not known and may be the result of altered rates of interconversion of these lipoproteins, or to feedback inhibition by VLDL of LDL production and release. PMID- 4341501 TI - Lithium-induced nephrogenic diabetes insipidus: in vivo and in vitro studies. AB - The physiological basis for the polyuria and polydipsia occurring in some manic depressive patients treated with lithium salts was studied in vivo and in vitro. Three lithium-treated polyuric patients, in whom other causes of a concentrating defect were excluded, had abnormal urinary concentrating abilities after a standard water depreviation test. Two of these patients failed to respond to exogenous vasopressin (ADH) and one had a subnormal response. The abilities of these patients to excrete solute-free water (C(H2O)) was comparable to normal subjects during steady-state water diuresis, suggesting no gross abnormalities in sodium transport. However, each of these patients demonstrated abnormally low capacities to reabsorb solute-free water (T(C) (H2O)) under hydropenic conditions after administration of hypertonic saline and vasopressin. These in vivo findings demonstrate at least a nephrogenic basis for the diabetes insipidus syndrome manifested by these three patients. The defect in water transport was further characterized in toad urinary bladders in vitro. Short-circuit current (I) and water flow (W) were studied under basal, ADH-stimulated, and cyclic adenosine 3',5'-monophosphate (c-AMP)-stimulated conditions. Increasing mucosal [Li(+)] progressively inhibited basal I, and both I and W induced by ADH. Significant inhibition of basal and ADH-induced I was observed at mucosal [Li(+)] < 1.1 mEq/liter, and of ADH-induced W at mucosal [Li(+)] = 11 mEq/liter. On the other hand, at these lithium concentrations, neither c-AMP-stimulated W nor I was inhibited. Increasing serosal [Li(+)] produced significant inhibition of basal I only at [Li(+)] at least 50-fold greater than at the mucosal (urinary) surface. These in vitro studies confirm that mucosal lithium inhibits the action of ADH, but not c-AMP. Hence, lithium appears to be a significant inhibitor of ADH stimulated water flow, probably acts from the urinary surface, and appears to exert its effect at a site biochemically proximal to c-AMP action. PMID- 4341503 TI - Biologic effects of 1,25-dihydroxycholecalciferol (a highly active vitamin D metabolite) in acutely uremic rats. AB - The development of a vitamin D-resistant state in the course of renal failure may be responsible for reduced intestinal absorption of calcium and an impaired response of skeletal tissue. Moreover, the kidney has been shown to carry out the conversion of 25-hydroxycholecalciferol (25-OH-CC) to a highly biologically active metabolite, 1,25-dihydroxycholecalciferol (1,25-diOH-CC). In the present studies, vitamin D-deficient rats, made acutely uremic by either bilateral nephrectomy or urethral ligation, received physiological doses of cholecalciferol (vitamin D(3)) (CC), 25-OH-CC or 1,25-diOH-CC; 24 hr later intestinal calcium transport, in vitro, and bone calcium mobilization, in vivo, were assessed. Whereas CC and 25-OH-CC stimulated calcium transport in sham-operated controls, they were without effect in the uremic animals. In contrast, administration of 1,25-diOH-CC stimulated calcium transport in both groups of uremic animals. Administration of 1,25-diOH-CC also stimulated calcium mobilization from bone in each group of animals. However, CC and 25-OH-CC were only effective in the sham controls and the uremic group produced by urethral ligation and had little or no effect in animals without kidneys. These results indicate that renal conversion of calciferol to a more biologically active form is necessary for the stimulation of intestinal calcium absorption and calcium mobilization from bone, and that 1,25-diOH-CC may bypass a possible defect in vitamin D metabolism in uremia. From these studies it is likely that uremia, per se, may also impair intestinal calcium transport. PMID- 4341502 TI - Effects of thyroid-stimulating hormone on adenyl cyclase activity and intermediary metabolism of "cold" thyroid nodules and normal human thyroid tissue. AB - "Cold" thyroid nodules do not concentrate (131)I before or after thyrotropin (TSH) administration. In an attempt to elucidate the reason for this TSH unresponsiveness, the effect of TSH in vitro on several metabolic parameters was studied in 11 "cold" thyroid adenomas, 2 medullary carcinomas, and in the surrounding normal thyroid tissue. Basal adenyl cyclase activity, glucose-1-(14)C oxidation, and (32)P incorporation into phospholipids were significantly greater in the adenomas than in the adjacent normal thyroid; basal cyclic 3',5'-adenosine monophosphate (cyclic AMP) concentration and adenine-(3)H incorporation into (3)H labeled cyclic AMP were not different. In adenomas as well as normal thyroid, all parameters responded significantly to in vitro TSH stimulation. The response to TSH of adenyl cyclase activity and (32)P incorporation was enhanced in adenomas compared with that of the adjacent normal thyroid. These differences were not explained by an increased cellularity of the adenomas. Medullary carcinomas did not respond to TSH in any of the above parameters. The studies demonstrate an intact, TSH-responsive adenyl cyclase-cyclic AMP system in the adenomas and, accordingly, imply the presence of receptor sites for TSH on the cells of the adenoma. The failure of such nodules to concentrate (131)I may be owing to a subsequent impairment in the expression of cyclic AMP action on iodine metabolism. PMID- 4341504 TI - Microvascular abnormalities in virally-induced canine brain tumors. Structural bases for altered blood-brain barrier function. PMID- 4341505 TI - Nemaline (neuro) myopathy. Rod-like bodies and type I fibre atrophy in a case of congenital hypotonia with denervation. PMID- 4341506 TI - Ultrastructural aspects of schizogony, mature schizonts, and merozoites of Haemoproteus metchnikovi. PMID- 4341507 TI - The use of crisis intervention in the rehabilitation of laryngectomees. PMID- 4341508 TI - Cardiovascular responses to bacterial endotoxin in anesthetized and nonanesthetized animals. PMID- 4341510 TI - Clara. PMID- 4341512 TI - Diagnostic improvement with angiotensin in renal angiography. PMID- 4341511 TI - Hyperglycinemia associated with hyperammonemia: in vitro glycine cleavage in liver. PMID- 4341513 TI - Tests of excitability applied to isolated tissues from the brain. PMID- 4341514 TI - The action of acetamide on the iron-laden rat liver. PMID- 4341515 TI - Liver transplantation in biliary atresia with concomitant hepatoma. PMID- 4341516 TI - [Polymyositis]. PMID- 4341517 TI - The formation of "accessory nuclei" and annulate lamellae in the oocytes of the flour moth Anagasta kuhniella. PMID- 4341518 TI - Serum lipids in prematures during the first three months of life. PMID- 4341519 TI - Hepatic ketogenesis and lipolysis. PMID- 4341520 TI - Concentration and purification of poliovirus by ultrafiltration and isopycnic centrifugation. AB - A method is described by which poliovirus can be rapidly and simply concentrated by the use of a Diaflo XM-50 ultrafilter membrane. Freon-extracted ultrafilter concentrates banded in CsCl provided a 1,724-fold volumetric concentration of poliovirus. During concentration, trypsin-digested cellular material can pass through the ultrafilter membrane, thus providing a versatile means of degrading and eliminating extraneous contaminating proteins. The ultrafilter concentration system is compared with the CsCl cushion system of poliovirus concentration, and both systems are further compared by banding virus and virus capsid material in CsCl by use of isopycnic centrifugation. PMID- 4341521 TI - Elimination of Mycoplasma contaminants from virus stocks by treatment with nonionic detergents. AB - Five nonionic detergents (Tweens 20, 40, 60, and 80, and Triton WR-1339) were tested for their ability to inactivate four Mycoplasma species which are common contaminants of animal cell cultures. Tween 20 was found to be the most effective, in that a concentration of 2.5 mg/ml completely inactivated cultures of M. hominis, M. hyorhinis, and Acholeplasma laidlawii within 1 hr and a culture of M. orale within 3 hr. The other detergents exhibited various degree of activity against the different mycoplasmas, with Triton WR-1339 being the least effective. The virucidal activity of the detergents was determined for six viruses. All four Tween compounds were highly virucidal for herpes simplex virus. Tween 20 also exhibited virucidal effects against vesicular stomatitis virus, California encephalitis virus, and Newcastle disease virus, and Tween 80 was found to be active against California encephalitis and Newcastle disease viruses. Detergent treatment procedures were effective in two instances in eliminating mycoplasma contaminants from virus preparations while the preparations retained most of the viral infectivity. The limitations of this technique for routine use are discussed. PMID- 4341523 TI - Prostaglandins and the epidermis. PMID- 4341524 TI - A review of the recent literature on diseases of the vulva. 3. Carcinogenesis and tumours. PMID- 4341522 TI - Differentiation between herpes simplex virus type 1 and type 2 strains by immunoelectroosmophoresis. AB - A method has been elaborated to differentiate between herpes simplex type 1 and type 2 viruses by immunoelectroosmophoresis. With rabbit immune sera cross absorbed with heterologous virus antigen, a distinct difference was shown between the two virus types. Herpes simplex type 1 virus tested against cross-absorbed type 1 antiserum gave two precipitin lines. Herpes simplex type 2 virus gave one precipitin line when tested against cross-absorbed homologous serum. When the viral antigens were tested against cross-absorbed heterologous immune sera, no or only very weak precipitin reactions were observed. The test is easy and rapid, requires relatively small quantities of antigen and antibody, and is suitable for typing of herpes simplex virus in diagnostic routine work. PMID- 4341525 TI - Development of herpes simplex virus in the isolated nuclei of HEp-2 cells. I. Viability of isolated HSV-infected nuclei. PMID- 4341526 TI - [Thin-layer electrophoresis of phenolic pharmaceutical preparations]. PMID- 4341527 TI - [Feminizing ovarian tumors]. PMID- 4341528 TI - The demonstration of plasmalogen with periodic acid. PMID- 4341529 TI - [Histological and histochemical findings in a substitute stomach created with a reverse small intestine segment. Comparative studies of the jejunum following gastrectomy]. PMID- 4341530 TI - Metabolism of aromatic compounds in bacteria. Purification and properties of the catechol-forming enzyme, 3,5-cyclohexadiene-1,2-diol-1-carboxylic acid (NAD + ) oxidoreductase (decarboxylating). PMID- 4341532 TI - Glutamyl transfer ribonucleic acid synthetase of Escherichia coli. II. Interaction with intact glutamyl transfer ribonucleic acid. PMID- 4341531 TI - Glutamyl transfer ribonucleic acid synthetase of Escherichia coli. I. Purification and properties. PMID- 4341533 TI - Polypeptide hormone interaction. II. Glucagon binding to lysolecithin. PMID- 4341534 TI - Polypeptide hormone interaction. 3. Conformational changes of glucagon bound to lysolecithin. PMID- 4341535 TI - Purification and properties of nuclear and cytoplasmic deoxyribonucleic acid polymerases from human KB cells. PMID- 4341537 TI - Isolation of C 55 -isoprenylpyrophosphate from micrococcus lysodeikticus. PMID- 4341538 TI - Enzymatic dephosphorylation of C 55 -isoprenylphosphate. PMID- 4341536 TI - Isolation and structural studies of sulfated glycoproteins of hog gastric mucosa. PMID- 4341539 TI - Purification and properties of C 55 -isoprenylpyrophosphate phosphatase from Micrococcus lysodeikticus. PMID- 4341540 TI - Studies on the glycosphingolipids of normal and virally transformed 3T3 mouse fibroblasts. PMID- 4341541 TI - Rat liver phenylalanine hydroxylase, an iron enzyme. PMID- 4341543 TI - Enhanced synthesis of phosphatidylethanolamine in chick embryo cells infected with Sendai virus of parainfluenza type 1. PMID- 4341542 TI - Dephosphorylation of the inhibitor component of troponin by phosphorylase phosphatase. PMID- 4341544 TI - Effect of trypsin on the infectivity of Sendai virus grown in several host cells. PMID- 4341545 TI - Electron microscopic studies on the replication of ibaraki virus. PMID- 4341546 TI - Human cytomegalovirus infection of cultured fibroblasts. I. Cytopathologic effects induced by an adapted and a wild strain. PMID- 4341547 TI - Human cytomegalovirus infection of cultured fibroblasts. II. Viral replicative sequence of a wild and an adapted strain. PMID- 4341548 TI - Role of leukocytes and lysosomal enzymes in antibody-mediated (hyperacute) rejection of renal heterografts. PMID- 4341549 TI - A new class of mutants with an elevated basal level of the galactose enzymes in E. coli. PMID- 4341550 TI - The renin-angiotensin-aldosterone system in normotensive and hypertensive patients with acromegaly. PMID- 4341551 TI - The relation of auxin-induced pea stem growth to cycl AMP treatment. PMID- 4341552 TI - Different effects of temperaturs on Type 1 and Type 2 Herpesvirus hominis in cell culture. PMID- 4341553 TI - Attenuation of certain neoplasias by chlorphenesin. 1. PMID- 4341554 TI - Improved assays for a variety of interferons. 1. PMID- 4341555 TI - Susceptibility to, and production of interferon by rhinovirus. 1. PMID- 4341556 TI - Altered vascular responsiveness: initial hypotensive mechanism of thiazide diuretics. 1. PMID- 4341558 TI - Studies of a rabbit herpes-like virus. 1. PMID- 4341557 TI - 3Beta-hydroxysteroid dehydrogenase activity in the adrenals of normal and hypophysectomized chick embryos. 1. PMID- 4341559 TI - In vitro approach to a correlation of cell susceptibility to viral infection with HL-A genotypes and other biological markers. 1. PMID- 4341560 TI - Studies on theophylline induced activation of glycogen phosphorylase in rat uteri. 1. PMID- 4341561 TI - Dexamethasone and corticosterone administration to pregnant rats: effects on pituitary-adrenocortical function in the newborn. 1. PMID- 4341562 TI - Effect of dibutyryl cyclic AMP on interferon production by cells treated with viral or nonviral inducers. 1. PMID- 4341563 TI - Effect of relative humidity on experimental transmission of sendai virus in mice. 1. PMID- 4341564 TI - Lymphocyte stimulation by cyclic AMP, GMP and related compounds. 1. PMID- 4341565 TI - Passive hemagglutinating antibodies in cerebrospinal fluids in herpesvirus hominis encephalitis. 1. PMID- 4341566 TI - Absence of bimodal ovulatory effect of PMS in the 30-day-old rat. 1. PMID- 4341567 TI - Arteriovenous fistulae in rabbit kidney studied by dye-dilution technique and by angiography. PMID- 4341568 TI - Absence of polymerase protein in virions of alpha-type rous sarcoma virus. AB - Noninfectious particles of a mutant of Rous sarcoma virus failed to exhibit DNA polymerase activity even with the use of the most sensitive synthetic template primer complexes. A neutralization blocking test against antibody to DNA polymerase revealed that these mutants did not contain protein immunologically related to the DNA polymerase. PMID- 4341569 TI - Lead poisoning: rapid formation of intranuclear inclusions. AB - A single dose of lead (0.05 milligram per gram of body weight) induced characteristic intranuclear inclusions in the epithelium of proximal tubules in rat kidney within 1 to 6 days. The development of the intranuclear inclusions is thus an acute manifestation of lead poisoning, not a delayed one, as has been thought hitherto. Cytoplasmic structures resembling the intranuclear inclusions and situated in the vicinity of endoplasmic reticulum were regularly found in cells bearing the pathognomonic intranuclear inclusions. The latter and the cytoplasmic structures may be derived from a common precursor, perhaps a soluble protein-lead complex. PMID- 4341570 TI - A new, long-lasting competitive inhibitor of angiotensin. AB - An analog of angiotensin II, [Sar(1), Ile(8)]-angiotensin II, has a potent and long-lasting competitive antagonistic effect against angiotensin II when tested for its myotropic action on the isolated rabbit aorta and for its effect on blood pressure in anesthetized cats and dogs. Compared to [Ile(8)]-angiotensin II, the new analog has equal antagonistic potency on the isolated system but a much greater potency in vivo. It is assumed that sarcosine in position 1 protects the peptide against enzymatic degradation and enhances its half-life. This study demonstrates that the modification in both positions 1 and 8 are important for the in vivo antagonistic potencies of angiotensin analogs. PMID- 4341571 TI - Delayed biliary duct obstruction after orthotopic liver transplantation. PMID- 4341572 TI - Clinicopharmacological study of synthetic ACTH. PMID- 4341574 TI - Effect of metronidazole (Klion) on entamoeba histolytica infection of adults. PMID- 4341573 TI - Effect of Miscleron (clofibrate) on the labelled lipoprotein uptake of the aorta in normal and cholesterol pretreated rabbits. PMID- 4341575 TI - [Pathology of diabetes mellitus in the white mouse infected with EMC-virus. Histological, electronmicroscopical and quantitative morphological findings in the islets of Langerhans]. PMID- 4341576 TI - Pecularities of lesions in viral and mycoplasma infections of the respiratory tract. PMID- 4341577 TI - [Neurological analysis of the action of tranquilizing agents--benzodiazepine derivatives]. PMID- 4341578 TI - Hidden factor of cardiac arrhythmia during light anesthesia. PMID- 4341579 TI - Fibrous dysplasia of the jaw bones. Analysis of five cases. PMID- 4341580 TI - Cricothyroid motor units. PMID- 4341581 TI - Hydrolytic activity of the perilymph in otosclerosis. A preliminary report. PMID- 4341582 TI - [Treatment of phenylketonuria with a new phenylalanine-free protein hydrolysate (Albumaid XP). II. Practical application and effect on weight, height and bone development in 21 days]. PMID- 4341583 TI - [A case of glycogenosis with recurrent hypoglycemia without enzymatic deficiency on liver biopsy]. PMID- 4341584 TI - [Hepatic glycogenosis without known enzyme deficiency with clinical and biological signs of type I Cori disease]. PMID- 4341585 TI - The migratory property of epidermis in vitro. PMID- 4341586 TI - [Dependence of blood sugar and thrombocyte count on 11 hydroxycorticosteroids in the calf]. PMID- 4341587 TI - [Influence of L-DOPA on night sleep in parkinsonian patients]. PMID- 4341588 TI - A cyclic AMP-stimulated protein kinase from amphibian ovary and oocytes. PMID- 4341589 TI - Comparison of the effects of Ca 2+ and Mg 2+ on the adenyl cyclase of beef brain. PMID- 4341590 TI - Cyclic 3',5'-AMP phosphodiesterase of human blood lymphocytes. PMID- 4341592 TI - Characterization of the specificity of intracellular phosphodiesterases in Bacillus subtilis. PMID- 4341591 TI - Cyclic nucleotide phosphodiesterase in pea seedlings. PMID- 4341593 TI - [Absence of change in the concentration of the hepatitis virus inhibitor MHV 3 (Piazza's factor) in mice treated with a immunosuppressive drug (azathioprine)]. PMID- 4341595 TI - Rapid separation of polychlorinated biphenyls from DDT and its analogues on silica gel. PMID- 4341594 TI - A method for the determination of 1-naphthol in urine. PMID- 4341596 TI - Polychlorinated biphenyls (PCB): effect on mitochondrial enzyme systems. PMID- 4341597 TI - Adenoid cystic carcinoma of external auditory canal. PMID- 4341598 TI - [Metastatic melanoma of fundus ventriculi]. PMID- 4341599 TI - [Formation of phytobezoars in the jejunum. A rare complication following gastric resection]. PMID- 4341600 TI - [Duodeno-biliary reflux of contrast medium]. PMID- 4341601 TI - [Diverticulosis of the appendix]. PMID- 4341602 TI - [Combined anomalies of the respiratory and gastrointestinal tracts]. PMID- 4341603 TI - [Animal experiments on inhalation bronchography using iodinated contrast powder]. PMID- 4341604 TI - [Radiological changes in the stomach after omentum transposition]. PMID- 4341605 TI - [Calcification in lympho-granulomatosis]. PMID- 4341606 TI - [Extensive retropharyng-oesophageal abscesses]. PMID- 4341607 TI - [Radiological pre-natal evaluation of foetal knee epiphyses]. PMID- 4341608 TI - [Indicative radiologic features in disseminated lipogranulomatosis (Farber's disease)]. PMID- 4341609 TI - [Fate of juvenile bone cysts following operations as shown radiologically]. PMID- 4341610 TI - [Radiological features of hypophosphatasia. Observations in two brothers with a malignant neonatal course]. PMID- 4341611 TI - [Osteochondrosis dissecans of the supratrochlear foramen]. PMID- 4341612 TI - [Congenital aplasia of the humero-radial joint]. PMID- 4341613 TI - [Possibilities for data processing in bone scanning]. PMID- 4341614 TI - [Periosteal activity of 85 Sr-marked bone transplants]. PMID- 4341615 TI - [Comparative studies on joint scanning using 99 m Tc and 113 m In]. PMID- 4341616 TI - [Problematics and methods of splenic scans using 99m Tc marked, heat-modified erythrocytes]. PMID- 4341617 TI - [Angiographic and isotope serial observations following renal injury in dogs]. PMID- 4341618 TI - [Functional diagnosis of compensated toxic adenomas of the thyroid using the scintillation camera]. PMID- 4341619 TI - [Extensive congenital esophageal stenosis]. PMID- 4341620 TI - [Rubella transmitted to placenta and fetus]. PMID- 4341621 TI - The effects of insulin, glucose and anti-insulin upon the activity of uridine diphosphate glucose glycogen -4-glucosyl-transferase EC2.4.1.11 in the rat placenta. PMID- 4341622 TI - Substituted carbamides: interrelationship between anticonvulsant activity and inhibition of nicotinamide adenine dinucleotide-dependent pyruvic acid oxidation. PMID- 4341623 TI - Dissolution of aspirin from tablets containing various buffering agents. PMID- 4341624 TI - Use of adsorbents in enhancement of drug dissolution. I. PMID- 4341625 TI - Use of adsorbents in enhancement of drug dissolution. II. PMID- 4341626 TI - Primary screening approach for anti-inflammatory agents utilizing an in vivo and a new in vitro method. PMID- 4341627 TI - Desorption of belladonna alkaloids from antacids for analysis. PMID- 4341628 TI - Cryptopleurine, an active antiviral alkaloid from Boehmeria cylindrica (L.) Sw. (Urticaceae). PMID- 4341630 TI - Variation in thermostability of herpes simplex virus during replication in different hosts. PMID- 4341629 TI - Studies on the neutralization of herpes simplex virus. V. Significance of the unneutralizable persistent fraction. PMID- 4341631 TI - [Anticonvulsants. 6. Treatment of infantile spasm with hypsarrhythmia]. PMID- 4341632 TI - [Anticonvulsants. 7. Treatment of myclonic-astatic epilepsy in small children]. PMID- 4341633 TI - [Rare benign, semi-malignant and malignant vascular tumours of the skin. Clinical course, histology and systemisation]. PMID- 4341634 TI - [Neurochemistry and tranquillisers]. PMID- 4341635 TI - Electrical stimulation of vestibular nuclei: effects on light-evoked activity of lateral geniculate nucleus neurones. PMID- 4341636 TI - Epidemic of subclinical infection with cytomegalovirus in an infant home. PMID- 4341637 TI - [Methods for the direct determination of blood ammonia without distillation]. PMID- 4341638 TI - [A method for the determination of free etiocholanolone in plasma]. PMID- 4341639 TI - [Investigation of taste buds of barbels in Corydoras paleatus Jenyns. I. Ultrastructure of the taste buds]. PMID- 4341640 TI - Evidence for spontaneous axon degeneration during peripheral nerve maturation. PMID- 4341642 TI - Intranuclear inclusions in mammotrophs of the female Mongolian gerbil. PMID- 4341641 TI - Effects of halothane on the ultrastructure of rat liver cells. PMID- 4341644 TI - Effect of electric convulsion therapy on urinary excretion of 3', 5' cyclic adenosine monophosphate. AB - Electric convulsion therapy (E.C.T.) was used in the treatment of 13 women inpatients suffering from depressive symptoms. Twelve of the patients showed a significant increase in urinary excretion of 3', 5' cyclic adenosine monophosphate (cAMP) on the day of treatment, whereas four controls who received all or part of the preliminary treatment but no electric shock showed a reduction. The results of this study are consistent with the hypothesis that the antidepressant action of E.C.T. is mediated through an increased production of cAMP in brain tissue. PMID- 4341643 TI - [Skeletal age and physical development of 12-year-old boys]. PMID- 4341645 TI - Efficacy of pertussis vaccines: a brighter horizon. AB - A study of pertussis infections in 186 children under 11 years of age in the Manchester region during 1969-71 suggests that recently-manufactured vaccines have been more effective than those made before 1967. The earlier vaccines were effective mainly against the serotypes of Bordetella pertussis possessing antigen 2, while those made from 1967 are more nearly equal in their effectiveness against thedi fferent serotypes. A booster dose of the earlier vaccines did not prevent infection with type 1,3 organisms, but we obtained a positive culture from only one child who had received four doses of recent vaccine.Simultaneous infection of a child with two or more serotypes was frequently seen. The predominant serotype in a patient was usually type 1,3; less often it was type 1,2,3 or type 1,2; it was never type 1. A change of serotype sometimes occurs during the course of the illness and is probably directed by the vaccination status of the patient in relation to the serotype of the initial infection.Our findings emphasize the need for vaccines to contain adequate amounts of all three pertussis agglutinogens, and for satisfactory immunization schedules to be used in their administration. PMID- 4341646 TI - Virus specific antibodies in multiple sclerosis. PMID- 4341647 TI - Comparison of ovulation-inducing effect between estrogen and progestin in the ovulation-blocked rat by chlorpromazine. PMID- 4341649 TI - Effect of ACTH in vivo on the phospholipid exchange between adrenal microsomes and mitochondria in vitro. PMID- 4341648 TI - Extra-adrenal action of metyrapone upon human growth hormone secretion in man. PMID- 4341650 TI - Comparative effects of ten anorectic drugs on sleep-wakefulness patterns in cats. PMID- 4341651 TI - Importance of nervous impulse flow for the neuroleptic induced increase in amine turnover in central dopamine neurons. PMID- 4341653 TI - Cell communication by chemical signals and the regulation of cyclic AMP in the development of a microorganism, Dictyostelium discoideum. PMID- 4341652 TI - Effect of catecholamines and angiotensin on cyclic AMP in rat aorta and tail artery. PMID- 4341654 TI - [Model reactions for oxidative phosphorylation. Studies on cyclic disulfides and corresponding dithioles using the hemin oxygen and the Cu(I)Cl-oxygen system]. PMID- 4341655 TI - Inhibition of DNA synthesis in RNA tumor viruses by antitumor antibiotics. PMID- 4341656 TI - [Regulation of cell growth in mammalian cell cultures]. PMID- 4341657 TI - [Circadian variation and -adrenergic increase of cAMP level in the mouse epidermis]. PMID- 4341659 TI - [Coenzyme-apoenzyme reciprocal action in transketolase from baker's yeast]. PMID- 4341658 TI - [Metabolism of N-acetylneuraminic acid in Morris hepatoma]. PMID- 4341660 TI - [Analysis of functional groups of bovine liver glutamate-dehydrogenase through chemical modification]. PMID- 4341661 TI - [Differential protein synthesis during differentiation of Physarum polycephalum: demonstration through density labeling]. PMID- 4341663 TI - [Bacterial photosynthesis: pyridine-nucleotide reduction in a chromatophore-free enzyme system from Rhodopseudomonas palustris]. PMID- 4341662 TI - [Respiratory chain of the mi-1-mutant of Neurospora crassa, a useful model for studies of oxidative phosphorylation]. PMID- 4341664 TI - [Phosphodiesterase inhibition as the action mechanism of various coronary vasodilator agents]. PMID- 4341665 TI - [Preparation of single cell suspensions from normal and regenerating rat liver and from Morris hepatoma 9121 and 5123 TC]. PMID- 4341666 TI - [Influence of arabinofuranosylcytosine on DNA synthesis in mouse lymphoma cells and in sea-urchin embryos]. PMID- 4341667 TI - [Influence of cathepsin B1 on phosphofructokinase and hexosediphosphatase]. PMID- 4341668 TI - [Influence of poly-L-lysin on the uptake of poly(I)-poly(C) by mammalian cells]. PMID- 4341669 TI - Inogranic tripolyphosphate (PPPi) as substrate for crystalline adenylate kinases. PMID- 4341670 TI - [Effects of mononucleotides on the morphogenesis in Anemia phyllitidis induced by gibberellins]. PMID- 4341671 TI - [Rapid labeling of a mitochondrially synthetized polypeptide of a cytochrome oxidase preparation from neurospora]. PMID- 4341673 TI - [Analysis of nucleid sequences for the determination of structural relations between nucleic and ribosomal ribonucleic acids in hepatoma cells]. PMID- 4341672 TI - [Dependence of the structure of cytochrome oxidase on the presence of products from mitochondrial protein synthesis]. PMID- 4341674 TI - [Increased extravascular albumin content and intracellular accumulation of great vesicles in the Morris-hepatoma 9121]. PMID- 4341675 TI - [Cytochrome oxidase from phylogenetically distant organism: spectral differences, constant mitochondrial contribution to structure]. PMID- 4341676 TI - [Modification of alcohol dehydrogenase from yeast with inactivators similar to coenzymes]. PMID- 4341677 TI - [Immunochemical studies on the microsomal NADH-dependent electron transport]. PMID- 4341678 TI - Subcutaneous mastectomy. PMID- 4341679 TI - Psychiatric consultation to a department of special education. PMID- 4341680 TI - Women in American radiology. PMID- 4341682 TI - Intranasal vaccination against infectious bovine rhinotracheitis: studies on early onset of protection and use of the vaccine in pregnant cows. PMID- 4341681 TI - Comparative efficacy of intranasally and parenterally administered infectious bovine rhinotracheitis vaccines. PMID- 4341683 TI - Differential diagnosis of bovine viral diarrhea-mucosal disease. PMID- 4341684 TI - Effect of topical vitamin A, antibiotic, mineral oil, and subconjunctival corticosteroid on corneal epithelial wound healing in the dog. PMID- 4341685 TI - Hypoglycemia. Insulin producing tumor of the pancreas. PMID- 4341687 TI - Carcinogenesis in tissue culture. 19. Photodynamic action of 4-nitroquinoline 1 oxide (4NQO) on mammalian cells in culture. PMID- 4341686 TI - Pigmented tumour arising in the skull of an infant. PMID- 4341688 TI - Carcinogenesis in tissue culture. 20. Electrokinetic changes in cultured rat liver cells associated with malignant transformation in vitro. PMID- 4341689 TI - -Aminoadipic -semialdehyde in cell nucleus, chromatin and histone. PMID- 4341690 TI - Studies on the tumor-host relationship. IV. Tumor cell agglutination with survival mouse serum. PMID- 4341691 TI - Glycerol as an enzyme-stabilizing agent: effects on aldehyde dehydrogenase. AB - The potassium-dependent aldehyde dehydrogenase (EC 1.2.1.3), from yeast is markedly altered by the addition of high concentrations of glycerol or other polyhydric alcohols to aqueous buffers. Several lines of evidence suggest that the three-dimensional structure near the active site is involved: (i) The stability of the enzyme when stored at 2 degrees , or when subjected to repeated freezing and thawing, depends upon the presence of at least 30% (v/v) glycerol. (ii) In the same solvent, the K(m) value for DPN and the binding constant for benzaldehyde decrease by 3- and 10-fold, respectively, compared with the values obtained for these substrates in fully aqueous media. (iii) Competitive inhibition by trivalent arsenicals with respect to DPN is no longer observed in glycerol; the inhibition becomes mixed and the K(i) values increase by 5- and 50 fold, respectively, with arsenite and Mapharsen. (iv) Essential sulfhydryl groups, which are easily carboxymethylated in aqueous buffers, are not readily available in either glycerol or mannitol. The data are consistent with a change in topography induced by polyhydric alcohols in which sulfhydryl groups near the DPN-binding site are displaced to a more protected environment, where their reactivity is reduced. Since the stabilizing effects of such alcohols are frequently encountered, these results may have application to other enzymes. PMID- 4341692 TI - Study of an oxygenated heme complex in frozen solution by Mossbauer emission spectroscopy. AB - We have used Mossbauer emission spectroscopy to study an oxygenated heme complex, produced in a frozen solution by nuclear decay from the isomorphous (57)Co labeled compound. The Mossbauer parameters agree with those obtained by Mossbauer absorption spectroscopy of oxyhemoglobin. Thus, a nonprotein environment for iron can duplicate the unique oxyhemoglobin Mossbauer spectrum. The electronic structure of the heme iron in oxyhemoglobin is not significantly influenced by the protein environment. Mossbauer emission spectroscopy can be useful in the investigation of heme proteins. PMID- 4341693 TI - Extensive symmetrical transcription of Simian Virus 40 DNA in virus-yielding cells. AB - Rapidly labeled RNA was extracted from monkey cells after infection with Simian Virus 40 (SV40) and exposure to short pulses of [5-(3)H]uridine late in infection. When this RNA was self-annealed, it became resistant to digestion with ribonuclease. The fraction of RNA that resisted the ribonuclease treatment decreased with increased labeling time, or when a short pulse of radioactivity was followed by incubation with unlabeled uridine and actinomycin D. The RNase resistant RNA was isolated by chromatography on Sephadex G-100 and shown to be double-stranded by its susceptibility to ribonuclease as a function of salt concentration and temperature. This behavior was not due to RNA-DNA hybrid formation, since deoxyribonuclease had no effect upon the double-stranded molecules, even after their denaturation. The relation of the double-stranded RNA to SV40 was demonstrated by the hybridization of about 50% (corrected value, >90%) of the separated RNA strands with component I of SV40 DNA from plaque purified virus. After self-annealing in formamide at low temperature, about 10% of the rapidly labeled, viral RNA sedimented at 13 S. This value corresponds in size to about 60% of the SV40 DNA.These observations indicate that late in infection of monkey cells, SV40 DNA is transcribed symmetrically over a considerable portion of its length, and that subsequently some sequences from one or both of the RNA strands are degraded. PMID- 4341694 TI - Biological activity of human chorionic gonadotropin released from testis binding sites. AB - The effect of testicular binding of human chorionic gonadotropin upon the biological activities of the hormone was examined by comparison of the binding and activation properties of (125)I-labeled gonadotropin before and after binding to rat testis in vitro. Biologically active (125)I-gonadotropin taken up by rat testis was dissocated from testis binding-sites at low pH and evaluated for its ability to bind again to testis, adenylate cyclase activation, and stimulation of steroidogenesis during subsequent incubation with fresh testis. Binding to tissue receptor-sites for 4 hr did not impair the biological properties of gonadotropin, though hormone remaining in the incubation medium had reduced affinity for tissue binding-sites during subsequent incubation with rat testes. In comparison to the original preparation, (125)I-labeled gonadotropin previously eluted from specific binding-sites of rat testis showed significantly increased binding activity and stimulation of cyclic AMP and testosterone release during further incubation with rat testes in vitro. The enhancement of biological activity of the eluted hormone is attributable to affinity purification of the original hormone preparation by selective uptake at receptorsites. These results demonstrate that gonadotropin is not inactivated or degraded during combination with gonadotropin receptors of rat testis. PMID- 4341695 TI - Antibody response in vitro to an animal virus: production of rabies virus neutralizing antibodies by mouse cells in culture. AB - Rabies virus neutralizing antibodies were produced in vitro by the exposure of mouse spleen cells to live and inactivated rabies virus suspensions and to sheep erythrocytes coated with rabies virus. These antibodies did not neutralize two other rhabdoviruses: Kern Canyon and vesicular stomatitis viruses, and were precipitable by treatment with an antiserum to mouse IgG. Removal of "glass adhering" cells from mouse spleen cell suspensions abolished the antibody response, which could be restored by the addition of mouse peritoneal exudate cells, rich in macrophages. PMID- 4341696 TI - Isolation of a pyrophosphoryl form of pyruvate, phosphate dikinase from Propionibacteria. AB - Pyruvate, phosphate dikinase from Propionibacterium shermanii catalyzes the formation of P-enolpyruvate, AMP, and inorganic pyrophosphate from pyruvate, ATP, and orthophosphate; the mechanism involves three partial reactions and three forms of the enzyme: pyrophosphoryl-enzyme, phosphoryl-enzyme, and free enzyme. The phosphoryl-enzyme was prepared by incubation with P-enolpyruvate and isolated by gelchromatography. The phosphoryl-enzyme was converted to (32)P(31)P-enzyme and [(32)P]Pi by incubation with [(32)P]PPi; 1 mol of pyrophosphoryl-enzyme was formed per mol of enzyme of molecular weight 150,000. The labeled enzyme released its radioactivity upon incubation with Pi or AMP to produce the expected [(33)P]PPi or [gamma-(32)P]ATP, respectively. Hydrolysis of the pyrophosphoryl enzyme with dilute acid yielded PPi. The beta,gamma-methylene analogue of ATP was reactive in exchange reactions with [(14)C]AMP. To our knowledge, this is the first proven example of a pyrophosphoryl-enzyme. PMID- 4341697 TI - Differences in the binding of fluorescent concanavalin A to the surface membrane of normal and transformed cells. AB - The binding of fluorescein-conjugated Concanavalin A to the cell surface has been studied in normal and transformed cells in interphase and mitosis. Binding to the cell surface was in the form of an incomplete ring of fluorescence, and the binding was inhibited by alpha-methyl-D-mannopyranoside. All the cells were fluorescent when treated with 25-250 mug/ml of fluorescent Concanavalin A. With 10 mug, the cells were all fluorescent after 30 min of binding, but after 0.5-5 min with 10 mug or 30 min with 1 or 2.5 mug, transformed interphase cells showed a higher percentage of cells with surface fluorescence than did normal interphase cells. Trypsinized normal and transformed interphase cells showed the same fluorescence. Binding with 2.5 mug at 4 degrees instead of at 24 degrees , gave a higher percentage of fluorescent cells with trypsinized than with untrypsinized transformed cells. Mitotic normal cells were similar to transformed interphase cells, whereas mitotic transformed cells were intermediate between normal and transformed interphase cells. The results indicate that the use of low concentrations of fluorescent Concanavalin A can show differences in surface fluorescence between normal and transformed, interphase and mitotic, and trypsinized and untrypsinized cells. It is suggested that the observed differences in fluorescence can be explained by differences in affinity of the lectin binding sites and/or differences in the clustering of sites. PMID- 4341698 TI - Activation of variants of hypoxanthine-guanine phosphoribosyl transferase by the normal enzyme. AB - Deficient hypoxanthine-guanine phosphoribosyl transferase (HGPRT; EC 2.4.2.8) enzymes from erythrocytes of patients with hyperuricemia and with the Lesch-Nyhan syndrome migrate 15% faster in polyacrylamide gel disc electrophoresis than the normal enzyme. A half-sister of two males with partial deficiency, who had 34% of normal HGPRT activity in her erythrocytes, yielded profiles containing two distinct zones of activity; one corresponded to the enzyme found in normal individuals and one to the variant of her half-brothers. However, in her profile her variant enzyme showed notably greater activity than that observed in her half brothers. This increase was due to an activation of the variant by normal enzyme. Electrophoresis of mixtures of normal enzyme with partially deficient enzymes from patients with hyperuricemia and with the Lesch-Nyhan syndrome also led to activation of deficient HGPRT variants by normal enzymes. Deficient variants were also activated by normal enzyme on filtration through Sephadex G-25. Experiments in which deficient variant enzymes were activated with purified normal enzyme labeled with (125)I indicated that deficient enzymes incorporate components of the normal enzyme. No such activation of deficient enzymes was ever obtained when mixtures of deficient and normal enzymes were put together in a test tube. PMID- 4341699 TI - Individual states in the cycle of muscle contraction. AB - By using appropriate analogs of ATP, isometrically-held glycerol-extracted psoas fibers from rabbits are forced successively into states corresponding to molecular species in the contractile cycle. In each state measurements are made of P[unk], a fluorescence polarization parameter thought to relate to attitude of S-1 moieties of the myosin molecules. Also, the value of P[unk] is measured during active tension development. It is suggested that this value is a time average of the P[unk] as S-1 moieties move through the various states of the cycle. Proposals are made concerning the sequence of states in the cycle. PMID- 4341700 TI - Sequence of spontaneous Epstein-Barr virus activation and selective DNA synthesis in activated cells in the presence of hydroxyurea. AB - The sequence of spontaneous Epstein-Barr virus activation was studied in P3HR-1 carrier cells and in P3HR-1(BrdU) cells made resistant to 5-bromodeoxyuridine. Virus activation was initiated during the normal cell cycle, and recruitment of additional virus-activated cells was prevented by the DNA inhibitors, 1-beta-D arabinofuranosylcytosine and hydroxyurea. Virus activation was followed by synthesis of the early antigen complex in the absence of additional detectable DNA synthesis. Early antigen synthesis was followed by hydroxyurea-resistant synthesis of new DNA, which in the case of P3HR-1(BrdU) cells was characterized by the appearance of thymidine kinase. The newly synthesized DNA banded in neutral cesium chloride at peaks corresponding to normal human DNA and Epstein Barr viral DNA. Synthesis of viral antigen was seen only in cells that had undergone hydroxyurea-resistant DNA synthesis. PMID- 4341701 TI - Emergence of insulin receptors on human lymphocytes during in vitro transformation. AB - Essentially no specific binding sites for insulin are detected in small lymphocytes freshly isolated from human blood. Insulin-binding sites appear on the lymphocyte surface during transformation in vitro with concanavalin A, and the number of these receptors increases sharply to reach a maximum between 24 and 46 hr after exposure to the mitogen. The appearance of de novo binding sites for insulin coincides with the increase in [(3)H]thymidine uptake into nuclear DNA and clearly precedes the appearance of enlarged, morphologically transformed cells. No changes in insulin-binding are detected in unstimulated control cultures. A maximum of about 350 molecules of insulin can bind per transformed lymphocyte, while less than six insulin molecules bind to an untransformed cell. Circulating human leukemic lymphoblasts bind about as much insulin as the lymphocytes transformed in vitro. Giant, polynucleated, transformed lymphocytes cultured in the presence of cytochalasin B bind about 10 times more insulin than transformed lymphocytes, which is in harmony with a 10-fold increase in cell surface area in these cells. Specific binding of insulin is a saturable process in transformed lymphocytes but not in the untransformed cells. In transformed cells, [(125)I]-insulin is displaced by as little as 2 ng/ml of native insulin, while in untransformed cells no significant displacement is observed with native insulin. Digestion of transformed cells with phospholipase C (EC 3.1.4.3.) enhances the specific binding of [(125)I]insulin 3-fold, but no effect occurs with untransformed cells. These observations indicate a possible functional role of insulin and of adenylate cyclase in cell growth and division. PMID- 4341702 TI - Preparation and properties of phospholipid bilayers containing rhodopsin. AB - Purified rhodopsin has been prepared containing less than 1.1 mol of phosphate per mol of protein. The purified rhodopsin has been incorporated into phosphatidylcholine bilayers, and the molecular interactions within the bilayers were investigated by the use of spin-labeled phosphatidylcholines. Rhodopsin appears to inhibit segmental motions of the hydrocarbon chains, an effect similar to that of cholesterol on phospholipid bilayers. PMID- 4341703 TI - Ribonucleic acid synthesis in cells infected with herpes simplex virus: controls of transcription and of RNA abundance. AB - Analysis of the kinetics of hybridization in liquid of labeled herpes simplex virus-1 DNA and excess viral RNA revealed the following: (i) Cells infected by herpes simplex virus-1 for 2 hr (before DNA synthesis) contain two classes of RNA molecules differing 140-fold in molar concentrations. The abundant and scarce RNAs are transcribed from 14 and 30% of the DNA, respectively. RNA extracted at 8 hr after infection (late RNA) also contains abundant and scarce classes differing 40-fold in molar concentrations; these are transcribed from 19 and 28% of viral DNA, respectively. Abundance competition hybridization tests indicate that the abundant RNA at 2 hr is a subset of the 8-hr abundant RNA. (ii) The abundant RNAs probably specify structural proteins, as indicated by estimates of DNA template required for structural proteins and by experiments showing that 19 of 24 proteins (corresponding to 68% of genetic information for structural proteins) are already made between 0.5 and 2 hr after infection. We conclude that there are two types of transcriptional controls, i.e., on-off and abundance controls, and that the synthesis of most structural components is an early viral function. PMID- 4341704 TI - Coupling of energy to active transport of amino acids in Escherichia coli. AB - Active transport of amino acids in isolated membrane vesicles of E. coli ML 308 225 is stimulated by oxidation of D-lactate, and this stimulation is dependent on electron transport [Kaback, H. R. & Milner, L. S. (1970) Proc. Nat. Acad. Sci. USA 66, 1008]. In attempting to relate these results to amino-acid transport in intact cells, we isolated mutants of E. coli ML 308-225 that contain defects in D lactate dehydrogenase (EC 1.1.2.4) and electron transport. Intact cells of these mutants are normal for transport of proline and alanine. We also isolated mutants defective in Ca,Mg-stimulated ATPase (EC 3.6.1.3), which is responsible for coupling electron transport to the synthesis of ATP. These mutants are defective in their ability to transport proline and alanine, as measured both in cells and isolated membrane vesicles. A possible role for the ATPase in coupling energy to active transport is discussed. PMID- 4341708 TI - [Angiographic differentiation of nephroblastoma]. PMID- 4341706 TI - In vitro synthesis of procollagen on polysomes. AB - The major collagenous products synthesized in a cell-free polysome preparation are pro-alpha1 and pro-alpha2, formed in a ratio of 2:1. They are the precursor forms of alpha1 and alpha2 chains of normal connective-tissue collagen that are also formed in small amounts. A procollagen peptidase activity has been demonstrated in the supernatant fraction that can account for the formation of alpha1 and alpha2 chains from their precursors. The polysomal system is activated by a salt extract of reticulocyte ribosomes and is inhibited by aurintricarboxylic acid, suggesting that the polysomes are able to initiate protein synthesis. PMID- 4341705 TI - Stimulation of adenosine 3':5'-cyclic monophosphate accumulation in anterior pituitary gland in vitro by synthetic luteinizing hormone-releasing hormone. AB - A near-maximal dose (20 ng/ml) of synthetic luteinizing hormone(LH)-releasing hormone/follicle-stimulating hormone(FSH)-releasing hormone added to incubated anterior pituitary tissue of male rats leads to concomitant increases of intracellular concentrations of adenosine 3':5'-monophosphate and of release of both LH and FSH. The stimulatory effect of LH-releasing hormone/FSH-releasing hormone is observed after a lag period of about 90 min and is progressive at later time intervals; a 3-fold stimulation of cAMP accumulation over control is seen after 210 min of incubation. Half-maximal stimulation of cAMP accumulation is observed between 0.1 and 1.0 ng/ml (0.1-1 nM) of LH-releasing hormone/FSH releasing hormone. In the presence of 10 mM theophylline, the stimulatory effect of LH-releasing hormone/FSH-releasing hormone on cAMP accumulation is similar to that observed in the absence of the inhibitor of cyclic nucleotide phosphodiesterase, indicating that the releasing hormone exerts its effect by specific activation of adenylate cyclase in LH- and FSH-secreting cells rather than by inhibition of cyclic nucleotide phosphodiesterase. Since the release of growth hormone, thyrotropin, prolactin, and adrenocorticotropic hormone is not affected by LH-releasing hormone/FSH-releasing hormone, and since cAMP stimulates the release of all six adenohypophyseal hormones. the observed changes of cAMP concentrations indicate specific stimulation of adenylate cyclase activity in LH and FSH-secreting cells of the adenohypophysis. PMID- 4341707 TI - Distribution of pyrimidine oligonucleotides in strands L and H of Bacillus subtilis DNA. AB - The distribution of pyrimidine oligodeoxynucleotide clusters in L and H strands of Bacillus subtilis DNA separated by methylated albumin-Kieselguhr has been determined. Preparations of native and single-stranded DNA were degraded with diphenylamine in formic acid, and the released isostichs with the general formula of Py(n)P(n+1) were separated on DEAE-cellulose by chain length. Eleven isostichs were obtained for strands L and H in unequal proportions. Each isostich fraction was subfractionated by base composition on DEAE-cellulose at pH 3.0. 61 Pyrimidine oligonucleotide clusters were separated from the H strand and only 46 from the L strand. The findings show a higher degree of asymmetry between the strands in the distribution of cytosine-rich clusters as compared with thymine rich clusters. The longest cytosine oligodeoxynucleotide present in both strands is of chain length 5. There is an unusually high distribution of thymine oligodeoxynucleotides of length 5-11. Up to chain length 6, the distribution of thymine oligodeoxynucleotides between the strands is about equal; from chain length 7 to 11 they occur predominantly in the H strand. PMID- 4341709 TI - [Malignant tumors in children]. PMID- 4341710 TI - [Poisoning by hydrocyanic acid and its derivatives]. PMID- 4341711 TI - [The phenomenon of predepressive cellular stimulation and anesthesia]. PMID- 4341714 TI - Extraction and determination of Aspergillus flavus metabolites-aflatoxins from meat products. PMID- 4341713 TI - [Cytomorphological and functional characteristics of a cell culture of guinea pig pancreas gland]. PMID- 4341715 TI - [Reactive astrocytes and epilepsy]. PMID- 4341712 TI - [Modeling of humoral regulation of cell proliferation in adult animal tissues]. PMID- 4341716 TI - [Ultrastructural localization of acid phosphatase in the rat neurohypophysis]. PMID- 4341717 TI - Plasma levels of ACTH and cortisol in man during droperidol-pentazocine anesthesia and surgery. PMID- 4341718 TI - [Medical economics and planning of psychiatric care]. PMID- 4341719 TI - Factors affecting arterial calcification associated with atherosclerosis. A review. PMID- 4341720 TI - Epidemiology of serum lipids in Southern Africa. PMID- 4341722 TI - Isolation of lipoprotein-acid mucopolysaccharide complexes from fatty streaks of human aortas. PMID- 4341721 TI - Lipid metabolism in prediabetics. PMID- 4341724 TI - Interaction between tadpole collagenase and human 2 -macroglobulin. PMID- 4341723 TI - A comparative study of a new drug MK 185 with clofibrate in the treatment of hyperlipidaemias. PMID- 4341725 TI - Resistance to collagenase: a characteristic of collagen fibrils cross-linked by formaldehyde. PMID- 4341726 TI - The ordering and relaxation times of water adsorbed on collagen fibers. PMID- 4341727 TI - Cytochrome c: resonance Raman spectra. PMID- 4341728 TI - The isolation of tryptophan-containing peptides by affinity chromatography. PMID- 4341729 TI - Granular cell lesions of the mouth. PMID- 4341730 TI - Orthostatic hypotension in bronchial carcinoma. PMID- 4341732 TI - [On 2 clavicular metastases revealing a primary cancer of the liver]. PMID- 4341731 TI - Papovaviruses and human disease. PMID- 4341733 TI - [Diagnosis and therapy of mixed salivary gland tumors]. PMID- 4341735 TI - Angiotensin II conformations. Infrared and raman studies. PMID- 4341734 TI - [Steroid biosynthesis in virilizing adenomas of adrenal glands]. PMID- 4341736 TI - Influence of thyroid hormones on enzyme activities of myelinating rat central nervous tissues. PMID- 4341737 TI - Purification and subunit interactions of yeast hexokinase. PMID- 4341738 TI - Multiplicity and origin of isoenzymes of lipoyl dehydrogenase. PMID- 4341739 TI - Octopine dehydrogenase. Evidence for a single-chain structure. PMID- 4341741 TI - Complete digestion of tyrosine transfer ribonucleic acid from Torulopsis utilis with pancreatic and T 1 ribonucleases. PMID- 4341740 TI - Pancreatic alkaline phosphatase and a tumour variant. AB - Alkaline phosphatase has been extracted from human pancreas with n-butanol and has been shown to have distinctive isoenzyme characteristics when compared with the enzymes of small intestine and of normal serum. The enzyme has been demonstrated histochemically in a carcinoma of the pancreas and also in an islet cell tumour and the tumour enzyme has been shown to be unique, not only electrophoretically, but in being remarkably heat sensitive and in being activated by low molarities of urea. PMID- 4341743 TI - Hydrolyses of 1-O-alkyl-, 1-O-alkenyl-, and 1-acyl-2-(1- 14 C)-linoleoyl-glycero 3-phosphorylcholine by various phospholipases. PMID- 4341742 TI - Cellular senescence in yeast caused by carbon-source starvation. I. Changes in activities of respiratory system and lipid peroxidation activity. PMID- 4341744 TI - Acid phosphatases from Fusarium moniliforme. II. Further studies on substrate specificity and mode of action of acid phosphatase II. PMID- 4341745 TI - Hepatitis-associated antigen in liver diseases. PMID- 4341746 TI - Angiotensin II antagonism. Structure-activity relationships of 8-substituted angiotensin II analogs. PMID- 4341747 TI - Antiparasitic nitroimidazoles. 1. Some 2-styryl-5-nitroimidazoles. PMID- 4341748 TI - Synthesis and antiviral activity of 4'-hydroxy-5,6,7,8-tetramethoxyflavone. PMID- 4341749 TI - Mutants of Escherichia coli with altered deoxyribonucleases. I. Isolation and characterization of mutants for exonuclease 3. PMID- 4341750 TI - Evidence for two sites in the lac promoter region. PMID- 4341751 TI - The possibility that adenosine triphosphate is an excitatory transmitter in guinea-pig seminal vesicle. PMID- 4341752 TI - [Pseudogout and articular chondrocalcinosis in the surgical clinic]. PMID- 4341753 TI - [Multisensory convergence on neurons of the motor cortex of unanesthetized cats]. PMID- 4341754 TI - [The reactions of cortical neurons upon viscero-somatic stimulation]. PMID- 4341755 TI - [Analysis of evoked discharges in hypothalamic neurons in response to somatosensory, acoustic and photic stimulation]. PMID- 4341756 TI - [Convergence of cortico- and rubrospinal influences on the motor neurons of the cervical portion of the spinal cord]. PMID- 4341757 TI - [Excitatory and inhibitory processes in the visual centers of Rana temporaria frogs]. PMID- 4341758 TI - [Inhibitory processes in fish olfactory bulb neurons]. PMID- 4341759 TI - [On the secondary messenger: cyclic AMP]. PMID- 4341760 TI - Adrenocorticotropin production by the intermediate lobe of the rat pituitary. An electron microscopic-immunohistochemical study. PMID- 4341761 TI - [The pathogenesis of radicular syndromes in lumbar osteochondrosis]. PMID- 4341762 TI - [A clinico-electroencephalographic study of patients with focal lesions of the hippocampo-amygdaloid complex (tumors of the medio-basal region of the temporal lobe)]. PMID- 4341763 TI - [The role of dopamine in the physiology and pathology of the basal ganglia]. PMID- 4341764 TI - Search for new cancer drugs: streptozotocin. PMID- 4341766 TI - An analytical method for the separation of sugar-methylated ribonucleosides from base-methylated and nonmethylated ribonucleosides. PMID- 4341765 TI - Simple methods for determination of methionine and cystine in legume seeds. PMID- 4341767 TI - Use of affinity matrices in determining steric requirements for substrate binding: binding of anthranilate 5-phosphoribosylpyrophosphate phosphoribosyltransferase from Salmonella typhimurium to Sepharose-Anthranilate derivatives. PMID- 4341768 TI - Volatile amines in mouse brain: a radioassay with picogram sensitivity. PMID- 4341769 TI - New assay for histidinol phosphate phosphatase using a coupled reaction. PMID- 4341770 TI - Studies on the de novo biosynthesis of NAD in Escherichia coli. II. Quantitative method for isolating quinolinic acid from biological materials. PMID- 4341771 TI - Biochemical and biophysical studies on cytochrome aa 3 . 8. Effect of cyanide on the catalytic activity. PMID- 4341772 TI - Evidence for the transport of manganous ion against an activity gradient by mitochondria. PMID- 4341773 TI - A new purification procedure and molecular properties of Pseudomonas cytochrome oxidase. PMID- 4341774 TI - Anaerobic-nitrate, symbiotic and aerobic growth of Rhizobium japonicum: effects on cytochrome P 450 , other haemoproteins, nitrate and nitrite reductases. PMID- 4341775 TI - Membrane potential generation by two reconstituted mitochondrial systems: liposomes inlayed with cytochrome oxidase or with ATPase. PMID- 4341776 TI - Liver nucleotide metabolism in relation to amino acid supply. PMID- 4341777 TI - Partial degradation of transfer RNAs and transfer RNA fragments by spleen phosphodiesterase as studied by disc electrophoretic methods. PMID- 4341778 TI - Partial degradation of transfer RNAs by sheep kidney nuclease. PMID- 4341779 TI - Properties of multiple serine-specific transfer RNAs (brewer's yeast) derived from countercurrent distribution. PMID- 4341781 TI - Interaction of estradiol- and progesterone-receptors with nucleoprotein: heat labile acceptor factors. PMID- 4341780 TI - The substrate specificity of bovine seminal vesicle fluid ribonuclease (ribonuclease AS). PMID- 4341782 TI - Comparison of antigenic properties of ribosomal proteins from Novikoff hepatoma and normal liver. PMID- 4341783 TI - Membrane separation and biogenesis of the outer membrane of yeast mitochondria. PMID- 4341784 TI - Proteolipid involvement in human erythrocyte membrane function. PMID- 4341785 TI - The proteins of the outer membrane of beef heart mitochondria. PMID- 4341786 TI - Phospholipid orientation in sarcoplasmic membranes: spin-label ESR and proton MNR studies. PMID- 4341787 TI - Preparation of purified myelin from ox intradural spinal roots by rate-isopycnic zonal centrifugation. PMID- 4341788 TI - Chloride flux via a shunt pathway in frog skin: apparent exchange diffusion. PMID- 4341789 TI - Phospholipid requirements for (Na + + K + )-ATPase activity: head-group specificity and fatty acid fluidity. PMID- 4341791 TI - A labile, serum-dependent uridine uptake function in mouse embryo cells. PMID- 4341790 TI - Characteristics of the membrane transport of sugars in the lens of the eye. PMID- 4341792 TI - Photoelectric effects at lipid bilayer membranes: theoretical models and experimental observations. PMID- 4341793 TI - Hormonal control in vitro of plasma membrane-bound (Na + -K + )-ATPase of rat liver. PMID- 4341794 TI - [Isolation and characterization of mitochondria from Yoshida AH 130 ascites hepatoma cells]. PMID- 4341795 TI - [Plasma renin activity in the course of acute viral hepatitis]. PMID- 4341796 TI - Cytomegalovirus myocarditis. PMID- 4341797 TI - Some biochemical effects of asbestos on macrophages. PMID- 4341799 TI - The origin of phleboliths. PMID- 4341798 TI - The site of vascular response to the -toxin of Clostridium perfringens type A in skeletal muscle. PMID- 4341800 TI - Amputation neuroma of the great auricular nerve after parotidectomy. PMID- 4341801 TI - [Kartagener's syndrome: report of four cases with critical assessment of the sinubronchial syndrome]. PMID- 4341803 TI - Polynucleotide ligase in rat tissues and ascites hepatoma. PMID- 4341802 TI - Strain difference in carcinogenesis by urethan administration to suckling rats. PMID- 4341804 TI - Effect of trypsin treatment of mouse fibroblasts and their SV40-transformed cells on the agglutinability by several phytoagglutinins having different sugar-binding properties. PMID- 4341805 TI - Immunoglobulin changes in a pediatric otolaryngic patient sample subsequent to T & A. PMID- 4341806 TI - Sequential conformational changes with the binding of NAD to rabbit muscle glyceraldhyde-3-phosphate dehydrogenase. PMID- 4341807 TI - Sequence studies of poliovirus RNA. I. Characterization of the 5'-terminus. PMID- 4341808 TI - [Vitamin resistant rickets in the daughters of a patient with nephrogenic diabetes insipidus]. PMID- 4341809 TI - [Cancer of a large duodenal papilla]. PMID- 4341810 TI - [Suppression and stimulation of plasma renin concentration in primary hyper aldosteronism]. PMID- 4341811 TI - Influence of cyclic guanosine-3',5'-monophosphate on the enzymatic hydrolysis of adenosine-3',5'-monophosphate. PMID- 4341812 TI - On the role of viruses in acute infectious diseases of the central nervous system. Clinical and laboratory studies on hospitalized patients. PMID- 4341813 TI - The development of immunofluorescent antibodies as compared with complement fixing and virus-neutralizing antibodies in human cytomegalovirus infection. PMID- 4341814 TI - IgM levels, specific IgM antibodies and liver involvement in cytomegalovirus infection. Report of 17 patients. PMID- 4341815 TI - Azidocillin treatment of enterococcal septicemia. PMID- 4341816 TI - An outbreak of infectious hepatitis in Southwest Greenland, 1971. An epidemiological and serological evaluation. PMID- 4341817 TI - Varicella and herpes zoster: differences in antibody response revealed by the platelet aggregation technique. PMID- 4341819 TI - Virions from progressive multifocal leukoencephalopathy: rapid serological identification by electron microscopy. AB - Virions were extracted directly from the brain of a patient with progressive multifocal leukoencephalopathy (PML). They were treated with antiserum to SV40, with rabbit antiserum to previous PML isolates, or with serum from another patient with the same disease and observed directly by electron microscopy. This procedure could be used for the rapid identification of the antigenic nature of virions in cases of PML. PMID- 4341818 TI - Infantile herpes zoster. PMID- 4341820 TI - Expression of lactate and malate dehydrogenases in tumors induced by SV40 and 7,12-dimethylbenz(a)anthracene. AB - Isozyme patterns of lactate and malate dehydrogenases were studied in tumors induced by SV40 and 7,12-dimethylbenz(a)anthracene and in established cultures of cells from these tumors. The expression of B polypeptide subunits of lactate dehydrogenase is suppressed similarly by both agents. This may be due to inactivation of the gene at the locus determining the B polypeptide subunit. Malate dehydrogenase isozyme patterns are not changed significantly by the virus or the carcinogen. PMID- 4341821 TI - The effect of scorpion venom and pure toxins on the cockroach central nervous system. PMID- 4341823 TI - [The clinical picture and surgical treatment of insulomas]. PMID- 4341822 TI - Observations on successive generations of tumors produced in hamsters by inoculation of SV40-transformaed cells. PMID- 4341824 TI - [Clinical evaluation of preoperative biopsies of the pancreas]. PMID- 4341825 TI - The effects of some hemicholinium analogues on acetylcholine metabolism and neuromuscular transmission. PMID- 4341826 TI - Comparative effects of cyclic guanosine 3',5'-monophosphate and its dibutyryl derivative on hepatic glycogenolysis. PMID- 4341827 TI - On the determination of the distribution functions of the lipoproteins in human sera. PMID- 4341828 TI - Effect of dietary rapeseed oil on the adrenocorticotrophin-induced production of prostaglandins in the rat adrenal. PMID- 4341829 TI - The metabolism of very low density lipoprotein proteins. II. Studies on the transfer of apoproteins between plasma lipoproteins. PMID- 4341830 TI - Acute necrotizing retinitis in a patient receiving immunosuppressive therapy. PMID- 4341832 TI - Enterovirus recovery from laboratory-contaminated samples of shellfish. PMID- 4341834 TI - [Infection caused by the cytomegalic virus (CMV) in the area of Montreal: an epidemiologic study]. PMID- 4341833 TI - Cell-wall composition and viomycin resistance in Rhizobium meliloti. PMID- 4341831 TI - Catecholamines--a symposium. PMID- 4341835 TI - Infectious mononucleosis: a disease syndrome of importance in public health. PMID- 4341838 TI - [Lymphogenous causes of swelling of the leg after reconstructive vascular surgery]. PMID- 4341837 TI - [Angio-scintigraphy of the myocardium]. PMID- 4341836 TI - [Complex angiographic diagnosis of recurrences of gynaecological tumours. Technique, indications, results]. PMID- 4341839 TI - [Measurements of muscle blood flow using Xenon-133-clearance after graduated ischaemic work in normals and in patients before and after vascular surgery]. PMID- 4341840 TI - [Pneumocystis pneumonia in adults]. PMID- 4341841 TI - [Traumatic lung prolapse]. PMID- 4341842 TI - [Extensive skull deformities due to arachnoid and porencephalic cysts]. PMID- 4341843 TI - [Brain scans in the diagnosis of recurrences of space-occupying intracranial lesions]. PMID- 4341844 TI - [Experimental investigations regarding tomography of the labyrinthine windows]. PMID- 4341845 TI - [Renal haematoma during anticoagulant therapy]. PMID- 4341846 TI - [The angiographic diagnosis of nephro-blastoma (Wilms' tumour)]. PMID- 4341848 TI - [Densitometry of medical radiographs using linear tomography]. PMID- 4341847 TI - [Advances in pancreas diagnosis by a combination of radiological and isotope methods]. PMID- 4341849 TI - [Intrathoracic collateral lymph vessels after surgical treatment of an infant chylothorax]. PMID- 4341850 TI - [Arterioportal fistula]. PMID- 4341851 TI - [Double femoral artery]. PMID- 4341852 TI - [Lumbosacral vertebral dislocation followed by spondylolisthesis]. PMID- 4341853 TI - Ossification of the ligamentum flavum. PMID- 4341854 TI - [Bilateral fatigue fracture of the first rib, caused by typical stress]. PMID- 4341855 TI - Bacterial food poisoning in perspective. PMID- 4341856 TI - Colostomy after-care and the stoma clinic. PMID- 4341857 TI - Action of oestradiol-17 and cyclic AMP on the synthesis of RNA, phosphoproteins and phospholipids in the uterus of ovariectomized rats in vitro. PMID- 4341858 TI - Plasma corticosterone in rats after electrochemical stimulation of the olfactory bulbs. PMID- 4341859 TI - The Bluebell Woods case: a problem of identification. PMID- 4341861 TI - Granular cell myoblastoma of the pituitary. Case report. PMID- 4341860 TI - Osteomyelitis and disc infection secondary to Pseudomonas aeruginosa in heroin addiction. Case report. PMID- 4341863 TI - Fringe medicine and the spirit--healing. PMID- 4341862 TI - The value of histological grading in the management of hydatidiform mole. PMID- 4341864 TI - Failure of rescue between influenza A viruses. PMID- 4341865 TI - Acute Epstein-Barr virus infections in children. PMID- 4341866 TI - [Antigenic properties of parainfluenza viruses isolated in Kiev]. PMID- 4341867 TI - Testicular tumors. Histologic and epidemiologic assessment. PMID- 4341868 TI - Wilms' tumor. Effect of chemotherapy on survival. PMID- 4341869 TI - The enigma of multiple sclerosis. PMID- 4341870 TI - [Poliomyelitis in Poland in the years 1969 through 1970]. PMID- 4341871 TI - The diagnosis of primary malignant tumours of the liver. Findings in 48 consecutive patients. PMID- 4341872 TI - Radiological investigations of the urinary tract. PMID- 4341873 TI - Motor nerve conduction velocity and electromyogram in carbon disulphide poisoning. PMID- 4341874 TI - [Electromyographic studies of uremic neuropathies and myopathies]. PMID- 4341875 TI - [Interactions of experimental acute bilateral and assymetrical foci]. PMID- 4341876 TI - [Automatic analysis of modifications in the evoked cortical potentials]. PMID- 4341877 TI - [Effects of atropine on the experimental epilepsy in the cat]. PMID- 4341878 TI - [Synacthen in the therapy of Lennox-Gastaut syndrome]. PMID- 4341879 TI - [2 cases of esophageal compression due to tuberculous lymphadenitis]. PMID- 4341880 TI - [Cancerized ulcer of the body of the stomach]. PMID- 4341881 TI - [Prepyloric epithelioma of camouflaged development]. PMID- 4341882 TI - [Malignant schwannoma of the stomach with exogastric development]. PMID- 4341883 TI - [Malignant schwannoma of the gastric stump in a formerly gastrectomized patient]. PMID- 4341884 TI - [Cancer of a long-standing gastroenterostomy]. PMID- 4341885 TI - [Concomitant drug-induced perforation (betamethasone), in free peritoneum, of 2 ulcers, 1 gastric, 1 bulbar. Secondary double covering]. PMID- 4341886 TI - [Cirsoid aneurysm of the duodenal wall]. PMID- 4341887 TI - [Leiomyoma of the 2d portion of the duodenum]. PMID- 4341888 TI - [Acute peritoneo-intestinal tuberculosis with duodeno-colonie fistula]. PMID- 4341889 TI - [Ileo-colic Crohn's disease]. PMID- 4341890 TI - [Ileo-colic Crohns disease and left rectocolitis]. PMID- 4341891 TI - [Cancer of the sigmoid fistulized into the small intestine]. PMID- 4341893 TI - [Congenital stenosis of the papilla. Secondary lithiasis of the common bile duct and calcifying pancreatitis in a 26-year-old woman]. PMID- 4341892 TI - [Perforation of the sigmoid following a barium enema: ulcer of the colon?]. PMID- 4341894 TI - [Cancer of Vater's ampulla simulating a D2 ulcer]. PMID- 4341895 TI - [Chronic pancreatitis caused by lithiasis of Wirsung's duct]. PMID- 4341896 TI - [A case of peritonitis encapsulans]. PMID- 4341897 TI - [Traumatic rupture of the diaphragm with hernia of the stomach, spleen, colon and greater omentum into the thorax]. PMID- 4341898 TI - [Clinical and serological data in children with acute herpetic stomatitis]. PMID- 4341899 TI - Effect of polychlorinated biphenyls on hepatic microsomal enzymes in the rat. PMID- 4341900 TI - Smallpox: laboratory diagnosis. PMID- 4341901 TI - An analytical description of the line element in the zone-fluctuation model of colour vision. II. The derivation of the line element. PMID- 4341903 TI - [On the mechanism of restoration of visual field changes due to optic nerve disturbance]. PMID- 4341904 TI - [Disc electrophoretic analysis of cerebrospinal fluid proteins in the disturbances of optic nerve. 3. The changes of protein fraction of lumbar cerebrospinal fluid in the brain tumor with special reference to its locality]. PMID- 4341902 TI - Hormonal studies in a patient with the testicular feminization syndrome. Case report. PMID- 4341905 TI - High expectations of long-term ex-state hospital patients. PMID- 4341907 TI - Cytomegalovirus syndrome following renal transplantation. PMID- 4341906 TI - [Study of the degeneration of nerve fibers by sciatic nerve compression in rats treated with parotid extract]. PMID- 4341908 TI - Prevention of experimental renovascular hypertension by caval portal shunt. PMID- 4341909 TI - The release of collagenase as an inactive proenzyme by bone explants in culture. AB - 1. A latent collagenase, activated only by limited proteolysis, was found in culture media of mouse bone explants. It could be activated by trypsin or, less efficiently, by chymo-trypsin. Skin explants also released latent collagenase. 2. Bone collagenase attacks native collagen at about neutral pH when it is in solution, in reconstituted fibrils or in insoluble fibres, producing two fragments representing 75 and 25% of the molecule. It requires calcium and is inhibited by EDTA, cysteine or serum. 3. Latent collagenase is not activated by trypsin-activated collagenase but by a distinct unidentified thermolabile agent present in a latent trypsin-activatable state in the culture media, or by purified liver lysosomes between pH5.5 and pH7.4. Trypsin activation decreases the molecular weight of latent collagenase from 105000 to 84000 as determined by gel filtration. 5. The latency of collagenase is unlikely to be due to an enzyme inhibitor complex. Although some culture media contain a collagenase inhibitor, its presence is not constant and its molecular weight (at least 120000) is not compatible with the decrease in molecular weight accompanying activation; also combinations of collagenase with inhibitor are not reactivated by trypsin. Moreover, the latency remains after gel filtration, or treatment by high dilution, exposure to pH values between 2.5 and 10, or high ionic strength, urea or detergent. 6. It is proposed that latent collagenase represents an inactive precursor of the enzyme, a ;procollagenase', and that the extracellular activity of collagenase is controlled by another protease that activates procollagenase by a limited proteolysis of its molecule. PMID- 4341913 TI - Xerographic recording of mammograms. PMID- 4341911 TI - The turnover of protein in discrete areas of rat brain. AB - 1. Rats were injected serially with [(14)C]glucose to obtain a constant specific radioactivity of brain amino acids. Measurements with this system for periods of up to 8h gave an apparent mean half-life for protein in whole brain of 85h (indicating the presence of a protein fraction with much more rapid turnover than this). 2. The half-lives of proteins in the granule-cell, molecular and white matter layers of cerebellum were also determined. These had values of 33, 59 and 136h respectively. In addition, the incorporation into protein in six layers of the cerebral cortex, subjacent white matter and five layers of Ammon's horn was studied. All cell-body layers incorporated amino acids at about the same rate irrespective of location, and these rates were considerably higher than those for incorporation into proteins in areas rich in dendrites or fibre tracts. 3. A new method for measuring small amounts of glutamate with a cyclic enzyme system is presented. PMID- 4341912 TI - The cytostatic action of extracellular NAD in tumour-bearing mice. AB - Repeated injections of NAD led to a dose-dependent inhibition of cell proliferation in tumour-bearing mice (Ehrlich ascites carcinoma and a murine mastocytoma). NAD proved clearly superior to other adenine nucleotides, including 3',5'-cyclic AMP. Experiments with differently labelled NAD and studies on HeLa cultures showed that NAD is relatively slowly degraded by extracellular enzymes to AMP and adenosine, which probably represents the true cytostatic agent.The superiority of NAD in vivo to other adenine nucleotides and to adenosine itself can be explained by the rate-limiting hydrolysis of NAD to AMP with a sustained production of cytostatic concentrations of adenosine. This may represent a new kind of "poisoning" by a potentially cytostatic compound brought about by the action of extracellular enzymes. PMID- 4341914 TI - Skeletal dimensions as an indication of foetal maturity. PMID- 4341915 TI - [Carcinoma in childhood]. PMID- 4341916 TI - [Comparative biochemical studies on transurethral and transvesical prostatectomy. II. Behavior of plasma hemoglobin and haptoglobin, protein and fat metabolism, phosphatases]. PMID- 4341917 TI - Immunogenicity of a soluble membrane antigen from adenovirus-12 induced tumor cells demonstrated in inbred hamsters (PD-4). PMID- 4341918 TI - The antiviral activity of isoprinosine. PMID- 4341919 TI - Hydrolytic enzymes of some periphytic marine bacteria. PMID- 4341920 TI - Structure-activity relationship in the taste effect of ribonucleotide derivatives. PMID- 4341921 TI - Antitumor effects of pentamethylene bismethanethiosulfonate hydrolysates and difunctional bunte salt. PMID- 4341922 TI - 2-Methoxyestrone 3-glucuronide: a new biliary metabolite in the rat. PMID- 4341923 TI - [Plasmatic ACTH levels in acromegaly]. PMID- 4341925 TI - Family attitude in nursing home placement. PMID- 4341924 TI - Adenosine 3',5'-,monophosphate (cyclic AMP) and secretion in the canine stomach. PMID- 4341926 TI - Adrenal and pituitary response of the Apollo 15 crew members. PMID- 4341928 TI - The radioimmunoassay of angiotensin I and angiotensin II. PMID- 4341927 TI - Evidence for the presence of neurophysin in tumors producing the syndrome of inappropriate antidiuresis. PMID- 4341929 TI - Insulin. PMID- 4341930 TI - Adrenocortical function in foetal, neonatal and young pigs. PMID- 4341932 TI - Corticotrophin radioimmunoassay. PMID- 4341931 TI - Studies on the mechanism of action of angiotensin on fluid transport by the mucosa of rat distal colon. PMID- 4341933 TI - Regulation of succinate dehydrogenase in Escherichia coli. PMID- 4341934 TI - Facilitation of monosynaptic excitatory synaptic potentials in spinal motoneurones evoked by internuncial impulses. AB - 1. Descending tracts and primary afferent fibres were chronically degenerated in the lumbosacral cord of the cat, and attempts were made to evoke monosynaptic e.p.s.p.s in motoneurones by stimulation of interneurones with a pair of fine electrodes inserted into the cord.2. The reversal potential of monosynaptic e.p.s.p.s so produced was more negative than that measured for monosynaptic e.p.s.p.s produced by afferent impulses.3. Monosynaptic e.p.s.p.s evoked in motoneurones by internuncial impulses showed a significantly greater facilitation than those produced by afferent impulses.4. Monosynaptic e.p.s.p.s in a motoneurone produced by supramaximal intraspinal stimuli often revealed a fluctuation in amplitude. In such cases, when two successive stimuli were applied at a short interval, the mean amplitude of the second e.p.s.p.s was greater than that of the first e.p.s.p.s. This facilitation was associated with a decrease in the coefficient of variation of the e.p.s.p. amplitude fluctuation.5. The degree of facilitation of monosynaptic e.p.s.p.s evoked by internuncial impulses was not related to the amount of transmitter released by the preceding impulses.6. It is concluded that facilitation of monosynaptic e.p.s.p.s evoked by both afferent and internuncial impulses is based on the same mechanism and that the degree of facilitation of e.p.s.p.s is entirely determined by the nature of presynaptic elements. PMID- 4341935 TI - Quantal components of the inhibitory synaptic potential in spinal mononeurones of the cat. AB - 1. Monosynaptic i.p.s.p.s were produced in spinal motoneurones of the cat by stimulation of a pool of interneurones following chronic degeneration of descending tracts and primary afferent fibres in the lumbosacral cord.2. Monosynaptic i.p.s.p.s so evoked by supramaximal stimuli often showed a fluctuation in amplitude with occasional failures of response.3. When two successive stimuli were applied at a short interval, the mean amplitude of the second i.p.s.p.s was greater than that of the first. This facilitation was associated with a decrease in the number of failures, a decrease in the coefficient of variation of the amplitude distribution and an increase in the probability of occurrences of large i.p.s.p.s.4. A statistical analysis of the i.p.s.p. amplitude fluctuation showed that the monosynaptic i.p.s.p. is composed of discrete unit potentials evoked with a certain probability in a manner described by a binomial law.5. The application of strychnine decreased the mean amplitude of i.p.s.p.s with little change in the coefficient of variation of the i.p.s.p. amplitude distribution.6. It is concluded that the release of inhibitory transmitter occurs in quantal steps and that strychnine blocks primarily the post synaptic receptors for the inhibitory transmitter. PMID- 4341936 TI - An attempt at an analysis of the factors determining the time course of the end plate current. I. The effects of prostigmine and of the ratio of Mg 2+ to Ca 2+ . AB - 1. An attempt was made to analyse the factors which might determine the time course of the falling phase of the end-plate current.2. The end-plate current was measured by ;clamping' the membrane potential during neuromuscular transmission.3. The falling phase of the end-plate current was found to consist of a non-exponential, and an exponential portion, the duration of both of which varies under different experimental conditions.4. The results suggest that the rate constants determining the dissociation of the receptor-mediator complex seem greatly to influence the time course of the end-plate current. PMID- 4341937 TI - An attempt at an analysis of the factors determining the time course of the end plate current. II. Temperature. AB - 1. An attempt was made to analyse further the factors which might determine the time course of the falling phase of the end-plate current.2. The end-plate current was measured by ;clamping' the membrane potential during neuromuscular transmission. The falling phase of the end-plate current had an exponential and a non-exponential portion.3. The exponential portion of the falling phase of the end-plate current was found to be strongly affected by changes in the membrane potential and by relatively small changes in temperature.4. It is suggested that the two rate constants which determine the dissociation of the receptor-mediator complex are affected by both temperature and the membrane potential. Under certain experimental conditions these two rate constants alone seem to determine the time course of the exponential portion of the falling phase of the end-plate current. PMID- 4341938 TI - The effect of tetanus toxin at the neuromuscular junction in the goldfish. AB - 1. The effect of tetanus toxin on neuromuscular transmission in the abductor superficialis muscle of the goldfish fin has been investigated.2. The abductor superficialis muscle is multiply innervated and junction potentials (j.p.s) and miniature junction potentials (min.j.p.s) can be recorded with an intracellular micro-electrode at any point of impalement. Intracellular recordings have been made from muscles in which neuromuscular transmission has been blocked, either completely, or partially, by I.M. injection of tetanus toxin. In addition, the tension response of both acutely and chronically toxin-blocked muscles to carbachol (1 x 10(-4)M) has been investigated.3. As the neuromuscular block proceeds, the frequency of min.j.p.s falls, and some time after the muscle has stopped responding to nerve stimulation the min.j.p.s disappear.4. In muscles in which the block has not yet proceeded to completion, it has been found that the reduction in the frequency of the min.j.p.s is unaccompanied by any change in their range of amplitudes.5. The min.j.p. frequency can be greatly increased in such incompletely blocked preparations by repetitive stimulation of the nerve (at, for example, 100/sec for 10 sec). The min.j.p.s obtained are indistinguishable from those seen in the absence of stimulation. Additionally, min.j.p.s can be evoked by similar repetitive stimulation in muscles which are completely blocked, and in which no min.j.p.s are seen without stimulation, so long as the block has only been complete for a short time.6. The tension response to carbachol of muscles which have been paralysed by tetanus toxin for only a few days is identical with that of normal muscles. In contrast, chronically toxin paralysed muscles contract more rapidly, usually more vigorously, and relax more rapidly than normal muscles.7. It is concluded that tetanus toxin prevents both the nerve-stimulated and spontaneous release of acetycholine from the presynaptic terminals in the abductor superficialis muscle of the goldfish fin. PMID- 4341939 TI - Some characteristics of the fast feed-back control of corticotrophin secretion. PMID- 4341940 TI - [Antitumor activity of adriamycin]. PMID- 4341942 TI - [Determination of plasma renin concentration using radioimmunoassay of angiotensin I]. PMID- 4341941 TI - ["Transsexualism" in testicular feminization]. PMID- 4341944 TI - Studies of primary hyperlipoproteinemias. II. Diagnosis and classification. PMID- 4341943 TI - Different effects of lipolytic hormones and phosphodiesterase inhibitors on cyclic 3',5'-AMP levels in isolated fat cells. PMID- 4341945 TI - Studies of primary hyperlipoproteinemias. 3. Disturbances in the carbohydrate metabolism. PMID- 4341946 TI - Malignant transformation of eccrine spiradenoma. PMID- 4341947 TI - Fatigability in brucellosis. An electromyographic study. PMID- 4341948 TI - Polish averaging computer "ANOPS" applied for automatic recording of histograms of duration of muscle action potentials. PMID- 4341949 TI - [Disturbances of dromotropism in the trifascicular system]. PMID- 4341950 TI - The relationship between brain norepinephrine and aggressive behavior. PMID- 4341951 TI - Cholinergic synapses in the limbic system and behavioral inhibition. PMID- 4341953 TI - The possible role of the adrenergic systems of the cortex in learning. PMID- 4341952 TI - Psychoactive drugs and neurotransmitters: differentiating dopamine and norepinephrine neuronal functions with drugs. PMID- 4341954 TI - Drug-induced extrapyramidal disorders. PMID- 4341956 TI - Myelography with water soluble medium. PMID- 4341955 TI - [Effects induced by the treatment with amantadine on habituation of trigemino facial reflexes in Parkinsonian patients]. PMID- 4341957 TI - [Effect of insulin and ACTH load on the functional condition of the sympathico adrenal system in patients with cardiac insufficiency]. PMID- 4341958 TI - Blood platelet as a model for action of drugs and bacterial products. PMID- 4341959 TI - [Therapy and follow-up study of the prostatic neoplasm]. PMID- 4341961 TI - [Role of B. pertussis agglutinogens (factor 3) in immunity]. PMID- 4341960 TI - [Protective antigens of pathogenic microorganisms (review)]. PMID- 4341962 TI - Revised amide location for porcine and human adrenocorticotropic hormone. PMID- 4341963 TI - Blood bioassayable thyrotrophin and corticosteroid levels during various physiological and stress conditions in the rabbit. PMID- 4341965 TI - Relationship of sleep to neuroanatomical circuits, biochemistry, and behavior. PMID- 4341964 TI - The search for the memory trace. PMID- 4341966 TI - Effect of alternate-day, single-dose, corticosteroid therapy on pituitary-adrenal function. PMID- 4341967 TI - Tremorgenic toxin from Penicillium veruculosum. AB - A new mycotoxin that produces severe tremors and acute toxicity when administered orally or intraperitoneally (ip) to mice and 1-day-old cockerels was obtained from a strain of Penicillium verruculosum Peyronel isolated from peanuts. The ip 50% lethal dose (LD(50)) of this tremorgen was 2.4 mg/kg in mice and 15.2 mg/kg in chickens. Orally administered LD(50) values for the toxin were 126.7 mg/kg in mice and 365.5 mg/kg in chickens. The trivial name "verruculogen" is proposed for this tremorgenic mycotoxin. Physical and chemical characteristics of the mycotoxin are described. PMID- 4341968 TI - Use of polyelectrolytes and electron microscopy for detection of viruses from stool. AB - Insoluble polyelectrolytes (PE60) were used for the concentration of viruses from stool specimens, confirming the results of Wallis et al. (1969). Ten percent suspensions inoculated with poliovirus type 3 were used in these experiments. A small number of stool specimens from patients naturally infected with enteroviruses were also tested. Preferential adsorption of viruses to PE60 was maximum at a pH range of 4.5 to 6.0. The elution of the adsorbed viruses was optimal at pH 8.5. Other parameters were also investigated. Electron microscopy was used successfully to detect the eluted viruses. PMID- 4341970 TI - Fluoride acquisition in vitro by sound human tooth enamel from sodium fluoride and ammonium silicofluoride-phosphate solutions. PMID- 4341971 TI - Non-responsive coeliac disease. PMID- 4341969 TI - Susceptibility of mammalian (hamster) cell culture to infection with herpesvirus of turkeys. AB - Herpesvirus of turkeys (HVT) infected and replicated in hamster kidney cells as evidenced by cytopathic effects, intranuclear inclusions, and by the presence of herpesvirus particles as seen by electron microscopy. Additional evidence for the presence of HVT in cell cultures was determined by the serum neutralization, complement fixation, and the fluorescent-antibody tests. PMID- 4341973 TI - [Results of an intravenous ACTH rapid test in the diagnosis of adrenal insufficiency]. PMID- 4341972 TI - Influence of pH on radioimmunoassay of angiotensin I. PMID- 4341974 TI - Evidence of adrenergic--cholinergic interaction in the central nervous system. II. Dopamine and its analogues. PMID- 4341975 TI - In vitro effects on cardiac norepinephrine of angiotensin II and of two indirectly acting sympathomimetic amines (amphetamine and tyramine). A study of their combinations. PMID- 4341976 TI - Adenyl cyclase activity in bovine adrenal medulla. PMID- 4341977 TI - Physiological and histochemical properties of the soleus muscle after denervation of its antagonists. PMID- 4341979 TI - Sickle cell anemia--the disease of challenge. PMID- 4341978 TI - Convulsive responses in rats with hippocampal and neocortical lesions. PMID- 4341980 TI - A behavioral approach to irrational anxiety and insomnia. (Decreasing prescription suicides). PMID- 4341981 TI - Abortion referral in a large college health service. PMID- 4341982 TI - Acute cholecystitis associated with surgery and trauma. PMID- 4341983 TI - Our experience with cancer of the head and neck. PMID- 4341984 TI - Modification of present procedures for the determination of conjugated estrogens (equine) in various low-dosage forms. PMID- 4341985 TI - Study of the silicic acid procedure of Armour and Burke for the separation of polychlorinated biphenyls from DDT and its analogs. PMID- 4341986 TI - Regulation of mitochondrial respiration in senescence. PMID- 4341987 TI - Lesch-Nyhan mutation: the influence of population density on purine phosphoribosyltransferase activities and exogenous purine utilization in monolayer cultures of skin fibroblasts. PMID- 4341988 TI - The ultrastructure and ontogeny of pollen in Helleborus foetidus L. IV. Pollen grain maturation. PMID- 4341989 TI - Multiple symbiosis in a leafhopper, Helochara communis Fitch (Cicadellidae: Homoptera): envelopes, nucleoids and inclusions of the symbiotes. PMID- 4341990 TI - Helical filaments in the glial cells of the locust (Schistocerca gregaria). PMID- 4341991 TI - On the physical identity of scintillons: bioluminescent particles in Gonyaulax polyedra. PMID- 4341992 TI - Fine-structural studies on spontaneous and induced fusion of higher plant protoplasts. PMID- 4341993 TI - Origin and structure of embryoids arising from epidermal cells of the stem of Ranunculus sceleratus L. PMID- 4341994 TI - The fine structure of the embryogenic callus of Ranunculus sceleratus L. PMID- 4341995 TI - Ultrastructure of the pulvinar of the squirrel monkey. PMID- 4341996 TI - [Cervico-vaginal carcinoma. Diagnostic and therapeutic problems raised by specimens of cylindrical pattern]. PMID- 4341997 TI - The effect of two methods of cooking and cooling on Clostridium welchii and other bacteria in meat. AB - A comparison was made of beef cooked in conventional and moist air (Rapidaire) ovens. In both large (ca. 4.5 kg.) and small (ca. 2.7 kg.) joints, spores of Clostridium welchii survived after cooking but vegetative cells, Escherichia coli, and Staphylococcus aureus, did not, regardless of the type of oven used.Cooling at room temperature after cooking permitted growth of Cl. welchii. Although some multiplication also occurred in the centre of large roasts cooled under refrigeration, the viable counts were considered too low to constitute a potential health risk. PMID- 4341999 TI - Adenovirus, parainfluenza virus and respiratory syncytial virus antibodies in the sera of Jamaicans. AB - Surveys for respiratory virus antibodies in the Jamaican population have shown that adenovirus, respiratory syncytial virus and parainfluenza types 1 and 3 virus antibodies are acquired early in life. The incidence of haemagglutination inhibiting antibodies to parainfluenza viruses increases rapidly with age and almost all adults possess parainfluenza type 3 antibody, usually in high titre. Parainfluenza type 1 antibodies are only slightly less common. Complement-fixing antibodies to the adenovirus group were also observed to increase in incidence with age.Complement-fixing antibody to respiratory syncytial virus was less common in Jamaican sera than antibody to the other respiratory viruses described here. The highest titres were observed in the youngest age-group. PMID- 4341998 TI - The influence of the route of immunization on the protection of mice infected intracerebrally with Bordetella pertussis. AB - The development of immunity in mice to Bordetella pertussis induced by intracerebral, intravenous or intraperitoneal vaccination was analysed in terms of the viable bacteria in the brain after intracerebral challenge, the serum antibodies, and protection against the sublethal infection of the lung that follows intranasal inoculation.A vaccine introduced intracerebrally was five to ten times more effective than that given intraperitoneally or intravenously, as measured for each route by the amount of vaccine required to protect half the mice against an intracerebral challenge 14 days later (ImD 50). Intracerebral vaccination induced higher antibody titres than vaccination by the other two routes. The survival of infected mice given 1-3 ImD 50 doses of vaccine intracerebrally 14 days before, followed a pattern similar to that after intraperitoneal or intravenous vaccination with up to 10 ImD 50 of vaccine: the numbers of organisms increased for 3 days and then declined. Injection of about four ImD 50 of vaccine intracerebrally produced a local immunity, resulting in an immediate kill of challenge organisms given 14 days later. Such an effect following intraperitoneal vaccination was achieved only against challenges with an avirulent strain. It is suggested that better stimulation of circulating antibody and local immunity in the brain together account for the better protection induced by intracerebral vaccine.Immunity to an intracerebral infection appears therefore to have at least three components, each specific for pertussis. The first, like that induced by intraperitoneal and intravenous vaccination, reaches a maximum in 2 or 3 weeks and is probably an expression of a general response by the animal operating not earlier than 3 days after infection. The second is a local immunity, appearing after the same interval. The third is a short-lived local immunity which has been described by previous workers; it immediately follows the injection intracerebrally of ten times less vaccine than that needed to protect against a challenge 14 days later and lasts only 2-3 days. The second and third types result in immediate sterilization of the infection.Mice recovering from sublethal brain infection with avirulent organisms were immune to a second infection with a virulent organism, but this was achieved not by the ability to kill the re-infecting organisms immediately on injection into the brain, but only after the 3-4 days lag such as follows intraperitoneal vaccination. PMID- 4342000 TI - The effects of spraying on the amounts of airborne foot-and-mouth disease virus present in loose-boxes. AB - The air of loose-boxes which had previously held pigs infected with foot-and mouth disease was sampled for virus after various procedures. Removal of infected pigs led to a 12- to 16-fold reduction in the amount of virus after 5 min. and a 400-fold reduction after 60 min. After heavy spraying (1.2 mm. of water in 5 min.) the amount of virus was reduced 500-fold compared to 30-fold after light spraying (0.20 mm. of water in 5 min.). The partition of infectivity associated with particle size was measured. The partition found after light spraying was similar to that found 5 min. after the pigs had been removed. Heavy spraying brought about a reduction in the infectivity associated with the large particles (> 6 mum.) but had no effect on particles less than 3 mum. A similar partition was found 60 min. after the pigs had been removed. The findings are discussed in relation to the spread of foot-and-mouth disease by the airborne route. PMID- 4342001 TI - Observations on procedures for thawing and spit-roasting frozen dressed chickens, and post-cooking care and storage: with particular reference to food-poisoning bacteria. AB - A comparison was made of four methods of thawing frozen chickens and an average thaw time for each method was determined.Fully and partially thawed chickens, inoculated with salmonellas, Clostridium welchii and Staphylococcus aureus were cooked in a spit-roasting oven at different temperatures for different lengths of time. The chickens were examined freshly cooked and after storage under various conditions.Spit roasting fully thawed chickens until the outer skin was golden brown was sufficient heat-treatment to kill salmonellas and Staph. aureus but Cl. welchii could survive. Salmonellas could also survive if the chickens were not fully thawed before cooking.Incorrect storage after cooking was shown to encourage the growth of pathogens.The incidence of intestinal pathogens in frozen dressed chickens and environmental hazards in spit-roasting establishments were also studied. Of raw chickens examined 35% contained salmonellas (9 serotypes), 63% contained Cl. welchii and 63% Staph. aureus. PMID- 4342003 TI - The effects of deprivation of rapid eye movement (REM) sleep on maze learning and aggression in the albino rat. PMID- 4342004 TI - Studies of periodic catatonia. 3. Longitudinal sleep study with urinary excretion of catecholamines. PMID- 4342002 TI - The effect of adenosine on the release of the transmitter from the phrenic nerve of the rat. AB - 1. The action of adenosine on neuromuscular transmission has been studied on the rat phrenic nerve-diaphragm preparation.2. Adenosine (0.025-10 mM) reversibly reduced the quantum content of end-plate potentials and the frequency of miniature end-plate potentials to about half the control values in preparations in which transmission was blocked with high Mg(2+) and/or low Ca(2+) concentrations. Where transmission was blocked with tubocurarine, the amplitude of end-plate potentials was reduced to about half the control values by adenosine.3. In solutions with very low Ca(2+) concentrations (no added Ca(2+) and 1 mM-EGTA) adenosine had a smaller effect on the frequency of miniature end plate potentials.4. The effect of adenosine (0.025 and 0.05 mM) was abolished by theophylline (1.8 mM).5. The results are discussed in relation to the increase in cyclic AMP in brain slices caused by adenosine and the abolition of this effect by theophylline (Sattin & Rall, 1970). PMID- 4342005 TI - [Postlymphographic febrile reactions in malignant reticulopathies]. PMID- 4342006 TI - [Premedication in the prevention of complications due to iodized contrast media: iodine intolerance should not be a contraindication to intravenous urography]. PMID- 4342007 TI - [Multilocular cyst of the kidney in children. A case]. PMID- 4342008 TI - [Para-sleep and skin action potentials]. PMID- 4342009 TI - Respiratory activity and cytochrome content of liver mitochondria from diabetic rats. PMID- 4342010 TI - Classical maple syrup urine disease: cofactor resistance. PMID- 4342011 TI - Gluconeogenesis. PMID- 4342012 TI - [A further case of melanotic progonoma]. PMID- 4342013 TI - A comparison of the effect of induction of anaesthesia by thiopentone or Althesin on the duration of action of suxamethonium. PMID- 4342014 TI - [Pain as seen by a neurosurgeon]. PMID- 4342015 TI - [Treatment of trophoblastic tumors]. PMID- 4342017 TI - The rat ovarian augmentation method for follicle stimulating hormone. Specificity of the test. PMID- 4342016 TI - [Value of scintigraphy in the diagnosis of infratentorial tumors]. PMID- 4342018 TI - Perfusion of the isolated human uterus. PMID- 4342019 TI - Malignant trophoblastic neoplasia. Monitoring of therapy. PMID- 4342020 TI - On the pharmacology of cortical evoked potentials. PMID- 4342022 TI - A requirement for cytochrome b 5 in microsomal stearyl coenzyme A desaturation. PMID- 4342021 TI - Electrophoretic study of the polypeptides from surface membranes of mammalian cells. PMID- 4342023 TI - Carbon monoxide as a probe for conformation changes of ferrocytochrome c. PMID- 4342024 TI - Spin-label-induced nuclear relaxation. Distances between bound saccharides, histidine-15, and tryptophan-123 on lysozyme in solution. PMID- 4342025 TI - Isoleucyl transfer ribonucleic acid synthetase of Escherichia coli B. A rapid kinetic investigation of the L-isoleucine-activating reaction. PMID- 4342026 TI - Reaction of glyceraldehyde-3-phosphate dehydrogenase with dibromoacetone. PMID- 4342027 TI - Structure of rat skin collagen alpha 1-CBB. Amino acid sequence of the hydroxyl amine-produced fragment HA2. PMID- 4342028 TI - Studies of the interaction of 5-hydroxytryptamine and the perivascular innervation of the guinea-pig caecum. AB - 1. The action and interaction of noradrenaline (NA), 5-hydroxytryptamine (5-HT) and the sympathetic innervation was studied in the isolated taenia of the guinea pig caecum.2. Addition of 5-HT led to a contraction of the taenia while addition of NA or perivascular nerve stimulation resulted in relaxation. Responses to 5-HT or perivascular nerve stimulation were abolished by tetrodotoxin. Tetrodotoxin did not affect responses to applied NA. Hexamethonium and hyoscine converted the 5-HT response to a relaxation and augmented the relaxation which followed low frequency perivascular nerve stimulation. Hexamethonium and hyoscine did not affect the dose-response relationship for NA.3. Fatigue of mechanical responses of the taenia to perivascular nerve stimulation was accelerated when nerves were stimulated in the presence of 5-HT or alpha-methyl-p-tyrosine (alpha-MPT). These two agents were additive in this action.4. Reserpine, 6-hydroxydopamine and alpha MPT all reduced the NA content of the taenia. However, only after 6 hydroxydopamine could adrenergic activity be related to NA content.5. Segments of taenia were incubated with either tritiated NA or 5-HT. An increased rate of release of radioactivity followed perivascular nerve stimulation after incubation with either substance. This release did not occur when tissue was taken from animals given reserpine or 6-hydroxydopamine.6. It is concluded that 5-HT activates neural elements exclusively while NA has a direct effect on smooth muscle. 5-HT can apparently be taken up by adrenergic axons, and appears to enter the releasable neurotransmitter pool. Since none of the actions characteristic of 5-HT are seen when it is released by adrenergic axons as a false neurotransmitter, the released amine probably fails to reach neuronal receptors for 5-HT. PMID- 4342030 TI - Manic-depressive psychosis and urinary excretion of cyclic AMP. PMID- 4342029 TI - The action of bombesin on the systemic arterial blood pressure of some experimental animals. AB - 1. The changes in blood pressure in response to parenteral administration of bombesin, the active tetradecapeptide of the skin of the European discoglossid frogs Bombina bombina and Bombina variegata variegata have been investigated in some experimental animals.2. In most species, the polypeptide elicited hypertension which was usually gradual in onset and slow to disappear. Blood pressure increases rarely exceeded 40-50 mmHg. At the beginning of an experiment some dose-response relationship could often be observed, but later tachyphylaxis developed. During an intravenous infusion of bombesin the rise in blood pressure could sometimes be maintained at a steady level as long as the infusion was continued, but at other times, the rise of pressure slowly subsided with continued administration of the polypeptide. In the rat and the chicken hypertension elicited by high doses of bombesin was often followed by secondary hypotension.3. Bombesin-induced hypertension was apparently not affected by pretreatment with either alpha- or beta-adrenergic blocking agents. Similarly secondary hypotension was not abolished by atropine. Thus, the effect of bombesin on vascular smooth muscle seems to be predominantly a direct one.4. Angiotensin was usually more potent than bombesin, and its effect on blood pressure was more rapid and of shorter duration. Tachyphylaxis to angiotensin was lacking or moderate.5. In sharp contrast to the other species, the monkey responded to bombesin with frank hypotension, which was usually proportional to the dose. In the monkey the hypotensive effect of bombesin was equal to, or greater than that of eledoisin or physalaemin and bombesin-induced hypotension was of longer duration than that of the other polypeptides. Tachyphylaxis was moderate for low and adequately spaced doses of the polypeptide, but prompt and intense for high doses. Long-lasting hypotension was obtained by intravenous infusion of bombesin, but repeated infusions caused tachyphylaxis. Bombesin-induced hypotension was not affected by pretreatment with atropine.6. Bombesin may be easily distinguished from all other known peptides active on vascular and extravascular smooth muscle by its effects on blood pressure. This does not apply to bombesin-like peptides, such as alytesin and ranatensin. PMID- 4342031 TI - Biochemical and structural changes in mitochondria and other cellular components of pea cotyledons during germination. PMID- 4342032 TI - In vitro stimulation of human lymphocytes by Epstein-Barr virus. PMID- 4342033 TI - Quantum description of synaptic nervous function. The phenomenological status of the conditional reflex. PMID- 4342034 TI - The epitaxy of poly-L-alanine on L-quartz and a glass-ceramic. PMID- 4342035 TI - Biocompatibility of ceramic implants in soft tissue. PMID- 4342036 TI - Dissociation of in vivo and in vitro "autonomy" in hyperfunctioning thyroid nodules. PMID- 4342037 TI - Gonadal steroid effects on plasma lipoproteins and individual phospholipids. PMID- 4342038 TI - Plasma proinsulin in patients with functioning pancreatic islet cell tumors. PMID- 4342039 TI - 11-beta-hydrosylase deficiency: steroid response to sodium restriction and ACTH stimulation. PMID- 4342040 TI - Biochemical changes during mixed infections with bacteriophages T2 and T4. PMID- 4342041 TI - Defective mouse sarcoma virus deficient in DNA polymerase activity. PMID- 4342042 TI - Haemolysis by Sendai virus: lack of requirement for neuraminidase. PMID- 4342043 TI - Effects of therapeutic agents on cyclic AMP metabolism in vitro. PMID- 4342045 TI - Role of drug metabolism in drug research and development: factors affecting metabolism of drugs and their pharmacological and toxicological activity. PMID- 4342044 TI - Measurement of beta-lactamase activity and rate of inactivation of penicillins by a pH-stat alkalimetric titration method. PMID- 4342046 TI - Polyoma pseudovirions. I. Sequence of events in primary mouse embryo cells leading to pseudovirus production. AB - The relationship of the intracellular events leading to the production of polyoma pseudovirions in primary mouse embryo cells has been investigated. Replication of polyoma deoxyribonucleic acid (DNA) began 18 hr after infection. Assembly of viral capsid protein occurred 12 hr later. Intracellular fragments of host cell DNA, of the size found in pseudovirions, were first detected 36 hr after infection. The amount of intracellular 14S host DNA that was produced during infection was seven times greater than the amount of polyoma DNA synthesized. The relative pool sizes of polyoma DNA and 14S DNA at the time of virus assembly may dictate the amounts of polyoma virus and pseudovirus produced. PMID- 4342047 TI - Capsid polypeptides of mouse Elberfeld virus. I. Amino acid compositions and molar ratios in the virion. AB - The four major polypeptide chains (alpha, beta, gamma, delta) constituting the capsid protein of mouse Elberfeld (ME) virus were isolated by preparative electrophoresis on polyacrylamide gels, and the amino acid composition of each chain was determined. In addition, the molecular weights of the smallest chains of ME virus, mengovirus, and poliovirus, which had previously been determined by gel electrophoretic methods, were redetermined by gel filtration chromatography in 6 m guanidine hydrochloride. Each was found to have a molecular weight about 7,300. Using the reevaluated molecular weights and the known amino acid compositions of the chains, the molar ratio of each chain in the ME virion was determined by quantitative analysis of the distribution of radioactivity in the electrophoretically separated chains of virus which had been specifically radiolabeled with leucine or with methionine. Equimolar proportions of all four chains were found in the virion. PMID- 4342048 TI - Demonstration of infectious deoxyribonucleic acid in transformed cells. I. Recovery of simian virus 40 from yielder and nonyielder transformed cells. AB - Deoxyribonucleic acid (DNA) was extracted from virus-free simian virus 40 (SV40) transformed hamster, mouse, and monkey cells and was inoculated into simian cells in the presence of diethylaminoethyl (DEAE)-dextran; infectious SV40 was recovered by using DNA from cell lines which fail to yield virus by the fusion technique as well as from cell lines which readily yield virus by fusion. The rescued virus was identified as SV40 by three methods: (i) neutralization of plaque formation by specific antiserum; (ii) induction of synthesis of viral specific antigens detected by immunofluorescence; and (iii) presence of papovavirus particles seen by the electron microscope. Treatment of the transformed cell DNA with deoxyribonuclease or omission of the DEAE-dextran prevented the rescue of virus. Large amounts of transformed cell DNA were required (>10 mug/culture of 10(6) cells) to effect rescue of SV40 by passage through monkey cells. A linear response was obtained between the input of DNA with inocula between 10 and 45 mug of DNA/culture and the yield of SV40 recovered. Biological activity was demonstrable irregularly when the transformed cell DNA was assayed directly in the presence of DEAE-dextran. The DNA induced plaque formation in about 50% of the trials as well as the synthesis of SV40 tumor and viral antigens in rare simian cells. The infectious DNA appeared to be associated with cellular DNA. The infectivity was found in the pellet of precipitated DNA obtained by the Hirt technique and was inactivated by boiling for 15 min. These properties are characteristic of linear cellular DNA and not of free, circular SV40 DNA. PMID- 4342049 TI - Characterization of an endonuclease associated with simian virus 40 virions. AB - An endonucleolytic activity associated with purified simian virus 40 (SV40) virions has been found. The enzyme is present in virions prepared from a number of different host lines. The enzyme is present in all early and late temperature sensitive mutants examined. Some aspects of the endonucleolytic activity have been examined with SV40 deoxyribonucleic acid as substrate. PMID- 4342050 TI - Fate of infecting simian virus 40-deoxyribonucleic acid in nonpermissive cells: integration into host deoxyribonucleic acid. AB - Nonpermissive 3T3 cells were infected with purified superhelical simian virus 40 (SV40) deoxyribonucleic acid I (DNA I). One hour after infection, approximately 60% of the intracellular SV40 DNA was converted to relaxed forms. One day after infection, all intracellular SV40 DNA was present as slow-sedimenting material, and no SV40 DNA I was detectable. At 2 days after infection there appeared viral DNA sequences cosedimenting with cellular DNA during alkaline velocity centrifugation. Furthermore, by both alkaline equilibrium gradient centrifugation and by DNA-ribonucleic acid hybridization analysis, covalent linkage of viral DNA sequences to cellular DNA was demonstrated. Integration of SV40 DNA into cellular DNA did not appear to require DNA synthesis, although DNA synthesis followed by mitotic division of the cells enhanced the amount of viral DNA integrated. Based on data obtained by two different methods, it was calculated that 1,100 to 1,200 SV40 DNA equivalents must be integrated per cell by 48 hr after infection. PMID- 4342051 TI - Fatty chains of different lipid classes of Semliki forest virus and host cell membranes. AB - Semliki Forest virus was grown in BHK-21 cells. The major classes of phospho-and glycolipids of the virus were analyzed for the compositions of fatty acids, aldehydes, and sphingosine bases, and the major glycerophospholipids were analyzed for the relative proportions of alkenyl-acyl, alkyl-acyl, and diacyl forms. All viral lipid classes proved to be mixtures of several molecular species. Each class contained a characteristic mixture of fatty chains, which was different in all other classes. All viral lipid classes resembled their counterparts of the host plasma membrane and also those of the endoplasmic reticulum. The gangliosides of the virus and the plasma membrane proved to be similar even at the level of individual molecular species. The number of certain lipid molecules in an average virion was less than the number of the protein molecules. PMID- 4342052 TI - Immunological studies on viral polypeptide synthesis in cells replicating murine sarcoma-leukemia virus. AB - Antibodies to disrupted murine sarcoma-leukemia virus (MSV[MLV]) were used to study the synthesis of viral polypeptides in the transformed, virus-producing rat cell line 78A1. When cultures were labeled for 10 min with radioactive amino acids, about 9% of the total labeled proteins were precipitated with antiserum against purified MSV(MLV), and 3 to 4% were precipitated with the same antiserum after it had been absorbed with an extract from uninfected rat cells. The difference is due to the presence in the unabsorbed antiserum of antibodies to cellular proteins that are present in purified virus preparations. Intracellular viral proteins labeled with radioactive amino acids were isolated by immunoprecipitation and analyzed by electrophoresis in sodium dodecyl sulfate polyacrylamide gels. The mobilities of intracellular viral polypeptides were identical to those of the purified virion. However, labeled polypeptides having electrophoretic mobilities lower than that of the major virion polypeptide, the group-specific antigen of molecular weight 31,000, were present in higher proportion in the total cell extract and in the membrane fraction than in the virion. These polypeptides appear to be of cellular origin for they were present only in minute amounts in the immunoprecipitates obtained with the absorbed serum. After a 10-min labeling period, radioactive proteins were assembled into extracellular virions rapidly for the first 4 hr followed by a slower rate. More than 2% of the total proteins of the cell labeled in a 10-min pulse were assembled into virions at the completion of a 24-hr chase. The high-molecular weight polypeptides with the same mobilities as those detected in the immunoprecipitate of intracellular proteins were found in virions released from cells after a 10-min pulse. A larger proportion of these high-molecular-weight proteins was detected in virions released after short chase periods (30-120 min) than after longer chase periods (6-24 hr). Two possible interpretations of these data are that the high-molecular-weight cell-derived polypeptides (i) have a turnover rate higher than that of the major virion polypeptides or (ii) are cleaved proteolytically from the virions during long incubation in the culture media. PMID- 4342053 TI - Virus deoxyribonucleic acid sequences in subdiploid and subtetraploid revertants of polyoma-transformed cells. AB - Polyoma-transformed cells can revert in the properties characteristic of transformation, although they maintain the polyoma-specific T antigen. Transformed cells contain the same number of copies of polyoma virus deoxyribonucleic acid (DNA) per cell (eight) as revertants with a subdiploid or a subtetraploid chromosome number. The results indicate that the duplication of chromosomes in the subtetraploid revertants did not include the chromosomes that carry the viral genome. The virus DNA in both transformed and revertant cells was associated with high-molecular-weight cell DNA. Reversion of the properties of transformed cells was, therefore, not associated either with a decrease in number of virus DNA copies per cell or with a lack of association of the virus DNA with cell DNA. PMID- 4342054 TI - Specific initiation site for simian virus 40 deoxyribonucleic acid replication. AB - Replicating simian virus 40 (SV40) deoxyribonucleic acid (DNA) molecules have been isolated under conditions in which the newly synthesized DNA is uniformly labeled with (3)H-thymidine. These newly synthesized strands are released from the replicative intermediate molecules by alkaline treatment, and it has been possible to isolate single-stranded SV40 DNA which varies in size from 157,000 daltons (from molecules that are 10% replicated) to 1,360,000 daltons (85% replicated). The rates of duplex formation of newly synthesized DNA have been used to relate their genetic complexity to the extent of DNA replication. As DNA replication proceeds, the time required to effect 50% renaturation of the newly synthesized DNA increases at a proportional rate. The data establish that DNA replication is not initiated at random, but rather that there is a single specific initiation site for DNA replication. PMID- 4342055 TI - Origin and direction of simian virus 40 deoxyribonucleic acid replication. AB - Double-branched, circular, replicating deoxyribonucleic acid (DNA) molecules of simian virus 40 (SV40) have been cleaved by the R(1) restriction endonuclease from Escherichia coli. This enzyme introduces one double-strand break in SV40 DNA, at a specific site. The site of cleavage in the replicating molecules was used in this study to position the origin and the two branch points. Radioactively labeled molecules fractionated according to their extent of replication were evaluated after cleavage by sedimentation analysis and electron microscopy. The results demonstrate that the R(1) cleavage site is 33% of the genome length from the origin of replication and that both branch points are growing points. These data indicate that SV40 DNA replication is bidirectional and confirm other reports which have shown a unique origin of replication. PMID- 4342056 TI - Membrane-associated replication complex in arbovirus infection. AB - Cytoplasmic extracts of chicken embryo fibroblast cells infected with Semliki Forest virus were subjected to isopycnic centrifugation in discontinuous sucrose gradients. Seven distinct bands were usually formed. The four upper bands contained predominantly smooth membranes and the lowest band was enriched in rough endoplasmic reticulum. One fraction (fraction 5), banding at a density of 1.16 g/cm(3), was found to be heavily enriched in pulse-labeled ribonucleic acid (RNA), viral RNA polymerase, and viral RNA forms associated with RNA replication. Thus, fraction 5 evidently contained a membrane-associated viral replication complex of a type previously defined in picornavirus infections. Fraction 5 was also consistently enriched with unique membranous structures previously observed in intact cells as type 1 cytopathic vacuoles (CPV-1). When the CPV-1 in fraction 5 were isolated from cells briefly incubated with (3)H-uridine and (3)H-adenosine prior to cell disruption, a large proportion was found to be labeled by high resolution autoradiography. Thus, ultrastructural, biochemical, and biological evidence were all consistent with the interpretation that the CPV-1 membranes represent a significant element of the viral replication complex. PMID- 4342058 TI - [Studies on hypertension accompanying renal failure: plasma renin activity and plasma angiotensinase activity in renal failure]. PMID- 4342057 TI - Transfer ribonucleic acid nucleotidyltransferase and transfer ribonucleic acid in Sendai virions. AB - Sendai virions contain both transfer ribonucleic acid (tRNA) nucleotidyltransferase and its substrate, tRNA missing its CCA-OH end. PMID- 4342059 TI - [Pressor effect of angiotensins I and II in rats immunized against both polypeptides]. PMID- 4342060 TI - Enzyme-kinetics of the renin-angiotensin system. PMID- 4342061 TI - Renin and angiotensin in extra-renal tissues. PMID- 4342062 TI - Some relations connecting angiotensin, catecholamines and hypertension. PMID- 4342064 TI - Angiotensin, hypertension and vascular ionic composition. PMID- 4342063 TI - [Mode of action of angiotensin on smooth muscle: observations on analogous alkylating agents]. PMID- 4342065 TI - Effects of renin and angiotensin on water intake. PMID- 4342067 TI - [Hemodynamic effects of angiotensin]. PMID- 4342066 TI - A possible role of angiotensin in the regulation of glomerulotubular balance for sodium. PMID- 4342068 TI - [The renin-angiotensin system in acute renal failure]. PMID- 4342069 TI - Peptidic inhibitors of the angiotensin-converting enzyme. PMID- 4342070 TI - [Electron microscopic study of RNA-type inclusions in skeletal muscle in dermatomyositis]. PMID- 4342071 TI - On the relationship between bluetongue, African horsesickness and reoviruses: hybridization studies. PMID- 4342072 TI - [Histochemical changes in the liver of rats under the influence of prolonged administration of amphetamine]. PMID- 4342073 TI - Erythropoietin: pharmacology, biogenesis and control of production. PMID- 4342074 TI - Experimental swinepox in gnotobiotic piglets. PMID- 4342076 TI - [Methods of contrasting the lymph nodes of the mediastinum (experimental study)]. PMID- 4342075 TI - Observations on the alkaline phosphatase content of the neutrophil granulocytes of some laboratory and farm animals, with particular reference to the effects of intensive management and reproduction. PMID- 4342077 TI - The role of respiratory viruses in equine disease. PMID- 4342078 TI - Artificial assembly of envelope particles of HVJ (Sendai virus). I. Assembly of hemolytic and fusion factors from envelopes solubilized by Nonidet P40. PMID- 4342079 TI - Artificial assembly of envelope particles of HVJ (Sendai virus). II. Lipid components for formation of the active hemolysin. PMID- 4342080 TI - Polyoma T antigen synthesis by temperature-sensitive mutants of polyoma virus. PMID- 4342081 TI - Electrophoresis of thymidine kinase activity synthesized by cells transformed by herpes simplex virus. PMID- 4342082 TI - Replication of vesicular stomatitis virus. II. Separation and characterization of virus-specific RNA species. PMID- 4342083 TI - Herpesvirus replication in vivo. PMID- 4342084 TI - Correlation between murine sarcoma virus buoyant density, infectivity, and viral RNA electrophoretic mobility. PMID- 4342086 TI - Liver involvement in cholecystitis and in obstructive icterus. A study with special reference to hexobarbital metabolism and glucose-6-phosphatase activity of human liver microsomes. PMID- 4342085 TI - Experimental gliomas cultured in vitro. Morphological and histochemical study. PMID- 4342087 TI - Discovery of psammoma bodies and fungus organisms in the nipple secretion with improved breast cytology technique. PMID- 4342088 TI - Herpes genitalis virus isolation from human bladder urine. PMID- 4342090 TI - The cytology of sputum from thermally injured patients. PMID- 4342089 TI - Identification of trophozoite form of Entamoeba histolytica by cytologic techniques. PMID- 4342091 TI - Lipofuscin granules in the cytoplasm of exfoliated epithelial cells in urine from cows. PMID- 4342092 TI - The significance of cellular atypia in the diagnosis of malignancy in ulcers of the female genital tract. PMID- 4342093 TI - Results of adrenal and pituitary stimulation tests in patients with multiple sclerosis. PMID- 4342094 TI - Effective transmitter concentrations in the rat portal vein as reflected by neurogenic potentiation of responses to exogenous noradrenaline. PMID- 4342095 TI - Role of cyclic AMP and Ca ++ in the metabolic and relaxing effects of catecholamines in intestinal smooth muscle. PMID- 4342096 TI - Centrally mediated effects of sodium and angiotensin II on arterial blood pressure and fluid balance. PMID- 4342097 TI - Vagal and sympathetic efferent discharge in the Bainbridge reflex of dogs. PMID- 4342098 TI - Plasma glycosphingolipids in lipid disorders. PMID- 4342099 TI - Enzyme defects in the sphingolipidoses and their application to diagnosis. PMID- 4342100 TI - Lipoprotein fractionation by column chromatography. PMID- 4342101 TI - Diet and drug treatment of hyperlipidemia and atherosclerosis. PMID- 4342102 TI - Effect of sucrose and uncouplers on lipid spin labeling of mitochondria. PMID- 4342103 TI - Fructose 1,6-diphosphatase from Rhodopseudomonas palustris. II. Regulatory properties. PMID- 4342104 TI - Bacteriophage phi 80-induced low molecular weight RNA. PMID- 4342105 TI - Effect of transfer ribonucleic acid on the rate law and mechanism of the adenosine triphosphate--pyrophosphate isotope exchange reaction of an aminoacyl transfer ribonucleic acid synthetase. PMID- 4342106 TI - Hepatic carbamyl phosphate: glucose phosphotransferase. Distribution, comparative kinetics, and responses to alloxan- or mannoheptulose-induced diabetes. PMID- 4342107 TI - A comparison of microbody membranes with microsomes and mitochondria from plant and animal tissue. PMID- 4342108 TI - Fructose 1,6-diphosphatase from Rhodopseudomonas palustris. I. Purification and properties. PMID- 4342109 TI - Partial purification and characterization of peptidyl proline hydroxylase precursor from mouse fibroblasts. PMID- 4342110 TI - On the mechanism of alkaline and neutral fructose 1, 6-diphosphatase: inhibition by substrate analogs at neutral pH. PMID- 4342111 TI - The effect of ascorbic acid on collagen polypeptide synthesis and proline hydroxylation during the growth of cultured fibroblasts. PMID- 4342112 TI - Stoichiometric trapping of a convalent phosphoryl-enzyme intermediate occurring in reactions catalyzed by an acid phosphatase. PMID- 4342113 TI - Contribution of "substrate shuttles" in the transport of extramitochondrial reducing equivalents by hepatic mitochondria from chronic alcohol-fed mice. PMID- 4342115 TI - The oxidation of L-lactate by liver mitochondria. PMID- 4342114 TI - Properties of uridine diphosphoglucose dehydrogenase from pollen of Lilium longiflorum. PMID- 4342116 TI - Group vs individual psychotherapy with schizophrenics. A controlled outcome study. PMID- 4342117 TI - Premorbid adjustment, phenothiazine treatment, and remission in acute schizophrenics. PMID- 4342119 TI - A polygraphic study of sleep in the tree shrew (Tupaia glis). PMID- 4342118 TI - Acid phosphatase localization during differentiation in the cellular slime mold Dictyostelium discoideum. PMID- 4342120 TI - An aberration of glucose metabolism and steroidogenesis in adrenals of thiamin deficient rats. PMID- 4342123 TI - Interaction of testosterone and ACTH in the regulation of adrenal corticosterone secretion in the male rat. PMID- 4342121 TI - Adrenal cells in tissue culture. IX. The site of ACTH stimulation of glucose metabolism. PMID- 4342122 TI - 2-Ketoglutarate oxidation by isolated rat epididymal adipose tissue and fat cells. Effects of hormones that stimulate fat cell adenylate cyclase. PMID- 4342125 TI - Several adenosine 3',5'-monophosphate-dependent protein kinases in the thyroid. PMID- 4342124 TI - Cyclic nucleotide-dependent protein kinase in the thyroid: partial purification and characterization. PMID- 4342126 TI - Ultrastructural changes accompanying the stimulatory effect of N6-monobutyryl adenosine 3',5'-monophosphate on the release of growth hormone(GH), prolactin (PRL) and adrenocorticotropic hormone (ACTH) in rat anterior pituitary gland in vitro. PMID- 4342127 TI - Chronic toxicity and carcinogenicity in mice of the purified mycotoxins, luteoskyrin and cyclochlorotine. PMID- 4342128 TI - Lymphocytic sarcoma of the mouse associated with virus-like particles. PMID- 4342130 TI - Radiosensitivity of islet-forming ascites tumors of rat. PMID- 4342129 TI - Spontaneous tumors in hamsters: incidence, morphology, transplantation, and virus studies. PMID- 4342131 TI - Dual infection of a human lymphoblastoid cell line with Epstein-Barr virus and Rauscher leukemia virus. PMID- 4342132 TI - [Chemodectoma mediastini (paraganglioma nonchromaffinicum mediastini)]. PMID- 4342133 TI - Chicken antibodies to soluble rat collagen. I. Characterization of the immune response by precipitation and agglutination methods. PMID- 4342134 TI - Preparation and properties of some benzotropylium perchlorates. PMID- 4342136 TI - [Photodensitometric in situ determination of Secale cornutum alkaloids]. PMID- 4342135 TI - [Orthotopic transplantation of the liver in the dog. Report of 50 cases. Trial of an antilymphocyte serum]. PMID- 4342137 TI - The excretion of oestrogen conjugates in late pregnancy urine. PMID- 4342139 TI - [Endoscopic diagnosis of the esophageal and gastric cancer]. PMID- 4342138 TI - Conjugation of 2-hydroxyoestrone in rat bile. PMID- 4342140 TI - [Elements of neuromuscular electrodiagnosis. Chronaximetry and intensity-duration curves; clinical electromyography; conduction rate of the motoneural fibers; electroneurography]. PMID- 4342141 TI - [Case of mixed laryngeal tumor]. PMID- 4342142 TI - Prolonged apnea and the sudden infant death syndrome: clinical and laboratory observations. PMID- 4342143 TI - Alcohol and sleep in young adults. PMID- 4342144 TI - [Pelvic myopathy caused by hypercorticism. Discovery of a pancreatic adenocarcinoma with corticotropic secretion]. PMID- 4342145 TI - [Urinary cortisol analysis in chronic hepatitis. In vitro test with H 3 cortisol]. PMID- 4342146 TI - [Experiences with pancreatic scintigraphy]. PMID- 4342147 TI - Cardiac mechanisms for regulating stroke volume during elevation of aortic blood pressure in dogs. PMID- 4342148 TI - Differentiation of a vesicular disease of pigs in Hong Kong from foot-and-mouth disease. PMID- 4342149 TI - [Foot and mouth disease induced by a vaccinal strain of the virus]. PMID- 4342150 TI - [Allergenic effect of florimycin]. PMID- 4342151 TI - [Intramitochondrial inclusions in malignant melanoma]. PMID- 4342152 TI - [Invasive tumor growth]. PMID- 4342153 TI - [Granular-cell myoblastoma of the breast]. PMID- 4342154 TI - [Intestinal cytomegaly in childhood: electron microscopy studies of in-vivo collected material]. PMID- 4342155 TI - [Liver cirrhosis and primary liver carcinoma developed on the site of giant-cell hepatitis in infancy]. PMID- 4342156 TI - Pitfalls in drip-infusion technique. A new device for automatic control of infusion rate. PMID- 4342157 TI - The effect of halothane on the neuromuscular blocking action of pancuronium (Pavulon). PMID- 4342159 TI - Adrenal response and side reactions after long-term corticosteroid therapy in bronchial asthma. PMID- 4342158 TI - [The influence of REM sleep deprivation on heart rate and respiration]. PMID- 4342161 TI - Studies on the potential role of secretin in the islet cell tumor diarrheogenic syndrome. PMID- 4342160 TI - Genetic aspects of the Z-E syndrome: prospective studies in two kindred; antral gastrin cell hyperplasia. PMID- 4342162 TI - Lactae dehydrogenase from an extremely thermophilic Bacillus. PMID- 4342163 TI - [Fine structure of crystalloid inclusions in the mitochondria of Porterioochromonas stipitata]. PMID- 4342165 TI - Glutamate biosynthesis in Clostridium pasteurianum and its significance in nitrogen metabolism. PMID- 4342164 TI - [Study of the distribution of lipiodol F 131 I introduced into the lymphatic vessels of the dog]. PMID- 4342167 TI - Utilization and metabolic effects of acetaldehyde and ethanol in the perfused rat liver. AB - 1. Removal of acetaldehyde and ethanol has been studied in perfused rat livers. 2. The maximum rate of ethanol oxidation was 2mumol/min per g of liver, which was less than the calculated capacity of the ethanol-oxidizing system. The lactate/pyruvate ratio of the medium increased with the rate of ethanol removal. At low ethanol concentrations most of the acetaldehyde formed was oxidized further, but at ethanol concentrations above 16mm about 60% of the acetaldehyde left the liver unmetabolized. 3. At lower concentrations the greater part of added acetaldehyde was oxidized, but above 5mm, 50-60% of that removed was recovered as ethanol. 4. When the reduction of acetaldehyde was blocked by pyrazole, removal was strongly diminished. There was no effect on the lactate/pyruvate ratio during oxidation of low concentrations of acetaldehyde, even in the presence of pyrazole, but at higher concentrations a gradual increase occurred. 5. The results indicate that during ethanol oxidation the ethanol/acetaldehyde pair is not in redox equilibrium with the lactate/pyruvate pair. Ethanol oxidation was abolished by addition of acetaldehyde. Under these conditions the lactate/pyruvate ratio was 1.5-1.8 times the ethanol/acetaldehyde ratio, indicating equilibration of the alcohol dehydrogenase and lactate dehydrogenase systems. 6. The results support the view that ultimately the rate of mitochondrial oxidation of NADH limits the removal of ethanol in the liver. PMID- 4342168 TI - Hypocalcemic myopathy. PMID- 4342166 TI - Can mitochondria and synaptosomes of guinea-pig brain synthesize phospholipids? AB - 1. The use of ;marker' enzymes for investigating the contamination by endoplasmic reticulum of mitochondrial and synaptosomal (nerve-ending) fractions isolated from guinea-pig brain was examined. NADPH-cytochrome c reductase appeared to be satisfactory. With the synaptosomal preparation there was a non-occluded enzymic activity believed to arise from contaminating microsomes and an occluded form released by detergent, which probably was derived from some type of intraterminal smooth endoplasmic reticulum. 2. Isolated brain mitochondria, both intact and osmotically shocked, could not synthesize more labelled phosphatidylcholine from CDP-[Me-(14)C]choline or phosphoryl[Me-(14)C]choline than could be accounted for by microsomal contamination. They could synthesize only phosphatidic acid and diphosphatidylglycerol from a [(32)P]P(i) precursor and not nitrogen-containing phosphoglycerides or phosphatidylinositol. 3. The synaptosomal outer membrane and the intraterminal mitochondria could not synthesize phosphatidylcholine from CDP [Me-(14)C]choline but the synaptic vesicles and probably the intraterminal ;endoplasmic reticulum' appeared to be capable of catalysing the incorporation of label from this substrate into their phospholipids. 4. Microsomal fractions and synaptosomes from guinea-pig brain could incorporate [Me-(14)C]choline into their phospholipids by a non-energy-requiring exchange process, which was catalysed by Ca(2+). Fractionation of the synaptosomes after such an exchange had taken place revealed that the label was predominantly in the intraterminal mitochondria and not associated with membranes containing NADPH-cytochrome c reductase. 5. On the intraperitoneal injection of [(32)P]P(i) into guinea pigs, incorporation of radioactivity into phosphatidylinositol and phosphatidic acid was much faster than into the nitrogen-containing phosphoglycerides. Mitochondria and microsomal fractions showed a roughly equivalent incorporation into individual phospholipids, and that into synaptosomes was appreciably less, whereas the phospholipids of myelin showed little (32)P incorporation up to 10h. PMID- 4342169 TI - [Influence of the corticotropic hormone (ACTH) on oxygen and glucose consumption in the thymus of white rats]. PMID- 4342170 TI - [Quaking mice: study of sleep and of epileptic seizures]. PMID- 4342171 TI - [Effects of LSD and methysergide on ponto-geniculo-occipital spikes]. PMID- 4342172 TI - [Collagenase and adamantoblast differentiation]. PMID- 4342173 TI - [Effect of an adrenergic beta-blocking agent on adrenaline-induced hyperglycemia in hypophysectomized dogs]. PMID- 4342174 TI - A spin label study of the influence of cholesterol on egg lecithin multibilayers. PMID- 4342176 TI - Studies of adenosine and dibutyryl adenosine 3',5'-monophosphoric acid on the isolated fat cell. PMID- 4342175 TI - The effect of chronic consumption of ethanol on the redox state of the rat liver. PMID- 4342177 TI - Pancreatic islet levels of citrate under conditions of stimulated and inhibited insulin release. PMID- 4342178 TI - The relationship of somatic cell hybridization to carcinogenesis. PMID- 4342179 TI - Indication of hypoxic areas in tumours from in vivo NADH fluorescence. PMID- 4342181 TI - Metabolic controls in precancerous liver. II. Loss of feedback control of cholesterol synthesis, measured repeatedly in vivo, during treatment with the carcinogens N-2-fluorenylacetamide and aflatoxin. PMID- 4342180 TI - Subcellular particles in tumors. V. Behavior of mitochondria of hepatoma HC and Morris hepatomas 7316A, 7794B and 16 in density-gradient centrifugation. PMID- 4342182 TI - Inhibition of NADH-linked respiration with the anti-cancer agent 4'-demethyl epipodophyllotoxin thenylidene glucoside (VM-26). PMID- 4342183 TI - Formation of anucleate and multinucleate cells in normal and SV 40 transformed WI-38 by cytochalasin B. PMID- 4342184 TI - Effect of inhibitors of microtubules and microfilaments on dog thyroid slices in vitro. PMID- 4342185 TI - Neurochemical control of Arbacia sperm motility. PMID- 4342186 TI - Nucleocytoplasmic exchange of macromolecules. PMID- 4342188 TI - The primary interaction of antibody to components of aspergilli. I. Immunologic and chemical characteristics of a nonprecipitating antigen. PMID- 4342187 TI - Hormone-sensitive lipolytic activity of the aorta of different age groups of rats. PMID- 4342190 TI - The inhibition mechanism of the cytochrome oxidase reaction. II. Classification of inhibitors based on their modes of action. PMID- 4342189 TI - Isolation and properties of a pyruvate dehydrogenase complex from the yeast Hansenula miso. PMID- 4342192 TI - Evidence for the presence of a latent form of collagenase in human rheumatoid synovial fluid. PMID- 4342191 TI - The inhibition mechanism of the cytochrome oxidase reaction. 3. Combined effects of inhibitors on cytochrome oxidase. PMID- 4342193 TI - Possible participation of cyclic AMP in the regulation of -aminolevulinic acid synthesis in rat liver. PMID- 4342194 TI - On the structure of human serum low density lipoprotein. PMID- 4342195 TI - Transcription of Simian virus 40. I. Separation of the strands of SV40 DNA and hybridization of the separated strands to RNA extracted from lytically infected and transformed cells. PMID- 4342196 TI - The regulatory effect of oestrogens on fetal growth. II. Uterine and placental blood flow in rabbits. PMID- 4342197 TI - [Presynaptic inhibition of segmental interneurons]. PMID- 4342198 TI - [An electrophysiologic study of the pathways in the middle cervical sympathetic ganglion of turtles]. PMID- 4342199 TI - [The effect of polarization of the horizontal cells of the pike retina on the distribution of electrical potentials in them]. PMID- 4342200 TI - A mixed germ cell-sex cord stroma tumor of the ovary in a normal female infant. PMID- 4342201 TI - A follow-up service--supplemented by domicillary visits. PMID- 4342203 TI - The effect of nematode parasitism on the retention of calcium and phosphorus by growing lambs. PMID- 4342202 TI - The role of insulin in the regulation of glucose metabolism. PMID- 4342204 TI - Effect of ionizing radiation on nuclear energy transduction in normal and neoplastic glia. A quantitative cytochemical investigation. PMID- 4342205 TI - The secretory, histologic and histochemical effects of acute and subchronic administration of atropine sulfate on the gastric mucosa of the rat. PMID- 4342207 TI - Stimulation by acetylcholine of phosphatidylinositol labelling. Subcellular distribution in rat cerebral-cortex slices. AB - 1. Rat cerebral-cortex slices were incubated with (32)P(i), acetylcholine and eserine for periods of 10min and 2h. The specific radioactivity of phosphatidylinositol was elevated during these treatments by 36 and 106% respectively. 2. The specific radioactivities of the phosphatidylinositol in different cell structures were determined after subcellular fractionation. They were highest in the nuclear, microsomal and synaptic-vesicle fractions and lowest in myelin, both in the controls and in the acetylcholine-treated slices. 3. The stimulated labelling of phosphatidylinositol was relatively evenly distributed: no subcellular fraction showed a stimulation markedly higher than that in the homogenate. 4. Studies of the distributions and activities of marker enzymes indicated that the subcellular fractionation achieved was similar to that with fresh tissue. 5. The results are discussed in relation to the previous report that the stimulation is observed throughout the neuronal cell-bodies and in relation to the hypothesis that the labelled phosphatidylinositol produced by stimulation is a component of an acetylcholine-receptor proteolipid localized in the synaptic junction. PMID- 4342208 TI - The fractionation of phosphatidylinositol into molecular species by thin-layer chromatography on silver nitrate-impregnated silica gel. AB - 1. Two methods for the fractionation of phosphatidylinositol into molecular species were developed. In addition to preserving the fatty acid moiety of the molecule, the first method preserves the phosphorus, and the second preserves both the phosphorus and inositol ring. 2. In the first method, phosphatidylinositol was oxidized with periodate and the products reacted with diazomethane. I.r. examination showed that the main product was identical with dimethylphosphatidic acid. Fractionation to molecular species was carried out on thin layers impregnated with silver nitrate. The fatty acid composition of the species was determined by gas-liquid chromatography, and their distribution in lamb liver phosphatidylinositol was studied by a method using [(3)H]methanol. 3. In the second method, phosphatidylinositol was acetylated under mild reaction conditions. The major product was the triacetylated derivative of this phospholipid. This was reacted with diazomethane and the methylated-triacetylated phosphatidylinositol was fractionated into molecular species on silver nitrate impregnated thin layers. Solvent mixtures containing acetone and distilled chloroform were found most suitable for this purpose. The fatty acid composition of the molecular species was determined by g.l.c., and their distribution in lamb liver phosphatidylinositol was studied by a method using [1-(14)C]acetic anhydride during the acetylation reaction. 4. Results from both methods agree fairly well. The most predominant species of lamb liver phosphatidylinositol is the monoenoic (60%) followed by the tetraenoic (17%). The di- and tri-enoic species existed as minor components. PMID- 4342206 TI - Cyclic AMP and gastric secretion. PMID- 4342209 TI - D-myoinositol 1:2-cyclic phosphate 2-phosphohydrolase. AB - 1. An enzyme in extracts of mammalian tissues catalyses the hydrolysis of d myoinositol 1:2-cyclic phosphate (an intermediary in the enzymic degradation of phosphatidylinositol) to produce d-myoinositol 1-phosphate. 2. The enantiomorph of the substrate is not attacked. 3. The pH optimum is about 8.1-8.3 and the reaction is stimulated by Mg(2+) ions. 4. Extracts from rat kidney cortex and medulla are very rich sources of the enzyme; brain, testis and small intestine contain intermediary activities, and other tissues contain very small amounts. PMID- 4342211 TI - Chemical compositions of elastins isolated from aortas and pulmonary tissues of humans of different ages. AB - 1. Elastins were isolated from the visceral pleuras and parenchymas of lungs of humans of different ages. 2. The elastin content of pleuras increased whereas that of parenchymas remained constant with increasing age. 3. The amino acid compositions and carbohydrate contents of elastins isolated from both pulmonary tissues changed in the same way with increasing age of the subjects. These changes were similar to those observed in elastins isolated from the aorta. 4. Similar glycoproteins were isolated from pleuras and aortas, and were more difficult to extract from the elastins of older subjects. Contamination with these glycoproteins was responsible for the changes in composition of elastin, as the age of the tissue from which it was extracted increased. 5. The amount of the cross-linking amino acids desmosine and isodesmosine was lower in elastins isolated from both aorta and pulmonary tissues of senile subjects than those from younger subjects. PMID- 4342210 TI - The effect of prostaglandins on ox pituitary content of adenosine 3':5'-cyclic monophosphate and the release of growth hormone. AB - 1. An assay, based on competition between adenosine 3':5'-cyclic monophosphate (cyclic AMP) and cyclic [(3)H]AMP for binding to a rabbit skeletal muscle protein, has been used to measure tissue contents of cyclic AMP. The assay has a sensitivity of 0.05pmol of cyclic AMP. Cyclic GMP and cyclic CMP have 0.5%, and cyclic IMP 6.5%, of the ability of cyclic AMP to displace cyclic [(3)H]AMP from binding protein; AMP, ADP and ATP have no effect. 2. By using this method, the cyclic AMP content of ox pituitary slices exposed to prostaglandin was determined; release of growth hormone was measured by radioimmunoassay. 3. Release of growth hormone was increased by 45min incubation in 1mum-prostaglandin E(2) in the absence of theophylline, or in 10nm-prostaglandin E(2), 0.1mum prostaglandin A(1) or 1mum-prostaglandin B(1) in the presence of 0.5mm theophylline. 4. Pituitary cyclic AMP content was increased by 10min incubation in 1mum-prostaglandin E(2) in the absence of theophylline, or in 0.1mum prostaglandin E(2) in the presence of 0.5mm-theophylline. 5. The maximum increase in cyclic AMP content was observed 10min, and significant changes in growth hormone release 30min, after introduction of prostaglandin E(2). 6. The increase in pituitary cyclic AMP content, but not in the rate of release of growth hormone, was observed in the absence of external Ca(2+). 7. The stimulation of release of growth hormone by prostaglandin was decreased by preincubation of tissue for 2h in colchicine (100mum) or cytochalasin B (10mug/ml). 8. These results support the suggestion that increased release of growth hormone after treatment with prostaglandin is the result of increased tissue cyclic AMP content, and possibly involves a microfilamentous or microtubular protein. PMID- 4342212 TI - Some properties of pyruvate and 2-oxoglutarate oxidation by blowfly flight-muscle mitochondria. AB - 1. High rates of state 3 pyruvate oxidation are dependent on high concentrations of inorganic phosphate and a predominance of ADP in the intramitochondrial pool of adenine nucleotides. The latter requirement is most marked at alkaline pH values, where ATP is profoundly inhibitory. 2. Addition of CaCl(2) during state 4, state 3 (Chance & Williams, 1955) or uncoupled pyruvate oxidation causes a marked inhibition in the rate of oxygen uptake when low concentrations of mitochondria are employed, but may lead to an enhancement of state 4 oxygen uptake when very high concentrations of mitochondria are used. 3. These properties are consistent with the kinetics of the NAD-linked isocitrate dehydrogenase (EC 1.1.1.41) from this tissue, which is activated by isocitrate, citrate, ADP, phosphate and H(+) ions, and inhibited by ATP, NADH and Ca(2+). 4. Studies of the redox state of NAD and cytochrome c show that addition of ADP during pyruvate oxidation causes a slight reduction, whereas addition during glycerol phosphate oxidation causes a ;classical' oxidation. Nevertheless, it is concluded that pyruvate oxidation is probably limited by the respiratory chain in state 4 and by the NAD-linked isocitrate dehydrogenase in state 3. 5. The oxidation of 2-oxoglutarate by swollen mitochondria is also stimulated by high concentrations of ADP and phosphate, and is not uncoupled by arsenate. PMID- 4342214 TI - Rat thymocyte phosphofructokinase: some kinetic properties compared with those of muscle phosphofructokinase. PMID- 4342215 TI - Specificity studies on human intestinal alkaline phosphatase. PMID- 4342213 TI - Phosphatase synthesis in Klebsiella (aerobacter) aerogenes growing in continuous culture. AB - 1. Phosphatase synthesis was studied in Klebsiella aerogenes grown in a wide range of continuous-culture systems. 2. Maximum acid phosphatase synthesis was associated with nutrient-limited, particularly carbohydrate-limited, growth at a relatively low rate, glucose-limited cells exhibiting the highest activity. Compared with glucose as the carbon-limiting growth material, other sugars not only altered the activity but also changed the pH-activity profile of the enzyme(s). 3. The affinity of the acid phosphatase in glucose-limited cells towards p-nitrophenyl phosphate (K(m) 0.25-0.43mm) was similar to that of staphylococcal acid phosphatase but was ten times greater than that of the Escherichia coli enzyme. 4. PO(4) (3-)-limitation derepressed alkaline phosphatase synthesis but the amounts of activity were largely independent of the carbon source used for growth. 5. The enzymes were further differentiated by the effect of adding inhibitors (F(-), PO(4) (3-)) and sugars to the reaction mixture during the assays. In particular, it was shown that adding glucose, but not other sugars, stimulated the rate of hydrolysis of p-nitrophenyl phosphate by the acid phosphatase in carbohydrate-limited cells at low pH values (<4.6) but inhibited it at high pH values (>4.6). Alkaline phosphatase activity was unaffected. 6. The function of phosphatases in general is discussed and possible mechanisms for the glucose effect are outlined. PMID- 4342216 TI - Phosphatase activities of chicken liver and duodenum: characteristics, levels during development, and hydrocortisone-induced changes. PMID- 4342217 TI - The zinc-stimulated acid and neutral p-nitrophenyl phosphatase activities of chick liver and duodenum. PMID- 4342219 TI - Optical and magnetic measurements of horseradish peroxidase. 3. Electron paramagnetic resonance studies at liquid-hydrogen and -helium temperatures. PMID- 4342218 TI - Adenosine 3',5'-cyclic phosphate phosphodiesterase from bovine thyroid: isolation and properties of a partially purified, soluble fraction. PMID- 4342220 TI - Separation of multiple molecular forms of cyclic adenosine-3',5'-monophosphate phosphodiesterase in rat cerebellum by polyacrylamide gel electrophoresis. PMID- 4342222 TI - 'Bound for Broadmoor'. PMID- 4342221 TI - The preparation and kinetics of immobilised penicillin amidase from Escherichia coli. PMID- 4342223 TI - Ultrastructural alterations of liver and spleen following acute lead administration in rats. PMID- 4342225 TI - [DNA content of precancerous conditions of the skin. A contribution on the question of the special nosological position of cutaneous precancerous conditions]. PMID- 4342224 TI - Intestinal epithelium brush border and microsome chemistry. II. Cholera exoenterotoxin and neuramindase effects. PMID- 4342226 TI - [Endogenous immunity and antibiotic therapy. Studies on the influence of host specific defense mechanism on the antimicrobial effect of chemotherapeutic drugs in vitro]. PMID- 4342228 TI - An enzymic study on bovine erythrocuprein. PMID- 4342227 TI - Endogenous peroxidase in the lacrimal gland of the rat and its differentiation against injected catalase and horseradish-peroxidase. PMID- 4342229 TI - Some properties of lysine-rich histones of normal and neoplastic tissues. PMID- 4342230 TI - Phosphodiesterase and nucleoside-phosphomonoesterase activities in B. subtilis during sporulation. PMID- 4342231 TI - Quantity and fatty acyl composition of the glycosphingolipids of Gaucher spleen. PMID- 4342232 TI - Ozone interaction with rodent lung: effect on sulfhydryls and sulfhydryl containing enzyme activities. PMID- 4342233 TI - ADP as the cause of reversible inhibition of platelet retention in glass-bead columns. PMID- 4342234 TI - Induction of neoplasms by viruses in marmoset monkeys. PMID- 4342235 TI - The flow of ions in learning and memory. PMID- 4342236 TI - Sensitivity of ribonucleic acid and deoxyribonucleic acid viruses to different species of interferon in cell cultures. AB - Although two deoxyribonucleic acid (DNA) viruses, pseudorabies (PsRV) and vaccinia, are as susceptible as a ribonucleic acid (RNA) virus, vesicular stomatitis (VSV), to interferon when tested in chicken or mouse cells, they are refractory to inhibition in interferon-treated primary rabbit kidney cells and in a continuous line (RK-13) of rabbit kidney cells. Superinfection with VSV of RK 13 cells first infected with PsRV completely blocks the replication of PsRV with no effect on VSV yield. When the same experiment is carried out in RK-13 cells pretreated with 1,000 units of interferon, VSV replication is inhibited, which permits PsRV to replicate normally. These findings demonstrate that in the same cell one virus (PsRV) can be refractory to interferon and a second virus (VSV) can be susceptible. These experiments show that rabbit kidney cell cultures are deficient in the synthesis of resistance factors active against the DNA viruses tested and raise the possibility that separate resistance factors may exist for RNA and DNA viruses. In the case of sequential infection of interferon-treated RK 13 cells with vaccinia and VSV, it was found that not only was vaccinia replication refractory to inhibition by interferon, but also that prior infection with vaccinia was able to partially reverse the effect of the inhibitor on the replication of the VSV used for superinfection. On the basis of these and other data it is postulated that a vaccinia virion component or a replication product of vaccinia virus, or both, enables VSV to escape the inhibiting action of interferoninduced resistance factors. PMID- 4342237 TI - Isolation and characterization of simian virus 40 ribonucleic acid. AB - Deoxyribonucleic acid-ribonucleic acid (RNA) hybridization in formamide was used to isolate simian virus 40-specific RNA. Early in the lytic cycle, a 19S viral RNA species was observed. Late in the lytic cycle, 16S and 19S viral species were found. The 16S and 19S species of viral RNA were localized in the cytoplasm. High molecular-weight heterogeneous RNA, containing viral sequences, was isolated from the nuclear fraction of infected cells late in the lytic cycle. This RNA may contain non-viral sequences linked to viral sequences. The formamide hybridization technique can be used to isolate intact late lytic viral RNA which is at least 99% pure. PMID- 4342238 TI - Virus-associated nucleases: location and properties of deoxyribonucleases and ribonucleases in purified frog virus 3. AB - At least three nuclease activities are associated with purified frog virus 3. These activities are endodeoxyribonuclease (pH 7.5, double-stranded [DS] and single-stranded [SS] deoxyribonucleic acid [DNA]); endodeoxyribonuclease (pH 5.0, DS and SS DNA); endoribonuclease (DS and SS ribonucleic acid [RNA], pH 7.5). These activities are not adsorbed to the surface of the virion but are within the viral capsid and require detergent disruption of virions to unmask enzyme activity. Only one activity, deoxyribonuclease (pH 5.0, SS and DS DNA) appears to be core-associated after detergent disruption of virions. The ribonuclease degrades poliovirus replicative-form RNA, reovirus native RNA, and poly(I) poly(C) to a product with a sedimentation coefficient of about 6S. Qbeta 6S DS RNA and 4S transfer RNA are not degraded. The ribonuclease appears to be a late function of the virus and is elicited in a soluble form as well as a virus associated form. PMID- 4342239 TI - Studies of the mechanism of enhancement of human adenovirus infection in monkey cells by simian virus 40. AB - The defect which prevents human adenovirus replication in monkey cells and the mechanism whereby this restriction is overcome by coinfection with simian virus 40 (SV40) have been studied. Adenovirus capsid proteins are not synthesized efficiently in monkey cells in the absence of SV40. Adenovirus "enhancement" by SV40 was found to be the product of increased efficiency of replication by a small percentage of cells. This enhancement effect apparently occurred only when SV40 and adenovirus infected the same cells. These findings suggest that the replicative block occurs prior to virion assembly, and an accompanying report seeks to locate the site of restriction more precisely at the post transcriptional level. PMID- 4342240 TI - Synthesis of viral ribonucleic acid during restricted adenovirus infection. AB - The mechanism by which simian virus 40 converts the abortive adenovirus type 7 infection of monkey cells into an efficient lytic infection has been investigated. Analysis of ribonucleic acid (RNA) synthesis during unenhanced and enhanced infection of monkey cells has shown that adenovirus RNA synthesized in the abortive infection contains both "early" and "late" sequences. In hybridization competition experiments, early adenovirus RNA from human cells prevented the hybridization of only 20% of the adenovirus RNA transcribed in unenhanced infection. Further, the RNA from unenhanced cells was able to completely block the hybridization of RNA synthesized during enhanced infection. Finally, virus-associated RNA, which is a late RNA transcribed in lytic adenovirus infection, is also produced in the unenhanced infection. An accompanying paper describes a marked deficiency in adenoviral capsid protein synthesis in the unenhanced infection. We conclude that RNA sequences, which are sufficient to code for the synthesis and assembly of structural proteins of adenovirus, are transcribed but are not efficiently translated in the unenhanced adenovirus infection of monkey cells. PMID- 4342241 TI - Dissociation of vesicular stomatitis virus and relation of the virion proteins to the viral transcriptase. AB - A procedure has been developed for the sequential removal and purification of the glycoprotein and membrane protein of vesicular stomatitis virus (VSV). Neither of these proteins exhibited transcriptase activity. All of the activity was recovered in the ribonucleic acid (RNA)-ribonucleoprotein complex of VSV, which also has four other minor proteins associated with it. During transcription of 41% of the RNA of a virus preparation, no dissociation of the ribonucleoprotein from the viral RNA was observed. PMID- 4342242 TI - Model for vesicular stomatitis virus. AB - Vesicular stomatitis virus contains single-stranded ribonucleic acid of molecular weight 3.6 x 10(6) and three major proteins with molecular weights of 75 x 10(3), 57 x 10(3), and 32.5 x 10(3). The proteins have been shown to be subunits of the surface projections, ribonucleoprotein, and matrix protein, respectively. From these values and from estimates of the proportions of the individual proteins, it has been calculated that the virus has approximately 500 surface projections, 1,100 protein units on the ribonucleoprotein strand, and 1,600 matrix protein units. Possible models of the virus are proposed in which the proteins are interrelated. PMID- 4342243 TI - Study of some stages of poliovirus morphogenesis in MiO cells. AB - Five to seven minutes after addition of (14)C-amino acids to poliovirus-infected MiO cells, radioactivity is found only in 5S virus-specific structures. With increased time of labeling, radioactivity appears in considerable amounts also in the 14S area. In the presence of guanidine blocking the transition of 14S particles in subsequent structures in MiO cells, radioactivity is first detected in the 5S zone and then accumulates predominantly in 14S particles. These results indicate that formation of 5S particles and conversion of a part of their protein into 14S particles reflect the earliest stages of the morphogenesis of poliovirus. In contrast to poliovirus-infected HeLa cells, no 73S particles could be detected in MiO cells, nor could 73S structures be detected in poliovirus infected MiO cells after a short incubation period (20 to 30 min) with radioactive amino acids, although formation of 150S virions was observed. Addition of guanidine to infected MiO cells leads to accumulation of 14S particles; however, 73S particles are not detected. After removal of guanidine, radioactivity increases only in the 150S area. Incubation of 14S particles isolated from the sucrose gradient of the cytoplasmic extract of infected MiO cells resulted in formation of 73S particles. The results obtained show the modification of the late stages of poliovirus morphogenesis in MiO cells. PMID- 4342245 TI - Antigenic relationship between the herpesviruses of infectious bovine rhinotracheitis, Marek's disease, and Burkitt's lymphoma. AB - Common herpesvirus (HV) antigens in infectious bovine rhinotracheitis (IBR), Marek's disease (MDV), and Burkitt's lymphoma (EBV) were found. Immunodiffusion tests in 0.7% agarose demonstrated a line of identity with the HV preparations by using specific antisera prepared against, IBR, MDV, and EBV. These common antigens were found to consist of multiple components: i.e., at least two MDV antigens were identical to IBR and EBV components when subjected to immunoelectrophoresis in 0.7% agarose. Indirect immunofluorescence testing of EBV strain P(3)HR-1 and IBR-infected embryonic bovine kidney cells, with antisera prepared against partially purified IBR, MDV, and EBV antigens, revealed identical activity of the three antisera as demonstrated by brilliant nuclear fluorescence (perinuclear clumping) in P(3)HR-1 cells and evenly distributed cytoplasmic activity in 18-hr IBR-infected bovine kidney cell cultures. Initial physical-chemical studies of the partially purified antigens were carried out by differential centrifugation cycles (6,000, 25,000 and 100,000 x g), rate zonal centrifugation in 5 to 20% sucrose density gradients, and analysis by disc electrophoresis in 5 and 7% polyacrylamide gels. These studies revealed similar molecular weight (>1,000,000) and size characteristics and similar electrophoretic mobilities among the three partially purified HV antigens. PMID- 4342244 TI - Temperature-dependent transformation of cells infected with a mutant of Bryan Rous sarcoma virus. AB - Chick embryo cells infected with a mutant (Ta) of the Bryan high-titer strain of Rous sarcoma virus (RSV-BH) are morphologically transformed at 36 C but appear similar to uninfected cells at 41 C. When cells infected with RSV-BH-Ta are switched from 41 to 36 C, morphological changes characteristic of transformation are observable within 10 min. The transformation is reversible; cells shifted from 36 to 41 C have been observed to lose their transformed morphology within 1 hr. The transformation after a shift in temperature is unaffected by inhibition of deoxyribonucleic acid (DNA), ribonucleic acid (RNA), or protein synthesis, demonstrating that the proteins involved in the morphological change are already present. Transformed cells infected with RSV-BH or RSV-BH-Ta take up hexose and synthesize hyaluronic acid at higher rates than uninfected cells or RSV-BH-Ta infected cells grown at 41 C. However, inhibition of either protein or RNA synthesis, but not DNA synthesis, prevented the induction of increased hexose uptake and hyaluronic acid synthesis after a shift of RSV-BH-Ta-infected cells from 41 to 36 C. Therefore, these biochemical changes are secondary to a more basic change responsible for morphological transformation. PMID- 4342246 TI - Rescue of Epstein-Barr virus from somatic cell hybrids of Burkitt lymphoblastoid cells. AB - A Burkitt lymphoblastoid cell line, P3J-HR-1, was fused and hybridized to a human sternal marrow cell line. The somatic cell hybrids were negative when examined for Epstein-Barr virus (EBV) markers. When the hybrid cells were exposed to 5 iododeoxyuridine, both EBV-specific antigens and virus particles were induced as determined by the immunofluorescence test and by electron microscopy. The data presented suggest that the EBV genome can be transferred from a lymphoblastoid cell to another cell type during cell hybridization, that the EBV genome can persist in the hybrid cells for long periods of time, and that synthesis of the virus can be induced in the heterokaryons. PMID- 4342247 TI - Dissociation and reconstitution of the transcriptase and template activities of vesicular stomatitis B and T virions. AB - Transcriptase activity was dissociated from vesicular stomatitis virions by highionic-strength buffer containing Triton X-100. Considerable enzyme activity could be restored by recombining inactive sedimentable and nonsedimentable virion fractions. Reconstituted transcriptase activity was dependent on the presence of all four nucleoside triphosphates and the concentration of heat-labile molecules in both supernatant and pellet fractions. Lower NaCl concentrations removed approximately 46% of virion protein, but did not release transcriptase activity from the pellet fraction, nor could incorporation of (3)H-uridine-5'-triphosphate by complete virions be increased by adding soluble transcriptase. Evidence that the virion nucleocapsid is the transcription template was provided by finding that the pellet contained predominantly virion core nucleoprotein, ribonucleic acid, and homogeneous nucleocapsid coils when viewed by electron microscopy. Removal of envelope G and M proteins by Triton and low-salt buffer without decreasing nucleocapsid polymerase activity indicates that neither G nor M protein is necessary for transcription. Additional data are required to determine whether the minor nucleocapsid proteins L or NSl, or both, which are at least partially solubilized in high-salt buffer, are the transcriptase. Preliminary data suggest that the major N nucleoprotein, which was not solubilized by high salt buffer, is also required for transcription. Defective T virions contained at least as much transcriptase per weight as did B virions, as determined by restoration with T supernatant fluids of transcription function to B nucleocapsid template. However, the T nucleocapsid would not serve as template for B or T transcriptase, a finding which is interpreted as evidence of T template defectiveness. The presence of defective T nucleocapsids did not interfere with B or T transcriptase function reconstituted with B template. PMID- 4342249 TI - [Multiple myeloma]. PMID- 4342250 TI - [Mechanism of action of cord factor (trehalose-6,6'-dimycolate) of Mycobacterium tuberculosis]. PMID- 4342248 TI - Adenylate-rich sequences in Sendai virus transcripts from infected cells. AB - Virus-specific complementary ribonucleic acid (RNA) from cells infected with Sendai virus was isolated by a procedure involving hybridization with virion RNA and isopycnic centrifugation of the RNA hybrids. The complementary RNA contained adenylate-rich sequences which sedimented at about 4S. PMID- 4342251 TI - Mixed mesodermal tumours of the ovary. PMID- 4342252 TI - [Electroencephalographic changes in the course of non-complicated herpetic stomatitis]. PMID- 4342253 TI - Survival of cholinergic drinking following nephrectomy. PMID- 4342254 TI - Annual oration on doubt, dogma and dyspepsia. PMID- 4342255 TI - Virus diseases from pets. PMID- 4342256 TI - Observations on bovine herpes mammillitis (BHM) virus infections of heavily pregnant heifers and young calves. PMID- 4342257 TI - Inclusion body hepatitis outbreak in broiler flocks. PMID- 4342258 TI - Duck plague (duck virus enteritis) in Britain. PMID- 4342259 TI - Food poisoning and spoilage bacteria in poultry processing. PMID- 4342260 TI - [Errors in the diagnosis of the nephritis in children]. PMID- 4342261 TI - Spongioblastomas, astrocytomas and Rosenthal fibers. Ultrastructural, tissue culture and enzyme histochemical investigations. PMID- 4342262 TI - [Subacute spongiform encephalitis. Infectious genesis of the Creutzfeldt-Jakob disease]. PMID- 4342263 TI - Reflex inhibition of sympathetic nerve activity by phenoxybenzamine. PMID- 4342264 TI - Left ventricular receptors activated by severe asphyxia and by coronary artery occlusion. PMID- 4342265 TI - Vasoconstrictor fibre discharge to skeletal muscle, kidney, intestine and skin at varying levels of arterial baroreceptor activity in the cat. PMID- 4342266 TI - Cholecystokinetic effect and concentration of cyclic AMP in gall-bladder muscle in vitro. PMID- 4342267 TI - Increased renal excretion of noradrenaline in rats after treatment with prostaglandin synthesis inhibitor indomethacin. PMID- 4342268 TI - Electrophysiological studies of the echidna, Tachyglossus aculeatus. I. Waking and sleep. PMID- 4342269 TI - Electrophysiological studies of the echidna, Tachyglossus aculeatus. II. Dormancy and hibernation. PMID- 4342270 TI - Cholinergic mechanisms related to rem sleep. I. Rhythmic activity of the vestibulo-oculomotor system induced by an anticholinesterase in the decerebrate cat. PMID- 4342271 TI - Cholinergic mechanisms related to rem sleep. II. Effects of an anticholinesterase on the discharge of central vestibular neurons in the decerebrate cat. PMID- 4342272 TI - [Adenohypophyseal cytology of Chrioptera with special reference to FSH, LH, ACTH and LTH cells]. PMID- 4342273 TI - Mechanism of acetylcholine release; presynaptic inhibition by noradrenaline of acetylcholine release in autonomic nervous system. PMID- 4342274 TI - Histochemical investigation of the activity of oxidoreductases in the skin lesions of lepromatous leprosy patients. AB - THIS PAPER REPORTS AN INVESTIGATION OF THE ACTIVITY OF THREE BASIC GROUPS OF OXIDOREDUCTASES IN LEPROMATOUS LEPROSY: specific dehydrogenases, flavoprotein enzymes, and cytochrome oxidase. The activity of the enzymes was studied before treatment, at various stages of treatment during exacerbations, and in the stage of regression. The data obtained are of importance for evaluating metabolic process in the cells of the specific infiltrates and the dermal connective tissue in leprosy, for determining the nature and intensity of the inflammatory process, and for control purposes in cases of regression. PMID- 4342275 TI - Susceptibility of rodents to Japanese encephalitis virus. PMID- 4342276 TI - Ultrastructure of macrocyst formation in the cellular slime mold, Dictyostelium mucoroides: extensive phagocytosis of amoebae by a specialized cell. PMID- 4342277 TI - [Radioimmunologic method of ACTH determination]. PMID- 4342278 TI - Bilateral metastatic intraocular hemangiosarcoma in a dog. PMID- 4342279 TI - Pseudogout in a dog. PMID- 4342280 TI - Studies on microsomal glucose-6-phosphate dehydrogenase of rat liver. PMID- 4342281 TI - Studies on the role of basic amino acid residues of ACTH peptide in steroidogenesis by isolated adrenal cells. PMID- 4342282 TI - Multimolecular forms of pyruvate kinase from rat and other mammalian tissues. I. Electrophoretic studies. PMID- 4342283 TI - The nucleases from Acrocylindrium sp. I. Purification and properties of ribonuclease. PMID- 4342284 TI - The estimation of polychlorobiphenyls. PMID- 4342285 TI - A new method for preventing oxidative decomposition of catechol estrogens during chromatography. PMID- 4342286 TI - Anticholinesterase amnesia as a function of massed or spaced retest. PMID- 4342288 TI - Evolution of the lining bodies in the embryonic chick gonad. PMID- 4342287 TI - Nucleic acid content of mammary glands of virgin and pregnant gilts. PMID- 4342289 TI - A structural analysis of congenital limb deformities in experimental hyperthyroid tadpoles. PMID- 4342290 TI - Sensitization of guinea pigs to herpes simplex virus. PMID- 4342292 TI - Problems relating to the definition of an international unit for vitamin D and its metabolites. PMID- 4342291 TI - Viruses as possible factors in human cancer. PMID- 4342293 TI - Adrenal response to physical stress and the effect of adrenocorticotropic hormone in newborn infants. PMID- 4342295 TI - Intact isolated muscle cells from the adult rat heart. PMID- 4342296 TI - Hepatic inactivation of val 5 angiotensin II amide (Hypertensin), val 5 angiotensin II free acid and adrenaline in immature and adult rabbits. PMID- 4342294 TI - Hereditary adrenocortical unresponsiveness to adrenocorticotropic hormone. PMID- 4342297 TI - Improved purification and chromatography of extracts containing prostaglandins. PMID- 4342298 TI - Stages of merogony in multinucleate merozoites of Eimeria magna Perard, 1925. PMID- 4342299 TI - Results of intracecal inoculation of germfree and conventional guinea pigs and germfree rats with axenically cultivated Entamoeba histolytica. PMID- 4342300 TI - Biology of malignant neoplasia of the lymphoreticular tissues. PMID- 4342301 TI - [Capabilities of angiographic examination procedures in the diagnosis of pancreatic tumors]. PMID- 4342302 TI - The prostaglandins. PMID- 4342304 TI - A characterization of repair mechanisms operating subsequent to genetic damage induced by ethyl methanesulfonate and gamma radiation in Bracon hebetor. PMID- 4342303 TI - In vitro and host-mediated "rec-assay" procedures for screening chemical mutagens; and phloxine, a mutagenic red dye detected. PMID- 4342305 TI - Dosimetry of the chemical mutagen ethyl methanesulfonate in spermatozoan DNA from Drosophila melanogaster. PMID- 4342306 TI - Comparison of a chemical assay with a tissue-mediated bio-assay for chemical mutagens. PMID- 4342307 TI - Ultrastructure of the human mammary gland. PMID- 4342308 TI - Ultrastructural pathology of human renal cell tumors. PMID- 4342309 TI - Burkitt's lymphoma: a review of the pathology, immunology, and possible etiologic factors. PMID- 4342310 TI - Odontogenic tumors. PMID- 4342311 TI - The gastric fiberscope in the x-ray department. PMID- 4342312 TI - [Common cold]. PMID- 4342313 TI - Inhibitory effect of fenfluramine and propranolol on NADH dehydrogenase of mouse heart homogenates. PMID- 4342314 TI - Effect of methyldopa on the neurogenic component of the arterial blood pressure. PMID- 4342316 TI - Fibrosis and carcinoma of the lung in a family with haemoglobin Malmo. Anatomic findings. PMID- 4342315 TI - Phosphodiesterase inhibition as a mechanism for the diuretic activity of 1 ((tert butylimino)methyl)-2-(3-indolyl)indoline hydrochloride (MJ-8592-1). PMID- 4342317 TI - Dysfibrinogenaemia associated with primary hepatoma. PMID- 4342318 TI - Prophylactic intraocular antibiotics in cataract surgery. PMID- 4342320 TI - Yolk-sac tumour patterns and entoblastic structure in polyembryomas. PMID- 4342319 TI - [Clinical-pathogenetic significance of protein metabolism disorders in children with Botkin's disease]. PMID- 4342322 TI - Primary intracranial germ cell tumours including five cases of endodermal sinus tumour. PMID- 4342321 TI - Endodermal sinus and other yolk sac tumours, a reappraisal. PMID- 4342323 TI - Mullerian mixed tumour. PMID- 4342324 TI - An ultrastructural study of mucin secreting epithelia in ovarian neoplasms. PMID- 4342326 TI - Trophoblastic disease. PMID- 4342325 TI - Malignant external endometriosis. A case of adenocarcinoma of umbilical endometriosis. PMID- 4342327 TI - Oral polio vaccination of children in the tropics. I. The poor seroconversion rates and the absence of viral interference. PMID- 4342328 TI - The Seattle virus watch. 3. Evaluation of isolation methods and summary of infections detected by virus isolations. PMID- 4342329 TI - Human granulocyte elastase. Further delineation of its role in connective tissue damage. PMID- 4342330 TI - Preparation in gnotobiotic animals of monospecific reference serums against viruses. PMID- 4342331 TI - Immunization of pigs against Bordetella bronchiseptica infection by parenteral vaccination. PMID- 4342332 TI - Increased mortality in encephalomyocarditis virus-infected mice consuming cobalt sulfate: tissue concentrations of cobalt. PMID- 4342333 TI - Susceptibility of primary cell cultures to foot-and-mouth disease virus: effect of Eagle's nonessential amino acids. PMID- 4342334 TI - Intranasal administration of virulent viruses to cattle, with a gas-powered atomizer. PMID- 4342335 TI - [Specific antigenic extracts from Entamoeba histolytica maintained in mixed cultures. I. Obtainment. Chemical and immunological characteristics of a total extract]. PMID- 4342336 TI - The mechanism of substrate inhibition of the esterase activity of carboxypeptidase A. PMID- 4342337 TI - Preparation of intaintact plant mitochondria. PMID- 4342338 TI - Electron spin resonance in 13 C-labelled chlorophyll and 13 C-labelled algae. PMID- 4342339 TI - Hepatocarcinoma and myocardial fibrosis in an 8 and three-fourths year-old renal transplant recipient. PMID- 4342340 TI - [Current research of collagenase in the cornea and other tissues]. PMID- 4342341 TI - Clinical and experimental tumors of the kidney in tissue culture and in the chick embryo. PMID- 4342342 TI - The specificity of carcino-foetal antigens of the human digestive-tract tumours. PMID- 4342343 TI - Isolation of a C-type virus from mouse myeloma cells. PMID- 4342345 TI - Acupuncture: witchcraft or wizardry? PMID- 4342346 TI - Inguinal hernias in children--a study of 1,000 cases and a review of the literature. PMID- 4342344 TI - Effects of transient carotid occlusion on the extramitochondrial redox system in the disturbed hemisphere. PMID- 4342347 TI - International Nonproprietary Names (INN). A World Health Organization activity. PMID- 4342349 TI - In Memoriam. Elizabeth Kittredge, M.D. 1890-1972. PMID- 4342348 TI - Cosmetics, the physician and the consumer. PMID- 4342351 TI - Viral enhancement of mycoplasma growth in tracheal organ cultures. PMID- 4342350 TI - The morphology of the causal agent of bovine petechial fever (Ondiri disease). PMID- 4342353 TI - Alveolar lipo-proteinosis: an ultrastructural comparison of the experimental and human forms. PMID- 4342352 TI - Conductance properties of artificial lipidic membranes containing a proteolipid from Electrophorus. Response to cholinergic agents. AB - Previous studies have shown that a special proteolipid extract from the electric organ of Electrophorus showed high affinity binding for acetylcholine and other cholinergic agents. This proteolipid has now been incorporated into ultrathin lipidic membranes, and the membrane resistance was studied. The resistance decreased from 7.27 +/- 0.82 x 10(5) ohm cm(2) in the control membrane to 1.83 x 10(5) ohm cm(2) with addition of 72 microg/ml proteolipid. The decrease in resistance followed a potential function of order four with the proteolipid concentration in the membrane-forming solution. The presence of this proteolipid determined some type of cationic selectivity which was not observed in the control. At a critical point of proteolipid concentration the conductance spontaneously fluctuated between two levels. The membrane current jumped from one state to another by way of single discrete steps, reminiscent of those obtained with the excitatory inducing material or the macrocyclic antibiotics. In membranes containing another proteolipid having no cholinergic binding properties, the increase in conductance was smaller, and had a linear function with the concentration. In this case the "flip flop" fluctuation and the cationic selectivity were not observed. The membranes containing the cholinergic proteolipid reacted to the addition of acetylcholine by a rapid and transient increase in conductance that was considerably reduced or abolished by a previous application of d-tubocurarine. These membranes also interacted with other cholinergic agents, such as gallamine triethiodide, hexamethonium, and alpha bungarotoxin. These results suggest that this special proteolipid, when added to the artificial membranes, induces a "chemical excitability" toward cholinergic ligands. PMID- 4342354 TI - A histochemical study of mucins in normal and neoplastic human pancreatic tissue. PMID- 4342356 TI - Synovioma in a cat. PMID- 4342355 TI - Patients with cytomegalovirus infection in general practice. PMID- 4342357 TI - A comparative morphologic study of Rous rat sarcoma with normal and abnormal chromosomal pattern. PMID- 4342358 TI - Ultrastructural study of the glomerulonephritis produced by antilymphocyte globulin in monkeys. PMID- 4342359 TI - Immunoultrastructural localization of antimitochondrial antibody from the sera of patients with chronic liver disease. PMID- 4342360 TI - [Isolation of C particles from 3 cell lines in vitro from primary tumors of the lung induced with urethane in BALBc mice]. PMID- 4342361 TI - A device for measuring myocardial contractility. PMID- 4342362 TI - Tetracosactrin in the treatment of rheumatic diseases. PMID- 4342363 TI - Referred pain to the ear. PMID- 4342364 TI - Krukenberg tumor--report of two cases. PMID- 4342365 TI - [In vitro culture of normal and neoplastic glial tissue. Growth, cytology, ultrastructure]. PMID- 4342366 TI - [Comparative clinical and manometric study of hypertonic solutions and corticoids in the treatment of intracranial hypertension]. PMID- 4342367 TI - [Tumoral astroblast and reactive astrocyte: histochemical distinction by means of glutamate dehydrogenase activity]. PMID- 4342368 TI - Effects of spinal cord lesions on climbing fiber-mediated Purkinje cell inhibition in Deiter's nucleus. PMID- 4342369 TI - Skin grafting in systemic lupus erythematosus patients who are on steroids. PMID- 4342370 TI - [Indications for splenectomy in the anemic forms of myelofibrosis with myeloid metaplasia of the spleen]. PMID- 4342372 TI - Transport of low molecular weight proteins through aorta and vena cava of rats and rabbits. PMID- 4342373 TI - Kymographic recording of clot retraction: effects of papaverine, theophylline and cytochalasin B. PMID- 4342371 TI - Inhibition of thromboplastin activity in plasma by aluminosilicate treatment. PMID- 4342374 TI - [Aseptic inflammations of the maxillary sinus]. PMID- 4342375 TI - [Liver and protein metabolism]. PMID- 4342376 TI - Tubular carcinoma of the breast: a clinicopathologic study of 35 cases. PMID- 4342377 TI - Deoxycorticosterone secretion in the bullfrog: effects of ACTH, hypophysectomy, and renin. PMID- 4342378 TI - Effect of unstirred layers on oxygenation of frog gastric mucosa. PMID- 4342379 TI - Effects of high altitude on myelinogenesis in brain of the developing rat. PMID- 4342381 TI - Investigations of respiratory disease of sheep in Australia. PMID- 4342382 TI - Persistence of virus in respiratory infections of chickens. PMID- 4342380 TI - Aggregation of human blood platelets by vasopressin. PMID- 4342384 TI - The chromatographic separation of phospholipids on alumina with solvents containing ammonium salts. PMID- 4342383 TI - Role of the essential thiol groups of yeast alcohol dehydrogenase. AB - 1. Yeast alcohol dehydrogenase inactivated by reaction with iodoacetamide retains 85% of the original NADH-binding capacity as measured under conditions of saturating coenzyme concentration. 2. The dissociation constant of the enzyme NADH complex is unaffected by inactivation of the enzyme with iodoacetamide, and the affinity of the enzyme for NAD(+) and pyridine-3-aldehyde-adenine dinucleotide (PAAD(+)) appears to be similarly unaffected. 3. Enzyme inactivated with iodoacetamide has lost the ability to form normal ternary complexes of the type enzyme-NADH-acetamide and enzyme-PAAD(+)-hydroxylamine that are characteristic of the native enzyme. PMID- 4342385 TI - The activities of phosphorylase, hexokinase, phosphofructokinase, lactate dehydrogenase and the glycerol 3-phosphate dehydrogenases in muscles from vertebrates and invertebrates. AB - 1. The maximum activities of hexokinase, phosphorylase and phosphofructokinase have been measured in extracts from a variety of muscles and they have been used to estimate the maximum rates of operation of glycolysis in muscle. These estimated rates of glycolysis are compared with those calculated for the intact muscle from such information as oxygen uptake, glycogen degradation and lactate formation. Reasonable agreement between these determinations is observed, and this suggests that such enzyme activity measurements may provide a useful method for comparative investigations into quantitative aspects of maximum glycolytic flux in muscle. 2. The enzyme activities from insect flight muscle confirm and extend much of the earlier work and indicate the type of fuel that can support insect flight. The maximum activity of hexokinase in some insect flight muscles is about tenfold higher than that in vertebrate muscles. The activity of phosphorylase is greater, in general, in vertebrate muscle (particularly white muscle) than in insect flight muscle. This is probably related to the role of glycogen breakdown in vertebrate muscle (particularly white muscle) for the provision of ATP from anaerobic glycolysis and not from complete oxidation of the glucose residues. The activity of hexokinase was found to be higher in red than in white vertebrate muscle, thus confirming and extending earlier reports. 3. The maximum activity of the mitochondrial glycerophosphate dehydrogenase was always much lower than that of the cytoplasmic enzyme, indicating that the former enzyme is rate-limiting for the glycerol 3-phosphate cycle. From the maximum activity of the mitochondrial enzyme it can be calculated that the operation of this cycle would account for the reoxidation of all the glycolytically produced NADH in insect flight muscle but it could account for only a small amount in vertebrate muscle. Other mechanisms for this NADH reoxidation in vertebrate muscle are discussed briefly. PMID- 4342388 TI - Phosphorylation of the erythrocyte membrane: stimulation by adenosine 3':5' cyclic monophosphate. PMID- 4342386 TI - Control of the redox state of the nicotinamide-adenine dinucleotide couple in rat liver cytoplasm. AB - 1. A study has been made of the ability of rat liver in vivo to maintain equilibrium in the combined glyceraldehyde 3-phosphate dehydrogenase, 3 phosphoglycerate kinase and lactate dehydrogenase reactions, i.e. in the system: [Formula: see text] Attempts were made to upset equilibrium. The [lactate]/[pyruvate] ratio was rapidly changed by injection of ethanol or crotyl alcohol, and the value of [ATP]/[ADP][HPO(4) (2-)] was rapidly changed by injection of ethionine or carbonyl cyanide p-trifluoromethoxy-phenylhydrazone. 2. The concentrations of the metabolites occurring in the above equation were measured in freeze-clamped liver. 3. Although the injected agents caused large changes in the concentrations of the individual components, near-equilibrium in the system was maintained, as indicated by the fact that the value of [ATP]/[ADP][HPO(4) (2-)], referred to as the phosphorylation state of the adenine nucleotides, measured directly agreed with the value calculated for equilibrium conditions from the above equation. 4. The results are discussed and taken to confirm that the order of magnitude of the value of the redox state of the cytoplasmic NAD couple in rat liver is controlled by the phosphorylation state of the adenine nucleotide system. PMID- 4342387 TI - Influence of glucagon, 6-N,2'-O-dibutyryladenosine 3':5'-cyclic monophosphate and triamcinolone on the arginine synthetase system in perinatal rat liver. AB - 1. The administration of triamcinolone (19-190mug/animal) to postnatal rats increased the arginine synthetase system activity 1.2-2.5-fold above control values 24h after exposure to the hormone. Cortisol (hydrocortisone), however, increased the arginine synthetase system activity only when larger (190mug/animal) or repeated daily doses were given. Glucagon (100mug/animal) stimulated arginine synthetase system activity only after the second postnatal day. None of these agents increased the activity in 19.5-21.5-day foetuses after intrauterine administration. 2. The viability of foetal rat liver explants maintained in organ culture for up to 54h was validated both by ultramicroscopic examination and by incorporation of radioactive leucine and orotic acid. 3. In organ cultures of foetal rat liver explants (18.5 days to term), triamcinolone (20mug/ml of medium) evoked a 2.8-4.3-fold increase after 24h of incubation. This increase was completely inhibited by actinomycin D (25mug/ml) or cycloheximide (10mug/ml). Cortisol (5-50mug/ml) or glucagon (0.067-67mug/ml) also increased the arginine synthetase system activity above the respective control values, but there was no increase in activity with insulin (0.05-0.25i.u./ml). 4. Maximum concentrations of glucagon (67mug/ml), dibutyryl cyclic AMP (6-N,2'-O dibutyryladenosine 3':5'-cyclic monophosphate) (0.1mm) and triamcinolone (20mug/ml) incubated for 24h with foetal rat liver explants each produced between a two-and three-fold increase in the activity of the arginine synthetase system. Combinations of maximum amounts of glucagon and the cyclic nucleotide did not produce a greater effect than either agent alone. However, the combination of dibutyryl cyclic AMP with triamcinolone appeared to produce somewhat less than additive effects. 5. The effects of the cyclic nucleotide and triamcinolone were evident after 12h of incubation and increased steadily throughout the 24h of observation. This time-course of increased enzyme activity is very much slower than that reported for the induction of other enzymes in explant cultures of foetal rat liver. PMID- 4342390 TI - Adenosine 3':5'-cyclic monophosphate and adenylate cyclase in subcellular fractions of rat brain. PMID- 4342389 TI - Mode of action of adenosine 3':5'-cyclic monophosphate in insulin secretion. PMID- 4342391 TI - Partial reactions of D-glucose 6-phosphate-1L-myoinositol 1-phosphate cyclase from rat testis. PMID- 4342392 TI - Cyclic nucleotides and thyroid hormones: radioimmunoassay or protein-binding assay? PMID- 4342393 TI - Induction of adenylate cyclase activity in cultured human fibroblasts during increasing cell population density. PMID- 4342394 TI - Comparison of the multiple deoxyribonucleic acid-dependent ribonucleic acid polymerase forms of whole rat liver and a minimal-deviation rat hepatoma cell line. AB - To investigate the possibility that the pattern of multiple DNA-dependent RNA polymerases of an animal cell exerts a controlling influence on its nature, the activities of these enzymes were compared in differentiated rat liver and in a rapidly growing minimal-deviation rat hepatoma cell line by using established techniques of enzyme extraction, separation and determination. Relative to the DNA content of the tissues, RNA polymerase activities of forms AI, AII and B were approx. ninefold, twofold and twofold higher respectively in the cell line than in the liver. Tests indicated that these results could not be explained by differences in extraction efficiency or by the presence of unbound inhibitors or stimulators of polymerase activity in the final enzyme preparations. New forms of the enzyme were not detected in either tissue. The significance of these findings with respect to the possible role of multiple RNA polymerases in the control of cellular activities is discussed. PMID- 4342396 TI - Xanthine oxidase type D (dehydrogenase) in the intestine and other organs of the rat. PMID- 4342395 TI - The regulation of rat liver xanthine oxidase. Involvement of thiol groups in the conversion of the enzyme activity from dehydrogenase (type D) into oxidase (type O) and purification of the enzyme. AB - 1. The ;xanthine oxidase' activity of rat liver supernatant, most of which behaves as an NAD(+)-dependent dehydrogenase (type D) can be rapidly converted into an oxidase (type O) by thiol reagents such as tetraethylthiuram disulphide, copper sulphate, 5,5'-dithiobis-(2-nitrobenzoic acid), N-ethylmaleimide and p hydroxymercuribenzoate. Treatment with copper sulphate, if prolonged, leads to almost complete inactivation of the enzyme. The effect of these reagents is prevented by dithioerythritol, and in all cases but that of N-ethylmaleimide is reversed by the same thiol. 2. Dithioerythritol prevents and reverses the conversion of xanthine oxidase from type D into type O brought about by storage of rat liver supernatant at -20 degrees C, preincubation under anaerobic conditions, treatment with carbon or with diethyl ether, and reverses, but does not prevent, the conversion obtained by preincubation of the whole liver homogenate. 3. Conversion of the enzyme from type D into type O is effected by preincubation of rat liver supernatant with the sedimentable fraction from rat liver but not from chick or pigeon liver. The xanthine dehydrogenase activity of chick liver supernatant is not changed into an oxidase by preincubation with the sedimentable fraction from rat liver. 4. The enzyme activity of rat liver supernatant is converted from type D into type O during purification of the enzyme: the purified enzyme can be reconverted into type D by dithioerythritol. 5. The enzyme appears as an oxidase in the supernatant of rat heart, intestine, spleen, pancreas, lung and kidney. The enzyme of all organs but intestine can be converted into a dehydrogenase by dithioerythritol. PMID- 4342397 TI - Subcellular fractionation of particles containing acid hydrolases from Saccharomyces carlsbergensis. PMID- 4342398 TI - Uptake and binding of 125I-labelled prolactin by mammary tissue. PMID- 4342399 TI - Initiation by RNA polymerase on alkylated T7 DNA. PMID- 4342400 TI - A study of hyper-beta- and hyperpre-beta-lipoproteinaemia. PMID- 4342401 TI - A presynaptic mechanism evoked from brain stem reticular formation in the lumbar cord and its temporal significance. PMID- 4342402 TI - Developmental changes in ATP (CTP)tRNA nucleotidyltransferase activity of mouse brain. PMID- 4342403 TI - Synaptic inputs to the cell bodies of the giant fibers of the hatchetfish. PMID- 4342404 TI - Postsynaptic responses of hippocampal neurons to mesencephalic stimulation: hyperpolarizing potentials. PMID- 4342405 TI - Antibodies to Epstein-Barr virus (EBV) in American patients with Burkitt's lymphoma. PMID- 4342406 TI - Immunologic impairment in bronchogenic carcinoma: a study of lymphocyte response to phytohemagglutinin. PMID- 4342407 TI - Lung cancer: clinical trial of radiotherapy alone vs. radiotherapy plus cyclophosphamide. PMID- 4342408 TI - Relative frequency of ovarian neoplasms in children and adolescents. PMID- 4342409 TI - Small cell (oat cell) carcinoma of minor salivary gland origin. PMID- 4342410 TI - Cushing's syndrome and avascular necrosis of bone associated with carcinoid-islet cell tumor of the pancreas. PMID- 4342411 TI - Osteoblastic metastases in small-cell (oat-cell) carcinoma of the lung. PMID- 4342412 TI - Increased plasma aldosterone concentration in response to hemodialysis in nephrectomized man. PMID- 4342413 TI - Spread of excitation in the atrioventricular node of isolated rabbit hearts studied by multiple microelectrode recording. PMID- 4342415 TI - Sero-epidemiology of reovirus type 3 infections in four areas of Uganda with varying incidence of Burkitt's tumour. PMID- 4342414 TI - Isolation and characterization of Tetrahymena pyriformis GL mitochondria. PMID- 4342416 TI - [Use of nucleic acid hybridization technics for studies of molecular biology]. PMID- 4342417 TI - [The effect of neurotoxic factors on the energy metabolism of the brain]. PMID- 4342418 TI - Principles and modifications of radioimmunological assays of protein hormones. PMID- 4342420 TI - Practical use of plasma immunoreactive ACTH measurements. PMID- 4342419 TI - Radioimmunoassay for plasma ACTH. PMID- 4342421 TI - Problems connected with the labeling of angiotensin and small polypeptides. PMID- 4342422 TI - Parallel radioimmunoassays of angiotensin I and of angiotensin II for measurement of renin activity and of circulating active hormone in human plasma. PMID- 4342423 TI - Three family placement programs in Belgium and The Netherlands. PMID- 4342424 TI - Red blood cell and plasma phospholipids in aged humans. PMID- 4342425 TI - Recognition across visual fields and age. PMID- 4342426 TI - Characterization of guinea pig plasma lipoproteins: the appearance of new lipoproteins in response to dietary cholesterol. AB - Dietary cholesterol induces a hemolytic anemia in guinea pigs, accompanied by changes in the lipid composition of red cells and of plasma lipoproteins. This report presents a characterization of the lipoprotein species present in each main density class in both control and cholesterol-fed guinea pigs. Traces of a typical high density lipoprotein (HDL) were detected in control plasma. HDL from cholesterol-fed, anemic guinea pigs differed from control HDL in electron microscopic appearance and lipid and peptide composition. Long stacks of discs were observed in the electron microscope in addition to smaller, spherical particles characteristic of control HDL. Low density lipoproteins (LDL) from cholesterol-fed, anemic guinea pigs had two main populations, which were separated by gel chromatography. One population appeared in the electron microscope as large transparent discs and contained mainly unesterified cholesterol and phospholipids in a 2:1 molar ratio. The other population resembled control LDL in size and composition except for its high unesterified cholesterol content. Dietary cholesterol also altered the composition and decreased the electrophoretic mobility of very low density lipoproteins. Gel electrophoretic and immunochemical evidence indicates that a peptide (mol wt 35,000) appears in lipoproteins from cholesterol-fed, anemic guinea pigs that is undetectable in those of controls. Similarities between the cholesterol-induced lipoprotein abnormalities in guinea pigs and those reported in patients with obstructive jaundice, biliary cirrhosis, type III hyperlipoproteinemia, or familial lecithin:cholesterol acyltransferase deficiency are discussed. PMID- 4342427 TI - Structures of ceramide tetrasaccharides from various sources: uniqueness of rat kidney ceramide tetrasaccharide. AB - Methylation analysis of ceramide tetrasaccharide isolated from human erythrocytes gave acetates of 2,3,6-tri-O-methylgalactitol and 2,4,6-tri-O-methylgalactitol in a ratio of 1:1, and about 50% of the galactose was oxidized by periodate. Rat kidney ceramide tetrasaccharide gave, in contrast, a much larger proportion of the acetates of 2,4,6-tri-O-methylgalactitol (ratio 1:0.3), and less than 20% of the galactose was oxidized by periodate. Sequential degradation by beta-N acetylhexosaminidase, alpha-galactosidase, and beta-galactosidase showed ceramide tetrasaccharides to have identical carbohydrate sequences and anomeric structures. The major part of ceramide trihexoside derived from rat kidney ceramide tetrasaccharide migrated on thin-layer chromatography more slowly than that derived from other ceramide tetrasaccharides. The structure of a major part of rat kidney ceramide tetrasaccharide was thus determined to be GalNAcbeta(1- >3)Galalpha(1-->3)Galbeta(1-->4)Glcbeta(1-->1)Cer, whereas other ceramide tetrasaccharides have Galalpha(1-->4) structure at the penultimate residue. PMID- 4342429 TI - Ultrastructure of Thraustochytrium sp. zoospores. II. Striated inclusions. PMID- 4342428 TI - Ultrastructure of initial crystal formation in dentin. PMID- 4342430 TI - [Radiographic diagnosis of malignant bile duct cancer]. PMID- 4342431 TI - [Radioisotope scanning of the pancreas. 4. Pancreatic diseases]. PMID- 4342432 TI - Action of 1,25-dihydroxycholecalciferol, a potent, kidney-produced metabolite of vitamin D, in uremic man. PMID- 4342433 TI - Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 44-1972. PMID- 4342434 TI - A confusion of vitamin D's. PMID- 4342435 TI - Bronchial adenomas. PMID- 4342436 TI - Purification and characterization of lymphocyte mediators in cellular immunity: comparative studies on migration inhibitory factor (MIF) chemotactic factor for macrophages and lymphotoxin. PMID- 4342437 TI - Postural hypotension in amyloid disease. PMID- 4342438 TI - [A new detection method for traces of cyanides from their metabolites in decomposed human body tissues in forensic studies]. PMID- 4342440 TI - Neonatal cytomegalic inclusion disease chorioretinitis. PMID- 4342439 TI - Latent herpes simplex virus. Isolation from rabbit trigeminal ganglia between episodes of recurrent ocular infection. PMID- 4342441 TI - Primary cytomegalovirus infection and hepatitis in a renal allograft recipient. PMID- 4342442 TI - Adenyl cyclase activity in failing hearts of genetically myopathic hamsters. PMID- 4342443 TI - The effects of stimulating the somatic sensory cortex on single neurones in the posterior group (PO) of the cat. PMID- 4342444 TI - The monoamine metabolism in viral encephalitides of the mouse. II. Turnover of monoamines in mice infected with herpes simplex virus. PMID- 4342445 TI - Gap junctions between dendrites in the primate neocortex. PMID- 4342446 TI - Maturational status of inhibitory and excitatory synaptic activities of thalamic neurons in neonatal kitten. PMID- 4342448 TI - Adenoid cystic carcinoma of the breast. AB - Adenoid cystic carcinomas of breast are rarely recorded tumors affording an excellent prognosis. This present report documents three new cases and reviews the literature. Histologic features distinguishing it from cribriform intraductal carcinoma are emphasized. PMID- 4342449 TI - Interaction of microsomal cytochrome P-450 with spin-labelled substrates. PMID- 4342447 TI - Dysautonomia--its significance in neurologic disease. PMID- 4342450 TI - Reaction of alkylating mutagens and carcinogens with nucleic acids: detection and estimation of a small extent of methylation at O-6 of guanine in DNA by methyl methanesulphonate in vitro. PMID- 4342451 TI - Changes of enzymic activity in mesonephros as a function of age. PMID- 4342452 TI - Pyruvate kinase in muscle extracts of the sea mussel Mytilus edulis L. PMID- 4342453 TI - Localization and metabolism of 1,2- 3 H-vetamin D 3 and 26,27- 3 H-25 hydroxycholecalciferol in goldfish (Carassius auratus L.). PMID- 4342454 TI - Enzyme activity patterns in white and red muscle of the eel (Anguilla anguilla) at different developmental stages. PMID- 4342455 TI - Fructose 1,6-diphosphatase activity in rat mammary glands. PMID- 4342456 TI - Quantitative comparison of the mitochondrial populations in the livers of newborn and weanling rats. PMID- 4342457 TI - [convalescence in the aged]. PMID- 4342458 TI - Leukocyte mitochondria: function and biogenesis. PMID- 4342460 TI - ACTH, corticoids and luteal function in heifers. PMID- 4342459 TI - NAD, ATP and lipid contents in normal and leukemic human leukocytes, before and after cytostatic therapy. PMID- 4342461 TI - Electrophysiological analysis of peripheral neurones and their possible role in the local reflexes of a mollusc. PMID- 4342462 TI - A neural correlate of behavioural stimulus intensity discrimination in a mollusc. PMID- 4342463 TI - The use of exogenous myoglobin as an ultrastructural tracer. Reabsorption and translocation of protein by the renal tubule. PMID- 4342464 TI - Bis-(4,4'-diamino-2,2'-bipyridyl)-ferrous chloride as an electron-dense probe for cytochrome c. PMID- 4342465 TI - Titers of antibody to Epstein-Barr virus in patients with cat-scratch disease. PMID- 4342466 TI - Diagnosis and management of hypopituitarism. PMID- 4342467 TI - Treatment of herpes simplex encephalitis. PMID- 4342470 TI - The pharmacology of the neostigmine-like facilitatory drug effect at the mammalian neuromuscular junction. PMID- 4342469 TI - New aspects of drug actions on transmitter liberation from adrenergic nerve terminals. PMID- 4342468 TI - [Natural carcinogens: hepatic disorders in the rat caused by cycasin, with special reference to the induction of hepatic tumors]. PMID- 4342471 TI - Fate of the neurotransmitter noradrenaline and regulation of its biosynthesis. PMID- 4342472 TI - Studies on the zonal function of adenyl cyclase activities in the adrenal gland. PMID- 4342474 TI - Adenoid cystic carcinoma of the cervix with myoochondroid change. Report of a case. PMID- 4342473 TI - [Ultrastructural study of a Langerhans's adenoma. Electron microscope demonstration of insulinogenous granulations]. PMID- 4342475 TI - Tetracosactrin in the treatment of rheumatic diseases. PMID- 4342476 TI - [Demonstration of the nonspecific factors which regulate the immune response in rabbit spleen cell cultures]. PMID- 4342478 TI - The infleunce of silica and aluminium on the cytochrome c-oxidase activity of rat lung homogenate. PMID- 4342477 TI - [Activating role of certain hormonal polypeptides in the equilibration mechanism of functions of the body]. PMID- 4342479 TI - The quality of nerve regeneration. Factors independent of the most skillful repair. PMID- 4342480 TI - Nerve grafting in peripheral nerve. PMID- 4342481 TI - [Persistence of primary teeth ]. PMID- 4342482 TI - HL-A types in Danish Eskimos from Greenland. PMID- 4342483 TI - [Participation of catecholamines in the regulation of carbohydrate metabolism of skeletal muscles in ontogenesis]. PMID- 4342484 TI - Coiled nucleocapsid configuration in subacute sclerosing pancencephalitis (SSPE). PMID- 4342485 TI - [Ultrastructural study of the corpus callosum in Jimpy mice]. PMID- 4342486 TI - The lysosomal enzymes in lymphocytes. I. Normal lymphoid tissue. PMID- 4342487 TI - Management of the facial nerve in parotid gland surgery. PMID- 4342488 TI - Mucoepidermoid carcinoma of the salivary gland. PMID- 4342490 TI - Metabolism of (4- 14 C)oestradiol by oestrogen-induced uterine peroxidase. AB - 1. An enzyme that catalyses the metabolism and binding of [4-(14)C]oestradiol to protein and to other high-molecular-weight substances in the presence of H(2)O(2) was shown to be absent from the uteri of immature rats and to be induced by physiological doses of oestrogen or pregnant-mare-serum gonadotrophin. 2. The pH optimum, stability to heat and other characteristics of the uterine enzyme system as well as its subcellular distribution were determined. 3. The increase in the ability of uterine preparations to convert [4-(14)C]oestradiol into water-soluble products as a result of oestrogen treatment was accompanied by an increase in peroxidase and NADH oxidase activities and was inhibited by actinomycin D and cycloheximide. 4. The results support the proposal that the increase in peroxidase activity after oestrogen treatment might be part of an adaptive response of the uterus permitting it to bind and inactivate oestrogens and thus limit the duration of their effect upon this target tissue. PMID- 4342489 TI - Disequilibrium in the malate dehydrogenase reaction in rat liver mitochondria in vivo. AB - 1. When [2-(14)C]pyruvate is injected into rats the C3-position of liver glutamate becomes more heavily labelled than the C2-position, thus establishing that oxaloacetate and fumarate are not in equilibrium in rat liver mitochondria in vivo. The amount of disequilibrium was shown to be simply related to the value that the C3-label/C2-label ratio would have were no label recycled. This ratio, z, was calculated for post-absorptive rats in environmental temperatures of 20 degrees and 30 degrees C from determinations of the distribution of label within glutamate 1, 3 and 10min after intravenous injection of [2-(14)C]pyruvate. The values of z (best estimate and range) were 1.65 (1.60-1.69) in rats at 20 degrees C and 2.43 (2.23-2.63) in rats at 30 degrees C. These values of z imply the following rates of interconversion in mitochondria of fumarate and oxaloacetate (in terms of the oxaloacetate-->citrate flux, R) in rats at 20 degrees C: [Formula: see text] and in rats at 30 degrees C: [Formula: see text] 2. The kinetic parameters of malate dehydrogenase and fumarate hydratase and the intramitochondrial concentrations of NAD(+) and NADH under (as far as could be judged) conditions in vivo were collated. From them and the best estimates of R now available were calculated the rates of interconversion of fumarate, malate and oxaloacetate required to give the found values of z. These rates showed that the fumarate hydratase reaction was nearly in equilibrium, but that the malate dehydrogenase reaction was considerably out of equilibrium. The calculations also led to the following conclusions. 3. In livers of rats at 20 degrees and 30 degrees C mitochondrial malate concentrations were respectively about 5 and 1.5 times mean cellular concentrations. 4. Mitochondrial oxaloacetate concentrations were less than 0.2 of the mean cellular concentrations. They were also only 0.65 and 0.55 of the equilibrium concentrations for the malate dehydrogenase reaction in rats at 20 degrees and 30 degrees C respectively. 5. Malate dehydrogenase activity was low because of the very low oxaloacetate concentrations in the mitochondria and the very small fraction of the enzyme complexed with NAD(+), i.e. in each direction one substrate concentration was very sub-optimal. PMID- 4342492 TI - The control of glycerol utilization by glucose metabolism. PMID- 4342491 TI - A procedure for the isolation and determination of deoxyribose derivatives. AB - A method of determining deoxyribose derivatives in biological material is described. It has high sensitivity, and is particularly useful in that it can be applied to a large range of tissues for which the other available assays are unsuitable. This is because the method is applicable to complex mixtures of nucleotides in which such substances as ribonucleotides are present in very large excess over deoxyribonucleotides, and it is not necessary to equilibrate the nucleotide-precursor pool with radioactive phosphate. The method has mainly been developed with the object of determining deoxyribonucleoside triphosphates, but it can be used to assay ribonucleoside triphosphates, as well as the mono- and diphosphates of both types of nucleoside. The procedure used involves three basic techniques: (1) periodate oxidation and methylamine-induced cleavage of the sugar ring to destroy 2'- and 3'-unsubstituted ribonucleosides; (2) column chromatography to separate the deoxyribonucleotides from each other and from other substances, such as the products of the periodate oxidation; (3) fluorimetric determination of deoxyribose after labilization of the pyrimidine glycosidic bond by bromination of the heterocyclic ring. Each of these three procedures can be used independently, in conjunction with other analytical procedures. PMID- 4342493 TI - Extracellular concentrations of adenosine 3':5'-cyclic monophosphate during axenic growth of myxamoebae of the cellular slime mould Dictyostelium discoideum. PMID- 4342494 TI - Phosphatidylinositol kinase activity in Saccharomyces cerevisiae. PMID- 4342495 TI - Stereospecificity of hydride transfer in the flavin mono-oxygenase orcinol hydroxylase. PMID- 4342496 TI - The functional significance of variants of fructose 1,6-diphosphatase in the gill and hypodermis of a marine crustacean. A kinetic study. AB - 1. In the hypodermis and gill of the Crustacea fructose 1,6-diphosphatase (EC 3.1.3.11) functions at a primary branch point between glycogen and chitin synthesis. In these tissues of the Arctic king-crab, Paralithodes camtchatica, fructose diphosphatase occurs in two electrophoretically distinguishable forms. 2. Fructose diphosphatase I (pI7.2-7.5) accounts for 70 and 10% of total fructose diphosphatase activity in the hypodermis and gill respectively, whereas fructose diphosphatase II (pI5.3) accounts for 30 and 90% of the total activity in the two tissues. Both forms display a neutral pH optimum, have an absolute requirement for a bivalent cation, and are potently inhibited by high concentrations of AMP and substrate. 3. Fructose 1,6-diphosphate saturation follows Michaelis-Menten kinetics for both fructose diphosphatases; the K(m) (fructose diphosphate) for fructose diphosphatase I is somewhat higher than for fructose diphosphatase II. In the presence of 50-200mm-K(+), the K(m) (fructose diphosphate) increases and at high concentrations of K(+) fructose diphosphate saturation follows sigmoidal kinetics. 4. UDP-N-acetylglucosamine and UDP-glucose at high concentrations specifically and potently inhibit fructose diphosphatase II, but do not significantly affect fructose diphosphatase I activity. 5. Low concentrations of UDP-N-acetylglucosamine activate fructose diphosphatase II by a decrease in the apparent K(m) (fructose diphosphate), but fructose diphosphatase I is again refractory to UDP-N-acetylglucosamine under these conditions. 6. In the presence of K(+) and UDP-N-acetylglucosamine, fructose diphosphatase II is able to compete for limiting fructose diphosphate about three times more effectively than is fructose diphosphatase I. 7. AMP inhibition of both forms of the enzyme is subject to three independent variables: (a) alkaline pH increases the K(i) (AMP), (b) K(+) decreases the K(i), increases the sigmoidicity of inhibition kinetics, increases the maximum inhibition attained, and abolishes the effect of pH on AMP inhibition, and (c) Mg(2+) strongly de-inhibits AMP-inhibited fructose diphosphatase. 8. It is postulated that the presence of two forms of fructose diphosphatase aids controlled channelling of carbon through the fructose diphosphatase ;bottleneck' either towards glycogen synthesis or chitin synthesis, but not towards both simultaneously. PMID- 4342498 TI - The bacterial oxidation of picolinamide, a photolytic product of Diquat. AB - The pathway of oxidation of picolinamide (pyridine-2-carboxamide) by a Gram negative rod has been elucidated. Under conditions of high pH, restricted aeration and high substrate concentration, whole cells released 2,5 dihydroxypyridine into culture supernatants. Sodium arsenite at 5mm caused whole cells to accumulate 6-hydroxypicolinate, and, at 1mm, pyruvate, in culture media. Whole cells oxidized picolinamide, picolinate, 6-hydroxypicolinate, maleamate and maleate without lag. Cell-free extracts converted picolinamide into picolinate, and hydroxylated picolinate to 6-hydroxypicolinate. The hydroxylase was particulate, but could be solubilized by ultrasonic treatment; it required NAD(+) for activity, and did not require molecular oxygen. 2,5-Dihydroxypyridine was converted into maleamate and formate by an oxygenase requiring GSH and Fe(2+). Maleamate was deamidated to maleate, and maleate isomerized to fumarate, by unsupplemented extracts. PMID- 4342497 TI - The interaction of catecholamines and adrenal corticosteroids in the induction of phosphopyruvate carboxylase in rat liver and adipose tissue. AB - Catecholamines induced an increase in the activity of rat adipose tissue and liver phosphopyruvate carboxylases that was maintained for 48h. The response of adipose tissue phosphopyruvate carboxylase was blocked by actinomycin D, corticosteroids and propranolol, whereas corticosteroids and propranolol did not affect the liver enzyme. Cortisol phosphate, like actinomycin D, interfered only with the initiation of the increase in enzyme activity caused by noradrenaline, but not with the process of enzyme accumulation. In contrast, cycloheximide was effective in blocking enzyme induction throughout the course of the catecholamine effect. Adrenocorticotrophic hormone caused a short-term induction of adipose tissue phosphopyruvate carboxylase, which could be blocked by propranolol. Hepatic phosphopyruvate carboxylase, but not the adipose tissue enzyme, was induced by dibutyryladenosine 3':5'-cyclic monophosphate and by glucagon. Both nicotinic acid and nicotinamide decreased the normal induction of adipose tissue phosphopyruvate carboxylase caused by starvation, but only nicotinamide increased the activity of the liver enzyme. PMID- 4342499 TI - The bacterial oxidation of N-methylisonicotinate, a photolytic product of paraquat. AB - Two bacteria have been isolated that are capable of oxidizing N methylisonicotinate, a photodegradation product of Paraquat (1.1'-dimethyl-4,4' bipyridylium ion). N-Methylisonicotinate-grown cells of strain 4C1, a Gram positive rod, oxidized 2-hydroxy-N-methylisonicotinate without lag. Cell-free extracts of these cells converted 2-hydroxyisonicotinate into 2,6 dihydroxyisonicotinate; the reaction did not require molecular oxygen. Maleamate was deamidated and maleate isomerized to fumarate by soluble enzyme systems. [(14)C]Formaldehyde was isolated as the dimedone derivative from the supernatant of a cell suspension oxidizing N-[(14)C]methylisonicotinate, and no [(14)C] methylamine was detected. Whole cells incubated with N-methyl[carboxy (14)C]isonicotinate released 95% of the radioactivity as (14)CO(2). The second bacterium, strain 4C2, a Gram-negative rod, did not oxidize any of the mono- or di-hydroxypyridines or their N-methyl derivatives that were available or could be synthesized; nor did cell-free extracts oxidize any of these compounds. Methylamine was oxidized by whole cells without lag; cell-free extracts converted methylamine into formaldehyde when a soluble enzyme system requiring an electron acceptor was used; formaldehyde was oxidized to formate and formate to CO(2) by enzyme systems requiring NAD(+). PMID- 4342500 TI - Particulate malate oxidation in strictly aerobic bacteria: the respiratory system of Moraxella lwoffi. PMID- 4342501 TI - Effects of early visual experiences on the metabolism of adenosine 3':5'-cyclic monophosphate in chick brain. PMID- 4342503 TI - Viral infection and asthma. PMID- 4342502 TI - Bile acids: a pH dependent antibacterial system in the gut? AB - Bile acids are secreted in the bile in the form of conjugates and many species of intestinal bacteria can rapidly deconjugate them. Studies have shown that an unconjugated bile acid may have bactericidal and bacteriostatic effects, which are pH dependent. It is proposed that unconjugated bile acids may be involved in a homoeostatic mechanism, preventing bacterial growth in the small intestine. PMID- 4342504 TI - E.C.T. and cAMP excretion. PMID- 4342506 TI - [The evoked potential at the surface of the olfactory bulb of a dipneust and its variations according to living habits]. PMID- 4342505 TI - [Release of follicle stimulating hormone (FSH) from the rat pituitary in vitro due to the effect of potassium ions]. PMID- 4342507 TI - [Arginine kinase of soluble proteins of the adductor muscle of the Portugese oyster (Crassostrea angulata Lmk) and of the Japanese oyster (Crassostrea gigas Th.)]. PMID- 4342508 TI - Histochemical assessment of myocardial function. PMID- 4342510 TI - [Study of the viral etiology of acute respiratory diseases in workers at a light industry plant]. PMID- 4342509 TI - How an acute rise in arterial pressure damages arterioles. Electron microscopic changes during angiotensin infusion. PMID- 4342511 TI - [Current state in the problems of infectious mononucleosis and EB virus]. PMID- 4342512 TI - Antiviral properties of 1-allyl and 1-crotyl derivatives of 2-( -hydroxybenzyl) benzimidazole. PMID- 4342513 TI - Storing of secretory material inside the perinuclear space. PMID- 4342514 TI - Abnormalities of lung lipids following inhalation of quartz. PMID- 4342516 TI - Raphide crystal cell development in leaves of Psychotria punctata (Rubiaceae). PMID- 4342515 TI - Selective gonadotrophin uptake by mouse ovarian carcinoma. PMID- 4342517 TI - Turnover of plasma membrane during phagocytosis. PMID- 4342518 TI - Cytotoxic compounds. XIV. Reactions of the bismethanesulphonates of 3 arylthiopropane-1,2-diols and of 2-arylthiopropane-1,3-diols with nucleophiles. PMID- 4342519 TI - Cytotoxic compounds. XV. Reactions of the methanesulphonates of 1-arylthiopropan 2-ols and of 2-(2,4-dinitrophenylthio)propan-1-ol with nucleophiles. PMID- 4342520 TI - [Distal and congenital myopathy with hypertrophy of the calves. Presence of mitochondrial anomalies]. PMID- 4342521 TI - Spinal pathways projecting to the cerebral first somatosensory area in the monkey. AB - 1. Potentials evoked with short latency in the cerebral post-central gyrus after intradermal electrical, or adequate light tactile stimulation of the contralateral body half have been studied in the monkey, before and after transection of different spinal pathways at the upper cervical level.2. Initially, positive potentials evoked by both types of stimulus were recorded after transection of the dorsal funiculi with the same somatotopic, topographical distribution as before the lesion.3. The potentials recorded after transection of the dorsal funiculi could be evoked via one pathway located in the dorsal half of the lateral funiculus ipsilateral to the afferent input, and another pathway located, at least partially, in the ventral funiculus contralateral to the afferent input.4. Of these two pathways, the crossed ventral pathway was found necessary to keep the topographical distribution of the evoked potentials unaltered. PMID- 4342522 TI - A comparison of chemical and electrical synaptic transmission between single sensory cells and a motoneurone in the central nervous system of the leech. AB - In leech ganglia, three sensory cells of different modality converge on a motoneurone, where they form chemical and electrical synapses. Each of these synapses behaves in a characteristic manner and the nature of the transmission mechanism has significant functional consequences for the operation of the reflexes. An analysis has been made of the effects of trains of impulses on synaptic transmission through these pathways, using frequencies that correspond to natural firing.1. At the chemical synapse between the nociceptive sensory cell and the motoneurone, two opposing events occur: facilitation and depression. Thus, with trains of impulses, the synaptic potentials first increase in amplitude and then decrease. The two processes could be separated by altering the Mg and Ca content of the bathing fluid. In concentrations of Mg that reduced the amplitude of a single control chemical synaptic potential, pure facilitation occurred during a train. Depression predominated during brief trains in raised concentrations of Ca, although synaptic potentials were initially larger. These results suggest that changes in the amount of transmitter released by each presynaptic action potential can account for the changes observed in chemical synaptic transmission.2. In contrast, electrical transmission between the sensory cell responding to touch and the same motoneurone did not show facilitation or depression. The electrical coupling potential in the motoneurone was relatively constant when the touch cell fired at high or low frequencies in normal Ringer fluid, high Mg, or high Ca fluid.3. Further differences between chemical and electrical synapses were apparent when the preparation was cooled to 4 degrees C. In the cold the latency of chemically evoked synaptic potentials in the motoneurone increased and their amplitude declined drastically with repetitive stimulation, while electrical coupling potentials were unaffected.4. A brief hyperpolarization of the presynaptic cell by injected current produced a marked and prolonged increase in chemically evoked synaptic potentials, but did not influence electrical synaptic transmission.5. The synapses of the sensory cell responding to pressure, which are both chemical and electrical, behaved as expected: the chemical synaptic potentials showed facilitation and depression while electrical transmission remained relatively constant.6. These experiments emphasize the different functional consequences of electrical or chemical synapses in reflex pathways for the transmission of signals that arise as a result of natural sensory stimuli. PMID- 4342524 TI - Some observations on clindamycin. PMID- 4342523 TI - [A simple sensitive micromethod for measurement of human plasma renin concentration]. PMID- 4342525 TI - Urinary cyclic AMP in Graves's disease. PMID- 4342526 TI - EBV antibody in sera of non-human primates. PMID- 4342527 TI - Control of nuclear RNA synthesis in 2-cell and 4-cell mouse embryos. PMID- 4342529 TI - Intermediate in SV40 DNA chain growth. PMID- 4342528 TI - Microtubules in transcellular movement of procollagen. PMID- 4342530 TI - [Peripheral nerve lesious in neurologic vitamin B12 deficiency syndromes]. PMID- 4342531 TI - [Secreting insulinoma in a 14-year-old boy]. PMID- 4342532 TI - [Intensive fattening in Ivory Coast]. PMID- 4342533 TI - [Trials of intensive fattening of Mali zebus in Ivory Coast]. PMID- 4342534 TI - [Trials of intensive feeding of bull-calves (Jersey x N'Dama) in Ivory Coast]. PMID- 4342535 TI - [Study, in Ivory Coast, of the growth of N'Dama bull-calves maintained by following different ways of fatteing]. PMID- 4342536 TI - [Clinical trial of a new water soluble contrast medium with lumbosacral radiculography--Dimer-X]. PMID- 4342537 TI - Malignant eye tumours in New Zealand. PMID- 4342538 TI - [Activity profile as an additional tool in brain scanning]. PMID- 4342539 TI - [Significance of photographic subtraction in the angiographic diagnosis of vascular abnormalities and tumors of the neck and temporal bone]. PMID- 4342540 TI - [Multivesicular structures in different cells of the chicken's allantoic and vitelline membranes]. PMID- 4342541 TI - Action of tubocurarine and atropine on the crossed olivocochlear bundles. PMID- 4342542 TI - Human prolactin. An ancient molecule provides new insights for clinical medicine. PMID- 4342543 TI - Studies in a case of Cushing's syndrome due to an ACTH-producing thymic tumour. PMID- 4342544 TI - Some ultrastructural features of Rhodosporidium toruloides Banno. PMID- 4342545 TI - Partial purification of cytochromes from Bacillus caldolyticus and Bacillus caldotenax. PMID- 4342546 TI - Effect of antibiotics on the development and stability of mitochondrial enzymes in saccharomyces cerevisiae. PMID- 4342547 TI - [Idiopathic pulmonary fibrosis and bronchioalveolar carcinoma. 2 anatomoclinical observations]. PMID- 4342548 TI - General ligands and (Co)substrate elution in affinity chromatography. PMID- 4342549 TI - The identity of shikimate dehydrogenase and quinate dehydrogenase in Aspergillus niger. PMID- 4342550 TI - Formation of glucose from glucose 6-phosphate by rat brain slices. PMID- 4342551 TI - Synaptosome beds: a method for the study in vitro of the metabolism and function of nerve endings. PMID- 4342552 TI - Glycerylphosphorylcholine phosphodiesterase in rat liver. Subcellular distribution and localization in plasma membranes. AB - 1. A simple new assay for glycerylphosphorylcholine phosphodiesterase is described, in which radioactive glycerylphosphorylcholine is used as substrate and the reaction products are separated by adsorption on an anion-exchange resin. 2. Rat liver subcellular fractions contained both particulate (58%) and soluble (42%) glycerylphosphorylcholine phosphodiesterase. Both activities released free choline from glycerylphosphorylcholine. 3. The particulate glycerylphosphorylcholine phosphodiesterase was recovered mainly in the nuclear and microsomal fractions and showed a distribution similar to those of 5' nucleotidase and alkaline phosphodiesterase I, both of which are constituents of the liver plasma membrane. 4. During purification of plasma membranes glycerylphosphorylcholine phosphodiesterase, 5'-nucleotidase and alkaline phosphodiesterase I showed largely similar behaviour, indicating that glycerylphosphorylcholine phosphodiesterase is also localized in liver plasma membranes. Slight differences in the distributions of these three enzymes in density-gradient separations are discussed in relation to the possibility that they are unevenly distributed on different areas of the cell surface. 5. The differences between glycerylphosphorylcholine phosphodiesterase and alkaline phosphodiesterase I indicate that these two activities are not functions of a single enzyme. 6. The glycerylphosphorylcholine phosphodiesterase of liver plasma membranes has a pH optimum of 8.5 and a K(m) for glycerylphosphorylcholine of 0.95mm. It is inhibited by EDTA and fully reactivated by a variety of bivalent cations (and Fe(3+)). PMID- 4342553 TI - Further studies on the lipids of corynebacteria. The mannolipids of Corynebacterium aquaticum. AB - 1. The major free lipids of Corynebacterium aquaticum were characterized as dimannosyl diglyceride, monomannophosphoinositide and phosphatidylethanolamine. Bisphosphatidylglycerol and phosphatidylglycerol were also tentatively identified. 2. We regard this as the only well-documented case of an organism containing monomannophosphoinositide to the exclusion of dimannophosphoinositides and the higher homologues. 3. The co-existence of the two mannolipids in one organism is a distinctive feature. So also is the presence of phosphatidylethanolamine in a corynebacterium. 4. The monomannophosphoinositide apparently does not utilize phosphatidylinositol as a precursor, unlike the monomannophosphoinositide of Propionibacterium shermanii. CDP-diglyceride may be necessary for its synthesis. PMID- 4342554 TI - Glycerylphosphorylcholine phosphodiesterase in rat liver plasma membranes. PMID- 4342555 TI - Phosphatidylinositol turnover stimulated by acetylcholine: subcellular distribution in rat cerebral cortex. PMID- 4342557 TI - Effects of electrical stimulation, tetrodotoxin and cinchocaine on phosphoinositide metabolism in isolated rabbit vagus nerve. PMID- 4342556 TI - Metabolism of fatty acids by bovine spermatozoa. AB - The incorporation of (14)C-labelled myristic, palmitic, stearic, oleic and linoleic acids in vitro into the lipids of bovine spermatozoa was measured at intervals from 2min to 2h. All acids were rapidly incorporated into diglycerides, myristic acid being metabolized to the greatest extent. Whereas the low incorporation of acids into total phospholipids reflected the relative stability of the major phospholipid fractions in sperm, the minor phospholipids, particularly phosphatidylinositol, showed comparatively high metabolic activity. Although, in general, saturated acids were incorporated more actively than unsaturated substrates, stearic acid was poorly incorporated into all lipids except phosphatidylinositol. In regard to fatty acid composition of sperm lipids it was notable that diglycerides contained myristic acid as the major component, and this acid was also a prominent moiety of phosphatidylinositol. Docosahexaenoic acid was the principal fatty acid of the major phospholipid classes. These findings have been discussed in relation to the role of lipids in the metabolism of spermatozoa. PMID- 4342558 TI - The time-course of the effects of ethanol on the redox and phosphorylation states of rat liver. AB - 1. The time-course of the effects of ethanol administration on the metabolite concentrations, redox states and phosphorylation state was studied in the freeze clamped liver of starved rats. The response was found to vary with the time after ethanol administration. 2. Administration of ethanol caused an immediate decrease in the [NAD(+)]/[NADH] ratio of both cytoplasm and mitochondria, which persisted over the 30min studied. 3. The free cytoplasmic [NADP(+)]/[NADPH] ratio in liver decreases immediately after ethanol administration but returns nearly to control values after 15min. 4. The cytoplasmic [ATP]/[ADP][HPO(4) (2-)] ratio is elevated 15min after ethanol administration in the starved rat. 5. The rapid and large changes in most metabolite concentrations measured appeared to result from the maintenance of near-equilibrium in a wide interlinked network. 6. Differences between fed and starved rats 15min after ethanol administration were slight. PMID- 4342560 TI - Effects of some adrenocorticotrophin analogues on protein synthesis in brain. PMID- 4342559 TI - Pathways of malate oxidation in isolated plant mitochondria. PMID- 4342562 TI - [Results of a serologic study on 356 patients suffering from dracunculosis carried out by means of the indirect fluorescent antibody technic]. PMID- 4342561 TI - [The 7th cholera pandemia (1961-1966, 1970)]. PMID- 4342563 TI - [5 new serotypes of Salmonella of African origin]. PMID- 4342564 TI - [Histological identification of a cytomegalovirus endocervicitis in a Laotian woman during the 5th month of pregnancy]. PMID- 4342565 TI - [Frequency of trepanomatoses in Baoule on the Ivory Coast]. PMID- 4342566 TI - [Prostaglandins]. PMID- 4342567 TI - [Existence of false positive angiographic picture of nesidioma of the pancreas?]. PMID- 4342568 TI - [Steroids. 32. Stereospecific preparation of nitrogen-containing steroids from aziridines and vicinal azidoalcohol mesylates]. PMID- 4342570 TI - [Enzyme activities and bone metastasizing in prostatic carcinoma]. PMID- 4342569 TI - Errors in the diagnosis of Wilms' tumors. PMID- 4342571 TI - The treatment of herpetic stromal disease. PMID- 4342572 TI - [The radiological analysis of the Budd-Chiari syndrome]. PMID- 4342573 TI - [Angiographic findings in inflammatory intracranial processes]. PMID- 4342574 TI - [Angiographic examinations of spinal vascular abnormalities]. PMID- 4342575 TI - [Animal experiments in renal venography using a nonrenotrophic contrast medium]. PMID- 4342576 TI - [The effect of the patient's position in uterine phlebography. A comparison of supplementary methods]. PMID- 4342577 TI - [The phlebographic demonstration of venous aneurysms]. PMID- 4342578 TI - [Clinical aspects of functional small bowel insufficiency in regional Crohn's enteritis]. PMID- 4342579 TI - [Information content of radiological signs of malignant and benign lesions of the breast in the mammogram]. PMID- 4342580 TI - [Considerations regarding optimal mammography techniques]. PMID- 4342581 TI - [Generalized dysplasia of epiphyseal and metaphyseal exostoses in the Rubinstein Taybi syndrome]. PMID- 4342582 TI - [Clinical and radiological features of solitary plasmacytomas]. PMID- 4342583 TI - [Atypical radiological findings in osteo-myelo-sclerosis]. PMID- 4342584 TI - [Hyperostosis of the heads of the ribs, a feature of perivertebral hyperostosis]. PMID- 4342585 TI - [Cortical hypertrophy of isolated ribs due to functional causes]. PMID- 4342586 TI - [Atypical changes in the wrist in workmen using compressed air equipment]. PMID- 4342587 TI - [Diaphyseal cuffing of the proximal phalanges of the toes. (Special, frequently ignored radiological findings in the supportive tissues 4)]. PMID- 4342588 TI - [Scintigraphic progress observations before and after alloplastic hip joint prosthesis]. PMID- 4342590 TI - [Neurinoma of the esophagus]. PMID- 4342589 TI - [Calcification in male breast carcinoma]. PMID- 4342591 TI - [Intraluminal duodenal diverticulum]. PMID- 4342592 TI - [Tumor-like Bauhin's valve]. PMID- 4342593 TI - [Chemical changes in the tension of collagen fibers]. PMID- 4342594 TI - Enzyme patterns in young and old mouse livers and lungs. PMID- 4342595 TI - [Ovarian thecoma in an 11-year-old girl (or feminizing thecal cell ovarian dystrophy)]. PMID- 4342596 TI - Electron paramagnetic resonance study of thermal decomposition of molecules. I. Barbituric acid derivatives. PMID- 4342597 TI - Flexibility and conformations of guanosine monophosphates by the Overhauser effect. PMID- 4342598 TI - Studies on cytochrome oxidase. 8. Preparation and some properties of cardiac cytochrome oxidase. PMID- 4342599 TI - Studies on cytochrome oxidase. IX. Heme-copper interaction. PMID- 4342600 TI - Muscle differentiation in cell culture. Effects of nucleoside inhibitors and Rous sarcoma virus. PMID- 4342601 TI - Metabolism of gallic acid and syringic acid by Pseudomonas putida. PMID- 4342602 TI - Proteins of the thermophilic fungus Humicola lanuginosa. I. Isolation and amino acid sequence of a cytochrome C. PMID- 4342604 TI - Xylosyltransferases in Cryptococcus laurentii. PMID- 4342603 TI - Purification and properties of sulfite oxidase from chicken liver. Presence of molybdenum in sulfite oxidase from diverse sources. PMID- 4342605 TI - The enzymatic characteristics and the control of glycogen phosphorylase during early amphibian development. PMID- 4342607 TI - Characterization of the interaction of a protein inhibitor with adenosine 3',5' monophosphate-dependent protein kinases. I. Interaction with the catalytic subunit of the protein kinase. PMID- 4342606 TI - Effects of heparin on lipoprotein lipase from bovine milk. PMID- 4342608 TI - Role of enzyme-enzyme interactions in the regulation of gluconeogenesis. Properties and subunit structure of fructose 1,6-diphosphatase from swine kidney. PMID- 4342609 TI - Radioimmunoassay of human collagenase. Specificity of the assay and quantitative determination of in vivo and in vitro human skin collagenase. PMID- 4342610 TI - The behavior of DNA on basic polyamino acid Kieselguhr columns. PMID- 4342612 TI - Selective medium for the isolation of bordetella pertussis and parapertussis. PMID- 4342611 TI - A 'virus-free' cell line derived from a patient with infectious mononucleosis. AB - A continuous cell culture line, derived from a nurse with infectious mononucleosis, is described. Electron microscopic and immunofluorescent examination suggested that it was substantially free from detectable complete virus particles, although the presence of a soluble complement-fixing antigen showed the persistence of other antigenic components of the EB virus. PMID- 4342613 TI - Organ cultures of normal, dysplastic, hyperplastic, and neoplastic human mammary tissues. PMID- 4342614 TI - Transformation of a rat epithelial-like cell line by murine sarcoma virus. PMID- 4342615 TI - Immunofluorescence tests for antibodies to Epstein-Barr virus with sera of lower primates. PMID- 4342616 TI - Tumor induction in squirrel monkeys by the ST strain of feline sarcoma virus. PMID- 4342617 TI - Tumors in the duck (family Anatidae): a review. PMID- 4342618 TI - Rapid development of bronchiolo-alveolar squamous cell tumors in rats after intratracheal injection of 3-methylcholanthrene. PMID- 4342619 TI - Patterns of glucose metabolism in normal and virus-transformed chick cells in tissue culture. PMID- 4342620 TI - Activation of guinea pig C-type virus in cultured spleen cells by 5-bromo-2' deoxyuridine. PMID- 4342621 TI - Heterochromatin, satellite DNA, and transformed neoplastic cells. PMID- 4342622 TI - De novo synthesis of transfer and 55 RNA 1f in cleaving sea urchin embryos. PMID- 4342623 TI - Water-soluble insulin receptors from human lymphocytes. AB - Specific insulin receptors from human lymphocytes in culture have been prepared in aqueous solution without use of detergents or related compounds. Receptors prepared in this fashion exhibit characteristics identical to those reported in intact cells. PMID- 4342624 TI - [Determination of alpha-1-fetoprotein in a virilizing tumor of the liver]. PMID- 4342625 TI - [Anaerobic infection following World War II]. PMID- 4342626 TI - [Histochemical characteristics of cervical cancer]. PMID- 4342627 TI - [Electron-histochemical study of the ATPase activity in isolated cell nuclei of hepatomas]. PMID- 4342628 TI - [Metabolism of carcinogenic hydrocarbons in tumor cell cultures]. PMID- 4342629 TI - [Immunity in transplantation of rat ascitic tumors in mice]. PMID- 4342630 TI - [Spontaneous neoplasms in monkeys]. PMID- 4342631 TI - [Vitamin-3 administration to infants raised in institutions]. PMID- 4342632 TI - [Paraneoplastic syndrome]. PMID- 4342633 TI - [Restriction and modification of phage r by Clostridium perfringens NCTC 8798 and its mutants]. PMID- 4342634 TI - [Removal of nonspecific inhibitors of the influenza A 2 -Hong Kong-1-68 strain (comparative study of treatment with KIO 4 and cholera filtrate)]. PMID- 4342635 TI - [A true jugular glomus]. PMID- 4342637 TI - [Bone maturation during puberty. Apropos of 227 adolescents from Dakar]. PMID- 4342636 TI - [Angiography in abdominal visceral injuries. Attempt at schematic radiologic semiology]. PMID- 4342638 TI - Lobular carcinoma--an indication for elective biopsy of the second breast. PMID- 4342639 TI - Mammalian behavior and the adrenal cortex. A review. PMID- 4342640 TI - Blood nucleoside and nucleotide studies in mental disease. PMID- 4342641 TI - The management and nature of depressive illnesses in late life: a follow-through study. PMID- 4342642 TI - Chronic hepatitis. PMID- 4342643 TI - Control of hepatitis in dialysis units. PMID- 4342644 TI - [Analogues of adenosine 3',5'-cyclic phosphate containing nitrogen and sulphur in the phosphate ring]. PMID- 4342646 TI - A twelve month review of the aftercare clinic activities in Barrow and Walton counties. PMID- 4342647 TI - [Distribution of pig enteroviruses on farms of the Ukrainian Poles's zone]. PMID- 4342648 TI - [Use of concentrated and purified enterovirus antigens for the study of the etiology of neuroviral diseases]. PMID- 4342645 TI - The inclusion bodies in granular pneumonocytes of hamster lung: a combined cytochemical and ultrastructural study. PMID- 4342649 TI - Cyclic AMP released by rat testis during gonadotrophin stimulation in vitro. PMID- 4342650 TI - Susceptibility of "Pseudomonas aeruginosa" to combinations of antibiotics. PMID- 4342651 TI - [Contribution of in vitro culture to the study of cerebral tumors]. PMID- 4342652 TI - [Hypophyseal tumors in the records of the department of radiotherapy in the years 1959-1969]. PMID- 4342653 TI - [Clinical picture and therapy of virus diseases of the cornea]. PMID- 4342654 TI - [Statistic of prostatic carcinoma in biopsy material]. PMID- 4342655 TI - [Glycolysis in different fractions of chick brain tissue during embryonic development]. PMID- 4342656 TI - [Effect of polyelectrolytes on virus reproduction]. PMID- 4342657 TI - [Dynamics of adenovirus reproduction in the liver of newborn hamsters and changes in humoral immunity factors in experimental adenovirus hepatitis]. PMID- 4342658 TI - [Elimination of resistance of transformed cells in mixed infection]. PMID- 4342659 TI - [Physicochemical characteristics of rhinovirus and its RNA]. PMID- 4342661 TI - [Effect of diethylaminoethyl-dextran on the antiviral activity of polyinosinic polycytidylic acid complex in tissue culture]. PMID- 4342660 TI - [Isolation of cytomegalovirus of green monkeys from cultures of kidney tissues of clinically healthy monkeys]. PMID- 4342663 TI - [Latent ectromelia virus carrier state in mice of BALB-c line]. PMID- 4342662 TI - [Isolation of cytomegalovirus from sick children and study of its biological properties]. PMID- 4342664 TI - [Effect of DEAE-dextran and dimethyl sulfoxide on the results of titration of parainfluenza, respiratory syncytial and rhinoviruses in cell culture]. PMID- 4342665 TI - On the local responses of the cerebellar cortex. PMID- 4342666 TI - Effect of testosterone, dexamethasone and hypophysectomy on membranous whorls in the adrenal gland of the Mongolian gerbil. PMID- 4342667 TI - [Acute effect of ACTH administered in vivo on the 11-beta-hydroxylase activity of rat adrenal gland homogenates]. PMID- 4342668 TI - [Genetic considerations on a series of cases of peripheral neuropathy of the hereditary paramyloidosis type]. PMID- 4342669 TI - [Effect of various buffer systems on the thiamine pyrophosphate destruction by rat liver homogenates]. PMID- 4342670 TI - E.B. virus and multiple sclerosis. PMID- 4342671 TI - Influence of carbon monoxide upon some respiratory enzymes of the chick embryo. PMID- 4342672 TI - The transient nature of angiotensin-induced natriuresis in the rabbit. PMID- 4342673 TI - The distribution and storage of vitamin D and its metabolites in human tissues. PMID- 4342675 TI - [Clinical features and prognosis of carcinoma of the colon and rectum]. PMID- 4342676 TI - [Thyroid hormones following iodine isotope therapy]. PMID- 4342674 TI - Effect of catecholamines and other vasoactive substances on superficial hand veins in man. PMID- 4342678 TI - Method for determination of acid amyloglucosidase in isolated islets of the pancreas. PMID- 4342677 TI - Study of respiratory chain in small amounts of biological materials. II. Involvement of exogenous cytochrome C in the oxidation of ascorbic acid in the terminal segment of the respiratory chain. PMID- 4342679 TI - The distribution of aspartate aminotransferases in normal and neoplastic rat and mouse tissue. PMID- 4342680 TI - Inhibitory postsynaptic potentials of hypoglossal motoneurons of the cat. PMID- 4342681 TI - Synaptic activity in alpha motoneurons consequent to their motor unit contractions. PMID- 4342682 TI - A comparison of isometric contractions of the whole muscle with those of motor units in a fast-twitch muscle of the cat. PMID- 4342683 TI - Neurochemical changes in the offspring of rats subjected to stressful conditions during gestation. PMID- 4342685 TI - The solution conformation of the ferrichromes. II. Proton magnetic resonance of metal-free ferricrocin and ferrichrysin, conformational implications. PMID- 4342684 TI - Classification of cell types: agglutination and chromosomal properties. PMID- 4342686 TI - Attempts to produce urinary bladder cancer in dogs by inoculation of simian virus 40 into the urothelium. PMID- 4342689 TI - Canine embryonal nephroma: a case report. PMID- 4342688 TI - Serum minerals, leukocyte profiles, and plasma corticoids in dairy heifers after an injection of corticotropin. PMID- 4342690 TI - Postprandial drowsiness. PMID- 4342687 TI - A scanning electron microscope study of siliceous urinary calculi from cattle. PMID- 4342691 TI - Progress maintained in molecular biology. PMID- 4342692 TI - Transformation of mouse cells infected with AKR leukaemia virus induced by smog extracts. PMID- 4342693 TI - Rat C-type virus induced in rat sarcoma cells by 5-bromodeoxyuridine. PMID- 4342694 TI - The murine leukemias. PMID- 4342695 TI - [Oxidated and reduced nicotinamide coenzyme and -glycerophosphate in myocardium and aorta in experimental arteriosclerosis]. PMID- 4342696 TI - [The effect of exogenous cytochrome C on the oxidation of pyridine nucleotides by liver mitochondria in albino rats of various ages]. PMID- 4342697 TI - [Hexokinase and glucokinase activity in human and animal tumors]. PMID- 4342698 TI - [The phospholipid composition of the dystrophic myocardium]. PMID- 4342699 TI - [Comparison of methodological approaches to study of the nervous tissue using electron cytochemistry]. PMID- 4342700 TI - [Ultrastructure of skeletal muscles in dystrophia myotonica]. PMID- 4342701 TI - [Principles of the use of electroencephalographic data in the complex development of histostructural diagnoses of tumors in the cerebral hemispheres]. PMID- 4342702 TI - [Effect of angiotensin on adrenergic transmission]. PMID- 4342703 TI - Pancreatic islet beta cell tumors and hyperplasia: experience in 14 Seattle hospitals. PMID- 4342704 TI - Autotrophy: concepts of lithotrophic bacteria and their organic metabolism. PMID- 4342705 TI - Mechanism of cell transformation by RNA tumor viruses. PMID- 4342706 TI - [Uveitis treatment]. PMID- 4342707 TI - Cyclic AMP-dependent protein kinases of bovine epididymal spermatozoa. PMID- 4342708 TI - Nucleotide composition of the RNA from RD-114 virions. PMID- 4342709 TI - Spin exchange of spin labeled probes in a natural membrane. PMID- 4342710 TI - The pleiotypic response in mammalian cells: search for an intracellular mediator. PMID- 4342711 TI - Biosynthetic synthesis and isolation of phospholipid spin-labels from rat liver microsomes and mitochondria. PMID- 4342712 TI - Binding of radioactively labeled concanavalin A and Ricinus communis agglutinin to rat liver- and rat ascites hepatoma-nuclei. PMID- 4342713 TI - Divergent action of cAMP and dibutyryl cAMP on macromolecular synthesis in HeLa S3 cultures. PMID- 4342714 TI - On the structure and function of nitrogenase from Clostridium pasteurianum W5. PMID- 4342715 TI - Electron paramagnetic resonance spectra of some active cobalt(II) substituted metalloenzymes and other cobalt(II) complexes. PMID- 4342716 TI - A reversal of heme crevice strengths of ferri- and ferrocytochrome c on carboxymethylation. PMID- 4342717 TI - The in vivo stimulation of rat liver ornithine decarboxylase activity by dibutyryl cyclic adenosine 3',5'-monophosphate, theophylline and dexamethasone. PMID- 4342718 TI - Rapid reciprocal changes of hepatic glycolytic enzymes and fructose-1,6 diphosphatase following glucagon and insulin injection in vivo. PMID- 4342719 TI - Changes in acyl group composition of phospholipids from chicken embryonic fibroblasts after transformation by Rous sarcoma virus. PMID- 4342720 TI - Characterization of a new photo-ESR signal associated with photosynthesis. PMID- 4342721 TI - In vitro stimulation of gluconeogenesis from pyruvate and of 14 CO 2 -fixation by dexamethasone phosphate and vasopressin in the kidney cortex of adrenalectomized rats. PMID- 4342722 TI - Indirect electrochemical titration of beef heart cytochrome c oxidase. PMID- 4342723 TI - Association of poly ADP-ribose glycohydrolase with liver chromatin. PMID- 4342725 TI - The ascorbate reduction of denatured ferricytochrome c. PMID- 4342724 TI - Identification of the lipid-binding cyanogen bromide fragment from the cystine containing high density apolipoprotein, APOLP-GLN-II. PMID- 4342726 TI - The pyridine nucleotide cycle: presence of a nicotinamide mononucleotide-specific glycohydrolase in Escherichia coli. PMID- 4342727 TI - Effect of protein binding on phospholipase C hydrolysis of aqueous phospholipid dispersions. PMID- 4342728 TI - Interaction of calcium with microsomes: a modified method for the rapid isolation of rat liver microsomes. PMID- 4342729 TI - Studies on site I phosphorylation, EPR detectable iron-sulfur proteins and piericidin A sensitivity in the in vivo induction system of Candida utilis cells. PMID- 4342730 TI - Oxidation-reduction potentials of the electron acceptors in laccases and stellacyanin. PMID- 4342732 TI - [Renin-angiotensin system in the diagnosis of renovascular hypertension. Radioimmunoassay of angiotensin I and angiotensin II]. PMID- 4342731 TI - Atypical erythrokeratoderma with deafness, physical retardation and peripheral neuropathy. PMID- 4342734 TI - Mysterious sudden death. PMID- 4342733 TI - Predicting survival following surgery for bronchogenic carcinoma. PMID- 4342736 TI - [Unusual localization of glomangioma. Synonyms: glomic tumor; painful subcutaneous tubercle; angioneuroma; angioneuromyoma; neuro-myo-arterial glomus]. PMID- 4342735 TI - Hypercorticosteroidism with pulmonary and bone lesions. PMID- 4342740 TI - [The axo-somatic synaptic terminals on the fresh water gastropode Planorbus corneus neirones]. PMID- 4342741 TI - Induced variations in microorganisms. II. The mutagenic effect of ethyl methanesulfonate on Rhizobium trifolii. PMID- 4342742 TI - The peripheral nerve repair. A review. PMID- 4342743 TI - Token economy programs in the treatment of hospitalized adult psychiatric patients. Current status and recent trends. PMID- 4342744 TI - Prescribing the pill. PMID- 4342747 TI - Viral etiology of ascending myelitis. PMID- 4342746 TI - Observation of dividing spermatocytes for chromosome aberrations induced in mouse spermatogonia by chemical mutagens. PMID- 4342745 TI - In-vitro induction of meiotic division in follicle-enclosed rat oocytes by LH, cyclic AMP and prostaglandin E 2 . PMID- 4342749 TI - [Studies of endoneoplastic transformation of gliomas in long-term cultures and subcultures in vitro]. PMID- 4342748 TI - Chemical carcinogenesis in mice inhibited by interferon. PMID- 4342750 TI - [Viral etiology of multiple sclerosis. Possible responsibility of para-influenza virus type I]. PMID- 4342751 TI - Solid tumours in children. PMID- 4342752 TI - Herpesvirus hominis: isolation from human trigeminal ganglion. AB - Herpesvirus hominis was isolated from the trigeminal ganglion obtained at autopsy from 1 of 22 patients with no clinical evidence of active herpetic disease, and from one patient with malignant lymphoma who died with herpes zoster on the abdomen, pulmonary cytomegalic inclusion disease, and possible oral herpes simplex. Virus was isolated by cocultivation of explants of ganglion with monolayers of Vero green monkey kidney cells and required 3 weeks of culture before viral cytopathic effects were evident. These observations support the concept that latent infection of sensory ganglia may be the source of virus in recurrent herpetic disease in man. PMID- 4342753 TI - Phosphoenolpyruvate carboxykinase. I. Its role in gluconeogenesis. PMID- 4342754 TI - Review: relationships of copper and molybdenum to iron metabolism. PMID- 4342755 TI - [Evaluation of fluphenazine use since establishment of a psychiatric section]. PMID- 4342756 TI - [Preservation of an error of metabolism (Niemann-Pick disease) in a long term culture of hepatic parenchymal cells]. PMID- 4342757 TI - On the conformation change attending the hydration of lyophilized cytochrome c. PMID- 4342758 TI - Synthetic peptides related to the entire sequence of yeast iso-1-cytochrome C. PMID- 4342759 TI - Diabetic neuropathy. PMID- 4342760 TI - Plasma levels and therapeutic effect of 25-hydroxycholecalciferol in epileptic patients taking anticonvulsant drugs. AB - Plasma levels of 25-hydroxycholecalciferol (25-HCC) were measured by a specific competitive protein-binding assay. Mean levels in both normal London adults and adolescent schoolchildren were 16 ng/ml and the mean level in a group of epileptic patients on high-dosage anticonvulsant therapy was 5 ng/ml, (difference from normals P < 0.001). Two further epileptic patients, with well-marked anticonvulsant osteomalacia, were treated with small doses of 25-HCC during full metabolic balance studies; rapid healing followed administration of 25-HCC by mouth in doses of 10-45 mug daily, which is well below the effective dose range of calciferol in this condition. These findings provided further evidence that anticonvulsant osteomalacia results from hepatic enzyme induction which, by increasing the metabolism of cholecalciferol to inactive compounds, lowers 25-HCC levels in patients whose dietary vitamin D intake and exposure to sunlight are otherwise adequate. Results also indicated that under certain circumstances 25 HCC may have considerably stronger antirachitic potency in man than has hitherto been recognized. PMID- 4342761 TI - Spontaneous rupture of hepatocellular carcinoma. AB - Forty-two cases of ruptured hepatoma with intra-abdominal haemorrhage were seen over a period of eight years in the professorial surgical unit at the Queen Mary Hospital, Hong Kong. In all, 207 cases of liver cancer were seen during this period, giving an incidence of rupture of 14.5%. There were 37 men and five women. The clinical features were the sudden onset of pain with shock and the presence of blood in the peritoneal cavity. The diagnosis was made before operation on suspicion and by a process of elimination. In cases of doubt paracentesis abdominis was performed to determine whether there was blood in the peritoneal cavity. Treatment was directed to control of haemorrhage and resection.The prognosis, although extremely poor, is no worse than the hepatocellular carcinoma that has not ruptured. There was one long-term survivor a patient who had undergone an extensive resection. The man was alive and well after more than five years. PMID- 4342763 TI - Leucocytosis after tetracosactrin. PMID- 4342762 TI - Primary hepatoma and hepatitis-associated antigen in a young white woman. AB - A young woman whose serum was positive for hepatitis-associated antigen (H.A.A.) and alpha-fetoprotein developed a malignant hepatoma. Though the light microscopical appearances of the surrounding liver tissue were normal, electronmicroscope examination of the tumour tissue disclosed both C-virus-like particles and H.A.A. particles. Possibly there was a causal connexion between one of these particles and the hepatoma. PMID- 4342764 TI - Reversal of adult mental subnormality. PMID- 4342765 TI - [Influence of angiotensin on the excretion of vanilmandelic acid in patients with juvenile hypertension]. PMID- 4342766 TI - [After care in gastrointestinal tract carcinomas]. PMID- 4342768 TI - Synovioma in a cat. PMID- 4342767 TI - [Early diagnosis of biliary Clostridium welchii during cholecystectomy]. PMID- 4342769 TI - Sudden deafness and its several treatments. PMID- 4342770 TI - The curative, palliative, and adjunctive uses of cryosurgery in the head and neck. PMID- 4342771 TI - Neurogenic tumors of the parapharyngeal space. PMID- 4342772 TI - [Socio-therapeutic and social medicine importance of the day clinic. Critical study on the defective treatment and after care of mental patients in the present hospital structure and the need for reform]. PMID- 4342774 TI - Advances in management of malignant solid tumors in children. PMID- 4342773 TI - [Etiopathogenesis, diagnosis and treatment of renovascular hypertension]. PMID- 4342775 TI - [The development of rickets and air pollution]. PMID- 4342776 TI - Urinary hydroxyproline, serum alkaline phosphatase, calcium and phosphorus in patients with bone neoplasms. PMID- 4342777 TI - Phosphatases of leukocytes. II. Isolation and characterization of acid phosphatase of normal leukocytes and leukocytes from patients with chronic granulocytic leukemia. PMID- 4342778 TI - Activity of serum aminotransferases and phosphatases, and prothrombin level after experimental hemorrhage. PMID- 4342779 TI - [Cystosarcoma phyllodes of the breast--conservative procedures or amputation?]. PMID- 4342780 TI - [Effect of experimental shock on the activity of some enzymes and electrolyte metabolism in internal organs]. PMID- 4342781 TI - [Side effects and toxic action of anti-epileptic drugs]. PMID- 4342782 TI - Advances in neurology. PMID- 4342783 TI - [Two cases of infrequent tumors of the pinna (leiomyosarcoma and histiocytofibroma)]. PMID- 4342785 TI - HL-A typing of cultured peripheral lymphoblastoid cells. PMID- 4342784 TI - [Chronological course of the effect of thyroid hormones and goitrogens on the accumulation of radioactive iodine in the rat]. PMID- 4342786 TI - [Phosphoprotein phosphatase of muscles of different animal species]. PMID- 4342787 TI - [Methods for the determination of nicotinic acid derivatives in biological products]. PMID- 4342788 TI - [Stereodirection of NAD biosynthesis in rat liver]. PMID- 4342790 TI - Experimental study on the neuromuscular blocking action of procaine amide. PMID- 4342789 TI - [Age factors in the absorption of exogenous cytochrome C by rat liver mitochondria]. PMID- 4342791 TI - [Molecular organicity of abnormal behaviors and mental disorders]. PMID- 4342793 TI - The influence of environment on parainfluenza 3 virus and its replication in tissue cultures. PMID- 4342792 TI - Indication of selective hepatic angiography. PMID- 4342794 TI - Muscle rigidity in a newborn due to continuous peripheral nerve hyperactivity. PMID- 4342795 TI - Palatal myoclonus associated with abnormal ocular and extremity movements. A polygraphic study. PMID- 4342796 TI - Diphenylhydantoin-induced cerebellar degeneration. PMID- 4342797 TI - Engrafted human bone marrow and blood cells in culture. PMID- 4342799 TI - Primary cancer of the liver following treatment of polycythaemia vera with radioactive phosphorus. PMID- 4342800 TI - Therapeutic irradiation of the liver. PMID- 4342801 TI - Modification of radiation sensitivity by post-irradiation thermal annealing of free radicals. PMID- 4342798 TI - Mammary duct injection in patients with nipple discharge. PMID- 4342802 TI - [Effect of radioiodination on biological properties of certain proteins]. PMID- 4342803 TI - Hospital infections. PMID- 4342804 TI - [Polymyositis--electron microscopic biopsy findings in 12 cases]. PMID- 4342805 TI - The frequency of the red cell NADH diaphorase Dia allele in Sardinia. PMID- 4342807 TI - Mid-America bone diagnostic center, University Medical Center, Columbia, Missouri. PMID- 4342806 TI - New observations on the anatomical features of the female genitalia. PMID- 4342808 TI - Therapeutic abortion: middle-class privilege or curse? PMID- 4342809 TI - Congenital toxoplasmosis. PMID- 4342810 TI - Disseminated toxoplasmosis in a liver transplant patient. PMID- 4342811 TI - Observations on the post-transcriptionally modified nucleotides in the 16S ribosomal ribonucleic acid. AB - The 16S (18S) ribosomal ribonucleic acids from a number of organisms were screened for the presence of (some of) the post-transcriptionally modified oligomers found in Escherichia coli 16S ribosomal ribonucleic acid. All prokaryotic 16S species contained all of the modified oligomers tested, with the sole exception that one such oligomer was missing in Alcaligenes faecalis. The post-transcriptional modifications in all of these oligomers except one appear to occur at the later stagesin ribosomal maturation. PMID- 4342812 TI - Analysis of ribosomes from viomycin-sensitive and -resistant strains of Mycobacterium smegmatis. AB - Viomycin-resistant strains were isolated from Mycobacterium smegmatis. Ribosomes were isolated and tested for drug resistance in subcellular systems containing poly(U) as messenger ribonucleic acid. Resistance to viomycin in these strains was due to altered ribosomes. Further analysis showed that viomycin resistance of two mutants with low level resistance (20 mug/ml) was due to altered 30S ribosomal subunits. Another mutant that was highly resistant to viomycin (1 mg/ml), however, had altered 50S ribosomal subunits. PMID- 4342813 TI - Klebsiella aerogenes strain carrying drug-resistance determinants and a lac plasmid. AB - In addition to carrying determinants conferring resistance to at least two antibiotics, chloramphenicol and streptomycin, a Klebsiella aerogenes strain contains a plasmid responsible for increased beta-galactosidase activity. The plasmid can be transferred to Escherichia coli and Salmonella typhimurium strains. K. aerogenes segregants without the plasmid grow on lactose one-half as fast as the parent strain and contain only one-tenth to one-fifth as much beta galactosidase. PMID- 4342814 TI - Inhibition of isocitrate lyase: the basis for inhibition of growth of two Arthrobacter species by pyruvate. AB - Growth of Arthrobacter atrocyaneus and A. pyridinolis on certain growth substrates was found to be inhibited by pyruvate and compounds which can be converted to pyruvate. Growth of A. atrocyaneus on acetate, for example, was completely inhibited by 5 mm pyruvate; growth of this organism on glucose was less sensitive and growth on succinate was insensitive to inhibition by pyruvate. Growth of a third Arthrobacter species, A. crystallopoietes, on acetate and other substrates was not inhibited by pyruvate. The site of pyruvate inhibition was shown to be the isocitrate lyase reaction. Glyoxylate, which affords a bypass of this reaction, restored the ability of A. atrocyaneus to evolve (14)CO(2) from acetate in the presence of pyruvate. The isocitrate lyases from A. atrocyaneus and A. pyridinolis were competitively inhibited by concentrations of pyruvate as low as 1 mm, whereas the enzyme from A. crystallopoietes was unaffected by this concentration of pyruvate. Comparable levels of phosphoenolpyruvate did not inhibit the isocitrate lyases from any of the species. A mutant strain of A. atrocyaneus, PW11, which is deficient in isocitrate lyase activity, grew on glucose at a reduced rate that was comparable to the rate of growth of the wild type strain on glucose plus lactate. Addition of lactate to PW11 did not further reduce its rate of growth on glucose. Thus, the glyoxylate pathway appears to be used as an anaplerotic pathway during growth of A. atrocyaneus on glucose. Two other considerations suggest that A. atrocyaneus and A. pyridinolis, but not A. crystallopoietes, may be deficient in the ability to convert pyruvate to 4-carbon acids. First, the former two species accumulate intracellular pyruvate from exogenous l-alanine to a much greater extent than does A. crystallopoietes. Moreover, A. atrocyaneus and A. pyridinolis are incapable of growth on lactate as sole source of carbon whereas A. crystallopoietes can grow on lactate. PMID- 4342815 TI - Evidence against the presence of 3',5'-cyclic adenosine monophosphate and relevant enzymes in Lactobacillus plantarum. AB - Analysis of cells of Lactobacillus plantarum, starved or undergoing induction, showed no 3', 5'-cyclic adenosine monophosphate (cAMP). Neither adenyl cyclase nor 3', 5'-cAMP phosphodiesterase was detected in extracts. Extracts of L. plantarum did not inhibit these two enzymes of Escherichia coli K-12, strain W1435. Incubation of adenosine triphosphate (ATP)-U-(14)C with cells or various cell-free fractions of L. plantarum did not produce labeled 3', 5'-cAMP. Of various 3', 5'-cyclic and acyclic nucleotides tested, only 3', 5'-cAMP, ATP, and yeast adenylic acid stimulated l-arabinose isomerase. Yeast adenylic acid was two to four times as effective as 3', 5'-cAMP or ATP. 2', 3'-cAMP was not effective. PMID- 4342816 TI - Inositol phosphate phosphatases of microbiological origin: the inositol pentaphosphate products of Aspergillus ficuum phytases. AB - The fungus Aspergillus ficuum NRRL 3135 is known to produce an extracellular nonspecific orthophosphoric monoester phosphohydrolase (EC 3.1.3.2) with a pH optimum of 2.0, as well as an extracellular myo-inositol hexaphosphate phosphohydrolase (EC 3.1.3.8; phytase) with pH optima of 2.0 and 5.5. Both these enzymes are also known to hydrolyze myo-inositol hexaphosphate. The pentaphosphates liberated in the first step of this hydrolysis have been isolated and identified by ion-exchange chromatography and optical rotation. The nonspecific orthophosphoric monoester phosphohydrolase produces a single pentaphosphate, d-myo-inositol-1,2,4,5,6-pentaphosphate, whereas the phytase, at both pH 2.0 and 5.5, produces a mixture of two pentaphosphates. The major component of this mixture is d-myo-inositol-1,2,4,5,6-pentaphosphate and the other is d-myo-inositol-1,2,3,4,5-pentaphosphate. Thus the pathways of dephosphorylation of myo-inositol hexaphosphate by these two enzymes differ from that of wheat-bran phytase which forms l-myo-inositol-1,2,3,4,5-pentaphosphate. PMID- 4342817 TI - Reconstitution of Micrococcus lysodeikticus reduced nicotinamide adenine dinucleotide and L-malate dehydrogenases with dehydrogenase-depleted membrane residues: a basis for restoration of oxidase activities. AB - Deoxycholate disruption of Micrococcus lysodeikticus protoplast membranes resulted in solubilization of both l-malate and reduced nicotinamide adenine dinucleotide (NADH) dehydrogenase enzymes (substrate: 2,6 dichlorophenolindophenol oxidoreductases). Insoluble residues contained cytochromes of the b, c, and a type. Solubilized dehydrogenases were reconstituted with insoluble residues by treatment of disrupted membranes with magnesium ions. Most of the solubilized l-malate and NADH dehydrogenase activities were precipitated by magnesium ions independent of enzyme reconstitution with insoluble residues. Reconstituted dehydrogenases explained the mechanism for restoration of disrupted l-malate and NADH oxidase activities (4). Black light irradiation inhibited oxidase activities of both native and reconstituted membranes. These irradiated membrane oxidases were partially restored by exogenous napthoquinones [K(2(20)) and K(2(50))] but not by CoQ((6)). Reconstitution experiments showed that native membrane napthoquinone was retained in the insoluble residues of deoxycholate-disrupted membranes. PMID- 4342819 TI - Electron microscopic studies of the anterior pituitaries and adrenal cortices of normal and anencephalic human fetuses. PMID- 4342818 TI - A salt-inhibited cytochrome c reductase obtained from the moderately halophilic bacterium, Micrococcus halodenitrificans. AB - A membrane-bound cytochrome c reductase from Micrococcus halodenitrificans was inhibited by NaCl at concentrations as low as 0.05 m. The inhibition was competitive with respect to cytochrome c and noncompetitive with respect to reduced nicotinamide adenine dinucleotide. Thus the effect of NaCl was to increase the apparent K(m) of the enzyme for cytochrome c and not to inhibit the intrinsic activity of the enzyme. PMID- 4342820 TI - Mechanism of the restricted growth of herpes simplex virus type 2 in a hamster cell line. PMID- 4342821 TI - Ultraviolet irradiation of herpes simplex virus: reactivation processes and delay in virus multiplication. PMID- 4342822 TI - A specific inhibitor of polyoma virus in infected rat and hamster cells and in transformed clones of hamster cells. PMID- 4342823 TI - Serological relationships between different strains of vesicular stomatis virus. PMID- 4342824 TI - Fate of virus DNA in the abortive infection of human lymphoid cell lines by Epstein-Barr virus. PMID- 4342825 TI - Properties in cell cultures of a hamster brain-adapted subacute sclerosing panencephalitis virus. PMID- 4342827 TI - Production of interferon in rabbit cell cultures by mouse L cell-bound poly(rI).poly(rC). PMID- 4342826 TI - The fate of vesicular stomatitis virus in cultured chick embryo cells. PMID- 4342828 TI - CPK activity in hypoparathyroidism. PMID- 4342829 TI - Positive contrast ventriculography--a comparison between Conray (methylglucamine lothalamate 60 per cent) and Pantopaque (di-iodophenyl undecylate). PMID- 4342830 TI - [Prognosis in Hodgkin's disease]. PMID- 4342831 TI - Chlormethiazole, sleep, and drug withdrawal. PMID- 4342832 TI - Chronic schizophrenia and discharge from hospital. PMID- 4342833 TI - [Pigmented villo-nodular synovitis with bone lesion]. PMID- 4342834 TI - [Surgery of insulomas]. PMID- 4342835 TI - Histogenesis of ovarian epithelial tumors; introducing a new group--"gonado nephric tumors". PMID- 4342836 TI - Steroid-protein interactions. XXV. Binding of progesterone and cortisol in pregnancy sera; progesterone-binding globulin and uterine cytosol receptor in the pregnant guinea pig. PMID- 4342837 TI - The metabolic effects of halothane on mammalian hepatoma cells in vitro. I. Inhibition of cell replication. PMID- 4342838 TI - [Effect of various drugs on collagen biosynthesis and cytotoxicity. Study on calf embryo fibroblast cultures]. PMID- 4342839 TI - The malignant potential of bronchial adenoma. PMID- 4342840 TI - Primary malignant tumors of the mediastinum. PMID- 4342841 TI - Pathology of exfoliated oropharyngeal epithelial cells infected with wild-type adenovirus. AB - Adenovirus disease was diagnosed in 2 hr by staining exfoliated infected oropharyngeal cells with fluorescein-tagged rabbit antisera to adenovirus types 4 and 7. The method was as sensitive as the standard virus isolation procedures, but serological cross reactions were observed. Viral antigens were detected in both the nucleus and cytoplasm of infected cells. Infection was accompanied by the outpouring of large numbers of polymorphonuclear leukocytes and smaller numbers of mononuclear cells. The method provides a model for the study of the cellular response to viral upper respiratory disease. PMID- 4342844 TI - Frey's syndrome. PMID- 4342843 TI - Serum lipoprotein deficiency in diffuse "normolipemic" plane xanthoma. PMID- 4342842 TI - Concentration of reovirus and adenovirus from sewage and effluents by protamine sulfate (salmine) treatment. AB - Protamine sulfate was employed to recover reoviruses, adenoviruses, and certain enteroviruses from sewage and treated effluents; 50- to 400-fold concentration of viral content was achieved. PMID- 4342845 TI - Neurotoxicity of sulfones. PMID- 4342848 TI - Summary of the seminar on viral hepatitis. PMID- 4342846 TI - [Enzyme cytochemical studies on cell suspensions and primary cultures of guinea pig epidermis]. PMID- 4342847 TI - [The cytochemical enzyme reaction pattern of long term cell cultures from guinea pig epidermis]. PMID- 4342849 TI - [Free radicals and C13-C12 ratio in plant tumors]. PMID- 4342850 TI - [Radioimmunologic determination of AMPc and GMPc. Preparation, purification and assay of 2'0-succinyl-AMP-3'5'-cyclic and of 2'0-succinyl-GMP-3'5'-cyclic]. PMID- 4342851 TI - [Effect of taurine on electroretinography of the retina in perfusion]. PMID- 4342853 TI - Electron microscopic study of so-called "pulmonary sclerosing hemangioma". Report of a case suggesting epithelial origin. PMID- 4342854 TI - Fine structure of bronchiolo-alveolar cell carcinoma. PMID- 4342852 TI - Oat-cell carcinoma of the lung. Clinical and morphological studies in relation to its histogenesis. PMID- 4342855 TI - Infectious mononucleosis prior to acute leukemia: a possible role for the Epstein Barr virus. PMID- 4342856 TI - Mithramycin (NSC 24559) therapy of testicular tumors. PMID- 4342857 TI - Thermographic "edge sign" in breast carcinoma. PMID- 4342858 TI - Bilateral Wilms' tumor. A review. PMID- 4342859 TI - Light and electron microscopy of giant-cell glioblastoma. PMID- 4342860 TI - [The mechanism of the effect of ACTH and hydrocortisone on gastric secretion]. PMID- 4342861 TI - [Changes in plasma free fatty acids after the administration of several hormones related to the pituitary-adrenocortical and the sympathetico-medullary system]. PMID- 4342863 TI - Enzyme cytochemistry of cell cultures subjected to the action of Staphylococcus alpha-toxin. PMID- 4342864 TI - Precise cytochemical measurement of neotetrazolium formazan by scanning and integrating microdensitometry. PMID- 4342862 TI - [Cryoglobulinemia]. PMID- 4342865 TI - Effect of lymphocytosis-promoting factor of Bordetella pertussis on the immune response. I. Suppression of cellular hypersensitivity reactions. PMID- 4342866 TI - Effect of lymphocytosis-promoting factor of Bordetella pertussis on the immune response. II. Adjuvant effect for the production of reaginic antibody in the rat. PMID- 4342867 TI - Bovine parainfluenza Type 3 virus infection and pasteurellosis. PMID- 4342868 TI - Factors influencing the epidemiology and epizootiology of airborne diseases. PMID- 4342869 TI - Herpes zoster of the head and neck. PMID- 4342871 TI - An ultrastructure study of herpes simplex virus encephalitis. PMID- 4342870 TI - Factors influencing the cell type of brain tumors induced in dogs by Schmidt Ruppin Rous sarcoma virus. PMID- 4342872 TI - Synergism between polyoma and inactivated Sendai virus in human astrocytes, fibroblasts and HeLa cells. PMID- 4342873 TI - The role of cyclic AMP in the regulation of cellular processes. PMID- 4342874 TI - [Standardization of lactate determination in the blood of children and adolescents]. PMID- 4342875 TI - [Osseous effects of hyperthyroidism]. PMID- 4342876 TI - Sclerema neonatorum treated with glucagon and tetracosactrin. PMID- 4342877 TI - Electrical responses of insect central neurons: augmentation by nerve section or colchicine. AB - Intracellular recording from the somata of central motor neurons in the cockroach Periplaneta americana normally shows little or no electrical response evoked by soma depolarization or by antidromic stimulation. Within 4 days after either cutting the axon or administration of colchicine, large action potentials can regularly be recorded from cell bodies of metathoracic motor neurons. Each experimental procedure evokes formation of a dense, perinuclear ribonucleic acid ring in the soma of neurons showing augmented electrical responses. PMID- 4342878 TI - Murine leukemia virus: restriction in fused permissive and nonpermissive cells. AB - Cultures of human cells nonpermissive for mouse leukemia virus replication could not be induced to support virus replication by homologous fusion in the presence of Moloney leukemia virus. Human cells were also fused with permissive mouse cells, and the fate of the virus in heterokaryons was determined by a simultaneous autoradiography and fluorescent antibody technique. Heterokaryons containing the full chromosome complement of both cells were likewise nonpermissive for virus synthesis, but hybrids of human and mouse cells, which lacked up to half of the human chromosome complement, were permissive for virus synthesis. The results suggest that human cell genes can direct a repressive control over mouse leukemia virus replication. PMID- 4342879 TI - Physiological and chemical studies on Gymnodinium breve Davis toxin. PMID- 4342880 TI - [Dry liver resection using vital fixation of the liver segment]. PMID- 4342881 TI - Determination of inorganic phosphate in rat liver. PMID- 4342882 TI - Pseudomonas cytochrome c peroxidase. IV. Some kinetic properties of the peroxidation reaction, and enzymatic determination of the extinction coefficients of Pseudomonas cytochrome c-551 and azurin. PMID- 4342883 TI - Effect of irradiation temperature on the yield of UV-induced trapped electrons in ethyleneglycol-water glass. PMID- 4342884 TI - Tissue effects of glucocorticoids. PMID- 4342885 TI - Regulation of glucocorticoid release. PMID- 4342886 TI - Aldosterone biosynthesis. Interrelationship of regulatory factors. PMID- 4342887 TI - The regulation of aldosterone secretion in primary aldosteronism. PMID- 4342888 TI - The control of aldosterone secretion in normal and hypertensive man: abnormal renin-aldosterone patterns in low renin hypertension. PMID- 4342889 TI - Laboratory evaluation of disorders of the adrenal cortex. PMID- 4342890 TI - Pulmonary deposits of titanium dioxide in man. PMID- 4342891 TI - Cirrhosis of the liver associated with 1 -antitrypsin deficiency. PMID- 4342892 TI - Comparative studies of six avian herpesviruses. PMID- 4342893 TI - Attempted application of avian viral antibody test for detection of other microbial infections. PMID- 4342894 TI - Mucosal cells of the small bronchioles of prematurely born human infants (600 1700 g). PMID- 4342895 TI - Specificity of interaction of haptoglobin with mammalian hemoglobin. PMID- 4342896 TI - Cross-partition of proteins. Effect of ionic composition and concentration. PMID- 4342897 TI - Turnover of deoxyribonucleic acid, histones, and lysine-rich histone phosphate in hepatoma tissue culture cells. PMID- 4342899 TI - Kinetics and mechanism of the isoalloxazine (flavine) dehydrogenation of dimethyl dihydrophthalates. PMID- 4342898 TI - Molecular nature of F 1 histone phosphorylation in cultured hepatoma cells. PMID- 4342901 TI - Spectroscopic properties of N-bromosuccinimide-modified horse heart cytochrome c + . PMID- 4342902 TI - Isolation and identification of 24,25-dihydroxycholecalciferol, a metabolite of vitamin D made in the kidney. PMID- 4342900 TI - Circular dichroism studies of N-bromosuccinimide-modified horse heart cytochrome c preparations. PMID- 4342903 TI - Yeast diphosphopyridine nucleotide specific isocitrate dehydrogenase. Regulation of activity and unidirectional catalysis. PMID- 4342905 TI - Proton exchange of nucleic acids. Amino protons of mononucleotides. PMID- 4342904 TI - Polynucleotides containing 2'-chloro-2'-deoxyribose. PMID- 4342906 TI - The metabolism of benzoate and methylbenzoates via the meta-cleavage pathway by Pseudomonas arvilla mt-2. PMID- 4342907 TI - Esterase activity of chymotrypsin on oxygen-substituted tyrosine substrates. PMID- 4342909 TI - Resolution of the hemolytic and the hydrolytic activities of phospholipase-C preparation from Clostridium perfringens. PMID- 4342908 TI - The metabolic divergence in the meta cleavage of catechols by Pseudomonas putida NCIB 10015. Physiological significance and evolutionary implications. PMID- 4342910 TI - The amino-acid sequence of neurotoxin II of Androctonus australis Hector. PMID- 4342911 TI - The effect of ether anaesthesia stress on cholesterol-side-chain cleavage and cytochrome P450 in rat-adrenal mitochondria. PMID- 4342912 TI - The biosynthesis of the diterpenes. PMID- 4342913 TI - In vitro repair of single-strand breaks in -irradiated DNA by polynucleotide ligase. PMID- 4342914 TI - Radiosensitization of anoxic cells of E. coli K-12 by organic nitroxyl free radicals. PMID- 4342915 TI - Yield of x-ray-induced DNA single-strand breaks in niacin-starved E. coli K-12. PMID- 4342916 TI - Mechanisms of virus-induced cell fusion. PMID- 4342917 TI - Late results of treatment and prognosis in tumours of the renal parenchyma. PMID- 4342918 TI - Angiotensin and renal function. PMID- 4342919 TI - Enzymatic-histochemical studies in experimental uraemia. PMID- 4342922 TI - Surveillance of whooping cough in Czechoslovakia. II. Incidence of antigenic types of B. pertussis in Czechoslovakia in the years 1966-1970. PMID- 4342920 TI - Further histochemical studies on the testes of infertile men. PMID- 4342921 TI - Electrochemical studies of heme proteins. Coulometric, polarographic, and combined spectroelectrochemical methods for reduction of the heme prosthetic group in cytochrome c. PMID- 4342923 TI - Incidence of precipitins to varicella-zoster virus in different age groups. PMID- 4342924 TI - Incidence of antibodies to EB virus in infectious mononucleosis patients. PMID- 4342925 TI - Nucleoside-coated bacteriophage T4: a method for the detection and characterization of anti-nucleoside antibodies. PMID- 4342926 TI - Determination of plasma renin activity by radioimmunoassay: comparison of results from two commercial kits with bioassay. PMID- 4342927 TI - Protracted rebound in rapid movement sleep time and electroencephalogram voltage output in morphine-dependent rats upon withdrawal. PMID- 4342928 TI - Pre- and postsynaptic origin of the norepinephrine metabolites formed during transmitter release elicited by nerve stimulation. PMID- 4342929 TI - [Radioimmunoassay of angiotensin I. Its application to measurement of plasma renin activity]. PMID- 4342930 TI - [Nonfunctional langerhansian cancer with hepatic metastases. Treatment with streptozotocin]. PMID- 4342931 TI - Abnormal lipid composition of very low density lipoproteins in diagnosis of broad beta disease (type 3 hyperlipoproteinemia). PMID- 4342933 TI - Defectivity of Rauscher murine erythroblastosis virus. PMID- 4342934 TI - Contact inhibition of transformed cells incompletely restored by dibutyryl cyclic AMP. PMID- 4342932 TI - Studies of hyperlipidemia in the HGH-deficient state. PMID- 4342935 TI - [Herpetic encephalitis]. PMID- 4342936 TI - [Cytomegalic inclusion disease. Congenital form with favorable course]. PMID- 4342937 TI - Hippocampal lesions and shuttlebox avoidance behavior: a fear hypothesis. PMID- 4342938 TI - [The response of cortisol to depot synthetic ACTH stimulation]. PMID- 4342940 TI - A calcium-citro-phosphate technique for the histochemical localization of myosin ATPase. PMID- 4342939 TI - [Pituitary adenoma with lactotropic cells and adenoma with galactorrhea]. PMID- 4342942 TI - [ECG monitoring of the patient outside the hospital]. PMID- 4342941 TI - Concurrent respiratory and genital disease associated with infectious bovine rhinotracheitis-infectious pustular vulvo-vaginitis (IBR-IPV) virus in a dairy herd in the United Kingdom. PMID- 4342943 TI - Control of expression of genetic information in E. coli by cyclic AMP. PMID- 4342944 TI - Role of brain norepinephrine and serotonin in the tonic and phasic regulation of hypothalamic hypophyseal adrenal axis. PMID- 4342945 TI - Psychoactive drugs and brain neurochemical transmitters. PMID- 4342947 TI - Biochemical changes in Bifidobacterium bifidum var. pennsylvanicus after cell wall inhibition. V. Structure of the galactosyldiglycerides. PMID- 4342948 TI - Cyclic AMP synthesis in rabbit graafian follicles and the effect of luteinizing hormone. PMID- 4342946 TI - Pharmacological aspects of peripheral noradrenergic transmission. PMID- 4342949 TI - Angiotensin increases microsomal (Na + -K + )-ATPase activity in several tissues. PMID- 4342950 TI - Drug reactions. XIX. Adverse cutaneous reactions to the penicillins--ampicillin rashes. PMID- 4342951 TI - Inhibition of methaemoglobin reduction by sodium salicylate. PMID- 4342952 TI - [Possible epidemiologic consequences in Africa from the discovery of Australia antigen]. PMID- 4342954 TI - [Ganglioneuroma and insulinoma of the pancreas. Incidental or induced combined occurrence?]. PMID- 4342953 TI - The processing of polyoma virus RNA synthesized during productive infection in mouse cells. PMID- 4342955 TI - Stimulatory effects of induced phagocytosis on the function of isolated thyroid cells. AB - Stimulation of endocytosis is a very early effect of thyrotropin on thyroid. However, the relationship of the endocytotic process to the many other thyrotropin effects on thyroid is not clearly defined. Since phagocytosis in isolated thyroid cells is a presumed model for in vivo endocytosis of colloid, we induced phagocytosis in isolated thyroid cells by incubating them at 37 degrees C with 0.109-mu diameter polystyrene microbeads; phagocytosis was confirmed in each experiment by electron microscopy and/or spectrophotometric analysis of dioxane cell extracts. Cells incubated with 50-100-mu diameter polystyrene macrobeads (too large to ingest) served as controls. Microbead-induced phagocytosis in isolated thyroid cells was consistently accompanied by increases in: (a) cyclic 3',5'-adenosine monophosphate-(14)C formation from adenine-8-(14)C (66%); (b) iodide-(131)I trapping (40%); (c) protein and RNA synthesis (30%); (d) phospholipogenesis (50%); (e) alpha-aminoisobutyric acid-1-(14)C uptake (15%). 50 to 100-mu diameter polystyrene macrobeads did not influence cell function in any of these experiments. Aminotriazole, 5 x 10(-3) (M), a peroxidase inhibitor, blocked the stimulatory effect of microbead-induced phagocytosis on phospholipogenesis only. These studies indicate that in isolated thyroid cells the phagocytotic process, per se, may alter activity of the membrane-bound adenyl cyclase enzyme. The resultant increase in cyclic 3',5'-adenosine monophosphate may be a triggering mechanism for (some) subsequent metabolic changes occuring during phagocytosis. Since these changes mimic those induced by thyrotropin, it is suggested that a variety of thyrotropin effects on thyroid may be secondary to stimulation of colloid resorption and hormone secretion. PMID- 4342956 TI - Uterine blood flow and uterine renin secretion. AB - Experiments were carried out in pregnant nephrectomized rabbits to determine the relationship between uterine blood flow and uterine renin secretion. Uterine blood flow was measured by the percentage distribution of radioactive microspheres injected into the left ventricle which lodged in uterus and placenta, and cardiac output was measured by dye dilution. In 40 animals, 24 hr after nephrectomy, uterine blood flow was 4.7+/-0.4% of cardiac output and absolute flow 32.4+/-3 ml/100 g per min. Plasma renin activity (PRA) in uterine vein, 994+/-182 ng/100 ml per hr, was higher than in carotid artery, 832+/-143 (P < 0.025). With reduction of uterine blood flow from 4.7+/-0.5 to 1.95+/-0.3% of cardiac output and absolute flow from 30.8+/-4.6 to 8.8+/-2 ml/100 g per min, uterine vein PRA rose from 1434+/-234 to 4430+/-300 (P < 0.001), and carotid artery PRA from 1009+/-200 to 2300+/-350 (P < 0.01). Hemorrhagic hypotension caused uterine vein PRA to increase from 913+/-293 to 3638+/-1276 (P < 0.001) and carotid artery PRA from 774+/-252 to 1730+/-433 (P < 0.01). Uterine blood flow expressed as a percentage of cardiac output remained constant after hemorrhage, 5.5+/-0.9 and 6.3+/-0.8%, although absolute flow fell from 37+/-7.7 to 29+/-3.6 ml/100 g per min because of the large fall in cardiac output which occurred.Angiotensin, 10 ng/kg per min, caused no significant change in blood pressure or cardiac output but increased uterine blood flow from 4.1+/-0.6 to 8.4+/-1% (P < 0.005) of cardiac output with absolute flow increasing from 37.4+/ 7 to 73.2+/-10 ml/100 g per min (P < 0.001). The increase in uterine blood flow during angiotensin was abolished by the prior administration of propranolol. Isoproterenol, 0.5 mu/min, increased uterine blood flow from 3.5+/-0.6 to 6.4+/ 1.2% of cardiac output (P < 0.02) with absolute flow increasing from 25+/-5 to 51+/-12 ml/100 g per min (P < 0.05). Norepinephrine, 500 ng/min, caused no significant change in uterine blood flow. These findings suggest that uterine renin might be involved in regulating uterine blood flow, secretion being increased in response to a reduction in flow with the resultant rise in circulating or local angiotensin, through beta adrenergic stimulation, increasing uterine blood flow. PMID- 4342957 TI - Metabolism of 1,25-dihydroxycholecalciferol in the rat. AB - Administration of 60 pmoles of 1,25-dihydroxycholecalciferol to vitamin D deficient rats on a low calcium diet gives a maximal intestinal calcium transport response in 7 hr and a maximal bone calcium mobilization response in 12 hr. During the 48 hr after injection of radioactive 1,25-dihydroxycholecalciferol, unchanged 1,25-dihydroxycholecalciferol accounts for 71-98% of the radioactivity found in the intestine with minor amounts appearing in more polar metabolites. In the bone, for the 1st 12 hr, 1,25-dihydroxycholecalciferol is the major form (75 82%) present while at 24 hr, the amount of 1,25-dihydroxycholecalciferol decreases with a corresponding rise in the amounts of metabolites both less polar and more polar than the 1,25-dihydroxycholecalciferol. Since these metabolies are at their highest concentration when bone calcium mobilization is decreasing, they are most likely not responsible for the calcium mobilization observed during the 1st 12 hr. The appearance of water-soluble radioactivity in the kidney, plasma, liver, and muscle 24 hr after 1,25-dihydroxycholecalciferol injection has been demonstrated. The present results suggest that, although 1,25 dihydroxycholecalciferol is converted to further metabolites in the rat, it is probably the form of vitamin D responsible for initiating intestinal calcium transport and bone calcium mobilization. PMID- 4342959 TI - Molecular symmetry of human glyceraldehyde 3-phosphate ddehydrogenase and its transformation during coenzyme binding. PMID- 4342958 TI - A collagenolytic system produced by primary cultures of rheumatoid nodule tissue. AB - A collagenase and a neutral protease have been insolated and characterized from primary cultures obtained from rheumatoid subcutaneous nodules. Release of both active enzymes was maximal between the 3rd and 7th days of culture and was stimulated by the presence of small amounts of colchicine (0.1 mug/ml) added to the culture medium. Both the protease and the collagenase from nodule tissue were active at physiologic pH and were inhibited by chelating agents, sulfhydryl compounds, and 1:40 dilutions of human serum. Both enzymes appeared to have a molcular size equivalent to similar enzymes found in cultures of rheumatoid synovium. The nodule collagenase was purified by chromatography on molecular sieve columns followed by affinity chromatography. The pure enzyme cleaved collagen in solution at 24 degrees C at the locus common for mammalian collagenases to act: three quarters of the distance from the amino-terminus. Under the same conditions the purified enzyme cleaved gelatin (denatured collagen) at the same locus. It is likely therefore that the collagenase in rheumatoid connective tissues functions to produce the initial cleavage of collagen and that after the initial reaction products are denatured, proteases digest them into smaller polypeptides more rapidly than does the collagenase itself. Since rheumatoid nodules grow centrifugally at the expense of the palisading fibroblast layer it seems possible that the central necrotic areas are caused by release of collagenase and protease from the highly cellular palisading zone resulting in the destruction of the extracellular collagen matrix. PMID- 4342961 TI - [Preventive vaccination of dogs against infectious hepatitis. I. Attempts to extract and test an inactivated vaccine]. PMID- 4342960 TI - [A case of congenital epulis]. PMID- 4342962 TI - The central nervous system and Cushing's syndrome. PMID- 4342963 TI - E.N.T. case of the month. PMID- 4342964 TI - Electron paramagnetic resonance of single crystal oxycobaltmyoglobin and deoxycobaltmyoglobin. AB - Single crystals of oxycobaltmyoglobin and deoxycobaltmyoglobin have been prepared and found to be isomorphous. The paramagnetic resonance spectra of deoxycobaltmyoglobin yield g(xx) = 2.33(0), g(yy) = 2.32(3), g(zz) = 2.02(8) with the z-axis parallel to the "heme" normal. The A(Co) and g tensors share the same principal axes with|A(Co) parallel| = 79 G and|A(Co)[unk]| = 6 G. A value of A(N) = 17.5 G was also obtained for the epsilon-N atom of the F8 histidine. There are two paramagnetic species in oxycobaltmyoglobin having apparently identical g tensors (gxixi = 2.08(3), getaeta = 2.00(6), and gzetazeta = 1.98(9)) but different A(Co)-tensors. Furthermore, g values A(Co) do not share the same principal axes. The A(Co)-values for one of the species are (A(xx) = 16.7 G, A(yy) = 5.95 G, A(zz) = 9.3 G), they are all 40% larger for the other species. The two species are oriented 90 degrees to each other in the crystal. The results from electron paramagnetic resonance studies are consistent with a pi-bounded structure for (Co)MbO(2). PMID- 4342966 TI - Biochemically differentiated neoplastic clone of Schwann cells. AB - Four clonal lines have been established in tissue culture from a transplantable tumor of cervical nerve-root induced transplacentally with ethylnitrosourea in an inbred BD-IX rat strain. One clone (RN-2) has several biochemical properties of the nervous system that led to its classification as a Schwann cell line, namely (a) the synthesis of the nervous system specific protein S-100, (b) a high specific activity of 2',3'-cyclic nucleotide-3'-phosphohydrolase, an enzyme present in high specific activity only in glial cells, and (c) the presence of a basic protein related by immunological crossreaction, molecular size, and amino acid composition to the encephalitogenic protein from beef brain myelin. Clone RN 2 has a high plating efficiency, a doubling time of about 20 hr, and a mean of 43 chromosomes of normal morphology. Clone RN-2 has also been inoculated subcutaneously into syngeneic rats and grown as a clonal tumor with good growth properties. PMID- 4342965 TI - DNA-dependent DNA polymerases I and II from normal human-blood lymphocytes. AB - Two DNA polymerases have been purified from blood lymphocytes of normal human individuals. In contrast to a DNA polymerase isolated from lymphoblasts from individuals with leukemia, neither of the DNA polymerases from normal lymphocytes transcribes the heteropolymeric regions of tumor-virus RNA into DNA. PMID- 4342967 TI - Lysyl-protocollagen hydroxylase deficiency in fibroblasts from siblings with hydroxylysine-deficient collagen. AB - Cell culture studies were performed on members of a family in which two sisters, ages 9 and 12, have a similar disorder characterized clinically by severe scoliosis, joint laxity and recurrent dislocations, hyperextensible skin, and thin scars. The skin collagen from the sisters was markedly deficient in hydroxylysine, but other amino acids were present in normal amounts. Hydroxylysine in collagen from fascia and bone was reduced to a lesser extent. Since the most likely explanation for the hydroxylysine deficiency was a reduction in enzymatic hydroxylation of lysine residues in protocollagen, we measured the activity of lysyl-protocollagen hydroxylase in crude lysates of cultured skin fibroblasts. Enzyme activities in the two affected children were 14 and 10% of controls, whereas the activity was about 60% of normal in the mother, a pattern most consistent with autosomal recessive inheritance. The mutant enzyme demonstrated the same cofactor requirements as that from normal cells. Deficiency of lysyl-protocollagen hydroxylase is the first inborn error of human collagen metabolism to be defined at the biochemical level. PMID- 4342968 TI - Biochemical method for inserting new genetic information into DNA of Simian Virus 40: circular SV40 DNA molecules containing lambda phage genes and the galactose operon of Escherichia coli. AB - We have developed methods for covalently joining duplex DNA molecules to one another and have used these techniques to construct circular dimers of SV40 DNA and to insert a DNA segment containing lambda phage genes and the galactose operon of E. coli into SV40 DNA. The method involves: (a) converting circular SV40 DNA to a linear form, (b) adding single-stranded homodeoxypolymeric extensions of defined composition and length to the 3' ends of one of the DNA strands with the enzyme terminal deoxynucleotidyl transferase (c) adding complementary homodeoxypolymeric extensions to the other DNA strand, (d) annealing the two DNA molecules to form a circular duplex structure, and (e) filling the gaps and sealing nicks in this structure with E. coli DNA polymerase and DNA ligase to form a covalently closed-circular DNA molecule. PMID- 4342969 TI - Assembly of tobacco mosaic virus in vitro: effect of state of polymerization of the protein component. AB - We previously proposed that the assembly of tobacco mosaic virus is initiated by disks of 34 protein subunits attaching to the RNA, after which the particle grows by the addition of further disks. Other workers have reported growth from "A protein" instead. We now report experiments that confirm our previous results and show that the contrary findings are largely due to a nonequilibrium form of A protein that has a "memory" for the disk state and rapidly reaggregates, either in solution or on the growing particle. PMID- 4342970 TI - Karyotypic, virologic, and immunologic analyses of two continuous lymphocyte lines established from New Zealand black mice: possible relationship of chromosomal mosaicism to autoimmunity. AB - Two continuous-suspension lymphocyte lines were isolated from the spleen and fibrosarcoma of a New Zealand Black female mouse. A C-type virus with a density of 1.16 g x cm(-3), 70S RNA, and RNA-directed DNA polymerase activity was isolated. The virus was infectious for NRK, NZB, (NZB x NZW)F(1), and (NZW x NZW)F(1) embryos, and for BALB/c 3T3 cells, but not for NIH Swiss cells. All cells from established lymphocyte cultures, as well as some embryo cells from New Zealand Black mice, showed karyotypic abnormalities. The possibility of chromosomal mosaicism is suggested. PMID- 4342972 TI - Purification and properties of bacteriophage T4-induced RNA ligase. AB - An enzyme, purified 300-fold from Escherichia coli infected with bacteriophage T4, catalyzes the conversion of 5'-termini of polyribonucleotides to internal phosphodiester bonds. The reaction requires ATP and Mg(++). For every 5'-(32)P terminus rendered resistant to alkaline phosphatase, an equal amount of AMP and PPi are formed. Various polyribonucleotides are substrates in the reaction; to date, the best substrate is [5'-(32)P]polyriboadenylate. With the latter substrate, no evidence of intermolecular reaction was obtained. However, the 5' (32)P termini of poly(A) rendered resistant to alkaline phosphatase are also resistant to attack by RNase II, polynucleotide phosphorylase, and low concentrations of venom phosphodiesterase. Since the product formed with poly(A) lacks 3'-hydroxyl ends, as measured with these exonucleases, the enzyme appears to convert linear molecules of polyriboadenylate to a circular form by the intramolecular covalent linkage of the 5'-phosphate end to the 3'-hydroxyl terminus. PMID- 4342971 TI - Alteration of the cytotoxic action of sensitized lymphocytes by cholinergic agents and activators of adenylate cyclase. AB - The cytotoxic action of lymphocytes upon cells bearing alloantigens to which they are sensitized is inhibited by agents that elevate intracellular amounts of 3':5' cyclic AMP: prostaglandin E(1), cholera toxin, and theophylline. Cholinergic agents, added in the range of 1 to 100 pM, enhance cytotoxicity, an effect that is blocked by atropine. Because cholinergic agents elevate cyclic GMP in other in vitro systems, these findings suggest that the cytotoxic process effected by sensitized lymphocytes is a secretory phenomenon modulated by cyclic AMP and cyclic GMP. PMID- 4342973 TI - Guanosine 3':5'-cyclic monophosphate: a possible intracellular mediator of mitogenic influences in lymphocytes. AB - Adenosine 3':5'-cyclic monophosphate (cyclic AMP) has been shown to have an antimitotic role in various cell types, and it has been hypothesized that a decrease of cyclic AMP concentration in the cell initiates or permits cell division. This hypothesis has been evaluated with respect to clonal proliferation of lymphocytes. Two potent mitogenic agents, phytohemagglutinin and concanavalin A, which induce thymic-dependent lymphocytes to undergo clonal proliferation, were examined for their ability to initiate proliferation and to alter the concentrations of cyclic AMP and guanosine 3':5'-cyclic monophosphate (cyclic GMP) in purified human peripheral blood-lymphocytes. Optimal mitogenic concentrations of phytohemagglutinin and concanavalin A produced 10- to 50-fold increases in the concentration of lymphocyte cyclic GMP within the first 20 min of exposure to the mitogens. No changes were seen in the concentration of cyclic AMP after stimulation with either mitogen in purified form. Increases of less than 2-fold in the concentration of lymphocyte cyclic AMP observed with a less purified preparation of phytohemagglutinin could be attributed to the agglutinating rather than the mitogenic properties of the mitogen. A revised hypothesis is presented in which a temporally discrete rise in lymphocyte cyclic GMP concentration is viewed as an active signal to induce proliferation, while the elevation of cyclic AMP concentration in these cells is viewed as a regulatory influence that limits or inhibits mitogenic action. PMID- 4342974 TI - Structural and functional characterization of isolated pancreatic exocrine cells. AB - Viable isolated exocrine cells have been obtained from guinea-pig pancreas by a tissue dissociation procedure using crude collagenase (EC 3.4.4.19) and hyaluronidase (EC 3.2.1.35), chelation of divalent cations, and mild shearing forces. Cell yields are 50-60%, based on recovered DNA, and about 90% of the population consists of exocrine cells which, although rounded up, retain their in situ polarity with regard to regional distribution of zymogen granules and specialization of the former luminal plasmalemma. The isolated cells incorporate labeled amino acids into proteins at linear rates for at least 4 hr at levels comparable to pancreatic slices in vitro; more than 95% of the exocrine cell population is active in this process, as shown by autoradiography. In response to secretogogues at optimal doses (100 muM carbamylcholine; 0.1 muM pancreozymin, or 0.01 muM caerulein), the cells discharge up to 30% of their content of pulse labeled secretory proteins to the medium over a 3-hr period; in the same time, the controls release about 5% of their content. The results indicate that isolated exocrine cells are capable of synthesizing the processing secretory proteins, and of responding directly to cholinergic and peptidic secretogogues. PMID- 4342975 TI - Evidence for coadaptation in Avena barbata. AB - Two populations of Avena barbata have been sampled intensively and allelic frequencies have been determined on a fine grid for six enzyme loci. The distribution of alleles among microniches within the location occupied by one of these populations (CSA-1) was correlated with environment following patterns of macro- and microdifferentiation previously described in California. Multilocus analyses revealed striking gameticphase disequilibrium for both linked and unlinked loci, and also that two balanced five-locus gametic types, one associated with mesic conditions and the other with more xeric conditions, are in substantial excess at the CSA-1 location. Evidence is presented that these two gametic types are maintained by selection acting on two coadapted combinations of alleles, held together by restriction of recombination resulting from linkage and/or inbreeding. Gametic-phase disequilibrium featuring different allelic complexes were found in each of three microniches in the second population (Geyserville), which occupies a site that is environmentally atypical for A. barbata. PMID- 4342977 TI - [Cultural influences on the body image in the African environment]. PMID- 4342976 TI - [Clinical and epidemiological aspects of an outbreak of acute respiratory tract diseases in a closed community of infants]. PMID- 4342978 TI - Studies on the accumulation mechanisms of 67 Ga in tumors: role of calcium metabolism. PMID- 4342980 TI - The virus plaque assay and the effector cell in cell-mediated immune reactions. PMID- 4342979 TI - Wilms' tumor in three successive generations. PMID- 4342981 TI - Influence of cortisol on brain and spinal excitability in developing rats. PMID- 4342982 TI - Local effects of adrenal steroids on cerebral neurons. PMID- 4342983 TI - Selectivity of acute feedback effects of corticosteroids on ACTH secretion. PMID- 4342984 TI - Pituitary-adrenocortical activity, exploration and avoidance behavior in the rat. PMID- 4342985 TI - Modification of the responsiveness of components of the limbic-midbrain circuit by corticosteroids and ACTH. PMID- 4342986 TI - Herpes virus hominis type 2 and intranuclear tubular structures in organized nervous tissue cultures. PMID- 4342987 TI - Relation between cellular immunity to nephroblastoma and the phase of the disease. PMID- 4342988 TI - [The diagnosis and antenatal prevention of hemolytic disease of the newborn in Rh sensitized women]. PMID- 4342989 TI - Dust conditions in brick plants of Ontario. PMID- 4342990 TI - Ultrastructural studies of the effects of various agents on the motor neurons of the spinal cord. PMID- 4342991 TI - Effects of viral infection on nervous system development. II. Attempts to modify bluetongue-virus-induced malformations with cyclophosphamide and antithymocyte serum. AB - Treatment with cyclophosphamide and antithymocyte serum (ATS) did not significantly increase the susceptibility of mice to bluetongue virus infections of the nervous system. Cyclophosphamide actually inhibited virus growth in newborn and 2-week-old mice and, in newborn mice, diminished the severity of virus-induced pathologic sequelae. Autoradiographic studies suggested this inhibition resulted from the effect of cyclophosphamide on the immature cells of the subventricular zone which were the cell population selectively infected by bluetongue virus. In newborn mice ATS inhibited the inflammatory reaction and development of antibody, but did not result in alterations in mortality, initial virus growth and localization or early necrosis of cells in the subventricular zone. Antithymocyte serum only caused longer persistence of virus and slight extension of late pathologic lesions. The failure of cyclophosphamide and ATS treatment to induce more extensive lesions in older mice show that the age dependency of bluetongue lesions is not determined by the immaturity of immune responses. PMID- 4342992 TI - Mouse cytomegalovirus. Necrosis of infected and morphologically normal submaxillary gland acinar cells during termination of chronic infection. AB - The ultrastructural lesions in the submaxillary glands of C(3)H mice chronically infected with the murine cytomegalovirus are reported. Virus was synthesized in the nucleus of acinar glandular cells. After passage into the cytoplasm, virus was located in large vesicles which were derived from the Golgi apparatus. These vesicles, which were periodic acid-Schiff positive, migrated to the apex of the cell and released virus into the acinar lumen or canaliculi. Eventually, lymphocytes infiltrated the interstitium and surrounded the basal lamina of acini which contained infected cells. In acini encompassed by lymphocytes, both infected cells and morphologically normal acinar cells simultaneously degenerated, producing a small focus of necrosis. Physical contact between lymphocytes and necrotic cells did not occur for an intact basal lamina was always found interposed between them. Degeneration of infected cells coincided with a decrease in virus titer in the salivary glands. Degeneration of infected and normal acinar cells also occurred in DBA 2 mice which lack the fifth component of complement. In mice conditioned with cortisone to suppress inflammation, neither infected nor normal acinar cells degenerated. We concluded from the electron microscope observations that lymphocytes terminate chronic MCMV infection, that MCMV infection of acinar epithelium is not cytolytic and that normal cells also undergo necrosis during termination of chronic MCMV infection. It is postulated that lymphocytes in responding to infection release a cytotoxic substance which diffuses into the acini and causes indiscriminate necrosis of acinar cells. PMID- 4342993 TI - Effects of viral infection on nervous system development. I. Pathogenesis of bluetongue virus infection in mice. AB - Bluetongue vaccine virus was adapted to mice by serial intracerebral passage. The adapted virus was found to multiply selectively in immature cells of the subventricular zone of the forebrain and spread along cell migratory pathways to the olfactory bulbs, caudate/putamen, hippocampus and areas of cerebral cortex. Symmetrical, mineralized, partially cavitated lesions developed in these areas as a sequela of the infection. Infection of fetal mice led to more severe cerebral malformation, and infection of 2-week-old mice resulted in very limited multiplication without sequelae. The pattern of infection correlated with the maturation and migration of cells within the developing telencephalon. PMID- 4342994 TI - A sensitive and specific plate test for the quantitation of phospholipases. PMID- 4342995 TI - Fluorometric determination of pyridoxal phosphate in microgram samples of tissue. PMID- 4342996 TI - A protein precipitant useful in pteridine and purine analysis. PMID- 4342997 TI - Polarographic assay of p-nitrophenyl phosphatase activity. PMID- 4342998 TI - Extraction, purification, and estimation of ATP from leaves, floral buds, and immature fruits of cotton. PMID- 4342999 TI - [Comparative histochemical determinations of glycogen]. PMID- 4343000 TI - [Technical problems in the radioimmunologic determination of angiotensin II]. PMID- 4343001 TI - [Influence of the lipid load on the curve of Lipiodol load]. PMID- 4343002 TI - Rhinoviruses. PMID- 4343003 TI - Glycolysis, respiration, and anomalous gene expression in experimental hepatomas: G.H.A. Clowes memorial lecture. PMID- 4343004 TI - Enhancement of urinary bladder tumorigenesis in hamsters by coadministration of 2 acetylaminofluorene and indole. PMID- 4343006 TI - The synergistic effect of hypoglycemia and L-asparaginase upon transplantable hepatomas of varying growth rates. PMID- 4343005 TI - Studies of reticulum cell sarcoma in hamsters. PMID- 4343008 TI - Endocrine control of cyclic adenosine 3',5'-monophosphate levels in several Morris hepatomas. PMID- 4343007 TI - Influence of dietary phenylalanine deficiency on the mammary tumor virus activity in C3H mice. PMID- 4343009 TI - Suppression of SV40 T antigen in transformed hamster cells by chronic treatment with 5-bromo-2-deoxyuridine. PMID- 4343010 TI - Effect of hepatoma growth on the utilization of liver glycogen in rats. PMID- 4343011 TI - Cell loss and proliferation induced by N-2-fluorenylacetamide in the rat liver in relation to hepatoma induction. PMID- 4343012 TI - Intracranial fibroblastic neoplasms in the hamster from bovine papilloma virus. PMID- 4343014 TI - Carcinogenicity of organic fractions of particulate pollutants collected in New York City and administered subcutaneously to infant mice. PMID- 4343013 TI - Systemic promoting action of phorbol in liver and lung carcinogenesis in AKR mice. PMID- 4343015 TI - Intercellular junctions between Novikoff hepatoma cells and hepatic cells. PMID- 4343016 TI - Studies on the mechanism of action of calciferol. V. Turnover time of chick intestinal epithelial cells in relation to the intestinal action of vitamin D. PMID- 4343017 TI - [Electron microscope study of glial and fibroblast hybrid cells]. PMID- 4343018 TI - Adaptation in Lesch-Nyhan cells exposed to aminopterin. PMID- 4343019 TI - Synthesis of viral components in hybrids of differentially permissive cells infected with adenovirus type 12. PMID- 4343020 TI - Preparation of rat liver cells. I. Effect of Ca 2+ on enzymatic dispersion of isolated, perfused liver. PMID- 4343021 TI - Binucleation in mammalian liver. Studies on the control of cytokinesis in vivo. PMID- 4343022 TI - Serum requirements for survival of 3T3 and SV3T3 fibroblasts. PMID- 4343023 TI - Catechol-o-methyl-transferase activity in dibutyryl cyclic AMP, prostaglandin and x-ray -induced differentiated neuroblastoma cell culture. PMID- 4343024 TI - UV-induced DNA synthesis in Xeroderma pigmentosum nuclei in heterokaryons. PMID- 4343025 TI - [The effect of ACTH on the bioelectric activity of the rabbit brain during photo and phnostimulation]. PMID- 4343026 TI - [The effect of tubocurarine on the synaptic transmission in the cat ciliary ganglion]. PMID- 4343027 TI - Examination of the focus of variola virus-infected hela cells by scanning electron microscopy. PMID- 4343028 TI - Occupational support as a therapeutic tool. PMID- 4343029 TI - Management of patients with vaginal infections. An invitational symposium. PMID- 4343030 TI - [Current treatment and new hopes for various childhood tumors]. PMID- 4343031 TI - [Facial nerve lesions in otorhinolaryngological practice. 1. Problem diagnosis "Bell's palsy"]. PMID- 4343032 TI - [3',5'-Adenosine monophosphate in the byssus retractor muscle of the mussel Mytilus edulis]. PMID- 4343033 TI - Susceptibility of inbred Fischer rats to brain tumor induction by Rous sarcoma virus. PMID- 4343034 TI - Photosensitization by phenylalanine of carboxylic acids, amides, and peptides in frozen aqueous solution. PMID- 4343035 TI - [The role of respiratory syncytial virus in bronchopulmonary pathology in adults]. PMID- 4343036 TI - [Use of a technic of "averaging" in the study of epileptic EEG potentials in man]. PMID- 4343037 TI - [Arterial hypertension in the elderly. Search for an etiology. Anatomo-clinical correlations. Consequences and associated lesions]. PMID- 4343038 TI - [Glucose regulation in the elderly]. PMID- 4343039 TI - [Changes in plasma nonesterified fatty acids and glycerol during an induced hyperglycemia test by intravenous route in alcoholic and hemochromatotic cirrhosis]. PMID- 4343040 TI - [Harmless murmurs]. PMID- 4343041 TI - [Surgical sterilization of women]. PMID- 4343042 TI - [Lipomas of the colon]. PMID- 4343043 TI - [Disinfection of manure in large stockbreeding complexes]. PMID- 4343044 TI - [Sensitivity of geese to duck hepatitis virus]. PMID- 4343045 TI - The ultrastructure of rat lung changes induced by an anorectic drug (chlorphentermine). PMID- 4343046 TI - [Impedance findings in central hearing disorders]. PMID- 4343047 TI - [Intestinal hydrolysis of inositphosphoric acid ester and absorption of phytinphosphorus in the swine. 1. Problem definition in studies and analytical technic]. PMID- 4343048 TI - Effect of two consecutive acute stimuli on plasma aldosterone. PMID- 4343049 TI - Electron microscopic studies of replicating SV 40 DNA. PMID- 4343051 TI - Enzymic determination of L-lysine in biological materials. PMID- 4343050 TI - The lipoprotein pattern in a Danish family. Children and adolescents. PMID- 4343053 TI - Rat liver membrane preparations. PMID- 4343052 TI - A compilation of amino acid analyses of proteins. II. PMID- 4343054 TI - Analysis of myelin-synaptosomal interactions in sucrose and Ficoll-sucrose gradients. PMID- 4343055 TI - Separation of ribosomal and messenger ribonucleic acid of HeLa cells by methyl albumin kieselguhr chromatography. PMID- 4343056 TI - A new enzymic method for inorganic phosphate determination. PMID- 4343057 TI - Studies on enzyme activity on the cornea. PMID- 4343058 TI - Halogenated compounds for the sensitive detection of clostridia by gas chromatography. PMID- 4343060 TI - Molcular species of interferon induced in mice by poly I:C and Mengo virus. PMID- 4343059 TI - Some qualitative and quantitative aspects of the intestinal microflora of the glaucous-winged gull (Larus glaucescens). PMID- 4343061 TI - Induced hypertension in the treatment of severe ischemia of the foot. PMID- 4343062 TI - [Ectopic adrenocorticotropic hormone(ACTH) syndrome with polyurea]. PMID- 4343064 TI - Salivary gland diseases. PMID- 4343063 TI - [Changes of the enzyme pattern in primary tissue cultures]. PMID- 4343065 TI - Comparative histological investigation of the sequelae of experimental myelography using sodium methiodal and meglumine iothalamate. PMID- 4343066 TI - Focal encephalitis simulating neoplasm. PMID- 4343067 TI - Treatment of acute leukemia. PMID- 4343068 TI - Management of malignant solid tumors in children. PMID- 4343069 TI - Infectious mononucleosis. PMID- 4343071 TI - [The role of enteroviruses in the development of gastrointestinal disorders in young children]. PMID- 4343070 TI - The renin-angiotensin system in foetal lambs. PMID- 4343073 TI - [Clinical and histological findings in 220 cases of parotid gland tumor]. PMID- 4343072 TI - [Electron microscopy studies on the developmental stages of Eimeria maxima (Sporozoa, Coccidia). I. Ultrastructure of macrogametes]. PMID- 4343074 TI - Chlorpromazine inhibition of p-aminophenol glucuronidation by rat hepatoma cells in culture. PMID- 4343075 TI - Effects of arsenicals on viral infections in mice. PMID- 4343076 TI - Epizootiologic study of parainfluenza-3 viral infection in calves in two Alabama herds. PMID- 4343077 TI - Urinary antidiuretic hormone in polyuric disorders and in inappropriate ADH syndrome. PMID- 4343078 TI - Transmission of infectious mononucleosis by transfusion of pre-illness plasma. PMID- 4343079 TI - Hyperimmune serum against Myxovirus Parainfluenza-3 and bovine adenovirus in prophylaxis of respiratory diseases in calves. PMID- 4343080 TI - Infectious bovine rhinotracheitis (IBR): serum antibodies in cattle in Saskatchewan. PMID- 4343081 TI - Influence of spironolactone and dexamethasone on phosphoprotein phosphatase in the rat liver, kidney and spleen. PMID- 4343083 TI - Intermediates in the reaction catalyzed by glutamate dehydrogenase. PMID- 4343082 TI - Biological activity of Escherichia coli tRNA Phe modified in its C-C-A terminus. PMID- 4343085 TI - Tetrahydrobiopterin, a cofactor in mitochondrial electron transfer. Effect of tetrahydropterins on intact rat-liver mitochondria. PMID- 4343084 TI - Protein kinase from rainbow-trout-testis ribosomes. Partial purification and characterization. PMID- 4343086 TI - The "free" lipids of two different strains of hydrogen-oxidizing bacteria in relation to their growth phases. PMID- 4343087 TI - The conversion of (4- 3 H)fructose and of (4- 3 H)glucose to liver glycogen in the mouse. An investigation of the glyceraldehyde crossroads. PMID- 4343088 TI - Effects of antibiotics on the development and stability of mitochondrial enzymes in Saccharomyces cerevisiae. PMID- 4343089 TI - Spectropolarimetric studies of binary and ternary complexes of octopine dehydrogenase. PMID- 4343090 TI - The binding of steroid hormones to degranulated microsomes from rat-liver endoplasmic reticulum. PMID- 4343091 TI - Structural studies on the lipopolysaccharide of a rough strain of Escherichia coli. PMID- 4343092 TI - Glucose repression of inducible enzyme synthesis in the yeast Rhodotorula gracilis. Effect of the cell-membrane transport. PMID- 4343093 TI - Deoxyribonucleoside triphosphate pools of normal and transformed baby-hamster kidney cells. PMID- 4343094 TI - [The effect of ACTH and hydrocortisone on the gastric secretion]. PMID- 4343095 TI - Electron spin resonance study on the free radical production from N-methyl-N' nitro-N-nitrosoguanidine. PMID- 4343097 TI - Burkitt's lymphoma, nasopharyngeal carcinoma, infectious mononucleosis and the Epstein-Barr virus. PMID- 4343096 TI - [Epstein-Barr-virus-antibodies and lymphocytotoxic serum-antibodies in patients with sarcoidosis]. PMID- 4343098 TI - A physician's guide to hyperlipidemia. PMID- 4343099 TI - The cardiovascular effects of oral contraceptives. PMID- 4343100 TI - Kinetic equations for ATP--pyrophosphate exchange catalyzed by aminoacyl-tRNA synthetase. PMID- 4343101 TI - Enzymatic synthesis of certain dinucleoside monophosphates and their cleavage by snake venom phosphodiesterase. PMID- 4343102 TI - The role of inhibitory pathways in petit mal epilepsy. PMID- 4343103 TI - Lymphocyte inclusions in late-onset amaurotic idiocy. Value as a diagnostic test and genetic marker. PMID- 4343105 TI - [Paradoxical effect of parathyroid hormone. Or how it may induce hypocalcemia before hypercalcemia]. PMID- 4343104 TI - Swallow syncope. Report of a case and review of the literature. PMID- 4343106 TI - [Hereditary amyloidosis]. PMID- 4343107 TI - Biologically important isotope hybrid compounds in NMR: 1 H fourier transform NMR at unnatural abundance. PMID- 4343108 TI - Variability of vesicular stomatitis virus autointerference with different host cells and virus serotypes. PMID- 4343109 TI - Absence of transcriptase activity or transcription-inhibiting ability in defective interfering particles of vesicular stomatitis virus. PMID- 4343110 TI - Cytolytic microassays and studies of SV40 tumor-specific transplantation antigen. PMID- 4343111 TI - Protein synthesis in BHK21 cells infected with vesicular stomatitis virus. II. ts Mutants of the New Jersey serotype. PMID- 4343112 TI - Surface glycopeptides in the envelope of herpes simplex virions. PMID- 4343113 TI - Protein kinase in enveloped herpes simplex virions. PMID- 4343114 TI - A rapid direct radioimmunoassay for type C virus group-specific antigen and antibody. PMID- 4343115 TI - Syncytial cytopathic effect in KB cells of a C-type RNA virus isolated from human rhabdomyosarcoma. PMID- 4343116 TI - Selective shutoff of catabolite-sensitive host syntheses by bacroxyurea pharmaco mutation genes coliphages growth l virus replication escherichia coli growth l lysogeny crosses genetic coliteriophage N4. PMID- 4343117 TI - [Morphological studies on the ovary of Viviparus contectus (Millet 1813), (Gastropoda, Prosobranchia). I. The follicle cells]. PMID- 4343118 TI - [Electron microscopic studies on renal tubules (Malpighian tubules) in Drosophila melanogaster. V. Localization of Na-adenosine triphosphatase]. PMID- 4343119 TI - Ultrastructure of the corpus luteum of Antarctic seals during pregnancy. PMID- 4343120 TI - Origin of the Golgi complex in germ cells in the developing ovary of the bat. PMID- 4343121 TI - Cell contacts and smooth muscle bundle formation in tissue transplants into the anterior eye chamber. PMID- 4343122 TI - The ultrastructure of the liver parenchyma of the immature fowl (Gallus domesticus). PMID- 4343123 TI - [Ultrastructure of the normal human endometrium. 3. The endometrial granular stroma cells]. PMID- 4343124 TI - The eyes of Creophilus erythrocephalus F. and Sartallus signatus Sharp (Staphylinidae: Coleoptera). Light-, interference-, scanning electron- and transmission electron microscope examinations. PMID- 4343125 TI - [Mixed mesodermal tumors of the uterus]. PMID- 4343126 TI - [Intraoperative cytological assessment of ovarian tumors]. PMID- 4343127 TI - Plasma cell granuloma (histiocytoma) of the lung and pleura. Report on three cases. PMID- 4343128 TI - Influence of age and sex and of castration on renin substrate of normal and nephrectomized rats. PMID- 4343129 TI - Relation between renin substrate and acute phase proteins. Studies of normal and adrenalectomized rats. PMID- 4343130 TI - Transformation by polyoma virus and simian virus 40. PMID- 4343131 TI - Polysaccharides in cancer. PMID- 4343132 TI - The chemistry of mind. PMID- 4343133 TI - Non-beta hormone-producing islet cell tumors of the pancreas. PMID- 4343134 TI - Collagenolytic activity and cancerogenesis in the skin of the newt Triturus cristatus. PMID- 4343135 TI - The fine structure of Micrococcus cyaneus. PMID- 4343136 TI - Chemodectomas of the nasopharynx. PMID- 4343137 TI - Nonchromaffin paraganglioma of the larynx. Case report and review of the literature. PMID- 4343138 TI - Mixed salivary gland tumor of the palate in a child. PMID- 4343139 TI - Tone decay test in neuro-otological diagnosis. PMID- 4343140 TI - Esophageal carcinomas with adenoid cystic differentiation. PMID- 4343141 TI - Fifteen cases of Pendred's syndrome. Congenital deafness and sporadic goiter. PMID- 4343142 TI - Surgical treatment of invasive angiofibroma. PMID- 4343143 TI - A field experiment to assess the role of parainfluenza type 3 virus in pneumonia in a flock of sheep in Victoria. PMID- 4343144 TI - [Enzyme active proteins in human spermatic plasma]. PMID- 4343145 TI - Alveolar cell carcinoma associated with rheumatoid nodule. PMID- 4343147 TI - Hypo- -lipoproteinaemia associated with auto-antibodies against -lipoproteins. PMID- 4343146 TI - [Significance of the ACTH--adrenal gland system in the incidence of increased insulin sensitivity in rats with hypophyseal damage]. PMID- 4343148 TI - Further aspects on the characterization of high and very low density lipoproteins in patients with liver disease. PMID- 4343149 TI - [Dependance of the effect of angiotensin on sympatheticotonia. Studies on conscious individuals]. PMID- 4343150 TI - [Studies on the distribution of enzymes in the endoplasmic reticulum of the liver cell. II. The immunological fractionation of pig liver microsomes]. PMID- 4343151 TI - Protection of some peptides and amino acids by tritylation. PMID- 4343152 TI - Characterization and assay of steroid hormone receptors and steroid-binding serum proteins by agargel electrophoresis at low temperature. PMID- 4343153 TI - [Intracellular localisation of pyruvate carboxylase in chicken liver]. PMID- 4343154 TI - Contribution to the genetics of serum -lipoprotein in man. V. the linkage of Ag x y , Ag a1-d and Ag c-g loci. PMID- 4343155 TI - Enzymes that destroy blood group specificity. V. The oligosaccharase of Clostridium perfringens. PMID- 4343156 TI - Active site properties of (aspartic acid 43)-semisynthetic nuclease-T'. PMID- 4343158 TI - The mechanism of Escherichia coli deoxyribonucleic acid polymerase I. Magnetic resonance and kinetic studies of the role of metals. PMID- 4343157 TI - Enzymatic synthesis of cytidine diphosphate 3,6-dideoxyhexoses. VI. Purification to homogeneity and some properties of cytidine diphosphate-D-glucose oxidoreductase, enzyme E 1 and enzyme E 3 . PMID- 4343159 TI - Effects of adenosine nucleosides on adenylate cyclase, phosphodiesterase, cyclic adenosine monophosphate accumulation, and lipolysis in fat cells. PMID- 4343160 TI - Adenylate cyclase activity in Neurospora crassa. I. General properties. PMID- 4343161 TI - Insulin action in isolated rat thymocytes. I. Binding of 125 I-insulin and stimulation of -aminoisobutyric acid transport. PMID- 4343162 TI - Insulin action in isolated rat thymocytes. II. Independence of insulin and cyclic adenosine monophosphate. PMID- 4343163 TI - Mechanisms of the reactions of cytochrome c. Rate and equilibrium constants for ligand binding to horse heart ferricytochrome c. PMID- 4343164 TI - Characterization of the cell surface receptor for the Agaricus bisporus hemagglutinin. PMID- 4343165 TI - Isolation, characterization, and partial purification of a fatty acyl coenzyme A reductase from bovine cardiac muscle. PMID- 4343166 TI - Elevation of cyclic guanosine 3',5'-monophosphate levels in dog thyroid slices caused by acetylcholine and sodium fluoride. PMID- 4343167 TI - The regulation of purine utilization in bacteria. V. Inhibition of purine phosphoribosyltransferase activities and purine uptake in isolated membrane vesicles by guanosine tetraphosphate. PMID- 4343168 TI - Regulation of cell growth by cyclic adenosine 3',5'-monophosphate. Effect of cell density and agents which alter cell growth on cyclic adenosine 3',5' monophosphate levels in fibroblasts. PMID- 4343169 TI - Transients and cooperativity. A slow transition model for relating transients and cooperative kinetics of enzymes. PMID- 4343170 TI - [Solitary intrapulmonary chemodectomas (apropos of 2 cases)]. PMID- 4343171 TI - [Trophoblastic disease. Its chemotherapy]. PMID- 4343172 TI - [Bilateral diffuse nephroblastoma. Considerations on a further case]. PMID- 4343173 TI - Serological investigations with Loa loa antigens. PMID- 4343175 TI - High plasma renin activity and hypokalemia in rabbits with chronic renovascular hypertension. PMID- 4343174 TI - All-night polygraphic studies of nocturnal angina pectoris. PMID- 4343176 TI - Federal medical chiefs on progress and plans. Department of Health, Education, and Walfare. PMID- 4343178 TI - R & D in health care. PMID- 4343177 TI - Research and development in quality assurance. The experimental medical care review organization program. PMID- 4343179 TI - Effects of anaesthetics on the mobility of Dictyostelium discoideum. PMID- 4343180 TI - [Hamburg's disease. Acute necrosing enteritis]. PMID- 4343181 TI - [Effect of various therapeutic methods on the basophil count in peripheral blood and sensitivity to heparin and heparin-like substances in rheumatic fever in children]. PMID- 4343182 TI - [Adenovirus hospital infection in the form of febrile pharyngitis]. PMID- 4343183 TI - [Diagnosis and treatment of sympathetic nervous system neoplasms in children]. PMID- 4343184 TI - Hepatic coma. PMID- 4343185 TI - The effects of phenazinemethosulfate and methylene blue on human platelet phospholipid synthesis. PMID- 4343186 TI - Fusion of erythrocytes by Sendai virus studied by electron microscopy. PMID- 4343188 TI - Rapid serum lipoprotein changes in spider monkeys on short-term feeding of high cholesterol-high saturated fat diet. PMID- 4343187 TI - Effect of zinc on lipid peroxidation in liver microsomes and mitochondria. PMID- 4343189 TI - The effect of cyclic AMP on heme synthesis by rat bone marrow cells. PMID- 4343190 TI - Structural studies on avian myeloblastosis virus: rapid purification and quantitation. PMID- 4343191 TI - Neuroblastoma cell culture: membrane changes during cyclic AMP-induced morphological differentiation. PMID- 4343192 TI - Effect of varying K+ concentrations on phosphorylase activity, lipolysis, and cAMP levels in perfused rat heart. PMID- 4343193 TI - Effects of vasoactive agents and diuretics on isolated superfused interlobar renal arteries. PMID- 4343194 TI - Hyporeactivity to interferon production by double-stranded RNA associated with hyporeactivity to antiviral protection and hyporeactivity to toxicity. PMID- 4343195 TI - Inhibition of ACTH induced cyclic AMP synthesis in isolated rat adrenal cells by NPS-ACTH. PMID- 4343196 TI - The tumor imprint technique for demonstrating SV40 T antigen by immunofluorescence. PMID- 4343197 TI - Hypocholesterolemic effect of human growth hormone in coronary. Prone (type A) hypercholesterolemic subjects. PMID- 4343198 TI - Routine tissue culture of CNS tumors and animal implantation. PMID- 4343200 TI - Old and new concepts of oncogenesis in the nervous system of man and animals. PMID- 4343199 TI - Anaerobic energy metabolism in brain tumors. PMID- 4343201 TI - Enzymic control of sodium- and potassium-active transport in normal and neoplastic rodent astroglia. PMID- 4343202 TI - Hydrolytic enzyme activity in edematous brain adjacent to malignant neoplasia. PMID- 4343203 TI - Histochemical studies on selected enzymes of experimental neuroectodermal tumors. PMID- 4343204 TI - Roentgen therapy in the treatment of brain tumors. PMID- 4343205 TI - Virus-cell relationships in dog brain tumors induced with Schmidt-Ruppin Rous sarcoma virus. PMID- 4343206 TI - Some structural aspects of dog brain tumors induced with the Schmidt-Ruppin strain of the Rous sarcoma virus. PMID- 4343208 TI - Silica gel as a transport medium for Corynebacterium diphtheriae. PMID- 4343207 TI - The use of tissue cultures in the study of brain tumors. PMID- 4343209 TI - Electron microscope studies of radiation-induced degeneration in oocytes of the sexually mature rhesus monkey. PMID- 4343210 TI - [Contractile fibroblasts (myofibroblasts) in the lamina propria of human seminiferous tubules]. PMID- 4343211 TI - Aggravation of broad- disease (type 3 hyperlipoproteinemia) by hypothyroidism. PMID- 4343212 TI - Diphenylhydantoin and an insulin-secreting islet adenoma. PMID- 4343213 TI - The relationship between insulin and apparent glucocorticoid-promoted activation of hepatic glycogen synthetase. PMID- 4343214 TI - The inhibition of plant mevalonate kinase preparations by prenyl pyrophosphates. PMID- 4343215 TI - Hepatic adenyl cyclase: alterations in hormone response during treatment with a chemical carcinogen. PMID- 4343216 TI - Neonatal development of rat kidney adenyl cyclase and phosphodiesterase. PMID- 4343217 TI - Amylase secretion from mouse parotid and pancreas: role of cyclic AMP and isoproterenol. PMID- 4343218 TI - Enzymes of carbohydrate and lipid metabolism in the placenta and liver of pregnant rats. PMID- 4343219 TI - Role of Ca 2+ and cyclic AMP in protein secretion from rat exocrine pancreas. PMID- 4343220 TI - Influence of cyclic 3',5'-AMP on glycolysis in human erythrocytes. PMID- 4343221 TI - [Study of the biphasic characteristic of the response of cortisolemia to impulsive intravenous injection of corticotropin in some endocrine disorders]. PMID- 4343223 TI - [Feeding behavior and relations between individuals in a primitive ant, Amblyopone pluto Gotwald et Levieux]. PMID- 4343222 TI - [Is induced melanisation of feathers in poultry due to the action of a virus?]. PMID- 4343225 TI - Aflatoxin B 1 , a hepatocarcinogen in the infant mouse. PMID- 4343224 TI - Mitochondrial thymidine-deoxyuridine-phosphorylating activity and the replication of mitochondrial DNA. PMID- 4343226 TI - A comparison of polypyrimidine fragments in 28 S ribosomal RNA from rat liver and the Novikoff ascites hepatoma. PMID- 4343227 TI - Presence of antibody against mouse fetal antigen in the sera from C57BL-6 mice immunized with Rauscher leukemia. PMID- 4343228 TI - Heterotransplantation of a human breast carcinoma cell line. PMID- 4343229 TI - Sensitivity of repair-deficient mutants and similar mutants to 4-nitroquinoline 1 oxide, 4-nitropyridine 1-oxide, and their derivatives. PMID- 4343230 TI - The quinacrine fluorescent and Giemsa banding karyotype of the rat, Rattus norvegicus, and banded chromosome analysis of transformed and malignant rat liver cell lines. PMID- 4343231 TI - Ultrastructural and histochemical observations on a transplantable reticuloendothelial tumor in rats. PMID- 4343232 TI - A radioimmunoassay for placental-type alkaline phosphatase. PMID- 4343234 TI - Receptor sites for concanavalin A on human peripheral lymphocytes and on lymphoblasts grown in long-term culture. PMID- 4343233 TI - Characterization of the kinase(s) involved in the phosphorylation of - and -2' deoxythioguanosine. PMID- 4343236 TI - Differences in synthesis and degradation of serum proteins in normal and hepatoma bearing animals. PMID- 4343235 TI - Focal loss of ribonuclease activity in preneoplastic rat liver. PMID- 4343237 TI - Effect of collagenolytic activity in basal cell epithelioma of the skin on reconstituted collagen and physical properties and kinetics of the crude enzyme. PMID- 4343238 TI - Preparation of single-cell suspensions from normal liver, regenerating liver, and Morris hepatomas 9121 and 5123tc. PMID- 4343239 TI - The phenyl - and -L-idopyranosiduronic acids and some other aryl glycopyranosiduronic acids. PMID- 4343240 TI - Structural investigation of water-soluble rapeseed (Brassica campestris) polysaccharides. II. An acidic arabinogalactan. PMID- 4343241 TI - Attachment reaction of rat uterine luminal epithelium. IV. The cellular changes in the attachment reaction and its hormonal regulation. PMID- 4343242 TI - Lysosomes of the arterial wall. I. Isolation and subcellular fractionation of cells from normal rabbit aorta. AB - Smooth muscle cells were dissociated from normal rabbit aorta by incubating the tissue in Hanks' solution containing elastase, collagenase, and hyaluronidase. The isolated cells contained significant amounts of the following acid hydrolases: N-acetyl-beta-glucosaminidase, N-acetyl-beta-galactosaminidase, beta galactosidase, beta-glucuronidase, alpha-mannosidase, beta-glucosidase, acid phosphatase, and cathepsins C and D. The cells were disrupted and fractionated by isopycnic centrifugation on sucrose density gradients in the Beaufay automatic zonal rotor. Lysosomes with a modal density of 1.16 were identified by the distribution of these acid hydrolases and by the latency of N-acetyl-beta glucosaminidase and beta-galactosidase. Other particulate enzymes studied in these sucrose gradients included cytochrome oxidase and monoamine oxidase (mitochondria), 5'-nucleotidase and leucyl-beta-naphthylamidase (plasma membrane), and catalase (? peroxisome). This microanalytical subcellular fractionation technique is applicable to the study of milligram quantities of many other tissues, both normal and pathological. PMID- 4343243 TI - The interaction between Toxoplasma gondii and mammalian cells. II. The absence of lysosomal fusion with phagocytic vacuoles containing living parasites. AB - Electron microscope methods have been used to study delivery of macrophage primary or secondary lysosomal contents to phagocytic vacuoles containing living or dead toxoplasmas. Secondary lysosomes were labeled by culturing the cells in colloidal thorium dioxide (thorotrast) or in ferritin. Acid phosphatase cytochemistry was employed for detection of primary as well as secondary lysosomal constituents. These various lysosomal labels were present in nearly all vacuoles containing toxoplasmas killed with glutaraldehyde, or in vacuoles containing those parasites undergoing degeneration 1 hr after the uptake of living toxoplasmas. In contrast, at times ranging from 1 to 20 hr after infection, no vacuoles containing morphologically normal, apparently viable toxoplasmas were thorotrast or ferritin positive, and only rarely did these vacuoles react for acid phosphatase. In many instances vacuoles containing viable toxoplasmas and no lysosomal markers were situated in the same cell nearby to vacuoles containing degenerating toxoplasmas and lysosomal constituents, thus indicating that the determinants of lysosomal fusion were operating locally in the immediate vicinity of the phagocytic vacuole, and not operating to influence general cell function. Thus, some toxoplasmas are able to prevent the delivery of lysosomal contents, and apparently the phagocytic vacuole provides for these parasites a sheltered microenvironment ideal for their growth. Morphologic evidence indicated that living toxoplasmas altered the phagocytic vacuolar membrane in macrophages, fibroblasts, and HeLa cells. Within minutes after phagocytosis, the vacuole became surrounded by closely apposed strips of endoplasmic reticulum and mitochondria; somewhat later, microvillous protrusions of the membrane into the vacuole were seen. These morphologic features of phagocytic vacuoles containing living toxoplasmas may be of importance in relation to the absence of lysosomal fusion, or they may serve some function in protecting the host cell or in nourishing the parasite. PMID- 4343245 TI - Studies of genetic transmission of murine leukemia virus by AKR mice. II. Crosses with Fv-1 b strains of mice. AB - The transmission of murine leukemia virus (MLV) to hybrids between AKR and Fv 1(b) mice was studied in order to evaluate the effect of the Fv-1 gene on endogenous MLV infection and to attempt to determine if the genetic loci contributed by AKR carry viral genetic determinants. Fv-1 was shown to have a marked suppressive effect on time of appearance of detectable infectious virus and on the titers attained in vivo, but did not affect the ability of the cells to produce virus in vitro after induction with 5-iododeoxyuridine. The host range type of the virus detected in the hybrid mice was almost always of the type carried by AKR, although the low-virus Fv-1(b) parents carry the genome of a different host range type. This finding provides strong, but not conclusive, evidence that the virus-inducing loci of AKR contain MLV genetic determinants. PMID- 4343244 TI - Studies of genetic transmission of murine leukemia virus by AKR mice. I. Crosses with Fv-1 n strains of mice. AB - AKR mice, which regularly contain infectious murine leukemia virus, were mated with four Fv-1(n) strains of mice which show little or no expression of virus. F(1), F(2), and first and second backcross generation hybrids were tested for virus in tail tissue at 2 and 6 wk of age. The segregation data indicate that the AKR mouse contains two unlinked, autosomal, chromosomal loci, either of which suffices to induce detectable levels of infectious virus in Fv-1(n) progeny by 6 wk of age. One of the loci (tentatively referred to as V(1)) is on linkage group I, 25-30 map units from the locus for albino; the gene order tentatively appears to be N(1)-c-Hbb. PMID- 4343246 TI - [Radiological aspects of calcification in multiple tendinous calcifications and chondrocalcinosis]. PMID- 4343248 TI - Prostatic carcinoma: the relationship between histologic grade and incidence of early metastases. PMID- 4343247 TI - Redox balance in the body: an approach to quantitation. PMID- 4343251 TI - The cross sensitivity to radiations, chemical mutagens and heat treatment of x ray sensitive mutants of yeast. PMID- 4343249 TI - ALT: a new factor involved in the synthesis of RNA by Escherichia coli. PMID- 4343250 TI - Mutations affecting uridine monophosphate pyrophosphorylase or the argR gene in Escherichia coli. Effects on carbamoyl phosphate and pyrimidine biosynthesis and on uracil uptake. PMID- 4343252 TI - [Continuous rickets prevention--already in the newborn infant?]. PMID- 4343253 TI - [Constitutional developmental retardations]. PMID- 4343254 TI - Freezing artifacts in frozen-etched Rhizopus arrhizus sporangiospores. PMID- 4343255 TI - Corticosteroids in management of severe, generalized myasthenia gravis. Effectiveness and comparison with corticotropin therapy. PMID- 4343256 TI - The role of skeletal muscle membrane in experimental myopathy. PMID- 4343257 TI - [Herpes infection of the central nervous system. Diagnosis and treatment]. PMID- 4343258 TI - Vitamin A and spermatogenesis in the rat. PMID- 4343260 TI - Curare and pancuronium compared: effects on previously undepressed mammalian myoneural junctions. AB - Curare and pancuronium have multiple effects on previously undepressed rat diaphragm; these include depression of transmitter output and prolongation of the refractory period of prejunctional structures. The effect of curare on motor nerve terminals is greater than that of pancuronium. Both drugs depress postjunctional receptors; but curare, in addition, raises the threshold for the generation of muscle action potentials. In addition, these results raise questions about the validity of statistical methods used to calculate transmitter output. PMID- 4343259 TI - Rous sarcoma virus nucleotide sequences in cellular DNA: measurement by RNA-DNA hybridization. AB - Kinetic analysis of the hybridization of 71S RNA from Prague strain of Rous sarcoma virus with an excess of DNA from virus induced sarcomas indicated the presence of the majority of the viral genome sequences in cellular DNA with a very low average frequency per cell. About one-third of the viral sequences were at least partially complementary to DNA sequences with a higher average frequency on the order of 50 to 100 per cell. Normal chick embryo DNA was distinctly different, but contained sequences at least partially homologous to some fraction of the viral RNA. PMID- 4343261 TI - Spontaneous middle ear muscle activity in man: a rapid eye movement sleep phenomenon. AB - Changes in compliance of the tympanic membrane have been detected in normal human sleep, presumably due to spontaneous contraction of the stapedius and tensor tympani muscles of the middle ear. In the waking state, these muscles generally respond to loud sound (middle ear reflex). Middle ear muscle activity typically erupts before or at the onset of rapid eye movement (REM) sleep and persists throughout the REM period in a discontinuous pattern resembling that exhibited by rapid eye movements. Approximately 80 percent of all nocturnal middle ear muscle activity is contained in REM sleep. Half of the remaining 20 percent occurs in the 10-minute intervals just prior to the onset of REM sleep. Middle ear muscle activity is often associated with other phasic events such as momentary enhancement of electromyogram inhibition, apnea, and K complexes. Rapid eye movements and middle ear muscle activity, though significantly correlated in REM sleep, are not always simultaneous. PMID- 4343262 TI - Some beliefs and practices affecting the health of the aborigines (Orang Asli) of Bukit Lanjan, West Malaysia. PMID- 4343263 TI - [Cutaneous amebiasis]. PMID- 4343264 TI - [Ultrastructure of the ileum in Blatella germanica L. (Dictyoptera). Localisation, origin and composition of intracellular mineralized concretions]. PMID- 4343265 TI - [Autophagosomes in cultivated chicken heart cells]. PMID- 4343266 TI - The detection of alpha-1-fetoprotein. PMID- 4343267 TI - Improved method for measuring quinolinic acid in biological specimens. PMID- 4343268 TI - Thin-layer chromatography of synthetic polydeoxyribonucleotides. 3. PMID- 4343269 TI - Determination of inorganic phosphate in the presence of Triton X-100. PMID- 4343270 TI - Micro assay of ITP pyrophosphohydrolase by liquid scintillation. PMID- 4343272 TI - Use of silkworm endonuclease in sequencing larger oligonucleotides. PMID- 4343271 TI - Purification of the heme peptide of cytochrome c by affinity chromatography. PMID- 4343273 TI - Selenium determination in human serum lipoprotein fractions by neutron activation analysis. PMID- 4343274 TI - New analogs of adenosine-3',5'-cyclophosphate. PMID- 4343275 TI - [Muco-epidermoid tumors of the parotid gland and oral cavity. Apropos of 33 cases. Anatomo-clinical and histochemical study]. PMID- 4343276 TI - Lipid abnormalities in renal disease. PMID- 4343277 TI - The structure of the lower-density lipoproteins of human plasma: newer concepts derived from studies with the analytical ultracentrifuge. PMID- 4343278 TI - Serum lipoprotein patterns in liver and heart disease. PMID- 4343279 TI - A comparison of methods for determining 2,3-diphosphoglyceric acid in blood. PMID- 4343280 TI - Evaluation of rapid screening methods for the detection of abnormal lipid states related to atherosclerosis. PMID- 4343281 TI - Rapid variation of a freshly isolated strain of herpes simplex virus. PMID- 4343282 TI - Membrane matrix disruption by melittin. PMID- 4343283 TI - Nucleotide phosphohydrolase activities of the plasma membranes of embryonic chick liver cells. PMID- 4343284 TI - Age-related changes in membrane lipid content and enzyme activities. PMID- 4343285 TI - Reactivation of a phospholipid-depleted sodium, potassium-stimulated ATPase. PMID- 4343286 TI - Lipid composition of purified fragmented sarcoplasmic reticulum of the rabbit. PMID- 4343287 TI - Type 2 Herpesvirus hominis growth inhibited by rifampicin. PMID- 4343289 TI - [On antiviral antibodies in feces (coproantibodies). IV]. PMID- 4343288 TI - [On antiviral antibodies in colostrum and milk. 3]. PMID- 4343290 TI - [On antiviral antibodies in urine. V]. PMID- 4343291 TI - Chemodectomas of the glomus jugulare. PMID- 4343292 TI - Thorotrast-induced hepatoma. PMID- 4343293 TI - Meningeal melanocytoma ("melanotic meningioma"). Its melanocytic origin as revealed by electron microscopy. PMID- 4343294 TI - Mesodermal mixed tumor of the uterus. A cytologic, histologic, and electron microscopic correlation. PMID- 4343295 TI - Use of chemotherapy as an adjuvant to surgery for bronchogenic carcinoma. PMID- 4343296 TI - Effects of a glucocorticoid on the concentrations of CoA and carnitine esters and on redox state in bovine liver. PMID- 4343297 TI - Proton-relaxation-enhancement studies on the binding to yeast pyruvate kinase of a substrate and effectors. PMID- 4343298 TI - The synthesis of 3-deoxy-5-O-methyloctulosonic acid and its behaviour in the Warren reaction. PMID- 4343299 TI - Structure of the sugar components of the quinocycline complex. PMID- 4343300 TI - Enzyme localization in beef-heart mitochondria. A biochemical and electron microscopic study. PMID- 4343301 TI - Studies on the biosynthesis of the branched-chain sugars from the quinocycline complex. PMID- 4343302 TI - Long-term experiment with canned meat treated with sodium nitrite and glucono delta-lactone in rats. PMID- 4343303 TI - Ultrastructural studies in the nephrotic syndrome of childhood. PMID- 4343305 TI - Hepatitis-associated antigen in hepatocellular carcinoma in Taiwan. PMID- 4343304 TI - Effects of an experimentally induced herpesvirus infection in calves. PMID- 4343306 TI - [Left temporal glioblastoma associated with polyglobulia]. PMID- 4343308 TI - Unwinding of replicating polyoma virus DNA. PMID- 4343307 TI - The mechanism of anion permeation in thorium-treated gallbladder. PMID- 4343309 TI - Denaturation maps of complete and defective simian virus 40 DNA molecules. PMID- 4343310 TI - Allosteric effect of 2'-adenylic acid on the Pseudomonas pyridine nucleotide transhydrogenase. PMID- 4343312 TI - A device for the rapid measurement of molecular model co-ordinates for x-ray crystallography. PMID- 4343311 TI - The electronic structure of the haem iron in haemoglobin Zurich beta 63his-arg. PMID- 4343313 TI - Sonography as a diagnostic aid in the evaluation of abdominal masses in infants and children. PMID- 4343314 TI - Wilms' tumor and hypertension. PMID- 4343315 TI - Cholinergic and non-cholinergic transmission in the medial geniculate nucleus of the cat. AB - 1. Studies involving the electrophoretic administration of antagonists of ACh (atropine, DHbetaE) and cholinesterase inhibitors (neostigmine, physostigmine) to MGN neurones indicate that ACh is an excitatory transmitter in the feline MGN, most probably released from fibres which originate in or traverse the mesencephalon.2. Auditory afferents to the MGN, cortico-geniculate fibres and the excitatory fibres which mediate ;spontaneous' firing of MGN neurones are unlikely to be cholinergic.3. Almost all geniculo-cortical relay cells are excited by ACh, this excitation being mediated by receptors which have both muscarinic and nicotinic properties. The excitation of relay cells by ACh is sometimes preceded or followed by a depression of firing which is resistant to atropine and DHbetaE, but the significance of this depression is unknown.4. The firing of many unidentified MGN neurones is depressed by ACh in the absence of any excitation, and this depression is blocked by both atropine and DHbetaE, and potentiated by anticholinesterases. This type of depression by ACh may be related to cholinergic inhibition, but this possibility has yet to be investigated. PMID- 4343316 TI - Acetylcholine and lobster sensory neurones. AB - Experiments are presented in support of the hypothesis that acetylcholine functions as a sensory transmitter in the lobster nervous system.1. Several different peripheral sensory structures incorporate radioactive choline into acetylcholine. The preparation most enriched in sensory as opposed to other nervous elements (the antennular sense organs of the distal outer flagellum) does not incorporate significant amounts of glutamate, tyrosine or tryptophan into any of the other major transmitter candidates.2. There is a parallel between the distribution of the enzyme choline acetyltransferase and the proportion of sensory fibres in nervous tissue from many parts of the lobster nervous system.3. Isolated sensory axons contain at least 500 times as much choline acetyltransferase per cm of axon as do efferent excitatory and inhibitory fibres.4. Abdominal ganglia and root stumps show a decline in the rate of incorporation of choline into acetylcholine 2 to 8 weeks after severing the first and second roots bilaterally (leaving the connectives and third roots intact). Extracts of the root stumps exhibit a significantly lower level of choline acetyltransferase 2 weeks after this operation.5. Curare and atropine partially block an identified sensory synapse in the lobster abdominal ganglion. PMID- 4343317 TI - Adaptation to square-wave gratings: inhibition between spatial frequency channels in the human visual system. AB - 1. The observation that the detection threshold for a square-wave grating depends only on that of its fundamental was confirmed by showing that adapting to the fundamental spatial frequency caused elevation of the square-wave threshold, to the same extent as the fundamental threshold was elevated by the same adapting pattern. Adapting to the third harmonic frequency had no effect on the square wave threshold.2. Adapting to a square-wave grating should elevate the thresholds for both the fundamental and third harmonic frequencies (Blakemore & Campbell, 1969), and the amount of elevation at each frequency should be predictable from the contrast of that frequency within the square-wave.3. It was found, however, that both the fundamental and third harmonic, when present in the square-wave, were much less effective as suprathreshold adapting stimuli than would be predicted from their effects when viewed in isolation.4. Adapting to a mixture of two sinusoidal gratings (with 3:1 frequency ratio) demonstrated that the fall in adapting power was not due to the higher harmonics of the square-wave nor to nonlinearities in the stimulus display. Similar effects were found when the phase relations of the adapting gratings were changed, showing that the interaction is not a special property of square-waves or of edges.5. It is suggested that the spatial frequency channels subserving the fundamental and third harmonic frequencies inhibit each other when the patterns are some way suprathreshold. At or near threshold, there is no such reciprocal inhibition. PMID- 4343319 TI - Litter size increases in the x-irradiated hamster and its relationship to dose. PMID- 4343320 TI - The fine structure of Bowman's capsule in male C3H-HeJ mice. PMID- 4343318 TI - The chemotherapy of brain tumors. Clinical experience with carmustine (BCNU) and vincristine. PMID- 4343321 TI - Laboratory maintenance methods for some nectarivorous and frugivorous phyllostomatid bats. PMID- 4343322 TI - A comparison of halothane and methoxyflurane anesthesia in three species of nonhuman primates. PMID- 4343323 TI - Postnatal development of the heart in normal Swiss-Webster mice. PMID- 4343324 TI - Sexual and related territorial behavior in the laboratory rabbit (Oryctolagus cuniculus). PMID- 4343325 TI - Normal serum biochemical values of Cercopithecus aethiops, Cercocebus atys, and Presbytis entellus. PMID- 4343326 TI - Enteropathogenic Escherichia coli infections: increasing awareness of a problem in laboratory animals. PMID- 4343327 TI - Estimation of water consumption by individual mice caged in groups. PMID- 4343328 TI - Growth and hematologic properties of the BALB-wm strain of inbred mice. PMID- 4343329 TI - A preliminary evaluation of Clostridium sp. in the etiology of hamster enteritis. PMID- 4343330 TI - A practical method for production breeding of Chinese hamsters (Cricetulus griseus). PMID- 4343331 TI - Lactic dehydrogenase in lung tissue and plasma of rhesus monkeys. PMID- 4343332 TI - Computer processing of animal housing status and expenditures. PMID- 4343334 TI - An environmental caging system and maintenance program for the nine-banded armadillo, Dasypus novemcinctus. PMID- 4343333 TI - Hemorrhagic-necrotic enteritis in a baboon (Papio cynocephalus) due to Vibrio fetus. PMID- 4343335 TI - Parovarian cyst (hydatid cyst of Morgagni) in a squirrel monkey (Saimiri sciureus). PMID- 4343336 TI - A monkey-proof drinking device for metabolism studies. PMID- 4343337 TI - Anesthesia of the newborn kitten. PMID- 4343338 TI - A device to simplify the rectal probe electro-ejaculation technic for rhesus monkeys. PMID- 4343339 TI - Chirodiscoides caviae infestation in guinea pigs. PMID- 4343340 TI - An automated data acquisition and computer-based computation system for application to toxicological studies in laboratory animals. PMID- 4343341 TI - Growth tables for 66 strains and stocks of laboratory animals. PMID- 4343342 TI - Risk associated with misuse of a rabbit bleeding technic. PMID- 4343343 TI - Less than a mastectomy. PMID- 4343344 TI - [Inhibition of poliovirus synthesis by indole-3-acetic acid at the cellular level]. PMID- 4343345 TI - [The use of synthetic ACTH in the therapy of infantile epilepsy]. PMID- 4343346 TI - Epstein-Barr virus-associated antigens in non-producing clones of human lymphoblastoid cell lines. PMID- 4343347 TI - Observations on the use of methysergide in Huntington's chorea. PMID- 4343348 TI - The effect of intracarotid epinephrine, norepinephrine, and angiotensin on the regional cerebral blood flow in man. PMID- 4343349 TI - [The effect of angiotensin on the kidneys]. PMID- 4343350 TI - Nutritional aspects of alcohol consumption. PMID- 4343351 TI - Insulin and the regulation of protein synthesis in muscle. PMID- 4343353 TI - Report of the Royal Society's British National Committee for Nutritional Sciences. Metric units, conversion factors and nomenclature in nutritional and food sciences. Report of the Subcommittee on Metrication of the British National Committee for Nutritional Sciences. PMID- 4343352 TI - Insulin secretion and food intake. PMID- 4343354 TI - The effect of zinc deficiency on the activity of the adrenal glands. PMID- 4343355 TI - Epidemiological study of the progression of cancer, illustrated by Wilms's tumour. PMID- 4343356 TI - Malignant melanomas in Lymphoedematous arm following radical mastectomy for breast carcinoma (an extension of the syndrome of Stewart and Treves). PMID- 4343357 TI - [Adrenal reserve in schizophrenic patients as based on a synacthen test]. PMID- 4343358 TI - [Mechanisms of hormonal action]. PMID- 4343359 TI - [Suppression by a beta blocking agent of adrenaline-induced hyperglycemia in hypophysectomized dogs]. PMID- 4343360 TI - The branchial gland: a site of haemocyanin synthesis in Octopus. PMID- 4343361 TI - [Enzyme histochemical and fine structural observations on the pecten oculi of the pigeon (Columba livia) and laughing gull (Larus ridibundus)]. PMID- 4343363 TI - The smooth endoplasmic reticulum in regenerating nerve fibers of the anuran Caliptocephalella gayi. PMID- 4343362 TI - Labyrinth cells, a new cell type in vertebrate olfactory organs. PMID- 4343364 TI - [Ultrastructure of the organ of Gabe in Schizophyllum sabulosum L. (Diplopoda, Iuliformia)]. PMID- 4343365 TI - [Exocytosis in the anterior pituitary gland]. PMID- 4343366 TI - Inhibition of noradrenaline-induced lipolysis in hypothyroid subjects by increased -adrenergic responsiveness. An effect mediated through the reduction of cyclic AMP levels in adipose tissue. PMID- 4343367 TI - Noradrenaline-induced lipolysis in subcutaneous adipose tissue from hypothyroid subjects. The relation of noradrenaline response to the degree and duration of the disease. PMID- 4343368 TI - [The giant cell reaction]. PMID- 4343369 TI - [Ultrastructural study of a tumor of the caudate nucleus in a case of Bourneville's disease]. PMID- 4343370 TI - Mechanism of resistance to virus challenge in mice infected with Brucella abortus. PMID- 4343371 TI - Studies of human cytomegalovirus strain variations by kinetic neutralization tests. PMID- 4343372 TI - The synthesis of viral- and cellular-DNA in mammalian cells exposed to polyoma virus. PMID- 4343373 TI - Biologic and immunologic comparison of two plaque variants of herpes simplex virus type 1. PMID- 4343374 TI - Primary reninism. Hypertension, hyperreninemia, and secondary aldosteronism due to renin-producing juxtaglomerular cell tumors. PMID- 4343375 TI - Hypopituitarism in acromegaly. PMID- 4343376 TI - Sleep and cardiac arrhythmias. PMID- 4343377 TI - The auto-immunogenicity of articular cartilage. PMID- 4343378 TI - [Different effects of early thymectomy on the development of transplanted mammary neoplasms in relation to the presence of the milk factor in the recipients]. PMID- 4343380 TI - The histidines in liver alcohol dehydrogenase. Chemical modification with diethylpyrocarbonate. PMID- 4343379 TI - [Studies on intestinal 47 Calcium absorption in healthy subjects and patients with chronic renal failure as well as on the significance of vitamin D 3 or 25 hydroxycholecalciferol therapy in renal osteopathy]. PMID- 4343381 TI - [Hydrocephalus: the radiology of ventriculo-atrial shunts and their complications]. PMID- 4343382 TI - [The normal skull radiograph during the first few months of life]. PMID- 4343384 TI - [The radiological diagnosis of space-occupying, intraspinal lesions in childhood]. PMID- 4343383 TI - [Craniometric examination of skull growth]. PMID- 4343385 TI - [Radiological lung changes in mycoplasma pneumonia]. PMID- 4343386 TI - [The pancreatographic appearance of inflammatory pancreatic disease]. PMID- 4343387 TI - [Extraction of residual gallstones without reoperation]. PMID- 4343388 TI - [Extravasation from fornix rupture during infusion urography]. PMID- 4343389 TI - [Urography using high doses of contrast media by rapid injection or as infusion urography. Diagnostic value and frequency of complications]. PMID- 4343391 TI - [Lymphographic appearances of retro-peritoneal fibrosis]. PMID- 4343390 TI - [Angiographic demonstration of arteriovenous shunts in dialysis patients]. PMID- 4343392 TI - [Renal scanning with 131 I-o-iodohippuric acid for the demonstration of highly vascular renal tumours and possible sources of misinterpretation]. PMID- 4343393 TI - [Estimation of glomerular filtration rates with 169 Yb-EDTA and effective renal plasma flow with 131 I-Hipuran]. PMID- 4343394 TI - [Equidensities with chromogenic development in angiography]. PMID- 4343395 TI - [Is equidensity film applicable to the evaluation of encephalograms?]. PMID- 4343397 TI - [A simplified method for photographic subtraction using a 90 second processer]. PMID- 4343396 TI - [Experience with photo-subtraction using a mechanical subtration method]. PMID- 4343398 TI - [Significance of angiographic examinations in the diagnosis of pheochromocytoma with poor symptoms]. PMID- 4343399 TI - [Arterial circulatory disorders of the arm as a late complication of clavicle fracture]. PMID- 4343400 TI - [Infant pneumatosis cystoides intestinalis]. PMID- 4343401 TI - Effect of Friend leukemia virus and Rowson-Parr virus on immunological maturation of mice. AB - The effect of neonatal infection with Friend virus (FV) and Rowson-Parr virus (RPV) on the maturation of the capacity to respond to sheep red cells, as measured by the numbers of hemolytic plaque-forming cells in the spleen, was investigated in BALB/c mice. Both viruses affected immunological maturation but there were significant differences between their effects. The development with age of the ability to produce plaque-forming cells in response to antigen was virtually abolished by FV and only slightly impaired by RPV. Furthermore, FV also suppressed the development of background plaque-forming cells, whereas RPV did not. PMID- 4343402 TI - Epicillin: in vitro laboratory studies. AB - A new semisynthetic penicillin, structurally related to ampicillin, has been assigned the generic name epicillin, 6-[d-2-amino-2-(1, 4-cyclohexadienyl) acetamido]-penicillanic acid. The antimicrobial spectrum and level of activity of epicillin in vitro are similar to those of ampicillin. In studies with recent clinical isolates, these two antibiotics, when compared with carbenicillin, showed consistently higher antimicrobial activity against Staphylococcus aureus, Streptococcus pyogenes, Escherichia coli, and Proteus species. When tested against Pseudomonas aeruginosa isolates, on the other hand, epicillin exhibited a level of intrinsic activity superior to that of ampicillin but less than that of carbenicillin. Epicillin is an amphoteric substance that is sensitive to penicillinase, is acid-stable, and is minimally, but reversibly, bound to human serum protein. PMID- 4343403 TI - Biological characteristics of Clostridium perfringens type A enterotoxin. AB - An enterotoxin with the ability to induce fluid accumulation in rabbit ileal loops, erythema in the skin of guinea pigs, and lethality in mice appears in cell extracts (CE) and culture filtrates (CF) of sporulating cells of some Clostridium perfringens type A strains. All activities in CE and CF were eluted simultaneously from a Sephadex G-200 column. Different elution patterns were obtained for these activities present in CE and CF. Rabbit immune serum against CF and the active CE fractions eliminated the three biological activities in CE and CF. These activities present in CF and CE were not eliminated by any of the known antitoxins present in diagnostic serum against C. perfringens types A, B, C, D, and E. Immunodiffusion studies with immune serum against active CE fractions and CF indicated a precipitin line of identity between CF and CE of NCTC 8798 and other enterotoxin-positive strains but not enterotoxin-negative strains. Disc electrophoresis of active G-200 fractions on 7.0% polyacrylamide gels revealed a single area containing erythemal activity and mouse lethality. Immunodiffusion with acrylamide gels, containing crude fractionated enterotoxin, and immune serum against partially purified enterotoxin revealed a single precipitin band in the same area as the biological activities. Immunoelectrophoresis of CE of enterotoxin-positive and enterotoxin-negative strains also showed one precipitin band which occurred only with enterotoxin positive strains. These findings suggest that one component is responsible for the biological activities attributed to the enterotoxin. PMID- 4343404 TI - Specific secondary biological properties of purified rabbit immunoglobulin M and immunoglobulin G antibodies to Brucella abortus and Bordetella pertussis. AB - Rabbit immunoglobulin (Ig)M and IgG antibodies to Brucella abortus and Bordetella pertussis were isolated as purified products and their specific secondary biological activities were compared. IgM antibodies were found to be more active than IgG proteins in inducing agglutination and sensitization of B. abortus for the complement-dependent bactericidal effect and in inhibiting B. pertussis induced lymphocytosis in the mouse. IgM and IgG antibodies were found to be equally effective in inducing agglutination of B. pertussis suspended in a colloidal solution. These data parallel previous work to indicate that IgM antibodies to bacterial surface antigens are more efficient than IgG molecules in initiating biological processes concerned with the inactivation of these pathogens. PMID- 4343405 TI - Hemopoietic colony-forming cell responses in mice infected with ectromelia virus. AB - The responses of in vitro colony-forming cells (granulocyte-macrophage progenitor cells) were studied in the bone marrow, spleen, and blood of mice after intraperitoneal injection of 10(3) plaque-forming units of ectromelia virus. This study showed that a colony-forming cell response occurred during infection and was accompanied by an increase in the serum level of colony-stimulating factor and, at a later stage, colony-inhibiting factor. Changes in the proportions of colony-forming cells were not due to relative changes in other cell populations. The relationships between colony-forming cell responses and levels of infection were complex, higher levels of infection being associated with good colony forming cell responses in bone marrow and apparently poor colony-forming cell responses in blood and spleen. PMID- 4343406 TI - Role of hemopoietic colony-forming cell responses in the pathogenesis of ectromelia. AB - Intraperitoneal injection of complete Freund's adjuvant which caused an extensive cellular response in the reticuloendothelial system greatly increased the severity of infection which resulted from footpad inoculation of ectromelia virus in mice. The mortality was greatest during the proliferative phase of the cellular response, indicated by the colony-forming cell response. Exposure of colony-forming cells to virus in vitro showed that those from normal bone marrow were much less susceptible to virus than those from the bone marrow of adjuvant treated mice and more particularly those from the spleen of adjuvant-treated mice. Severe bleeding to induce anemia and a consequent erythropoietic response did not increase the mortality from ectromelia. Previous results were interpreted on the basis of these findings and a more general application of them to the pathogenesis of poxvirus infection was discussed. PMID- 4343407 TI - Epidemiology of a herpesvirus of turkeys: possible sources and spread of infection in turkey flocks. AB - Parameters of turkey herpesvirus (HVT) infection were followed sequentially from hatching through 20 weeks in two commercial turkey flocks. Maternal antibody was uniformly present at hatching but decreased below detectable levels by the 3rd week. Virus was first isolated at the 5th and 6th weeks and thereafter spread rapidly within the flocks. Development of active antibody followed that of viremia by 1 week. Both virus and antibody were present in virtually all turkeys after the 7th or 10th week; however, the incidence of tumors was negligible. Dust and litter from infected flocks were negative for HVT by poult bioassay, but the infection was easily transmitted by exposure of poults to dirty isolation cages or air from HVT-infected turkeys. Attempts to demonstrate congenital transmission of HVT by direct virus isolation from embryos of infected breeders or by isolation rearing procedures were unsuccessful. PMID- 4343408 TI - Neutralizing antibodies to cytomegaloviruses in normal simian and human sera. AB - Simian and human sera were examined for neutralizing antibodies to simian and human cytomegaloviruses (CMV). Neutralizing antibody to simian CMV was found in sera from 12 of 12 African green monkeys, 8 of 10 rhesus monkeys, and 7 of 7 baboons captured in the wild. The antibody did not cross-react with human CMV strain AD169 but cross-reacted with human strain C87, particularly in the presence of complement. Thirty-six baboons and 10 rhesus monkeys born and hand reared in captivity remained free of neutralizing antibody both to simian and human CMV for as long as 4 years. Fifteen of 24 human sera (63%) revealed only species-specific neutralizing antibody. PMID- 4343409 TI - Comparison between the polymyxins and gentamicin in preventing endotoxin-induced intravascular coagulation and leukopenia. AB - Three antimicrobial agents were evaluated as to their ability to neutralize the toxic effects of endotoxin in rabbits. These consisted of two cyclic polypeptides, polymyxin B sulfate and colymycin M (sodium colistimethate), and an aminoglycoside, gentamicin sulfate. Polymyxin B regularly prevented endotoxin induced leukopenia, thrombocytopenia, and disseminated intravascular coagulation. Colymycin M had similar activity but was not as effective as polymyxin B. Gentamicin demonstrated no neutralizing ability in this study. PMID- 4343410 TI - Enhancement of phagocytosis by interferon-containing preparations. AB - Exposure of mononuclear cells from the mouse peritoneal cavity to interferon (IF) containing mouse sera enhanced phagocytosis of colloidal carbon particles by the cells. The same effect was observed when the cells were exposed to IF-containing cell culture harvest free of serum. The magnitude of this effect of IF-containing preparations paralleled the titer of IF and was not related to the dilution of various IF-containing serum specimens tested. The factor responsible for the enhancing effect was stable at pH 2, inactivated by trypsin, and nonsedimentable at 105,000 x g. Heating at 60 C for 1 hr destroyed it, and its kinetics of heat inactivation paralleled that of the antiviral activity of IF. A period of incubation of phagocytic cells with IF-containing serum was necessary before a maximum level of enhancement was reached, and once established was not removable by repeated washing of cells. The kinetics of the production of the enhancing factor in mice injected with Newcastle disease virus was essentially identical to that of the simultaneous production of IF as measured by antiviral activity. Contrary to the effect of mouse IF preparations, human IF preparation did not enhance the activity of mouse phagocytes. It appears, therefore, that the phagocytosis-enhancing factor falls within the present definition of IF. PMID- 4343411 TI - Classification of North American porcine enteroviruses: a comparison with European and Japanese strains. AB - Seventy-two strains of porcine enteroviruses including strains from North America, England, and Japan were compared by cell culture neutralization tests to provide a serological classification of North American strains. From the tests, eight serogroups evolved, with serogroup 8 having a possible three subgroups. There appeared to be some intergroup relationship among certain viruses in groups having the same specific cytopathic effect (CPE) in cell culture. There was no apparent cross-reaction between the group with type II CPE and groups with type I CPE. Antisera produced in nonhost chickens provided a satisfactory antibody source for the tests. It was proposed that satisfactory typing of viruses could be done best by cross-neutralization rather than by one-way neutralization tests. This provided the homologous serum titer as determined in the laboratory conducting the tests which was important where comparisons are made on the basis of per cent of the homologous titer. It was further emphasized that viruses of tissue origin and their antisera have fewer intergroup reactions than viruses of intestinal origin and their antisera. General type strains and specific North American strains were suggested as satisfactory type sera and viruses for seven of the eight groups to facilitate virus identification. PMID- 4343412 TI - Antiviral immune cytolysis at an early stage of paramyxovirus infection. AB - Antiviral antibody and rabbit complement added as early as 5 min after infection, and with relatively low virus/cell multiplicity, lysed mouse ascites lymphoma cells infected with Sendai or Newcastle disease virus. Inactive Sendai virus at much higher input also sensitized ascites cells and mouse fibroblast monolayers to early antiviral immune cytolysis. At 4 C where adsorption but no penetration occurred, antibody removed virus from the cell membrane and little cytolysis was observed. The ascites cells were sensitive to antibody and complement at all times after the start of penetration and uncoating, indicating that viral envelope antigen is constantly present on the cell membrane. Significant cross reactions by immune cytolysis between Newcastle disease virus- and Sendai virus infected cells suggested possible participation of host antigens of the viral envelope. No comparable antiviral immune cytolysis was observed with influenza strains PR8 and WSN. Cell viability was estimated by dye exclusion and the ability to form acid from glucose as indicated by colorimetric pH of the medium. The relation of antiviral immune cytolysis to changes in the membrane resulting in cell fusion is considered. PMID- 4343414 TI - Influence of angiotensin I, angiontensin II and cocaine on adrenergic vasoconstrictor responses in the dog hindpaw. PMID- 4343413 TI - Electron microscopy of group A streptococci after phagocytosis by human monocytes. AB - Group A streptococci were added to cultures of isolated human blood monocytes. The bacteria were readily sequestered within phagocytic vacuoles after being coated with flocculent material, apparently derived from the plasma-containing medium. Progressive lysis of intravacuolar streptococci was observed, characterized by plasmolysis, internal disruption, and eventual plasma membrane dissolution. However, the cell walls remained essentially identical to those of nonphagocytized streptococci, showing no signs of dissolution within the limited in vitro survival time of the monocytes. These results indicate that streptococcal cell walls may persist in migrating human phagocytes in vivo and may be deposited in body tissues. This cell wall material, known to be toxic to animal tissues, may be an important determinant in the pathogenesis of poststreptococcal sequelae in man. PMID- 4343415 TI - Estimation of the dissociation constant of d-tubocurarine and the receptor for endogenous acetylcholine. PMID- 4343417 TI - The general practitioner and the Abortion Act. PMID- 4343416 TI - The distribution and binding of tritiated polymyxin B in the mouse. PMID- 4343418 TI - Cultured human lymphocytes. PMID- 4343419 TI - A murine polycythemic virus and its possible role in the study of human leukemia etiology. PMID- 4343420 TI - The question of "preneoplastic" lesions. PMID- 4343421 TI - Autocorrelation and spectrum of the modulated retinal discharge. A comparison of theoretical and experimental results. PMID- 4343422 TI - [Influence of Bordetella pertussis on the lymphatic tissue of mice. VII. Studies on the relationships between the various biological effects induced by Bordetella pertussis]. PMID- 4343423 TI - Properties of the infectious bursal agent of chicken (IBA). PMID- 4343425 TI - Motor neuropathy associated with herpes zoster. PMID- 4343424 TI - [Virus infected lymphoblasts acting as antigen for the production of heterologous antilymphocyte sera]. PMID- 4343426 TI - Adenosine 3',5'-monophosphate concentrations and isoproterenol-induced synthesis of deoxyribonucleic acid in mouse parotid gland. PMID- 4343428 TI - [Cylindroma of the middle ear]. PMID- 4343427 TI - Mode of action of tylocrebrine: effects on protein and nucleic acid synthesis. PMID- 4343429 TI - The Dandy-Walker syndrome. A clinicopathological study based on 28 cases. PMID- 4343430 TI - Glucose-dependent, pH-sensitive insulin effect on the motor nerve terminal. PMID- 4343431 TI - Tortuous vertebrobasilar system: a cause of cranial nerve signs. PMID- 4343432 TI - [Essential permanent arterial hypertension. Probability of a neurogenic factor]. PMID- 4343433 TI - [Role of magnesium, potassium, antikaliuretic agents and hypocholesteremic agents in cardiac lesion development in rats fed a thrombogenic diet and Na 2 HPO 4 ]. PMID- 4343434 TI - Sensory mechanisms in dentine. PMID- 4343435 TI - Some recent advances in anterior filling materials. PMID- 4343436 TI - [Urinary hydroxyproline correlated with quantitative bone histological data. Attempted physiopathological interpretation]. PMID- 4343437 TI - [Value of pulmonary scanning in an intensive care unit]. PMID- 4343438 TI - [Occlusive thrombosis of the left atrium. Apropos of a case]. PMID- 4343439 TI - [Cancer of the parathyroids. Apropos of a case]. PMID- 4343440 TI - [Severe diabetes mellitus and hypokaliema revealing adrenocortical tumors]. PMID- 4343441 TI - [Multiple stenoses of the medium size cerebral arteries and abnormal capillary networks (moya moya). Nosological problems]. PMID- 4343442 TI - [Digestive localizations of scleroderma and malabsorption]. PMID- 4343443 TI - Hematologic abnormalities in rheumatoid arthritis. PMID- 4343444 TI - Gallium-67 scintigraphy in lung diseases. PMID- 4343445 TI - An evaluation of brush biopsy in the diagnosis of peripheral pulmonary lesions. PMID- 4343446 TI - Methotrexate pneumonitis: case report and review of the literature. PMID- 4343448 TI - [Vibration disease in workers manufacturing glassware]. PMID- 4343447 TI - Inappropriate antidiuretic hormone secretion in oat-cell carcinoma of bronchus. Aggravation of hyponatraemia by intravenous cyclophosphamide. PMID- 4343449 TI - [Clinical course of pneumonias of viral, mycoplasmic and bacterial etiology]. PMID- 4343450 TI - [Clinico-epidemiological and virological characteristics of adenovirus infection outbreaks]. PMID- 4343451 TI - [Immediate and remote results of intravenous chemo-hormonotherapy of initially detected pulmonary tuberculosis]. PMID- 4343452 TI - [Various characteristics of pyrophosphate splitting enzymes from Candida utilis]. PMID- 4343453 TI - [Ultrafine structure of Mycobacterium tuberculosis]. PMID- 4343454 TI - Prostaglandins. PMID- 4343455 TI - Assembly of viruses. PMID- 4343456 TI - Structure and metabolism of connective 801 tissue proteins. PMID- 4343457 TI - Serum lipoproteins structure and function. PMID- 4343459 TI - Choline acetyltransferase and acetylcholinesterase. Their role in the causes of myasthenia gravis. PMID- 4343458 TI - Myeloma neuropathy. Successful treatment of two patients and review of cases. PMID- 4343460 TI - Metabolism of cytidine diphosphate diglyceride in ataxic rabbit brain. PMID- 4343461 TI - Ultrastructural changes in dog brains immediately following non-pulsatile extracorporeal circulation and prolonged anaesthesia. PMID- 4343462 TI - Resistance to intracerebral challenge in mice immunized against herpes simplex virus. PMID- 4343463 TI - Tumours of the salivary glands. PMID- 4343464 TI - Pulmonary aspiration after fibre-endoscopy of the upper gastrointestinal tract. AB - Pulmonary aspiration occurred in 16 out of 65 patients (24.6%) undergoing fibre endoscopic examinations of the upper gastrointestinal tract under intravenous sedation, but it was rarely followed by serious complications. Aspiration was found to occur under sedation with diazepam alone, diazepam with atropine, and with chlormethiazole. The most important factors contributing to aspiration are the local pharyngeal anaesthesia and the mechanical interference of the fibrescope with laryngeal closure and swallowing. The patient is also at risk of aspiration after completion of the procedure and should remain recumbent until the local anaesthesia has worn off. PMID- 4343465 TI - Mineralization in the chick embryo. I. Monohydrogen phosphate and carbonate relationships during maturation of the bone crystal complex. PMID- 4343466 TI - The further purification and characterization of mouse bone collagenase. PMID- 4343467 TI - Semi-on-line implementation of an alias-free sampling system for neuronal signals. PMID- 4343468 TI - [Status of cerebral angiography]. PMID- 4343469 TI - Classification of congenital malformations of the hand and upper extremity. PMID- 4343470 TI - Ultrastructure of transplantable mouse hepatomas with different growth rates. PMID- 4343471 TI - Antitumor effects of antibody-diphtheria toxin conjugates: use of hapten-coated tumor cells as an antigenic target. PMID- 4343472 TI - Studies on the in vivo replication of turkey herpesvirus. PMID- 4343473 TI - Murine virus contaminants of leukemia viruses and transplantable tumors. PMID- 4343474 TI - "Spontaneous" neoplastic transformation in vitro: influence of endogenous murine leukemia virus and serum fractions. PMID- 4343475 TI - Lack of pathogenicity of Marek's disease virus and herpesvirus of turkeys in marmoset monkeys. PMID- 4343476 TI - Hormone dependency of murine endocrine tumors in vivo and in organ culture: a correlative study. PMID- 4343477 TI - Mouse leukemia: a model of a multiple-gene disease. PMID- 4343478 TI - Acute leukemia in identical twins: search for viral and leukemia-associated antigens. PMID- 4343479 TI - Voluntary and reflex control of the biceps brachii muscle in spastic-athetotic patients. AB - A cross-correlation technique of analysis was used to measure the transmission characteristics of tonic stretch reflex (TSR) pathways in spastic-athetoid subjects sustaining a voluntary contraction in the biceps brachii muscle. A comparison was made with the transmission characteristics of normal subjects measured by the same technique. It was found that gain and phase characteristics of spastic patients did not display the large resonant peaks present in normals. It is proposed that the resonant peaks in the TSR transmission of normal subjects were caused by long loop pathways. The absence of these peaks in the spastic patients supports the hypothesis that short-circuiting of long loop pathways by hyperactive spinal reflexes is part of the mechanism of spasticity. PMID- 4343480 TI - Electrophysiological evidence for a distal lesion in alcoholic neuropathy. AB - Nerve conduction studies were carried out on 16 alcoholic subjects with minimal or no clinical evidence of peripheral neuropathy. Digital nerve action potentials recorded at the base of the finger were reduced in amplitude in five but the potential at the wrist was reduced in only one. In two other patients, even though the values were within the control range, the ratio of the amplitude recorded from the finger and from the wrist was smaller than in control subjects. Thus, by recording both digital and wrist action potentials, abnormalities have been demonstrated in seven of 16 patients, whereas the wrist potential was abnormal in only one. Conduction velocity was slightly reduced in the fingers in three patients. PMID- 4343481 TI - Malignant glioma of the brain-stem. A clinicopathological analysis of 13 cases. AB - Thirteen cases of malignant glial tumours of the brain-stem that came to necropsy have been analysed in detail. These patients followed a rather uniform course defined by the early onset of signs and symptoms of increased intracranial pressure, poor response to radiotherapy, and short total duration of illness. Pathological features were also similar in all cases, with each tumour showing areas ranging from benign to frankly malignant. This regional variability points to the limited usefulness of small biopsies and also indicates the need for complete necropsy studies. The term 'spongioblastoma polare' should probably be avoided, and it is suggested that the histological classification of glial brain stem tumours be similar to the classification of such tumours elsewhere in the neuraxis. PMID- 4343482 TI - Problems arising from blanks in protein-binding analysis. PMID- 4343483 TI - Receptors and binding of androgens in the prostate. PMID- 4343484 TI - Structural recognitions in the interactions of androgens and receptor proteins and in their association with nuclear acceptor components. PMID- 4343485 TI - Studies on the interaction between androgen and macromolecules in male accessory sex organs of rat and man. PMID- 4343486 TI - Estrophile to nucleophile in two easy steps. PMID- 4343487 TI - Mechanism of estrogen action studies in the human. PMID- 4343489 TI - The interaction of uterine estrogen receptors with DNA. PMID- 4343488 TI - Metabolism of androgens by isolated human hair follicles. PMID- 4343490 TI - Mineralocorticosteroid receptors in the foetal compartment. PMID- 4343491 TI - Aldosterone: mechanism of action on isolated sodium-transporting epithelia. PMID- 4343492 TI - Glucocorticoid-receptor complexes and the earliest steps in the action of glucocorticoids on thymus cells. PMID- 4343493 TI - Model studies with erythrocytes on the initial steps of cellular uptake and binding of steroids. PMID- 4343494 TI - Progesterone receptor components: identification of subunits binding to the target-cell genome. PMID- 4343495 TI - Studies in the formation and degradation of adenosine 3',5'-cyclic monophosphate in corpus luteum. PMID- 4343496 TI - A sex difference in the prevalence of antibodies to cytomegalovirus. PMID- 4343497 TI - Lysolecithin acyltransferase in hamster intestinal mucosa. PMID- 4343499 TI - [Enzymological diagnosis of chronic hepatitis]. PMID- 4343500 TI - [Chemical purification of drinking water]. PMID- 4343498 TI - Relationship between embryonic and tumor lipids. I. Changes in the neutral lipids of the developing chick brain, heart and liver. PMID- 4343501 TI - Herpesvirus hominis antibody in multiple sclerosis and amyotrophic lateral sclerosis. PMID- 4343502 TI - Inefficacy of fresh frozen plasma therapy of mucopolysaccharidosis II. PMID- 4343503 TI - Thiamine-responsive lactice acidosis in a patient with deficient low-KM pyruvate carboxylase activity in liver. PMID- 4343504 TI - Growth hormone response to exercise. A test of pituitary function in children. PMID- 4343505 TI - [The architecture and organization of the Chlamydomonas cell. Results of serial section electron microscopy and a three-dimensional reconstruction]. PMID- 4343506 TI - [Respiratory virus infections in Rio Grande do Sul. I. Isolation and identification of the agent]. PMID- 4343507 TI - [Respiratory viral infections in Rio Grande do Sul. II. Serological surgery]. PMID- 4343508 TI - The glomus tumor. PMID- 4343509 TI - [Rare glandular tumours of the external ear canal]. PMID- 4343510 TI - [The so-called vestibular recruitment]. PMID- 4343511 TI - Instrumentation in clinical chemistry. PMID- 4343512 TI - [The free space of synchronous Chlorella]. PMID- 4343513 TI - Synthesis of albumin by the free polyribosomes in 5123 hepatoma. PMID- 4343514 TI - Study of extracts of barley grain infected with Fusarium sporotrichioides No. 63. AB - Experiments with mice showed that an aqueous extract of barley grain attacked by by Fusarium sporotrichioides is blastomogenic, but only mildly so. PMID- 4343515 TI - Electron paramagnetic resonance study of single crystals of horse heart ferricytochrome c at 4.2 degrees K. PMID- 4343516 TI - Stimulation of onset of the phase of rapid hemoglobin formation in the chick blood islands by the wax fraction of egg yolk. PMID- 4343517 TI - Hormonal relase by dispersed pituitary cells. PMID- 4343518 TI - Presence of -lipoprotein in serum of patients treated for acrodermatitis enteropathica (Danbolt's disease). PMID- 4343519 TI - Locating brain tumours through depth EEG probes. PMID- 4343521 TI - Reversible blockage of specific synaptic transmission by localized and moderate cooling with a vacuum insulated probe connected to a closed circuit apparatus. PMID- 4343520 TI - Intrathalamic and intraventricular application of hydrocortisone during stereotactic operations. PMID- 4343522 TI - Plasma renin activity (PRA) in Parkinson's disease before and after stereotaxic operation. PMID- 4343523 TI - [Psychophysiologic approach to dream recall]. PMID- 4343524 TI - [Assessment of ACTH activity of the hypophysis through quantitative determination of adrenal gland ascorbic acid using paper chromatography]. PMID- 4343525 TI - High interferon producing line of transformed murine cells. PMID- 4343526 TI - Effect of plasma membrane lipid composition on cellular susceptibility to virus induced cell fusion. PMID- 4343528 TI - The density of poliovirus-specific polysomes. PMID- 4343527 TI - Specific inhibition of poliovirus induced blockade of cell protein synthesis by a thiopyrimidine derivative. PMID- 4343530 TI - [Characterization of viruses obtained after cell fusion or transfection of chicken cells with DNA from virogenic mammalian rous sarcoma cells]. PMID- 4343529 TI - Immunological specificity of the glycoproteins of herpes simplex virus subtypes 1 and 2. PMID- 4343531 TI - Synthesis in vitro by bacterial RNA-polymerase of simian virus 40-specific RNA: multiple transcription of the DNA template into a continuous polyribonucleotide. PMID- 4343532 TI - Studies on the cytopathogenicity of Newcastle disease virus: effect of lectins on virus infected cells. PMID- 4343534 TI - Inosine incorporation into myocardial nucleotides. PMID- 4343533 TI - Studies on plasma membranes. 18. Lipid class composition of plasma membranes isolated from rat and mouse liver and hepatomas. PMID- 4343535 TI - The effect of adenosine on cardiac cells in culture. PMID- 4343536 TI - Effect of insulin on pyruvate and glucose metabolism of beating mouse heart cells. PMID- 4343537 TI - An effect of ouabain on isolated heart tissue from cardiomyopathic Syrian hamsters. PMID- 4343538 TI - Separation of the herpesvirus deoxyribonucleic acid duplex into unique fragments and intact strand on sedimentation in alkaline gradients. AB - Deoxyribonucleic acid (DNA) extracted from herpes simplex virions forms multiple partially overlapping bands upon denaturation and centrifugation in alkaline sucrose density gradients. The most rapidly sedimenting DNA corresponds to an intact strand 48 x 10(6) daltons in molecular weight. In this study, we analyzed the DNA fragments generated in alkaline sucrose gradients with respect to size and uniqueness of base sequences. The distribution of sedimentation constants of the various fragments obtained in numerous gradients showed that the fragments smaller than the whole strand fall into six distinct classes ranging in molecular weight from 10 x 10(6) to 39 x 10(6) daltons. Four types of DNA strands can be reconstructed from the whole strand and six fragments on the basis of their molecular weights. DNA from each of the bands self-hybridizes to a lower extent than unfractionated viral DNA, indicating that each of the bands preferentially contains sequences from one unique strand. The data permit reconstruction of four possible types of DNA duplexes differing in the positions of the strand interruptions. Analysis of viral DNA extracted from nuclei of cells labeled with (3)H-thymidine for intervals from 3 to 120 min showed that nascent DNA is invariably attached to small fragments and that the fragments become elongated only upon prolonged incubation of cells. The experiments suggest that viral DNA replication begins at numerous initiation sites along each strand and that the elongation beyond the size of the replication unit involves repair or ligation, or both. Since newly made DNA yields more fragments than viral DNA extracted from mature virions, it is suggested that the fragmentation of mature DNA on denaturation with alkali arises from incomplete processing of specific initiation sites. Comparison of viral DNA extracted from nuclei with that extracted from mature cytoplasmic virions in cells labeled for 120 min indicates that packaged DNA is not randomly selected from among the nuclear DNA population but rather represents DNA molecules which in alkaline gradients yield a minimal number of fragments. PMID- 4343539 TI - Growth characteristics of Kilham rat virus and its effect on cellular cellular macromolecular synthesis. AB - Kilham rat virus (KRV) is adsorbed into the rat nephroma cell within 1 hr after infection. There follows a latent period of about 12 hr during which less than 1% of the input infectious virus can be accounted for. New infectious virions can be detected at about 12 hr and the maximal yield of virus is attained by 23 hr after infection. The increase in final virus yield is about 200-fold over that found in the latent period. During this 23-hr period of virus growth, the rate of protein synthesis remains 75 to 100% of that in the uninfected cell. Ribonucleic acid (RNA) synthesis during this period is maintained at 100 to 150% of that found in the control cells. The addition of the inhibitor of deoxyribonucleic acid (DNA) synthesis, 5-fluoro-deoxyuridine (FUDR), up to 8 hr after infection completely suppresses virus production. After 8 hr, viral DNA production has started and FUDR inhibition progressively decreases until by 23 hr the addition of the inhibitor no longer causes a reduced virus yield. Viral DNA synthesis once initiated is required for the remainder of the 23-hr virus cycle. Viral DNA synthesis probably begins about 4 hr before the production of infectious virions. In the KRV-infected cells, DNA synthesis decreased sharply for 6 to 7 hr after infection in comparison to the uninfected cell. At 7 to 8 hr after infection, DNA synthesis in the infected cell increased and was maintained at a higher level than in the control cells for the rest of the virus growth period. PMID- 4343540 TI - Effect of vesicular stomatitis virus infection on the histocompatibility antigen of L cells. AB - When mouse L cells are infected for 22 hr with vesicular stomatitis virus (VSV), a ribonucleic acid-containing enveloped virus, greater than 70% of the major histocompatibility antigen (H-2), is no longer detectable by the method of inhibition of immune cytolysis. Infected cells prelabeled with (14)C-glucosamine also show a correspondingly greater loss of trichloroacetic acid-insoluble radioactivity than uninfected cells. The loss of H-2 antigenic activity is not due to the viral inhibition of host cell protein synthesis since cells cultured for 18 hr in the presence of cycloheximide have the same amount of H-2 activity as untreated controls. Also, cells infected with encephalomyocarditis virus, a picornavirus, show no loss of H-2 activity at a time when host cell protein synthesis is completely inhibited. VSV structural proteins associated in vitro with uninfected L-cell plasma membranes do not render H-2 sites inaccessible to the assay. Although antibodies may not combine with all the H-2 antigenic sites on the plasma membrane, anti-H-2 serum reacted with L cells before infection does not prevent a normal infection with VSV. H-2 activity can be detected in virus samples purified from the medium of infected L cells; this virus purified after being mixed with L-cell homogenates shows greater H-2 activity than virus purified after being mixed with HeLa cell homogenates. However, VSV made in HeLa cells shows no H-2 activity when mixed with L-cell homogenates. PMID- 4343541 TI - Simian virus 40 deoxyribonucleic acid synthesis: the viral replicon. AB - Three temperature-sensitive (ts) mutants of simian virus 40 (SV40) in complementation group A (tsA7, tsA28, tsA30) have been isolated and characterized in permissive and restrictive host cells. At 41 C in the AH line of African green monkey kidney cells, the mutants are deficient in an early function required to produce infectious viral deoxyribonucleic acid (DNA). Temperature-shift experiments and analysis of SV40 viral DNA replication by gel electrophoresis have provided strong evidence that the ts gene product of the three mutants is directly required to initiate each new round of viral DNA replication but is not required to complete a cycle which has already begun. The synthesis of mutant DNA molecules themselves can be initiated by a nonmutant gene product in viral complementation studies at 41 C. The cell, however, cannot substitute a host function to provide the initiator required for the replication of free viral DNA. The viral initiator is also required to establish the stable transformation of 3T3 cells. PMID- 4343542 TI - Simian virus 40 deoxyribonucleic acid synthesis: analysis by gel electrophoresis. AB - An agarose-gel electrophoresis technique has been developed to study simian virus 40 deoxyribonucleic acid (DNA) synthesis. Superhelical DNA I, relaxed DNA II, and replicative intermediate (RI) molecules were clearly resolved from one another for analytical purposes. Moreover, the RI molecules could be identified as early or late forms on the basis of their electrophoretic migration in relation to that of DNA II. The technique has been utilized to study the kinetics of simian virus 40 DNA synthesis in pulse and in pulse-chase experiments. The average time required to complete the replication of prelabeled RI molecules and to convert them into DNA I was approximately 10 min under the experimental conditions employed. PMID- 4343543 TI - Mutant of vesicular stomatitis virus which allows deoxyribonucleic acid synthesis and division in cells synthesizing viral ribonucleic acid. AB - Some temperature-sensitive mutants of vesicular stomatitis virus were tested for their ability to block the initiation of deoxyribonucleic acid (DNA) synthesis and division in serum-stimulated hamster embryo fibroblasts at the nonpermissive temperature. Although the parental strain blocked these processes, one particular mutant allowed essentially normal DNA synthesis and division. By autoradiography, it was shown that individual cells infected with this mutant could synthesize viral ribonucleic acid and at the same time initiate DNA synthesis and divide. Cells infected with such conditional defective mutants appear to be suitable for studies on the effects of persistent viral infections on molecular and cellular functions in proliferating cell populations. PMID- 4343544 TI - Control of interferon synthesis: effect of diethylaminoethyl-dextran on induction by polyinosinic-polycytidylic acid. AB - Interferon production in cultures of rabbit kidney cells (RKC) stimulated with 10 to 250 mug of polyinosinic-polycytidylic acid (poly I.poly C) per ml peaked at 3 to 4 hr after the exposure of cells to inducer and rapidly declined thereafter. On the other hand, RKC stimulated with poly I.poly C (10 or 2 mug/ml) in the presence of diethylaminoethyl (DEAE)-dextran (100 or 20 mug/ml, respectively) produced a protracted interferon response, with the release of interferon continuing for over 24 hr. The kinetics of interferon production in RKC stimulated with lower concentrations of the mixture of poly I.poly C and DEAE dextran were similar to the response produced by poly I.poly C alone (10 to 250 mug/ml). Only the responses that terminated early were paradoxically enhanced by treatment with low doses of actinomycin D or with cycloheximide. Cells stimulated with 50 mug of poly I.poly C/ml showed hyporesponsiveness to a second interferon induction with poly I.poly C when restimulated 7 hr after primary induction. This hyporesponsiveness could be overcome by restimulating with higher concentrations of the poly I.poly C-DEAE-dextran complex. The results are compatible with the hypothesis that the early termination of interferon production and hyporesponsiveness to repeated induction with poly I.poly C are due to a cellular repressor exerting negative control on interferon synthesis, and that the increased cellular uptake of poly I.poly C in the presence of DEAE-dextran may effectively neutralize the repressor. These results also suggested that the often observed different kinetics and the varied effects of inhibitors of ribonucleic acid or protein synthesis on interferon responses in various cells and in cells stimulated with different inducers (such as with viruses as compared with polynucleotides) need not imply the existence of fundamentally different mechanisms of interferon production. PMID- 4343545 TI - Transcription of the herpes simplex virus genome in human cells. AB - We have examined the details of the transcription of the herpes simplex virus (HSV) genome in HeLa cells using deoxyribonucleic acid-ribonucleic acid (DNA-RNA) hybridization. The following findings are reported. (i) Virus-specific RNA (vRNA) synthesized following onset of HSV-DNA replication (L-vRNA) is complementary to as much as 90% of the HSV genome. (ii) There is no significant class of virus specific RNA synthesized later than L-vRNA. (iii) The vRNA synthesized prior to HSV-DNA replication (E-vRNA) is composed of two classes; one class comprising 75% of the total E-vRNA is found in large amounts as early as 45 min after infection, whereas the other class making up the other 25% of E-vRNA is found in only small amounts at 1.5 hr after infection. This second class of E-vRNA is found in amounts comparable to the first by 3.5 hr after infection. (iv) Inhibition of HSV DNA synthesis results in the continued synthesis of E-vRNA, but there is no synthesis of L-vRNA. (v) Finally, there is no class of vRNA found in the nucleus that is not found associated with cytoplasmic polyribosomes either early or late after infection. PMID- 4343546 TI - Adenylate-rich sequences in vesicular stomatitis virus messenger ribonucleic acid. AB - Vesicular stomatitis virus (VSV)-specific messenger ribonucleic acid (mRNA) species contain sequences of adenylate-rich RNA which are more heterogeneous in their migration through sodium dodecyl sulfate-polyacrylamide gels than the corresponding fractions from HeLa cell mRNA. VSV virion RNA contains no adenylaterich sequences. The possible role of such sequences in the mRNA species of a cytoplasmically replicating virus is discussed. PMID- 4343547 TI - Recovery of cell-bound interferon. AB - Interferon could be recovered from homologous cells to which it was applied but could not be recovered from heterologous cells. The amount of interferon that could be recovered from cells corresponded to the sensitivity of the cells to the antiviral activity of the interferon: mouse embryo fibroblasts, which were 5 to 10 times as sensitive as L-929 cells to interferon, bound 5 to 10 times more interferon than the latter, whereas Lpa cells, which were only one-third as sensitive as L-929 cells to interferon, bound only one-third as much as the latter. The concentration of cell-bound interferon was as much as 150 times the extracellular concentration of interferon applied to the cells. Interferon bound to cells at 4 C with the same efficiency as it did to cells at 37 C, and actinomycin D-treated cells bound interferon as well as normal cells. Even though the total amount of interferon bound to cells was as much as 30% of the amount of interferon applied to them, no loss of antiviral activity was detectable from the medium. PMID- 4343548 TI - Deoxyribonucleic acid repair in bacteriophage T4: observations on the roles of the x and v genes and of host factors. AB - Studies were carried out to determine the effect of mutation in the host pol I gene on survival of ultraviolet (UV)-irradiated bacteriophage T4. Whereas a slightly reduced survival was observed in Escherichia coli strain P-3478 (pol A(1)) compared to strain W-3110 (pol A(+)), no such difference was observed in two strains isogenic except for the pol A gene. It was also shown that, whereas bacteriophage T4x is sensitive to UV irradiation, X irradiation, and treatment with methyl-methanesulfonate (MMS), phage T4v(1) is sensitive only to UV irradiation. The survival of damaged phage T4x is neither affected by the presence of the rec A, rec B, or pol A mutations in the host, nor is there evidence that phage T4 effects repair of rec A or pol A mutants previously treated with either UV or MMS. PMID- 4343549 TI - Cleavage of viral precursor proteins in vivo and in vitro. AB - The use of protease inhibitors causes the accumulation of very large polypeptides (polyprotein) in tissue culture cells infected with either poliovirus or echovirus 12. The effectiveness of the inhibitor varies, depending on the cell line chosen. In infected monkey kidney cells, polyprotein is not cleaved when a chymotrypsin inhibitor is added, but in infected HeLa cells a trypsin inhibitor is most effective. Therefore, at least a part of the proteolytic activity is supplied by the host cell. Extracted viral polyprotein can be cleaved in vitro by trypsin or chymotrypsin. As estimated by migration in sodium dodecyl sulfate gels and antigenicity, chymotrypsin cleavage of the poliovirus polyprotein yields fragments which are similar to the in vivo product. The polyprotein is not in soluble form but is attached to a fast-sedimenting, membrane-bound structure. Proteolytic activities in cell extracts were assayed using polyprotein as substrate, and infected and uninfected extracts produced qualitatively dissimilar cleavages. PMID- 4343551 TI - Inhibition of cleavage of large poliovirus-specific precursor proteins in infected HeLa cells by inhibitors of proteolytic enzymes. AB - Inhibitors of chymotrypsin interfere with the post-translational cleavage of large poliovirus-specific polypeptides in the molecular weight range of 100,000 to 250,000 in infected HeLa cells. PMID- 4343552 TI - [Effect of CaC03 on the phosphatase activity in a culture of Actinomyces sp., strain 5 (coelicolor group) producing exonuclease A5]. PMID- 4343554 TI - [Studies on the mechanism of action of local anesthetic agents. 3. Relations between solubility of lipids and biological effect in homologous local anesthetic agents]. PMID- 4343550 TI - Ribonucleic acid synthesis in cells infected with herpes simplex virus. VI. Polyadenylic acid sequences in viral messenger ribonucleic acid. AB - Evidence is presented by use of radiolabeling and pancreatic and T1 ribonuclease digestion that some of the ribonucleic acid specified by herpes simplex virus contains polyadenylic acid sequences. The polyadenylic sequences are not transcribed from viral DNA. PMID- 4343553 TI - Influence of disodium ethane-1-hydroxy-1,1-diphosphonate on vitamin D metabolism in rats. PMID- 4343555 TI - [Conjunctivitis and keratoconjunctivitis caused by adenovirus]. PMID- 4343556 TI - Pancreatic islet beta cell tumours. PMID- 4343558 TI - [Age changes in spinal cord cells]. PMID- 4343559 TI - [Lipid metabolism indices in endemic goiter]. PMID- 4343557 TI - Amino acid neurotransmitter candidates: sodium-dependent high-affinity uptake by unique synaptosomal fractions. AB - Glutamic and aspartic acids and glycine are accumulated by high-affinity uptake systems into synaptosomal preparations in central nervous tissue. Sodium is required by these high-affinity transports, but not by the low-affinity transports for these and other amino acids. The sodium-requiring amino acid uptake systems label unique synaptosomal fractions. Observations suggest that these amino acids serve specific synaptic functions, presumably as neurotransmitters. PMID- 4343560 TI - [Therapeutic effect of lipiodol in urogenital system diseases]. PMID- 4343561 TI - Cochlear physiology and hair cell population in a strain of the waltzing guinea pig. PMID- 4343562 TI - Uridine diphosphate glucuronic acid production and utilization in various tissues actively synthesizing glycosaminoglycans. AB - 1. UDP-glucose dehydrogenase has been partially purified from sheep nasal septum cartilage, neonatal rat skin and bovine corneal epithelium. 2. The pH profile, K(m) values for NAD(+) and UDP-glucose, activation energy and molecular weight have been determined for the enzyme from several of the tissues. 3. The sugar nucleotide concentrations in each of the tissues have been related to the spectrum of glycosaminoglycans produced by each tissue. 4. The presence of an allosteric UDP-xylose-binding site distinct from the active site(s) in sheep nasal septum UDP-glucose dehydrogenase has been demonstrated. 5. An active UDP glucuronic acid nucleotidase has been demonstrated in sheep nasal cartilage. 6. Tissue-space experiments have shown the cell water content of sheep nasal septum cartilage to be 14% of the wet weight. 7. Glucuronic acid 1-phosphate does not occur in measurable amounts in sheep nasal septum cartilage and no UDP-glucuronic acid pyrophosphorylase activity could be detected in this tissue. 8. The inhibition by UDP-xylose with respect to both substrates, UDP-glucose and NAD(+), has been examined, and shown to be allosteric. PMID- 4343563 TI - The adaptive behaviour of isoenzyme forms of rat liver alanine aminotransferases during development. AB - 1. The activities of the mitochondrial and cytosol isoenzyme forms of l-alanine glyoxylate and l-alanine-2-oxoglutarate aminotransferases were determined in rat liver during foetal and neonatal development. 2. The mitochondrial glyoxylate aminotransferase activity begins to develop in late-foetal liver, increases rapidly at birth to a peak during suckling and then decreases at weaning to the adult value. 3. The cytosol glyoxylate aminotransferase and the mitochondrial and cytosol 2-oxoglutarate aminotransferase activities first appear prenatally, increase further after birth and then rise to the adult values during weaning. 4. In foetal liver the mitochondrial glyoxylate aminotransferase and the cytosol 2 oxoglutarate aminotransferase activities are increased after injection in utero of glucagon, dibutyryl cyclic AMP (6-N,2'-O-dibutyryladenosine 3':5'-cyclic monophosphate) or thyroxine. The cytosol glyoxylate aminotransferase and the mitochondrial 2-oxoglutarate aminotransferase activities are increased after injection in utero of cortisol or thyroxine. 5. After birth the further normal increases in the mitochondrial and cytosol 2-oxoglutarate aminotransferase activities can be hastened by cortisol injection, whereas the increase in cytosol glyoxylate aminotransferase activity requires cortisol treatment together with the intragastric administration of casein. 6. The results are discussed with reference to the metabolic patterns and the changes in regulatory stimuli (hormonal and dietary) that occur during the period of development. PMID- 4343564 TI - Further characterization of the polymorphic forms of a human high density apolipoprotein, apoLP-Gln-I (apoA-I). PMID- 4343566 TI - Purification of human, dog and rabbit -fetoprotein by immunoadsorbents of sepharose coupled with anti-human -fetoprotein. PMID- 4343565 TI - Interaction of glycoprotein hormones with agarose-concanavalin A. PMID- 4343567 TI - Paramagnetic anisotropy measurements on a single crystal of deoxyhemoglobin. PMID- 4343568 TI - The effect of ascorbic acid on the synthesis of collagen precursor secreted by 3T6 mouse fibroblasts in culture. PMID- 4343569 TI - The haem-plane orientation in single crystals of the meso- and deuteromyoglobins. PMID- 4343570 TI - Iron binding proteins and infection. PMID- 4343571 TI - Control of pancreatic amylase release in vitro: effects of ions, cyclic AMP, and colchicine. AB - 1. The time course and concentration-response relationship of amylase release from pieces of guinea-pig pancreas in vitro in response to bethanechol and pancreozymin was determined.2. Removal of Ca(++) from the medium had no effect on basal amylase release but abolished the stimulating effect on release of bethanechol.3. Elevation of the concentration of Mg(++) in the medium increased basal amylase release and reduced the response to bethanechol.4. Elevation of the concentration of K(+) in the medium increased amylase release; this effect was blocked by a concentration of atropine which blocked also the response to bethanechol.5. Cyclic AMP, dibutyryl cyclic AMP and theophylline failed to stimulate amylase release. Pancreatic cyclic AMP concentrations were found not to be increased by bethanechol, pancreozymin or an elevated concentration of K(+) in the medium.6. Colchicine had no effect on basal amylase release or the response to bethanechol or pancreozymin.7. It is concluded that the coupling of stimulus to secretion involves ionic control but that neither cyclic AMP production nor microtubular mechanisms play a major role in controlling exocytosis in the pancreatic acinar cell. These findings are discussed in relation to the stimulus secretion coupling processes in other cells. PMID- 4343572 TI - Analysis of the mechanism of action of some ganglion-blocking drugs in the rabbit superior cervical ganglion. AB - 1. Mechanisms of action of hexamethonium, mecamylamine and (+)-tubocurarine on the rabbit superior cervical ganglion were investigated by intracellular recording techniques.2. In concentrations up to 1 mM, none of these drugs affected the resting membrane potential nor altered the excitability of the postganglionic neurone to direct or antidromic stimulation.3. Post-tetanic potentiation of the excitatory postsynaptic potential (e.p.s.p.) was inhibited by mecamylamine (10-100 muM) but not affected by either hexamethonium (5-100 muM) or (+)-tubocurarine (10-50 muM).4. The decline in amplitude of successive e.p.s.ps in a train (40 Hz) was not influenced by hexamethonium or (+)-tubocurarine but was greatly exaggerated in the presence of mecamylamine; desensitization of the receptors for acetylcholine was excluded as a possible explanation for this latter finding.5. Mecamylamine depressed the quantal content of e.p.s.ps in a train, with the exception of the first e.p.s.p. which had an increased quantal content.6. Reduction in quantal content was attributed to a substantial fall in the size of the store of quanta of transmitter immediately available for release and to a reduction in the rate of mobilization of acetylcholine into that store; mecamylamine also caused a simultaneous increase in the fractional release.7. Hexamethonium and (+)-tubocurarine had no effect on transmitter release.8. The time-course of presynaptic effects of mecamylamine was similar to the duration of its postsynaptic blocking action.9. It is concluded that inhibition of ganglionic transmission by mecamylamine is due to both presynaptic and postsynaptic inhibitory actions; in contrast, hexamethonium and (+)-tubocurarine reduce transmission solely by their postsynaptic actions. PMID- 4343573 TI - The rat isolated colon as a specific assay organ for angiotensin. AB - 1. The antagonism of the contractile effects of prostaglandins F(2alpha) and E(2) by polyphloretin phosphate (PPP) was studied on the rat isolated colon.2. PPP (20 mug/ml) was found to reduce the myotropic action of angiotensin I (10 ng/ml) and II (0.3 ng/ml) whereas larger doses of both agents were not influenced.3. It is concluded that when a mixture of antagonists is used, including PPP, the rat isolated colon can be used to assay angiotensin with accuracy and specificity. The addition of 8-L-ala-AT(II) affords a further test of specificity. PMID- 4343574 TI - Inhibition of mitochondrial electron transport by guthion, some related insecticides, and degradative products. PMID- 4343576 TI - Renal vascular responses to angiotensin and norepinephrine in normal man. Effect of sodium intake. PMID- 4343575 TI - Renin, angiotensin II, and adrenal corticosteroid relationships during sodium deprivation and angiotensin infusion in normotensive and hypertensive man. PMID- 4343577 TI - Sodium intake and vascular smooth muscle responsiveness to norepinephrine and angiotensin in the rabbit. PMID- 4343578 TI - Amino acid incorporating activity of cell-free preparations from chicken liver and the factors that control the process. PMID- 4343579 TI - [Localization and possible physiological role of polyphosphate depolymerases in Neurospora crassa cells]. PMID- 4343580 TI - [Investigations of the problem of sleep status during experimental shift work]. PMID- 4343581 TI - An electron-microscope study of intracerebral infection of mice with low virulence Bordetella pertussis. PMID- 4343582 TI - Some tumours of the rat brain. PMID- 4343583 TI - Studies of elastic tissue in human breast lesions. PMID- 4343584 TI - Acute respiratory disease: clinical and epidemiologic observations of military trainees. PMID- 4343585 TI - A new technique for using spermatia in the production of mutants in Podospora. PMID- 4343586 TI - Estimating the frequency of induced dominant lethals in mice by uterine dissection after weaning progeny. PMID- 4343587 TI - Problems and potentials for human viral cancer vaccines. PMID- 4343588 TI - Some aspects of sleep in man. PMID- 4343589 TI - Sleep in the larger domesticated animals. PMID- 4343590 TI - Fanconi's anaemia: recent advances in diagnosis and treatment. PMID- 4343591 TI - Long-term ACTH treatment: an investigation. PMID- 4343592 TI - Neurological complications of haemodialysis. PMID- 4343593 TI - Calcium and the nervous system. PMID- 4343594 TI - Alcoholism 1971. PMID- 4343595 TI - [Therapeutic use of brain irritation with weak impulse electric current (brain electrotherapy) in medicine with exception of surgery]. PMID- 4343596 TI - Comparison of the binding of 7,12-dimethylbenz(a)anthracene and estradiol-17 in the calf uterus cytosol. PMID- 4343597 TI - [Radiotherapy of salivary gland neoplasms]. PMID- 4343598 TI - The mechanism of action of the radiosensitizing substance synkavit: ESR studies. PMID- 4343600 TI - [Concentrically layered nuclear inclusions in the kidney epithelium of chicken]. PMID- 4343599 TI - [Malignant mixed tumor of the gallbladder]. PMID- 4343601 TI - [Comparative study on the silicium content of mediastinal and cervical lymph nodes]. PMID- 4343602 TI - [Mastion. II. Pathological anatomy with special reference to covering connective tissue]. PMID- 4343603 TI - [Microscopic lung chemodectomas]. PMID- 4343604 TI - Determination of phosphate, silicate, and sulfate in natural and waste water by atomic absorption inhibition titration. PMID- 4343605 TI - Free radical assay technique for drugs (application to opiate analysis). PMID- 4343606 TI - Anaphylactic shock and corticotropin. PMID- 4343607 TI - [In vitro glycogenolysis and glycolysis in the tissues of normal rabbits or those treated with cortisone]. PMID- 4343609 TI - [Carcinoma of the female breast. Morphological aspects]. PMID- 4343608 TI - [Penetration of canavanine in different types of cells]. PMID- 4343610 TI - [Mammary carcinoma. Paths of dissemination, regional and distant--metastases]. PMID- 4343611 TI - [Carcinoma of the male breast. Morphological aspects]. PMID- 4343612 TI - Central adrenoceptors concerned in the release of adrenocorticotrophic hormone. AB - The effect of injecting the alpha-adrenoceptor stimulating drugs adrenaline, noradrenaline and phenylephrine and the beta-adrenoceptor stimulating drug, isoprenaline into the lateral ventricles (i.c.v.) of the brains of dogs on the plasma cortisol concentration was investigated. Adrenaline, noradrenaline and phenylephrine produced a significant rise in the plasma cortisol concentration. Isoprenaline had no effect on the plasma cortisol concentration. The effect of noradrenaline and phenylephrine on the plasma cortisol concentration was completely blocked by yohimbine (i.c.v.). This indicates that the stimulation of central alpha-adrenoceptors can cause the release of adrenocorticotrophic hormone. PMID- 4343613 TI - Glutamic acid mimicking of synaptic inhibition on the giant serotonin neurone of the snail. AB - Stimulation of the snail's tentacle nerves results in hyperpolarization and inhibition of the 'giant serotonin-containing neurone'located in the brain. Glutamic acid mimics this effect. Available data indicate that the reversal potential for the glutamic acid effect is very similar to that of the synaptic action being about 5 to 8 mV more negative than the resting potential in each case. PMID- 4343614 TI - Antibodies against membrane antigens of cytomegalovirus infected cells in sera of patients with a cytomegalovirus infection. PMID- 4343615 TI - Depression of delayed hypersensitivity by pretreatment with Freund-type adjuvants. 3. Depressed arrival of lymphoid cells at recently immunized lymph nodes in mice pretreated with adjuvants. PMID- 4343616 TI - Influence of 2,3-diphosphoglycerate on phosphofructokinase of human erythrocytes? PMID- 4343618 TI - The nature of electron transfer and energy coupling reactions. PMID- 4343617 TI - Factors affecting the concentration of 2,3-diphosphoglycerate in erythrocytes. PMID- 4343619 TI - Limitations of affinity chromatography: sepharose-bound cyclic 3',5'-adenosine monophosphate. PMID- 4343620 TI - Ethambutol-mediated alterations of the ESR of Cu(II)-polynucleotides complexes. PMID- 4343621 TI - Effects of thyroid hormones on phosphorylation of liver ribosomal proteins and on protein phosphokinase activity. PMID- 4343622 TI - Formation of a complex involving ADP-ribosylated human translocation factor, guanosine nucleotide and ribosomes. PMID- 4343623 TI - [Drug induced erythrocyte disorders]. PMID- 4343624 TI - A comparison of personality and success rates of drug addicts under two outpatient supervisory systems. PMID- 4343625 TI - The truthfulness of addict respondents in research projects. PMID- 4343626 TI - Collagenase activity of cariogenic streptococcus (Fa-1). Preliminary results. PMID- 4343627 TI - Pituitary and adrenocortical function of stress susceptible swine. PMID- 4343628 TI - The molecular organization of nerve membranes. VI. The separation of axolemma from Schwann cell membranes of giant and retinal squid axons by density gradient centrifugation. PMID- 4343629 TI - Actions of papaverine and bulbocapnine on synaptic transmission in the nigro striatal pathway in the rat. PMID- 4343630 TI - Birth and angiotensin II-like activity in lambs. PMID- 4343632 TI - Excitatory convergence on Renshaw cells. PMID- 4343631 TI - The outer disinhibitory surround of the retinal ganglion cell receptive field. AB - 1. There is an outer disinhibitory zone surrounding the classical inhibitory surround of the retinal ganglion cell receptive field.2. The disinhibitory surround is strong and narrow in ;sustained' cells but weak and laterally spread in ;transient' cells.3. The disinhibitory surround can be demonstrated using a black spot as a probing stimulus as well as by a white spot, and is therefore not an artifact of scattered light.4. Stimulation with a light spot in the disinhibitory zone gives an increase in firing to ;stimulus on' in on-centre cells and to ;stimulus off' in off-centre cells.5. The disinhibitory surround may be revealed by plotting the latency of the first spike discharge following stimulation against position in the receptive field. The disinhibitory zone shows a decrease in latency to the centre-type stimulus.6. The disinhibitory surround may be revealed by plotting the threshold intensity of a spot against position in the receptive field. It is thus a feature of the sensitivity gradients of both ;transient' and ;sustained' cells.7. Using two spots, one at the centre of the receptive field and the other at varying distances from the receptive field centre, dynamic interactions between the centre, inhibitory and disinhibitory zones are demonstrated. A spot presented in the disinhibitory zone causes an enhancement of the centre response when flashing in phase with the centre spot, while it causes inhibition of the centre response when presented 180 degrees out of phase.8. A scheme for the anatomical basis of the disinhibitory surround is proposed, and the relation of disinhibition to the spatial transfer characteristics of the visual pathways is discussed. PMID- 4343633 TI - The inhibition of hypoglossal motoneurones by glossopharyngeal nerve stimulation in the rat. PMID- 4343634 TI - The periphery effect and its relation to the receptive field organization of 'transient' retinal ganglion cells. PMID- 4343635 TI - Neuromuscular transmission in potassium-free Krebs solution. PMID- 4343636 TI - Amputee discussion program. PMID- 4343637 TI - An interactional approach to hospital visiting. PMID- 4343638 TI - A technique for facilitating therapeutic group interaction. PMID- 4343639 TI - Isolation and resistance in the elderly: a community mental health problem. PMID- 4343640 TI - Mental disorders in old age. PMID- 4343641 TI - shift in academic attitude and position? PMID- 4343643 TI - A pragmatic approach to group therapy. PMID- 4343642 TI - The psychiatric nurse therapist in private practice. PMID- 4343645 TI - Competitive protein binding assay of corticosterone. PMID- 4343644 TI - A simple procedure for the combined determination of plasma estrogen and androgen concentrations by competitive protein binding analysis. PMID- 4343646 TI - Virus surveillance in American military communities in Japan. I. Virus isolation studies. PMID- 4343647 TI - Peripheral nerve and root disturbances following active immunization against smallpox and tetanus. PMID- 4343648 TI - Structure and function of nitrogenase components in Azotobacter vinelandii. PMID- 4343649 TI - Maintenance adrenocorticotropic hormone (ACTH) treatment in myasthenia gravis. PMID- 4343650 TI - [Enzymatic and phagocytic activity of neutrophils in children with Down's syndrome]. PMID- 4343651 TI - [Neuropathogenic action of B. pertussis]. PMID- 4343652 TI - [Factors determining urinary excretion of cyclic 3',5' AMP]. PMID- 4343653 TI - [Phospholipids in skeletal muscles during muscle activity]. PMID- 4343654 TI - Field observations on the epidemiology of bovine herpes mammillitis. PMID- 4343655 TI - Cytological, cytogenetic and ultrastructural studies of rat cell lines carrying avian and murine sarcoma genomes. PMID- 4343656 TI - ["Membrane-encased" bodies in human thyroid gland]. PMID- 4343657 TI - Electron microscopic observations of the inner cell mass of a mouse embryo. PMID- 4343658 TI - Herpes simplex infection of the newborn. PMID- 4343659 TI - Parotitis and parainfluenza 3 virus. PMID- 4343660 TI - Analysis of the antigravitary tonic activity in the sleep-wakefulness cycle. PMID- 4343661 TI - Stimulation by calcium ions of pyruvate dehydrogenase phosphate phosphatase. PMID- 4343662 TI - Inositol lipid metabolism and cell membrane. PMID- 4343663 TI - The role of lipids in membrane structure. PMID- 4343665 TI - Biosynthesis of polymyxin, a peptide antibiotic. PMID- 4343664 TI - Peptides from a mycobacillin-synthesizing cell-free system. AB - In a cell-free system from Bacillus subtilis B(3), ATP-P(i) exchange was catalysed by l-proline at a pH optimum of 7.2. Further stimulation by component amino acids of mycobacillin was inhibited by deprivation from the synthesizing system of even a single amino acid occurring at any point of the cyclic peptide. This inhibition, however, decreased with the distance in the molecule of the given amino acid from l-proline. Peptides containing respectively two, three, four, five and six amino acids were isolated from the mycobacillin-synthesizing system by an amino acid-deprivation technique. The amino acid composition of these peptides and also their N- and C-terminal amino acid residues were the same as those of peptides that would be obtained if mycobacillin synthesis occurred starting from l-proline and was interrupted at various points along the polypeptide chain. PMID- 4343666 TI - Acyl phosphatase of Vigna catjang. PMID- 4343667 TI - Bull semen phosphodiesterase. PMID- 4343668 TI - Mechanism of regulation of the immune response. PMID- 4343669 TI - Preparation of Entamoeba histolytica antigen for column-chromatographic studies. PMID- 4343670 TI - Enzymic interaction between isoniazid and nicotinamide-adenine dinucleotide. PMID- 4343672 TI - The role of clearing-factor lipase in the removal of triglyceride fatty acids from the plasma. PMID- 4343673 TI - Millimeter wave EPR studies of some high spin myoglobin derivatives. PMID- 4343671 TI - The activities of fructose diphosphatase in flight muscles from the bumble-bee and the role of this enzyme in heat generation. AB - 1. The maximum catalytic activities of fructose diphosphatase from flight muscles of bumble-bees (Bombus spp.) are at least 30-fold those reported for the enzyme from other tissues. The maximum activity of fructose diphosphatase in the flight muscle of any particular bee is similar to that of phosphofructokinase in the same muscle, and the activity of hexokinase is similar to or greater than the activity of phosphofructokinase. There is no detectable activity of glucose 6 phosphatase and only a very low activity of glucose 6-phosphate dehydrogenase in these muscles. The activities of both fructose diphosphatase and phosphofructokinase vary inversely with the body weight of the bee, whereas that of hexokinase is relatively constant. 2. There is no significant hydrolysis of fructose 1-phosphate, fructose 6-phosphate, glucose 1,6-diphosphate and glycerol 3-phosphate by extracts of bumble-bee flight muscle. 3. Fructose 1,6 diphosphatase from bumble-bee flight muscle and from other muscles is inhibited by Mn(2+) and univalent cations; the potency of inhibition by the latter varies in the order Li(+)>Na(+)>K(+). However, the fructose diphosphatase from bumble bee flight muscle is different from the enzyme from other tissues in that it is not inhibited by AMP. 4. The contents of ATP, hexose monophosphates, fructose diphosphate and triose phosphates in bumble-bee flight muscle showed no significant changes between rest and flight. 5. It is proposed that both fructose diphosphatase and phosphofructokinase are simultaneously active and catalyse a cycle between fructose 6-phosphate and fructose diphosphate in resting bumble-bee flight muscle. Such a cycle would produce continuous hydrolysis of ATP, with the release of energy as heat, which would help to maintain the thoracic temperature during rest periods at a level adequate for flight. PMID- 4343674 TI - Metabolism of iodinated high density lipoprotein subunits in the rat. 3. Comparison of the removal rate of different subunits from the circulation. PMID- 4343675 TI - Ascorbate-dependent differences in the hydroxylation of proline and lysine in collagen synthesized by 3T6 fibroblasts in culture. PMID- 4343677 TI - Biological effects of Corynebacterium parvum. 3. Amplification of resistance and impairment of active immunity to murine tumours. AB - The effect of pre-treatment with Corynebacterium parvum on the growth in vivo of a range of experimental mouse tumours with differing characteristics has been investigated. Varying degrees of protection were observed which were generally greater with the more immunogenic tumours. Administration of C. parvum 7 days before immunization with irradiated tumour cells diminished the protective effect which could be obtained by immunization alone. The possible basis for these seemingly conflicting influences is considered. PMID- 4343678 TI - Anabolic steroids and bone marrow toxicity during therapy with methotrexate. AB - The effect of the anabolic steroids nandrolone decanoate and oxymetholone on the peripheral blood haemoglobin, total leucocyte and platelet counts was studied in a controlled trial in which patients received standardized chemotherapy for one form of malignant disease. The results indicate that these agents have no protective effect on bone marrow suppression during cytotoxic chemotherapy. It was observed that the time interval between the initial nadir total leucocyte count and the return to pre-treatment values in those patients receiving the anabolic steroids was significantly shorter than in the control group. PMID- 4343679 TI - Cytomegalovirus and EB virus infections of the liver. PMID- 4343680 TI - Antagonism between strychnine and glycine, and bicuculline and GABA, in the ventromedial hypothalamus. PMID- 4343681 TI - Post-stimulation changes of extracellular potassium concentration in the spinal cord of the rat. PMID- 4343676 TI - Foetal antigens and their role in the diagnosis and clinical management of human neoplasms: a review. PMID- 4343682 TI - Autoradiographic localization of the uptake of glycine in cultures of rat medulla oblongata. PMID- 4343683 TI - Penicillin and inhibition in the cat spinal cord. PMID- 4343685 TI - Cerebral pO 2 , pCO 2 and pH: changes during convulsive activity and their significance for spontaneous arrest of seizures. PMID- 4343684 TI - Hog spleen-phosphohydrolases-heterogeneity. PMID- 4343686 TI - [Lymphangiosis carcinomatosa of the lungs in the course of gelatinous carcinoma of the colon]. PMID- 4343688 TI - Diatomaceous earth for confused flour beetle and rice weevil control in rough, brown, and milled rice. PMID- 4343687 TI - Histochemical enzyme studies of sperms in a case of genuine necrospermia. PMID- 4343689 TI - Demonstration of antibody in cat sera to feline oncornavirus by complement fixation inhibition. PMID- 4343690 TI - Recent advances in multiple sclerosis. PMID- 4343691 TI - Acute viral encephalitis. PMID- 4343692 TI - [Clinical aspects of viral diseases of the respiratory system in calves]. PMID- 4343693 TI - Virus-related mental defect and disorder. PMID- 4343694 TI - Carcinogens in the nose and throat: nasopharyngeal carcinoma in Kenya. PMID- 4343695 TI - Management of some abnormalities of the chylous return. PMID- 4343696 TI - Genetic mapping of a murine leukemia virus-inducing locus of AKR mice. AB - The chromosomal location of one of the two murine leukemia virus-inducing loci of AKR mice has been determined. The locus, which appears to be the integrated genome of the virus, is designated Akv-1, and is on linkage group 1, 12 map units from Gpi-1, with gene order c-Gpi-1-Akv-1. This identification of a closely linked gene whose phenotype is independent of virus expression should facilitate analysis of the biologic importance of the Akv-1 locus. PMID- 4343697 TI - Location of the second gene required for expression of the leukemia-associated mouse antigens G IX . AB - Some mouse strains express G(IX) antigen on their thymocytes; others do not. Expression depends on two genes, Gv-1 and Gv-2, in linkage groups IX and I, respectively. Cells producing leukemia virus, however, express G(IX) antigen regardless of their inherited Gv-1 and Gv-2 genotype. PMID- 4343698 TI - Effect of colchicine, colcemid, and vinblastine on the agglutination, by concanavalin A, of transformed cells. AB - The sensitivity of transformed 3T3 fibroblasts to agglutination by concanavalin A is reduced by alkaloids that bind specifically to protein subunits of microtubules. PMID- 4343699 TI - Phosphorylase: a new isozyme in rat hepatic tumors and fetal liver. AB - A third set of phosphorylase a and b isozymes, distinguishable kinetically and immunologically from liver and muscle forms, is present in various rat hepatomas, and is also present, together with the adult liver form, in fetal rat liver. This is one of several striking examples of suppression of isozymes of adult liver coupled with the appearance of fetal isozymes in hepatomas. PMID- 4343700 TI - Synaptic transmission at single glomeruli in the turtle cerebellum. AB - We have recorded from the granular layer of the turtle cerebellum extracellular unitary potentials that appear to reflect pre- and postsynaptic events at the synapse between a single swelling of a mossy fiber and the dendritic tips of several granule cells. The presynaptic component is an all-or-none potential. It can be directly activated by spinal stimulation and is unaltered by repetitive activity or by high concentrations of magnesium. The postsynaptic component is a graded potential. It follows the presynaptic component by approximately 1 millisecond and is depressed by repetitive activity and by high concentrations of magnesium. The recording of large potentials produced by the flow of postsynaptic current within a single glomerulus suggests powerful transmission. Electron micrographs demonstrate large cerebellar glomeruli in the turtle and a substantial accumulation of mitochondria in the dendritic tips of granule cells. PMID- 4343701 TI - Prognostic factors in surgical treatment of bronchogenic carcinoma. PMID- 4343703 TI - Adrenergic receptor response in hypothyroidism. An in vitro study on human adipose tissue and rabbit aorta. PMID- 4343702 TI - [Homeostatic aspects of hormonal regulation of carbohydrate metabolism]. PMID- 4343704 TI - [The mechanism of the metabolic action of hormones]. PMID- 4343705 TI - Serum growth hormone and growth activity in children and adolescents with present or past malnutrition. PMID- 4343706 TI - Rat pineal gland in tissue culture. Morphology and enzyme histochemistry. PMID- 4343707 TI - Beckwith-Wiedemann syndrome. Wilms' tumor, cardiac hamartoma, persistent visceromegaly, and glomeruloneogenesis in a 2-year-old boy. PMID- 4343708 TI - [Mucous breast cancer]. PMID- 4343709 TI - [State of the vessels and bronchi in pulmonary adenomatosis]. PMID- 4343710 TI - [Gold deposits in synovial tissue in rheumatoid arthritis following gold therapy]. PMID- 4343711 TI - [EPR spectra of radicals in gamma-irradiated acetamide and dimethylacetamide and phototransformations of radicals at 77 degrees K]. PMID- 4343712 TI - [Spin relaxation of stable 2,2,6,6-tetramethyl-4-hydroxypiperidine-1-hydroxyl radical interacting in solutions with porphyrin complexes VO(II), Fe(3), Ni(II), Cu(II) and hemoglobin]. PMID- 4343713 TI - [Hydrophobic iminoxyl radicals as uncouplers of photophosphorylation in chloroplasts]. PMID- 4343715 TI - Structural constraints of possible mechanisms of lactate dehydrogenase as shown by high resolution studies of the apoenzyme and a variety of enzyme complexes. PMID- 4343714 TI - Structural studies on heart muscle malate dehydrogenases. PMID- 4343716 TI - Some aspects of the structure of staphylococcal nuclease. I. Crystallographic studies. PMID- 4343717 TI - Some aspects of the structure of Staphylococcal nuclease. II. Studies in solution. PMID- 4343718 TI - Tentative sequential model for the unfolding and refolding of staphylococcal nuclease at high pH. PMID- 4343719 TI - The binding of a spin-labeled triphosphate to hemoglobin. PMID- 4343720 TI - Conformational changes upon reduction of cytochrome c. PMID- 4343721 TI - Pulsed NMR study of the structure of cytochrome c. PMID- 4343722 TI - Mapping active sites of phosphoryl-transferring enzymes by magnetic resonance methods. PMID- 4343723 TI - The entatic state. PMID- 4343724 TI - [2 cases of hepatoma with hypoglycemia]. PMID- 4343725 TI - [Long term study of insulin secretion in 3 cases of islet cell adenoma]. PMID- 4343726 TI - [Ultrastructural study of an islet cell adenoma; demonstration of insulinogenic bodies by electron microscopy]. PMID- 4343728 TI - [Corticofugal effects on the somatic afferentation of the monkey caudate nucleus]. PMID- 4343727 TI - [Effect of exogenous lipoperoxides in reducing the polyunsaturated fatty acid level in animal liver as a result of free-radical processes in biolipids]. PMID- 4343729 TI - Some effects of altitude on thyroid function. PMID- 4343730 TI - Cyclic AMP formation and thyroid secretion by incubated mouse thyroid lobes. PMID- 4343731 TI - Stimulation of adrenocorticotropin (ACTH) and growth hormone (GH) release by ouabain: relationship to calcium. PMID- 4343732 TI - [Preparative studies on microsomal ascorbate: ferricytochrome-b 5 -oxidoreductase (EC1.10.2.1)]. PMID- 4343733 TI - Insulin secretion during development: response of isolated pancreatic islets of fetal, newborn and adult rats to theophylline and arginine. PMID- 4343734 TI - The measurement of ATP in pancreatic islets by means of the luciferin-luciferase reaction. PMID- 4343735 TI - Acid amyloglucosidase and carbohydrate regulation. II. Acid amyloglucosidase activity in the endocrine pancreas. PMID- 4343736 TI - Studies on deoxyribonucleic acid synthesis in uteri of immature mouse. PMID- 4343737 TI - Adrenocortical responsiveness to physiological amounts of 1-24 ACTH. II. Effect of acute corticotrophin treatment in patients receiving prolonged glucocorticoid therapy. PMID- 4343738 TI - Calcium homeostasis in the normal and thyroidectomized bovine. PMID- 4343740 TI - Uterine cyclic AMP-H 3 after estradiol and-or propranolol. PMID- 4343739 TI - Inhibition by calcium of the cyclic AMP-mediated stimulation of thymic lympholblast proliferation by prostaglandin E . PMID- 4343741 TI - Modification of an infrared spectrophotometer to study nerve excitation. PMID- 4343742 TI - Giant cell tumor of tendon sheath--a case report. PMID- 4343743 TI - Microphysiological characterization of output channels and of impulse propagation from the sensorimotor cortex. Including through pyramidal tract collaterals to the center median nucleus of the cat and of the monkey. PMID- 4343744 TI - Activities in synaptic pathways between the motor cortex and ventrolateral thalamus underlying EEG spindle waves. PMID- 4343745 TI - Morphology of the retina of the sea-snake, Pelamis platurus. PMID- 4343746 TI - Variations in interferon production by lymphocytes from patients with chronic lymphatic leukaemia. AB - In a group of patients with chronic lymphatic leukaemia leucocyte cultures showed a diminished capacity to synthesize interferon when compared with controls. The leucocyte culture with the lowest capacity to synthesize interferon came from the patients with the highest peripheral blood lymphocyte counts and vice versa. These results are presented as indirect evidence that T lymphocytes are more competent producers of interferon than B lymphocytes. PMID- 4343747 TI - Congenital dilatation of the intrahepatic bile ducts with cholangiocarcinoma. AB - Intrahepatic cholangiocarcinomas were found at necropsy in two previously reported cases of congenital dilatation of the intrahepatic bile ducts. The nature of the developmental abnormality is discussed and compared with other forms of biliary dilatation. Slow-flowing bile for many years probably leads to cholangiocarcinoma. PMID- 4343748 TI - Immunocytology of cultured IgM-forming cells of mouse. I. Requirement of phagocytic cell factor for the growth of IgM-forming tumor cells in tissue culture. PMID- 4343749 TI - DEAE-dextran and polybrene cation enhancement and dextran sulfate anion inhibition of immune cytolysis. PMID- 4343750 TI - The release of amino acids from the hemisected spinal cord during stimulation. PMID- 4343751 TI - The effect of moderate and marked hypercapnia upon the energy state and upon the cytoplasmic NADH-NAD+ ratio of the rat brain. PMID- 4343752 TI - Catecholamine induced increase of cyclic adenosine 3',5'-monophosphate in rat brain in vivo. PMID- 4343753 TI - Differential responses of free and bound polysomes to inhibitors and neuroactive substances in vitro. PMID- 4343754 TI - Spinal subarachnoid injection of colchicine in rats. PMID- 4343755 TI - [Various humoral mechanisms of regulating the secretory function of the stomach in patients with gastric and duodenal ulcer]. PMID- 4343756 TI - Tetracosactrin in the treatment of rheumatic diseases. PMID- 4343757 TI - Cytochemistry of membrane-bound ATPase systems of cardiac muscle. PMID- 4343758 TI - Enzyme histochemistry of heart muscle in normal and pathologic conditions. PMID- 4343759 TI - Physiological and biochemical changes induced by long-term stimulation of fast muscle. PMID- 4343760 TI - [Comparative characteristics of the hyaluronidase activity of different strains of Entamoeba histolytics]. PMID- 4343761 TI - [Decomposition of promethazine (Prothazin), promethazin sulfoxide and 9.9 dioxopromethazin (Prothanon)]. PMID- 4343762 TI - Synaptic organization of the mammalian olfactory bulb. PMID- 4343763 TI - Influence of phenobarbital and diphenylhydantoin on vitamin D metabolism and calcium retention in rats. PMID- 4343764 TI - Adenosine 3',5'-monophosphate: regional differences in chick embryos at the head process stage. AB - The concentrations of adenosine 3',5'-monophosphate and adenosine triphosphate and the activity of phosphodiesterase were determined in different regions of chick embryos at the head process stage. Adenosine 3',5'-monophosphate, adenosine triphosphate, and phosphodiesterase were estimated to be higher in the mesoderm forming portions of the hypoblast than in portions that form neural structures from Hensen's node or the epiblast. PMID- 4343765 TI - Mitochondrial polyriboadenylate polymerase: relative lack of activity in hepatomas. AB - An enzyme that polymerizes adenylate residues from adenosine triphosphate was prepared from rat liver mitochondria and compared to similar preparations from the mitochondria of three hepatomas. Enzyme activity in the hepatomas was only 1 to 2 percent of that in normal liver. PMID- 4343766 TI - Gene therapy for human genetic disease? PMID- 4343767 TI - Clinical correlates of the electrophysiologic action of digitalis on the heart. PMID- 4343768 TI - [Hypophysiotropic hormones of the hypothalamus]. PMID- 4343769 TI - [ACTH determination and its clinical application]. PMID- 4343770 TI - [Adrenocortical insufficiency due to therapy with corticosteroids]. PMID- 4343771 TI - [Diagnosis and treatment of islet-cell adenomas]. PMID- 4343772 TI - [Cytomegalovirus of green monkeys. Characteristics of its cytopathic effect]. PMID- 4343773 TI - [Anti-interfering effect of adenoviruses]. PMID- 4343774 TI - [Effect of serum antiviral inhibitors on resistance to influenza and acute respiratory diseases]. PMID- 4343775 TI - [Serological study of the role of Mycoplasma pneumoniae and respiratory viruses in the etiology of exacerbations of chronic pneumonias]. PMID- 4343776 TI - [Role of Sendai virus nucleocapsid in transcription of viral RNA]. PMID- 4343777 TI - [Use of 2-phase water-polymeric system for concentration of respiratory viruses in human nasopharyngeal swabs]. PMID- 4343778 TI - [Use of the immunofluorescent method for diagnosing acute respiratory infections]. PMID- 4343779 TI - [Rare causes of mechanical ileus of the small intestine]. PMID- 4343780 TI - Plasma renin activity, plasma renin substrate and urinary aldosterone excretion in the menstrual cycle in relation to the concentration of progesterone and oestrogens in the plasma. PMID- 4343781 TI - Gonadotrophins, testosterone and oestrogen levels in relation to ovarian morphology in 11 -hydroxylase deficiency. PMID- 4343782 TI - The source of circulating progesterone and 17 -hydroxyprogesterone in hydatidiform mole. PMID- 4343783 TI - Sonar and its use in kidney disease in children. PMID- 4343784 TI - Nephrogenic diabetes insipidus. Effects of 3,5, cyclic-adenosine monophosphate. PMID- 4343785 TI - Serum lipids and lipoproteins in children from families with early coronary heart disease. PMID- 4343786 TI - Purpura necrotica as a complication of ventriculoatrial shunts in hydrocephalus. PMID- 4343787 TI - Histiocytoma presenting as swelling on the toe. PMID- 4343788 TI - [Intracytoplasmic undulating tubules in human lymph nodes]. PMID- 4343789 TI - Circular dichroism study of the effects of magnesium perchlorate and temperature on the solution conformation of uridine 5'-monophosphate, uridine 3' monophosphate, uridine, and uridylyl-(3' leads to 5')-uridine. PMID- 4343790 TI - Determination of the secondary structures of proteins by circular dichroism and optical rotatory dispersion. PMID- 4343791 TI - Estrogen-binding proteins of calf uterus. Interrelationship between various forms and identification of a receptor-transforming factor. PMID- 4343792 TI - [Primary structure of transfer RNA]. PMID- 4343793 TI - Expression of differentiated functions in hepatoma cell hybrids. VI. Extinction and re-expression of liver alcohol dehydrogenase. PMID- 4343794 TI - [Specificity of thyroid hormones and growth hormone on the properties and protein biosynthesis of subcellular particles. I. Thyroidectomized rats]. PMID- 4343795 TI - Cancer of the colon in patients with ulcerative colitis since childhood. PMID- 4343796 TI - The proteinase and peptidase activities of certain components of the medium used in the in vitro tissue culture of bone. PMID- 4343797 TI - Intermittent closed suction-irrigation treatment of osteomyelitis. PMID- 4343798 TI - Clostridium pyoarthritis of the shoulder associated with multiple myeloma. PMID- 4343799 TI - Defective immunoreative insulin secretion in the Acomys cahirinus. PMID- 4343801 TI - [Specificity of neurochemical mechanisms of synaptic transmission of heterogenous excitations in the cerebral cortex]. PMID- 4343800 TI - Degradation of insulin and proinsulin by various organ homogenates of rat. PMID- 4343802 TI - [Isolation and properties of a molybdenum-containing peptide from component I of the nitrogen-fixing complex of Azotobacter vinelandii]. PMID- 4343803 TI - [Interrenal system of the sturgeon (Acipenser atellatus Pallas) and its functional relation with the hypophysis]. PMID- 4343805 TI - Stereospecificity of the dihydroorotate-dehydrogenase reaction. PMID- 4343804 TI - Enzyme regulation in neuroblastoma cells. Selection of clones with low acetylcholinesterase activity and the independent control of acetylcholinesterase and choline-O-acetyltransferase. PMID- 4343806 TI - A method for the rapid isolation of nuclear membranes from rat liver. Characterisation of the membrane preparation and its associated DNA polymerase. PMID- 4343807 TI - The covalent structure of collagen. Amino-acid sequence of peptide 1-CB6-C2. PMID- 4343809 TI - Study of the position of NAD and its effect on the conformation of D glyceraldehyde-3-phosphate dehydrogenase by small-angle x-ray scattering. PMID- 4343810 TI - A covalent protein-sepharose complex for the specific adsorption and assay of adenosine 3':5'-monophosphate. PMID- 4343808 TI - The covalent structure of collagen. The amino-acid sequence of the 112-residues. Amino-terminal part of peptide 1-CB6 from calf-skin collagen. PMID- 4343811 TI - [Phospholipid metabolism of nucleated red blood cells. Incorporation of 32 P orthophosphate into chicken plasma and globular phospholipids in vivo]. PMID- 4343812 TI - Antiviral activity of polynucleotides: role of the 2'-hydroxyl and a pyrimidine 5 methyl. PMID- 4343813 TI - The interaction of nucleotides with kinases, monitored by changes in protein fluorescence. PMID- 4343814 TI - On the influence of allosteric effectors on the electron paramagnetic spectrum of nitric oxide hemoglobin. PMID- 4343815 TI - Kinetic studies on the mechanism of the action of ADP on the glutamate dehydrogenase reaction. PMID- 4343816 TI - Cytochalasin B, pituitary metabolism, and the release of ox growth hormone in vitro. PMID- 4343817 TI - Formation of tetramer phosphorylase A in vivo. PMID- 4343818 TI - [Surgery for primary malignant brain tumors]. PMID- 4343819 TI - [Lobectomy in malignant tumors of the dominant hemisphere]. PMID- 4343820 TI - [Malignant nonfunctional islet cell tumor of the pancreas]. PMID- 4343821 TI - [Spasm in flexion disease in early childhood with typical and atypical symptomatology and its treatment. Apropos of 192 cases]. PMID- 4343822 TI - Effect of pyrrolnitrin on electron transport and oxidative phosphorylation in mitochondria isolated from Neurospora crassa. AB - Pyrrolnitrin, at low concentrations, uncouples oxidative phosphorylation in Neurospora mitochondria. At higher concentrations, pyrrolnitrin inhibits electron transport both in the flavine region and through cytochrome oxidase. PMID- 4343823 TI - Genetic studies on plasmid-linked cadmium resistance in Staphylococcus aureus. AB - The genetic basis of cadmium resistance conferred by three penicillinase plasmids, PI(524), PI(258), and PII(147), of Staphylococcus aureus was examined by mutation, recombination, and deletion analysis. Three separate loci were identified: cadA, responsible for high-level resistance; cadB, giving a low-level resistance, nonadditive to cadA; and mad, a locus marginally decreasing the cadmium resistance of plasmid-positive staphylococci. The loci cadA and mad were present on all three plasmids, but cadB was only found on PII(147). Spontaneous deletions of mad involved up to three-fourths of the plasmid genome, which allowed derivation of a partial deletion map of PII(147), a plasmid with a contour length of 10.9 mum, corresponding to a molecular weight of 20.4 x 10(6). PMID- 4343824 TI - Dominant mutations (lex) in Escherichia coli K-12 which affect radiation sensitivity and frequency of ultraviolet lght-induced mutations. AB - Three mutations, denoted lex-1, -2 and -3, which increase the sensitivity of Escherichia coli K-12 to ultraviolet light (UV) and ionizing radiation, have been found by three-factor transduction crosses to be closely linked to uvrA on the E. coli K-12 linkage map. Strains bearing these mutations do not appear to be defective in genetic recombination although in some conjugational crosses they may fail to produce a normal yield of genetic recombinants depending upon the time of mating and the marker selected. The mutagenic activity of UV is decreased in the mutant strains. After irradiation with UV, cultures of the strains degrade their deoxyribonucleic acid at a high rate, similar to recA(-) mutant strains. Stable lex(+)/lec(-) heterozygotes are found to have the mutant radiation sensitive phenotype of haploid lex(-) strains. PMID- 4343825 TI - Myxobacter AL-1 protease II: specific peptide bond cleavage on the amino side of lysine. AB - A second extracellular protease from myxobacter strain AL-1 has been purified to homogeneity and named protease II; the enzyme crystallizes as fine needles. The extracellular, cell wall lytic protease reported previously from the same organism is now designated protease I. Protease II exhibits a pH optimum of 8.5 to 9.0 and is stable from pH 3.0 to 9.0. The enzyme is heat stable at 50 C for 18 hr. Results of sedimentation equilibrium studies yielded a molecular weight of 17,000, and amino acid analysis revealed 157 residues with a minimal molecular weight of 16,660. Cleavage of peptide bonds in the oxidized B-chain of insulin, cytochrome c (horse heart). lysozyme, and vasopressin is restricted to the amino side of lysine. Dilysine and trilysine were not hydrolyzed. Products from digestions of polylysine were lysine and dilysine. PMID- 4343827 TI - The nature of the inhibition and activation of epidermal phosphofructokinase: an allosteric enzyme. PMID- 4343826 TI - Spontaneous auxotrophic and pigmented mutants occurring at high frequency in Bacillus pumilus NRRL B-3275. AB - Broth cultures of Bacillus pumilus NRRL B-3275 (BpB1) grown at 25, 30, or 37 C contain 1 to 2% spontaneous auxotrophic mutants in both the exponential and stationary phases of growth. Of 70 such mutants isolated from cultures grown at 37 C, approximately two-thirds reverted at such a high frequency as to preclude their study. Of the remaining 22 mutants, 18 required a single amino acid, 1 required adenine, and 1 required uracil. Two of the auxotrophs each required two unrelated amino acids resulting from two independent mutations. All of the mutations reverted spontaneously. Enhanced reversion of approximately one-third of the mutations was obtained with nitrosoguanidine, ethyl methane sulfonate, or diethyl sulfate, or with more than one of these mutagens. The reversion of one mutation was enhanced by 2-aminopurine. The reversion of the remaining mutations was not enhanced by the above mutagens, nor by mutagens known to induce (and revert) frameshift mutations in other bacterial systems. Nine of 10 mutants examined did not show a selective growth advantage over the parents. All but three of the mutations could be linked by PBS1 transduction to one of the previously described auxotrophic markers in strain BpB1. No evidence was obtained for clustering of the mutations on the BpB1 genome. Six of the mutations conferred a requirement for serine. One linked by transduction to trp-2, three linked to argA1, and two (ser-2, -3) linked to argO1. Pigmented mutants (containing a carotenoid-like pigment), which occur spontaneously in BpB1 cultures at a frequency on the order of 1 to 5 mutants per 10(4) cells, link by transduction to ser-2, -3. Spontaneous mutants of strain BpB1 resistant to rifampin, streptomycin, erythromycin, 5-fluorouracil, or 5-methyltryptophan occur at a frequency similar to that of strains of B. pumilus which do not exhibit a high rate of spontaneous mutation to auxotrophy. It is suggested that certain sites or regions of the BpB1 genome exhibit a high rate of spontaneous mutation. PMID- 4343828 TI - Primary liver carcinoma with hyperlipidemia. Report of two cases. PMID- 4343829 TI - Structured bienzymatical models formed by sequential enzymes bound into artificial supports: active glucose transport effect. PMID- 4343830 TI - Collagenolytic activity in keratocysts. PMID- 4343831 TI - Cytocentrifugation in the management of central nervous system leukemia. PMID- 4343832 TI - Mechanism of the action of products of reactions of formaldehyde with nucleotides (methylene dinucleotides) on the cell and virus reproduction. PMID- 4343834 TI - Catabolic repression in isolated mitochondria. PMID- 4343835 TI - Reaction of plant ferredoxin with nitric oxide. PMID- 4343833 TI - Differentiated change in polyribosome and free ribosome density with an increase in ionic strength. PMID- 4343836 TI - An investigation of the microrelief and conformational mobility of proteins by the ESR method. PMID- 4343837 TI - The acceptor activity of dissected molecules of Baker's yeast tRNA Val 1 : localization of two possible recognition sites of valyl-tRNA ligase. PMID- 4343839 TI - [Contribution of the electrophysiological study of reflexes in the exploration of motoricity disorders]. PMID- 4343838 TI - [Results of combined administration of anabolis steroids in patients with multiple sclerosis]. PMID- 4343840 TI - Economical use of hospital beds. PMID- 4343841 TI - [Characteristics of the elastolytic complex from Actinomyces rimosus- rimoprotelin]. PMID- 4343842 TI - [Purification of protamine sulfate and its use to isolate acid and base proteins and nucleic acids]. PMID- 4343843 TI - Cardiomyopathies in infants and children. PMID- 4343844 TI - Type C virus from cell cultures of chemically induced rat hepatomas. AB - Type C RNA viruses are present in cell cultures from transplantable and primary hepatomas induced by aromatic amine carcinogens. Virus yield was markedly enhanced by treating the cells with bromodeoxyuridine. Preparations of rat hepatoma-associated virus obtained from cultures treated with this compound were deficient in DNA polymerase activity. PMID- 4343845 TI - Summated cortical evoked response testing in the deafferented primate. AB - Dorsal rhizotomy from C(2) or C(3) to T(4) in the primate results in failure to elicit summated cortical responses from systematic stimulation of the appropriate peripheral nerves. Under these conditions there is thus no evidence of sensory input into the cerebral cortex. A nonclassical mechanism must therefore be operational to explain the extensive purposive movements observed in the deafferented animals. PMID- 4343846 TI - Ultrastructural observations on chemically induced inflammation in guinea pig trachea. PMID- 4343847 TI - Histochemical demonstration of acid mucopolysaccharides in Sanfilippo's disease: an ultrastructural study of the liver. PMID- 4343848 TI - [Lipid deposits in the aortal intima of cholesterol fed rabbits as seen by freeze etching]. PMID- 4343849 TI - [Non-specific resistance to the toxic effects of viruses]. PMID- 4343850 TI - [The influence of heparin on the interferonogenicity and interference induced by a virus or a synthetic polynucleotide]. PMID- 4343851 TI - [Tumor induction in mice by Rous sarcoma virus]. PMID- 4343853 TI - Subsurface cisterns and lamellar bodies: particular forms of the endoplasmic reticulum in the neurons. PMID- 4343852 TI - An ultrastructural study of a cytoplasmic filamentous body, termed nematosome, in the neurons of the rat and cat substantia nigra. The association of nematosomes with the other cytoplasmic organelles in the neuron. PMID- 4343854 TI - [Immunofluorescent localisation of corticotrophic and melanotrophic hormones in the pituitary gland of the rodent Ellobius lutescens (Th)]. PMID- 4343855 TI - The effect of dehydration on the ultrastructure and cholinesterase activity of the subcommissural organ in the rat. PMID- 4343856 TI - The fine structure of the retinula of the compound eye of Astacus fluviatilis. PMID- 4343857 TI - Electron microscopic studies on the pars intermedia in normal and in mice with hereditary nephrogenic diabetes insipidus. PMID- 4343858 TI - [Histological and histochemical studies of the islands of Langerhans and exocrine pancreas tissue of rats before and after truncular vagotomy]. PMID- 4343859 TI - Histoenzymology of experimental cyanide encephalopathy. PMID- 4343860 TI - Common viral diseases of childhood. PMID- 4343861 TI - Clues to the diagnosis of hyperlipoproteinemia. PMID- 4343862 TI - Spontaneous activity in visual systems. PMID- 4343863 TI - Polyelectrolyte flocculation as an aid to recovery of enteroviruses from oysters. AB - A simple and rapid method for recovering enteroviruses from oysters is described. A polycation sewage flocculant promoted cohesion of oyster solids and thereby aided separation of these from the viruses. Recovery of 80 to 100% of experimentally inoculated virus was achieved, and the suspension or extract obtained could be inoculated directly into tissue cultures or concentrated first for greater sensitivity. PMID- 4343864 TI - Bacterial degradation of detergent compounds. AB - A survey for surfactant degradation among aerobic bacteria has been undertaken. Tests have been made in peptone medium where such a degradation, if it occurs, will be gratuitous. Tallow-alkyl-sulfate, alkyl-ethoxylate-sulfate, and linear alkyl-benzene-sulfonate were used. Forty-five strains of 34 species in 19 genera degrade one or more of these detergent compounds. With some species, the surfactant inhibits degradation without inhibiting growth, whereas with one species slight degradation took place even at a toxic concentration of surfactant. PMID- 4343865 TI - Assessment of the sanitary effectiveness of holding temperatures on beef cooked at low temperature. AB - Beef cubes cooked at low temperature were surface inoculated and incubated at 43.3 through 53.3 C to establish temperature limits for growth of staphylococci, salmonellae, and Clostridium perfringens. A greater than 99% reduction in staphylococci was achieved after 6 hr at 48.8 C, of salmonellae at 51.1 C, and of C. perfringens at 53.3 C. There were no survivors of a mixed inoculum of Staphylococcus aureus, Salmonella enteritidis, and C. perfringens after 12 hr at 51.1 C. PMID- 4343867 TI - Simultaneous oral administration of live adenovirus types 4 and 7 vaccines. Protection and lack of emergence of other types. PMID- 4343866 TI - Relative chlorine resistance of poliovirus I and coliphages f2 and T 2 in water. AB - Phage f2 is markedly more resistant to chlorine in water than either poliovirus or coliphage T(2). Its potential use as an indicator of viral pollution is suggested. PMID- 4343868 TI - [2,2 and 1,2-Bisaralkylmercapto- and -aralkylsulfonylpropanes]. PMID- 4343869 TI - Biosynthesis of respiratory tract mucins. 3. Metabolism of aminosugars by tracheal mucosal extracts. PMID- 4343870 TI - Kinetic studies of beef liver diacetyl reductase. PMID- 4343871 TI - Properties of glutaraldehyde-modified bovine hepatic fructose-1,6-diphosphatase. PMID- 4343872 TI - Cartilage collagen: inability to serve as a substrate for collagenases active against skin and bone collagen. PMID- 4343873 TI - [Polyoma virus mutants]. PMID- 4343874 TI - [Rous virus mutants]. PMID- 4343875 TI - [Repression and induction of SV 40 virus]. PMID- 4343876 TI - Asymmetrical activation by Ca2+ of the erythrocyte membrane K+ -dependent phosphatase. PMID- 4343878 TI - [Delineation of the ascendant pathway responsible for ponto-geniculo-occipital activity in the cat]. PMID- 4343877 TI - Pentobarbital-induced increase of rat liver phosphoprotein phosphatase. PMID- 4343879 TI - Antigenic variation of the avian myeloblastosis virus obtained from chick embryo fibroblasts. PMID- 4343880 TI - [Histochemical enzyme studies of the effect of calcitonin on the rat pineal body]. PMID- 4343881 TI - A model for investigating erythropoiesis. PMID- 4343883 TI - Shock in acute pancreatitis and hypovolaemia. PMID- 4343882 TI - Properties of hexokinase bound to glass. PMID- 4343884 TI - [Microbiological and experimental studies on Pseudomonas pyocyanea]. PMID- 4343885 TI - Release of thiols from cellular mixed disulphides and its possible role in radiation protection. PMID- 4343886 TI - Carcinoma of the lung: an improving surgical prognosis. PMID- 4343887 TI - Neurite development in vitro. I. The effects of adenosine 3'5'-cyclic monophosphate (cyclic AMP). PMID- 4343889 TI - Angiotensin I converting enzyme and kininase. PMID- 4343888 TI - Development of motility in fish embryos in relation to release from early CNS Inhibition. PMID- 4343891 TI - Interaction of angiotensin and noradrenaline in rat's hindlimb preparation. A possible mechanism of the experimental renal hypertension. PMID- 4343890 TI - Plasma angiotensin I converting enzyme activity in rabbits under various experimental conditions. PMID- 4343892 TI - Central action of angiotensin and hypertension--increased central vasomotor outflow by angiotensin. PMID- 4343893 TI - The mechanism of estrogen hypertension. PMID- 4343894 TI - [Measurement of plasma renin activity by angiotensin I radioimmunoassay--a modification of Haber's method]. PMID- 4343895 TI - [Demonstration of lipoproteins of high density (HDL) from the plasma with the aid of zonal centrifugation]. PMID- 4343896 TI - [Comparative studies on lipoprotein changes after cholestasis in rats and humans]. PMID- 4343897 TI - Herpes simplex virus infection of HEp-2 and L-929 cells. 3. Envelopment of virus particles and particle infectivity ratios. PMID- 4343898 TI - The genetic relationship of two canine adenoviruses as determined by nucleic acid hybridization. PMID- 4343899 TI - [The treatment of trichomoniasis in women]. PMID- 4343900 TI - [Virologic studies of intrauterine derived cytomegalovirus infections and its sequelae]. PMID- 4343901 TI - [A new method for the quantitative determination of morphine]. PMID- 4343902 TI - [Combined chemoradiation therapy of pulmonary cancer]. PMID- 4343903 TI - Osteosarcoma of the breast. PMID- 4343904 TI - [Ocular lesions caused by Entamoeba histolytica]. PMID- 4343905 TI - On the existence of receptors for estradiol in normal and malignant human tissue and the mode of action of progesterone. PMID- 4343906 TI - [Sensitivity of herpes simplex virus to antiviral and other several drugs]. PMID- 4343907 TI - Psychobiologic effects of prolonged weightlessness (bed rest) in young healthy volunteers. PMID- 4343908 TI - [Persistence and disinfection of foot-and-mouth disease (FMD) virus in liquid dung from manure washings]. PMID- 4343909 TI - [Synthesis of virus-specific proteins on heterologous and homologous ribosomes]. PMID- 4343910 TI - [Cytochrome composition of yellow lupin nodules]. PMID- 4343911 TI - [Distribution and localization of nucleoside phosphatases in rat liver endoplasmic reticulum membranes]. PMID- 4343912 TI - [Subcellular localization of rat cerebral cortical hexokinase]. PMID- 4343913 TI - [Effect of pentagastrin and histamine on adenyl cyclase activity in the rat stomach]. PMID- 4343914 TI - [Transformation of 3-methylpyridine to biologically active derivatives and its intracellular localization in rat liver]. PMID- 4343915 TI - [Structural components of plasma membranes of normal and neoplastic animal cells]. PMID- 4343916 TI - [Interaction of myoglobin with isocyanide spin label]. PMID- 4343917 TI - Spontaneous bioelectric activity of neurons in cerebellar cultures: evidence for synaptic interactions. PMID- 4343918 TI - The antagonistic action of glutamic acid diethylester towards amino acid-induced and synaptic excitations of central neurones. PMID- 4343919 TI - Neuronal activities in epileptogenic foci of immature cortex. PMID- 4343920 TI - [Study of upper limb abnormlities in the Slovak population. Preliminary report]. PMID- 4343922 TI - An actin-like component in spermatocytes of a crane fly (Nephrotoma suturalis Loew). II. The cell cortex. PMID- 4343923 TI - [Intracellular transcription of the genome of paramyxovirus within the nucleocapsid]. PMID- 4343921 TI - An actin-like component in spermatocytes of a crane fly (Nephrotoma suturalis Loew). I. The spindle. PMID- 4343924 TI - [Properties of virus-specific RNA in cells transformed by polyoma virus]. PMID- 4343925 TI - [Effect of 2-(alpha-hydroxybenzyl)-benzimidazole and guanidine on the activity of RNA polymerases, induced by encephalomyocarditis viruses and poliovirus]. PMID- 4343927 TI - Relation between anaerobic ATP synthesis from pyruvate and nitrogen fixation in Azotobacter vinelandii. PMID- 4343926 TI - [Blood pressure dynamics in the albino rat in combination with exteroreceptive stimulation factors and administration of angiotensin II]. PMID- 4343928 TI - Protein phosphokinases of chick muscle: changes during embryonic development. PMID- 4343929 TI - 13 C nuclear magnetic relaxation times and models for chain motion in lecithin vesicles. PMID- 4343930 TI - Effect of tryptophan modification on the activity of bacterial and viral neuraminidase. PMID- 4343931 TI - Proton-translocating pyrophosphatase of Rhodospirillum rubrum. PMID- 4343932 TI - Immunochemistry of the capsular polysaccharides from Clostridium perfringens: selected Hobbs strains 1, 5, 9, and 10. AB - The properties of the immunochemically distinct substances isolated from four strains of Clostridium perfringens, mucoid variants of Hobbs 1, 5, 9, and 10, were shown to be compatible with the hypothesis that polysaccharides are generally responsible for the "type-specificity" of these organisms. The presence of "group-specific" substance was demonstrated by the cross-reaction of recent preparations of Hobbs 5 antisera with the isolated polysaccharides. The cross reactions were not observed with specific antisera of the other strains studied and were independent of the "type-specific" phenomenon. PMID- 4343933 TI - Organ cultures of respiratory epithelium infected with rhinovirus or parainfluenza virus studied in a scanning electron microscope. AB - Organ cultures of bovine tracheal epithelium were infected with a rhinovirus or a strain of parainfluenza type 3 virus, and the epithelial surfaces were studied by scanning electron microscopy. When washed free from mucus, normal control cultures showed a thick carpet of normal cilia, whereas the two viruses each produced specific morphological abnormalities. In rhinovirus-infected cultures, degenerating ciliated and nonciliated cells with finely granular surfaces were rapidly extruded from the epithelium. The denuded epithelial surface was relatively smooth, and showed some evidence of squamous metaplasia. By contrast, in cultures infected with parainfluenza type 3 virus, damage developed more slowly and the epithelial surface was ultimately covered with a profuse array of short microvillous projections. In thin sections, some of these were shown to be the sites of viral maturation. PMID- 4343934 TI - Sensitization of mice by inhalation of antigen after infection with Bordetella pertussis. AB - Intranasal infection of mice with Bordetella pertussis or injection of pertussis vaccine previous to administration of an albumin aerosol augments sensitivity toward albumin. Sensitization was demonstrated by provocation of anaphylactic reactions following intravenous injection of antigen. PMID- 4343935 TI - Evaluation of urinary cyclic 3'5'-adenosine monophosphate excretion in the differential diagnosis of hypercalcemia. PMID- 4343936 TI - Competitive binding assay for adenosine 3',5'-monophosphate employing a bovine adrenal protein: application to urine, plasma and tissues. PMID- 4343937 TI - In vivo and in vitro production of human chorionic gonadotropin and alpha feteoprotein by a virilizing hepatoblastoma. PMID- 4343938 TI - Decreased urinary adenosine 3',5' monophosphate (cyclic AMP) in asthmatics. PMID- 4343940 TI - NAD kinase in human polymorphonuclear leukocytes. PMID- 4343941 TI - Diseases of zoo animals in Nigeria. PMID- 4343939 TI - Salt, water, and rest as a preventative for toxemia of pregnancy. A commentary and review. PMID- 4343942 TI - Myoclonic encephalopathy. ("Dancing eyes" syndrome with myoclonic ataxia). PMID- 4343944 TI - Medical research in the Federal services. PMID- 4343945 TI - Retransformation of ts SV40 transformants by murine sarcoma virus at non permissive temperature. PMID- 4343943 TI - The effect of dietary supplementation of cholesterol and its subsequent withdrawal on the liver lipids and serum lipoproteins of chickens. PMID- 4343946 TI - Synthesis of bacteriophage lambda proteins in vitro. PMID- 4343947 TI - Molecular basis of gouty inflammation: interaction of monosodium urate crystals with lysosomes and liposomes. PMID- 4343948 TI - Diurnal fluctuation and -adrenergic elevation of cyclic AMP in mouse epidermis in vivo. PMID- 4343949 TI - Effects of cyclic AMP on SV3T3 cells in culture. PMID- 4343950 TI - Cyclic AMP mediates the effects of adrenaline on cardiac purkinje fibres. PMID- 4343951 TI - Involvement of DNA in the acceptor mechanism for uterine oestradiol receptor. PMID- 4343952 TI - Syncytial assay for the putative human C-type virus, RD-114, utilizing human cells transformed by Rous sarcoma virus. PMID- 4343953 TI - Herpesvirus hominis specific antigen in cells of human malignant glioma. PMID- 4343954 TI - [Drug interactions with psychopharmacologic agents]. PMID- 4343955 TI - Bidirectional replication of Simian Virus 40 DNA. AB - SV40 (Simian Virus 40) DNA was pulse-labeled with [(3)H]thymidine in infected monkey cells, and the distribution of label within newly completed molecules was determined by analysis of specific fragments produced by restriction endonuclease from Hemophilus influenzae. From these data, an order of synthesis or temporal order of the fragments was deduced. Comparison of the temporal order with the physical order of the fragments in the SV40 DNA molecule indicates a correspondence in these orders for two separate groups of fragments. From an analysis of the results, we conclude that SV40 DNA replication begins at a specific site and proceeds bidirectionally, terminating about halfway around the circular molecule from the initiation point. PMID- 4343957 TI - Electron paramagnetic resonance of nitrogenase and nitrogenase components from Clostridium pasteurianum W5 and Azotobacter vinelandii OP. AB - The electron paramagnetic resonance of nitrogenase components, separately and together with the other reactants in the nitrogenase system (namely, reductant and Mg.ATP), have been examined at low temperatures (<20 degrees K). The MoFe protein, component I or molybdoferredoxin, in the oxidized (but not oxygen inactivated) state yields signals with g-values of 4.3, 3.7, and 2.01, and when reduced has no observable electron paramagnetic resonance. The Fe protein, component II, or azoferredoxin, yields a signal with g-values of 2.05, 1.94, and 1.89 in the reduced state that is converted by Mg.ATP into an axial signal with g values near 2.05 and 1.94, and a second split signal near g = 4.3. The Fe protein has no definite electron paramagnetic resonance in the oxidized (not oxygen denatured) state under these conditions. The Mg.ATP complex of reduced Fe protein reduces the MoFe protein, whereas dithionite alone does not reduce the MoFe protein. Reoxidation of the system by substrate leads to disappearance of the Fe protein signal and the reappearance of the MoFe protein signal. Thus Mg.ATP, which is hydrolyzed during substrate reduction, converts the Fe protein to a reductant capable of transferring electrons to MoFe protein, after which substrate reduction occurs. PMID- 4343956 TI - Glucocorticoid action on hybrid clones derived from cultured myeloma and lymphoma cell lines. AB - Cells of a cloned myeloma line from a Balb/c mouse contain specific cytoplasmic glucocorticoid receptors and are killed by dexamethasone. Cells of a lymphoma line (from mouse strain C57BL) also contain specific glucocorticoid receptors but are resistant to the steroid. Cells of two hybrid clones with widely differing chromosome numbers, derived by fusion between the resistant lymphoma and the sensitive myeloma, contain specific glucocorticoid receptors with similar binding properties as the parental receptors and are killed by dexamethasone. Since the lethal effect of the steroid is expressed in the hybrid cells, failure of the parent lymphoma line to be affected by dexamethasone is probably not due to an inhibitor of the lethal reaction. PMID- 4343959 TI - Specificity of the break produced by restricting endonuclease R 1 in Simian virus 40 DNA, as revealed by partial denaturation mapping. AB - Superhelical circular (form I) SV40 DNA was converted to linear molecules by the action of a partially purified restriction enzyme of Resistance Transfer Factor R(1) of Escherichia coli. The resulting linear DNA molecules are full length, as judged by their sedimentation through alkaline sucrose gradient and by direct observation in an electron microscope. Nicked circular (form II) DNA was found as an intermediate in the conversion of form I DNA to linear DNA. Analysis of partial denaturation maps obtained by alkaline denaturation of the unitlength linear molecules showed that the break in SV40 DNA occurred at a specific site on the DNA. PMID- 4343958 TI - Membrane site modified on induction of the transformation of lymphocytes by periodate. AB - Lymphocytes isolated from different sources undergo blastogenesis after mild treatment with periodate. Incubation of mouse spleen lymphocytes with neuraminidase or papain markedly reduces their response to periodate. Transformation induced by concanavalin A of the enzymically treated cells is not impaired. Blastogenesis induced by periodate is decreased when periodate-treated lymphocytes are reacted with borohydride, hydroxylamine, or semicarbazide. Treatment with these compounds does not affect transformation of cells by concanavalin A. It is suggested that different membrane sites are involved in lymphocyte transformation induced by periodate and by concanavalin A. The periodate target site seems to include a glycoprotein complex containing sialic acid that yields, on oxidation, an aldehyde moiety that is essential for transformation. PMID- 4343960 TI - Mixed conformations of deoxyribonucleic acid in chromatin: a preliminary report. AB - We have established empirical limits for the circular dichroism spectra appropriate for aqueous solutions of the B, C, and A forms of calf-thymus DNA and have analyzed DNA conformations in biological structures. The circular dichroism spectrum above 250 nm of purified calf-thymus chromatin can be satisfactorily accounted for as a linear combination of contributions of the B and C reference spectra without invoking higher-order structures such as supercoils. The amount of A contribution, if any, is below the limit of detection (100 nm and <220 nm. Iguana virus is ether-sensitive and, as presumptively indicated by studies of inhibition by bromodeoxyuridine, possesses a deoxyribonucleic type of nucleic acid. The virus characteristics described, as well as electron microscopy observations described in a separate report, indicate that iguana virus is a member of the herpesvirus group. PMID- 4344307 TI - Effect of 5-hydroxytryptophan (5-HTP) on growth hormone and ACTH release in man. PMID- 4344308 TI - Aldosterone secretory and glucocorticoid excretory responses to alpha 1-24 ACTH (Cortrosyn) in sodium-depleted normal man. PMID- 4344309 TI - The effect of Zn-tetracosactrin on growth hormone release during sleep. PMID- 4344310 TI - Exacerbation of Cushing's syndrome during pregnancy: report of a case. PMID- 4344311 TI - Effect of aerosolization on the transport of -methyl glucoside and galactosides into Escherichia coli. PMID- 4344312 TI - Studies on interferon induction by the avian adenovirus CELO in chicken cells. PMID- 4344313 TI - Virus-specific polypeptides in ascites cells infected with encephalomyocarditis virus. PMID- 4344314 TI - Effect of two rifamycin derivatives on the Rous sarcoma virus transformation system. PMID- 4344315 TI - Repair replication: a density-gradient analysis of DNA from cells infected with mengovirus or Newcastle disease virus. PMID- 4344316 TI - Assay of the infectivity of Epstein-Barr virus by transformation of human leucocytes in vitro. PMID- 4344318 TI - Neurogenic tumours of the head and neck. PMID- 4344317 TI - Recovery and characterization of non-cytopathogenic rhinoviruses. PMID- 4344319 TI - The ultrastructure of salivary gland tumors. PMID- 4344320 TI - Bell's palsy--a clinical survey. PMID- 4344321 TI - The modern management of Bell's palsy. PMID- 4344322 TI - Epidemiology of Hodgkin's disease. PMID- 4344323 TI - Surgical management of ophthalmopathy in Graves' disease. Transfrontal orbital decompression. PMID- 4344324 TI - Perspectives of psychiatric aftercare in the community. An effective rehabilitation program. PMID- 4344325 TI - The nature of the transfer inhibitor of several F-like plasmids. PMID- 4344326 TI - Prednisone treatment for idiopathic facial paralysis (Bell's palsy). PMID- 4344327 TI - Effects of the renin inhibitor pepstatin on the blood pressure of intact and nephrectomized rats. PMID- 4344328 TI - Influence of extracellular noradrenaline on the stimulation-evoked secretion of noradrenaline from sympathetic nerves: evidence for an -receptor-mediated feed back inhibition of noradrenaline release. PMID- 4344330 TI - [Hyperlipemias due to alcohol]. PMID- 4344329 TI - Studies on the mechanism of action of dantrolene sodium. A skeletal muscle relaxant. PMID- 4344332 TI - [5 Cases of soft tissue sarcomas in infants and children]. PMID- 4344331 TI - [Cytomegalic disease: widespread infection with rarely recognized symptoms]. PMID- 4344333 TI - [Normalization of sleep in migraine]. PMID- 4344334 TI - [Renovascular hypertension: pathophysiology and operative indications]. PMID- 4344335 TI - [Continuous objective control of the effect of myorelaxants in anesthesiologic practice (myorelaxography)]. PMID- 4344336 TI - [Pathological anatomy of tumors and of tumor like ovarian changes in children]. PMID- 4344337 TI - Ultrastructural data on the neurogenic origin of Abrikossoff's tumour. PMID- 4344338 TI - A method for the light microscopic use of half-thin sections. PMID- 4344339 TI - Chloroquine-induced alterations in rat sensory ganglia cultivated in vitro. A light and electron microscope study. PMID- 4344340 TI - Ultrastructure of the central nervous system after prolonged hypoxia. I. Neuronal alterations. PMID- 4344341 TI - Ultrastructure of the central nervous system after prolonged hypoxia. II. Neuroglia and blood vessels. PMID- 4344343 TI - The Tecumseh study of respiratory illness. IV. Prevalence of rhinovirus serotypes, 1966-1969. PMID- 4344342 TI - Effect of L-DOPA on motor behavior in a rat with a unilateral striatal neoplasm. PMID- 4344344 TI - The effect of adrenocorticotropic hormone and dexamethasone, administered to the fetus in utero, upon maternal and fetal eestrogens. PMID- 4344345 TI - Estrogen receptors in human breast cancer tissue. PMID- 4344346 TI - Adrenocortical and ovarian function in the hirsute woman. PMID- 4344347 TI - Lupus erythematosus. PMID- 4344348 TI - [Mandelonitrile-glycosides in cancer research and cancer therapy. The amygdalin problem]. PMID- 4344349 TI - Isolation and characterization of renin-like enzymes from mouse submaxillary glands. PMID- 4344350 TI - Isolation of islets of Langerhans for transplantation. PMID- 4344351 TI - Autoantibodies to serum lipoproteins. PMID- 4344352 TI - Brain stem encephalitis caused by Herpesvirus hominis. PMID- 4344353 TI - Diazoxide. PMID- 4344354 TI - [Detection of diamorphine (heroin) and its metabolites in the addict's urine]. PMID- 4344355 TI - [Radioimmunological determination of cyclic 3',5'-AMP. Preparation, purification and checking of tyrosine-succinyl-AMPc and of its iodinated derivatives]. PMID- 4344356 TI - Effect of catecholamines and dibutyryl-cyclic-AMP on glucose turnover, plasma free fatty acids, and insulin in dogs treated with methylprednisolone. PMID- 4344357 TI - Lowered ovarian conversion of 14C-pregnenolone to progesterone and other metabolites during phenobarbital (PB) block of PMS-induced ovulation in immature rats: inhibition of 3beta-hydroxysteroid dehydrogenation. PMID- 4344358 TI - An ultrastructural stereologic study of the effects of ACTH and adenosine 3',5' cyclic monophosphate on the zona glomerulosa of rat adrenal cortex. PMID- 4344359 TI - Corticosteroid levels in adrenal cell suspensions and plasma from normal and adrenal regenerating rats. PMID- 4344361 TI - Adrenocortical hormones and the deposition of liver glycogen in the rat fetus. PMID- 4344360 TI - Cell differentiation of juvenile chicken testes. I. Androgen synthetic capabilities in vitro. PMID- 4344362 TI - Serum LH levels in prepubertal female pigs chronically treated with synthetic luteinizing hormone-releasing hormone-follicle stimulating hormone-releasing hormone (LH-RH-FSH-RH). PMID- 4344363 TI - Stimulation of cyclic AMP production by the rat testis during incubation with hCG in vitro. PMID- 4344364 TI - Purification and biochemical properties of Clostridium perfringens type A enterotoxin. AB - The sporulation-specific enterotoxin of Clostridium perfringens type A, which is the toxin active in human food poisoning, has been purified from extracts of sporulating cells. Highly purified enterotoxin was obtained by treatment of crude cell extract with ribonuclease for 30 min, followed by sequential chromatography on Sephadex G-100, Cellex T cellulose, and hydroxylapatite. Recovery was 65 to 75% of the initial activity. Enterotoxin purity was > 99% as indicated by sedimentation velocity, sedimentation equilibrium, disc electrophoresis, and serological methods. Purified enterotoxin focused at pH 4.3 during isoelectric focusing. Molecular weights of 34,000 and 35,000 were obtained by Sephadex G-100 chromatography and sedimentation equilibrium, respectively. An S(20,w) of 3.08 was obtained for the purified enterotoxin. The enterotoxin precipitated heavily at its isoelectric point and at concentrations greater than 4 mg/ml. PMID- 4344365 TI - Interaction of complement and polymyxin with gram-negative bacteria. AB - The interaction of complement and polymyxin with gram-negative bacteria has been investigated by using three strains of Salmonella typhimurium in an attempt to determine the loci of complement action. It has been shown that the bactericidal activities of complement and polymyxin towards a smooth gram-negative organism are similarly affected by various components of the bactericidal test system. Further, complement and polymyxin have been shown to act synergistically in the bactericidal event. Evidence is presented which suggests that each agent produces lesions in the outer membrane of gram-negative bacteria, allowing lysozyme to interact with its glycopeptide substrate. An attack on the inner cytoplasmic membrane follows, since cell respiration is rapidly inhibited and this membrane becomes sufficiently disorganized to permit massive leakage of beta-galactosidase from the cytoplasm of the target cells. PMID- 4344366 TI - Foot-and-mouth disease: changes in serum-neutralizing activity of immunized cattle shortly after virus exposure. AB - After infection of the upper respiratory tract with foot-and-mouth disease (FMD) virus in immunized cattle, a drop in specific serum-neutralizing antibody activity was observed. Vaccinated cattle with high preexposure serum antibody titers had a precipitous drop for the first 4 days after virus exposure, followed by a rise in titer. This drop was also seen in passively immunized cattle with high preexposure titers; however, their antibody titers decreased for 5 to 7 days after exposure to virus. Some vaccinated and passively immunized cattle with low preexposure antibody titers showed fluctuations in their titers shortly after exposure. These data suggest that the course of infection with FMD virus in immunized cattle depends on the rapidity of new antibody formation as well as on the level of neutralizing antibody titer at the time of exposure. PMID- 4344368 TI - Comparative studies of plaque variantes derived from a Florida strain of Venezuelan equine encephlomyelitis virus. AB - Small- and large-plaque variants of a Florida strain (Fe 3-7c) of Venezuelan equine encephalomyelitis virus were studied in vivo and in vitro. The small plaque variant was less virulent in mice, hamsters, and guinea pigs than the large-plaque variant. The variants could be distinguished by calcium phosphate chromatography. The implications of plaque variants within a mixed virus population are discussed. PMID- 4344370 TI - Preparation of a number of 5-butylpyrimidine nucleosides. PMID- 4344369 TI - Mouse liver fructose-1, 6-diphosphatase and glucose-6-phosphatase activities after endotoxin poisoning. AB - Hepatic fructose-1, 6-diphosphatase and glucose-6-phosphatase were significantly decreased in fasted mice 17 hr after the intraperitioneal injection of a median lethal dose of Salmonella typhimurium endotoxin. Liver glycogen levels were essentially depleted at 17 hr. PMID- 4344367 TI - Hyporeactivity of infection: potential limitation to therapeutic use of interferon-inducing agents. AB - Interferon inducers are generally most effective as antiviral agents when used prophylactically. One possible explanation for this is that animals develop a state of hyporeactivity during the course of a virus infection. Such a progressive loss of capacity to produce interferon was observed with a representative group of interferon-inducing agents (polyinosinic-cytidylic acid, Tilorone hydrochloride, New-castle disease virus, or a strain of encephalomyocarditis virus) during the course of a model picornavirus infection in mice. PMID- 4344372 TI - [Functional currents of rabbit's retina under the influence of compounds affecting carbohydrate metabolism]. PMID- 4344371 TI - [Effect of cryopexy on the enzymatic transformation in the paraoral region of rabbit's retina]. PMID- 4344373 TI - [Biological diagnosis of primary liver cancer]. PMID- 4344374 TI - [Familial NADH diaphorase deficiency]. PMID- 4344375 TI - A genetic locus for inducibility of C-type in BALB-c cells: the effect of a nonlinked regulatory gene on detection of virus after chemical activation. AB - Previous studies have shown that chemicals can transiently activate endogenous C type viruses from embryo cells of the BALB/c mouse strain, but not from cells of another mouse strain, NIH Swiss. The number of genetic loci for inducibility of endogenous virus in BALB/c cells was investigated with cell lines derived from appropriate, F(1), F(2)-hybrid, and backcross generation embryos of these strains. A single genetic locus responsible for inducibility of virus in BALB/c cells was detected, and tentatively designated Ind. A second locus, previously described in studies of mouse-cell susceptibility to exogenous virus infection, Fv-1, was found to be genetically nonlinked to Ind. This regulatory gene plays an important role in determining whether the induced viruses of BALB/c cells can persist after chemical activation. PMID- 4344376 TI - [Hydrocyanic acid demonstration during autopsy in peroral cyanide poisoning]. PMID- 4344377 TI - Ependymal and subependymal cells of the caudato-pallial junction in the lateral ventricle of the neonatal rabbit. PMID- 4344378 TI - [Identification by immunofluorescence of the corticotropin and melanotropin cells in the amphibian pituitary gland]. PMID- 4344379 TI - [Corticotropic cells of the amphibian pituitary gland following interrenalectomy. Cytoimmunochemical and ultrastructural study]. PMID- 4344380 TI - Studies on the post-capillary high endothelial venules of neonatally thymectomized mice. PMID- 4344381 TI - Inter- and intracisternal elements of the Golgi apparatus. A system of membrane to-membrane cross-links. PMID- 4344382 TI - Granular cell tumor (myoblastoma) of the stomach. A case report with ultrastructural findings and review the literature. PMID- 4344383 TI - The effect of estrogens on carbohydrate metabolism: glucose, insulin, and growth hormone studies on one hundred and seventy-one women ingesting Premarin, mestranol, and ethinyl estradiol for six months. PMID- 4344385 TI - Dietary fibre and calcium metabolism. PMID- 4344386 TI - Alterations in the microphysiology of glial cells and neurons and their environment in injured brain. PMID- 4344384 TI - Neuropsychiatric problems in systemic lupus erythematosus. PMID- 4344387 TI - Some characteristics of nocturnal penile tumescence in early middle-aged males. PMID- 4344389 TI - Dendritic ramifications in some nuclei of the rat hypothalamus. PMID- 4344390 TI - [Effect of ACTH and cortisone on carbohydrate-protein complexes of white rat's gastric mucosa]. PMID- 4344391 TI - [Medical follow-up of diamond polishers]. PMID- 4344388 TI - The application of magnetic resonance methods to the study of enzyme structures and action. PMID- 4344393 TI - Interferon in nasal secretions and sera of calves after intranasal administration of avirulent infectious bovine rhinotracheitis virus: association of interferon in nasal secretions with early resistance to challenge with virulent virus. AB - Calves which had received avirulent infectious bovine rhinotracheitis virus (AV IBR) by intranasal (IN) administration developed detectable levels of interferon (IF) in nasal secretions as early as 40 hr later. Peak titers (1:640) of IF appeared in secretions 72 to 96 hr after administration of virus, and titers of 1:80 to 1:320 were maintained through the 8th day. Lower titers (1:5 to 1:10) of IF were detected in sera obtained on the 4th to 8th days after administration of virus. Peak titers of IF in respiratory tract secretions were accompanied by a 100- to > 1,000-fold reduction in the levels of AV-IBR present in the secretions. Serum antibody was not detected prior to the 8th day after administration of AV IBR. Calves which received AV-IBR by the IN route 72 or 96 hr earlier were refractory to challenge with virulent infectious bovine rhinotracheitis virus (IBR), whereas calves receiving AV-IBR 18 or 40 hr earlier became clinically ill following challenge. The temporal association between appearance of IF in respiratory tract secretions and onset of protection against challenge suggests a cause and effect relationship. No IF was detected in either nasal secretions or sera of calves receiving modified IBR virus by intramuscular injection. Following subsequent IN challenge of these calves, IF was detected in nasal secretions as early as 24 hr postchallenge and was maintained at titers of 1:40 to 1:80 for approximately 4 days, even in the absence of virus recovery. Greater ease of local IF induction with IBR virus in calves previously sensitized with that virus is suggested. PMID- 4344392 TI - Differential susceptibility of male and female mice to encephalomyocarditis virus: effects of castration, adrenalectomy, and the administration of sex hormones. AB - Male mice have been noted to be more susceptible to encephalomyocarditis (EMC) virus than female animals. Castration of male mice abolished this difference and resulted in enhanced resistance similar to that of female mice. This increase in resistance in castrated males could be eliminated by adrenalectomy. Adrenalectomy alone increased susceptibility in male mice but not in female mice. The administration of a long-acting preparation of testosterone markedly increased susceptibility both in castrated male and female mice, as well as in intact females. Testosterone also had a similar effect in immature mice of both sexes. On the other hand, estradiol, but not progesterone, increased susceptibility to EMC virus in castrated mice of both sexes. These data indicate that testicular, ovarian, and adrenal hormones may influence resistance to EMC virus in the mouse and may be critical determinants of the clinical outcome of infection with this virus. PMID- 4344394 TI - Time relationships between injection of antigen and adjuvant. 3. Adjuvancy of Bordetella pertussis given at various times after the primary antigenic stimulus. AB - The adjuvant activity of Bordetella pertussis was investigated, both at the cellular and humoral levels, when the bacterial adjuvant was given at various times after the primary antigenic stimulus of both 2 x 10(7) (suboptimal dose) and 4 x 10(8) (optimal dose) of sheep erythrocytes. In all experiments, both adjuvant and sheep erythrocytes were administered by the intraperitoneal route. Adjuvant activity was measured on the basis of the early and late phases of the primary response and on the degree of priming for the secondary immune reaction. A maximal adjuvant activity was found in mice which had received B. pertussis vaccine simultaneously with the antigen. Adjuvant effectiveness became less as the time interval between the injection of antigen and adjuvant increased. Adjuvancy also depended on the amount of antigen used as the primary antigenic stimulus. With 4 x 10(8) sheep erythrocytes, significantly increased priming for the secondary response was produced only when B. pertussis cells were administered within a period of 24 hr. When the bacterial adjuvant was administered either 48 or 72 hr after the primary antigenic stimulus, adjuvancy was found to be limited to the late phase of the primary response and to the prolonged development of antibody-forming cells during the secondary immune reaction. In contrast, significantly enhanced priming for the secondary response was detectable when the adjuvant was administered as late as 48 hr after primary immunization with 2 x 10(7) sheep erythrocytes. When the bacterial adjuvant was administered either 6, 24, 48, or 72 hr after the primary immunization with 2 x 10(7) sheep erythrocytes, the early phase of the primary 19S and 7S hemolysin response was found to be suppressed, and adjuvancy became detectable only thereafter. PMID- 4344395 TI - Nasal secretion protein responses in patients with wild-type adenovirus disease. AB - Proteins were studied in nasal secretions obtained from Marine Corps trainees infected with wild adenovirus type 7 both during the acute phase of illness and after recovery. Illness was associated with a marked increase in the concentration of serum proteins in the secretions, and during inflammation there was no apparent barrier to the passage of large molecules (molecular weight 775,000) from the serum into the respiratory passages. At the time of virus isolation, trainees requiring hospitalization had less immunoglobulin A (IgA) in their secretions even though they had greater quantities of immunoglobin G (P < 0.05) and albumin than trainees followed in the field, whose secretions were also tested at the time of virus isolation. Base-line IgA and protein concentrations were lower (P < 0.05) in hospitalized trainees than in trainees followed prospectively in the field. The results suggest a nonspecific protective function for secretion protein, although we have not excluded the possibility that field study trainees were protected by specific neutralizing antibody present in the nasal secretion. PMID- 4344397 TI - Murine resistance to inhaled Neisseria meningitidis after infection with an encephalomyocarditis virus. AB - A reduction in pulmonary anti-bacterial activity due to a preceding viral illness has been suggested as the mechanism responsible for some meningococcal infections of the lung. We investigated this proposed pathogenesis by infecting mice with airborne encephalomyocarditis virus (EMC) and then challenging them 1, 4, and 7 days later with aerosols of Neisseria meningitidis. Meningococcal clearance was assessed by comparing the numbers of bacteria present immediately after inhaling the aerosols with the numbers present 3 hr later. To insure that EMC virus adequately depressed murine defense mechanisms, we also determined staphylococcal killing rates at 4 hr by using radiophosphorus-labeled staphylococcal aerosols. Viral infection depressed murine pulmonary antimeningococcal activity at 1 and 4 days (P < 0.01) but not at 7 days. Intrapulmonary staphylococcal killing was impaired on day 4 (P < 0.01) but not on days 1 or 7. Pulmonary viral titers decreased rapidly from 10(7) to 10(3) plaque-forming units/ml of lung during the experimental period. According to these data viral disease transiently depresses resistance to meningococcal infection. This impairment in host resistance is present while the viral titer is decreasing and follows a relatively similar pattern to the transient decrease noted for staphylococci. PMID- 4344396 TI - Identification of a canine adenovirus (infectious canine hepatitis virus) inhibitor in dog liver extracts as arginase. AB - Extracts of canine liver inhibited growth of infectious canine hepatitis (ICH) virus, a canine adenovirus. Purified extracts from mammalian, but not avian, liver tissue contained the inhibitor, and evidence is presented that the inhibitory factor is the enzyme arginase (arginine ureohydrolase). This study further emphasized the need for arginine in adenovirus growth and may explain some of the difficulties in isolating small amounts of ICH virus from suspensions of liver. PMID- 4344398 TI - Clinical usefulness of evaluation the renin-angiotensin system in hypertension. PMID- 4344399 TI - Neurotrophic regulation of muscle cholinesterase: effects of botulinum toxin and denervation. AB - 1. In order to determine the role of acetylcholine (ACh) transmission in neurotrophic regulation of muscle cholinesterase (ChE), the effects of botulinum toxin treatment were compared with those of denervation, in terms of two fractions of muscle ChE. The sternocleidomastoid muscles of rats were either denervated or injected with botulinum toxin. After 7 days the muscles were frozen, and sequential sections were assayed for acetylcholinesterase activity. By this method, the ChE activity of end-plates (EPChE) and non-end-plate regions (background ChE, BChE) were separately determined.2. The background ChE was reduced to the same extent by botulinum toxin and denervation. This is interpreted to mean that the neurotrophic regulation of BChE may be wholly cholinergic.3. The EPChE was significantly reduced by both treatments, but the effect of botulinum toxin was only half as great as that of denervation. This indicates that EPChE is only partially regulated by ACh transmission. The larger effect of denervation suggests that some non-cholinergic influence may be operating in this situation as well. Disruption of the structural integrity of the end-plate, with consequent loss of binding sites for the ChE, may account for the additional effect of denervation. PMID- 4344401 TI - Estimation of the duration of spermatogenesis in japanese quail, Coturnix coturnix japonica, using antispermatogonial chemicals. PMID- 4344400 TI - Facilitation and inhibition of cell groups within the superior cervical ganglion of the rabbit. AB - 1. The patterns of facilitation and inhibition of the S(a) and S(b) components of the post-ganglionic compound action potential after a single conditioning stimulus were different and dependent on stimulus parameters.2. With submaximal conditioning and test stimuli, the S(a) component showed a phase of early facilitation (40-75 msec after the conditioning stimulus) followed by a prolonged tail of facilitation. With maximal stimuli, early facilitation and late facilitation (700-2000 msec after the conditioning stimulus) were separated by a phase of inhibition or relative inhibition, most pronounced 100-300 msec after the conditioning stimulus.3. During early facilitation, a submaximal S(a) response was facilitated by 33.1 +/- 3.9%, while a maximal S(a) response was facilitated by 14.5 +/- 2.9%.4. Providing preganglionic C fibres were excited, facilitation of the S(b) component remained relatively constant for 40-500 msec after the conditioning stimulus, with no phase of inhibition.5. Early facilitation of submaximal S(a) responses was greatest when the conditioning stimulus excited about 50% of the preganglionic B fibres, but that of maximal responses was greatest when the conditioning stimulus excited all the B fibres. The preganglionic C fibres modulated facilitation of the S(a) component. Maximal facilitation of this component was associated with depression of the S(b) component.6. Submaximal S(a) responses are more strongly inhibited than maximal S(a) responses 200 msec after a conditioning stimulus. The C fibre pathway seems able to modulate the degree of inhibition of the S(a) ganglion cells.7. A neuronal model with divergent and convergent preganglionic B and C fibres supplying S(a) ganglion cells is consistent with the results. The preganglionic input is able to vary the size of the subliminal fringe. The S(b) component is in part due to the S(a) ganglion cells firing to their C fibre input. PMID- 4344402 TI - [Neuropsychiatric syndromes in rheumatic and pararheumatic diseases]. PMID- 4344403 TI - Rubella immunization. PMID- 4344405 TI - [Pathogenesis, etiology and treatment of renal osteopathy]. PMID- 4344404 TI - Pinocytosis as the cause of sucrose nephrosis. PMID- 4344406 TI - The radiological findings in malignant synovialoma. PMID- 4344407 TI - [Transumbilical portohepatography using oily contrast media in liver metastases]. PMID- 4344408 TI - [Follow-up and supplementary therapy in cancer patients]. PMID- 4344409 TI - Chronic immunosuppression and occult lymphoma: a case report. PMID- 4344410 TI - [Comparative cytophotometric study of the DNA content in cell nuclei of Zajdela ascites hepatoma and its metastases into the paratracheal lymph nodes]. PMID- 4344412 TI - Saccadic displacements of the retinal image: effects on the visual system in the cat. PMID- 4344411 TI - [Stimulation of protein synthesis in normal and tumor cells by agents modifying the cell surface]. PMID- 4344413 TI - [Hypertensin for pharmacodynamic diagnostics in child cardiology]. PMID- 4344414 TI - Group health work in a hostile environment: the U.S. Public Health Service. PMID- 4344415 TI - Granular cell tumors of the biliary tract. PMID- 4344416 TI - [Acute erythremia]. PMID- 4344418 TI - Effect of prostaglandin E 1 and E 2 on the vascular responsiveness to adrenaline, noradrenaline, angiotensin and vasopressin. PMID- 4344417 TI - Effects of heparin and clofibrate on blood-serum lipid levels in patients with ischaemic heart disease. PMID- 4344419 TI - Digital computer analyzed sleep electroencephalogram (sleep prints) in predicting anxiolytic properties of clorazepate dipotassium (tranxene). PMID- 4344421 TI - [Epstein-Barr virus infection in infancy: bronchopneumonia in a four-month-old child with subsequently acquired cytomegalic infection]. PMID- 4344420 TI - The effects of SU-21707 on the sleep electroencephalogram of normal subjects. PMID- 4344422 TI - [Effective mechanisms of hormones from the viewpoint of molecular biology]. PMID- 4344423 TI - Efflux of amino acid neurotransmitters from brain slices: role of membrane transport. PMID- 4344424 TI - Chemically induced porphyria: protection by treatment with nicotinic acid. PMID- 4344425 TI - Inhibition of the vasopressin-activated adenyl cyclase from renal medulla by prostaglandins. PMID- 4344426 TI - Potentiation of monoaminergic activity in peripheral ganglia by tricyclic antidepressants. PMID- 4344427 TI - Suppression of cell firing in the substantia nigra by caudate nucleus stimulation. PMID- 4344428 TI - Spread of transcallosally evoked responses in immature association cortex. PMID- 4344429 TI - Multiunit activity with eye movements during fast-wave sleep in cats. PMID- 4344430 TI - Juvenile nasopharyngeal angiofibroma. PMID- 4344432 TI - Fatal postpartum amoebic colitis with trophozoites present in peritoneal fluid. PMID- 4344431 TI - Corticosteroids and the development of intrinsic factor-mediated vitamin B 12 absorption in the rat. PMID- 4344433 TI - Antifertility effect of Ocimum sanctum L. PMID- 4344434 TI - Production of extracellular fungal collagenase. PMID- 4344435 TI - [Epidemiology of breast cancer]. PMID- 4344436 TI - [Symposium: metabolism in neurological disorders. 2. The peripheral neuropathies. 2-(1). Correlation between pathological alterations and functional disorders in the peripheral neuropathies]. PMID- 4344438 TI - [Symposium: neurological diseases and metabolism. 2. The peripheral neuropathies. A study on neuropathy of uremia]. PMID- 4344437 TI - [Symposium: metabolism in neurological disorders. 2. The peripheral neuropathies. 2-(2). Quantitative studies on sural nerves in patients with peripheral nerve diseases and control subjects]. PMID- 4344440 TI - [Nervous system diseases and metabolism]. PMID- 4344439 TI - [Symposium: metabolism in neurological disorders. 3. Myopathy. 3-(2). Muscle enzymes and myopathy]. PMID- 4344441 TI - [Terebrant and recurring herpes and zona in the course of hemopathies (treated with immunosuppressive agents)]. PMID- 4344442 TI - Postoperative urinary bladder irrigation in the female; a controlled trial. PMID- 4344443 TI - Maternal virilization developing during a twin pregnancy demonstration of excess ovarian androgen production associated with theca lutein cysts. PMID- 4344444 TI - Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 3-1973. PMID- 4344445 TI - Streptozotocin for non-beta islet cell cancer. PMID- 4344446 TI - Effects of desipramine and imipramine on the nerve, muscle and synaptic transmission of rat diaphragms. PMID- 4344447 TI - Drug-induced syndromes in rats with large, chronic lesions in the corpus striatum. PMID- 4344448 TI - [Arteriography of retroperitoneal malignant tumors in childhood]. PMID- 4344449 TI - [Radiological aspects of renal pseudotumors in children]. PMID- 4344450 TI - The control of sensitivity in the retina. PMID- 4344451 TI - [Adenosine nucleotides and radiation sensitivity]. PMID- 4344452 TI - [Criteria for age determination in man by closure of cranial sutures]. PMID- 4344453 TI - [Inorganic composition of tibial and fibular epiphyses in the fetus and newborn in relation to age]. PMID- 4344454 TI - Tumor cell invasion of hepatocytes in transplantable plasma cell neoplasm of mice. PMID- 4344455 TI - [Morphological studies on the occlusion and reopening of proximal kidney tubules in ischemia of short duration]. PMID- 4344456 TI - Contractility and histochemistry of the myoid cell layer of the rat seminiferous tubules during postnatal development. PMID- 4344457 TI - Cell types of human fetal superior cervical ganglion. PMID- 4344458 TI - [Structure of a vestibular paraganglion in the mouse]. PMID- 4344459 TI - [Differentiation of chick embryo lung buds in heterochronic grafts: an ultra structural study of lamellay and granular inclusions]. PMID- 4344461 TI - Effect of hydrocortisone on the ultrastructure of the small, intensely fluorescent, granule-containing cells in cultures of sympathetic ganglia of newborn rats. PMID- 4344462 TI - The neurohypophysis of the crested newt. II. Fine structure of the pars nervosa with special reference to ependymal cells. PMID- 4344460 TI - Fine structure of the carotid body of the midterm human fetus. PMID- 4344463 TI - The effects of host deprivation on the calyx cells of Nasonia vitripennis (Walker) (Hymenoptera: Pteromalidae). PMID- 4344464 TI - [Fine structure of the choroid plexus in monkeys and apes]. PMID- 4344465 TI - [Case report on the morphological and clinical aspects of hidradenoma vulvae]. PMID- 4344466 TI - Gas chromatography of bacterial whole cell methanolysates. I. The usefulness of trimethylsilyl- and trifluoroacetyl derivatives for strain and species characterization. PMID- 4344467 TI - Gas chromatography of bacterial whole cell methanolysates. II. A taxonomic evaluation of the method for species of Moraxella. PMID- 4344468 TI - Gas chromatography of bacterial whole cell methanolysates. 3. Group relations of Neisseriae and Moraxellae. PMID- 4344469 TI - Facilitation from ipsilateral primary afferents of interneuronal transmission in the Ia inhibitory pathway to motoneurones. PMID- 4344470 TI - The endocrine response to trauma. PMID- 4344471 TI - [Influence of surgical stress on adrenal cortex sensitivity to exogenous corticotropin]. PMID- 4344472 TI - [Pigmentation due to amiodarone hydrochloride (6 cases with electron microscopy study)]. PMID- 4344473 TI - Alcohol and presynaptic inhibition in an isolated spinal cord preparation. PMID- 4344475 TI - Subunit interactions and ligand binding in supernatant malic dehydrogenase. Cooperative binding of reduced nicotinamide adenine dinucleotide associated with a monomer-dimer equilibrium of the protein. PMID- 4344474 TI - A novel procedure for the synthesis of 2'-O-alkyl nucleotides. PMID- 4344477 TI - [Modification of structural transitions of supramolecular nucleoprotein systems induced by the protein component of deoxyribonucleoprotein from malignant cells]. PMID- 4344476 TI - [Histochemistry of the spleen and thymus in allogeneic disease]. PMID- 4344478 TI - [Effect of heat on corticosterone level and binding capacity of blood plasma proteins]. PMID- 4344479 TI - [Immunologic study of tumors induced in adult mice by highly oncogenic variants of Rous virus]. PMID- 4344480 TI - [Localization of albumin and transferrin in mouse liver]. PMID- 4344481 TI - Multiple primary malignancies. PMID- 4344482 TI - Ultrastructural cytochemistry of the aldehyde-sensitive enzymes. Localization of glucose 6-phosphatase activity in mouse hepatocytes. PMID- 4344483 TI - [Neurobrucellosis (study of 41 cases)]. PMID- 4344484 TI - Thalassemic hydrops fetalis in two Chinese-Canadian families. AB - Two unrelated Chinese-Canadian families with recurrent hydrops fetalis are described. The investigation, acid-base and blood gas studies, and clinical course of one hydropic fetus with large amounts of hemoglobin Bart's who survived for three hours are described. Data for the parents of both families, consistent with the alphathalassemia carrier state, are presented. PMID- 4344485 TI - Non-hormonal drugs for the treatment of diabetes insipidus. AB - Patients with diabetes insipidus may be successfully controlled with drugs other than vasopressin. These have the advantage of being effective when administered orally. The most important are the diuretics and the hypoglycemic agent chlorpropamide. The mode of action, indications and side effects of these drugs are reviewed. A third potentially useful agent is clofibrate. Recent experience with this drug has been described but more observations are needed before its possible role in the management of diabetes insipidus can be established. PMID- 4344486 TI - Light and electron microscopy of rat kangaroo cells in mitosis. I. Formation and breakdown of the mitotic apparatus. PMID- 4344487 TI - [Radiological findings in less known inflammatory and other benign kidney diseases]. PMID- 4344488 TI - [Radiological diagnosis of inflammatory kidney diseases with special reference to the electron subtraction and harmonizing technic]. PMID- 4344489 TI - [Separate determination of the effective kidney plasma stream--comparison between nuclear medicine and classical determination methods]. PMID- 4344491 TI - [Pyelonephritis diagnosis and errors in clinical practice. Statistical evaluation]. PMID- 4344490 TI - [Results and interpretation of studies on calcium retention in persons suffering from kidney diseases using a whole-body counter]. PMID- 4344493 TI - [Diagnostic value of urography, renovasography and kidney scanning in the diagnosis of cystic kidney changes]. PMID- 4344494 TI - [Limitations of angiographic diagnosis in parenchymal kidney processes]. PMID- 4344495 TI - [Special value of angiography in parenchymal kidney diseases]. PMID- 4344492 TI - [Comparative studies on the diagnostic value of the i.v.-pyelogram, infusion nephrotomogram and renovasography in parenchymal kidney diseases]. PMID- 4344497 TI - [Selective renal angioscintiscan (perfusion scintiscan) in comparison with angiography]. PMID- 4344496 TI - [Comparative studies on the diagnostic value of the angioscintiscan, angiography and scintiscan of the kidneys]. PMID- 4344498 TI - [Lateral angiographic projection of the kidney]. PMID- 4344499 TI - [Radiation exposure in clearance studies of the kidney]. PMID- 4344501 TI - [Fractionation studies on transplantable animal tumors with reference to cell kinetic aspects]. PMID- 4344500 TI - [Functional scintigraphy of the kidney using tubular and glomerular excreted substances]. PMID- 4344502 TI - [Determination of cell loss rates in experimental tumors, in-vivo measurements using labeled iodine-deoxy-uridine]. PMID- 4344503 TI - [The kidney scintigram and radioisotope nephrogram as screening tests in uroradiologic routine diagnosis]. PMID- 4344504 TI - [Methods and results of kidney function tests using radioactively labelled hippuran and chlormerodrin in parenchymal kidney diseases]. PMID- 4344506 TI - [Isotope nephrographic functional evaluation of mobile kidneys]. PMID- 4344505 TI - [Control of renal excretion dynamics using the isotopen nephrogram in percutaneous gamma teletherapy]. PMID- 4344507 TI - [Critical analysis of radioisotope renographic results in 534 patients with internal diseases]. PMID- 4344508 TI - [Nuclear medicine diagnosis of parenchymal kidney lesions]. PMID- 4344509 TI - [Radiomorphology of renal tuberculosis with arguments for a simplified stage classification with reference to therapeutic viewpoints]. PMID- 4344510 TI - [Radiographic and nuclear medicine studies in the diagnosis and course resp. therapeutic control of renal tuberculosis]. PMID- 4344511 TI - [Selective renal angiography in the evaluation of morphology and therapy of renal tuberculosis]. PMID- 4344512 TI - [Radiotherapy following synchronisation of the cell-division rhythm]. PMID- 4344513 TI - [Intravital angiography of kidney grafts]. PMID- 4344514 TI - [Microangiographic, histologic and morphometric studies on human kidney grafts]. PMID- 4344515 TI - [Dominant problem in tomography]. PMID- 4344516 TI - [Rotation anode tubes with increased load capacity specially for serial radiography]. PMID- 4344517 TI - [Broad-field image intensifier with film tube]. PMID- 4344518 TI - [Indication and technic of the 70 mm image intensification in urologic diagnosis]. PMID- 4344519 TI - [Tumor scintigraphy using 67 Ga citrate]. PMID- 4344520 TI - [Use of multiple color registration of iso-intensity zones in camera scintigrams]. PMID- 4344521 TI - [The medichrome procedure]. PMID- 4344522 TI - [Studies on the effect of ozone on tumor growth and radiation effect (animal experiments)]. PMID- 4344523 TI - [Thermography as a method for tumor diagnosis]. PMID- 4344524 TI - [Examples of electronic data processing in radiotherapy]. PMID- 4344526 TI - [Microdosimetry of electron radiation]. PMID- 4344525 TI - [Linear accelerator in radiotherapy]. PMID- 4344528 TI - [Studies on the demonstration of alpha-ray energy deposition in smallest bands]. PMID- 4344527 TI - [Microdosimetry using a spheroid proportion counter without a wall]. PMID- 4344529 TI - [Physical criteria for the evaluation of ray quality of fast ions]. PMID- 4344530 TI - [Influences of inhomogeneities on dose distribution of fast electrons up to 42 MeV]. PMID- 4344531 TI - [Influence of electron diffusion on dose distribution in inhomogenous media]. PMID- 4344532 TI - [Calorimetric measurements of energy flow density of soft x-rays]. PMID- 4344533 TI - [Calibration of electron dosimeters]. PMID- 4344534 TI - [The Ge(Li) detector as a solid body ionisation chamber]. PMID- 4344535 TI - [Precision in the demonstration of electronically counted section filters in cobalt teletherapy]. PMID- 4344536 TI - [Development and use of an isodose computing program used for the preparation of optimal irradiation plans]. PMID- 4344537 TI - [Electronic site computation of radium following stereometric x-ray pictures and its relation ot bladder and intestinal load]. PMID- 4344538 TI - [Simulation of kinetoirradiation and grid size in electronic computation of single fields and standard plans for cobalt teletherapy]. PMID- 4344539 TI - [Radiation pathology of the skeletal system]. PMID- 4344540 TI - [Changes of bone macro and microstructure in osteoradionecrosis]. PMID- 4344541 TI - [Radiation injuries and reparation processes in growth seams of rat tail vertebrae]. PMID- 4344542 TI - [Disorders of calcium metabolism following x-ray irradiation of the rat knee]. PMID- 4344543 TI - [Late lesions following incorporation of 224Ra in animal experiment]. PMID- 4344545 TI - [Recent problems of radionuclide decomposition]. PMID- 4344544 TI - [Experimental studies on the tumor uptake of mercury isotope labeled compounds]. PMID- 4344546 TI - [Time factor study on radiation fibrosis of the subcutis following cobalt teletherapy]. PMID- 4344547 TI - [Radiosensitivity of tissues (lung and kidney) in gamma teletherapy with different fractionations]. PMID- 4344548 TI - [Experimental findings in local radioresistance following local pre-irradiation]. PMID- 4344549 TI - [Autoradiographic studies on the recuperative capacity of murine small intestine epithelium following repeated partial body irradiation]. PMID- 4344550 TI - [German Roentgen Congress 1970]. PMID- 4344551 TI - [Experimental and clinical experiences with various doses and fractionations in radiotherapy]. PMID- 4344552 TI - [Mathematical model for the description of kinetics and time factors in radiation induced inhibition of mitosis]. PMID- 4344553 TI - [Biophysical model for radiotherapy with fractionated doses]. PMID- 4344554 TI - [Influence of temporal dose distribution on the colony-forming capacity of diploid yeast cells in dependence on cellular energy metabolism]. PMID- 4344555 TI - [Proliferative behavior of irradiated vertebrate cells in vitro]. PMID- 4344557 TI - [Quantitative and qualitative changes of bone marrow following partial body irradiation in dependence on dose and time]. PMID- 4344556 TI - [Hematologic radiation effects in dependence on the radiosensitivity of stem cells]. PMID- 4344558 TI - [Studies on the erythropoietic bone marrow size in man]. PMID- 4344559 TI - [New results in radio-iron kinetics]. PMID- 4344560 TI - [Course observations on 59 Fe bone marrow topography in the myeloproliferative process]. PMID- 4344561 TI - [Improvement of radiotherapy with reference to the radio-biological viewpoints. 7 year experience report]. PMID- 4344562 TI - [Therapeutic effect in collum carcinoma following fractionated radium-cobalt teletherapy]. PMID- 4344563 TI - [Studies on the therapy of radiation injury and its dependence on the activity of the erythropoietic system]. PMID- 4344564 TI - [Electronic differentiation of radiation-induced cell changes in the circulating blood]. PMID- 4344565 TI - [Acute abdomen in childhood]. PMID- 4344566 TI - [Diagnostic x-ray of digestive system inflammations in childhood]. PMID- 4344567 TI - [Nuclear medicine diagnostics of the infantile abdomen]. PMID- 4344568 TI - [Radiological evaluation of cardia function in habitual emesis of the infant]. PMID- 4344569 TI - [Radiologic diagnosis of abdominal tumors in childhood]. PMID- 4344570 TI - [Abdominal angiography in childhood]. PMID- 4344571 TI - [The infantile portal vein in diseases of the upper abdominal organs]. PMID- 4344572 TI - [Radiologic diagnosis of the infantile acute abdomen from the urologist's viewpoint]. PMID- 4344573 TI - [Radioisotope renography and scanning in congenital renal and urinary tract abnormalities in childhood]. PMID- 4344574 TI - [Pathology of renal tumors]. PMID- 4344575 TI - [Surgical treatment of kidney tumors]. PMID- 4344576 TI - [Role of radiotherapy in the treatment of malignant kidney tumors in adults]. PMID- 4344577 TI - [Preoperative irradiation of kidney tumors from the surgico-urologic viewpoint]. PMID- 4344578 TI - [Postoperative radiotherapy of renal adenocarcinoma]. PMID- 4344580 TI - [Results of combined surgico-radiological treatment of renal tumors]. PMID- 4344579 TI - [Cobalt teletherapy of kidney tumors]. PMID- 4344581 TI - [Postoperative cobalt teletherapy of renal carcinomas using rotation about 3 partial angles]. PMID- 4344582 TI - [Radiotherapeutic studies on malignant renal tumors with special reference to whole body x-ray irradiation]. PMID- 4344583 TI - [Focusing technic in cobalt teletherapy of malignant renal tumors]. PMID- 4344584 TI - [Radiation injury of the kidney]. PMID- 4344585 TI - [Physiopathology of radiation induced nephritis]. PMID- 4344587 TI - [Lesions following unilateral kidney irradiation with therapeutic doses. An experimental and clinical study]. PMID- 4344586 TI - [Functional changes of the human kidney during irradiation]. PMID- 4344588 TI - [Studies on relations between radiation dosage, radical formation and radiation injury in lymphocytes]. PMID- 4344589 TI - [Influence of ionizing rays on DNA, RNA and protein metabolism as well as on cell nucleus number in organs of embryonal and newborn animals]. PMID- 4344591 TI - [Activity of cytoplasmic enzymes following directed irradiation of the liver]. PMID- 4344590 TI - [Coagulation, microcirculation and acute radiation reactions of the skin. Comparative study of skin reaction using conventional radiotherapy of breast carcinoma in combination with preventive marcumar-induced coagulation inhibition]. PMID- 4344593 TI - [Continuous measurement of serum electrolytes in rabbits under the effect of ionizing radiation]. PMID- 4344592 TI - [Dependence of liver irradiation reaction on metabolic activity]. PMID- 4344594 TI - [New methods of radium dosage and irradiation planning in collum carcinomas using the 42 megavolt betatron. Report on 152 cases]. PMID- 4344595 TI - [Comparative physiologico-morphological studies on the in-vivo perfused rat jejunum following whole body irradiation]. PMID- 4344597 TI - [Intracerebrally injected 5-hydroxytryptamine: distribution, metabolism and increase of radiation resistance in mice]. PMID- 4344596 TI - [Studies on intermediary metabolism using 14 C glucose in rats following whole body x-ray irradiation]. PMID- 4344598 TI - [Diagnosis of inflammatory rheumatic diseases of the skeletal system]. PMID- 4344599 TI - [X-ray diagnosis of inflammatory rheumatic diseases preferably located in the spine]. PMID- 4344600 TI - [Radiologic differential diagnosis of inflammatory rheumatic diseases preferably located in peripheral joints]. PMID- 4344601 TI - [Structure and calcium content of the bones in rheumatic diseases]. PMID- 4344602 TI - [Quantitative analysis of mineral salts in the skeleton using a two-isotope method]. PMID- 4344603 TI - [Procedure and equipment for the diagnostic use of ultrasonics]. PMID- 4344604 TI - [Echoencephalography as a supplement to neuroradiologic examination methods]. PMID- 4344605 TI - [Diagnosis of space-requiring epigastric processes using the ultrasonic intersection picture method]. PMID- 4344606 TI - [Depth location of the kidney and determination of the parenchymal size using an ultrasonic-intersection picture method before percutaneous kidney biopsy]. PMID- 4344607 TI - [Significance of ultrasonic tomography in the diagnosis of blunt abdominal injuries]. PMID- 4344608 TI - [Abdominal ultrasonic tomography in pediatrics]. PMID- 4344609 TI - [Ultrasonic intersection picture study in obstetrics and gynecology]. PMID- 4344610 TI - [Placenta localisation using scintigraphy and ultrasonics]. PMID- 4344611 TI - [Radiotherapy of malignant ovarian tumors using 42 megavolt photons]. PMID- 4344612 TI - [Functional pelvis diagnostics using ultrasonics in obstetrics]. PMID- 4344613 TI - [Improvement of the radiological and clinical diagnosis of mitral valve defects through ultrasonic cardiography]. PMID- 4344614 TI - [Morphology of human central nervous system irradiation sequelae]. PMID- 4344615 TI - [Use of ultrasonics in radiotherapy]. PMID- 4344616 TI - [Radiosensitivity of the central nervous system]. PMID- 4344617 TI - [Electrophysiological studies on radiation-induced central nervous system changes in the cat]. PMID- 4344618 TI - [Radiation effects on the embryonal and abnormal development of the central nervous system in mammals]. PMID- 4344619 TI - [Histochemical irradiation and O 2 effects on vascularised and nonvascularised retinas]. PMID- 4344620 TI - [Learning and memory capacity of trained quails (Coturnix c. japonica) following irradiation of the head]. PMID- 4344621 TI - [Immediate smooth muscle reactions of mammals (ductus deferens of the guinea pig) to x-ray irradiation]. PMID- 4344623 TI - [Urographic and pyelographic methods in the diagnosis of parenchymal kidney diseases]. PMID- 4344622 TI - [Results of tumor-cell kinetic studies within the scope of puncture cytology]. PMID- 4344624 TI - [Angiographic diagnosis of nontumorous parenchymal kidney diseases]. PMID- 4344625 TI - [Radioisotope nephrography and kidney scintigraphy in parenchymal kidney diseases]. PMID- 4344626 TI - [Nuclear medicine clearance procedures in nephrology]. PMID- 4344627 TI - [Parenchymal changes in inflammatory kidney diseases in the scintigram and x-ray picture]. PMID- 4344628 TI - [I.v. excretion urography and nephrologic diagnosis: comparative results in chronic pyelonephritis and chronic glomerulonephritis]. PMID- 4344629 TI - [Urographically demonstrable changes of the renal hollow system mucosa, a radiological pathological and anatomical synopsis]. PMID- 4344630 TI - [Vessel picture and differential diagnosis of kidney cirrhosis in the postmortal and intravital angiogram]. PMID- 4344631 TI - [Renal arteriovenous fistulas following kidney biopsy. Experimental and clinical observations]. PMID- 4344632 TI - Leucocytosis-promoting factor of Bordetella pertussis. I. Purification and characterization. AB - The leucocytosis-promoting factor was purified from the supernatant fluid of spent cultures of Bordetella pertussis on solid medium. After precipitation at 67% saturation of ammonium sulfate, the leucocytosis-promoting factor was extracted with a 1.0 m NaCl solution. Purification was accomplished by starch block electrophoresis and sucrose density gradient centrifugation. The purified preparation contained a high leucocytosis-promoting activity, and as small an amount as 0.04 mug of protein induced leucocytosis in mice. About 520-fold purification was attained, with a re-recovery of about 25% on an activity basis. The leucocytosis-promoting factor was composed solely of filamentous molecules of about 2 by 40 nm in size, with a sedimentation coefficient of approximately 5.5S and a molecular weight of 108,000. It was insoluble in water but partially soluble in 1.0 m NaCl solution, and consisted mainly of protein, with some carbohydrate, lipid, and phosphorus. PMID- 4344633 TI - Isolation and purification of endotoxin by hydrolytic enzymes. AB - Various commercial hydrolases were used in an attempt to degrade the endotoxic lipopolysaccharide macromolecule. Some inert components, such as peptides and nucleic acids, could be removed from endotoxin preparations. As a result, endotoxic activity, measured by pyrogenicity, Shwartzman reaction, and mouse lethality, was increased. The remarkable resistance of endotoxin to hydrolases led to the use of such enzymes for the liberation and purification of endotoxin from whole bacterial cells. PMID- 4344634 TI - Detection and localization of viruses in human fetal intestinal organ cultures by immunofluorescence. AB - Viral antigens from viruses belonging to four different viral groups were detected directly in human fetal intestinal organ cultures by the application of immunofluorescent techniques. The time of appearance and the cellular localization of fluorescent-stainable antigen varied with the type of virus under investigation. After infection with adenovirus or with adeno-associated virus, fluorescent-stainable antigen was seen in the epithelial cells of the explants, though no light microscopic changes could be observed. In infection with herpes simplex virus and echovirus, fluorescence was noted in both the epithelium and the lamina propria, along with histological changes throughout the organ culture. These techniques offer promise for the investigation of possible viral agents implicated in gastrointestinal disease. PMID- 4344635 TI - Effect of methylprednisolone on some BCG-mediated changes in rabbit alveolar macrophage. AB - The effect of methylprednisolone sodium succinate treatment on Bacillus Calmette Guerin (BCG) immunization was examined in alveolar macrophages of New Zealand White rabbits. Intravenous BCG injection caused a marked increase in cell number and in the hexosemonophosphate shunt activity. There was also a selective augmentation in the activity of acid phosphatase and beta-glucuronidase and an increase in lysosomal density. Activity of the lysosomal phospholipases was decreased. Steroid treatment suppressed the BCG-induced increase in cell number, hexosemonophosphate shunt activity, acid phosphatase, and beta-glucuronidase, and prevented the increase in lysosomal density. On the other hand, steroid treatment increased the activity of the phospholipases to levels higher than either control values or those obtained with cells from BCG-treated rabbits. PMID- 4344636 TI - Chronic rabies virus infection of cell cultures. AB - Exposure of both mammalian and reptilian cells in tissue culture to different strains of fixed rabies virus resulted in a carrier type of infection. No cytopathic effect was observed in either type of culture; infected cultures could be maintained by cell transfer for unlimited numbers of passages. A consistent pattern of cyclically rising and falling levels of viral infection was observed by fluorescent-antibody staining techniques and by titration of released infectious virus. Resistance to super-infection by vesicular stomatis virus and the production of an interferon-like substance by infected cells indicated that the maintenance of a carrier type of infection may be interferon-mediated. The degree of susceptibility of rabies-infected cells to immunolysis by antirabies antibody in the presence of complement was found to be correlated with the amount of virus maturation occurring by budding through the cell membrane and not with the presence of immunofluorescent antigen in the cytoplasm of infected cells. PMID- 4344637 TI - Diagnosis of bovine abortion. PMID- 4344638 TI - Diagnosis of bovine vesicular diseases. PMID- 4344639 TI - Diagnosis of clostridial diseases. PMID- 4344640 TI - Viral zoonoses of importance to laboratory animal personnel. PMID- 4344641 TI - Hormone-dependent phosphorylation of ribosomal and plasma membrane proteins in mouse mammary gland in vitro. PMID- 4344642 TI - Erythrocyte membrane polyphosphoinositide metabolism and the regulation of calcium binding. PMID- 4344645 TI - Ribonucleoside diphosphate reductase induced by bacteriophage Tr. I. Purification and characterization. PMID- 4344643 TI - A comparative study of spin-labeled serine enzymes: acetylcholinesterase, trypsin, -chymotrypsin, elastase, and subtilisin. PMID- 4344644 TI - MOdified nucleosides of nuclear and nucleolar low molecular weight ribonucleic acid. PMID- 4344646 TI - Association of an endoribonuclease with the avian myeloblastosis virus deoxyribonucleic acid polymerase. PMID- 4344647 TI - Yeast inorganic pyrophosphatase. I. Binding of pyrophosphate, metal ion, and metal ion-pyrophosphate complexes. PMID- 4344648 TI - Yeast inorganic pyrophosphatase. 3. Kinetics of Ca 2+ inhibition. PMID- 4344649 TI - Glycogen synthetase-D phosphatase. I. Some new properties of the partially purified enzyme from rabbit skeletal muscle. PMID- 4344651 TI - [Gastroscopic biopsy and cytological diagnosis of gastric cancer--histological and cytological types]. PMID- 4344650 TI - The study of the occurrence of precipitation antibodies to varicella-zoster (VZ) virus in healthy and sick children up to one year of age in relation to their transplacental transfer. PMID- 4344652 TI - [Nonbreakable eyeglasses]. PMID- 4344653 TI - [Therapy of herpetic keratitis using a new adamantan derivative]. PMID- 4344654 TI - [A probable adenovirus panophthalmia in a child]. PMID- 4344656 TI - Goitre and deafness: Pendred's syndrome. PMID- 4344655 TI - Surgery of the hand. 2. PMID- 4344658 TI - [Cytomegalovirus infections]. PMID- 4344657 TI - Interaction of modifiers of hepatic microsomal drug metabolism and the inhalation toxicity of 1,1-dichloroethylene. PMID- 4344659 TI - [Contrast radiography of maxillary sinuses]. PMID- 4344660 TI - [Estrogen conjugates in the adrenal cortex of the mouse]. PMID- 4344661 TI - Oligodendrocytes in the normal and chronically de-afferented lateral geniculate body of the monkey. PMID- 4344662 TI - [Morphology of the bovine ductuli efferentes]. PMID- 4344663 TI - Effects of metopirone on the structure of endocrine glands in the male lizard, Cnemidophorus l. lemniscatus (L.). PMID- 4344664 TI - [Formation of the thecal wall in Centropyxis discoides (Rhizopoda, Testacea)]. PMID- 4344665 TI - [Test formation in Difflugia oviformis (Rhizopoda, Testacea)]. PMID- 4344666 TI - [Thecal morphogenesis in Euglypha rotunda (Rhizopoda, Testecea)]. PMID- 4344667 TI - Elimination of intranuclear glycogen and its transport to the cytoplasm in Ehrlich-Lettre mouse-ascites-tumour. PMID- 4344669 TI - [Craniocerebral injuries. Physiopathology]. PMID- 4344668 TI - [Biochemical events in erythrocyte maturation. Further results on the action site of the respiratory inhibitor F from reticulocytes in the respiratory chain]. PMID- 4344670 TI - [The postoperative cerebral scintillogram]. PMID- 4344671 TI - [Treatment of hypsarrhythmia]. PMID- 4344672 TI - [Spasms in flexion and hypsarrhythmia]. PMID- 4344674 TI - Corticotropic and ADH system in the hypothalamus of the pigeon. PMID- 4344673 TI - Effect on renal function and renin release of hypertonic urea solution infused into the renal artery. PMID- 4344675 TI - Pituitary-adrenal function during lactation and after LTH (prolactin) administration in the rat. PMID- 4344676 TI - Inhibitory action of serotonin on hypothalamus-induced ACTH release. PMID- 4344677 TI - Functional dependence of the ciliary epithelium ATPase activity and intraocular pressure on the autonomic nervous system. PMID- 4344678 TI - The dynamic properties of the acoustic middle ear reflex in nonanesthetized rabbits. Quantitative aspects of a polysynaptic reflex system. PMID- 4344679 TI - Rehospitalization versus family crisis intervention. PMID- 4344680 TI - Pediatric hospitalization as crisis intervention. PMID- 4344681 TI - Fine structure of developing merosporangia and sporangiospores of Syncephalastrum racemosum. PMID- 4344682 TI - A spin-label study of fractionated egg phosphatidyl choline vesicles. PMID- 4344684 TI - Primary amines as uncouplers of electron transport from hydroxylation in the secondary-amine mono-oxygenase system of Pseudomonas aminovorans. PMID- 4344683 TI - Effect of chronic ethanol ingestion on mitochondrial permeability and the transport of reducing equivalents. PMID- 4344685 TI - Pressinoic acid: a peptide with potent corticotrophin-releasing activity. PMID- 4344686 TI - Collagenase and proteinase induction in implants of bone matrix. PMID- 4344688 TI - Re-interpretation of the electron paramagnetic resonance spectra of transferrins. PMID- 4344687 TI - Altered susceptibility of collagen to collagenase digestion as a consequence of exposure to tobacco smoke. PMID- 4344689 TI - Adrenocorticotropin 45. Revised amino acid sequences for sheep and bovine hormones. PMID- 4344692 TI - Isolation of plasma-membrane-associated tumour-specific antigen from rat hepatoma cells. PMID- 4344691 TI - Glycopeptides of the sputum gel phase. PMID- 4344690 TI - Preparation of solubilized insulin receptors from human lymphocytes. PMID- 4344694 TI - Studies on the functional specificity of cortisone reductase. PMID- 4344693 TI - Partial purification and characterization of triokinase from ox and human liver. PMID- 4344695 TI - Studies on the active centre for the 3-hydroxy steroid-nicotinamide-adenine dinucleotide oxidoreductase activity of cortisone reductase. PMID- 4344696 TI - Studies on the reaction of glutamate dehydrogenase with ethoxyformic anhydride. PMID- 4344697 TI - A possible role for 5-phosphoribosyl 1-pyrophosphate in the stimulation of uterine purine nucleotide synthesis in response to oestradiol-17 . AB - 1. It has been reported that the rate of purine nucleotide synthesis de novo in the immature rat uterus is doubled at 6h after administration of oestradiol 17beta. The present work confirms an increased incorporation of glycine and adenine into uterine nucleotides between 2 and 6h after hormone treatment and investigates the mechanism of this response. 2. Activation of regulatory enzymes is unlikely to promote increased nucleotide synthesis: the activities of 5 phosphoribosyl 1-pyrophosphate amidotransferase (EC 2.4.2.14) and adenine phosphoribosyltransferase (EC 2.4.2.7) are the same in uterine extracts from control and oestrogen-treated rats. 3. Therefore it was proposed that oestradiol might promote an increased supply of a rate-limiting substrate. The low oestrogen sensitive rate of AMP synthesis from adenine and endogenous 5-phosphoribosyl 1 pyrophosphate in the intact uterus compared with the high, oestrogen-insensitive rate in uterine extracts supplemented with 5-phosphoribosyl 1-pyrophosphate is evidence that the supply of 5-phosphoribosyl 1-pyrophosphate limits purine nucleotide formation and may increase after hormone treatment. This proposal is supported by the decrease in AMP synthesis in the whole tissue in the presence of guanine and 7-amino-3-(beta-d-ribofuranosyl)pyrazolo[3,4-d]pyrimidine (formycin). These compounds do not inhibit adenine uptake or adenine phosphoribosyltransferase activity, but they both decrease the availability of 5 phosphoribosyl 1-pyrophosphate, the former by promoting its utilization by hypoxanthine/guanine phosphoribosyltransferase (EC 2.4.2.8) and the latter by inhibiting its synthesis from ribose 5-phosphate and ATP by ribose 5-phosphate pyrophosphokinase (EC 2.7.6.1). 4. It is unlikely that the increased availability of 5-phosphoribosyl 1-pyrophosphate results from hormonal stimulation of ribose 5 phosphate formation. Methylene Blue and phenazine methosulphate both increase ribose 5-phosphate without altering the supply of 5-phosphoribosyl 1 pyrophosphate. 5. The activity of ribose 5-phosphate pyrophosphokinase is low in uterine extracts and increases rapidly in response to oestradiol. Therefore the hormonal activation of the routes of purine nucleotide synthesis both de novo and from preformed precursors may be due, at least in part, to an increased availability of the common rate-limiting substrate 5-phosphoribosyl 1 pyrophosphate, mediated by activation of ribose 5-phosphate pyrophosphokinase. PMID- 4344698 TI - Protein fluorescence of lactate dehydrogenase. AB - 1. There is a non-linear decrease in the protein fluorescence (F) of lactate dehydrogenase with the increase in the fraction (alpha) of the coenzyme-binding sites occupied with NADH. 2. By a curve-fitting procedure it is shown that the fluorescence intensity can be represented by the equation F=[1-alpha(1-x)](n) where n is the number of identical and indistinguishable coenzyme-binding sites per protein molecule and x=F(s) (1/n) (F(s) is the protein fluorescence at alpha=1). This equation implies that the relative protein fluorescence of molecules bearing j ligands form the geometric series x(j). 3. Non-linear quenching of protein fluorescence for this enzyme is probably due to radiationless transfer of energy from the protein molecule to the bound NADH and should also be observed when other potential acceptors of protein fluorescence are bound at unique sites. 4. The intercept with F(s) of an initial tangent to a curve of protein fluorescence against alpha will be at a value of alpha equal to (K(d)+[E(0)]). (1-x(n))/n.(1-x) and not at a value equal to the sum of the dissociation constant (K(d)) and the concentration of identical ligand-binding sites ([E(0)]). 5. A use of non-linear protein fluorescence quenching to investigate the state of aggregation of a protein is discussed. PMID- 4344699 TI - The amino acid sequence of cytochrome c from Helix aspersa Muller (garden snail). AB - The amino acid sequence of a snail cytochrome c has been determined. The molecule consists of a single polypeptide chain of 104 residues, and is homologous with other mitochondrial cytochromes c. Unlike the cytochromes c from vertebrates, there is no acetyl blocking group at the N-terminus. A change in an otherwise invariant position has been observed in position 87. Comparison with amino acid sequences of cytochromes c from other sources indicates that the point of divergence of the molluscs and the vertebrates in evolutionary time was 720 million years ago. Experimental details are given in a supplementary paper that has been deposited as Supplementary Publication SUP 50009 at the National Lending Library for Science and Technology, Boston Spa, Yorks. LS23 7BQ, U.K., from whom copies can be obtained on the terms indicated in Biochem. J. (1972), 126, 5. PMID- 4344701 TI - DNA biosynthesis in nuclei. I. Characterization of DNA synthesis by isolated rat liver nuclei using endogenous DNA as primer. PMID- 4344702 TI - [Effect of colchicine and ethidium bromide on the content of radioactively marked uridine compounds in optic axons of teleosts]. PMID- 4344704 TI - [Radiological plain film findings in cyanotic neonates with congenital heart disease]. PMID- 4344703 TI - Changes in activity and hormonal sensitivity of brain adenyl cyclase following chronic ethanol administration. PMID- 4344705 TI - [Truncus arteriosus communis: haemodynamics and radiological appearances]. PMID- 4344706 TI - [Indications for demonstrating the superior vena cava and its major tributaries]. PMID- 4344707 TI - [Duplication of the inferior vena cava--angiographic demonstration of a rare anomaly]. PMID- 4344708 TI - [Chronic lung changes following nitrofurantoin medication]. PMID- 4344709 TI - [Scintigraphic tumor diagnostics using 75 Se sodium selenite in patients with malignant thoracic neoplasms]. PMID- 4344710 TI - [Phlebographic localization of supra-renal adenomas in primary aldosteronism]. PMID- 4344711 TI - [Spread of traumatic thrombosis of the transverse sinus with special reference to the angiographic findings]. PMID- 4344712 TI - [Spontaneous healing of carotid-cavernous fistulas]. PMID- 4344713 TI - [Gastro-jejunal invagination following gastric resection]. PMID- 4344714 TI - [Radiographic picture of esophageal and gastric caustic burns due to acids and alkalies]. PMID- 4344715 TI - [Two-channel color scintigraphy of the pancreas]. PMID- 4344716 TI - [Cinedensitometry of portal circulation. Methods and initial results]. PMID- 4344717 TI - [Video densitometry with flexible window size using light-limiting diaphragm]. PMID- 4344720 TI - [Comment on the work of N. Psathakis and R. Schneider on "Findings following gracilis tendon plastic surgery in varicosis of the lower extremities with special reference to phlebographic findings" in Fortschr. Roentgenstr. 116, 496 8, 1972]. PMID- 4344718 TI - [New results of lung densitometry in childhood using the Compton effect]. PMID- 4344719 TI - [Limitations of 70 mm fluorography]. PMID- 4344721 TI - [Final note on the work of N. Psathakis and R. Schneider in Fortschr. Roentgenstre. 116, 496-8, 1972]. PMID- 4344722 TI - [Radiological-anatomical aspects of breast carcinoma located next to a proliferating cyst]. PMID- 4344723 TI - [Giant fibroadenoma of the breast]. PMID- 4344725 TI - Preparation and characterization of an inorganic analog for the active site of the reduced 2Fe-S iron-sulfur proteins. PMID- 4344724 TI - [Chronic nonspecific granulomatous gastroduodenitis (Crohn)]. PMID- 4344726 TI - Adrenocortical steroidogenesis: studies on the mechanism of action of angiotensin and electrolytes. AB - The effects of adrenocorticotropin (ACTH), angiotensins I and II, increased potassium, and decreased sodium concentrations upon steroid synthesis were examined by incubation of beef adrenal tissue slices. Angiotensin II shared with ACTH the need for calcium and an inhibition of its effect in the presence of puromycin but differed in not stimulating cyclic adenosine monophosphate (AMP). Angiotensin I was effective in steroidogenesis. The stimulation of aldosterone synthesis by increased potassium concentration was accompanied by an increased level of cyclic AMP and was inhibited in the presence of puromycin. Decreased sodium concentration stimulated aldosterone synthesis but, alone of these stimuli, simultaneously decreased corticosterone levels. It therefore appears that ACTH and potassium stimulate steroidogenesis at an early step in the biosynthetic pathway through the activation of cyclic AMP, whereas the effect of angiotensins I and II involve another mechanism and decreased sodium concentration affects a later step in steroidogenesis. PMID- 4344727 TI - Adrenocortical steroidogenesis: the effects of prostaglandins. AB - Prostaglandins E(1) and E(2) significantly stimulated the synthesis of aldosterone, corticosterone, and to a lesser degree, cortisol in the outer slices of beef adrenal tissue. PGA, PGF(1a), and PGF(2a) were ineffective.PGE(1) was found to stimulate steroidogenesis in a manner similar to that of adrenocorticotropin (ACTH) in (a) needing calcium, (b) being inhibited by puromycin but not actinomycin D, (c) increasing the levels of cyclic AMP, and (d) not having an additive effect to exogenous cyclic AMP. PGE(1) did not produce an additive effect with either submaximal or maximal amounts of ACTH but did have an additive effect with angiotensin. These results are in keeping with the hypothesis that PGE(1) shares a receptor site on the plasma membrane with ACTH. PMID- 4344728 TI - The effect of steroids and ammonium chloride acidosis on phosphoenolpyruvate carboxykinase in rat kidney cortex. II. The kinetics of enzyme induction. AB - The kinetics of the induction of rat kidney phosphoenolpyruvate carboxykinase activity after triamcinolone and ammonium chloride administration have been investigated with a view to the further differentiation of the two processes. The half-life of kidney phosphoenolpyruvate carboxykinase activity, as measured from the decay curve after a single doses of triamcinolone, is approximately 1.4 hr. This compares with a half-life for the enzyme from acidotic kidney of approximately 3.4 hr. Analysis of the data indicates that the induction of phosphoenolpyruvate carboxykinase activity by triamcinolone may be attributed to an increase in de novo protein synthesis. Induction by acidosis is qualitatively distinct and is partly attributed to a reduction in the rate of decay of phosphoenolpyruvate carboxykinase activity. The activities of the gluconeogenic enzymes glucose-6-phosphatase, fructose-1,6-diphosphatase, and phosphoenolpyruvate carboxykinase in both liver and kidney have been measured in animals separately treated with triamcinolone and ammonium chloride. Triamcinolone significantly increases the activities of liver phosphoenolpyruvate carboxykinase, kidney glucose-6-phosphatase, and kidney phosphoenolpyruvate carboxykinase only; ammonium chloride stimulates a 200% increase in kidney phosphoenolpyruvate carboxykinase, but has no effect on the other enzymes. The induction processes whereby triamcinolone increases phosphoenolpyruvate carboxykinase activities in liver and kidney differ quantitatively. PMID- 4344729 TI - Localization of the action of cholera toxin on adenyl cyclase in mucosal epithelial cells of rabbit intestine. AB - Brush borders and plasma membranes have been purified from mucosal epithelial cells of rabbit ileum under control conditions and after treatment for 3 hr with cholera toxin in vivo. The activity of several enzymes in these preparations was measured. It was concluded that adenyl cyclase, like NaK-ATPase, seems not to be a normal constituent of brush borders. Both these enzymes are present in plasma membrane preparations derived largely from the basal and lateral margins of the epithelial cells, both may be phospholipid dependent enzymes and both are affected by cholera toxin. Adenyl cyclase activity is increased while NaK-ATPase is decreased. The activities of alkaline phosphatase, leucineaminopeptidase, 5' nucleotidase, glucose-6-phosphatase, and Mg-ATPase were not found to be affected by the toxin. Cholera toxin, which makes contact with the luminal side of the epithelial cells, in the natural disease and in the experimental model, would appear to exert its pathologic effect on adenyl cyclase at the opposite (basal and lateral) side of the cells. PMID- 4344730 TI - Effect of prostaglandin E 1 on certain renal actions of parathyroid hormone. AB - Parathyroid hormone increased basal adenyl cyclase activity and that increase was inhibited by prostaglandin E(1) (PGE(1)). Tissue cyclic 3',5'-adenosine monophosphate (cyclic AMP) concentrations were increased by parathyroid hormone and that increase was likewise inhibited by PGE(1). Both parathyroid hormone and dibutyryl cyclic AMP increased (32)P incorporation into renal cortical phospholipids. PGE(1) diminished the effect of parathyroid hormone but not dibutyryl cyclic AMP to influence that parameter. PGE(1) likewise modulated the effect of parathyroid hormone but not dibutyryl cyclic AMP to decrease fractional phosphate reabsorption by the renal tubule. It is suggested that PGE(1) inhibits the effect of parathyroid hormone by decreasing its effect on adenyl cyclase. Such interaction may be important in modulating the intracellular action of parathyroid hormone on kidney cortex. PMID- 4344732 TI - The effect of sulfonylurea drugs on rabbit myocardial contractility, canine purkinje fiber automaticity, and adenyl cyclase activity from rabbit and human hearts. AB - Long-term clinical studies have associated tolbutamide therapy with an increased incidence of cardiovascular deaths. The effects of this and other sulfonylurea drugs on contractility and rate of isolated rabbit atria, automaticity of isolated dog Purkinje fibers, and adenyl cyclase activity in particulate preparations of rabbit and human hearts were studied. At concentrations that are attained clinically, tolbutamide (10 mg/100 ml) increased contractility of driven rabbit atria to 124+/-5% of control, acetohexamide (3.9 mg/100 ml) to 140+/-5%, chlorpropamide (8.3 mg/100 ml) to 139+/-6%, and tolazamide (3.1 mg/100 ml) to 119+/-6%. These effects were accentuated in the presence of 2.5 x 10(-4) M theophylline and were not blocked by 1 x 10(-5) M propranolol. Adenyl cyclase was activated by each of these drugs at concentrations below those which increase contractility. The drugs also increased the rate and slope of phase 4 depolarization in spontaneously beating Purkinje fibers, but did not alter the spontaneous rate of isolated rabbit atria. Since inotropic and chronotropic stimulation can be deleterious in some clinical settings, these findings may be of significance in interpretation of cardiovascular mortality data. PMID- 4344731 TI - Lipids of alveolar macrophages, polymorphonuclear leukocytes, and their phagocytic vesicles. AB - Phagocytic vesicles were isolated from rabbit alveolar macrophages and guinea pig polymorphonuclear leukocytes that had ingested emulsified paraffin oil. Phospholipids and their fatty acids were determined in whole cells and in the phagocytic vesicle and pellet fractions separated from them. The cholesterol-to phospholipid ratios in the vesicle fractions were distinctly higher than those of the respective whole cells or pellet fractions. The vesicle fractions also had higher phospholipid-to-protein ratios than did the whole cells. The phospholipids of the phagocytic vesicle fraction from macrophages contained relatively more sphingomyelin, lyso-(bis)phosphatidic acid, and phosphatidylserine and less lecithin, phosphatidylethanolamine, and phosphatidylinositol than did the whole cells or pellet fractions. The phospholipids of phagocytic vesicles from polymorphonuclear leukocytes contained significantly more phosphatidylinositol than did the pellet fractions. Lyso(bis)phosphatidic acid, which constituted 15% of the phospholipid in rabbit alveolar macrophages and 25% of that in their phagocytic vesicles, contained almost 60% oleic acid and 20% linoleic acid. This lipid was not detected in rabbit peritoneal macrophages or in rat alveolar macrophages.The polyunsaturated fatty acids of leukocyte phospholipids were chiefly linoleic, whereas in macrophages arachidonic accounted for almost 20% of the total fatty acids. The macrophages produced malondialdehyde when ingesting polystyrene beads or emulsified paraffin oil, from which it was inferred that peroxidation of endogenous lipid can occur during phagocytosis. Polymorphonuclear leukocytes in which less than 3% of phospholipid fatty acids were arachidonic did not produce malondialdehyde during phagocytosis of these inert particles, but did when ingesting an emulsion containing linolenate, thus providing evidence for peroxidation of ingested lipid. Isolated phagocytic vesicles from alveolar macrophages contained lipid peroxides and generated malondialdehyde when incubated with ADP, FeCl(3), and NADH. PMID- 4344733 TI - Ultrafiltration of lipoproteins through a synthetic membrane. Implications for the filtration theory of atherogenesis. AB - To investigate the interaction of lipoproteins with semipermeable membranes, solutions of low density lipoproteins (LDL), very low density lipoproteins (VLDL), mixtures of the two, and diluted, normal, and hyperlipidemic serum were ultrafiltered through a synthetic membrane (500 A nominal pore diameter) using a stirred laboratory ultrafiltration cell. The pressure dependence of ultrafiltrate flux showed that a concentrated layer of lipoproteins was built up at the membrane surface (concentration polarization) and that VLDL was more subject to polarization than LDL. This phenomenon controlled the observed lipoprotein transport behavior. Whereas true membrane rejection (the fraction of the solute on the membrane surface which does not pass through the membrane) was greater than 0.95 for both LDL and VLDL, observed solute rejection varied from nearly 0 to 1.0, depending upon experimental conditions. If concentration polarization occurs in the arterial system, these results suggest that lipoprotein transport into arterial wall may be influenced not only by arterial blood pressure and the properties of the arterial wall, but also by local hemodynamic conditions and by the relative as well as absolute magnitudes of LDL and VLDL concentration. PMID- 4344734 TI - Hormonal control of the renal conversion of 25-hydroxycholecalciferol to 1,25 dihydroxycholecalciferol. AB - Isolated renal tubules from vitamin D-deficient chicks catalyse the in vitro conversion of 25-hydroxycholecalciferol to 1,25-dihydroxycholecalciferol. This conversion is stimulated by 5 x 10(-10) M bovine parathyroid hormone, or by 10( 6) M cyclic AMP. It is inhibited by 10(-9) M porcine calcitonin. It is concluded that these hormonal controls of the synthesis of the renal hormone 1,25 dihydroxycholecalciferol are of particular physiological significance in coordinating the activities of the various organs involved in extracellular calcium homeostasis. PMID- 4344735 TI - Hyperlipoproteinemia type IV and pre-beta-lipoprotein. Some new aspects of its physiology, pathogenesis and diagnosis. PMID- 4344737 TI - [Extramammary Paget's disease--studies on the malignant development]. PMID- 4344736 TI - [Peripheral neurologic manifestations of chronic alcoholism]. PMID- 4344738 TI - [Cortisone and anti-asthma therapeutic agents in children and adults. Current evaluation]. PMID- 4344739 TI - Residual cerebellar systems dysfunction and peripheral neuropathy after diphenylhydantoin therapy. PMID- 4344741 TI - [Histiogenesis, etiology, morphology and clinical aspects of bronchiolo-alveolar carcinoma]. PMID- 4344740 TI - Pathogenicity of some clones from field isolates of avian leukosis viruses. PMID- 4344742 TI - Resistance to denaturation by periodate of a dialyzable form of BALB-c histocompatibility antigen. PMID- 4344743 TI - Oxidative metabolism of brain tumors. PMID- 4344744 TI - [Immunochemical studies on bacterial cell membrane--with special reference to membrane-specific common antigen]. PMID- 4344745 TI - [Multiplication of Chlamydia and conversion of its cell wall]. PMID- 4344746 TI - Humoral responses of smooth muscle from rabbit subarachnoid artery compared to kidney, mesentery, lung, heart, and skin vascular smooth muscle. PMID- 4344747 TI - Absence of chronotropic effects of dibutyryl cyclic adenosine 3',5'-monophosphate on the dog S-A node. PMID- 4344748 TI - The relative value of pyelography, angiography and scintigraphy in the diagnosis of renal tumors. PMID- 4344749 TI - Optical and electron microscope studies on the excretory bladder of the supposed epitheliocystid cercaria of Ochetosoma aniarum. PMID- 4344750 TI - [Morphological study of pathogenic and potentially pathogenic amoebae of the types "Entamoeba" and "Hartmannella-Acanthamoeba" from reptiles]. PMID- 4344751 TI - [Ultrastructural study of developmental stages of Eimeria maxima (Sporozoa, Coccidia). II. Fine structure of microgametes]. PMID- 4344752 TI - [Cytochemical studies on Besnoitia jellisoni cysts. Distribution of acid phosphatase and polysaccharide at the ultrastructural level]. PMID- 4344754 TI - [Cultivation of a bovine leukosis agent in cattle leukocyte cultures. 1. Comparative studies on the behavior of leukocytes from leukemic and leukosis-free cattle in culture]. PMID- 4344753 TI - Ultrastructural observations on the epidermis of the polyopisthocotylinean monogeneans Rajonchocotyle emarginata and Plectanocotyle gurnardi. PMID- 4344755 TI - [Cultivation of a bovine leukosis agent in cattle leukocyte cultures. 2. Infectivity of leukocyte cultures from leukemic cattle for calves]. PMID- 4344756 TI - [Conservative treatment and prevention of uterine myoma]. PMID- 4344757 TI - Isolation of a latent murine hepatitis virus from cultured mouse liver cells. PMID- 4344758 TI - Watery diarrhea, hypokalemia and achlorhydria associated with pancreatic cholera. Case report. PMID- 4344759 TI - Pharmacodynamics of repository adrenocorticotropic hormone preparations in man. PMID- 4344760 TI - Serum alpha-fetoprotein and resection of primary hepatic cancer. PMID- 4344761 TI - [Pathology of the pulmonary form of canary pox]. PMID- 4344762 TI - Synthesis of oligoribonucleotides with ribonuclease T 1 . PMID- 4344763 TI - Stimulation by thyrotropin of amino acid incorporation into proteins in dog thyroid slices in vitro. PMID- 4344765 TI - Observations on the mode of uptake of thorium dioxide particles by osteoclasts in fracture callus. PMID- 4344766 TI - Regulation of hemoglobin synthesis in the blood islands of chick blastodiscs. Tentative identification of the stimulatory transfer RNA as a minor alanine specific species. PMID- 4344767 TI - Reduction of folate and dihydrofolate by dithionite. PMID- 4344764 TI - Relationship between pyrophosphate, amorphous calcium phosphate and other factors in the sequence of calcification in vivo. PMID- 4344768 TI - Effects of aldosterone on mitochondrial enzyme(s) and cytochromes of rat tissues. PMID- 4344770 TI - Long-lasting corticotropic action of (1-Gly)-ACTH-(1-18)-octadecapeptide amide poly-L-aspartic acid complex. PMID- 4344769 TI - The conjugated estrogens. II. A new method for isolating estriol monoglucosiduronide from normal human pregnancy urine. PMID- 4344771 TI - Inactive forms of UDPG: -1, 4-glucan -4-glucosyltransferase. PMID- 4344773 TI - Activation of a ribonuclease on dispersion of rat liver to a single cell suspension and incubation of the cells at 37 degrees. PMID- 4344774 TI - Effect of cyclic AMP and cytochalasin B on tissue cultured melanophores of Xenopus laevis. PMID- 4344772 TI - The carbohydrate content of control and virus-transformed cells. PMID- 4344775 TI - Opposite effects of dibutyryl adenosine 3':5' cyclic monophosphate and serum on growth of Chinese hamster cells. PMID- 4344776 TI - Genetics of somatic mammalian cells. XV. Evidence for linkage between human genes for lactic dehydrogenase B and serine hydroxymethylase. PMID- 4344778 TI - [Cushing's syndrome]. PMID- 4344777 TI - [Effect of inferior vena cava constriction on plasma renin concentration and on Na-K ratio in urine]. PMID- 4344779 TI - [Early pathological type of scirrhous cancer of the stomach and the clinic pathological characteristics]. PMID- 4344780 TI - Intestinal juice level of various antibiotics administered parenterally. PMID- 4344781 TI - [Use of cytochrome C in corneal diseases associated with disorders of tissue respiration]. PMID- 4344782 TI - [Electrological aspect of infraclinical neuropathies in the course of alcoholism]. PMID- 4344783 TI - [Hyperaldosteronism]. PMID- 4344784 TI - [Absorption and urinary elimination of spiramycin following its i.m. administration]. PMID- 4344785 TI - Immunosuppressive drugs in rheumatoid arthritis. PMID- 4344786 TI - Corticosteroid-induced suppression of the cerebro-hypothalamo-pituitary-adrenal axis. PMID- 4344787 TI - [Unusual complications in acute lymphoblastic leukemia]. PMID- 4344788 TI - [After care and additional treatment in cancer patients]. PMID- 4344789 TI - Exocytosis in the adrenal medulla demonstrated by freeze-etching. AB - Replicas of fractured chromaffin cells are indicative of a range of activities thought to characterize exocytosis, including attachment of secretory vesicles to the plasma membrane, fusion, extrusion of contents, and membrane retrieval. Exocytosis sites are abundant on stimulated cells but are infrequent when calcium is omitted from the system. PMID- 4344790 TI - Cross-immunity among allogeneic tumors of rats. PMID- 4344791 TI - The structure of the organ of Bellonci of the syncarid crustacean, Anaspides tasmaniae (Thomson). PMID- 4344792 TI - The ultrastructure of the adenohypophysis of Myxine glutinosa. PMID- 4344794 TI - Fine structural and cytochemical observations on cytoplasmic nucleoluslike bodies in nerve cells of rat medulla oblongata. PMID- 4344793 TI - Electron microscopy of filaments in the basal part of rat kidney tubule cells, and their in situ interaction with heavy meromyosin. PMID- 4344795 TI - [Defense substances of arthropods. 58. Fine structure of the pygidial glands of the water beetle, Dytiscus marginalis L]. PMID- 4344796 TI - [Serum antibodies to various pathogenic agents and lymphocytic transformation in Behcet disease]. PMID- 4344797 TI - [Comparative uptake of 5-iodo-2'-deoxyuridine and thymidine into the nuclei of herpes simplex virus infected HeLa cells]. PMID- 4344798 TI - Application of electron microscopy to the study of plasma lipoprotein structure. PMID- 4344799 TI - Enzymatic systems that synthesize and degrade glycerolipids possessing ether bonds. PMID- 4344800 TI - Lipids in the nervous system of different species as a function of age: brain, spinal cord, peripheral nerve, purified whole cell preparations, and subcellular particulates: regulatory mechanisms and membrane structure. PMID- 4344801 TI - [Theca cell tumors of the ovaries]. PMID- 4344803 TI - The effect of bile acids on intestinal microflora. PMID- 4344804 TI - Plasmids in intestinal bacteria. PMID- 4344802 TI - The Guillain-Barre syndrome as a complication of the postperfusion syndrome. PMID- 4344805 TI - Relationships between protozoa and bacteria of the alimentary tract. PMID- 4344806 TI - Anticipating adolescent growth vectors and velocities. PMID- 4344807 TI - The human epidermal cells infected with herpes simplex virus in vitro. PMID- 4344808 TI - A Langerhans cell in the spongiform pustule of pustular psoriasis. PMID- 4344809 TI - [Ultrastructure of dermo-epidermal junction in Lichen planus]. PMID- 4344810 TI - Marker nucleotides for non-ribosomal spacer segments of preribosomal ribonucleic acid. PMID- 4344811 TI - Isolation of a helical, lipid-binding fragment from the human plasma high density lipoprotein, apoLP GLN-I. PMID- 4344812 TI - Kidney membrane cyclic AMP receptor and cyclic AMP-dependent protein kinase activities: comparison of plasma membrane and cytoplasmic fractions. PMID- 4344813 TI - Plant sterol metabolism. Demonstration and identification of a biosynthetic intermediate between farnesyl PP and squalene in a higher plant. PMID- 4344814 TI - On the tautomeric states of guanine and cytosine. PMID- 4344815 TI - Cyclic AMP in cultured human lymphoid cells: relationship to mitosis. PMID- 4344816 TI - Inosine 3',5'-monophosphate and adenosine 3',5'-monophosphate-dependent protein kinase from human PMN leucocytes. PMID- 4344817 TI - Increased cyclic AMP levels in malignant hepatic nodules of ethionine treated rats. PMID- 4344818 TI - Some properties of a glycoprotein isolated from adrenal cortex mitochondria. PMID- 4344819 TI - Accumulation of replicative intermediates and catenated forms of the colicinogenic factor E 1 in E. coli during the replication at elevated temperatures. PMID- 4344821 TI - [Dwarf form of Entamoeba histolytica]. PMID- 4344820 TI - Neurological complications of addiction to heroin. PMID- 4344822 TI - [Comparative study of the protective capacity of virus and allogenic, transformed cells in the polyoma virus-mouse system]. PMID- 4344823 TI - Simplified primary screening procedure for detection of hyperlipidemias in healthy individuals. PMID- 4344824 TI - Possible mechanisms for the increase in alkaline phosphatase activity of lyophilized control material. PMID- 4344825 TI - [Intracellular localization of cholesterol esterase in neoplasms]. PMID- 4344826 TI - Inhibition of the assembly of cytochrome oxidase in Neurospora crassa by chloramphenicol. PMID- 4344827 TI - Regulation of inositol biosynthesis in vivo by pyrophosphate in Neurospora crassa. PMID- 4344828 TI - Thermodynamic and kinetic characterization of electron transfer components in situ in Rhodopseudomonas spheroides and Rhodospirillum rubrum. PMID- 4344829 TI - Different pool sizes of the precursor polypeptides of cytochrome oxidase from Neurospora crassa. PMID- 4344831 TI - Sleep fantasy in normal and schizophrenic persons. PMID- 4344832 TI - The adaptive function of sleep: the differential effects of sleep and dreaming on recall. PMID- 4344830 TI - Studies on the reconstitution of apotransketolase with thiamine pyrophosphate and analogs of the coenzyme. PMID- 4344833 TI - Toxoplasmosis in the state hospitals of California. PMID- 4344834 TI - Laboratory diagnosis in toxoplasmosis. PMID- 4344835 TI - Management of the physician's (dermatologist's) office. PMID- 4344836 TI - Part-time residency training: an approach to the graduate training of some women physicians. PMID- 4344837 TI - Evidence for environmental factors in the etiology of Hodgkin's disease. PMID- 4344838 TI - Quantitative histologic distribution of adenosine-3',5-monophosphate in the rat adrenal and effect of adrenocorticotropin. PMID- 4344839 TI - Carcinoma of the male breast. PMID- 4344840 TI - [Clinical manifestations of fetal infections in the newborn. Viral infections]. PMID- 4344842 TI - Comparison of two culture media for primary isolation of Paracoccidioides brasiliensis from sputum. PMID- 4344841 TI - [Clinical features and diagnostics of bronchial adenoma. Report on 23 cases]. PMID- 4344843 TI - [Nutritional requirements of 4 species of Trichophyton verrucosum]. PMID- 4344844 TI - Precancer and carcinoma in chronic ulcerative colitis. A histopathological and clinical investigation. PMID- 4344845 TI - [Plasma somatotropin and urinary phenolsteroids in pneumic hypertrophic osteoarthropathy and paraneoplastic gynecomastia]. PMID- 4344846 TI - [Electroencephalographic changes and antitubercular treatments]. PMID- 4344847 TI - [Kahler's disease with subcostal plasmacytoma, pleurisy and plasma cell pericarditis]. PMID- 4344848 TI - [Aspergillar septicemia and disseminated aspergillosis (apropos of 2 cases)]. PMID- 4344849 TI - [Oil pneumopathies in adults. Apropos of a pseudotumoral case]. PMID- 4344850 TI - A method for estimation of renin activity in plasma. PMID- 4344853 TI - [Principles of functional organization of the human brain]. PMID- 4344851 TI - [Comparative characteristics of subunits of lipid-containing respiratory viruses]. PMID- 4344852 TI - [Lipid metabolism in tolerance to experimental atherosclerosis induced by homologous beta-lipoproteins in newborn animals]. PMID- 4344855 TI - Relation between socio-economic status and skeletal maturation of Chinese children. PMID- 4344854 TI - [Differential diagnosis and surgery of carotid glomus tumours]. PMID- 4344856 TI - [Advantages of color lymphography in surgery of malignant gynecologic tumors]. PMID- 4344858 TI - Differential effect of para-chlorophenylalanine on the two slow wave sleep stages in the cat. PMID- 4344857 TI - [Electrocardiographic changes following lymphography]. PMID- 4344859 TI - Complement-fixation test for detection of viral antibodies in chicken serum. I. Standardization of the test for detection of antibodies to Newcastle disease virus and polyoma virus. PMID- 4344860 TI - An inhibition test for identifying the neuraminidase antigen on influenza viruses. PMID- 4344861 TI - Diagnosis, pathology, and etiology of tenosynovitis in broilers and broiler breeders. PMID- 4344862 TI - The effect of intranasal exposure of chickens to the Fahey-Crawley virus on the development of synovial lesions. PMID- 4344863 TI - Isolation and characterization of an enteric reovirus causing high mortality in turkey poults. PMID- 4344864 TI - Growth of duck hepatitis virus in chicken embryos and in cell cultures derived from infected embryos. PMID- 4344865 TI - Conditions for isolation and study of enzymic properties of human liver mitochondria. PMID- 4344866 TI - [DNA polymerases in rat liver: thiol groups and enzyme activity]. PMID- 4344867 TI - [Sphingomyelinase activity in the cortex, corpus callosum and brain of rats during their development]. PMID- 4344868 TI - [Demonstration of several antigens in the LDL fraction of human serum lipoproteins]. PMID- 4344869 TI - Detection of heaptitis-associated antigen and anti-HAA. Comparison of radioimmunoassay and counterimmunoelectrophoresis. PMID- 4344870 TI - Diphenylhydantoin and insulin-secreting tumors. PMID- 4344872 TI - [Kidney failure and internal secretion--with special reference to the renin angiotensin-aldosterone system]. PMID- 4344871 TI - Role of virus in collagen diseases. PMID- 4344873 TI - [Chronic kidney failure and the renin-angiotensin system]. PMID- 4344874 TI - [ 131 I-labelled tumor-specific antibodies: trial to concentrate radioisotopes specifically in the tumor. I. Binding of anti-mouse hepatoma antibody to the tumor]. PMID- 4344875 TI - A possible mechanism of RNA replication in Rous sarcoma virus. PMID- 4344876 TI - A florilegium of experiments on directional hearing. PMID- 4344877 TI - Steady state contribution of the Na, K-pump to the membrane potential in identified neurons of a terrestrial snail, Helix pomatia. PMID- 4344878 TI - Motoneurone models based on 'voltage clamp equations' for peripheral nerve. PMID- 4344879 TI - The impact of viral diagnostic studies on medical practice: a report of three years' experience with enterovirus isolation in a hospital laboratory. PMID- 4344880 TI - Spot test for vanillylmandelic acid and other guaiacols in urine of patients with neuroblastoma. PMID- 4344881 TI - Viral placentitis in congenital cytomegalovirus infection. PMID- 4344882 TI - Serum LDH assays. PMID- 4344883 TI - Antibody titers in lupus erythematosus. PMID- 4344884 TI - [Electroretinoencephalography: clinical value and indications for use in the dynamic exploration of the visual pathways in neurology]. PMID- 4344885 TI - A new chemical probe for single-stranded RNA. PMID- 4344886 TI - Oxidation of cytochrome c peroxidase with hydrogen peroxide: identification of the "endogenous donor". PMID- 4344888 TI - Cell cycle variation in cyclic adenosine 3',5'-monophosphate-dependent inhibition of protein kinase from Physarum polycephalum. PMID- 4344887 TI - Activation of hormone-sensitive lipase from adipose tissue by cyclic AMP dependent protein kinase. PMID- 4344889 TI - Protein kinase activities in rat epididymis. Effects of maturation and testosterone treatment. PMID- 4344890 TI - Streptomycin lethality and cyclic AMP. PMID- 4344891 TI - The primary structure of yeast initiator transfer ribonucleic acid. PMID- 4344892 TI - Ligand induced molecular weight transitions in Rhodopseudomonas palustris fructose 1,6-diphosphatase. PMID- 4344893 TI - Activation of yeast inorganic pyrophosphatase by magnesium. PMID- 4344895 TI - Function of calcium ions in pyruvate dehydrogenase phosphatase activity. PMID- 4344894 TI - Activation energies of different mitochondrial enzymes: breaks in Arrhenius plots of membrane-bound enzymes occur at different temperatures. PMID- 4344897 TI - Insulin-stimulated plasma membranes from rat adipocytes: their physiological and physicochemical properties. PMID- 4344896 TI - Studies on gluconeogenesis, protein synthesis and cyclic AMP levels in isolated parenchymal cells following insulin withdrawal from alloxan diabetic rats. PMID- 4344898 TI - [Paradoxical sleep and learning in 2 consanguinous strains of mice]. PMID- 4344899 TI - [Adenylate cyclase and phosphodiesterases in somatic hybrids of glial cells]. PMID- 4344900 TI - [Changes in phosphorylated fractions and adenylic nucleotides in the rat myocardium under the comparative effect of epinephrine and norepinephrine]. PMID- 4344901 TI - [Results of a trial premunition of mice against myxovirus infections by means of a methylated homologous ribonucleic acid]. PMID- 4344902 TI - [Toxicity of a synthetic polyanion with antiviral activity: polyvinyl sulfate]. PMID- 4344903 TI - [Molecular thuricins and cerecins]. PMID- 4344904 TI - [Cortisol and corticosterone secretion by adrenal glands transplanted to the neck in dogs]. PMID- 4344905 TI - [Demonstration of hydroxysteroid dehydrogenases in the testis of certain Cercopithecidae of Ivory Coast]. PMID- 4344906 TI - [In vitro effect of a thymus extract on the action of adrenocorticotropic hormone (ACTH)]. PMID- 4344907 TI - Comparative studies on angiotensins. II. Structure of rat angiotensin and its identification by DNS-method. PMID- 4344909 TI - On the presence of a non-trimethylated iso-1 cytochrome c in a wild-type strain of Saccharomyces cerevisiae. PMID- 4344908 TI - Alkylation of phosphates and stability of phosphate triesters in DNA. PMID- 4344910 TI - Candida krusei chtochrome c: a correction to the sequence. Glutamine-16, an invariant residue in mitochondrial cytochrome c? PMID- 4344911 TI - Binding of reduced cofactor to glutamate dehydrogenase. PMID- 4344912 TI - Metabolism of isolated kidney tubules. Additive effects of parathyroid hormone and free-fatty acids on renal gluconeogenesis. PMID- 4344913 TI - [Perspectives of a psychiatric care structure in Germany]. PMID- 4344914 TI - Relationships of HL-A antigens to human species-specific antigens. PMID- 4344915 TI - Malignant embryonal nephroma in an aged dog. PMID- 4344916 TI - Effect of oxygen on several enzymes involved in the aerobic and anaerobic utilization of glucose in Escherichia coli. AB - By using the continuous culture technique, the transition from aerobiosis to anaerobiosis and its effect on a number of enzymes has been investigated in Escherichia coli K-12. A decrease in the oxygen partial pressure below 28.0 mm of Hg resulted firstly in an increase of the respiratory enzymes (reduced nicotinamide adenine dinucleotide [NADH] oxidase, 2.53-fold; succinic dehydrogenase, 1.4-fold; cytochrome b(1), 3.91-fold; and cytochrome a(2), 2.45 fold) before the electron transport system gradually collapsed as cytochrome a(2), followed by cytochrome b(1), succinic dehydrogenase, and finally NADH oxidase decreased in activity. The change from respiration to fermentation was initiated well before the oxygen tension reached zero by the increase in levels of fructose diphosphate-aldolase, glucose 6-phosphate, and 6-phosphogluconate dehydrogenases and a decrease in 2-oxoglutarate dehydrogenase. Whem the dissolved oxygen tension reached zero, dry weight and CO(2) formation together with isocitrate dehydrogenase decreased, whereas acid production and phosphofructokinase synthesis started to increase. Enzymatic investigations revealed that the kinetics of the enzyme phosphofructokinase from strict aerobic cultures (6.9 ppm oxygen in solution) was adenosine triphosphate (ATP) insensitive, whereas the same enzyme from anaerobic cultures was ATP-sensitive. A mechanism is proposed for the change from aerobiosis to anaerobiosis together with the occurring change in glucose regulation. PMID- 4344917 TI - Ubiquinone function in Neurospora crassa. AB - Mitochondria of cytoplasmic respiratory mutants [mi-1] (poky) and [mi-4] contain about a fourfold molar excess of ubiquinone as compared to the wild-type strain of Neurospora crassa. In the wild type and [mi-1] cultures the concentration of ubiquinone remains constant during the exponential and stationary phase of growth. In [mi-4] cultures it markedly decreases in the stationary phase. The reduction of ubiquinone by substrates is approximately the same in the three strains tested and amounts 60 to 70% of total ubiquinone present in mitochondria, independent of its absolute amount. The reduction of ubiquinone on addition of substrates is accompanied by the similar reduction of cytochrome c. These indicate that mitochondrial ubiquinone and cytochrome c are involved in processes of oxidation in Neurospora and that ubiquinone belongs mainly if not entirely to the cytochrome system of electron transport in these strains. PMID- 4344918 TI - Lipids of Thermoplasma acidophilum. AB - Cells of Thermoplasma acidophilum contain about 3% total lipid on a dry weight basis. Total lipid was found to contain 17.5% neutral lipid, 25.1% glycolipid, and 56.6% phospholipid by chromatography on silicic acid. The lipids contain almost no fatty acid ester groups but appear to have long-chain alkyl groups in ether linkages to glycerol. The phospholipid fraction includes a major component which represents about 80% of the lipid phosphorus and 46% of the total lipids. We believe this component to be a long-chain isopranol glycerol diether analogue of glycerolphosphoryl monoglycosyl diglyceride. The glycolipids appear to contain isopranol diether analogues. Several components of the complex, neutral lipid fraction have been identified as hydrocarbons, vitamin K(2)-7, and isopranol glycerol diether analogues. Sterols are present in the neutral lipids but do not appear to be synthesized by the organism. PMID- 4344919 TI - Localization of phosphoglucose isomerase in Escherichia coli and its relation to the induction of the hexose phosphate transport system. AB - The localization of phosphoglucose isomerase (PGI) was studied in relation to the induction of hexose phosphate uptake in Escherichia coli. The uptake system is induced only by extracellular glucose-6-phosphate (G6P); there is no induction by intracellular G6P. Fructose-6-phosphate (F6P) is an indirect inducer, and isomerization of F6P to G6P must occur before induction. PGI has been considered to be an internal enzyme; therefore, uptake of F6P by noninduced cells and leakage of the G6P formed would be required for induction. In this study, it was concluded that part of the PGI activity is located in the cell surface because: (i) uninduced, intact cells are able to convert F6P to G6P, whereas the activity of G6P dehydrogenase is not detectable; (ii) when cells are subjected to osmotic shock, about 10% of the PGI activity is found in the shock fluid; and (iii) sorbitol-6-phosphate (S6P) inhibits both PGI activity of whole cells and the induction of hexose phosphate transport system by F6P. S6P was not taken by intact cells. The data indicate that the isomerization of F6P to G6P can take place on the cell surface, and this explains the indirect induction of hexose phosphate transport by F6P. PMID- 4344920 TI - Excision repair characteristics of recB - res - and uvrC - strains of Escherichia coli. AB - An Escherichia coli strain carrying the recB21 and res-1 mutations showed an abnormally low level of colony-forming ability although it grew essentially normally in liquid medium. The recB21 res-1 strain showed little, if any, of the ultraviolet (UV)-induced deoxyribonucleic acid (DNA) breakdown characteristic of the res-1 mutant. Nevertheless, the double mutant was far more sensitive to UV than either the res-1 or the recB21 strain. When compared with a wild-type strain, the rate of release of dimers from UV-irradiated DNA was very slow in the recB21 res-1, but normal in the res-1 recB(+) or recB21 res(+) mutants. However, the ratio of dimer-to-thymine released into the acid-soluble fraction was three times higher than the wild type in recB21 res(+) and recB21 res-1 and only one tenth as high as the wild type in res-1 rec(+). Alkaline sucrose gradient centrifugation revealed occurrence of single-strand incision of UV-irradiated DNA and the restitution of nicked DNA at a similar rate in the recB21 res-1 and recB21 res(+) strains. Mutants uvrC(-) showed increased amounts of nicks in their DNA with increasing incubation time after UV irradiation, although no detectable amounts of dimers were excised from UV-irradiated DNA. From these results, it is concluded that the increased sensitivity of the res-1 strain to UV light is due to a reduced ability to excise dimers from UV-irradiated DNA and that the high rate of UV-induced breakdown of DNA is not the primary cause. A possible role of uvrC gene in the excision repair is discussed. PMID- 4344921 TI - Isolation of polyisoprenyl alcohols from Streptococcus faecalis. AB - C(55)-isoprenyl alcohol and its derivatives have been isolated from Streptococcus faecalis and characterized. The relative amounts present as free alcohol, neutral lipid esters, and phosphate ester derivatives were determined. The chain lengths, mass spectra, and cis to trans ratio of double bonds are reported. PMID- 4344923 TI - Serum concentrations of 25-hydroxyvitamin D in sex-linked hypophosphatemic vitamin D-resistant rickets. PMID- 4344922 TI - Carbon monoxide production from heme compounds by bacteria. AB - Carbon monoxide formation from heme compounds by bacteria was investigated to study microbial hemoprotein catabolism with reference to heme degradation by mammalian tissues. Hemolytic and nonhemolytic bacteria were incubated aerobically and anaerobically with the following substrates: erythrocytes, hemoglobin, myoglobin, cytochrome c, hematin, iron hematoporphyrin, copper hematoporphyrin, protoporphyrin, and bilirubin. After 18 hr at 37 C the evolved CO was measured by gas chromatography. None of the bacteria formed CO anaerobically. Under aerobic conditions both alpha-hemolytic Streptococcus mitis and hemolytic Bacillus cereus formed CO from all of the heme compounds tested, whereas nonhemolytic Streptococcus mitis did not evolve CO from any of the substrates. The hemolytic bacteria did not produce CO when the iron of heme was either replaced by copper or removed, as in copper hematoporphyrin and in protoporphyrin, respectively. PMID- 4344924 TI - Increased activity of two enzymes of pyrimidine biosynthesis de novo in erythrocytes from patients with the Lesch-Nyhan syndrome. PMID- 4344925 TI - Thrombocytopenia in murine cytomegalovirus infection. PMID- 4344926 TI - New specific angiotensin antagonists. (8-Valine)-, (8-isoleucine)-, and chlorambucil-des-1-aspartic,8-valine-angiotensins I. PMID- 4344928 TI - Structure and antischistosomal activity in the nitrofuran series. Requirement for a 5-nitro group in 3-(5-nitro-2-furyl)acrylic acid derivatives. PMID- 4344927 TI - Structure and antischistosomal activity in the nitrofuran series. Requirement for a 5-nitro-2-furyl-vinyl moiety based on comparison of 3-(5-nitro-2-furyl) substituted propionic, acrylic, and propiolic acid derivatives. PMID- 4344929 TI - Luteinizing hormone releasing hormone. Solid-phase synthesis of a 5-phenylalanine analog possessing high biological activity. PMID- 4344930 TI - [16 cases of malignant cutaneous melanoma observed in Negroes, at the Abedjan Hospital Center]. PMID- 4344931 TI - [Nutrition survey in childen from 1 to 4 years old in the Bouafle area (Ivory Coast)]. PMID- 4344932 TI - Laboratory aids in the diagnosis of metabolic bone disease. PMID- 4344933 TI - The pathophysiology and management of rickets. PMID- 4344934 TI - Hypophosphatemic vitamin D refractory rickets and osteomalacia. PMID- 4344935 TI - Paget's disease of bone: problems and management. PMID- 4344937 TI - Recurring digital fibrous tumours of childhood. PMID- 4344938 TI - Effect of increased aortic blood pressure on myocardial performance and metabolism during non-adrenergic inotropic stimulation of the heart. PMID- 4344936 TI - Membrane-lipid exchange: exchange of cholesterol between porcine serum lipoproteins and erythrocytes. PMID- 4344939 TI - Activity of -amylase and -1,4-glucosidase in subfractions of human liver homogenates. PMID- 4344940 TI - [Determination of the antigen of infectious canine hepatitis virus by the method of immunofluorescence]. PMID- 4344941 TI - Effects of nucleoside analogs on transcription of simian virus 40. PMID- 4344942 TI - Abortive infection of Japanese quail cells with avian sarcoma viruses. PMID- 4344943 TI - Electrophoretic analysis of the RNA of avian tumor viruses. PMID- 4344944 TI - Comparison of immature (rapid harvest) and mature Rous sarcoma virus particles. PMID- 4344945 TI - The phospholipid composition of Uukuniemi virus, a non-cubical tick-borne arbovirus. PMID- 4344946 TI - Differential effect of temperature on the replication of herpes simplex virus type 1 and type 2. PMID- 4344947 TI - Biological hydroxylations and ascorbic acid with special regard to collagen metabolism. PMID- 4344948 TI - Segmental measurements of systolic blood pressure in the extremities including the thumb and the great toe. PMID- 4344949 TI - Angiotensin II plasma levels in hypertensive patients. PMID- 4344950 TI - Disturbances in serum lipids and in their fatty acid composition following acute myocardial infarction. PMID- 4344951 TI - Concentrations and fatty acid composition of serum lipid fractions following ACTH in rabbits. PMID- 4344952 TI - Interrelationship of renin-substrate (angiotensinogen) production and pathological function of the adrenal cortex in the rat. PMID- 4344953 TI - [Isolation of herpes simplex virus from the aqueous humour of an eye affected by relapsing iridocyclitis]. PMID- 4344954 TI - [Immunological study of avian myeloblastosis virus RNA]. PMID- 4344955 TI - Ultrastructure of the lacrimal sac. PMID- 4344956 TI - Electron microscopical observations on mediastinal neurolemmoma, neurofibroma, and ganglioneuroma. PMID- 4344958 TI - Simplified radioimmunoassay for diagnostic serology. AB - A simplified, indirect radioimmunoassay is described for Escherichia coli, vaccinia virus, and herpesvirus. The antigens were affixed to glass cover slips; thus both the primary and secondary reactions take place on the cover slips, and the unbound antiserum is easily separated from the bound antiserum by rinsing. Rabbit or human immune sera were reacted with the antigens, and the primary immune complex was quantitated by a secondary reaction with (125)I-indicator globulin (anti-rabbit or anti-human). A direct relationship between the antiserum concentration and the (125)I absorption was established. Variations in titers were detectable, and the titers were comparable to complement fixation titers. Homologous and heterologous reactions were distinguishable. The method affords an objective, quantitative, and qualitative evaluation of antibody, and results are reproducible. PMID- 4344957 TI - Interferon production by human cells in vitro. AB - The relative capacity of several types of human cells and tissue to produce interferon was studied. Types of cells and tissue included were fibroblasts from embryos, foreskins, and biopsied skins; amnion cells; peripheral leukocytes; established lymphoid cell lines; established heteroploid cell lines; and chorioamniotic membrane. When Newcastle disease virus was used as the inducer, fibroblasts and amnion cells produced more interferon per 10(6) cells than leukocytes, lymphoid cells, and heteroploid cells. Only minor variations in interferon-producing capacity were observed among fibroblasts from 36 persons. Culture passage level, cell concentration, and inducer were factors that significantly affected interferon production. PMID- 4344959 TI - Chemically defined medium for growth and sporulation of Clostridium perfringens. AB - A chemically defined medium was developed that could support sporulation and growth of Clostridium perfringens strains ATCC 12916 and H9. This medium consisted of a modification of the basal medium of Boyd et al. plus 0.1% sodium thioglycolate and 0.5% monosodium glutamate. Five other strains grew, but did not sporulate, in this medium. With the addition of more vatamins into the medium, two more strains grew but did not sporulate. The effects of glucose, monosodium glutamate, ammonium glutamate, and sodium thioglycolate on growth and sporulation of C. perfringens ATCC 12916 in the defined medium was investigated. PMID- 4344960 TI - Quantitation of Clostridium perfringens type A enterotoxin by electroimmunodiffusion. AB - Conditions for quantitation of Clostridium perfringens type A enterotoxin by electroimmunodiffusion are described. As little as 0.01 mug of enterotoxin could be detected. Electroimmunodiffusion was more sensitive than either single gel diffusion or quantitation based on erythemal activity of the toxin in guinea pig skin. PMID- 4344961 TI - Measurement of respiratory volume for virus retention studies in mice. AB - A pressure plethysmograph for measuring respiratory volume in mice during exposure to virus aerosols is described. The respiratory frequency and tidal volume were measured, and from these data the minute ventilation was calculated. The mean respiratory frequency of adult, male mice was 255 per min; the mean tidal volume of 0.18 ml was inversely related to respiratory frequency. The standardized mean minute ventilation rate was 1.46 ml per g of body weight. The respiratory frequency and tidal volume of CD-1 and HA/ICR strains of mice of the same age were similar. The respiratory retention rate for a 2.7-mum aerosol of vesicular stomatitis virus was 41%, and 58% of the virus retained was found in the trachea and lung. PMID- 4344962 TI - Sporulation of Clostridium perfringens type A in vacuum-sealed meats. AB - Type A strains of Clostridium perfringens inoculated into vacuum-sealed packages of hamburger, roast beef, ground beef plus cream sauce, and turkey roll produced high levels of spores. PMID- 4344963 TI - Enhancement of murine leukemia virus replication in rat tumor cells containing rat C-type virus. AB - The yield of Maloney leukemia virus (MLV) from MLV-infected rat cells was shown to be enhanced in rat cells containing rat C-type virus. The MLV produced in these cells was shown to be identical to murine-derived MLV and devoid of properties related to rat C-type virus. PMID- 4344964 TI - [Chronic neurasthenic sleep disturbance. Examinations of night sleep using polygraphic EEG-recordings and subjective assessment of sleep]. PMID- 4344965 TI - Conditions for growth of an ovine Chlamydia (bedsonia) in cell culture. PMID- 4344966 TI - Review of viral disease of cats. PMID- 4344967 TI - [Cell kinetics in experimental silicosis]. PMID- 4344968 TI - Phase changes in the lipid moieties of sarcoplasmic reticulum membranes induced by temperature and protein conformational changes. PMID- 4344969 TI - Specific interaction of central nervous system myelin basic protein with lipids. Effects of basic protein on glucose leakage from liposomes. PMID- 4344970 TI - Steroid-phosphatidylcholine interactions in oriented multibilayers--a spin label study. PMID- 4344971 TI - Effect of cholesterol and water on the rigidity and order of phosphatidylcholine bilayers. PMID- 4344972 TI - The role of phosphatidylserine in the hormonal control of adenylate cyclase of rat liver plasma membranes. PMID- 4344973 TI - Acceleration of renal hypertension accompanied by increase in plasma volume as a result of prior thoracic sympathectomy. PMID- 4344974 TI - Neoplasia in renal transplant recipients. PMID- 4344975 TI - Assay of plasma renin activity using commercially available reagents. PMID- 4344976 TI - [Herpes simplex virus type 2: its distribution and relationship to cervical carcinoma]. PMID- 4344977 TI - In vitro release of prostaglandins from the renal medulla. PMID- 4344978 TI - Potentiation of the effects of exogenously applied ATP and purinergic nerve stimulation on the guinea-pig taenia coli by dipyridamole and hexobendine. PMID- 4344979 TI - Cyclic-AMP in the aqueous humor: the effects of adrenergic agents. PMID- 4344981 TI - [Spinal cord tumors. Considerations apropos of 52 cases]. PMID- 4344980 TI - Electron spin resonance studies on living cells. IV. Pathological changes in amphibian eggs and embryos. PMID- 4344982 TI - A study of the inhibition of the renin-angiotensin system in renal potassium wasting syndromes, including Bartter's syndrome. PMID- 4344983 TI - Mechanisms of active transport in isolated bacterial membrane vesicles. 8. The transport of amino acids by membranes prepared from Escherichia coli. PMID- 4344984 TI - Expansion of the kinetic model of differentiation in Dictyostelium discoideum. PMID- 4344985 TI - A site of action of thyrotropin. Stimulation of the conversion of glycerophosphate to phosphatidic acid in bovine thyroid slices. PMID- 4344987 TI - Pyridine nucleotide synthesis. Purification of nicotinamide mononucleotide pyrophosphorylase from rat erythrocytes. PMID- 4344986 TI - The mechanism of enzyme-catalyzed reduced nicotinamide adenine dinucleotide dependent reductions. Substituent and isotope effects in the yeast alcohol dehydrogenase reaction. PMID- 4344988 TI - Pyridinium precursors of pyridine nucleotides in perfused rat kidney and in the testis. PMID- 4344989 TI - Electron paramagnetic resonance evidence for a distinction between the two iron binding sites in transferrin and in conalbumin. PMID- 4344990 TI - The conformation of horse heart apocytochrome c. PMID- 4344991 TI - Five penicillin-binding components occur in Bacillus subtilis membranes. PMID- 4344992 TI - The 6-O-methylglucose-containing lipopolysaccharides of Mycobacterium phlei. Locations of the acyl groups. PMID- 4344993 TI - Phosphorylation of an endogenous membrane protein by an endogenous, membrane associated cyclic adenosine 3',5'-monophosphate-dependent protein kinase in human erythrocyte ghosts. PMID- 4344996 TI - [Effect of angiotensin I on the synthesis of aldosterone]. PMID- 4344995 TI - [Ovarian cancer in adults, at the Gustave-Roussy Institute 1960-1967. Clinical and prognostic study]. PMID- 4344994 TI - Thrombin-induced increase in intracellular cyclic 3',5'-adenosine monophosphate in human platelets. AB - The present data disagree with earlier suggestions that thrombin's effect on platelets is to cause a decrease in intracellular cyclic 3',5'-adenosine monophosphate. Washed human platelets or platelet-rich plasma were incubated at 37 degrees C with human thrombin. After centrifugation, the supernates were assayed for nucleotides and calcium released. The platelet pellets, and in some experiments the supernates as well, were assayed by radioimmunoassay for intracellular cyclic AMP. In the washed platelet system, increasing doses of thrombin to 0.5 U/cc induced increasing release of nucleotides and calcium. This was accompanied by an average twofold increase in intracellular cyclic AMP levels. Prostaglandin E(1), which inhibited 30-50% of release, induced a four- to fivefold increase in cyclic AMP levels that was additive to the cyclic AMP stimulatory effect of thrombin. Theophylline, which inhibited only 20-40% of nucleotide release, was synergistic with thrombin in the intracellular accumulation of cyclic AMP. The time-course of cyclic AMP accumulation in response to thrombin was slower than thrombin-induced nucleotide release. Similar findings were made in the platelet-rich plasma system where thrombin stimulation of nucleotide release also resulted in a marked accumulation of intracellular cyclic AMP. Thrombin did not appear to stimulate the release of intracellular cyclic AMP. The mechanism underlying these observations was not apparent. The thrombin had no measurable inhibitory effect on platelet phosphodiesterase activity in either intact washed cells or the platelet homogenate supernates. Furthermore, thrombin inhibited, rather than stimulated, platelet adenyl cyclase activity in both intact washed cells and washed platelet particulate fractions. Of note, however, was the finding that thrombin did not completely inhibit the adenyl cyclase activity of prostaglandin-stimulated cells. Further work is needed to clarify the significance of this observation.Nonetheless, the accumulation of intracellular cyclic AMP in response to thrombin observed in the present study suggests that the antagonistic actions of various agents on the platelet release reaction, thought to underlie platelet function, may depend upon a mechanism more intricate than a straightforward mediation through directly opposite effects on platelet cyclic AMP. PMID- 4344997 TI - Blockade of acetylcholine receptors by cobra toxin: electrophysiological studies. PMID- 4344998 TI - The incomplete conversion of hepatic cytochrome P-450 to P-420 by mercurials. PMID- 4344999 TI - The conversion of hepatic cytochrome P-450 to P-420 in normal and phenobarbital- and 3-methylcholanthrene-treated animals. PMID- 4345000 TI - Characteristic two-dimensional patterns of enzymatic digests of oncorna and other viral RNAs. PMID- 4345001 TI - Surface alterations of cells carrying RNA tumour virus genetic information. PMID- 4345002 TI - Dissociation and reassociation of infectious poliovirus particles. PMID- 4345003 TI - VSV pseudotype particles with the coat of avian myeloblastosis virus. PMID- 4345004 TI - VSV pseudotype produced in cell line derived from human mammary carcinoma. PMID- 4345005 TI - Interferon treatment inhibits Mengo RNA and haemoglobin mRNA translation in cell free extracts of L cells. PMID- 4345006 TI - Role of calcium and adenosine cyclic 3'-5' phosphate in action of adrenocorticotropin. PMID- 4345008 TI - Polygraphic sleep studies in cerebrovascular accidents. PMID- 4345007 TI - [Metastatic trophoblastic tumor; a patient studied by means of the immunochemical LH test (luteonosticon test)]. PMID- 4345010 TI - Facilities for surgery and survival prospects in lung carcinoma. A study from South-west Finland between 1952 and 1970. PMID- 4345011 TI - Mixed tumors of salivary glands: a 44 year study. PMID- 4345009 TI - Inhibition by chloramphenicol of amino azo dye carcinogenesis in rat liver: biochemical studies of plasma membranes. PMID- 4345012 TI - [Monkey disease, resembling infectious mononucleosis, induced by cytomegalovirus]. PMID- 4345013 TI - [Metastasis of ascitic neoplasms (pathogenesis of metastasis in experimental systems)]. PMID- 4345014 TI - [General principles of diagnosis of malignant neoplasms of the soft tissues]. PMID- 4345015 TI - [Plasma 11-hydroxycorticosteroid determination in regularly hemodialized patients]. PMID- 4345016 TI - Leucocytokinetic studies during viral hepatitis. PMID- 4345017 TI - Hormone-producing pancreatic islet-cell tumors and hyperplasia. PMID- 4345018 TI - The influence of various dihydroergotamine analogues on cyclic adenosine-3',5' monophosphate phosphodiesterase in the grey matter of cat brain in vitro. PMID- 4345019 TI - The influence of carbon dioxide on the reaction of isolated veins to vaso-active substances. PMID- 4345020 TI - Effects of arsenicals on interferon formation and action. PMID- 4345021 TI - The mannophosphoinositides of the unclassified Mycobacterium P 6 . PMID- 4345022 TI - [Villonodular synovitis of the knee in children]. PMID- 4345024 TI - [Poliomyelitis viruses: survey in Grenoble on 64 recent isolations in hospitals (with an attempted interpretation of some peculiar cases)]. PMID- 4345023 TI - [Dyschondroplasia and ovarian tumor]. PMID- 4345025 TI - Ultrastructural changes accompanying the recovery of "giant" cells of the Emerson strain of Chlorella. I. Autospore production. PMID- 4345026 TI - Stability and dissociation of the DNA complexes with distamycin A and Netropsin in the presence of organic solvents, urea and high salt concentration. PMID- 4345027 TI - Synthesis and properties of oligodeoxy-4-thiothymidylic acid. PMID- 4345028 TI - Selective chemical methylation of yeast alanine transfer RNA. PMID- 4345029 TI - Grouping of T 4 -specific messenger RNA by methylated albumin-coated kieselguhr column chromatography. PMID- 4345030 TI - Arrested development of myelin in chick optic tectum following deaferrentation. PMID- 4345031 TI - Neuronal degeneration in rat brain induced by 6-hydroxydopamine; a histological and biochemical study. PMID- 4345033 TI - Effect of stimulation on the number of synaptic vesicles in nerve fibres and terminals of the cerebral cortex in the cat. PMID- 4345032 TI - Elevation of REM sleep following inhibition of protein synthesis. PMID- 4345034 TI - Cerebello-rubrospinal effects on hindlimb motoneurons in the monkey. PMID- 4345035 TI - Serotonin and the regulation of the pituitary-adrenal system after deafferentation of the hypothalamus. PMID- 4345036 TI - Discharge properties of neurons of the parietal association cortex during states of sleep and wakefulness in the monkey. PMID- 4345037 TI - Metabolic effects of cyclic 9- -D-arabinofuranosyladenine 3',5'-monophosphate in L1210 cells. PMID- 4345038 TI - Antitumor effects of polynucleotides and theophylline. PMID- 4345039 TI - Variation of hepatic malic enzyme capacity with hepatoma susceptibility in mice of different genotypes. PMID- 4345040 TI - Antigenic comparison of bovine type C virus with murine and feline leukemia viruses. PMID- 4345041 TI - Imbalance in ornithine metabolism in hepatomas of different growth rates as expressed in formation of putrescine, spermidine, and spermine. PMID- 4345042 TI - Imbalance in ornithine metabolism in hepatomas of different growth rates as expressed in behavior of L-ornithine carbamyl transferase activity. PMID- 4345043 TI - Studies on the inhibition by ethionine of aminoazo dye carcinogenesis in rat liver. PMID- 4345044 TI - Increase of extravascular albumin pool and the intracellular accumulation of vesicles in transplanted Morris hepatoma 9121. PMID- 4345045 TI - Respiratory activity of mitochondria isolated from a transplantable islet-cell tumor and from the liver of tumor-bearing hamsters. PMID- 4345046 TI - Specific estrogen-binding capacity of the cytoplasmic receptor in normal and neoplastic breast tissues of humans. PMID- 4345047 TI - The nature of bacterial toxins. PMID- 4345048 TI - [Histochemical changes in the central nervous system in burns]. PMID- 4345049 TI - [Electromyographic characteristics of lysthenon action on neuromuscular transmission in myasthenia patients]. PMID- 4345050 TI - [Hepatic enzyme induction through drugs]. PMID- 4345051 TI - [Evaluation of the hazards of some industrial factors based on acid-base equilibrium indices]. PMID- 4345052 TI - [Virus-induced breast neoplasms in man?].